SNRPEP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.36089201
2ATP synthesis coupled proton transport (GO:0015986)4.99527928
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.99527928
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.70650996
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.53093880
6protein neddylation (GO:0045116)4.52872066
7protein complex biogenesis (GO:0070271)4.27538871
8kynurenine metabolic process (GO:0070189)4.22103367
9respiratory electron transport chain (GO:0022904)4.04419516
10electron transport chain (GO:0022900)4.02647061
11tryptophan catabolic process (GO:0006569)4.02291493
12indole-containing compound catabolic process (GO:0042436)4.02291493
13indolalkylamine catabolic process (GO:0046218)4.02291493
14tryptophan metabolic process (GO:0006568)3.95529012
15base-excision repair, AP site formation (GO:0006285)3.94825985
16mitochondrial respiratory chain complex assembly (GO:0033108)3.89087357
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.85107608
18regulation of cilium movement (GO:0003352)3.80521613
19indolalkylamine metabolic process (GO:0006586)3.78643699
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.78107087
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.78107087
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66695163
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.66695163
24NADH dehydrogenase complex assembly (GO:0010257)3.66695163
25ribosomal small subunit assembly (GO:0000028)3.65586106
26preassembly of GPI anchor in ER membrane (GO:0016254)3.60782975
27respiratory chain complex IV assembly (GO:0008535)3.59491432
28cytochrome complex assembly (GO:0017004)3.51003499
29protein-cofactor linkage (GO:0018065)3.49322980
30RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.47586889
31chaperone-mediated protein transport (GO:0072321)3.45408800
32maturation of 5.8S rRNA (GO:0000460)3.37818703
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36339226
34mannosylation (GO:0097502)3.36282837
35piRNA metabolic process (GO:0034587)3.34525604
36oxidative phosphorylation (GO:0006119)3.26460893
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.26013421
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25174459
39L-fucose catabolic process (GO:0042355)3.20435427
40fucose catabolic process (GO:0019317)3.20435427
41L-fucose metabolic process (GO:0042354)3.20435427
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18082056
43ATP biosynthetic process (GO:0006754)3.14287420
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.07075953
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.05793224
46GPI anchor metabolic process (GO:0006505)3.03544487
47hydrogen ion transmembrane transport (GO:1902600)3.00020803
48GPI anchor biosynthetic process (GO:0006506)2.99942254
49rRNA catabolic process (GO:0016075)2.99828459
50spliceosomal complex assembly (GO:0000245)2.99384349
51establishment of protein localization to mitochondrial membrane (GO:0090151)2.98220547
52aldehyde catabolic process (GO:0046185)2.97827259
53protein polyglutamylation (GO:0018095)2.95561869
54negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.93296088
55L-methionine salvage (GO:0071267)2.89966131
56L-methionine biosynthetic process (GO:0071265)2.89966131
57amino acid salvage (GO:0043102)2.89966131
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89671911
59regulation of cellular amino acid metabolic process (GO:0006521)2.89176214
60behavioral response to nicotine (GO:0035095)2.87990617
61transcription elongation from RNA polymerase III promoter (GO:0006385)2.87804265
62termination of RNA polymerase III transcription (GO:0006386)2.87804265
63S-adenosylmethionine metabolic process (GO:0046500)2.87657592
64proton transport (GO:0015992)2.84085917
65amine catabolic process (GO:0009310)2.83772522
66cellular biogenic amine catabolic process (GO:0042402)2.83772522
67hydrogen transport (GO:0006818)2.81846797
68ubiquinone biosynthetic process (GO:0006744)2.81138797
69proteasome assembly (GO:0043248)2.80653544
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80476074
71GTP biosynthetic process (GO:0006183)2.78894936
72branched-chain amino acid catabolic process (GO:0009083)2.78165040
73positive regulation of prostaglandin secretion (GO:0032308)2.77934456
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.75975680
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.75975680
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.75975680
77negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.72503794
78tRNA processing (GO:0008033)2.70973961
79maturation of SSU-rRNA (GO:0030490)2.69986448
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67723994
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67723994
82mast cell activation involved in immune response (GO:0002279)2.63361977
83mast cell degranulation (GO:0043303)2.63361977
84regulation of microtubule-based movement (GO:0060632)2.62877975
85axoneme assembly (GO:0035082)2.62213540
86epithelial cilium movement (GO:0003351)2.61490178
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59641059
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.57690491
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.57690491
90signal transduction involved in cell cycle checkpoint (GO:0072395)2.57213850
91deoxyribonucleotide catabolic process (GO:0009264)2.57140746
92RNA phosphodiester bond hydrolysis (GO:0090501)2.55766062
93indole-containing compound metabolic process (GO:0042430)2.54991352
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.53071647
95cytidine metabolic process (GO:0046087)2.53071609
96cytidine catabolic process (GO:0006216)2.53071609
97cytidine deamination (GO:0009972)2.53071609
98somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.51808062
99isotype switching (GO:0045190)2.51808062
100somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.51808062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.10183341
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.95045730
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.55691569
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.42580473
5ZNF274_21170338_ChIP-Seq_K562_Hela3.21848396
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.15029932
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98145395
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94605550
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77563940
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73389468
11VDR_23849224_ChIP-Seq_CD4+_Human2.65171220
12VDR_22108803_ChIP-Seq_LS180_Human2.63222765
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.52462859
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50893004
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.30877020
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.25664475
17ELK1_19687146_ChIP-ChIP_HELA_Human2.20048059
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16362622
19FOXP3_21729870_ChIP-Seq_TREG_Human2.02891430
20MYC_18940864_ChIP-ChIP_HL60_Human1.85100290
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84218065
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83671928
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.81287124
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.81182210
25IGF1R_20145208_ChIP-Seq_DFB_Human1.80994577
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68796220
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65757112
28IRF1_19129219_ChIP-ChIP_H3396_Human1.65658009
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60891680
30EWS_26573619_Chip-Seq_HEK293_Human1.60649977
31TP53_22573176_ChIP-Seq_HFKS_Human1.60566151
32FUS_26573619_Chip-Seq_HEK293_Human1.59218245
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57556658
34AR_20517297_ChIP-Seq_VCAP_Human1.52668832
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.52389461
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.52389461
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48767771
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43973023
39TAF15_26573619_Chip-Seq_HEK293_Human1.38160405
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.35236403
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34720976
42GATA3_26560356_Chip-Seq_TH2_Human1.32257305
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32241216
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31263644
45EZH2_22144423_ChIP-Seq_EOC_Human1.30952233
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.30392589
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29425085
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29270505
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26757673
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26733939
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26277891
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.24422396
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23636705
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23286827
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22310700
56GABP_19822575_ChIP-Seq_HepG2_Human1.21604622
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21393512
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19397215
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18482247
60SOX2_19829295_ChIP-Seq_ESCs_Human1.18429183
61NANOG_19829295_ChIP-Seq_ESCs_Human1.18429183
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.17955068
63P300_19829295_ChIP-Seq_ESCs_Human1.17733467
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17668612
65ER_23166858_ChIP-Seq_MCF-7_Human1.15593274
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14622249
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13599452
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13294474
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12869861
70CBP_20019798_ChIP-Seq_JUKART_Human1.12869861
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12499460
72ERG_20517297_ChIP-Seq_VCAP_Human1.12029513
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10104965
74TTF2_22483619_ChIP-Seq_HELA_Human1.09768044
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09002776
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.08643878
77CIITA_25753668_ChIP-Seq_RAJI_Human1.07569592
78FOXH1_21741376_ChIP-Seq_EPCs_Human1.06499409
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06011760
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05977407
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05108501
82HOXB7_26014856_ChIP-Seq_BT474_Human1.04442883
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03680084
84NANOG_20526341_ChIP-Seq_ESCs_Human1.03622415
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03172758
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03080291
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02926894
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01623392
89TAF2_19829295_ChIP-Seq_ESCs_Human1.01100107
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00597896
91NCOR_22424771_ChIP-Seq_293T_Human1.00568790
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00518599
93IRF8_21731497_ChIP-ChIP_J774_Mouse0.98957939
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.98941468
95SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97349510
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96383827
97E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96201820
98MYC_19829295_ChIP-Seq_ESCs_Human0.95018111
99DCP1A_22483619_ChIP-Seq_HELA_Human0.92475855
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91697563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.08165457
2MP0004147_increased_porphyrin_level2.99774049
3MP0006072_abnormal_retinal_apoptosis2.93294272
4MP0008877_abnormal_DNA_methylation2.87974596
5MP0005646_abnormal_pituitary_gland2.52786591
6MP0003195_calcinosis2.36128359
7MP0008875_abnormal_xenobiotic_pharmacok2.28665606
8MP0005084_abnormal_gallbladder_morpholo2.26354184
9MP0003787_abnormal_imprinting2.16077910
10MP0008872_abnormal_physiological_respon2.15877095
11MP0002876_abnormal_thyroid_physiology2.11370218
12MP0005671_abnormal_response_to2.04957771
13MP0008995_early_reproductive_senescence1.99052258
14MP0001835_abnormal_antigen_presentation1.97098733
15MP0005075_abnormal_melanosome_morpholog1.96345372
16MP0004885_abnormal_endolymph1.94234129
17MP0005645_abnormal_hypothalamus_physiol1.92052054
18MP0002837_dystrophic_cardiac_calcinosis1.91493058
19MP0008058_abnormal_DNA_repair1.90763731
20MP0002102_abnormal_ear_morphology1.89129708
21MP0005551_abnormal_eye_electrophysiolog1.86817798
22MP0003786_premature_aging1.83010894
23MP0002234_abnormal_pharynx_morphology1.77889493
24MP0008775_abnormal_heart_ventricle1.75456493
25MP0000372_irregular_coat_pigmentation1.73539140
26MP0003724_increased_susceptibility_to1.72695296
27MP0004145_abnormal_muscle_electrophysio1.72303150
28MP0006036_abnormal_mitochondrial_physio1.65428707
29MP0003011_delayed_dark_adaptation1.59253664
30MP0005253_abnormal_eye_physiology1.58118031
31MP0003646_muscle_fatigue1.56088093
32MP0006276_abnormal_autonomic_nervous1.49654470
33MP0002148_abnormal_hypersensitivity_rea1.48538186
34MP0009046_muscle_twitch1.46572997
35MP0002138_abnormal_hepatobiliary_system1.43830177
36MP0005389_reproductive_system_phenotype1.40653213
37MP0004142_abnormal_muscle_tone1.40253572
38MP0009764_decreased_sensitivity_to1.39211328
39MP0009379_abnormal_foot_pigmentation1.37133930
40MP0002272_abnormal_nervous_system1.37073257
41MP0002736_abnormal_nociception_after1.35975319
42MP0001986_abnormal_taste_sensitivity1.34864110
43MP0006054_spinal_hemorrhage1.34402879
44MP0002163_abnormal_gland_morphology1.28373158
45MP0003252_abnormal_bile_duct1.28273476
46MP0001919_abnormal_reproductive_system1.27794000
47MP0001968_abnormal_touch/_nociception1.26993988
48MP0003186_abnormal_redox_activity1.26280659
49MP0001764_abnormal_homeostasis1.26276098
50MP0002160_abnormal_reproductive_system1.14531182
51MP0002006_tumorigenesis1.14358502
52MP0001800_abnormal_humoral_immune1.11689927
53MP0001501_abnormal_sleep_pattern1.10263060
54MP0003806_abnormal_nucleotide_metabolis1.09894715
55MP0003866_abnormal_defecation1.07141185
56MP0009785_altered_susceptibility_to1.07030378
57MP0006035_abnormal_mitochondrial_morpho1.06482940
58MP0005000_abnormal_immune_tolerance1.05875163
59MP0000230_abnormal_systemic_arterial1.05588430
60MP0003878_abnormal_ear_physiology1.03738337
61MP0005377_hearing/vestibular/ear_phenot1.03738337
62MP0005367_renal/urinary_system_phenotyp1.02363456
63MP0000516_abnormal_urinary_system1.02363456
64MP0000631_abnormal_neuroendocrine_gland1.01862457
65MP0001905_abnormal_dopamine_level1.00681523
66MP0005167_abnormal_blood-brain_barrier1.00327996
67MP0005636_abnormal_mineral_homeostasis1.00103458
68MP0003880_abnormal_central_pattern0.99791142
69MP0002166_altered_tumor_susceptibility0.99653933
70MP0002928_abnormal_bile_duct0.97760587
71MP0001542_abnormal_bone_strength0.97019806
72MP0005332_abnormal_amino_acid0.96556225
73MP0008789_abnormal_olfactory_epithelium0.95753899
74MP0003718_maternal_effect0.94277852
75MP0009745_abnormal_behavioral_response0.93777535
76MP0009333_abnormal_splenocyte_physiolog0.93501756
77MP0001293_anophthalmia0.92577655
78MP0001970_abnormal_pain_threshold0.92553538
79MP0010386_abnormal_urinary_bladder0.91262649
80MP0001529_abnormal_vocalization0.90438238
81MP0002723_abnormal_immune_serum0.90275196
82MP0001765_abnormal_ion_homeostasis0.89846821
83MP0002733_abnormal_thermal_nociception0.88917308
84MP0005085_abnormal_gallbladder_physiolo0.87412218
85MP0005410_abnormal_fertilization0.86708930
86MP0002452_abnormal_antigen_presenting0.86439786
87MP0002277_abnormal_respiratory_mucosa0.79681006
88MP0003121_genomic_imprinting0.79662567
89MP0003137_abnormal_impulse_conducting0.77049866
90MP0004215_abnormal_myocardial_fiber0.76735493
91MP0001485_abnormal_pinna_reflex0.75386977
92MP0001756_abnormal_urination0.75253352
93MP0001440_abnormal_grooming_behavior0.74732582
94MP0002572_abnormal_emotion/affect_behav0.73652436
95MP0001819_abnormal_immune_cell0.71995495
96MP0001984_abnormal_olfaction0.70601521
97MP0009780_abnormal_chondrocyte_physiolo0.70403585
98MP0002282_abnormal_trachea_morphology0.70147985
99MP0002751_abnormal_autonomic_nervous0.69638537
100MP0002420_abnormal_adaptive_immunity0.69561388

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.42651086
2Acute encephalopathy (HP:0006846)4.29048595
3Mitochondrial inheritance (HP:0001427)4.21732904
4Abnormal mitochondria in muscle tissue (HP:0008316)4.09907578
5Hepatocellular necrosis (HP:0001404)4.06339015
6Increased CSF lactate (HP:0002490)3.91562690
7Hepatic necrosis (HP:0002605)3.79197265
8Progressive macrocephaly (HP:0004481)3.68641263
9Congenital, generalized hypertrichosis (HP:0004540)3.66038877
103-Methylglutaconic aciduria (HP:0003535)3.55024240
11Pancreatic cysts (HP:0001737)3.37690358
12Attenuation of retinal blood vessels (HP:0007843)3.23621556
13Decreased electroretinogram (ERG) amplitude (HP:0000654)3.20700344
14Nephronophthisis (HP:0000090)3.09509680
15Lipid accumulation in hepatocytes (HP:0006561)2.98879489
16Abnormality of midbrain morphology (HP:0002418)2.96999126
17Molar tooth sign on MRI (HP:0002419)2.96999126
18Cerebral edema (HP:0002181)2.94203850
19Pancreatic fibrosis (HP:0100732)2.92258839
20Increased hepatocellular lipid droplets (HP:0006565)2.92044242
21Optic disc pallor (HP:0000543)2.89922279
22Absent/shortened dynein arms (HP:0200106)2.86596650
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.86596650
24Congenital stationary night blindness (HP:0007642)2.83070616
25Lactic acidosis (HP:0003128)2.80296037
26Abolished electroretinogram (ERG) (HP:0000550)2.78847180
27Increased serum lactate (HP:0002151)2.72997827
28Abnormality of the renal medulla (HP:0100957)2.68767292
29Abnormality of the renal cortex (HP:0011035)2.67122445
30Abnormal rod and cone electroretinograms (HP:0008323)2.65593666
31Medial flaring of the eyebrow (HP:0010747)2.59107561
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58910350
33True hermaphroditism (HP:0010459)2.56331501
34Increased intramyocellular lipid droplets (HP:0012240)2.53954537
35IgG deficiency (HP:0004315)2.52046766
36Hyperglycinuria (HP:0003108)2.50862694
37Constricted visual fields (HP:0001133)2.50562564
38Hyperglycinemia (HP:0002154)2.50304071
39Renal cortical cysts (HP:0000803)2.46444711
40Methylmalonic acidemia (HP:0002912)2.39762284
41Type II lissencephaly (HP:0007260)2.37051822
42Decreased central vision (HP:0007663)2.37017083
43Sclerocornea (HP:0000647)2.34955804
44Abnormal respiratory epithelium morphology (HP:0012253)2.33744600
45Abnormal respiratory motile cilium morphology (HP:0005938)2.33744600
46Respiratory failure (HP:0002878)2.31602389
47Abnormality of the prostate (HP:0008775)2.31240615
48Renal Fanconi syndrome (HP:0001994)2.30364378
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27778426
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27778426
51Lethargy (HP:0001254)2.24145887
52Increased muscle lipid content (HP:0009058)2.23468479
53Stomach cancer (HP:0012126)2.22261897
54Aplasia/hypoplasia of the uterus (HP:0008684)2.19541479
55Hypoproteinemia (HP:0003075)2.17492995
56Abnormality of B cell number (HP:0010975)2.16757259
57Testicular atrophy (HP:0000029)2.16472596
58Hypothermia (HP:0002045)2.15165135
59Elevated erythrocyte sedimentation rate (HP:0003565)2.13245646
60Methylmalonic aciduria (HP:0012120)2.08380091
61Abnormal drinking behavior (HP:0030082)2.03434246
62Polydipsia (HP:0001959)2.03434246
63CNS demyelination (HP:0007305)2.01202052
64Delayed CNS myelination (HP:0002188)2.00421373
65Abnormality of glycine metabolism (HP:0010895)2.00257702
66Abnormality of serine family amino acid metabolism (HP:0010894)2.00257702
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96400618
68Aplasia/Hypoplasia of the spleen (HP:0010451)1.95980570
69Hypoplasia of the uterus (HP:0000013)1.94502486
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91747195
71Exercise intolerance (HP:0003546)1.91411739
72Colon cancer (HP:0003003)1.90077118
73Exertional dyspnea (HP:0002875)1.87985447
74Abnormal protein glycosylation (HP:0012346)1.87389140
75Abnormal glycosylation (HP:0012345)1.87389140
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87389140
77Abnormal protein N-linked glycosylation (HP:0012347)1.87389140
78Asplenia (HP:0001746)1.85602144
79Abnormal ciliary motility (HP:0012262)1.84365079
80Abnormality of cells of the erythroid lineage (HP:0012130)1.82643563
81Ketosis (HP:0001946)1.81977419
82Abnormal biliary tract physiology (HP:0012439)1.81287506
83Bile duct proliferation (HP:0001408)1.81287506
84Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81223090
85Dicarboxylic aciduria (HP:0003215)1.81223090
86Cerebral palsy (HP:0100021)1.81076998
87Glycosuria (HP:0003076)1.80086458
88Abnormality of urine glucose concentration (HP:0011016)1.80086458
89Severe combined immunodeficiency (HP:0004430)1.79842490
90Abnormal number of erythroid precursors (HP:0012131)1.79535335
91Abnormality of the proximal phalanges of the hand (HP:0009834)1.79126338
92Congenital hepatic fibrosis (HP:0002612)1.79040080
93Abnormality of serum amino acid levels (HP:0003112)1.78286236
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77534437
95Absent thumb (HP:0009777)1.77103003
96Type I transferrin isoform profile (HP:0003642)1.74365936
97Emotional lability (HP:0000712)1.72821755
98Cystic liver disease (HP:0006706)1.71725413
99Progressive microcephaly (HP:0000253)1.71599215
100Leukodystrophy (HP:0002415)1.71485742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.27283122
2TLK12.94886960
3MAP4K22.69292194
4STK162.68825258
5NUAK12.55706614
6FRK2.55090814
7BCKDK2.54530350
8TAOK32.45950980
9CDK192.38991621
10VRK22.38535378
11TIE12.36817601
12GRK12.18322118
13ADRBK22.09535102
14TXK2.09055131
15MAP3K121.96104219
16KIT1.90601613
17BMPR1B1.76650184
18NEK11.72826101
19WNK41.67231939
20CSNK1G31.50172504
21TRPM71.48376643
22CAMKK21.44221939
23PINK11.41646484
24EIF2AK31.37173518
25CSNK1G21.37062881
26KDR1.33655972
27PHKG21.32728618
28PHKG11.32728618
29MST41.32299981
30WNK31.30831868
31VRK11.28726173
32MAPKAPK31.26996088
33CSNK1A1L1.26735970
34CSNK1G11.20313346
35OXSR11.14908912
36TEC1.13134079
37DAPK11.10016220
38MAP2K71.08140743
39RPS6KA51.07247594
40GRK61.03170835
41IKBKB1.01146770
42ITK1.00978212
43BMPR20.99877352
44ERBB30.95987840
45MKNK10.91368832
46FLT30.89543730
47MAP3K40.87085554
48MAPKAPK50.86860495
49MYLK0.86249316
50INSRR0.85876807
51EPHA30.83934801
52PLK40.83623734
53DAPK20.82783372
54NME20.82681213
55MAPK130.81421347
56LIMK10.79353770
57PLK30.79260425
58PLK20.76880269
59TRIM280.74161544
60MAP4K10.71464525
61MATK0.67806357
62GRK70.67244056
63STK390.66878755
64ACVR1B0.66173816
65SYK0.66106013
66MAP2K20.63873393
67BTK0.57467893
68DYRK20.55380566
69SCYL20.54304324
70ABL20.52812835
71FES0.52789694
72RPS6KA40.52230862
73CAMKK10.49247774
74PASK0.49165652
75IGF1R0.48425479
76LYN0.48123007
77BRSK20.47638289
78BUB10.46976834
79CSF1R0.45866707
80EIF2AK10.45559945
81GRK50.44189459
82CDK80.43571118
83PRKCE0.43548015
84ADRBK10.42915638
85ATR0.42616907
86MUSK0.41465945
87PRKCQ0.40058334
88FER0.39599263
89TAF10.38106503
90PIK3CA0.37819034
91IKBKE0.37602793
92DAPK30.37590966
93CSNK1A10.37311071
94MAP3K140.36670636
95LCK0.36630625
96ABL10.35778805
97CSNK2A10.35702430
98ILK0.35417567
99JAK30.34606189
100CSNK2A20.33951329

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.67028534
2Proteasome_Homo sapiens_hsa030503.54702879
3Asthma_Homo sapiens_hsa053103.13769443
4Parkinsons disease_Homo sapiens_hsa050122.96576362
5Allograft rejection_Homo sapiens_hsa053302.64585012
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.56537930
7Ribosome_Homo sapiens_hsa030102.49963365
8Graft-versus-host disease_Homo sapiens_hsa053322.38107963
9Autoimmune thyroid disease_Homo sapiens_hsa053202.37531310
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34958174
11Type I diabetes mellitus_Homo sapiens_hsa049402.22263362
12Protein export_Homo sapiens_hsa030602.21848730
13Caffeine metabolism_Homo sapiens_hsa002322.06443800
14RNA polymerase_Homo sapiens_hsa030202.02841971
15Alzheimers disease_Homo sapiens_hsa050101.99349749
16Homologous recombination_Homo sapiens_hsa034401.88272394
17Huntingtons disease_Homo sapiens_hsa050161.85492729
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79116915
19Phototransduction_Homo sapiens_hsa047441.78637046
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68971860
21Propanoate metabolism_Homo sapiens_hsa006401.57441082
22Cardiac muscle contraction_Homo sapiens_hsa042601.56005932
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55645270
24Tryptophan metabolism_Homo sapiens_hsa003801.50399242
25RNA degradation_Homo sapiens_hsa030181.46754465
26Linoleic acid metabolism_Homo sapiens_hsa005911.45380690
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44518080
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39847645
29Non-homologous end-joining_Homo sapiens_hsa034501.39546427
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39163517
31Rheumatoid arthritis_Homo sapiens_hsa053231.31126438
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22295678
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21602566
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21340150
35Antigen processing and presentation_Homo sapiens_hsa046121.19261260
36Mismatch repair_Homo sapiens_hsa034301.18778077
37Basal transcription factors_Homo sapiens_hsa030221.18106714
38One carbon pool by folate_Homo sapiens_hsa006701.17988542
39Base excision repair_Homo sapiens_hsa034101.15460390
40Fanconi anemia pathway_Homo sapiens_hsa034601.12598380
41Nitrogen metabolism_Homo sapiens_hsa009101.11607744
42Primary immunodeficiency_Homo sapiens_hsa053401.07761179
43Peroxisome_Homo sapiens_hsa041461.05749368
44DNA replication_Homo sapiens_hsa030301.04267566
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03252151
46Ether lipid metabolism_Homo sapiens_hsa005650.97696758
47Arachidonic acid metabolism_Homo sapiens_hsa005900.95875730
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.94025729
49Purine metabolism_Homo sapiens_hsa002300.92867237
50Chemical carcinogenesis_Homo sapiens_hsa052040.90608496
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87675928
52Pyrimidine metabolism_Homo sapiens_hsa002400.86889153
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84747947
54Butanoate metabolism_Homo sapiens_hsa006500.81932136
55Nucleotide excision repair_Homo sapiens_hsa034200.81641457
56Spliceosome_Homo sapiens_hsa030400.80548746
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79879711
58Systemic lupus erythematosus_Homo sapiens_hsa053220.79019759
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78010848
60Selenocompound metabolism_Homo sapiens_hsa004500.76564396
61Sulfur metabolism_Homo sapiens_hsa009200.75385412
62Viral myocarditis_Homo sapiens_hsa054160.74262112
63Olfactory transduction_Homo sapiens_hsa047400.73740607
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72037599
65Fatty acid elongation_Homo sapiens_hsa000620.69557212
66Metabolic pathways_Homo sapiens_hsa011000.68976422
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68953496
68Staphylococcus aureus infection_Homo sapiens_hsa051500.67386763
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66782095
70RNA transport_Homo sapiens_hsa030130.66751354
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66725305
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.62603138
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62262528
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56699360
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.54919366
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54301280
77Regulation of autophagy_Homo sapiens_hsa041400.53506693
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52091915
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51986162
80Leishmaniasis_Homo sapiens_hsa051400.51781224
81Retinol metabolism_Homo sapiens_hsa008300.51416051
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.51317297
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49957407
84Hematopoietic cell lineage_Homo sapiens_hsa046400.47801475
85Fat digestion and absorption_Homo sapiens_hsa049750.46760633
86Salivary secretion_Homo sapiens_hsa049700.39946146
87Collecting duct acid secretion_Homo sapiens_hsa049660.39881654
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.39186755
89Glutathione metabolism_Homo sapiens_hsa004800.38306132
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37769141
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33089080
92Pyruvate metabolism_Homo sapiens_hsa006200.32912201
93Taste transduction_Homo sapiens_hsa047420.32846680
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32110769
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31512650
96Herpes simplex infection_Homo sapiens_hsa051680.30898622
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27876719
98Sulfur relay system_Homo sapiens_hsa041220.26963309
99Nicotine addiction_Homo sapiens_hsa050330.25101713
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23302169

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