SNF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.20995924
2translational termination (GO:0006415)5.97051455
3regulation of nuclear cell cycle DNA replication (GO:0033262)5.49011574
4DNA deamination (GO:0045006)5.42858138
5translational elongation (GO:0006414)5.32998985
6ribosome assembly (GO:0042255)5.24482884
7DNA replication checkpoint (GO:0000076)5.16220718
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.91404586
9ribosome biogenesis (GO:0042254)4.87197900
10rRNA modification (GO:0000154)4.86147359
11protein targeting to ER (GO:0045047)4.84687734
12cotranslational protein targeting to membrane (GO:0006613)4.79188031
13viral life cycle (GO:0019058)4.77134946
14GDP-mannose metabolic process (GO:0019673)4.74457010
15ribosomal small subunit assembly (GO:0000028)4.72901004
16proteasome assembly (GO:0043248)4.61968728
17protein localization to endoplasmic reticulum (GO:0070972)4.61791966
18regulation of mitochondrial translation (GO:0070129)4.60962577
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.60696944
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.57403431
21cellular protein complex disassembly (GO:0043624)4.55787808
22chaperone-mediated protein transport (GO:0072321)4.54754471
23DNA replication initiation (GO:0006270)4.49749736
24telomere maintenance via semi-conservative replication (GO:0032201)4.45632666
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.40691321
26DNA strand elongation involved in DNA replication (GO:0006271)4.30603172
27ATP synthesis coupled proton transport (GO:0015986)4.30360668
28energy coupled proton transport, down electrochemical gradient (GO:0015985)4.30360668
29ribonucleoprotein complex biogenesis (GO:0022613)4.29468533
30mitochondrial DNA replication (GO:0006264)4.27574184
31translational initiation (GO:0006413)4.22896464
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.21785174
33histone H4-K12 acetylation (GO:0043983)4.20643035
34formation of translation preinitiation complex (GO:0001731)4.13788479
35DNA strand elongation (GO:0022616)4.07510575
36purine nucleobase biosynthetic process (GO:0009113)4.02069763
37nucleobase biosynthetic process (GO:0046112)4.00336162
38protein complex biogenesis (GO:0070271)3.99607513
39protein complex disassembly (GO:0043241)3.99084065
40mitotic metaphase plate congression (GO:0007080)3.96018636
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.95273599
42NADH dehydrogenase complex assembly (GO:0010257)3.95273599
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.95273599
44mitochondrial respiratory chain complex assembly (GO:0033108)3.94475987
45translation (GO:0006412)3.92846408
46ribosomal small subunit biogenesis (GO:0042274)3.91999736
47telomere maintenance via recombination (GO:0000722)3.89912606
48pseudouridine synthesis (GO:0001522)3.89165182
49rRNA methylation (GO:0031167)3.87132781
50ncRNA 3-end processing (GO:0043628)3.82665828
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.81653387
52termination of RNA polymerase III transcription (GO:0006386)3.81653387
53DNA damage response, detection of DNA damage (GO:0042769)3.81343965
54protein localization to kinetochore (GO:0034501)3.80737912
55maturation of SSU-rRNA (GO:0030490)3.79685200
56regulation of double-strand break repair via homologous recombination (GO:0010569)3.79041898
57behavioral response to nicotine (GO:0035095)3.78483917
58tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.77660476
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.77660476
60macromolecular complex disassembly (GO:0032984)3.75596270
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.75244628
62respiratory electron transport chain (GO:0022904)3.70947509
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70202736
64regulation of telomere maintenance via telomerase (GO:0032210)3.68714228
65DNA-dependent DNA replication (GO:0006261)3.68557397
66electron transport chain (GO:0022900)3.68046940
67telomere maintenance via telomere lengthening (GO:0010833)3.67946427
68DNA replication-dependent nucleosome organization (GO:0034723)3.65529987
69DNA replication-dependent nucleosome assembly (GO:0006335)3.65529987
70protein targeting to mitochondrion (GO:0006626)3.65462941
71tRNA modification (GO:0006400)3.63957851
72mitotic recombination (GO:0006312)3.63553332
73peptidyl-histidine modification (GO:0018202)3.61724863
74deoxyribonucleotide biosynthetic process (GO:0009263)3.61520560
75establishment of protein localization to mitochondrion (GO:0072655)3.60145042
76UTP biosynthetic process (GO:0006228)3.52446164
77ribosomal large subunit biogenesis (GO:0042273)3.51291771
78spliceosomal snRNP assembly (GO:0000387)3.50302336
79GTP biosynthetic process (GO:0006183)3.50196715
80rRNA processing (GO:0006364)3.48782334
81maturation of 5.8S rRNA (GO:0000460)3.47089161
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44710211
83transcription from RNA polymerase I promoter (GO:0006360)3.44347472
84protein-cofactor linkage (GO:0018065)3.43085444
85mitochondrial DNA metabolic process (GO:0032042)3.42186260
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.42099900
87rRNA metabolic process (GO:0016072)3.37977319
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36548942
89protein targeting to membrane (GO:0006612)3.35523517
90folic acid metabolic process (GO:0046655)3.31556609
91nucleobase-containing small molecule interconversion (GO:0015949)3.29715483
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29665734
93guanosine-containing compound biosynthetic process (GO:1901070)3.29045325
94protein localization to mitochondrion (GO:0070585)3.28910516
95cellular component biogenesis (GO:0044085)3.27910178
967-methylguanosine mRNA capping (GO:0006370)3.26994310
97cytochrome complex assembly (GO:0017004)3.26801271
98deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.26478826
99regulation of centriole replication (GO:0046599)3.26170430
100ncRNA processing (GO:0034470)3.25325134
101transcription-coupled nucleotide-excision repair (GO:0006283)3.24549536
102base-excision repair, AP site formation (GO:0006285)3.24400913
103spliceosomal complex assembly (GO:0000245)3.24241961
104cullin deneddylation (GO:0010388)3.23958138
105signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22838279
106signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22838279
107signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22838279
108mitochondrial RNA metabolic process (GO:0000959)3.22517811
109metaphase plate congression (GO:0051310)3.22355235
110regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22219807
111CENP-A containing nucleosome assembly (GO:0034080)3.21086378
112chromatin remodeling at centromere (GO:0031055)3.20613475
113histone H4-K5 acetylation (GO:0043981)3.20122408
114histone H4-K8 acetylation (GO:0043982)3.20122408
115protein localization to chromosome, centromeric region (GO:0071459)3.19982986
116signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19907426
117signal transduction involved in DNA damage checkpoint (GO:0072422)3.19907426
118negative regulation of telomerase activity (GO:0051974)3.19455961
119mitotic sister chromatid segregation (GO:0000070)3.19260677
1207-methylguanosine RNA capping (GO:0009452)3.17342614
121RNA capping (GO:0036260)3.17342614
122signal transduction involved in cell cycle checkpoint (GO:0072395)3.16361276
123regulation of translation in response to stress (GO:0043555)3.15838418
124tRNA processing (GO:0008033)3.14468133
125IMP biosynthetic process (GO:0006188)3.13743641
126RNA methylation (GO:0001510)3.13224276
127UTP metabolic process (GO:0046051)3.13153880
128deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12592765
129negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.12444122
130negative regulation of telomere maintenance (GO:0032205)3.12329092
131respiratory chain complex IV assembly (GO:0008535)3.10745549
132nuclear-transcribed mRNA catabolic process (GO:0000956)3.10286051
133negative regulation of ligase activity (GO:0051352)3.10283573
134negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10283573
135folic acid-containing compound biosynthetic process (GO:0009396)3.09521233
136receptor recycling (GO:0001881)3.09152792
137pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.08083187
138DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08023781
139mitotic nuclear envelope disassembly (GO:0007077)3.07277168
140protein deneddylation (GO:0000338)3.06094867
141deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.05256418
142regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.04793850
143DNA replication (GO:0006260)3.04481130
144rRNA transcription (GO:0009303)3.04157347
145protein insertion into membrane (GO:0051205)3.03756396
146L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.03703148
147intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02914152
148signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02914152
149DNA unwinding involved in DNA replication (GO:0006268)3.02797093
150kinetochore assembly (GO:0051382)3.01874705
151exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01681781
152negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.00493712
153nucleotide-excision repair, DNA gap filling (GO:0006297)3.00248115
154transcription from mitochondrial promoter (GO:0006390)2.99815328
155mRNA catabolic process (GO:0006402)2.99298399
156nuclear pore organization (GO:0006999)2.98010058
157negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97560524
158negative regulation of sister chromatid segregation (GO:0033046)2.97560524
159negative regulation of mitotic sister chromatid separation (GO:2000816)2.97560524
160negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97560524
161pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.97304450
162RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.96875585
163UV protection (GO:0009650)2.96725415
164negative regulation of chromosome segregation (GO:0051985)2.95705755
165pyrimidine nucleotide catabolic process (GO:0006244)2.94923987
166attachment of spindle microtubules to kinetochore (GO:0008608)2.94862987
167positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94111381
168pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.92669745
169protein neddylation (GO:0045116)2.91726211
170pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.89777402
171CTP biosynthetic process (GO:0006241)2.87565639
172CTP metabolic process (GO:0046036)2.87565639
173regulation of translational fidelity (GO:0006450)2.84172254
174purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.83823392
175mitochondrion morphogenesis (GO:0070584)2.81993071
176purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80665947
177tRNA methylation (GO:0030488)2.80395170
178pteridine-containing compound biosynthetic process (GO:0042559)2.79760289
179RNA catabolic process (GO:0006401)2.76730975
180ncRNA metabolic process (GO:0034660)2.76424284
181metallo-sulfur cluster assembly (GO:0031163)2.75726825
182iron-sulfur cluster assembly (GO:0016226)2.75726825
183mitochondrial transport (GO:0006839)2.73702293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.46769187
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.13408640
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68894911
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35105849
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27044628
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.24922748
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.24057096
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.19512339
9* GABP_17652178_ChIP-ChIP_JURKAT_Human3.15566661
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.12856516
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04492951
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.94473108
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93698927
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89981017
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84659639
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74513452
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49021827
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.47903155
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.47903155
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.47903155
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44208700
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32620098
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30876513
24VDR_23849224_ChIP-Seq_CD4+_Human2.24239355
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18155660
26VDR_21846776_ChIP-Seq_THP-1_Human2.17632403
27NANOG_18555785_ChIP-Seq_MESCs_Mouse2.17490183
28* XRN2_22483619_ChIP-Seq_HELA_Human2.16553102
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.11903352
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08459778
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08119586
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04474194
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03890376
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01895815
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.99981026
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94813025
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94777379
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.92294219
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89944198
40FOXP3_21729870_ChIP-Seq_TREG_Human1.87675819
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86717557
42P68_20966046_ChIP-Seq_HELA_Human1.85109427
43ZNF263_19887448_ChIP-Seq_K562_Human1.84459480
44LXR_22292898_ChIP-Seq_THP-1_Human1.82707056
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82117622
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.81077860
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78789280
48* GABP_19822575_ChIP-Seq_HepG2_Human1.77591308
49DCP1A_22483619_ChIP-Seq_HELA_Human1.73898766
50TTF2_22483619_ChIP-Seq_HELA_Human1.72590576
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69361236
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68027872
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66246973
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65851255
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62940777
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61502067
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55167352
58AR_21909140_ChIP-Seq_LNCAP_Human1.53219744
59FOXP1_21924763_ChIP-Seq_HESCs_Human1.51906713
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50964396
61ELK1_19687146_ChIP-ChIP_HELA_Human1.49849445
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49311956
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.49252431
64CIITA_25753668_ChIP-Seq_RAJI_Human1.49107109
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47156982
66RACK7_27058665_Chip-Seq_MCF-7_Human1.45804619
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45554787
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.43705966
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43568080
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.42585530
71BCL6_27268052_Chip-Seq_Bcells_Human1.38963389
72PHF8_20622854_ChIP-Seq_HELA_Human1.38386158
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37392423
74* TP63_19390658_ChIP-ChIP_HaCaT_Human1.33915337
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33642074
76BCOR_27268052_Chip-Seq_Bcells_Human1.33536567
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32937810
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.32405578
79KDM5A_27292631_Chip-Seq_BREAST_Human1.31275550
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.31231194
81NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.30750658
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.30209131
83* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30189061
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29509907
85E2F1_20622854_ChIP-Seq_HELA_Human1.28851575
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25047258
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.24609868
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24431052
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.24299306
90* CTCF_26484167_Chip-Seq_Bcells_Mouse1.22143604
91CTCF_20526341_ChIP-Seq_ESCs_Human1.20082872
92TP53_22127205_ChIP-Seq_IMR90_Human1.19958857
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18937486
94RARA_24833708_ChIP-Seq_LIVER_Mouse1.18685409
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.18447568
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17966102
97MYC_22102868_ChIP-Seq_BL_Human1.17232974
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16021455
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15610683
100TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14629672
101SMC4_20622854_ChIP-Seq_HELA_Human1.13101008
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12719151
103CTCF_21964334_Chip-Seq_Bcells_Human1.12499313
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11878193
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11858229
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11568280
107RARB_24833708_ChIP-Seq_LIVER_Mouse1.11396343
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10872092
109HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10589454
110BP1_19119308_ChIP-ChIP_Hs578T_Human1.09738565
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09647985
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.09139659
113* MAF_26560356_Chip-Seq_TH2_Human1.09123350
114EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08973549
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08900012
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07949214
117* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07791628
118CTCF_27219007_Chip-Seq_Bcells_Human1.07759797
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07488519
120MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06930536
121OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05909587
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05704113
123PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04668644
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04039059
125ATF3_27146783_Chip-Seq_COLON_Human1.03885300
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03752938
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03516150
128SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03297977
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03232295
130RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03028775
131SA1_27219007_Chip-Seq_Bcells_Human1.02873941
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02314741
133TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01045020
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95583021
135POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93622554
136SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89418602
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88085948
138ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87694703
139SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87543028
140TFEB_21752829_ChIP-Seq_HELA_Human0.87403727
141YY1_22570637_ChIP-Seq_MALME-3M_Human0.86312025
142NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85854391
143NANOG_16153702_ChIP-ChIP_HESCs_Human0.85008843
144SOX2_18692474_ChIP-Seq_MESCs_Mouse0.82096572
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81387852
146ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81109240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.37819989
2MP0003111_abnormal_nucleus_morphology4.65261951
3MP0008057_abnormal_DNA_replication4.28880797
4MP0004957_abnormal_blastocyst_morpholog4.27750709
5MP0010094_abnormal_chromosome_stability3.89712025
6MP0003077_abnormal_cell_cycle3.84388634
7MP0008058_abnormal_DNA_repair3.66011085
8MP0009379_abnormal_foot_pigmentation3.61162999
9MP0003136_yellow_coat_color3.26867399
10MP0002837_dystrophic_cardiac_calcinosis2.93136201
11MP0008007_abnormal_cellular_replicative2.82292224
12MP0006292_abnormal_olfactory_placode2.77761943
13MP0008877_abnormal_DNA_methylation2.73842693
14MP0003718_maternal_effect2.64044954
15MP0008932_abnormal_embryonic_tissue2.63297610
16MP0005058_abnormal_lysosome_morphology2.61717029
17MP0003786_premature_aging2.50843057
18MP0001986_abnormal_taste_sensitivity2.37234525
19MP0003890_abnormal_embryonic-extraembry2.17556976
20MP0005174_abnormal_tail_pigmentation2.10834352
21MP0010352_gastrointestinal_tract_polyps2.08242101
22MP0003123_paternal_imprinting2.07477561
23MP0002160_abnormal_reproductive_system2.07181812
24MP0003806_abnormal_nucleotide_metabolis2.07069598
25MP0008875_abnormal_xenobiotic_pharmacok2.02958226
26MP0000350_abnormal_cell_proliferation2.01585143
27MP0001730_embryonic_growth_arrest1.99937815
28MP0006035_abnormal_mitochondrial_morpho1.94855951
29MP0004185_abnormal_adipocyte_glucose1.94796257
30MP0005423_abnormal_somatic_nervous1.89758318
31MP0004233_abnormal_muscle_weight1.84385743
32MP0002277_abnormal_respiratory_mucosa1.80580223
33MP0002139_abnormal_hepatobiliary_system1.80157220
34MP0001672_abnormal_embryogenesis/_devel1.80098680
35MP0005380_embryogenesis_phenotype1.80098680
36MP0003315_abnormal_perineum_morphology1.79730082
37MP0000015_abnormal_ear_pigmentation1.78677597
38MP0005171_absent_coat_pigmentation1.78457354
39MP0005451_abnormal_body_composition1.75783878
40MP0004133_heterotaxia1.75013304
41MP0005075_abnormal_melanosome_morpholog1.71832684
42MP0001853_heart_inflammation1.70458426
43MP0003646_muscle_fatigue1.68756881
44MP0005389_reproductive_system_phenotype1.68618979
45MP0002736_abnormal_nociception_after1.66334891
46MP0002938_white_spotting1.62986617
47MP0000313_abnormal_cell_death1.60493002
48MP0003186_abnormal_redox_activity1.59450774
49MP0002210_abnormal_sex_determination1.54117280
50MP0000049_abnormal_middle_ear1.52155367
51MP0003984_embryonic_growth_retardation1.51223133
52MP0002163_abnormal_gland_morphology1.50752925
53MP0002088_abnormal_embryonic_growth/wei1.49227083
54MP0003941_abnormal_skin_development1.45713827
55MP0001905_abnormal_dopamine_level1.45395561
56MP0001145_abnormal_male_reproductive1.44335387
57MP0002396_abnormal_hematopoietic_system1.43323407
58MP0001697_abnormal_embryo_size1.41518510
59MP0004858_abnormal_nervous_system1.41280886
60MP0005083_abnormal_biliary_tract1.38128426
61MP0004264_abnormal_extraembryonic_tissu1.37221223
62MP0003705_abnormal_hypodermis_morpholog1.36203640
63MP0002085_abnormal_embryonic_tissue1.35861084
64MP0005332_abnormal_amino_acid1.34915670
65MP0002080_prenatal_lethality1.34691315
66MP0001188_hyperpigmentation1.33138640
67MP0001968_abnormal_touch/_nociception1.31870157
68MP0005394_taste/olfaction_phenotype1.30587697
69MP0005499_abnormal_olfactory_system1.30587697
70MP0009053_abnormal_anal_canal1.28840419
71MP0001346_abnormal_lacrimal_gland1.25336792
72MP0002019_abnormal_tumor_incidence1.23679359
73MP0003011_delayed_dark_adaptation1.23533804
74MP0001873_stomach_inflammation1.23238734
75MP0000537_abnormal_urethra_morphology1.21369972
76MP0002877_abnormal_melanocyte_morpholog1.21252586
77MP0000490_abnormal_crypts_of1.20825447
78MP0000358_abnormal_cell_content/1.19284854
79MP0005501_abnormal_skin_physiology1.16585576
80MP0001929_abnormal_gametogenesis1.15029661
81MP0000653_abnormal_sex_gland1.14979960
82MP0000678_abnormal_parathyroid_gland1.14636373
83MP0001293_anophthalmia1.14244217
84MP0002332_abnormal_exercise_endurance1.10997159
85MP0003119_abnormal_digestive_system1.10798951
86MP0001919_abnormal_reproductive_system1.09575037
87MP0002132_abnormal_respiratory_system1.09290263
88MP0002086_abnormal_extraembryonic_tissu1.09136219
89MP0009250_abnormal_appendicular_skeleto1.08574381
90MP0005266_abnormal_metabolism1.07947975
91MP0002095_abnormal_skin_pigmentation1.07415898
92MP0000003_abnormal_adipose_tissue1.06178736
93MP0002653_abnormal_ependyma_morphology1.04382982
94MP0000538_abnormal_urinary_bladder1.04310947
95MP0005384_cellular_phenotype1.04155378
96MP0003121_genomic_imprinting1.03521684
97MP0002138_abnormal_hepatobiliary_system1.03250031
98MP0005360_urolithiasis1.02919981
99MP0005646_abnormal_pituitary_gland1.02313145
100MP0001661_extended_life_span1.01934428
101MP0010307_abnormal_tumor_latency1.01015426
102MP0002254_reproductive_system_inflammat1.00895450
103MP0002638_abnormal_pupillary_reflex0.98231299
104MP0002084_abnormal_developmental_patter0.96118637
105MP0004197_abnormal_fetal_growth/weight/0.95447814
106MP0000858_altered_metastatic_potential0.95208915
107MP0001119_abnormal_female_reproductive0.94762539
108MP0010030_abnormal_orbit_morphology0.94386857
109MP0006036_abnormal_mitochondrial_physio0.93616449
110MP0001756_abnormal_urination0.91986184
111MP0005621_abnormal_cell_physiology0.91650533
112MP0003942_abnormal_urinary_system0.91510370
113MP0005395_other_phenotype0.89656551
114MP0005076_abnormal_cell_differentiation0.89589015
115MP0009333_abnormal_splenocyte_physiolog0.87434587
116MP0005330_cardiomyopathy0.87305166
117MP0005623_abnormal_meninges_morphology0.86567825
118MP0000371_diluted_coat_color0.86559344
119MP0008789_abnormal_olfactory_epithelium0.86386543
120MP0002249_abnormal_larynx_morphology0.86095799
121MP0002111_abnormal_tail_morphology0.84228745
122MP0000750_abnormal_muscle_regeneration0.81289892
123MP0001270_distended_abdomen0.81234404
124MP0005084_abnormal_gallbladder_morpholo0.78866816
125MP0000689_abnormal_spleen_morphology0.78573020
126MP0002722_abnormal_immune_system0.78066816
127MP0001944_abnormal_pancreas_morphology0.77494838
128MP0003567_abnormal_fetal_cardiomyocyte0.76743610
129MP0002269_muscular_atrophy0.75791514
130MP0000703_abnormal_thymus_morphology0.75539291
131MP0005257_abnormal_intraocular_pressure0.74607003
132MP0003936_abnormal_reproductive_system0.73546055
133MP0003448_altered_tumor_morphology0.73073853
134MP0004381_abnormal_hair_follicle0.72324576
135MP0003698_abnormal_male_reproductive0.70980665
136MP0005410_abnormal_fertilization0.70925167
137MP0004130_abnormal_muscle_cell0.70640574
138MP0003938_abnormal_ear_development0.69966328
139MP0002089_abnormal_postnatal_growth/wei0.69604641
140MP0001286_abnormal_eye_development0.68719905
141MP0005670_abnormal_white_adipose0.68531092
142MP0000681_abnormal_thyroid_gland0.68089657
143MP0001764_abnormal_homeostasis0.65911172
144MP0009672_abnormal_birth_weight0.65550243
145MP0000428_abnormal_craniofacial_morphol0.62257981
146MP0003878_abnormal_ear_physiology0.61975639
147MP0005377_hearing/vestibular/ear_phenot0.61975639
148MP0000343_altered_response_to0.61745643
149MP0005584_abnormal_enzyme/coenzyme_acti0.60924618
150MP0000470_abnormal_stomach_morphology0.60662988
151MP0002127_abnormal_cardiovascular_syste0.60606611
152MP0005379_endocrine/exocrine_gland_phen0.60092849
153MP0001186_pigmentation_phenotype0.60084066
154MP0009840_abnormal_foam_cell0.59474377
155MP0002751_abnormal_autonomic_nervous0.58062014
156MP0002075_abnormal_coat/hair_pigmentati0.57360407
157MP0001881_abnormal_mammary_gland0.57354543
158MP0005023_abnormal_wound_healing0.54042745
159MP0000613_abnormal_salivary_gland0.53702393
160MP0000566_synostosis0.53159674
161MP0000432_abnormal_head_morphology0.52745393

Predicted human phenotypes

RankGene SetZ-score
1Progressive external ophthalmoplegia (HP:0000590)5.98144635
2Breast hypoplasia (HP:0003187)5.33593850
3Birth length less than 3rd percentile (HP:0003561)5.07369906
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.57302941
5Chromsome breakage (HP:0040012)4.23262458
6Carpal bone hypoplasia (HP:0001498)4.02285646
7Progressive muscle weakness (HP:0003323)3.98114234
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.89213309
9Abnormality of alanine metabolism (HP:0010916)3.89213309
10Hyperalaninemia (HP:0003348)3.89213309
11Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.78636573
12Meckel diverticulum (HP:0002245)3.55086685
13Mitochondrial inheritance (HP:0001427)3.53361326
14Multiple enchondromatosis (HP:0005701)3.51805835
15Abnormal mitochondria in muscle tissue (HP:0008316)3.45084377
16Increased CSF lactate (HP:0002490)3.43709828
17Cerebral hypomyelination (HP:0006808)3.41622592
18Acute necrotizing encephalopathy (HP:0006965)3.36639085
19Lipid accumulation in hepatocytes (HP:0006561)3.32367237
20Microretrognathia (HP:0000308)3.30325781
21Hepatocellular necrosis (HP:0001404)3.30016021
22Abnormality of the ileum (HP:0001549)3.29071760
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26164275
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26164275
25Increased hepatocellular lipid droplets (HP:0006565)3.26084543
26Impulsivity (HP:0100710)3.24442101
27Trismus (HP:0000211)3.21546155
28External ophthalmoplegia (HP:0000544)3.19852056
29Rough bone trabeculation (HP:0100670)3.19209458
30Renal Fanconi syndrome (HP:0001994)3.17036345
31Hepatic necrosis (HP:0002605)3.13118190
32Patellar aplasia (HP:0006443)3.12943293
33Acute encephalopathy (HP:0006846)3.04109803
34Testicular atrophy (HP:0000029)3.03084774
35Aplasia/Hypoplasia of the patella (HP:0006498)3.01643842
36Increased intramyocellular lipid droplets (HP:0012240)2.97833707
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.97118857
38Squamous cell carcinoma (HP:0002860)2.92211424
39Abnormality of the preputium (HP:0100587)2.90281962
40Oral leukoplakia (HP:0002745)2.89745420
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.88266787
42Absent radius (HP:0003974)2.87798022
43Increased muscle lipid content (HP:0009058)2.86031083
44Proximal tubulopathy (HP:0000114)2.81928038
45Reticulocytopenia (HP:0001896)2.79563481
46Lactic acidosis (HP:0003128)2.78581233
47Premature ovarian failure (HP:0008209)2.78097054
48Granulocytopenia (HP:0001913)2.77463192
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.75005853
50Pallor (HP:0000980)2.74680978
51Abnormality of chromosome stability (HP:0003220)2.68251531
52Ependymoma (HP:0002888)2.67184923
53Concave nail (HP:0001598)2.66859600
54Glioma (HP:0009733)2.66730684
55Aplasia involving forearm bones (HP:0009822)2.66222556
56Absent forearm bone (HP:0003953)2.66222556
57Supernumerary spleens (HP:0009799)2.61953501
58Microvesicular hepatic steatosis (HP:0001414)2.60729529
59Bone marrow hypocellularity (HP:0005528)2.58636001
60Aplasia/hypoplasia of the humerus (HP:0006507)2.58498371
61Aplastic anemia (HP:0001915)2.56737459
62Generalized aminoaciduria (HP:0002909)2.56678167
63Neoplasm of the adrenal cortex (HP:0100641)2.56666253
64Selective tooth agenesis (HP:0001592)2.52832367
65Stomach cancer (HP:0012126)2.52153548
66Aplasia/Hypoplasia involving the musculature (HP:0001460)2.50574410
67Abnormal lung lobation (HP:0002101)2.48947082
68Secondary amenorrhea (HP:0000869)2.46581829
69Cleft eyelid (HP:0000625)2.46078909
70Small intestinal stenosis (HP:0012848)2.44155375
71Duodenal stenosis (HP:0100867)2.44155375
72Abnormality of the anterior horn cell (HP:0006802)2.42435442
73Degeneration of anterior horn cells (HP:0002398)2.42435442
74Ragged-red muscle fibers (HP:0003200)2.41005047
75Fused cervical vertebrae (HP:0002949)2.39722725
76Rhabdomyosarcoma (HP:0002859)2.39673060
77Absent thumb (HP:0009777)2.39483507
78Rectal fistula (HP:0100590)2.39448474
79Rectovaginal fistula (HP:0000143)2.39448474
80Progressive macrocephaly (HP:0004481)2.37139902
81Atrophy/Degeneration involving motor neurons (HP:0007373)2.37108970
82Hypoplasia of the radius (HP:0002984)2.36555062
83Cutaneous melanoma (HP:0012056)2.36178566
843-Methylglutaconic aciduria (HP:0003535)2.35879678
85Abnormal trabecular bone morphology (HP:0100671)2.35290792
86Broad distal phalanx of finger (HP:0009836)2.34087398
87Facial cleft (HP:0002006)2.32440180
88Abnormality of the lower motor neuron (HP:0002366)2.29339356
89Macrocytic anemia (HP:0001972)2.29189872
90Myopathic facies (HP:0002058)2.28021210
91Duplicated collecting system (HP:0000081)2.27988573
92Sparse eyelashes (HP:0000653)2.27346819
93Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26621814
94Bilateral microphthalmos (HP:0007633)2.25388461
95Exercise intolerance (HP:0003546)2.25339671
96Reduced antithrombin III activity (HP:0001976)2.24817587
97Type I transferrin isoform profile (HP:0003642)2.24421108
98Colon cancer (HP:0003003)2.24019347
99Neoplasm of the pancreas (HP:0002894)2.23522483
100Increased serum lactate (HP:0002151)2.21171529
101Medulloblastoma (HP:0002885)2.20873961
102Abnormality of the fetal cardiovascular system (HP:0010948)2.19221845
103Abnormal umbilical cord blood vessels (HP:0011403)2.19221845
104Single umbilical artery (HP:0001195)2.19221845
105Tracheoesophageal fistula (HP:0002575)2.17915216
106Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17056309
107Triphalangeal thumb (HP:0001199)2.16370711
108Megaloblastic anemia (HP:0001889)2.16195185
109Abnormality of cells of the erythroid lineage (HP:0012130)2.15313741
110Horseshoe kidney (HP:0000085)2.14974985
111Abnormal number of erythroid precursors (HP:0012131)2.14601060
112Aplasia/Hypoplasia of the earlobes (HP:0009906)2.13593288
113Rib fusion (HP:0000902)2.12021694
114Premature graying of hair (HP:0002216)2.10939704
115Cerebral edema (HP:0002181)2.10552040
116Ulnar bowing (HP:0003031)2.08506688
117Respiratory difficulties (HP:0002880)2.07202331
118Myelodysplasia (HP:0002863)2.06095665
119Congenital stationary night blindness (HP:0007642)2.03439195
120Poikiloderma (HP:0001029)2.02261353
121Vaginal fistula (HP:0004320)2.01643767
122Breast aplasia (HP:0100783)2.01507752
123Abnormality of pyrimidine metabolism (HP:0004353)2.01470646
124Abnormal spermatogenesis (HP:0008669)2.01329061
125Sloping forehead (HP:0000340)2.00007922
126Glycosuria (HP:0003076)1.99983727
127Abnormality of urine glucose concentration (HP:0011016)1.99983727
128Abnormality of the duodenum (HP:0002246)1.99692753
129Poor head control (HP:0002421)1.98903163
130Intestinal fistula (HP:0100819)1.98245572
131Cellular immunodeficiency (HP:0005374)1.97486807
132Amyotrophic lateral sclerosis (HP:0007354)1.96323637
133Type II lissencephaly (HP:0007260)1.95594140
134Delayed epiphyseal ossification (HP:0002663)1.95563255
135Abnormality of subcutaneous fat tissue (HP:0001001)1.93829924
136Hypertensive crisis (HP:0100735)1.93773064
137Abnormality of the renal collecting system (HP:0004742)1.93664136
138Breech presentation (HP:0001623)1.93436457
139Mesangial abnormality (HP:0001966)1.92517573
140Optic disc pallor (HP:0000543)1.92383813
141Nephroblastoma (Wilms tumor) (HP:0002667)1.90200512
142Lethargy (HP:0001254)1.89448464
143Aplasia/Hypoplasia of the breasts (HP:0010311)1.89303945
144Opisthotonus (HP:0002179)1.89229288
145Hypoplasia of the pons (HP:0012110)1.88550633
146Pendular nystagmus (HP:0012043)1.88390729
147Methylmalonic aciduria (HP:0012120)1.87256501
148Pancytopenia (HP:0001876)1.84700608
149Abdominal situs inversus (HP:0003363)1.84660481
150Abnormality of abdominal situs (HP:0011620)1.84660481
151Respiratory failure (HP:0002878)1.84630707
152Type 2 muscle fiber atrophy (HP:0003554)1.84518689
153Hyperthyroidism (HP:0000836)1.83034278
154Increased serum pyruvate (HP:0003542)1.82853728
155Abnormality of glycolysis (HP:0004366)1.82853728
156Progressive microcephaly (HP:0000253)1.81881383
157Abnormal protein glycosylation (HP:0012346)1.77506068
158Abnormal glycosylation (HP:0012345)1.77506068
159Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77506068
160Abnormal protein N-linked glycosylation (HP:0012347)1.77506068
161Short thumb (HP:0009778)1.77413235
162Attenuation of retinal blood vessels (HP:0007843)1.75794632
163Respiratory distress (HP:0002098)1.74620897
164Bowed forearm bones (HP:0003956)1.74197306
165Bowing of the arm (HP:0006488)1.74197306
166Dicarboxylic aciduria (HP:0003215)1.73143579
167Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73143579
168Exertional dyspnea (HP:0002875)1.72807789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.94666376
2PLK45.24364544
3BUB14.91312616
4ZAK3.61686807
5WEE13.39852802
6MARK13.00488738
7TTK3.00048930
8TRIB32.83574091
9VRK22.82673144
10STK162.72465820
11IRAK42.71012939
12EPHA22.45798926
13EIF2AK12.36430296
14SRPK12.26506942
15IRAK22.25926376
16ICK2.09679012
17CDC72.04349506
18WNK42.04071845
19CDK121.97653300
20IRAK11.88788415
21MAP2K31.87888822
22TESK21.86018469
23MAPK151.81457692
24PLK11.80345639
25TSSK61.69323050
26SMG11.68007086
27EIF2AK31.61319041
28NEK11.45985761
29PDK21.39569535
30PAK41.37772659
31PLK31.36981813
32CHEK21.32444238
33CDK81.30993926
34DYRK31.30188014
35AKT31.26555520
36EPHB21.23939862
37NEK21.21832751
38ATR1.21707158
39ILK1.17807719
40VRK11.16793667
41CDK71.14090507
42BRSK21.13184287
43PRKCI1.11958760
44PRKD31.11368602
45STK38L1.09906412
46RPS6KB21.09785602
47LATS21.09391022
48ACVR1B1.08592759
49SIK11.08043596
50AURKA1.01779355
51MAPK71.00746297
52GRK60.99185216
53PINK10.99113310
54PNCK0.98210059
55AURKB0.93864462
56LIMK10.89258792
57LRRK20.88353429
58NME10.88318771
59CHEK10.88298023
60KDR0.87522679
61STK100.85562274
62NME20.83862217
63TLK10.83698141
64GRK50.83411847
65BRSK10.82991906
66EIF2AK20.81812171
67TESK10.81508685
68EEF2K0.79131265
69MARK30.77653385
70DAPK30.75251937
71CSNK1G30.74991014
72GRK10.73659330
73MAPKAPK30.73066936
74MAP3K80.72731311
75PRKD20.69428439
76ADRBK10.68947184
77SIK20.67117467
78ADRBK20.66075764
79RPS6KA60.65631005
80STK40.64479846
81BRAF0.64469604
82BCKDK0.63834757
83MKNK10.62359710
84MAPK110.62325899
85ABL20.61809411
86MAP3K110.60759132
87PDPK10.57748859
88ATM0.57030615
89MTOR0.56775975
90PHKG20.56222904
91PHKG10.56222904
92CSNK1A1L0.55389595
93PAK10.55308948
94CDK20.55276782
95CDK90.54939289
96DYRK20.53373632
97RPS6KL10.52464493
98RPS6KC10.52464493
99MST1R0.52247775
100RPS6KA20.47458210
101RPS6KA40.47242780
102CSNK2A10.46611497
103MKNK20.46130194
104PIM20.45115468
105ALK0.43273583
106MELK0.43193206
107RPS6KA10.41297179
108CSF1R0.41153934
109ERN10.41103875
110PBK0.39387612
111PASK0.39172469
112CSNK2A20.39012968
113CDK10.38070442
114BLK0.37944919
115CDK11A0.37334319
116IKBKB0.37165160
117GRK70.36448578
118PRKG20.36390832
119TYRO30.36156635
120MUSK0.33568535
121CSNK1G20.33123262
122CDK40.32512992
123TAOK20.32327467
124CSNK1E0.32172569
125MAPKAPK50.31309307
126CDC42BPA0.31089817
127SCYL20.30765310
128CDK140.30420477
129CCNB10.30418069
130BRD40.27893649
131PIM10.26647693
132MATK0.23714918
133MAPK40.20983909
134RPS6KA50.19971814
135MOS0.18398348
136AKT20.18175395
137CAMK2G0.14808375
138ARAF0.14737499
139PRKDC0.13430813
140STK380.13414658
141MAP2K20.11681487
142PRKCD0.11058962
143MAP3K30.10783480

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62662440
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.28915521
3RNA polymerase_Homo sapiens_hsa030204.08276353
4Proteasome_Homo sapiens_hsa030504.03116459
5Mismatch repair_Homo sapiens_hsa034303.75593746
6Ribosome_Homo sapiens_hsa030103.45567861
7Spliceosome_Homo sapiens_hsa030403.01314151
8Pyrimidine metabolism_Homo sapiens_hsa002402.88769849
9Homologous recombination_Homo sapiens_hsa034402.85726604
10RNA transport_Homo sapiens_hsa030132.84219389
11Fanconi anemia pathway_Homo sapiens_hsa034602.70932805
12One carbon pool by folate_Homo sapiens_hsa006702.58146942
13Base excision repair_Homo sapiens_hsa034102.53434459
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38409329
15Nucleotide excision repair_Homo sapiens_hsa034202.36827435
16Vitamin B6 metabolism_Homo sapiens_hsa007502.32172552
17Cell cycle_Homo sapiens_hsa041102.13949113
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84907449
19Basal transcription factors_Homo sapiens_hsa030221.82914633
20Sulfur metabolism_Homo sapiens_hsa009201.82743301
21RNA degradation_Homo sapiens_hsa030181.75477595
22p53 signaling pathway_Homo sapiens_hsa041151.70077005
23Non-homologous end-joining_Homo sapiens_hsa034501.61473177
24Purine metabolism_Homo sapiens_hsa002301.56615963
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43809104
26Cardiac muscle contraction_Homo sapiens_hsa042601.35694524
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28938456
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27684651
29mRNA surveillance pathway_Homo sapiens_hsa030151.26746775
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.24950828
31Folate biosynthesis_Homo sapiens_hsa007901.24101490
32Fructose and mannose metabolism_Homo sapiens_hsa000511.20112340
33Epstein-Barr virus infection_Homo sapiens_hsa051691.19885219
34Pentose phosphate pathway_Homo sapiens_hsa000301.16450305
35Huntingtons disease_Homo sapiens_hsa050161.03864394
36Glutathione metabolism_Homo sapiens_hsa004801.01634246
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94348508
38Drug metabolism - other enzymes_Homo sapiens_hsa009830.93500892
39Collecting duct acid secretion_Homo sapiens_hsa049660.91841852
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90855348
41Arachidonic acid metabolism_Homo sapiens_hsa005900.89586664
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88684760
43Oxidative phosphorylation_Homo sapiens_hsa001900.87800711
44Biosynthesis of amino acids_Homo sapiens_hsa012300.87192357
45Arginine biosynthesis_Homo sapiens_hsa002200.86778707
46Parkinsons disease_Homo sapiens_hsa050120.85410916
47Pyruvate metabolism_Homo sapiens_hsa006200.85160131
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84814282
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83112009
50Galactose metabolism_Homo sapiens_hsa000520.82572562
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81973815
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.79937712
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77623052
54Selenocompound metabolism_Homo sapiens_hsa004500.73156327
55Bladder cancer_Homo sapiens_hsa052190.68708488
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67988829
57Linoleic acid metabolism_Homo sapiens_hsa005910.67411823
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64442126
59Lysosome_Homo sapiens_hsa041420.61187774
60Sulfur relay system_Homo sapiens_hsa041220.59530110
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59277938
62Oocyte meiosis_Homo sapiens_hsa041140.58634721
63Herpes simplex infection_Homo sapiens_hsa051680.58433473
64Carbon metabolism_Homo sapiens_hsa012000.55146301
65N-Glycan biosynthesis_Homo sapiens_hsa005100.53170732
66Regulation of autophagy_Homo sapiens_hsa041400.52987582
67Metabolic pathways_Homo sapiens_hsa011000.52882948
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52152367
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51374166
70Viral carcinogenesis_Homo sapiens_hsa052030.49958504
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49611654
72Vibrio cholerae infection_Homo sapiens_hsa051100.48944129
73Other glycan degradation_Homo sapiens_hsa005110.47338000
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44785542
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44082290
76Sphingolipid metabolism_Homo sapiens_hsa006000.43186572
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43073468
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41653441
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.41081344
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40029956
81Phenylalanine metabolism_Homo sapiens_hsa003600.39516238
82Peroxisome_Homo sapiens_hsa041460.39489066
83HTLV-I infection_Homo sapiens_hsa051660.39173907
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39013055
85Systemic lupus erythematosus_Homo sapiens_hsa053220.38926807
86Tryptophan metabolism_Homo sapiens_hsa003800.38534099
87Nitrogen metabolism_Homo sapiens_hsa009100.34192794
88Antigen processing and presentation_Homo sapiens_hsa046120.33666527
89Thyroid cancer_Homo sapiens_hsa052160.33475378
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.33372382
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32323346
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31920381
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31916959
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31696390
95Arginine and proline metabolism_Homo sapiens_hsa003300.31687035
96Mineral absorption_Homo sapiens_hsa049780.31459808
97Synaptic vesicle cycle_Homo sapiens_hsa047210.29867503
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26852510
99Fatty acid elongation_Homo sapiens_hsa000620.26275854
100Protein export_Homo sapiens_hsa030600.25848408
101Apoptosis_Homo sapiens_hsa042100.25777635
102Fat digestion and absorption_Homo sapiens_hsa049750.25048424
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.25008766
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24377462
105Alzheimers disease_Homo sapiens_hsa050100.24297239
106Basal cell carcinoma_Homo sapiens_hsa052170.24120435
107Tyrosine metabolism_Homo sapiens_hsa003500.20322279
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.19258183
109Legionellosis_Homo sapiens_hsa051340.19200057
110Chemical carcinogenesis_Homo sapiens_hsa052040.18711076
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18580342
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16867234
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16035983
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13867270
115beta-Alanine metabolism_Homo sapiens_hsa004100.13135703
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12736436
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12412484
118Renin-angiotensin system_Homo sapiens_hsa046140.10946109
119Retinol metabolism_Homo sapiens_hsa008300.09617099
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08781493
121Influenza A_Homo sapiens_hsa051640.07096968
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.05755006
123Primary immunodeficiency_Homo sapiens_hsa053400.05716376
124HIF-1 signaling pathway_Homo sapiens_hsa040660.03691110
125Hippo signaling pathway_Homo sapiens_hsa043900.03614418
126Shigellosis_Homo sapiens_hsa051310.03368023
127Vitamin digestion and absorption_Homo sapiens_hsa049770.02984645
128MicroRNAs in cancer_Homo sapiens_hsa052060.02740022
129Measles_Homo sapiens_hsa051620.02654389
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.01058872
131Small cell lung cancer_Homo sapiens_hsa052220.00789549

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