SNRPFP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.71737659
2ATP synthesis coupled proton transport (GO:0015986)5.40674452
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.40674452
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.34620330
5protein neddylation (GO:0045116)4.90922384
6ribosomal small subunit biogenesis (GO:0042274)4.88173909
7maturation of SSU-rRNA (GO:0030490)4.82042985
8ribosomal small subunit assembly (GO:0000028)4.76724674
9viral transcription (GO:0019083)4.71836768
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.71804933
11translational termination (GO:0006415)4.62848014
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.29194631
13ribosomal large subunit biogenesis (GO:0042273)4.27111859
14cotranslational protein targeting to membrane (GO:0006613)4.22091093
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.21745705
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.21745705
17NADH dehydrogenase complex assembly (GO:0010257)4.21745705
18protein targeting to ER (GO:0045047)4.17870353
19protein complex biogenesis (GO:0070271)4.14164648
20mitochondrial respiratory chain complex assembly (GO:0033108)4.13665599
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.09565574
22chromatin remodeling at centromere (GO:0031055)4.08089011
23translational elongation (GO:0006414)4.05716567
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.00544375
25DNA deamination (GO:0045006)4.00317685
26protein localization to endoplasmic reticulum (GO:0070972)3.92097321
27pseudouridine synthesis (GO:0001522)3.87720945
28GTP biosynthetic process (GO:0006183)3.85889570
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.83303331
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.83028696
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.83028696
32DNA replication checkpoint (GO:0000076)3.74661371
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.74225499
34translation (GO:0006412)3.72269449
35water-soluble vitamin biosynthetic process (GO:0042364)3.70742042
36ribonucleoprotein complex biogenesis (GO:0022613)3.68572815
37cellular component biogenesis (GO:0044085)3.68254012
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.67391164
39termination of RNA polymerase III transcription (GO:0006386)3.67391164
40respiratory electron transport chain (GO:0022904)3.63143217
41DNA double-strand break processing (GO:0000729)3.62829359
42respiratory chain complex IV assembly (GO:0008535)3.62728477
43electron transport chain (GO:0022900)3.62562997
44protein targeting to mitochondrion (GO:0006626)3.61803986
45rRNA modification (GO:0000154)3.59604381
46CENP-A containing nucleosome assembly (GO:0034080)3.56395638
47translational initiation (GO:0006413)3.52359037
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51302033
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.51225418
50rRNA processing (GO:0006364)3.50129777
51cellular protein complex disassembly (GO:0043624)3.49891192
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.46924441
53purine nucleoside triphosphate biosynthetic process (GO:0009145)3.45678565
54rRNA metabolic process (GO:0016072)3.42915909
55establishment of protein localization to mitochondrion (GO:0072655)3.39800605
56maturation of 5.8S rRNA (GO:0000460)3.39342364
57viral life cycle (GO:0019058)3.39028435
58UTP biosynthetic process (GO:0006228)3.35375612
59ATP biosynthetic process (GO:0006754)3.34619663
60protein localization to mitochondrion (GO:0070585)3.32652272
61CTP metabolic process (GO:0046036)3.32044746
62CTP biosynthetic process (GO:0006241)3.32044746
63kinetochore assembly (GO:0051382)3.32005703
64tRNA processing (GO:0008033)3.27094877
65ubiquinone biosynthetic process (GO:0006744)3.23440817
66ribonucleoside triphosphate biosynthetic process (GO:0009201)3.23027071
67pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.20050955
68cytochrome complex assembly (GO:0017004)3.19223031
69kinetochore organization (GO:0051383)3.14424404
70pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.12984683
71UTP metabolic process (GO:0046051)3.12151325
72ribosome biogenesis (GO:0042254)3.11162733
73guanosine-containing compound biosynthetic process (GO:1901070)3.09507930
74purine nucleobase biosynthetic process (GO:0009113)3.09383489
75cullin deneddylation (GO:0010388)3.07077455
76protein complex disassembly (GO:0043241)3.06019489
77histone exchange (GO:0043486)3.04901439
78protein deneddylation (GO:0000338)3.04226113
79nucleobase biosynthetic process (GO:0046112)3.03013800
80pyrimidine nucleotide catabolic process (GO:0006244)3.01252525
81peptidyl-histidine modification (GO:0018202)3.01138001
82DNA damage response, detection of DNA damage (GO:0042769)3.00906405
83intracellular protein transmembrane import (GO:0044743)3.00073220
84behavioral response to nicotine (GO:0035095)2.99804729
85pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.98553822
86inner mitochondrial membrane organization (GO:0007007)2.98524263
87ncRNA processing (GO:0034470)2.98044792
88macromolecular complex disassembly (GO:0032984)2.94263565
89nuclear-transcribed mRNA catabolic process (GO:0000956)2.93955461
90ubiquinone metabolic process (GO:0006743)2.92922900
91tRNA metabolic process (GO:0006399)2.92572416
92nucleoside triphosphate biosynthetic process (GO:0009142)2.91542396
93replication fork processing (GO:0031297)2.90334605
94histone mRNA metabolic process (GO:0008334)2.90243086
95RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.90079052
96resolution of meiotic recombination intermediates (GO:0000712)2.85222768
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.84115008
98ncRNA metabolic process (GO:0034660)2.83677116
99pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.83379179
100deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.80488475

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.20290945
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.58998673
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.82210409
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.76159286
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66933458
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.48302980
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.32080771
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.30030199
9E2F7_22180533_ChIP-Seq_HELA_Human3.17190265
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79578686
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74047713
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.71230212
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64045912
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63660308
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60812969
16VDR_23849224_ChIP-Seq_CD4+_Human2.60357575
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55518981
18FOXP3_21729870_ChIP-Seq_TREG_Human2.45489885
19VDR_22108803_ChIP-Seq_LS180_Human2.39510989
20ELK1_19687146_ChIP-ChIP_HELA_Human2.33978037
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30406461
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27069703
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18732701
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18062797
25TTF2_22483619_ChIP-Seq_HELA_Human2.16304119
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.13828296
27GABP_19822575_ChIP-Seq_HepG2_Human2.12212307
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11730060
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99517908
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97258568
31ZNF274_21170338_ChIP-Seq_K562_Hela1.93827873
32XRN2_22483619_ChIP-Seq_HELA_Human1.93103734
33MYC_18940864_ChIP-ChIP_HL60_Human1.92831992
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86853353
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81575461
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74676705
37DCP1A_22483619_ChIP-Seq_HELA_Human1.72487482
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69834638
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.68888149
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.67000448
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61728555
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55070619
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47102564
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45335333
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43515324
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43034818
47IRF1_19129219_ChIP-ChIP_H3396_Human1.39663610
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36168401
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32393738
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32324467
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.32133148
52EWS_26573619_Chip-Seq_HEK293_Human1.30976013
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26617583
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23758012
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23188086
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23015782
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20387224
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17381710
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.15141576
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13278236
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12588918
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.09239162
63TP53_22573176_ChIP-Seq_HFKS_Human1.08240256
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08214817
65KDM5A_27292631_Chip-Seq_BREAST_Human1.05532360
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03992751
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03544017
68FUS_26573619_Chip-Seq_HEK293_Human1.02340859
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01437193
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.01322134
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00731944
72MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98633205
73SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93520333
74PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93282998
75SALL1_21062744_ChIP-ChIP_HESCs_Human0.92999561
76ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90223013
77NANOG_20526341_ChIP-Seq_ESCs_Human0.89993991
78FOXP1_21924763_ChIP-Seq_HESCs_Human0.89246448
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89018049
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88815775
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.88815775
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88706295
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87741068
84SOX2_16153702_ChIP-ChIP_HESCs_Human0.87525277
85NCOR_22424771_ChIP-Seq_293T_Human0.87412775
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.87181500
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86869254
88ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86858297
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86217649
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85141059
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84812556
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84620704
93EZH2_22144423_ChIP-Seq_EOC_Human0.82313496
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81834326
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.81580827
96HOXB7_26014856_ChIP-Seq_BT474_Human0.80568547
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76694698
98ERA_21632823_ChIP-Seq_H3396_Human0.76197984
99IGF1R_20145208_ChIP-Seq_DFB_Human0.73788519
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.73782638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.35998754
2MP0009379_abnormal_foot_pigmentation3.44378012
3MP0008789_abnormal_olfactory_epithelium2.96101329
4MP0008058_abnormal_DNA_repair2.69349730
5MP0003693_abnormal_embryo_hatching2.60582573
6MP0003787_abnormal_imprinting2.58380019
7MP0005499_abnormal_olfactory_system2.55028762
8MP0005394_taste/olfaction_phenotype2.55028762
9MP0008877_abnormal_DNA_methylation2.51596333
10MP0002163_abnormal_gland_morphology2.36257436
11MP0004147_increased_porphyrin_level2.28389267
12MP0003123_paternal_imprinting2.16771347
13MP0001293_anophthalmia2.07426949
14MP0002837_dystrophic_cardiac_calcinosis1.97111547
15MP0010030_abnormal_orbit_morphology1.96447815
16MP0002102_abnormal_ear_morphology1.93781721
17MP0005084_abnormal_gallbladder_morpholo1.93779517
18MP0010094_abnormal_chromosome_stability1.93298790
19MP0003121_genomic_imprinting1.88119624
20MP0004957_abnormal_blastocyst_morpholog1.78660361
21MP0002938_white_spotting1.75562512
22MP0006072_abnormal_retinal_apoptosis1.75076175
23MP0001529_abnormal_vocalization1.68523462
24MP0004133_heterotaxia1.61538099
25MP0001188_hyperpigmentation1.58637278
26MP0002736_abnormal_nociception_after1.58316559
27MP0003122_maternal_imprinting1.58182764
28MP0006036_abnormal_mitochondrial_physio1.56850915
29MP0001485_abnormal_pinna_reflex1.54964787
30MP0000049_abnormal_middle_ear1.54324711
31MP0008007_abnormal_cellular_replicative1.51870563
32MP0003195_calcinosis1.48623321
33MP0008872_abnormal_physiological_respon1.47533577
34MP0003786_premature_aging1.46538597
35MP0003111_abnormal_nucleus_morphology1.45953172
36MP0003937_abnormal_limbs/digits/tail_de1.45361052
37MP0002234_abnormal_pharynx_morphology1.43325221
38MP0008932_abnormal_embryonic_tissue1.42838532
39MP0005646_abnormal_pituitary_gland1.37275091
40MP0003718_maternal_effect1.36240005
41MP0002160_abnormal_reproductive_system1.35817899
42MP0006276_abnormal_autonomic_nervous1.35272982
43MP0005379_endocrine/exocrine_gland_phen1.34866353
44MP0003077_abnormal_cell_cycle1.28556198
45MP0008775_abnormal_heart_ventricle1.26902784
46MP0004145_abnormal_muscle_electrophysio1.26088040
47MP0001968_abnormal_touch/_nociception1.24495889
48MP0003186_abnormal_redox_activity1.24007885
49MP0001984_abnormal_olfaction1.22845985
50MP0004142_abnormal_muscle_tone1.21511751
51MP0000631_abnormal_neuroendocrine_gland1.16899655
52MP0003567_abnormal_fetal_cardiomyocyte1.16645834
53MP0005551_abnormal_eye_electrophysiolog1.15558126
54MP0003806_abnormal_nucleotide_metabolis1.14647408
55MP0005389_reproductive_system_phenotype1.12293807
56MP0002210_abnormal_sex_determination1.10234647
57MP0003646_muscle_fatigue1.08297306
58MP0003011_delayed_dark_adaptation1.08180161
59MP0003119_abnormal_digestive_system1.06510941
60MP0003890_abnormal_embryonic-extraembry1.05942979
61MP0009053_abnormal_anal_canal1.04867197
62MP0003878_abnormal_ear_physiology1.02764964
63MP0005377_hearing/vestibular/ear_phenot1.02764964
64MP0002272_abnormal_nervous_system1.02253553
65MP0006035_abnormal_mitochondrial_morpho1.02234201
66MP0001986_abnormal_taste_sensitivity1.00490113
67MP0008875_abnormal_xenobiotic_pharmacok0.99865463
68MP0001348_abnormal_lacrimal_gland0.97953022
69MP0002233_abnormal_nose_morphology0.97890745
70MP0004885_abnormal_endolymph0.97252395
71MP0001905_abnormal_dopamine_level0.97202503
72MP0000372_irregular_coat_pigmentation0.96367790
73MP0005645_abnormal_hypothalamus_physiol0.89966419
74MP0001929_abnormal_gametogenesis0.89456131
75MP0003880_abnormal_central_pattern0.88228815
76MP0005195_abnormal_posterior_eye0.86717032
77MP0005075_abnormal_melanosome_morpholog0.86137701
78MP0002876_abnormal_thyroid_physiology0.86108450
79MP0001145_abnormal_male_reproductive0.85957207
80MP0001286_abnormal_eye_development0.85209138
81MP0005253_abnormal_eye_physiology0.84913541
82MP0000653_abnormal_sex_gland0.84543458
83MP0002277_abnormal_respiratory_mucosa0.83715195
84MP0001919_abnormal_reproductive_system0.82384985
85MP0002184_abnormal_innervation0.82251098
86MP0009046_muscle_twitch0.79498759
87MP0003936_abnormal_reproductive_system0.77754110
88MP0002752_abnormal_somatic_nervous0.75463576
89MP0002638_abnormal_pupillary_reflex0.74227444
90MP0002653_abnormal_ependyma_morphology0.73212326
91MP0005332_abnormal_amino_acid0.72149316
92MP0001119_abnormal_female_reproductive0.71415794
93MP0001764_abnormal_homeostasis0.70253074
94MP0005636_abnormal_mineral_homeostasis0.69642397
95MP0002095_abnormal_skin_pigmentation0.68046009
96MP0005083_abnormal_biliary_tract0.68001353
97MP0004742_abnormal_vestibular_system0.67944841
98MP0003938_abnormal_ear_development0.67701278
99MP0000778_abnormal_nervous_system0.67532019
100MP0005391_vision/eye_phenotype0.66012646

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.83292641
2Acute encephalopathy (HP:0006846)4.44821296
3Abnormal mitochondria in muscle tissue (HP:0008316)4.34207719
4Progressive macrocephaly (HP:0004481)3.92138896
5Mitochondrial inheritance (HP:0001427)3.89920025
6Reticulocytopenia (HP:0001896)3.75694376
7Increased CSF lactate (HP:0002490)3.71758453
83-Methylglutaconic aciduria (HP:0003535)3.67540888
9Colon cancer (HP:0003003)3.31667026
10Cerebral edema (HP:0002181)3.17797175
11Increased hepatocellular lipid droplets (HP:0006565)3.17691117
12Abnormality of cells of the erythroid lineage (HP:0012130)3.16215507
13Molar tooth sign on MRI (HP:0002419)3.14193887
14Abnormality of midbrain morphology (HP:0002418)3.14193887
15Hepatocellular necrosis (HP:0001404)3.11781517
16Pancreatic cysts (HP:0001737)2.98904133
17Pancreatic fibrosis (HP:0100732)2.95729577
18Macrocytic anemia (HP:0001972)2.89716768
19Increased serum lactate (HP:0002151)2.88395799
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88310909
21Abnormality of alanine metabolism (HP:0010916)2.88310909
22Hyperalaninemia (HP:0003348)2.88310909
23Lipid accumulation in hepatocytes (HP:0006561)2.87182961
24Abnormal number of erythroid precursors (HP:0012131)2.74401198
25Hepatic necrosis (HP:0002605)2.72249581
26Adrenal hypoplasia (HP:0000835)2.68367037
27Nephronophthisis (HP:0000090)2.68066905
28Hyperglycinemia (HP:0002154)2.67776725
29Lactic acidosis (HP:0003128)2.65415951
30Renal Fanconi syndrome (HP:0001994)2.64320014
31Abnormality of the labia minora (HP:0012880)2.57978684
32Absent thumb (HP:0009777)2.53196651
33Sclerocornea (HP:0000647)2.47276189
34Optic disc pallor (HP:0000543)2.38263321
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32853484
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32853484
37Aplasia/Hypoplasia of the spleen (HP:0010451)2.31983722
38Leukodystrophy (HP:0002415)2.30993442
39Increased intramyocellular lipid droplets (HP:0012240)2.30320037
40Tubular atrophy (HP:0000092)2.30155362
41Asplenia (HP:0001746)2.30031711
42True hermaphroditism (HP:0010459)2.29076725
43Abnormality of the renal medulla (HP:0100957)2.23288308
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22854320
45Septo-optic dysplasia (HP:0100842)2.21747033
46Pendular nystagmus (HP:0012043)2.20516956
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.20051602
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16799669
49Exercise intolerance (HP:0003546)2.16692726
50Ectopic kidney (HP:0000086)2.15374470
51Type II lissencephaly (HP:0007260)2.12306116
52Congenital stationary night blindness (HP:0007642)2.11715706
53Respiratory failure (HP:0002878)2.11374647
54Meckel diverticulum (HP:0002245)2.10305698
55Microretrognathia (HP:0000308)2.09618678
56Medial flaring of the eyebrow (HP:0010747)2.07904899
57Abnormal biliary tract physiology (HP:0012439)2.07070344
58Bile duct proliferation (HP:0001408)2.07070344
59Respiratory difficulties (HP:0002880)2.06484888
60Abnormal rod and cone electroretinograms (HP:0008323)2.05410114
61Supernumerary spleens (HP:0009799)2.05238361
62Horseshoe kidney (HP:0000085)2.04099640
63Triphalangeal thumb (HP:0001199)2.03256583
64Lethargy (HP:0001254)2.02295379
65Methylmalonic acidemia (HP:0002912)2.01813010
66Methylmalonic aciduria (HP:0012120)2.01636219
67Pallor (HP:0000980)2.01320049
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00805049
69Absent/shortened dynein arms (HP:0200106)2.00148627
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.00148627
71Exertional dyspnea (HP:0002875)1.99710261
72Abnormality of the ileum (HP:0001549)1.99242142
73Anencephaly (HP:0002323)1.98550957
74Hyperglycinuria (HP:0003108)1.96476217
75Abnormality of the renal cortex (HP:0011035)1.94511939
76Congenital, generalized hypertrichosis (HP:0004540)1.94334028
77Abnormality of serum amino acid levels (HP:0003112)1.93448309
78Abolished electroretinogram (ERG) (HP:0000550)1.91331104
79Double outlet right ventricle (HP:0001719)1.90122863
80Congenital malformation of the right heart (HP:0011723)1.90122863
81Abnormality of the pons (HP:0007361)1.89666731
82Abnormal drinking behavior (HP:0030082)1.87800323
83Polydipsia (HP:0001959)1.87800323
84Abnormality of serine family amino acid metabolism (HP:0010894)1.86179553
85Abnormality of glycine metabolism (HP:0010895)1.86179553
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84967548
87Testicular atrophy (HP:0000029)1.83877195
88Hypoplasia of the pons (HP:0012110)1.83617349
89Type 2 muscle fiber atrophy (HP:0003554)1.83605633
90Anophthalmia (HP:0000528)1.82301244
91Abnormal number of incisors (HP:0011064)1.81260846
92Chromsome breakage (HP:0040012)1.81005225
93Pancytopenia (HP:0001876)1.80371501
94Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79007040
95Increased muscle lipid content (HP:0009058)1.77726800
96Postaxial foot polydactyly (HP:0001830)1.77300667
97Abnormal lung lobation (HP:0002101)1.74916996
98Rib fusion (HP:0000902)1.73639356
99Abnormality of the preputium (HP:0100587)1.73559007
100Optic nerve coloboma (HP:0000588)1.73454599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK12.87832021
2NUAK12.80763867
3CDC72.69543409
4STK162.66125300
5TSSK62.59193501
6ZAK2.55933624
7BUB12.50472300
8MKNK22.47562484
9VRK22.44099916
10WNK42.41475596
11WNK32.14325403
12BCKDK2.01862926
13NME22.01299954
14TIE11.95936450
15PLK31.94656120
16PLK41.90013494
17EIF2AK11.79671925
18ADRBK21.78381287
19GRK11.75828023
20MKNK11.70366132
21TLK11.68746300
22BMPR1B1.58876424
23STK391.57731031
24MAP4K21.51684610
25TAF11.51381082
26TTK1.46274467
27OXSR11.41009319
28SRPK11.38732542
29TRIM281.31142859
30PLK11.27981459
31PIK3CA1.25114800
32TNIK1.22992182
33VRK11.22733930
34DYRK21.22115248
35ACVR1B1.15328621
36MAP2K71.12849657
37TXK1.12744483
38MST41.12046651
39FRK1.11494593
40PDK21.04178760
41EIF2AK31.00389042
42MAP3K111.00243482
43CSNK1G20.98041005
44CHEK20.97950741
45EPHA40.97588046
46TEC0.97218440
47CSNK1G30.96996915
48ALK0.95618140
49AURKB0.93696438
50PINK10.93333624
51ATR0.89111037
52CDK190.88400945
53CSNK1G10.88148620
54WEE10.85023002
55PRKCG0.83987968
56NME10.83781901
57DYRK30.83374465
58MAP3K40.82089292
59BRSK20.81740451
60PASK0.81616364
61EIF2AK20.80609160
62CSNK1A1L0.76576770
63BRAF0.72968057
64AURKA0.71976124
65TAOK30.71732245
66CSNK2A20.69934607
67BRSK10.66980940
68INSRR0.65504647
69CSNK1E0.61975246
70PHKG20.61762718
71PHKG10.61762718
72CSNK2A10.60525845
73NEK20.60402755
74PRKCI0.59331128
75ATM0.58978745
76IKBKB0.58691061
77PBK0.58387964
78ITK0.54774268
79CAMKK20.52310917
80ABL20.52287234
81TGFBR10.51883269
82CHEK10.51112375
83RPS6KA50.49185960
84CSNK1A10.47970313
85ADRBK10.47931705
86STK110.46326912
87PLK20.45519716
88PNCK0.43113358
89LRRK20.42939692
90PAK30.41911958
91DMPK0.41521759
92MINK10.41489663
93MAP3K120.38330491
94PRKACA0.38109967
95PRKDC0.36742983
96CASK0.35837360
97CAMK10.34533397
98DAPK10.32994908
99NTRK20.31722286
100PRKCE0.31069611

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.71799333
2Oxidative phosphorylation_Homo sapiens_hsa001903.56810039
3Proteasome_Homo sapiens_hsa030503.39793294
4Parkinsons disease_Homo sapiens_hsa050123.00470120
5RNA polymerase_Homo sapiens_hsa030202.95082904
6Protein export_Homo sapiens_hsa030602.77470352
7Mismatch repair_Homo sapiens_hsa034302.72663868
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61443648
9Homologous recombination_Homo sapiens_hsa034402.54481096
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.47384816
11One carbon pool by folate_Homo sapiens_hsa006702.36348285
12DNA replication_Homo sapiens_hsa030302.30413223
13Huntingtons disease_Homo sapiens_hsa050162.19032491
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06893492
15Fanconi anemia pathway_Homo sapiens_hsa034602.06886184
16Alzheimers disease_Homo sapiens_hsa050101.96069675
17RNA degradation_Homo sapiens_hsa030181.90545851
18Basal transcription factors_Homo sapiens_hsa030221.89315499
19Pyrimidine metabolism_Homo sapiens_hsa002401.76266661
20RNA transport_Homo sapiens_hsa030131.64797770
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62845730
22Nucleotide excision repair_Homo sapiens_hsa034201.61942731
23Sulfur relay system_Homo sapiens_hsa041221.60738966
24Cardiac muscle contraction_Homo sapiens_hsa042601.56798090
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56263925
26Spliceosome_Homo sapiens_hsa030401.53613743
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53587859
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52341407
29Non-homologous end-joining_Homo sapiens_hsa034501.52258044
30Propanoate metabolism_Homo sapiens_hsa006401.46119621
31Vitamin B6 metabolism_Homo sapiens_hsa007501.38304944
32Base excision repair_Homo sapiens_hsa034101.37519295
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.35645122
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34254562
35Purine metabolism_Homo sapiens_hsa002301.25657513
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18847680
37Selenocompound metabolism_Homo sapiens_hsa004501.09315657
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08755020
39Phototransduction_Homo sapiens_hsa047441.07955439
40Linoleic acid metabolism_Homo sapiens_hsa005911.06151311
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02403765
42Steroid biosynthesis_Homo sapiens_hsa001000.97541211
43Asthma_Homo sapiens_hsa053100.96139117
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89913427
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89727207
46Fatty acid elongation_Homo sapiens_hsa000620.89233668
47Sulfur metabolism_Homo sapiens_hsa009200.88408889
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87535607
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85414170
50Metabolic pathways_Homo sapiens_hsa011000.82794913
51Tryptophan metabolism_Homo sapiens_hsa003800.80923199
52Folate biosynthesis_Homo sapiens_hsa007900.78443627
53Fat digestion and absorption_Homo sapiens_hsa049750.76794114
54Peroxisome_Homo sapiens_hsa041460.71648537
55Pyruvate metabolism_Homo sapiens_hsa006200.69844801
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65077155
57p53 signaling pathway_Homo sapiens_hsa041150.64592426
58Glutathione metabolism_Homo sapiens_hsa004800.64411793
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64075029
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60580369
61Cell cycle_Homo sapiens_hsa041100.59738861
62Arachidonic acid metabolism_Homo sapiens_hsa005900.59575272
63Butanoate metabolism_Homo sapiens_hsa006500.59351942
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57744453
65Basal cell carcinoma_Homo sapiens_hsa052170.55937595
66Ether lipid metabolism_Homo sapiens_hsa005650.55883776
67Olfactory transduction_Homo sapiens_hsa047400.49972184
68Caffeine metabolism_Homo sapiens_hsa002320.49224020
69Nitrogen metabolism_Homo sapiens_hsa009100.49020899
70Retinol metabolism_Homo sapiens_hsa008300.47833640
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47358605
72Hedgehog signaling pathway_Homo sapiens_hsa043400.46389433
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.45628364
74Chemical carcinogenesis_Homo sapiens_hsa052040.44711335
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.43944405
76beta-Alanine metabolism_Homo sapiens_hsa004100.42635718
77Fatty acid degradation_Homo sapiens_hsa000710.42547942
78Collecting duct acid secretion_Homo sapiens_hsa049660.41938725
79mRNA surveillance pathway_Homo sapiens_hsa030150.41365155
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36842130
81Carbon metabolism_Homo sapiens_hsa012000.36747184
82Regulation of autophagy_Homo sapiens_hsa041400.35485487
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.33023959
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.32360543
85Nicotine addiction_Homo sapiens_hsa050330.32173142
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29704131
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29430464
88Biosynthesis of amino acids_Homo sapiens_hsa012300.29222180
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26869317
90Fatty acid metabolism_Homo sapiens_hsa012120.26277726
91Allograft rejection_Homo sapiens_hsa053300.25060688
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24782817
93Arginine and proline metabolism_Homo sapiens_hsa003300.24400947
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23825072
95Autoimmune thyroid disease_Homo sapiens_hsa053200.23011234
96Primary immunodeficiency_Homo sapiens_hsa053400.20816333
97Type I diabetes mellitus_Homo sapiens_hsa049400.20286660
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20240997
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19892890
100Epstein-Barr virus infection_Homo sapiens_hsa051690.17715859

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