SNAP29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial calcium ion transport (GO:0006851)5.53007493
2fatty acid elongation (GO:0030497)4.58062459
3behavioral response to nicotine (GO:0035095)3.85329402
4DNA methylation involved in gamete generation (GO:0043046)3.74691963
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.65895251
6alpha-linolenic acid metabolic process (GO:0036109)3.59764765
7cysteine metabolic process (GO:0006534)3.59328386
8low-density lipoprotein particle clearance (GO:0034383)3.55786880
9antigen processing and presentation of endogenous antigen (GO:0019883)3.53623379
10* autophagic vacuole fusion (GO:0000046)3.53440727
11mitochondrial calcium ion homeostasis (GO:0051560)3.48432543
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47445033
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47445033
14protoporphyrinogen IX metabolic process (GO:0046501)3.42512248
15regulation of interferon-beta biosynthetic process (GO:0045357)3.42392111
16regulation of cholesterol storage (GO:0010885)3.41209705
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37947229
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36444389
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.36444389
20modulation by symbiont of host immune response (GO:0052553)3.36444389
21positive regulation by symbiont of host defense response (GO:0052509)3.36444389
22modulation by symbiont of host defense response (GO:0052031)3.36444389
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36444389
24intra-S DNA damage checkpoint (GO:0031573)3.33811884
25piRNA metabolic process (GO:0034587)3.31090534
26peptidyl-glutamic acid carboxylation (GO:0017187)3.30188981
27protein carboxylation (GO:0018214)3.30188981
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.29471790
29positive regulation of interferon-alpha production (GO:0032727)3.27458968
30positive regulation of gamma-delta T cell activation (GO:0046645)3.24785984
31urea metabolic process (GO:0019627)3.23145100
32urea cycle (GO:0000050)3.23145100
33L-phenylalanine catabolic process (GO:0006559)3.23012781
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.23012781
35ubiquinone biosynthetic process (GO:0006744)3.19630022
36aromatic amino acid family catabolic process (GO:0009074)3.18765519
37kynurenine metabolic process (GO:0070189)3.16443415
38plasma lipoprotein particle clearance (GO:0034381)3.14898877
39positive regulation of granulocyte differentiation (GO:0030854)3.13209696
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11247122
41indole-containing compound catabolic process (GO:0042436)3.10373387
42indolalkylamine catabolic process (GO:0046218)3.10373387
43tryptophan catabolic process (GO:0006569)3.10373387
44response to thyroid hormone (GO:0097066)3.08940706
45complement activation, alternative pathway (GO:0006957)3.07741026
46regulation of interferon-alpha production (GO:0032647)3.07681423
47regulation of memory T cell differentiation (GO:0043380)3.06100557
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.03282773
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.03019859
50L-phenylalanine metabolic process (GO:0006558)3.03019859
51positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.01659922
52positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.00934971
53amino-acid betaine metabolic process (GO:0006577)3.00204013
54sulfur amino acid catabolic process (GO:0000098)2.99531953
55macrophage activation involved in immune response (GO:0002281)2.98617338
56proteasome assembly (GO:0043248)2.97712225
57protein K6-linked ubiquitination (GO:0085020)2.96217917
58neutrophil activation (GO:0042119)2.95040163
59phosphatidylinositol acyl-chain remodeling (GO:0036149)2.91855198
60neutrophil activation involved in immune response (GO:0002283)2.91743381
61terpenoid biosynthetic process (GO:0016114)2.91712877
62tryptophan metabolic process (GO:0006568)2.90489314
63leukocyte degranulation (GO:0043299)2.89345281
64phospholipid homeostasis (GO:0055091)2.88395471
65regulation of triglyceride catabolic process (GO:0010896)2.87716894
66high-density lipoprotein particle remodeling (GO:0034375)2.84443325
67nitrogen cycle metabolic process (GO:0071941)2.83106610
68urate metabolic process (GO:0046415)2.82848937
69positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.82844265
70valine metabolic process (GO:0006573)2.82038500
71positive regulation of B cell differentiation (GO:0045579)2.80783141
72negative regulation of fibrinolysis (GO:0051918)2.79757543
73lysine metabolic process (GO:0006553)2.78919591
74lysine catabolic process (GO:0006554)2.78919591
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78231051
76diterpenoid biosynthetic process (GO:0016102)2.78046040
77positive regulation of lipid catabolic process (GO:0050996)2.77425267
78phospholipid efflux (GO:0033700)2.76601846
79positive regulation of mast cell activation (GO:0033005)2.76517070
80growth hormone receptor signaling pathway (GO:0060396)2.75066882
81actin nucleation (GO:0045010)2.72250079
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72206976
83mitochondrial respiratory chain complex I assembly (GO:0032981)2.72206976
84NADH dehydrogenase complex assembly (GO:0010257)2.72206976
85regulation of gamma-delta T cell differentiation (GO:0045586)2.70146276
86regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.69762127
87serine family amino acid catabolic process (GO:0009071)2.69549303
88regulation of protein activation cascade (GO:2000257)2.69010120
89regulation of cholesterol homeostasis (GO:2000188)2.68885739
90glyoxylate metabolic process (GO:0046487)2.67892754
91positive regulation of lipid storage (GO:0010884)2.67784400
92hepatocyte apoptotic process (GO:0097284)2.67542262
93carnitine metabolic process (GO:0009437)2.67214873
94negative regulation of sterol transport (GO:0032372)2.66901620
95negative regulation of cholesterol transport (GO:0032375)2.66901620
96ubiquinone metabolic process (GO:0006743)2.65924018
97L-methionine salvage (GO:0071267)2.64841056
98L-methionine biosynthetic process (GO:0071265)2.64841056
99amino acid salvage (GO:0043102)2.64841056
100thrombin receptor signaling pathway (GO:0070493)2.64624196
101ATP synthesis coupled proton transport (GO:0015986)2.64226514
102energy coupled proton transport, down electrochemical gradient (GO:0015985)2.64226514
103reverse cholesterol transport (GO:0043691)2.63492910
104cellular defense response (GO:0006968)2.63226575
105negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.62833778
106homocysteine metabolic process (GO:0050667)2.61865151
107regulation of sequestering of triglyceride (GO:0010889)2.61566096
108poly(A)+ mRNA export from nucleus (GO:0016973)2.61417697
109phosphatidylserine acyl-chain remodeling (GO:0036150)2.59834807
110JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.59620577
111bile acid biosynthetic process (GO:0006699)2.58798169
112regulation of mast cell activation (GO:0033003)2.58234702
113male meiosis I (GO:0007141)2.57929388
114myeloid cell activation involved in immune response (GO:0002275)2.57401217
115immunoglobulin mediated immune response (GO:0016064)2.57172898
116plasma lipoprotein particle remodeling (GO:0034369)2.57089620
117protein-lipid complex remodeling (GO:0034368)2.57089620
118macromolecular complex remodeling (GO:0034367)2.57089620
119regulation of complement activation (GO:0030449)2.56757955
120mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.56589598
121acetyl-CoA metabolic process (GO:0006084)2.56345758
122quinone biosynthetic process (GO:1901663)2.56027035
123cardiolipin metabolic process (GO:0032048)2.56000327
124regulation of mast cell degranulation (GO:0043304)2.53843756
125natural killer cell mediated cytotoxicity (GO:0042267)2.53308254
126natural killer cell mediated immunity (GO:0002228)2.53308254
1272-deoxyribonucleotide biosynthetic process (GO:0009265)2.52820964
128deoxyribose phosphate biosynthetic process (GO:0046385)2.52820964
129tolerance induction (GO:0002507)2.52197929
130gonadal mesoderm development (GO:0007506)2.51749018
131regulation of superoxide anion generation (GO:0032928)2.51404759
132protein-lipid complex assembly (GO:0065005)2.51161008
133protoporphyrinogen IX biosynthetic process (GO:0006782)2.51013466
134granulocyte activation (GO:0036230)2.50556732
135* organelle membrane fusion (GO:0090174)2.50509709
136electron transport chain (GO:0022900)2.50501723
137granulocyte differentiation (GO:0030851)2.49578328
138methionine biosynthetic process (GO:0009086)2.49234402
139regulation of interleukin-12 biosynthetic process (GO:0045075)2.48926564
140respiratory burst (GO:0045730)2.48584415
141respiratory electron transport chain (GO:0022904)2.48105814
142positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.46753686
143regulation of gamma-delta T cell activation (GO:0046643)2.46697567
144DNA replication checkpoint (GO:0000076)2.46393220
145regulation of mast cell activation involved in immune response (GO:0033006)2.45987089
146protein-cofactor linkage (GO:0018065)2.43812338
147B cell receptor signaling pathway (GO:0050853)2.43092830
148negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.42772606
149adenosine metabolic process (GO:0046085)2.42707697
150cholesterol efflux (GO:0033344)2.42223135
151negative regulation of lipid storage (GO:0010888)2.40980262
152hydrogen peroxide biosynthetic process (GO:0050665)2.40854708
153regulation of membrane protein ectodomain proteolysis (GO:0051043)2.40699508
154regulation of fatty acid beta-oxidation (GO:0031998)2.40537845
155regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.40160112
156positive regulation of interferon-beta production (GO:0032728)2.39529262
157negative regulation of erythrocyte differentiation (GO:0045647)2.39378358
158negative regulation of lipid transport (GO:0032369)2.39362225
159purinergic nucleotide receptor signaling pathway (GO:0035590)2.39001140
160drug transmembrane transport (GO:0006855)2.38673265
161negative regulation of DNA-templated transcription, elongation (GO:0032785)2.38536457
162regulation of B cell differentiation (GO:0045577)2.38532913
163DNA deamination (GO:0045006)2.37667058
164acute-phase response (GO:0006953)2.37532552
165positive regulation of lipoprotein lipase activity (GO:0051006)2.37401264
166positive regulation of triglyceride lipase activity (GO:0061365)2.37401264
167positive regulation of blood coagulation (GO:0030194)2.37301597
168positive regulation of hemostasis (GO:1900048)2.37301597
169cellular response to thyroid hormone stimulus (GO:0097067)2.37200062
170plasma lipoprotein particle assembly (GO:0034377)2.36977444
171virion assembly (GO:0019068)2.36860398
172regulation of fibrinolysis (GO:0051917)2.36816554
173meiotic chromosome segregation (GO:0045132)2.36613308
174succinate metabolic process (GO:0006105)2.34497871
175regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.34444204
176L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.34180635
177positive regulation of defense response to virus by host (GO:0002230)2.34080615
178oxygen transport (GO:0015671)2.34039082
179cellular response to growth hormone stimulus (GO:0071378)2.33274632
180GMP metabolic process (GO:0046037)2.31844220
181gas transport (GO:0015669)2.30602849
182intracellular pH reduction (GO:0051452)2.30401144
183positive regulation of T cell mediated cytotoxicity (GO:0001916)2.28673115
184negative regulation of gene silencing (GO:0060969)2.28623620
185tRNA modification (GO:0006400)2.27933073
186protein deneddylation (GO:0000338)2.27759292
187nucleoside transmembrane transport (GO:1901642)2.27199568
188synapsis (GO:0007129)2.25309865
189viral protein processing (GO:0019082)2.24025643
190sleep (GO:0030431)2.21382181
191pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.20180531

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.19990231
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.78430801
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.87441043
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.64770472
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.57909536
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.51590976
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.23210754
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14809595
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87344837
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.84041363
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73754149
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70405485
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.67260642
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63379147
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58815393
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57795578
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52428099
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45249673
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39874051
20SCL_19346495_ChIP-Seq_HPC-7_Human2.38999861
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.36861523
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.33234872
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30800800
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.28802024
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27330923
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18818791
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.16804215
28* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.14178452
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.13563705
30* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13313994
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12814958
32* NCOR1_26117541_ChIP-Seq_K562_Human2.06516556
33ETS1_20019798_ChIP-Seq_JURKAT_Human2.06461098
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.06335397
35SRF_21415370_ChIP-Seq_HL-1_Mouse2.04592575
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98596241
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95339712
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94567854
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92873272
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.90167770
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.88148414
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86942355
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.86185694
44GATA1_22025678_ChIP-Seq_K562_Human1.86164121
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.84936991
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82852169
47CLOCK_20551151_ChIP-Seq_293T_Human1.82007101
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75543193
49GABP_19822575_ChIP-Seq_HepG2_Human1.74418365
50MYC_22102868_ChIP-Seq_BL_Human1.73224880
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72335547
52E2F7_22180533_ChIP-Seq_HELA_Human1.71923735
53KDM5A_27292631_Chip-Seq_BREAST_Human1.69454275
54VDR_23849224_ChIP-Seq_CD4+_Human1.68096945
55DCP1A_22483619_ChIP-Seq_HELA_Human1.67690354
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.66788364
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66332036
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64906903
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64573550
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63096199
61* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62803436
62MAF_26560356_Chip-Seq_TH1_Human1.61176632
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58400072
64BCL6_27268052_Chip-Seq_Bcells_Human1.55358449
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52709576
66* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52404234
67MYB_26560356_Chip-Seq_TH2_Human1.52126842
68RUNX_20019798_ChIP-Seq_JUKART_Human1.50513406
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49634786
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49380922
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46192885
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.46051323
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.42935001
74CIITA_25753668_ChIP-Seq_RAJI_Human1.41615165
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40473012
76MYB_26560356_Chip-Seq_TH1_Human1.39723195
77* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39398535
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39224007
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38436977
80STAT1_20625510_ChIP-Seq_HELA_Human1.37099266
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35732919
82VDR_21846776_ChIP-Seq_THP-1_Human1.35633761
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33606826
84ELK1_19687146_ChIP-ChIP_HELA_Human1.33536418
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33287833
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33005479
87TCF7_22412390_ChIP-Seq_EML_Mouse1.32060852
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31340468
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31085004
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30789837
91VDR_24763502_ChIP-Seq_THP-1_Human1.30312336
92FOXP3_21729870_ChIP-Seq_TREG_Human1.30170973
93* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30157078
94* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29795757
95MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29062707
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28685489
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27820469
98UTX_26944678_Chip-Seq_JUKART_Human1.27011391
99TFEB_21752829_ChIP-Seq_HELA_Human1.26267705
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25836611
101XRN2_22483619_ChIP-Seq_HELA_Human1.25567822
102E2F1_20622854_ChIP-Seq_HELA_Human1.24934350
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.23710950
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.22627360
105PU_27001747_Chip-Seq_BMDM_Mouse1.22218895
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.21669992
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19882399
108CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17205294
109RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16802880
110* GATA3_27048872_Chip-Seq_THYMUS_Human1.16546325
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16526561
112SPI1_23547873_ChIP-Seq_NB4_Human1.16010235
113SPI1_23127762_ChIP-Seq_K562_Human1.15660923
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15431030
115VDR_24787735_ChIP-Seq_THP-1_Human1.15079947
116THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15020476
117ELF1_20517297_ChIP-Seq_JURKAT_Human1.14741325
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14540042
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14419455
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.13305193
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13291374
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12892970
123BCOR_27268052_Chip-Seq_Bcells_Human1.12528158
124P300_27268052_Chip-Seq_Bcells_Human1.12507582
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11803799
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11706156
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11614385
128* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10943231
129ERA_21632823_ChIP-Seq_H3396_Human1.10904939
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10866070
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10118747
132RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09800475
133GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09561930
134* KDM2B_26808549_Chip-Seq_DND41_Human1.09141515
135FOXA2_19822575_ChIP-Seq_HepG2_Human1.08453385
136HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08382579
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08152649
138SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07227203
139MAF_26560356_Chip-Seq_TH2_Human1.06000476
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05491646
141TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05444302
142EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05035876
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04829048
144KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04499071
145TET1_21451524_ChIP-Seq_MESCs_Mouse1.04450958
146GATA2_19941826_ChIP-Seq_K562_Human1.02607134
147GATA2_21666600_ChIP-Seq_HMVEC_Human1.02555720
148KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02480700
149NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02435462
150RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02367290
151GATA6_25053715_ChIP-Seq_YYC3_Human1.02280327
152GATA6_21074721_ChIP-Seq_CACO-2_Human1.02246863
153GATA1_19941826_ChIP-Seq_K562_Human1.01487958
154* GATA4_25053715_ChIP-Seq_YYC3_Human1.01338130
155CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00516972
156KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00392062
157SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00034747
158TRIM28_21343339_ChIP-Seq_HEK293_Human0.97977660
159ESR2_21235772_ChIP-Seq_MCF-7_Human0.97147376
160GATA3_26560356_Chip-Seq_TH2_Human0.92841527
161SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92417121
162SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92417121
163ZNF263_19887448_ChIP-Seq_K562_Human0.90497089
164P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88568384
165GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88140348
166ATF3_27146783_Chip-Seq_COLON_Human0.87104956
167GATA1_19941827_ChIP-Seq_MEL_Mouse0.86026297
168CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85817576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.95149170
2MP0005360_urolithiasis3.84295261
3MP0004147_increased_porphyrin_level2.97292062
4MP0009840_abnormal_foam_cell2.80777407
5MP0003303_peritoneal_inflammation2.66762970
6MP0005085_abnormal_gallbladder_physiolo2.64596431
7MP0001835_abnormal_antigen_presentation2.56293969
8MP0003436_decreased_susceptibility_to2.45597671
9MP0005365_abnormal_bile_salt2.42377326
10MP0004233_abnormal_muscle_weight2.42014925
11MP0003300_gastrointestinal_ulcer2.39157609
12MP0003705_abnormal_hypodermis_morpholog2.38992108
13MP0003252_abnormal_bile_duct2.17074417
14MP0003191_abnormal_cellular_cholesterol2.14501318
15MP0001727_abnormal_embryo_implantation2.06579550
16MP0005387_immune_system_phenotype1.97894379
17MP0001790_abnormal_immune_system1.97894379
18MP0009333_abnormal_splenocyte_physiolog1.97521813
19MP0010329_abnormal_lipoprotein_level1.94208436
20MP0000685_abnormal_immune_system1.92241975
21MP0008875_abnormal_xenobiotic_pharmacok1.90939130
22MP0001800_abnormal_humoral_immune1.90580640
23MP0006036_abnormal_mitochondrial_physio1.89159255
24MP0002138_abnormal_hepatobiliary_system1.87771688
25MP0003646_muscle_fatigue1.84423660
26MP0002419_abnormal_innate_immunity1.80676656
27MP0010234_abnormal_vibrissa_follicle1.78443073
28MP0005058_abnormal_lysosome_morphology1.77604156
29MP0002452_abnormal_antigen_presenting1.75671464
30MP0005000_abnormal_immune_tolerance1.75534254
31MP0004947_skin_inflammation1.74017369
32MP0006082_CNS_inflammation1.71066469
33MP0003656_abnormal_erythrocyte_physiolo1.67262181
34MP0000609_abnormal_liver_physiology1.66643714
35MP0005025_abnormal_response_to1.61224188
36MP0002653_abnormal_ependyma_morphology1.59106005
37MP0004043_abnormal_pH_regulation1.58203431
38MP0005464_abnormal_platelet_physiology1.57391483
39MP0009785_altered_susceptibility_to1.55413468
40MP0001666_abnormal_nutrient_absorption1.52689982
41MP0002723_abnormal_immune_serum1.51702709
42MP0002876_abnormal_thyroid_physiology1.51360036
43MP0001661_extended_life_span1.50371735
44MP0005083_abnormal_biliary_tract1.48163617
45MP0010352_gastrointestinal_tract_polyps1.42134868
46MP0002132_abnormal_respiratory_system1.41676388
47MP0003806_abnormal_nucleotide_metabolis1.40851527
48MP0009764_decreased_sensitivity_to1.40153502
49MP0001845_abnormal_inflammatory_respons1.38923213
50MP0002420_abnormal_adaptive_immunity1.38866184
51MP0001819_abnormal_immune_cell1.38643460
52MP0001853_heart_inflammation1.38110645
53MP0002166_altered_tumor_susceptibility1.36684868
54MP0003763_abnormal_thymus_physiology1.35805152
55MP0001533_abnormal_skeleton_physiology1.35145570
56MP0004130_abnormal_muscle_cell1.34539436
57MP0002148_abnormal_hypersensitivity_rea1.33691087
58MP0008995_early_reproductive_senescence1.33544279
59MP0005332_abnormal_amino_acid1.33520799
60MP0008260_abnormal_autophagy1.32942391
61MP0005451_abnormal_body_composition1.32450080
62MP0005671_abnormal_response_to1.30712903
63MP0008469_abnormal_protein_level1.30445925
64MP0006054_spinal_hemorrhage1.29562275
65MP0004185_abnormal_adipocyte_glucose1.25333880
66MP0003566_abnormal_cell_adhesion1.23363278
67MP0000465_gastrointestinal_hemorrhage1.22803286
68MP0002118_abnormal_lipid_homeostasis1.21131045
69MP0005319_abnormal_enzyme/_coenzyme1.20728319
70MP0004145_abnormal_muscle_electrophysio1.20243561
71MP0008872_abnormal_physiological_respon1.20120019
72MP0004883_abnormal_blood_vessel1.19790680
73MP0003195_calcinosis1.19396749
74MP0003453_abnormal_keratinocyte_physiol1.18110538
75MP0010155_abnormal_intestine_physiology1.17714187
76MP0002006_tumorigenesis1.15710173
77MP0009697_abnormal_copulation1.15446701
78MP0009643_abnormal_urine_homeostasis1.14707583
79MP0001764_abnormal_homeostasis1.14102864
80MP0004510_myositis1.13879988
81MP0000604_amyloidosis1.13512245
82MP0008775_abnormal_heart_ventricle1.13035823
83MP0003724_increased_susceptibility_to1.08735957
84MP0000716_abnormal_immune_system1.08013084
85MP0005584_abnormal_enzyme/coenzyme_acti1.07645002
86MP0003186_abnormal_redox_activity1.07100984
87MP0002398_abnormal_bone_marrow1.06407006
88MP0002405_respiratory_system_inflammati1.06210115
89MP0000689_abnormal_spleen_morphology1.04962657
90MP0000598_abnormal_liver_morphology1.02945192
91MP0003172_abnormal_lysosome_physiology1.01866396
92MP0009115_abnormal_fat_cell1.01515658
93MP0004019_abnormal_vitamin_homeostasis1.01465586
94MP0005636_abnormal_mineral_homeostasis1.00924273
95MP0002136_abnormal_kidney_physiology1.00230606
96MP0002877_abnormal_melanocyte_morpholog0.98456785
97MP0008877_abnormal_DNA_methylation0.97855745
98MP0006035_abnormal_mitochondrial_morpho0.97618356
99MP0002796_impaired_skin_barrier0.97084167
100MP0005666_abnormal_adipose_tissue0.96468157
101MP0000343_altered_response_to0.95749855
102MP0003448_altered_tumor_morphology0.95684848
103MP0000703_abnormal_thymus_morphology0.95353688
104MP0005166_decreased_susceptibility_to0.95132272
105MP0003183_abnormal_peptide_metabolism0.94270989
106MP0005076_abnormal_cell_differentiation0.94054358
107MP0000372_irregular_coat_pigmentation0.93607601
108MP0005164_abnormal_response_to0.93342113
109MP0001881_abnormal_mammary_gland0.92483091
110MP0009763_increased_sensitivity_to0.91325519
111MP0002998_abnormal_bone_remodeling0.91047685
112MP0003959_abnormal_lean_body0.90847032
113MP0003866_abnormal_defecation0.90777986
114MP0003638_abnormal_response/metabolism_0.89167643
115MP0002429_abnormal_blood_cell0.88890847
116MP0002254_reproductive_system_inflammat0.88870178
117MP0000858_altered_metastatic_potential0.88333169
118MP0005646_abnormal_pituitary_gland0.87796333
119MP0005023_abnormal_wound_healing0.87561341
120MP0003075_altered_response_to0.87426612
121MP0002722_abnormal_immune_system0.87372210
122MP0003786_premature_aging0.86116711
123MP0005535_abnormal_body_temperature0.85971338
124MP0000750_abnormal_muscle_regeneration0.84997439
125MP0000427_abnormal_hair_cycle0.84375542
126MP0003690_abnormal_glial_cell0.82835238
127MP0005670_abnormal_white_adipose0.82609489
128MP0005397_hematopoietic_system_phenotyp0.82479904
129MP0001545_abnormal_hematopoietic_system0.82479904
130MP0002971_abnormal_brown_adipose0.82086794
131MP0004142_abnormal_muscle_tone0.82079261
132MP0002970_abnormal_white_adipose0.81370300
133MP0005334_abnormal_fat_pad0.79285368
134MP0003011_delayed_dark_adaptation0.78058331
135MP0010307_abnormal_tumor_latency0.77978572
136MP0002933_joint_inflammation0.76814227
137MP0001915_intracranial_hemorrhage0.75661604
138MP0005376_homeostasis/metabolism_phenot0.74656446
139MP0003091_abnormal_cell_migration0.73333931
140MP0000249_abnormal_blood_vessel0.68830318
141MP0004264_abnormal_extraembryonic_tissu0.68662435
142MP0001873_stomach_inflammation0.68651024
143MP0009384_cardiac_valve_regurgitation0.67787130

Predicted human phenotypes

RankGene SetZ-score
1Hyperthyroidism (HP:0000836)4.82205015
2Petechiae (HP:0000967)4.81750809
3Truncus arteriosus (HP:0001660)4.51148266
4Recurrent gram-negative bacterial infections (HP:0005420)4.10628445
5Deep venous thrombosis (HP:0002625)4.02944387
6Eczematoid dermatitis (HP:0000976)4.00540666
7Recurrent bacterial skin infections (HP:0005406)3.83234626
8Prolonged bleeding time (HP:0003010)3.71524113
9Xanthomatosis (HP:0000991)3.70974103
10Abnormality of glycolipid metabolism (HP:0010969)3.63579426
11Abnormality of liposaccharide metabolism (HP:0010968)3.63579426
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.63579426
13Recurrent abscess formation (HP:0002722)3.55141459
14Myocardial infarction (HP:0001658)3.50495509
15Abnormality of alanine metabolism (HP:0010916)3.50492169
16Hyperalaninemia (HP:0003348)3.50492169
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.50492169
18Seborrheic dermatitis (HP:0001051)3.49110022
19Autoimmune thrombocytopenia (HP:0001973)3.44249456
20Purpura (HP:0000979)3.42629833
21Hypertensive crisis (HP:0100735)3.31373542
22Systemic lupus erythematosus (HP:0002725)3.31075671
23Complement deficiency (HP:0004431)3.29870897
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.19914053
25Intrahepatic cholestasis (HP:0001406)3.07818386
26Tetraparesis (HP:0002273)2.97778146
27Obstructive lung disease (HP:0006536)2.96862429
28Chronic obstructive pulmonary disease (HP:0006510)2.96862429
29Cellulitis (HP:0100658)2.91638457
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.91628630
31Hyperlipoproteinemia (HP:0010980)2.90404421
32Joint hemorrhage (HP:0005261)2.86305415
33Hypoparathyroidism (HP:0000829)2.82776485
34Abnormality of the common coagulation pathway (HP:0010990)2.79961654
35Epistaxis (HP:0000421)2.78112967
36Tinnitus (HP:0000360)2.76080545
37Abnormality of macrophages (HP:0004311)2.71786740
38Recurrent viral infections (HP:0004429)2.71496207
39Generalized aminoaciduria (HP:0002909)2.70884650
40Hypoalphalipoproteinemia (HP:0003233)2.69781394
41Abnormality of complement system (HP:0005339)2.68256592
42Mitral stenosis (HP:0001718)2.67250028
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.66560436
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.63035616
45Epidermoid cyst (HP:0200040)2.61805443
46Increased serum ferritin (HP:0003281)2.61450907
47Poikilocytosis (HP:0004447)2.57722029
48Reticulocytosis (HP:0001923)2.56329498
49Recurrent skin infections (HP:0001581)2.54290497
50Verrucae (HP:0200043)2.53613386
51Papilloma (HP:0012740)2.53613386
52Agammaglobulinemia (HP:0004432)2.53603677
53Increased IgM level (HP:0003496)2.51597109
54Abnormal pupillary function (HP:0007686)2.51566682
55Recurrent fungal infections (HP:0002841)2.50691707
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49603951
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49603951
58Pustule (HP:0200039)2.49492860
59Colitis (HP:0002583)2.46958707
60Hypolipoproteinemia (HP:0010981)2.43773276
61Menorrhagia (HP:0000132)2.41885369
62Hypobetalipoproteinemia (HP:0003563)2.39450085
63Abnormal mitochondria in muscle tissue (HP:0008316)2.38419633
64Abnormality of transition element cation homeostasis (HP:0011030)2.38336334
65Abnormal large intestine physiology (HP:0012700)2.37876625
66Axonal loss (HP:0003447)2.37644401
67Atelectasis (HP:0100750)2.36922193
68Hematochezia (HP:0002573)2.36298818
69Spontaneous hematomas (HP:0007420)2.36141581
703-Methylglutaconic aciduria (HP:0003535)2.35863210
71Polycythemia (HP:0001901)2.35287149
72Neoplasm of head and neck (HP:0012288)2.34883696
73Esophageal neoplasm (HP:0100751)2.34883696
74Abnormality of iron homeostasis (HP:0011031)2.34697720
75Glomerulonephritis (HP:0000099)2.34615135
76Interstitial pulmonary disease (HP:0006530)2.34590339
77Gingival bleeding (HP:0000225)2.34490236
78Abnormality of dental color (HP:0011073)2.33547656
79Acne (HP:0001061)2.32658624
80Vacuolated lymphocytes (HP:0001922)2.32283302
81Prolonged partial thromboplastin time (HP:0003645)2.30726241
82Increased cerebral lipofuscin (HP:0011813)2.28977962
83Urinary glycosaminoglycan excretion (HP:0003541)2.28526979
84Mucopolysacchariduria (HP:0008155)2.28526979
85Hepatic necrosis (HP:0002605)2.28027296
86Esophageal varix (HP:0002040)2.27254997
87Granulocytopenia (HP:0001913)2.26891204
88Bowel incontinence (HP:0002607)2.26777659
89Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26464723
90Abnormality of purine metabolism (HP:0004352)2.25107331
91Anorexia (HP:0002039)2.23425549
92Vasculitis (HP:0002633)2.18969370
93Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18804712
94Disinhibition (HP:0000734)2.18251311
95Hepatocellular carcinoma (HP:0001402)2.17538650
96Birth length less than 3rd percentile (HP:0003561)2.17409128
97Acute necrotizing encephalopathy (HP:0006965)2.17087540
98Hemorrhage of the eye (HP:0011885)2.16395925
99Nephritis (HP:0000123)2.15828683
100Sparse lateral eyebrow (HP:0005338)2.14731487
101Increased IgE level (HP:0003212)2.14159881
102Dysostosis multiplex (HP:0000943)2.13734549
103Urticaria (HP:0001025)2.13533561
104Concave nail (HP:0001598)2.13489612
105Abnormality of sulfur amino acid metabolism (HP:0004339)2.13285531
106Osteomyelitis (HP:0002754)2.12089958
107Paralysis (HP:0003470)2.11761092
108Periodontitis (HP:0000704)2.11688456
109Abnormal platelet function (HP:0011869)2.10750308
110Impaired platelet aggregation (HP:0003540)2.10750308
111Abnormal hemoglobin (HP:0011902)2.10596475
112Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.09574036
113Gastrointestinal stroma tumor (HP:0100723)2.08746271
114Large for gestational age (HP:0001520)2.08631190
115Hyperammonemia (HP:0001987)2.08497693
116Hypercholesterolemia (HP:0003124)2.07958948
117Lactic acidosis (HP:0003128)2.07170010
118Renal cortical cysts (HP:0000803)2.06975425
119Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06387437
120Abnormality of polysaccharide metabolism (HP:0011012)2.06387437
121Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06387437
122Nausea (HP:0002018)2.05586477
123Abnormality of the tricuspid valve (HP:0001702)2.04736216
124Fat malabsorption (HP:0002630)2.02516313
125Mitochondrial inheritance (HP:0001427)2.02164849
126Congenital stationary night blindness (HP:0007642)2.00345197
127Osteolytic defects of the hand bones (HP:0009699)2.00337229
128Osteolytic defects of the phalanges of the hand (HP:0009771)2.00337229
129Increased muscle lipid content (HP:0009058)1.99554487
130Increased CSF lactate (HP:0002490)1.99241281
131Upper limb muscle weakness (HP:0003484)1.98671289
132Inflammation of the large intestine (HP:0002037)1.96925731
133Myositis (HP:0100614)1.96618261
134Hyperglycinuria (HP:0003108)1.96480857
135Gout (HP:0001997)1.95489038
136Cerebral palsy (HP:0100021)1.95386821
137Mediastinal lymphadenopathy (HP:0100721)1.94838347
138Elevated erythrocyte sedimentation rate (HP:0003565)1.94821239
139Acute encephalopathy (HP:0006846)1.94704924
140Arterial thrombosis (HP:0004420)1.94553984
141Ketosis (HP:0001946)1.93049781
142Abnormality of the intrinsic pathway (HP:0010989)1.92825211
143Optic neuritis (HP:0100653)1.92309873
144Retrobulbar optic neuritis (HP:0100654)1.92309873
145Chronic otitis media (HP:0000389)1.91270220
146Gingivitis (HP:0000230)1.90801211
147Mucosal telangiectasiae (HP:0100579)1.90389157
148Orchitis (HP:0100796)1.89557129
149Increased serum lactate (HP:0002151)1.89429024
150Recurrent bronchitis (HP:0002837)1.88703688
151Hepatocellular necrosis (HP:0001404)1.88631351
152Stomatitis (HP:0010280)1.88087247
153Ileus (HP:0002595)1.88086007
154Beaking of vertebral bodies (HP:0004568)1.87487661
155Abnormality of nucleobase metabolism (HP:0010932)1.87344417
156Hyperbilirubinemia (HP:0002904)1.87019175
157Gastrointestinal inflammation (HP:0004386)1.86480336
158Abnormal gallbladder physiology (HP:0012438)1.85495412
159Cholecystitis (HP:0001082)1.85495412
160Abnormality of reticulocytes (HP:0004312)1.84689341
161Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84269128
162Pulmonary embolism (HP:0002204)1.84007091
163Hypokinesia (HP:0002375)1.83393544
164Protuberant abdomen (HP:0001538)1.81870535
165Meningitis (HP:0001287)1.81652808
166Peritonitis (HP:0002586)1.80687841
167Abnormality of proline metabolism (HP:0010907)1.80466853
168Hydroxyprolinuria (HP:0003080)1.80466853
169Abnormal platelet volume (HP:0011876)1.80312222
170Increased neuronal autofluorescent lipopigment (HP:0002074)1.79783661
171Opisthotonus (HP:0002179)1.79433584
172Abnormality of serine family amino acid metabolism (HP:0010894)1.79417980
173Abnormality of glycine metabolism (HP:0010895)1.79417980
174Increased CSF protein (HP:0002922)1.79246257
175Hypoglycemic coma (HP:0001325)1.78118900
176Conjunctival hamartoma (HP:0100780)1.75870857
177Encephalitis (HP:0002383)1.75653051
178Hypergammaglobulinemia (HP:0010702)1.75281236
179Autoimmune hemolytic anemia (HP:0001890)1.75244658
180Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75022303
181Gastrointestinal infarctions (HP:0005244)1.73997800
182Redundant skin (HP:0001582)1.73855220
183Aplasia/Hypoplasia of the thymus (HP:0010515)1.73784737
184Ulnar bowing (HP:0003031)1.73552904
185Subacute progressive viral hepatitis (HP:0006572)1.73240553
186Increased mean platelet volume (HP:0011877)1.68830199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.16641208
2EIF2AK13.36777822
3ERN13.19849150
4TXK2.96798617
5WNK42.65576104
6MAP3K102.64753706
7MAP4K12.43681851
8STK102.41359595
9TYK22.40740908
10AKT32.25804623
11FGFR42.25453256
12PKN22.22112900
13NME12.19837201
14TESK22.17440273
15TLK12.15606829
16TBK12.15024093
17MAP3K142.14204625
18LRRK22.12017798
19MAPKAPK32.03288831
20BLK2.02930285
21JAK11.76490169
22PIK3CG1.76081665
23JAK31.65143872
24ILK1.65079337
25ADRBK21.64511893
26PTK61.58340785
27RIPK11.58052034
28TAOK31.54413477
29GRK61.52986551
30STK31.50543141
31MAP3K111.49989887
32FGFR31.48672221
33CDK61.45457655
34INSRR1.44653311
35IRAK11.44227634
36EPHB11.43457125
37KSR11.43442507
38IRAK31.41924648
39SIK11.39246738
40STK161.36828427
41BMPR21.35483194
42NEK91.32322063
43EEF2K1.27149351
44LATS11.26014671
45CSK1.25567693
46ZAP701.24194407
47RPS6KA41.22666410
48MST1R1.20624379
49CSF1R1.20268917
50RIPK41.19853998
51TGFBR21.18357032
52SCYL21.13585784
53MARK31.13508595
54SYK1.13228321
55PBK1.12904581
56MATK1.12825954
57NTRK31.11178123
58PIM11.09431898
59MAP2K61.09160243
60STK241.06890728
61JAK21.06495914
62CAMK1D1.05593762
63BTK1.03224187
64FRK1.01513994
65MAP4K20.98753694
66MAP2K30.96475543
67MAP2K20.96036519
68FGFR20.95926454
69IKBKB0.95660911
70CLK10.95233727
71HCK0.94773820
72BMX0.94682755
73IKBKE0.94349358
74TTN0.93010075
75CDK190.92786623
76CDK120.89927283
77PTK2B0.89637272
78ITK0.89473286
79PIM20.89426069
80MAP3K30.89225267
81MAP3K10.88442445
82RAF10.88061074
83MYLK0.87493909
84BCKDK0.87187843
85MAP3K50.84647199
86IRAK40.79654297
87KIT0.79550669
88STK40.77131535
89CHUK0.76258120
90ADRBK10.75658413
91RET0.74492589
92BRAF0.74403643
93MAPK120.73774753
94TRPM70.72715102
95KSR20.71954340
96MAP3K80.70889902
97DMPK0.69314748
98CDK40.69081057
99ABL20.68023833
100MST40.66592530
101MAP3K20.65605321
102PRKD20.65389419
103EPHA30.65057189
104PDGFRA0.64538979
105PRKCQ0.63952161
106EGFR0.63376013
107LYN0.62896137
108PIK3CA0.60923826
109ACVR1B0.60467359
110PDGFRB0.60236404
111ABL10.59673170
112HIPK20.59501245
113MAPK110.59452760
114FES0.59216150
115DYRK1B0.59066839
116ALK0.58641484
117PDK10.58355774
118CCNB10.57883124
119LCK0.57700746
120PTK20.56365394
121TEC0.53646766
122FLT30.51929135
123PDPK10.51694590
124PAK10.50608442
125MAP3K130.49999102
126TAOK10.49478911
127FGR0.49205956
128CAMKK20.48768484
129MAPKAPK20.48628833
130PRKD10.47294671
131PRKCI0.47256568
132MELK0.45592096
133PINK10.43965658
134MAP3K120.42862324
135TESK10.42589578
136CAMK1G0.42145668
137MAPK40.42086268
138MAP2K10.41231230
139CDK90.40471768
140ERBB40.40142927
141NUAK10.39812405
142MTOR0.39587563
143AURKA0.39576035
144GSK3A0.39415391
145PDK20.39102835
146MET0.38438004
147MAP3K60.32385150
148RPS6KB20.31862036
149GRK70.30263896
150GRK10.28594532
151SIK30.28581535
152FER0.25985940

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.25237628
2Sulfur relay system_Homo sapiens_hsa041223.13722986
3Nitrogen metabolism_Homo sapiens_hsa009102.79948771
4Staphylococcus aureus infection_Homo sapiens_hsa051502.65668737
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.64482588
6Oxidative phosphorylation_Homo sapiens_hsa001902.58307695
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50735849
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40082790
9Proteasome_Homo sapiens_hsa030502.34757844
10Homologous recombination_Homo sapiens_hsa034402.30334175
11Caffeine metabolism_Homo sapiens_hsa002322.28527420
12Complement and coagulation cascades_Homo sapiens_hsa046102.27021778
13Parkinsons disease_Homo sapiens_hsa050122.20748576
14Other glycan degradation_Homo sapiens_hsa005112.20690985
15Arginine biosynthesis_Homo sapiens_hsa002202.11717891
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93677149
17Linoleic acid metabolism_Homo sapiens_hsa005911.89443200
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.87714520
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84717368
20Leishmaniasis_Homo sapiens_hsa051401.81304480
21Collecting duct acid secretion_Homo sapiens_hsa049661.81274762
22B cell receptor signaling pathway_Homo sapiens_hsa046621.80000984
23Tryptophan metabolism_Homo sapiens_hsa003801.78952084
24One carbon pool by folate_Homo sapiens_hsa006701.76911744
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74629910
26Fatty acid degradation_Homo sapiens_hsa000711.74451585
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71897781
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71454661
29PPAR signaling pathway_Homo sapiens_hsa033201.64390324
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59604221
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.50054130
32RNA polymerase_Homo sapiens_hsa030201.49797726
33* SNARE interactions in vesicular transport_Homo sapiens_hsa041301.47219865
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45149204
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44689558
36Osteoclast differentiation_Homo sapiens_hsa043801.42944084
37Huntingtons disease_Homo sapiens_hsa050161.39708503
38Pyrimidine metabolism_Homo sapiens_hsa002401.38219568
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38130429
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31491679
41Peroxisome_Homo sapiens_hsa041461.30525305
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28506567
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28428800
44Ribosome_Homo sapiens_hsa030101.25968175
45Alzheimers disease_Homo sapiens_hsa050101.23376667
46Arachidonic acid metabolism_Homo sapiens_hsa005901.22775645
47Regulation of autophagy_Homo sapiens_hsa041401.22722913
48Fatty acid metabolism_Homo sapiens_hsa012121.17913313
49Tuberculosis_Homo sapiens_hsa051521.16812122
50Lysosome_Homo sapiens_hsa041421.16524017
51Propanoate metabolism_Homo sapiens_hsa006401.15056441
52Histidine metabolism_Homo sapiens_hsa003401.13088021
53Legionellosis_Homo sapiens_hsa051341.12980058
54Selenocompound metabolism_Homo sapiens_hsa004501.11534669
55Toxoplasmosis_Homo sapiens_hsa051451.09856172
56beta-Alanine metabolism_Homo sapiens_hsa004101.02663496
57Fat digestion and absorption_Homo sapiens_hsa049751.01776909
58Pertussis_Homo sapiens_hsa051331.01637032
59Primary immunodeficiency_Homo sapiens_hsa053401.00042917
60Measles_Homo sapiens_hsa051620.99866316
61Fanconi anemia pathway_Homo sapiens_hsa034600.99572839
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.97565495
63Phototransduction_Homo sapiens_hsa047440.96903284
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96642143
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96371483
66Insulin resistance_Homo sapiens_hsa049310.95208808
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93607597
68Lysine degradation_Homo sapiens_hsa003100.91923447
69TNF signaling pathway_Homo sapiens_hsa046680.91448541
70Starch and sucrose metabolism_Homo sapiens_hsa005000.91176321
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91061180
72Antigen processing and presentation_Homo sapiens_hsa046120.90735352
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90330961
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.89143581
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87154445
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86638192
77Malaria_Homo sapiens_hsa051440.85975090
78Influenza A_Homo sapiens_hsa051640.85489242
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.84158384
80Mismatch repair_Homo sapiens_hsa034300.83001874
81Bile secretion_Homo sapiens_hsa049760.82940309
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.82862473
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.81614604
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80259266
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79779028
86Pancreatic cancer_Homo sapiens_hsa052120.79314069
87Steroid biosynthesis_Homo sapiens_hsa001000.79268897
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78670333
89Chemical carcinogenesis_Homo sapiens_hsa052040.78632651
90Chronic myeloid leukemia_Homo sapiens_hsa052200.78487238
91Apoptosis_Homo sapiens_hsa042100.78200241
92Shigellosis_Homo sapiens_hsa051310.77057469
93Fatty acid biosynthesis_Homo sapiens_hsa000610.76167494
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75318337
95Vitamin digestion and absorption_Homo sapiens_hsa049770.74904122
96Nucleotide excision repair_Homo sapiens_hsa034200.72867349
97ABC transporters_Homo sapiens_hsa020100.71135858
98Butanoate metabolism_Homo sapiens_hsa006500.70486614
99Rheumatoid arthritis_Homo sapiens_hsa053230.70329496
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69758406
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69331596
102Hepatitis C_Homo sapiens_hsa051600.68403244
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65644340
104Pentose phosphate pathway_Homo sapiens_hsa000300.64858155
105Retinol metabolism_Homo sapiens_hsa008300.64289842
106Purine metabolism_Homo sapiens_hsa002300.63497851
107Chemokine signaling pathway_Homo sapiens_hsa040620.63434544
108Glycerolipid metabolism_Homo sapiens_hsa005610.63042014
109Viral myocarditis_Homo sapiens_hsa054160.62639845
110Phenylalanine metabolism_Homo sapiens_hsa003600.62393317
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62355957
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61300189
113Carbon metabolism_Homo sapiens_hsa012000.60409620
114Acute myeloid leukemia_Homo sapiens_hsa052210.60027352
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.59967241
116Sulfur metabolism_Homo sapiens_hsa009200.59838204
117Salmonella infection_Homo sapiens_hsa051320.59331925
118Hematopoietic cell lineage_Homo sapiens_hsa046400.58900179
119Phagosome_Homo sapiens_hsa041450.58398766
120Prolactin signaling pathway_Homo sapiens_hsa049170.58326114
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57522306
122Ether lipid metabolism_Homo sapiens_hsa005650.56351795
123Herpes simplex infection_Homo sapiens_hsa051680.56338371
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.56205553
125Graft-versus-host disease_Homo sapiens_hsa053320.55808815
126Hepatitis B_Homo sapiens_hsa051610.54583257
127Thyroid cancer_Homo sapiens_hsa052160.54394159
128Metabolic pathways_Homo sapiens_hsa011000.54025631
129Small cell lung cancer_Homo sapiens_hsa052220.53215311
130Renal cell carcinoma_Homo sapiens_hsa052110.53109672
131Pyruvate metabolism_Homo sapiens_hsa006200.52631472
132Amoebiasis_Homo sapiens_hsa051460.51913948
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50769840
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50492936
135T cell receptor signaling pathway_Homo sapiens_hsa046600.50085767
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.49974135
137Glutathione metabolism_Homo sapiens_hsa004800.49962676
138mTOR signaling pathway_Homo sapiens_hsa041500.49384889
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48595747
140Platelet activation_Homo sapiens_hsa046110.47283518
141Base excision repair_Homo sapiens_hsa034100.46308453
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.45779923
143FoxO signaling pathway_Homo sapiens_hsa040680.45288699
144Sphingolipid metabolism_Homo sapiens_hsa006000.45269485
145VEGF signaling pathway_Homo sapiens_hsa043700.45014455
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45010224
147DNA replication_Homo sapiens_hsa030300.44936879
148Tyrosine metabolism_Homo sapiens_hsa003500.44721830
149Vibrio cholerae infection_Homo sapiens_hsa051100.40593928
150Non-small cell lung cancer_Homo sapiens_hsa052230.40379040
151Endocytosis_Homo sapiens_hsa041440.39080964

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