SNRNP200

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.68281536
2nuclear pore organization (GO:0006999)6.33096860
3pre-miRNA processing (GO:0031054)4.94123690
4pore complex assembly (GO:0046931)4.89222205
5DNA unwinding involved in DNA replication (GO:0006268)4.85561774
6negative regulation of histone methylation (GO:0031061)4.56872700
7mitotic sister chromatid cohesion (GO:0007064)4.51162211
8protein localization to kinetochore (GO:0034501)4.39573706
9regulation of histone H3-K9 methylation (GO:0051570)4.39539036
10regulation of histone H3-K27 methylation (GO:0061085)4.32798201
11mitotic nuclear envelope disassembly (GO:0007077)4.19863357
12regulation of translational fidelity (GO:0006450)4.19147079
13COPI coating of Golgi vesicle (GO:0048205)4.15718160
14Golgi transport vesicle coating (GO:0048200)4.15718160
15DNA duplex unwinding (GO:0032508)4.07708813
16DNA geometric change (GO:0032392)4.05305178
17nuclear envelope disassembly (GO:0051081)3.99322422
18membrane disassembly (GO:0030397)3.99322422
19regulation of posttranscriptional gene silencing (GO:0060147)3.99315707
20regulation of gene silencing by miRNA (GO:0060964)3.99315707
21regulation of gene silencing by RNA (GO:0060966)3.99315707
22heterochromatin organization (GO:0070828)3.94979004
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.94256474
24dosage compensation (GO:0007549)3.89019792
25sister chromatid segregation (GO:0000819)3.87840440
26regulation of RNA export from nucleus (GO:0046831)3.86428039
27mitotic chromosome condensation (GO:0007076)3.85171370
28folic acid-containing compound biosynthetic process (GO:0009396)3.81322988
29protein-DNA complex disassembly (GO:0032986)3.78890056
30nucleosome disassembly (GO:0006337)3.78890056
31chromatin assembly (GO:0031497)3.69689112
32DNA replication-dependent nucleosome assembly (GO:0006335)3.66023398
33DNA replication-dependent nucleosome organization (GO:0034723)3.66023398
34protein localization to chromosome, centromeric region (GO:0071459)3.56835450
35protein export from nucleus (GO:0006611)3.51644745
36spliceosomal tri-snRNP complex assembly (GO:0000244)3.51605665
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50379372
38IMP biosynthetic process (GO:0006188)3.46933738
39mitotic sister chromatid segregation (GO:0000070)3.45991416
40NLS-bearing protein import into nucleus (GO:0006607)3.44431318
41proline biosynthetic process (GO:0006561)3.43793479
42regulation of sister chromatid cohesion (GO:0007063)3.40882978
43histone H2A monoubiquitination (GO:0035518)3.40850051
44mRNA stabilization (GO:0048255)3.40558561
45RNA stabilization (GO:0043489)3.40558561
46regulation of NFAT protein import into nucleus (GO:0051532)3.39428387
47peptidyl-lysine dimethylation (GO:0018027)3.39231401
48regulation of translational termination (GO:0006449)3.37367435
49DNA strand elongation (GO:0022616)3.37048426
50regulation of mitotic spindle organization (GO:0060236)3.36525013
51negative regulation of DNA repair (GO:0045738)3.31239318
52histone H3-K36 demethylation (GO:0070544)3.30974432
53regulation of spindle organization (GO:0090224)3.24683659
54negative regulation of mRNA processing (GO:0050686)3.23987018
55formation of translation preinitiation complex (GO:0001731)3.23724967
56positive regulation of chromosome segregation (GO:0051984)3.23205862
57cellular response to epidermal growth factor stimulus (GO:0071364)3.22760206
58nuclear envelope organization (GO:0006998)3.20079045
59positive regulation of SMAD protein import into nucleus (GO:0060391)3.18461249
60stress granule assembly (GO:0034063)3.17898936
61DNA conformation change (GO:0071103)3.17012786
62positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.16536482
63positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.16536482
64positive regulation of mitotic sister chromatid separation (GO:1901970)3.16536482
65gene silencing by RNA (GO:0031047)3.14246028
66cytoplasmic mRNA processing body assembly (GO:0033962)3.14207609
67response to epidermal growth factor (GO:0070849)3.13959168
68regulation of DNA endoreduplication (GO:0032875)3.13574362
69regulation of nucleobase-containing compound transport (GO:0032239)3.11875345
70translesion synthesis (GO:0019985)3.11829243
71negative regulation of histone modification (GO:0031057)3.06025020
72glucocorticoid receptor signaling pathway (GO:0042921)3.02164476
73regulation of mammary gland epithelial cell proliferation (GO:0033599)2.99841065
74retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.97526176
75paraxial mesoderm development (GO:0048339)2.95430264
76chromosome condensation (GO:0030261)2.95251817
77gene silencing (GO:0016458)2.94509055
78spindle assembly involved in mitosis (GO:0090307)2.91041941
79DNA replication initiation (GO:0006270)2.90826184
80negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90793198
81negative regulation of chromatin modification (GO:1903309)2.90742732
823-UTR-mediated mRNA stabilization (GO:0070935)2.88604660
83DNA topological change (GO:0006265)2.88583983
84positive regulation of cell cycle checkpoint (GO:1901978)2.87740808
85protein localization to chromosome (GO:0034502)2.87392623
86IMP metabolic process (GO:0046040)2.87295016
87regulation of telomere maintenance via telomerase (GO:0032210)2.87238208
88mRNA transport (GO:0051028)2.85030707
89regulation of histone methylation (GO:0031060)2.85021026
90intracellular estrogen receptor signaling pathway (GO:0030520)2.84383290
91DNA synthesis involved in DNA repair (GO:0000731)2.84226477
92planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83976851
93regulation of gene silencing (GO:0060968)2.83849733
94regulation of DNA damage checkpoint (GO:2000001)2.82932945
95regulation of histone H3-K4 methylation (GO:0051569)2.82625767
96microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.82277037
97determination of adult lifespan (GO:0008340)2.81423079
98regulation of centriole replication (GO:0046599)2.80125749
99regulation of chromatin binding (GO:0035561)2.79717461
100regulation of helicase activity (GO:0051095)2.78963621
101chromatin assembly or disassembly (GO:0006333)2.77999572
102snRNA metabolic process (GO:0016073)2.77869480
103positive regulation of RNA splicing (GO:0033120)2.77797983
104activation of Rac GTPase activity (GO:0032863)2.75191065
105alternative mRNA splicing, via spliceosome (GO:0000380)2.74472521
106V(D)J recombination (GO:0033151)2.73790094
107regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72651147
108positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.71605656
109adherens junction assembly (GO:0034333)2.70968907
110regulation of mRNA stability (GO:0043488)2.70089355
111RNA localization (GO:0006403)2.70063192
112regulation of chromosome segregation (GO:0051983)2.69233255
113regulation of hippo signaling (GO:0035330)2.67880151
114protein complex localization (GO:0031503)2.67560120
115cell-substrate adherens junction assembly (GO:0007045)2.67464684
116focal adhesion assembly (GO:0048041)2.67464684
117positive regulation of DNA-dependent DNA replication (GO:2000105)2.67459717
118peptidyl-arginine N-methylation (GO:0035246)2.66443100
119peptidyl-arginine methylation (GO:0018216)2.66443100
120chromatin silencing (GO:0006342)2.66442229
121regulation of centrosome cycle (GO:0046605)2.66154573
122DNA packaging (GO:0006323)2.65242524
123regulation of protein polyubiquitination (GO:1902914)2.63699709
124regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.61391229
125monoubiquitinated protein deubiquitination (GO:0035520)2.61355548
126histone lysine demethylation (GO:0070076)2.61149662
127protein localization to microtubule (GO:0035372)2.61099039
128RNA transport (GO:0050658)2.60704581
129establishment of RNA localization (GO:0051236)2.60704581
130nucleic acid transport (GO:0050657)2.60704581
131mitotic metaphase plate congression (GO:0007080)2.60476415
132telomere maintenance via semi-conservative replication (GO:0032201)2.60417211
133regulation of SMAD protein import into nucleus (GO:0060390)2.60273326
134peptidyl-arginine omega-N-methylation (GO:0035247)2.59985055
135negative regulation of mRNA metabolic process (GO:1903312)2.59546253
136histone H3-K9 demethylation (GO:0033169)2.59105983
137corticosteroid receptor signaling pathway (GO:0031958)2.58168937
138nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.57906578
139positive regulation of gene expression, epigenetic (GO:0045815)2.57881317
140negative regulation of RNA splicing (GO:0033119)2.57751152
141regulation of centrosome duplication (GO:0010824)2.57627153
142DNA strand elongation involved in DNA replication (GO:0006271)2.56292503
143cellular protein complex localization (GO:0034629)2.56276953
144postreplication repair (GO:0006301)2.55336423
145positive regulation of histone deacetylation (GO:0031065)2.55013722
146cellular hyperosmotic response (GO:0071474)2.54477766
147snRNA processing (GO:0016180)2.54422537
148embryonic process involved in female pregnancy (GO:0060136)2.52977197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.70448754
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.01950961
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73391481
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13066200
5MYC_22102868_ChIP-Seq_BL_Human3.07391202
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.82230592
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71973944
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62762569
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.61871040
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61548744
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.45192498
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21219708
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.16865874
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.14986761
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09278807
16AR_21909140_ChIP-Seq_LNCAP_Human2.00385214
17E2F7_22180533_ChIP-Seq_HELA_Human10.3180450
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85141756
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.80753140
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73659882
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69160538
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68168825
23CIITA_25753668_ChIP-Seq_RAJI_Human1.67714745
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65692973
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64644769
26TCF7_22412390_ChIP-Seq_EML_Mouse1.59740349
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58905710
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58712421
29VDR_21846776_ChIP-Seq_THP-1_Human1.57882652
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57577569
31ZNF263_19887448_ChIP-Seq_K562_Human1.54098783
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51291399
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.50358622
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48472312
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47828260
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47828260
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47828260
38* RACK7_27058665_Chip-Seq_MCF-7_Human1.47790107
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46114281
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45810659
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45484973
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44339717
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42131564
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41338116
45KDM2B_26808549_Chip-Seq_DND41_Human1.40882891
46KDM5A_27292631_Chip-Seq_BREAST_Human1.38952360
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38749453
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37425514
49LXR_22292898_ChIP-Seq_THP-1_Human1.36610520
50XRN2_22483619_ChIP-Seq_HELA_Human1.34640659
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34164167
52TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32599960
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32295772
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31050729
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30315624
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27592102
57CLOCK_20551151_ChIP-Seq_293T_Human1.26224627
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23747225
59NANOG_21062744_ChIP-ChIP_HESCs_Human1.23282871
60KDM2B_26808549_Chip-Seq_K562_Human1.21154800
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21062653
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20760515
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19972210
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18669247
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18620287
66UTX_26944678_Chip-Seq_JUKART_Human1.17734142
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17221003
68TFEB_21752829_ChIP-Seq_HELA_Human1.14402749
69TTF2_22483619_ChIP-Seq_HELA_Human1.13909906
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13416757
71MAF_26560356_Chip-Seq_TH1_Human1.12659346
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11790567
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11585274
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10902348
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10403875
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10323360
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09441095
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07705135
79DCP1A_22483619_ChIP-Seq_HELA_Human1.07422136
80CHD1_26751641_Chip-Seq_LNCaP_Human1.06796687
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06337071
82NCOR1_26117541_ChIP-Seq_K562_Human1.06298144
83TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05662962
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05418302
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04685413
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03649528
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02895618
88FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01232031
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00939813
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.00321117
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00267459
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99028245
93KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97726637
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97595138
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97488143
96RUNX1_27514584_Chip-Seq_MCF-7_Human0.97467437
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96875705
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96869989
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96534964
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96473019
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96171848
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96040933
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95198636
104CREB1_26743006_Chip-Seq_LNCaP_Human0.95048555
105STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94503099
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94414676
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94168570
108GABP_19822575_ChIP-Seq_HepG2_Human0.93611841
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93513169
110MYB_26560356_Chip-Seq_TH1_Human0.93405003
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93289917
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.93076439
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92860000
114POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92446116
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92251867
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92236493
117NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91764789
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90785741
119ATF3_27146783_Chip-Seq_COLON_Human0.90250640
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89764476
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89245718
122SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88505040
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88421488
124MYB_26560356_Chip-Seq_TH2_Human0.88095827
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88077183
126BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87816290
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87529156
128MAF_26560356_Chip-Seq_TH2_Human0.87527104
129ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87344447
130SMC4_20622854_ChIP-Seq_HELA_Human0.86731350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.81128464
2MP0010094_abnormal_chromosome_stability3.33636013
3MP0003705_abnormal_hypodermis_morpholog3.27293069
4MP0005076_abnormal_cell_differentiation3.19253580
5MP0003111_abnormal_nucleus_morphology3.16520867
6MP0010307_abnormal_tumor_latency2.81067558
7MP0003077_abnormal_cell_cycle2.80382947
8MP0002009_preneoplasia2.65547509
9MP0008057_abnormal_DNA_replication2.61605884
10MP0004957_abnormal_blastocyst_morpholog2.54059361
11MP0003693_abnormal_embryo_hatching2.42464003
12MP0001730_embryonic_growth_arrest2.33402696
13MP0000569_abnormal_digit_pigmentation2.18055310
14MP0003123_paternal_imprinting2.17111561
15MP0004197_abnormal_fetal_growth/weight/2.13572043
16MP0000350_abnormal_cell_proliferation2.10929409
17MP0005451_abnormal_body_composition2.10625129
18MP0001672_abnormal_embryogenesis/_devel1.99913247
19MP0005380_embryogenesis_phenotype1.99913247
20MP0010234_abnormal_vibrissa_follicle1.98659681
21MP0002084_abnormal_developmental_patter1.98245028
22MP0000537_abnormal_urethra_morphology1.97534847
23MP0002877_abnormal_melanocyte_morpholog1.91759153
24MP0003984_embryonic_growth_retardation1.90138484
25MP0002088_abnormal_embryonic_growth/wei1.89763492
26MP0002086_abnormal_extraembryonic_tissu1.89482339
27MP0009278_abnormal_bone_marrow1.86243047
28MP0008007_abnormal_cellular_replicative1.84038907
29MP0000566_synostosis1.83819415
30MP0004808_abnormal_hematopoietic_stem1.82960137
31MP0008877_abnormal_DNA_methylation1.80600300
32MP0002085_abnormal_embryonic_tissue1.79425481
33MP0001697_abnormal_embryo_size1.76633832
34MP0003121_genomic_imprinting1.74932606
35MP0000733_abnormal_muscle_development1.69489486
36MP0002396_abnormal_hematopoietic_system1.66861407
37MP0003566_abnormal_cell_adhesion1.65915809
38MP0005409_darkened_coat_color1.64317315
39MP0001849_ear_inflammation1.64252479
40MP0003300_gastrointestinal_ulcer1.62927673
41MP0003567_abnormal_fetal_cardiomyocyte1.57894546
42MP0002080_prenatal_lethality1.57026485
43MP0008058_abnormal_DNA_repair1.55650486
44MP0003890_abnormal_embryonic-extraembry1.54477509
45MP0010030_abnormal_orbit_morphology1.39302086
46MP0008260_abnormal_autophagy1.37793421
47MP0001915_intracranial_hemorrhage1.34326396
48MP0002249_abnormal_larynx_morphology1.33007867
49MP0001348_abnormal_lacrimal_gland1.31997597
50MP0003315_abnormal_perineum_morphology1.30820242
51MP0005623_abnormal_meninges_morphology1.28001266
52MP0009053_abnormal_anal_canal1.27249584
53MP0008932_abnormal_embryonic_tissue1.27095975
54MP0001293_anophthalmia1.26355094
55MP0009703_decreased_birth_body1.24963211
56MP0000428_abnormal_craniofacial_morphol1.24689874
57MP0000371_diluted_coat_color1.24048654
58MP0004185_abnormal_adipocyte_glucose1.24034403
59MP0001346_abnormal_lacrimal_gland1.21518465
60MP0004858_abnormal_nervous_system1.21196623
61MP0003119_abnormal_digestive_system1.18065130
62MP0002925_abnormal_cardiovascular_devel1.17502075
63MP0005187_abnormal_penis_morphology1.17293338
64MP0005023_abnormal_wound_healing1.16764285
65MP0009672_abnormal_birth_weight1.15759833
66MP0002092_abnormal_eye_morphology1.15706505
67MP0003942_abnormal_urinary_system1.14672595
68MP0000678_abnormal_parathyroid_gland1.14009207
69MP0000703_abnormal_thymus_morphology1.13541056
70MP0002697_abnormal_eye_size1.13256432
71MP0004233_abnormal_muscle_weight1.13091357
72MP0004264_abnormal_extraembryonic_tissu1.12468475
73MP0003115_abnormal_respiratory_system1.10155680
74MP0005501_abnormal_skin_physiology1.09142428
75MP0002796_impaired_skin_barrier1.05951078
76MP0008961_abnormal_basal_metabolism1.03798155
77MP0002019_abnormal_tumor_incidence1.02996908
78MP0003385_abnormal_body_wall1.02422898
79MP0000490_abnormal_crypts_of1.02357224
80MP0000313_abnormal_cell_death1.02206063
81MP0003091_abnormal_cell_migration0.99945535
82MP0003453_abnormal_keratinocyte_physiol0.99441713
83MP0001545_abnormal_hematopoietic_system0.98415361
84MP0005397_hematopoietic_system_phenotyp0.98415361
85MP0003935_abnormal_craniofacial_develop0.98182001
86MP0002653_abnormal_ependyma_morphology0.97043742
87MP0003943_abnormal_hepatobiliary_system0.95117552
88MP0003283_abnormal_digestive_organ0.94436488
89MP0002098_abnormal_vibrissa_morphology0.93693966
90MP0003937_abnormal_limbs/digits/tail_de0.93584079
91MP0000377_abnormal_hair_follicle0.91827946
92MP0001661_extended_life_span0.89770427
93MP0010630_abnormal_cardiac_muscle0.89511963
94MP0003787_abnormal_imprinting0.86069496
95MP0000432_abnormal_head_morphology0.84851235
96MP0000266_abnormal_heart_morphology0.84399506
97MP0000003_abnormal_adipose_tissue0.84326822
98MP0008770_decreased_survivor_rate0.84109423
99MP0002111_abnormal_tail_morphology0.84019587
100MP0006054_spinal_hemorrhage0.82417608
101MP0003763_abnormal_thymus_physiology0.81566364
102MP0010678_abnormal_skin_adnexa0.80362373
103MP0003861_abnormal_nervous_system0.79444828
104MP0002075_abnormal_coat/hair_pigmentati0.79021345
105MP0005621_abnormal_cell_physiology0.78398206
106MP0000579_abnormal_nail_morphology0.78025167
107MP0002060_abnormal_skin_morphology0.77888957
108MP0005257_abnormal_intraocular_pressure0.77540517
109MP0000534_abnormal_ureter_morphology0.76639467
110MP0002398_abnormal_bone_marrow0.76431702
111MP0001216_abnormal_epidermal_layer0.75638667
112MP0002166_altered_tumor_susceptibility0.75527922
113MP0005666_abnormal_adipose_tissue0.75135010
114MP0002116_abnormal_craniofacial_bone0.72274966
115MP0003786_premature_aging0.72077252
116MP0002210_abnormal_sex_determination0.70969111
117MP0005384_cellular_phenotype0.70512293
118MP0002722_abnormal_immune_system0.70173239
119MP0001784_abnormal_fluid_regulation0.69751777
120MP0000627_abnormal_mammary_gland0.69674829
121MP0002081_perinatal_lethality0.69231968
122MP0002970_abnormal_white_adipose0.68612624
123MP0001873_stomach_inflammation0.68415930
124MP0001145_abnormal_male_reproductive0.67538096
125MP0000477_abnormal_intestine_morphology0.64103143
126MP0001286_abnormal_eye_development0.63670636
127MP0003045_fibrosis0.62124112
128MP0002089_abnormal_postnatal_growth/wei0.61625646
129MP0000383_abnormal_hair_follicle0.59941706
130MP0005375_adipose_tissue_phenotype0.59923163
131MP0004133_heterotaxia0.59203064

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.06244188
2Abnormality of the astrocytes (HP:0100707)3.50781433
3Astrocytoma (HP:0009592)3.50781433
4Short 4th metacarpal (HP:0010044)3.40096004
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.40096004
6Selective tooth agenesis (HP:0001592)3.10402484
7Asymmetry of the thorax (HP:0001555)3.02394076
8Increased nuchal translucency (HP:0010880)2.98099001
9Volvulus (HP:0002580)2.94872270
10Hyperacusis (HP:0010780)2.93123621
11Medulloblastoma (HP:0002885)2.82076327
12Glioma (HP:0009733)2.81560696
13Deviation of the thumb (HP:0009603)2.81408230
14Proximal placement of thumb (HP:0009623)2.73851209
15Broad face (HP:0000283)2.69659407
16Abnormality of the 4th metacarpal (HP:0010012)2.69134098
17Flat acetabular roof (HP:0003180)2.68108369
18Abnormality of the fingertips (HP:0001211)2.64740577
19Heterotopia (HP:0002282)2.62051787
20Neoplasm of the oral cavity (HP:0100649)2.57168374
21Cerebral aneurysm (HP:0004944)2.56873187
22High anterior hairline (HP:0009890)2.45149949
23Skull defect (HP:0001362)2.44683620
24Abnormality of the distal phalanx of the thumb (HP:0009617)2.40894170
25Colon cancer (HP:0003003)2.38710866
26High pitched voice (HP:0001620)2.36489335
27Basal cell carcinoma (HP:0002671)2.36134536
28Prominent nose (HP:0000448)2.35973766
29Renal duplication (HP:0000075)2.35041161
30Disproportionate tall stature (HP:0001519)2.34819539
31Ankyloglossia (HP:0010296)2.34531296
32Abnormality of the lower motor neuron (HP:0002366)2.33484862
33Renovascular hypertension (HP:0100817)2.33143813
34Overlapping toe (HP:0001845)2.31149898
35Deep palmar crease (HP:0006191)2.30819537
36Long eyelashes (HP:0000527)2.29540665
37Neoplasm of striated muscle (HP:0009728)2.29115803
38Rhabdomyosarcoma (HP:0002859)2.27680580
39Dysmetric saccades (HP:0000641)2.26864486
40Malignant gastrointestinal tract tumors (HP:0006749)2.25598566
41Gastrointestinal carcinoma (HP:0002672)2.25598566
42Pseudobulbar signs (HP:0002200)2.24226691
43Cutaneous melanoma (HP:0012056)2.23426073
44Subacute progressive viral hepatitis (HP:0006572)2.23118185
45Abnormal number of incisors (HP:0011064)2.22920053
46Trigonocephaly (HP:0000243)2.22813989
4711 pairs of ribs (HP:0000878)2.22423293
48Macroorchidism (HP:0000053)2.21361198
49Shallow orbits (HP:0000586)2.18556336
50Elfin facies (HP:0004428)2.16485270
51Biliary tract neoplasm (HP:0100574)2.15374674
52Long palpebral fissure (HP:0000637)2.15029067
53Metaphyseal cupping (HP:0003021)2.12544000
54Dislocated radial head (HP:0003083)2.10562443
55Patellar dislocation (HP:0002999)2.09227724
56Abnormality of the labia minora (HP:0012880)2.06480880
57Missing ribs (HP:0000921)2.02963700
58Vertebral arch anomaly (HP:0008438)2.02827261
59Truncal obesity (HP:0001956)2.01532069
60Bowel diverticulosis (HP:0005222)2.00973130
61Cutis marmorata (HP:0000965)2.00141314
62Sandal gap (HP:0001852)1.99359820
63Limited elbow extension (HP:0001377)1.99007677
64Reticulocytosis (HP:0001923)1.98461127
65Urethral obstruction (HP:0000796)1.97508586
66Supernumerary ribs (HP:0005815)1.97456141
67Cafe-au-lait spot (HP:0000957)1.96822140
68Abnormality of the radial head (HP:0003995)1.96688395
69Ulnar bowing (HP:0003031)1.95231627
70Amaurosis fugax (HP:0100576)1.94849787
71Increased density of long bones (HP:0006392)1.94557022
72Obsessive-compulsive behavior (HP:0000722)1.94359248
73Hand muscle atrophy (HP:0009130)1.92905592
74Deep philtrum (HP:0002002)1.92151550
75Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90264860
76Insidious onset (HP:0003587)1.89637239
77Termporal pattern (HP:0011008)1.89637239
78Fibrous tissue neoplasm (HP:0012316)1.88640264
79Skin tags (HP:0010609)1.88167149
80Fibroma (HP:0010614)1.86934646
81Overriding aorta (HP:0002623)1.86015238
82Ankle contracture (HP:0006466)1.85684342
83Broad palm (HP:0001169)1.85653683
84Sparse lateral eyebrow (HP:0005338)1.84676023
85Abnormal foot bone ossification (HP:0010675)1.83345197
86Absent frontal sinuses (HP:0002688)1.83277076
87Pointed chin (HP:0000307)1.83074486
88Spastic diplegia (HP:0001264)1.82480975
89Broad thumb (HP:0011304)1.81822892
90Abnormality of chromosome segregation (HP:0002916)1.81710194
91Abnormal gallbladder physiology (HP:0012438)1.80878086
92Cholecystitis (HP:0001082)1.80878086
93Abnormality of chromosome stability (HP:0003220)1.80065438
94Ectopic kidney (HP:0000086)1.78690275
95Low anterior hairline (HP:0000294)1.78586195
96Spinal cord lesions (HP:0100561)1.78060099
97Syringomyelia (HP:0003396)1.78060099
98Advanced eruption of teeth (HP:0006288)1.77992529
99Bowel incontinence (HP:0002607)1.77467054
100Chromsome breakage (HP:0040012)1.76922323
101Agnosia (HP:0010524)1.75791183
102Broad distal phalanx of finger (HP:0009836)1.74830948
103Thin ribs (HP:0000883)1.74411855
104Arnold-Chiari malformation (HP:0002308)1.72882161
105Septate vagina (HP:0001153)1.72214811
106Esophageal atresia (HP:0002032)1.71707916
107Relative macrocephaly (HP:0004482)1.71623837
108Abnormality of the peritoneum (HP:0002585)1.71133325
109Progressive external ophthalmoplegia (HP:0000590)1.70557718
110Spina bifida occulta (HP:0003298)1.69994485
111Abnormality of the phalanges of the hallux (HP:0010057)1.69322024
112Attention deficit hyperactivity disorder (HP:0007018)1.68428475
113Distal upper limb amyotrophy (HP:0007149)1.67198347
114Upper limb amyotrophy (HP:0009129)1.67198347
115Abnormality of the diencephalon (HP:0010662)1.67118271
116Cortical dysplasia (HP:0002539)1.66901428
117Supernumerary bones of the axial skeleton (HP:0009144)1.66409079
118Insomnia (HP:0100785)1.65932325
119Anal stenosis (HP:0002025)1.65798223
120Facial hemangioma (HP:0000329)1.65279540
121Narrow palate (HP:0000189)1.64117743
122Impulsivity (HP:0100710)1.62254752
123Abnormality of cochlea (HP:0000375)1.62162709
124Nephroblastoma (Wilms tumor) (HP:0002667)1.62101044
125Bicuspid aortic valve (HP:0001647)1.61561572
126Flat cornea (HP:0007720)1.61476124
127Precocious puberty (HP:0000826)1.60761614
128Atresia of the external auditory canal (HP:0000413)1.60725649
129Abnormal large intestine physiology (HP:0012700)1.59758994
130Uterine leiomyosarcoma (HP:0002891)1.59659261
131Leiomyosarcoma (HP:0100243)1.59659261
132Intestinal polyp (HP:0005266)1.59334875
133Preauricular skin tag (HP:0000384)1.59244513
134Short humerus (HP:0005792)1.59100410
135Megalocornea (HP:0000485)1.58269013
136Germ cell neoplasia (HP:0100728)1.57941800
137Back pain (HP:0003418)1.57710851
138Abnormality of oral frenula (HP:0000190)1.57616940
139Angiofibromas (HP:0010615)1.57314408
140Adenoma sebaceum (HP:0009720)1.57314408
141Abnormality of reticulocytes (HP:0004312)1.57053608
142Smooth philtrum (HP:0000319)1.56484933
143Abnormality of the thoracic spine (HP:0100711)1.55934494
144Aneurysm (HP:0002617)1.55721195
145Large earlobe (HP:0009748)1.55693603
146Obstructive sleep apnea (HP:0002870)1.55693602
147Abnormality of the carotid arteries (HP:0005344)1.55638567
148Abnormality of the humeroradial joint (HP:0100744)1.55607584
149Rectal prolapse (HP:0002035)1.55009238
150Abnormality of the calcaneus (HP:0008364)1.54449298
151Pelvic girdle muscle weakness (HP:0003749)1.54390685
152Microvesicular hepatic steatosis (HP:0001414)1.54275071
153Biconcave vertebral bodies (HP:0004586)1.53839561
154Chromosomal breakage induced by crosslinking agents (HP:0003221)1.53695554
155Broad phalanges of the hand (HP:0009768)1.53149504
156Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51835573
157Premature skin wrinkling (HP:0100678)1.51267826
158Abnormality of the salivary glands (HP:0010286)1.50955959

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.90471352
2SMG13.82473694
3CDC73.71691138
4EEF2K3.71444677
5PKN22.94572747
6MAP3K102.88602122
7TRIB32.55360151
8NEK22.53654162
9BRD42.29369529
10PASK2.09358390
11PRPF4B2.07000955
12TTK2.05577579
13TTN1.93022604
14RPS6KB21.71646937
15SCYL21.68686901
16RIPK11.60314379
17ALK1.59523372
18CDK41.58203611
19PTK61.53625925
20STK101.53293950
21ATR1.52633297
22NEK11.52354712
23TSSK61.51730699
24CDK61.49719978
25MTOR1.49647860
26CAMK1D1.49481452
27WEE11.48649384
28PDGFRA1.40454863
29IRAK31.39260314
30LATS11.34484125
31ICK1.30501449
32EIF2AK11.30290795
33EPHA21.29997171
34CHEK11.29124889
35STK31.18349321
36MAP3K81.15697065
37CAMK1G1.13153128
38KSR21.10679761
39SIK11.09334322
40FGFR31.08999878
41MST1R1.08389014
42CDK71.07699344
43TGFBR11.05640159
44PAK41.05356430
45STK41.01698586
46PLK11.01044033
47FGFR11.00498881
48ATM1.00010905
49AURKB0.96950668
50FLT30.94113693
51BMX0.91923987
52CDK20.90642967
53MAP4K10.90548273
54LRRK20.90064749
55FGFR40.89704210
56CDK90.89203696
57SIK20.88471391
58CHEK20.86715710
59PAK20.84785030
60MELK0.82567968
61MAP2K30.82312508
62ERN10.82240468
63PDGFRB0.80859761
64MAPK110.78868449
65CDK80.77279489
66CSNK1D0.77244006
67PLK30.76178892
68PIM10.74264045
69FGFR20.73365408
70PBK0.72339819
71MKNK10.70945852
72CLK10.70938848
73TYRO30.69538537
74SRPK10.68922006
75PNCK0.68742028
76JAK30.68573091
77RPS6KA40.67784813
78BRSK10.66330003
79CDK10.66192577
80BUB10.65937873
81MARK20.60184475
82PRKDC0.59502753
83YES10.58828787
84SIK30.57815015
85MAP2K20.56075717
86NTRK10.55541180
87GRK60.53868034
88RET0.53190044
89PRKD30.53157128
90MAPK140.50643182
91AKT20.50531896
92MAP3K130.50210284
93CHUK0.50068325
94CSNK1E0.49997702
95KSR10.47879792
96MAP3K140.47718925
97MET0.47193608
98SGK30.46683551
99MARK30.46538657
100TAF10.45520757
101NEK60.44956281
102CDC42BPA0.44686850
103ZAP700.43275025
104MAPK10.42122089
105AKT10.41195144
106RPS6KB10.40118191
107PTK20.39316040
108MAP3K70.38951022
109GSK3B0.38882485
110TESK20.38622846
111PLK40.38609216
112DMPK0.38500598
113TLK10.38351859
114WNK10.38274798
115RAF10.37847025
116RPS6KA10.37679893
117MKNK20.37604531
118BRSK20.37517746
119RPS6KA20.36923799
120RPS6KC10.36704991
121RPS6KL10.36704991
122BRAF0.35971169
123EGFR0.35029846
124CSF1R0.34349696
125ITK0.33398200
126MAPK100.32442960
127LATS20.31992736
128CSNK2A20.31812176
129JAK10.30988649

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.72320493
2One carbon pool by folate_Homo sapiens_hsa006702.69048779
3Mismatch repair_Homo sapiens_hsa034302.52294424
4RNA transport_Homo sapiens_hsa030132.48448755
5Cell cycle_Homo sapiens_hsa041102.29565010
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20146120
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15476318
8mRNA surveillance pathway_Homo sapiens_hsa030152.13733362
9* Spliceosome_Homo sapiens_hsa030402.08829291
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.04336329
11Systemic lupus erythematosus_Homo sapiens_hsa053221.77056305
12Lysine degradation_Homo sapiens_hsa003101.70793038
13MicroRNAs in cancer_Homo sapiens_hsa052061.66851188
14Base excision repair_Homo sapiens_hsa034101.66831223
15Viral carcinogenesis_Homo sapiens_hsa052031.63646956
16Chronic myeloid leukemia_Homo sapiens_hsa052201.63323267
17Small cell lung cancer_Homo sapiens_hsa052221.55554579
18mTOR signaling pathway_Homo sapiens_hsa041501.53579996
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51697572
20Adherens junction_Homo sapiens_hsa045201.49200242
21Nucleotide excision repair_Homo sapiens_hsa034201.37687262
22Non-homologous end-joining_Homo sapiens_hsa034501.33818610
23HTLV-I infection_Homo sapiens_hsa051661.33328403
24Notch signaling pathway_Homo sapiens_hsa043301.31905207
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31420421
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.31266298
27Pentose phosphate pathway_Homo sapiens_hsa000301.31122525
28ErbB signaling pathway_Homo sapiens_hsa040121.29720759
29Fanconi anemia pathway_Homo sapiens_hsa034601.27826067
30Colorectal cancer_Homo sapiens_hsa052101.27354706
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25403907
32Antigen processing and presentation_Homo sapiens_hsa046121.24636213
33p53 signaling pathway_Homo sapiens_hsa041151.24579906
34Selenocompound metabolism_Homo sapiens_hsa004501.22521456
35Viral myocarditis_Homo sapiens_hsa054161.22242600
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19517359
37Homologous recombination_Homo sapiens_hsa034401.17460128
38Basal cell carcinoma_Homo sapiens_hsa052171.17399342
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16131430
40Proteoglycans in cancer_Homo sapiens_hsa052051.15261416
41Hippo signaling pathway_Homo sapiens_hsa043901.15139616
42Non-small cell lung cancer_Homo sapiens_hsa052231.13728072
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10100013
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06519401
45Endometrial cancer_Homo sapiens_hsa052131.03867470
46RNA degradation_Homo sapiens_hsa030181.00369437
47Nitrogen metabolism_Homo sapiens_hsa009100.96731347
48Carbon metabolism_Homo sapiens_hsa012000.96173854
49Oocyte meiosis_Homo sapiens_hsa041140.95491853
50Herpes simplex infection_Homo sapiens_hsa051680.95104909
51Fructose and mannose metabolism_Homo sapiens_hsa000510.93490952
52Choline metabolism in cancer_Homo sapiens_hsa052310.92984574
53Dorso-ventral axis formation_Homo sapiens_hsa043200.90975387
54Epstein-Barr virus infection_Homo sapiens_hsa051690.90851223
55Inositol phosphate metabolism_Homo sapiens_hsa005620.90831087
56Focal adhesion_Homo sapiens_hsa045100.89435027
57Acute myeloid leukemia_Homo sapiens_hsa052210.87862746
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86644162
59Pancreatic cancer_Homo sapiens_hsa052120.86372080
60Prostate cancer_Homo sapiens_hsa052150.86342596
61Thyroid cancer_Homo sapiens_hsa052160.86229638
62TGF-beta signaling pathway_Homo sapiens_hsa043500.84502199
63HIF-1 signaling pathway_Homo sapiens_hsa040660.84482468
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.84192302
65Biosynthesis of amino acids_Homo sapiens_hsa012300.83871460
66B cell receptor signaling pathway_Homo sapiens_hsa046620.82282450
67Prion diseases_Homo sapiens_hsa050200.82033844
68Other glycan degradation_Homo sapiens_hsa005110.80608382
69Hepatitis B_Homo sapiens_hsa051610.79952812
70Insulin resistance_Homo sapiens_hsa049310.79612879
71Alcoholism_Homo sapiens_hsa050340.78515193
72Pathways in cancer_Homo sapiens_hsa052000.77997426
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77557088
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77495282
75Toxoplasmosis_Homo sapiens_hsa051450.77239695
76Glioma_Homo sapiens_hsa052140.75568934
77T cell receptor signaling pathway_Homo sapiens_hsa046600.73425831
78Apoptosis_Homo sapiens_hsa042100.72458786
79Bladder cancer_Homo sapiens_hsa052190.72047768
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.71853828
81AMPK signaling pathway_Homo sapiens_hsa041520.69793474
82FoxO signaling pathway_Homo sapiens_hsa040680.66423785
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66311528
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66230819
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.65634395
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63716164
87Fatty acid biosynthesis_Homo sapiens_hsa000610.63587644
88Tight junction_Homo sapiens_hsa045300.63264535
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62972194
90Hedgehog signaling pathway_Homo sapiens_hsa043400.62965970
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62963201
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62915102
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62196055
94Hepatitis C_Homo sapiens_hsa051600.61911949
95N-Glycan biosynthesis_Homo sapiens_hsa005100.61697631
96VEGF signaling pathway_Homo sapiens_hsa043700.61091941
97Insulin signaling pathway_Homo sapiens_hsa049100.60466990
98Primary immunodeficiency_Homo sapiens_hsa053400.60264967
99Type II diabetes mellitus_Homo sapiens_hsa049300.59224116
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.57805730
101Renal cell carcinoma_Homo sapiens_hsa052110.56928623
102Glucagon signaling pathway_Homo sapiens_hsa049220.56870041
103Measles_Homo sapiens_hsa051620.55992402
104Estrogen signaling pathway_Homo sapiens_hsa049150.54691157
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53920024
106Prolactin signaling pathway_Homo sapiens_hsa049170.53457994
107Wnt signaling pathway_Homo sapiens_hsa043100.52823781
108ECM-receptor interaction_Homo sapiens_hsa045120.51566663
109Melanoma_Homo sapiens_hsa052180.51253082
110Legionellosis_Homo sapiens_hsa051340.50485790
111Melanogenesis_Homo sapiens_hsa049160.49926934
112Thyroid hormone synthesis_Homo sapiens_hsa049180.48782003
113Osteoclast differentiation_Homo sapiens_hsa043800.48487748
114Influenza A_Homo sapiens_hsa051640.47658179
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47534651
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47152224
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.47126553
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45921048
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44233500
120Steroid biosynthesis_Homo sapiens_hsa001000.43886249
121Amoebiasis_Homo sapiens_hsa051460.42742775
122GnRH signaling pathway_Homo sapiens_hsa049120.41898623

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