SNAP25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium ion export (GO:0071436)6.25988392
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.82135952
3regulation of synaptic vesicle exocytosis (GO:2000300)5.76378928
4vocalization behavior (GO:0071625)5.65487770
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.63876631
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.54712780
7regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.54057126
8neurotransmitter-gated ion channel clustering (GO:0072578)5.51198093
9* synaptic vesicle exocytosis (GO:0016079)5.49406662
10* glutamate secretion (GO:0014047)5.46285345
11presynaptic membrane assembly (GO:0097105)5.40572141
12neuron cell-cell adhesion (GO:0007158)5.22948509
13protein localization to synapse (GO:0035418)5.17788011
14* synaptic vesicle docking involved in exocytosis (GO:0016081)5.15824083
15neuronal action potential propagation (GO:0019227)5.15412841
16regulation of glutamate receptor signaling pathway (GO:1900449)5.09147172
17presynaptic membrane organization (GO:0097090)5.07394316
18regulation of synaptic vesicle transport (GO:1902803)5.01184835
19L-amino acid import (GO:0043092)4.98731637
20negative regulation of synaptic transmission, GABAergic (GO:0032229)4.85198368
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.78374164
22synaptic vesicle maturation (GO:0016188)4.71556599
23postsynaptic membrane organization (GO:0001941)4.68685380
24neuron-neuron synaptic transmission (GO:0007270)4.63787410
25cerebellar granule cell differentiation (GO:0021707)4.55656512
26synaptic transmission, glutamatergic (GO:0035249)4.55195731
27gamma-aminobutyric acid signaling pathway (GO:0007214)4.53067852
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.51157806
29amino acid import (GO:0043090)4.49269663
30potassium ion homeostasis (GO:0055075)4.47035013
31* neurotransmitter secretion (GO:0007269)4.40274898
32locomotory exploration behavior (GO:0035641)4.39073155
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.31586256
34positive regulation of synapse maturation (GO:0090129)4.30006934
35potassium ion import (GO:0010107)4.28000999
36response to histamine (GO:0034776)4.26057567
37glutamate receptor signaling pathway (GO:0007215)4.24273249
38transferrin transport (GO:0033572)4.12197367
39cell communication by electrical coupling (GO:0010644)4.10443394
40regulation of excitatory postsynaptic membrane potential (GO:0060079)4.08462642
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.04072264
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.02801223
43ATP hydrolysis coupled proton transport (GO:0015991)4.02801223
44cellular sodium ion homeostasis (GO:0006883)4.01917596
45neuronal ion channel clustering (GO:0045161)3.97298008
46positive regulation of neurotransmitter secretion (GO:0001956)3.93592997
47regulation of postsynaptic membrane potential (GO:0060078)3.92889780
48axon ensheathment in central nervous system (GO:0032291)3.88977492
49central nervous system myelination (GO:0022010)3.88977492
50regulation of neurotransmitter secretion (GO:0046928)3.84932924
51positive regulation of membrane potential (GO:0045838)3.84619288
52trivalent inorganic cation transport (GO:0072512)3.84369184
53ferric iron transport (GO:0015682)3.84369184
54* long-term synaptic potentiation (GO:0060291)3.83954161
55cerebellar Purkinje cell differentiation (GO:0021702)3.82656885
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.82465089
57positive regulation of neurotransmitter transport (GO:0051590)3.81572908
58neuromuscular process controlling balance (GO:0050885)3.81546143
59layer formation in cerebral cortex (GO:0021819)3.80904307
60positive regulation of dendritic spine development (GO:0060999)3.80754093
61mechanosensory behavior (GO:0007638)3.79653720
62negative regulation of dendrite morphogenesis (GO:0050774)3.78056879
63startle response (GO:0001964)3.77318859
64dendritic spine morphogenesis (GO:0060997)3.73703670
65regulation of ARF protein signal transduction (GO:0032012)3.71554912
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.71152099
67regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66355102
68regulation of neuronal synaptic plasticity (GO:0048168)3.65683539
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.60267023
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.59540911
71regulation of dendritic spine morphogenesis (GO:0061001)3.59078366
72* regulation of synaptic plasticity (GO:0048167)3.58771517
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55070142
74gamma-aminobutyric acid transport (GO:0015812)3.54874618
75* neurotransmitter transport (GO:0006836)3.54203417
76positive regulation of dendritic spine morphogenesis (GO:0061003)3.54085618
77regulation of synapse maturation (GO:0090128)3.53998808
78exploration behavior (GO:0035640)3.49835584
79behavioral response to cocaine (GO:0048148)3.49158526
80regulation of neurotransmitter transport (GO:0051588)3.48592352
81synaptic vesicle endocytosis (GO:0048488)3.45651216
82serotonin metabolic process (GO:0042428)3.43991202
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39045384
84acidic amino acid transport (GO:0015800)3.37908752
85regulation of voltage-gated calcium channel activity (GO:1901385)3.37754588
86positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36696608
87regulation of dendritic spine development (GO:0060998)3.35853179
88detection of calcium ion (GO:0005513)3.34958675
89positive regulation of synapse assembly (GO:0051965)3.29126319
90membrane depolarization (GO:0051899)3.27901330
91long-term memory (GO:0007616)3.27898096
92proline transport (GO:0015824)3.25800980
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24882928
94cell communication involved in cardiac conduction (GO:0086065)3.24420693
95regulation of glutamate secretion (GO:0014048)3.23915521
96* regulation of neurotransmitter levels (GO:0001505)3.22146004
97long term synaptic depression (GO:0060292)3.20967312
98auditory behavior (GO:0031223)3.19570821
99* positive regulation of synaptic transmission (GO:0050806)3.19140200
100transmission of nerve impulse (GO:0019226)3.19061344
101neuromuscular synaptic transmission (GO:0007274)3.18244965
102negative regulation of dendrite development (GO:2000171)3.18038967
103* synaptic transmission (GO:0007268)3.16327377
104regulation of vesicle fusion (GO:0031338)3.15044232
105regulation of exocytosis (GO:0017157)3.14638374
106neuromuscular process controlling posture (GO:0050884)3.12533247
107* synaptic vesicle transport (GO:0048489)3.11357567
108* establishment of synaptic vesicle localization (GO:0097480)3.11357567
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08503495
110* regulation of synaptic transmission (GO:0050804)3.08165009
111neuromuscular process (GO:0050905)3.07787499
112activation of protein kinase A activity (GO:0034199)3.06889289
113neuron recognition (GO:0008038)3.06427256
114NADH metabolic process (GO:0006734)3.06215876
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03953672
116regulation of female receptivity (GO:0045924)3.03802315
117membrane hyperpolarization (GO:0060081)3.03801324
118membrane depolarization during action potential (GO:0086010)3.03786149
119female mating behavior (GO:0060180)3.03237332
120dendritic spine organization (GO:0097061)3.03226268
121regulation of synapse structural plasticity (GO:0051823)3.02677171
122calcium ion-dependent exocytosis (GO:0017156)3.02098908
123cytoskeletal anchoring at plasma membrane (GO:0007016)3.01696712
124cerebellar Purkinje cell layer development (GO:0021680)3.00527618
125* signal release (GO:0023061)3.00275477
126learning (GO:0007612)3.00017423
127L-glutamate transport (GO:0015813)2.96153606
128cell differentiation in hindbrain (GO:0021533)2.93868383
129primary amino compound metabolic process (GO:1901160)2.92865403
130regulation of synaptic transmission, GABAergic (GO:0032228)2.92826612
131cellular potassium ion homeostasis (GO:0030007)2.92596622
132phagosome maturation (GO:0090382)2.90191589
133behavioral defense response (GO:0002209)2.88987782
134behavioral fear response (GO:0001662)2.88987782
135fear response (GO:0042596)2.86025053
136synapse assembly (GO:0007416)2.85714122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72666543
2* GBX2_23144817_ChIP-Seq_PC3_Human4.75816660
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13716517
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00845425
5TAF15_26573619_Chip-Seq_HEK293_Human2.88098623
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81008831
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.68075987
8* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.63633542
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56952453
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.45263667
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41237145
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41237145
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40755625
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39887095
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.38696516
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37407975
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34044565
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33229047
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.33054470
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26094739
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.25042495
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23304345
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.21857785
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20549955
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19305369
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17599510
27* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10308280
28SMAD4_21799915_ChIP-Seq_A2780_Human2.03521676
29DROSHA_22980978_ChIP-Seq_HELA_Human2.02752151
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99951119
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97260787
32P300_19829295_ChIP-Seq_ESCs_Human1.93044731
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91361348
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.89021574
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81953059
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.81830680
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80174737
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78534439
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.72182010
40AR_21572438_ChIP-Seq_LNCaP_Human1.71056840
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67994789
42FUS_26573619_Chip-Seq_HEK293_Human1.63156930
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62744732
44* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.60885604
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60348079
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.59530673
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57406534
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55877438
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55005576
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.53693792
51AR_25329375_ChIP-Seq_VCAP_Human1.53011889
52VDR_22108803_ChIP-Seq_LS180_Human1.48692646
53KDM2B_26808549_Chip-Seq_K562_Human1.44826447
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.43041492
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43033381
56* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41320734
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.41087133
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37797578
59STAT3_23295773_ChIP-Seq_U87_Human1.37500543
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36870125
61RNF2_27304074_Chip-Seq_NSC_Mouse1.35368436
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34460281
63TET1_21490601_ChIP-Seq_MESCs_Mouse1.30530625
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30488868
65* TCF4_23295773_ChIP-Seq_U87_Human1.30439202
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26510026
67* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25969982
68ER_23166858_ChIP-Seq_MCF-7_Human1.25437736
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23824864
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23295615
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21625640
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21224859
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.20925437
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20599546
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17749513
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16596295
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.14992569
78AR_19668381_ChIP-Seq_PC3_Human1.14410296
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.13389761
80* NANOG_18555785_Chip-Seq_ESCs_Mouse1.12523505
81* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12110011
82ZNF274_21170338_ChIP-Seq_K562_Hela1.12039277
83SOX9_26525672_Chip-Seq_HEART_Mouse1.10311348
84AHR_22903824_ChIP-Seq_MCF-7_Human1.09337376
85JUN_21703547_ChIP-Seq_K562_Human1.09077269
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09042237
87RUNX2_22187159_ChIP-Seq_PCA_Human1.08936164
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08564071
89* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07333285
90* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05901835
91* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05531120
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.05481545
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.05018896
94CTCF_27219007_Chip-Seq_Bcells_Human1.04637225
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04526304
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03173739
97* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02979164
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02513377
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01661797
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01001711
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00547467
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99962690
103* E2F1_18555785_Chip-Seq_ESCs_Mouse0.99560420
104TP53_18474530_ChIP-ChIP_U2OS_Human0.98214945
105IGF1R_20145208_ChIP-Seq_DFB_Human0.98114388
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96422385
107* P53_22387025_ChIP-Seq_ESCs_Mouse0.96232635
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.96202811
109KDM2B_26808549_Chip-Seq_REH_Human0.95591076
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95003335
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94630015
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94338151
113RXR_22108803_ChIP-Seq_LS180_Human0.93778562
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93486673
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93486673
116* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93481256
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93231450
118DPY_21335234_ChIP-Seq_ESCs_Mouse0.92935123
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92711862
120RING1B_27294783_Chip-Seq_ESCs_Mouse0.92008032
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90406881
122CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88076226
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87874805
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86170482
125OCT4_19829295_ChIP-Seq_ESCs_Human0.85723118
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.85550539
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83127374
128* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82468054
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78103861
130MYC_19915707_ChIP-ChIP_AK7_Human0.77464948
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76906479
132EGR1_19032775_ChIP-ChIP_M12_Human0.76457918
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76248331
134LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75460430
135KLF4_19829295_ChIP-Seq_ESCs_Human0.75340047
136KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75024497
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73615848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.95658594
2MP0004859_abnormal_synaptic_plasticity5.66109849
3* MP0003635_abnormal_synaptic_transmissio4.07824304
4MP0009745_abnormal_behavioral_response3.65484306
5MP0001968_abnormal_touch/_nociception3.58125549
6* MP0002064_seizures3.47603614
7* MP0009046_muscle_twitch3.46224890
8* MP0002063_abnormal_learning/memory/cond3.31786245
9MP0002736_abnormal_nociception_after3.18521610
10* MP0002572_abnormal_emotion/affect_behav3.00534994
11MP0002272_abnormal_nervous_system2.82385622
12MP0001501_abnormal_sleep_pattern2.48589594
13MP0001486_abnormal_startle_reflex2.46509300
14MP0009780_abnormal_chondrocyte_physiolo2.42236359
15MP0002735_abnormal_chemical_nociception2.37625293
16MP0002067_abnormal_sensory_capabilities2.37401605
17MP0003787_abnormal_imprinting2.36661254
18MP0005646_abnormal_pituitary_gland2.35200581
19* MP0004270_analgesia2.33441344
20* MP0002734_abnormal_mechanical_nocicepti2.33253384
21MP0003879_abnormal_hair_cell2.30206870
22MP0001440_abnormal_grooming_behavior2.19225940
23MP0002822_catalepsy2.17508358
24MP0001984_abnormal_olfaction1.99206642
25MP0001970_abnormal_pain_threshold1.87839004
26MP0008569_lethality_at_weaning1.87081513
27MP0004924_abnormal_behavior1.82981762
28MP0005386_behavior/neurological_phenoty1.82981762
29MP0002733_abnormal_thermal_nociception1.82200172
30MP0003122_maternal_imprinting1.81610321
31MP0005423_abnormal_somatic_nervous1.77728033
32MP0003690_abnormal_glial_cell1.73191044
33MP0002557_abnormal_social/conspecific_i1.69517077
34MP0006276_abnormal_autonomic_nervous1.66157006
35MP0000920_abnormal_myelination1.64107022
36MP0002184_abnormal_innervation1.60099699
37MP0002876_abnormal_thyroid_physiology1.59239851
38MP0001188_hyperpigmentation1.58947870
39MP0004811_abnormal_neuron_physiology1.58120098
40MP0002837_dystrophic_cardiac_calcinosis1.51251603
41MP0004142_abnormal_muscle_tone1.48785196
42MP0001529_abnormal_vocalization1.48553131
43MP0000778_abnormal_nervous_system1.43791965
44MP0001905_abnormal_dopamine_level1.43788198
45* MP0002066_abnormal_motor_capabilities/c1.38863927
46MP0001502_abnormal_circadian_rhythm1.35351700
47MP0002909_abnormal_adrenal_gland1.34862697
48MP0004147_increased_porphyrin_level1.33317385
49MP0003633_abnormal_nervous_system1.31521239
50MP0002882_abnormal_neuron_morphology1.27289081
51MP0003183_abnormal_peptide_metabolism1.25039197
52MP0003329_amyloid_beta_deposits1.23595329
53MP0000955_abnormal_spinal_cord1.23151017
54MP0000751_myopathy1.17292337
55MP0008872_abnormal_physiological_respon1.14453117
56MP0008877_abnormal_DNA_methylation1.11205359
57MP0005551_abnormal_eye_electrophysiolog1.10319561
58MP0003631_nervous_system_phenotype1.09567949
59MP0003634_abnormal_glial_cell1.09272274
60MP0000013_abnormal_adipose_tissue1.06653155
61MP0000604_amyloidosis1.05640702
62MP0005645_abnormal_hypothalamus_physiol1.01069460
63MP0010386_abnormal_urinary_bladder1.00518972
64MP0008874_decreased_physiological_sensi1.00414744
65MP0005171_absent_coat_pigmentation0.99758626
66MP0001348_abnormal_lacrimal_gland0.99138688
67MP0008004_abnormal_stomach_pH0.98322254
68MP0002229_neurodegeneration0.96866633
69MP0004145_abnormal_muscle_electrophysio0.96323566
70MP0004215_abnormal_myocardial_fiber0.95232424
71MP0004858_abnormal_nervous_system0.94879756
72MP0002653_abnormal_ependyma_morphology0.93826819
73MP0002069_abnormal_eating/drinking_beha0.91359972
74* MP0002152_abnormal_brain_morphology0.91232043
75MP0004742_abnormal_vestibular_system0.90115836
76MP0003075_altered_response_to0.87645943
77* MP0001963_abnormal_hearing_physiology0.86547656
78MP0004085_abnormal_heartbeat0.86203642
79MP0004484_altered_response_of0.85945133
80MP0002638_abnormal_pupillary_reflex0.84660614
81MP0004043_abnormal_pH_regulation0.82040905
82MP0003646_muscle_fatigue0.81228334
83MP0001346_abnormal_lacrimal_gland0.81207265
84MP0005535_abnormal_body_temperature0.80748406
85MP0001664_abnormal_digestion0.79135098
86MP0005167_abnormal_blood-brain_barrier0.77913490
87MP0005623_abnormal_meninges_morphology0.76828414
88MP0004885_abnormal_endolymph0.72573166
89MP0003121_genomic_imprinting0.70599834
90MP0005499_abnormal_olfactory_system0.70498342
91MP0005394_taste/olfaction_phenotype0.70498342
92MP0004233_abnormal_muscle_weight0.69881125
93MP0000631_abnormal_neuroendocrine_gland0.69513750
94MP0002752_abnormal_somatic_nervous0.65146559
95MP0001485_abnormal_pinna_reflex0.62515584
96MP0003632_abnormal_nervous_system0.62440477
97MP0003123_paternal_imprinting0.60853645
98MP0003172_abnormal_lysosome_physiology0.60821559
99MP0006035_abnormal_mitochondrial_morpho0.57655852
100MP0001177_atelectasis0.57208624
101MP0003137_abnormal_impulse_conducting0.55507863
102MP0004036_abnormal_muscle_relaxation0.55046328
103* MP0002082_postnatal_lethality0.53548837
104* MP0010770_preweaning_lethality0.53548837
105* MP0001943_abnormal_respiration0.52802977
106* MP0010769_abnormal_survival0.51850660
107MP0000026_abnormal_inner_ear0.51580912
108MP0003283_abnormal_digestive_organ0.49861798
109MP0004130_abnormal_muscle_cell0.49851489
110* MP0003956_abnormal_body_size0.49623723
111MP0001986_abnormal_taste_sensitivity0.49554491
112* MP0010768_mortality/aging0.49327407
113MP0004510_myositis0.48247771
114MP0000569_abnormal_digit_pigmentation0.47986532
115MP0008260_abnormal_autophagy0.47295881
116MP0002090_abnormal_vision0.46825816
117MP0000639_abnormal_adrenal_gland0.46109404
118MP0000579_abnormal_nail_morphology0.45652763
119MP0002873_normal_phenotype0.43708900
120MP0001765_abnormal_ion_homeostasis0.43224316
121MP0003861_abnormal_nervous_system0.42051704
122MP0002169_no_abnormal_phenotype0.42005857

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.27267745
2Epileptic encephalopathy (HP:0200134)6.77008398
3Atonic seizures (HP:0010819)6.63525077
4Focal seizures (HP:0007359)5.83042018
5Hyperventilation (HP:0002883)5.75965795
6Febrile seizures (HP:0002373)5.73610825
7Myokymia (HP:0002411)5.21406413
8Supranuclear gaze palsy (HP:0000605)5.10367147
9Absence seizures (HP:0002121)4.95837440
10Dialeptic seizures (HP:0011146)4.60444486
11Progressive cerebellar ataxia (HP:0002073)4.25967435
12Visual hallucinations (HP:0002367)4.16289848
13Broad-based gait (HP:0002136)4.09203448
14Generalized tonic-clonic seizures (HP:0002069)4.04182359
15Neurofibrillary tangles (HP:0002185)3.89356165
16Gaze-evoked nystagmus (HP:0000640)3.84848247
17Papilledema (HP:0001085)3.78355293
18Mutism (HP:0002300)3.70772931
19Cerebral hypomyelination (HP:0006808)3.64881548
20Annular pancreas (HP:0001734)3.55895775
21Tetraplegia (HP:0002445)3.46745978
22Dysmetric saccades (HP:0000641)3.44864428
23Abnormal hair whorl (HP:0010721)3.38760137
24Impaired vibration sensation in the lower limbs (HP:0002166)3.38230045
25Obstructive sleep apnea (HP:0002870)3.27705409
26Intention tremor (HP:0002080)3.24565067
27Cerebral inclusion bodies (HP:0100314)3.21547498
28Poor eye contact (HP:0000817)3.19800576
29Pheochromocytoma (HP:0002666)3.13101861
30Abnormal eating behavior (HP:0100738)3.13037274
31Neuronal loss in central nervous system (HP:0002529)3.12777047
32Epileptiform EEG discharges (HP:0011182)3.07057697
33Dysdiadochokinesis (HP:0002075)3.05828610
34Amblyopia (HP:0000646)3.02563285
35Delusions (HP:0000746)3.00428461
36Truncal ataxia (HP:0002078)2.94101013
37Protruding tongue (HP:0010808)2.92230537
38Abnormal social behavior (HP:0012433)2.87799088
39Impaired social interactions (HP:0000735)2.87799088
40Akinesia (HP:0002304)2.84729453
41Neuroendocrine neoplasm (HP:0100634)2.84620207
42Craniofacial dystonia (HP:0012179)2.84045169
43Lower limb muscle weakness (HP:0007340)2.81753680
44Gait imbalance (HP:0002141)2.79303123
45Excessive salivation (HP:0003781)2.73671248
46Drooling (HP:0002307)2.73671248
47Impaired smooth pursuit (HP:0007772)2.73077862
48Action tremor (HP:0002345)2.66876893
49Scanning speech (HP:0002168)2.66465480
50Clonus (HP:0002169)2.64867870
51Congenital primary aphakia (HP:0007707)2.64841580
52Inability to walk (HP:0002540)2.64009650
53Polyphagia (HP:0002591)2.62964544
54Depression (HP:0000716)2.61700242
55Dysmetria (HP:0001310)2.61179115
56EEG with generalized epileptiform discharges (HP:0011198)2.60378177
57Medial flaring of the eyebrow (HP:0010747)2.57098754
58Sleep apnea (HP:0010535)2.55756265
59Peripheral hypomyelination (HP:0007182)2.55562507
60Nephrogenic diabetes insipidus (HP:0009806)2.54026298
61Impaired vibratory sensation (HP:0002495)2.53920438
62Urinary bladder sphincter dysfunction (HP:0002839)2.52401561
63Status epilepticus (HP:0002133)2.50936541
64Rigidity (HP:0002063)2.47775689
65Oligomenorrhea (HP:0000876)2.47750167
66Failure to thrive in infancy (HP:0001531)2.46677907
67Apathy (HP:0000741)2.45454008
68Anxiety (HP:0000739)2.45450898
69Absent speech (HP:0001344)2.43338974
70Blue irides (HP:0000635)2.40685103
71Choreoathetosis (HP:0001266)2.39280337
72Abnormality of the labia minora (HP:0012880)2.38638979
73Hypsarrhythmia (HP:0002521)2.37861517
74Abnormal mitochondria in muscle tissue (HP:0008316)2.37121220
75Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.36899793
76Degeneration of the lateral corticospinal tracts (HP:0002314)2.36899793
77Genetic anticipation (HP:0003743)2.36685564
78Sensory axonal neuropathy (HP:0003390)2.35293521
79Poor suck (HP:0002033)2.34077912
80Abnormality of the lower motor neuron (HP:0002366)2.33607574
81Diplopia (HP:0000651)2.32085073
82Abnormality of binocular vision (HP:0011514)2.32085073
83Fetal akinesia sequence (HP:0001989)2.31364704
84Acute necrotizing encephalopathy (HP:0006965)2.30786565
85CNS hypomyelination (HP:0003429)2.30493749
86Abnormality of ocular smooth pursuit (HP:0000617)2.29427611
87Spastic tetraparesis (HP:0001285)2.27885848
88Hyperthyroidism (HP:0000836)2.25503655
89Resting tremor (HP:0002322)2.24064627
90Specific learning disability (HP:0001328)2.22837832
91Insomnia (HP:0100785)2.21198803
92Diminished motivation (HP:0000745)2.20759503
93Rapidly progressive (HP:0003678)2.20683879
94Ventricular fibrillation (HP:0001663)2.19573694
95Progressive inability to walk (HP:0002505)2.18315041
96Bradykinesia (HP:0002067)2.17099581
97Termporal pattern (HP:0011008)2.16310683
98Insidious onset (HP:0003587)2.16310683
99Morphological abnormality of the pyramidal tract (HP:0002062)2.16021058
100Postural instability (HP:0002172)2.13133750
101Progressive macrocephaly (HP:0004481)2.11244608
102Stereotypic behavior (HP:0000733)2.10608845
103Cholecystitis (HP:0001082)2.07544409
104Abnormal gallbladder physiology (HP:0012438)2.07544409
105Incomplete penetrance (HP:0003829)2.06363188
106Narrow nasal bridge (HP:0000446)2.06350140
107Generalized myoclonic seizures (HP:0002123)2.05122138
108Gait ataxia (HP:0002066)2.04498392
109Limb dystonia (HP:0002451)2.04212093
110Poor coordination (HP:0002370)2.03111545
111Focal dystonia (HP:0004373)2.01184490
112Hypoventilation (HP:0002791)2.00934882
113Ankle clonus (HP:0011448)2.00499014
114Lower limb asymmetry (HP:0100559)1.99016162
115Increased circulating renin level (HP:0000848)1.98821675
116Bundle branch block (HP:0011710)1.98365964
117Urinary urgency (HP:0000012)1.96607788
118Torticollis (HP:0000473)1.95805334
119Increased serum pyruvate (HP:0003542)1.95009581
120Abnormality of glycolysis (HP:0004366)1.95009581
121Slow saccadic eye movements (HP:0000514)1.93402779
122Genital tract atresia (HP:0001827)1.89743188
123Vaginal atresia (HP:0000148)1.88899842
124Spastic gait (HP:0002064)1.87177208
125Memory impairment (HP:0002354)1.86063409
126Spinal canal stenosis (HP:0003416)1.85960015
127Fair hair (HP:0002286)1.84254693
128Abnormality of saccadic eye movements (HP:0000570)1.83818976
129Generalized hypopigmentation of hair (HP:0011358)1.83169804
130Amyotrophic lateral sclerosis (HP:0007354)1.81178874
131Mitochondrial inheritance (HP:0001427)1.81053538
132Esotropia (HP:0000565)1.81000473
133Hemiplegia (HP:0002301)1.78738107
134Abnormality of the corticospinal tract (HP:0002492)1.78333376
135Abnormality of salivation (HP:0100755)1.78319963
136Hemiparesis (HP:0001269)1.78106339
137Unsteady gait (HP:0002317)1.76711824
138Limb ataxia (HP:0002070)1.75396118
139Thickened helices (HP:0000391)1.73093137
140Spastic tetraplegia (HP:0002510)1.72953281
141Lower limb amyotrophy (HP:0007210)1.69096855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.31636102
2CDK193.73795593
3NTRK33.65108388
4MAP3K123.44517933
5EPHA43.44223958
6MAP3K43.40480855
7MAP2K73.38521449
8DAPK22.96469605
9CCNB12.61373824
10DAPK12.47786624
11AKT32.47089896
12MAP3K92.30992250
13PLK22.29123747
14MAP2K42.16255799
15OXSR11.99676227
16PRPF4B1.94573948
17LATS21.87265841
18MINK11.84530105
19TSSK61.63136828
20RIPK41.60524646
21CAMKK21.55389833
22SIK31.53576550
23RIPK11.44363881
24GRK51.32214584
25PAK61.30388769
26ARAF1.26605715
27SGK21.22570999
28PDK41.22520146
29PDK31.22520146
30KSR11.20544326
31PHKG11.19035698
32PHKG21.19035698
33PRKCG1.17376594
34CAMKK11.16980855
35CDK51.16151922
36SGK4941.11463472
37SGK2231.11463472
38NTRK21.06605245
39MAPK131.06320829
40MARK11.05838609
41PAK31.01724615
42CAMK2A1.01087163
43BRAF1.01072145
44PTK2B0.99527782
45TYRO30.97877511
46KSR20.96038800
47TNIK0.94676838
48NME10.94530264
49ALK0.91514171
50CDK180.89963303
51CAMK2B0.89524694
52BMPR20.85541838
53CDK150.81113940
54SGK30.81003436
55FES0.80272872
56MARK20.78373223
57CDK140.76613738
58NEK10.76146342
59PNCK0.75254837
60LIMK10.74679020
61PDK20.73888692
62DAPK30.73333713
63CDK11A0.69301729
64BRSK10.68437908
65MAP3K110.66989941
66WNK10.66961002
67MAPK100.65931741
68STK380.61572497
69CAMK10.61194242
70BCR0.60923682
71PRKCE0.59746176
72PDK10.59731317
73MAP3K130.59153125
74MAPK70.58585983
75NTRK10.58135122
76PKN10.57326500
77SGK10.57193561
78MYLK0.57091299
79UHMK10.56479568
80FGFR20.55778492
81STK110.55459706
82PDPK10.52053455
83TNK20.51912702
84TESK10.50297074
85ADRBK10.48695922
86MAP3K20.48218475
87FER0.47303968
88PRKCH0.46153083
89RAF10.45625266
90PRKCZ0.44773896
91MAPK120.44235505
92CAMK2G0.42906130
93CAMK2D0.42622766
94DYRK1A0.41875804
95FYN0.41783688
96CDK30.41636976
97CAMK40.40669395
98SIK20.40242179
99LMTK20.38425397
100PRKD30.37003300
101MAP2K10.36728739
102FGR0.36366619
103WNK30.36052215
104RET0.35573328
105ADRBK20.34657382
106CDK80.33992683
107MAP3K10.32949068
108MAPKAPK50.32406850
109TAOK10.31170302
110MAP3K60.31012516
111RPS6KA30.30727316
112PINK10.29999242
113CSNK1G20.27640147
114GRK70.26990802
115ROCK20.26529009
116IRAK20.26452099
117* PRKACA0.24142760
118PRKG20.23675384
119SRC0.23027194
120MAPK80.22843520
121MAP2K60.22663331
122NEK60.22600994
123PRKCB0.22506265
124JAK20.22457780
125* PRKCA0.21355619
126PRKG10.20390415

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.34068301
2* Synaptic vesicle cycle_Homo sapiens_hsa047214.28531899
3Collecting duct acid secretion_Homo sapiens_hsa049663.48762384
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.89555448
5Olfactory transduction_Homo sapiens_hsa047402.66409176
6Amphetamine addiction_Homo sapiens_hsa050312.66156363
7Long-term potentiation_Homo sapiens_hsa047202.66073428
8Circadian entrainment_Homo sapiens_hsa047132.62040575
9GABAergic synapse_Homo sapiens_hsa047272.59624774
10Morphine addiction_Homo sapiens_hsa050322.58949541
11Glutamatergic synapse_Homo sapiens_hsa047242.32919498
12Vibrio cholerae infection_Homo sapiens_hsa051102.11388410
13Dopaminergic synapse_Homo sapiens_hsa047282.09492769
14Salivary secretion_Homo sapiens_hsa049702.00702968
15Taste transduction_Homo sapiens_hsa047421.92042563
16* Insulin secretion_Homo sapiens_hsa049111.74375159
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73122123
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69887704
19Renin secretion_Homo sapiens_hsa049241.69661401
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67701336
21Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.66082233
22Serotonergic synapse_Homo sapiens_hsa047261.64822775
23Long-term depression_Homo sapiens_hsa047301.63351245
24Gastric acid secretion_Homo sapiens_hsa049711.59450826
25Calcium signaling pathway_Homo sapiens_hsa040201.54093182
26Oxidative phosphorylation_Homo sapiens_hsa001901.53761824
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52282911
28Cholinergic synapse_Homo sapiens_hsa047251.49594907
29Vitamin B6 metabolism_Homo sapiens_hsa007501.49465978
30Oxytocin signaling pathway_Homo sapiens_hsa049211.47987567
31Cocaine addiction_Homo sapiens_hsa050301.44285026
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30256722
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23045845
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21077927
35Phototransduction_Homo sapiens_hsa047441.19412871
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18044197
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13557111
38cAMP signaling pathway_Homo sapiens_hsa040241.08834758
39GnRH signaling pathway_Homo sapiens_hsa049121.07564767
40Gap junction_Homo sapiens_hsa045401.05817308
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04477762
42Rheumatoid arthritis_Homo sapiens_hsa053231.03769412
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99780239
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97873592
45Alzheimers disease_Homo sapiens_hsa050100.97750676
46Cardiac muscle contraction_Homo sapiens_hsa042600.94239389
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89925440
48Type II diabetes mellitus_Homo sapiens_hsa049300.89743670
49ErbB signaling pathway_Homo sapiens_hsa040120.89013668
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88291723
51Parkinsons disease_Homo sapiens_hsa050120.86529482
52Bile secretion_Homo sapiens_hsa049760.84146621
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81931823
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81618513
55Estrogen signaling pathway_Homo sapiens_hsa049150.81411613
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.79262753
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77882014
58Pyruvate metabolism_Homo sapiens_hsa006200.76822892
59Glioma_Homo sapiens_hsa052140.74806708
60Axon guidance_Homo sapiens_hsa043600.73377504
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73362756
62Circadian rhythm_Homo sapiens_hsa047100.72398750
63Prion diseases_Homo sapiens_hsa050200.71097153
64Melanogenesis_Homo sapiens_hsa049160.69520778
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67858330
66Phagosome_Homo sapiens_hsa041450.67229727
67Oocyte meiosis_Homo sapiens_hsa041140.63277346
68MAPK signaling pathway_Homo sapiens_hsa040100.62372521
69Glucagon signaling pathway_Homo sapiens_hsa049220.59634296
70Pancreatic secretion_Homo sapiens_hsa049720.58822768
71Huntingtons disease_Homo sapiens_hsa050160.56881333
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56612438
73Dilated cardiomyopathy_Homo sapiens_hsa054140.51432391
74Inositol phosphate metabolism_Homo sapiens_hsa005620.51186509
75Type I diabetes mellitus_Homo sapiens_hsa049400.50751306
76Thyroid hormone synthesis_Homo sapiens_hsa049180.47872701
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.47811862
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47266202
79Arginine biosynthesis_Homo sapiens_hsa002200.46931865
80Ras signaling pathway_Homo sapiens_hsa040140.45446456
81Mineral absorption_Homo sapiens_hsa049780.43321684
82Arginine and proline metabolism_Homo sapiens_hsa003300.42091463
83Alcoholism_Homo sapiens_hsa050340.35290289
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34709720
85Fatty acid biosynthesis_Homo sapiens_hsa000610.33352663
86African trypanosomiasis_Homo sapiens_hsa051430.32143519
87Regulation of autophagy_Homo sapiens_hsa041400.31509279
88Dorso-ventral axis formation_Homo sapiens_hsa043200.30919320
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30468350
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30296837
91Rap1 signaling pathway_Homo sapiens_hsa040150.30030995
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.29520854
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29365367
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28975384
95Choline metabolism in cancer_Homo sapiens_hsa052310.27931803
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.27762847
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26630630
98Histidine metabolism_Homo sapiens_hsa003400.24624304
99Insulin signaling pathway_Homo sapiens_hsa049100.24613799
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.23775754
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23299163
102Fructose and mannose metabolism_Homo sapiens_hsa000510.22987153
103AMPK signaling pathway_Homo sapiens_hsa041520.22740228
104Melanoma_Homo sapiens_hsa052180.20404968
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20315801
106beta-Alanine metabolism_Homo sapiens_hsa004100.20300870
107Carbon metabolism_Homo sapiens_hsa012000.19664870
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19649378
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19473665
110Wnt signaling pathway_Homo sapiens_hsa043100.18885852
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18837194
112Ovarian steroidogenesis_Homo sapiens_hsa049130.18823058
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18773067
114HIF-1 signaling pathway_Homo sapiens_hsa040660.18224424
115Endocytosis_Homo sapiens_hsa041440.17248366
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17094428
117Tight junction_Homo sapiens_hsa045300.16563186
118VEGF signaling pathway_Homo sapiens_hsa043700.16177475
119mTOR signaling pathway_Homo sapiens_hsa041500.15494422
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13825523

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