SMYD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)5.52976769
2purine nucleobase biosynthetic process (GO:0009113)5.24133706
3proline biosynthetic process (GO:0006561)4.94347566
4establishment of integrated proviral latency (GO:0075713)4.83344607
5formation of translation preinitiation complex (GO:0001731)4.75510114
6DNA strand elongation involved in DNA replication (GO:0006271)4.69871890
7ribosome biogenesis (GO:0042254)4.65275757
8ribosome assembly (GO:0042255)4.59947862
9DNA replication initiation (GO:0006270)4.57427369
10IMP biosynthetic process (GO:0006188)4.56868179
11maturation of SSU-rRNA (GO:0030490)4.53232032
12regulation of translational fidelity (GO:0006450)4.49804443
13DNA strand elongation (GO:0022616)4.45770914
14DNA unwinding involved in DNA replication (GO:0006268)4.38926834
15mitotic metaphase plate congression (GO:0007080)4.33367855
16telomere maintenance via semi-conservative replication (GO:0032201)4.28258775
17protein localization to kinetochore (GO:0034501)4.22505177
18mitotic nuclear envelope disassembly (GO:0007077)4.21186216
19DNA replication checkpoint (GO:0000076)4.20594882
20COPI coating of Golgi vesicle (GO:0048205)4.17000526
21Golgi transport vesicle coating (GO:0048200)4.17000526
22folic acid-containing compound biosynthetic process (GO:0009396)4.15308875
23DNA deamination (GO:0045006)4.08012933
24protein complex localization (GO:0031503)4.07713008
25establishment of viral latency (GO:0019043)4.05468358
26ribonucleoprotein complex biogenesis (GO:0022613)4.03965775
27ribosomal small subunit assembly (GO:0000028)4.01477499
28nuclear envelope disassembly (GO:0051081)3.90871924
29membrane disassembly (GO:0030397)3.90871924
30IMP metabolic process (GO:0046040)3.89043542
31cellular protein complex localization (GO:0034629)3.82250080
32heterochromatin organization (GO:0070828)3.81279875
33pseudouridine synthesis (GO:0001522)3.76889077
34nuclear pore organization (GO:0006999)3.76265551
35folic acid metabolic process (GO:0046655)3.75468175
36telomere maintenance via recombination (GO:0000722)3.73968856
37rRNA processing (GO:0006364)3.73119760
38DNA replication-dependent nucleosome assembly (GO:0006335)3.73103529
39DNA replication-dependent nucleosome organization (GO:0034723)3.73103529
40ribosomal large subunit biogenesis (GO:0042273)3.73033018
41metaphase plate congression (GO:0051310)3.62977063
42spliceosomal snRNP assembly (GO:0000387)3.62592101
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.62366789
44rRNA metabolic process (GO:0016072)3.61884757
45telomere maintenance via telomere lengthening (GO:0010833)3.59514880
46rRNA modification (GO:0000154)3.57589311
47mitotic chromosome condensation (GO:0007076)3.56434625
48regulation of spindle organization (GO:0090224)3.53321748
49mitotic recombination (GO:0006312)3.52420048
50protein localization to chromosome, centromeric region (GO:0071459)3.50626239
51peptidyl-arginine N-methylation (GO:0035246)3.50193665
52peptidyl-arginine methylation (GO:0018216)3.50193665
53spliceosomal tri-snRNP complex assembly (GO:0000244)3.43504316
54proline metabolic process (GO:0006560)3.41935596
55maturation of 5.8S rRNA (GO:0000460)3.40549429
56proteasome assembly (GO:0043248)3.39315433
57CENP-A containing nucleosome assembly (GO:0034080)3.33602074
58peptidyl-arginine omega-N-methylation (GO:0035247)3.30339481
59nuclear pore complex assembly (GO:0051292)3.29875620
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29059797
61chromatin remodeling at centromere (GO:0031055)3.28248860
62translational initiation (GO:0006413)3.28061299
63regulation of translational termination (GO:0006449)3.27505643
64L-serine metabolic process (GO:0006563)3.25733865
65somatic hypermutation of immunoglobulin genes (GO:0016446)3.25688773
66somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25688773
67mitotic sister chromatid segregation (GO:0000070)3.25460910
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.23964669
69protein maturation by protein folding (GO:0022417)3.21257208
70establishment of chromosome localization (GO:0051303)3.20560432
71pore complex assembly (GO:0046931)3.20477982
72DNA replication-independent nucleosome organization (GO:0034724)3.20261308
73DNA replication-independent nucleosome assembly (GO:0006336)3.20261308
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19481450
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.19425862
76termination of RNA polymerase I transcription (GO:0006363)3.16597542
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16042996
78DNA duplex unwinding (GO:0032508)3.15803010
79transcription elongation from RNA polymerase I promoter (GO:0006362)3.15645031
80DNA geometric change (GO:0032392)3.14705015
81tRNA aminoacylation (GO:0043039)3.12641499
82amino acid activation (GO:0043038)3.12641499
83regulation of mammary gland epithelial cell proliferation (GO:0033599)3.12130932
84histone arginine methylation (GO:0034969)3.12075477
85regulation of nuclear cell cycle DNA replication (GO:0033262)3.11217141
86nuclear envelope organization (GO:0006998)3.10136535
87negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.09750180
88transcription-coupled nucleotide-excision repair (GO:0006283)3.08702944
89regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08469424
90G1/S transition of mitotic cell cycle (GO:0000082)3.07988947
91cell cycle G1/S phase transition (GO:0044843)3.07988947
92NADPH regeneration (GO:0006740)3.06620207
93pre-miRNA processing (GO:0031054)3.06498249
94ribosomal small subunit biogenesis (GO:0042274)3.06480535
95transcription from RNA polymerase I promoter (GO:0006360)3.06248224
96regulation of translation in response to stress (GO:0043555)3.05821994
97negative regulation of mRNA processing (GO:0050686)3.05786862
98negative regulation of chromosome segregation (GO:0051985)3.05645716
99translational termination (GO:0006415)3.05204678
100viral transcription (GO:0019083)3.04824994
101pentose-phosphate shunt (GO:0006098)3.02976643
102histone H2A acetylation (GO:0043968)3.00687537
103negative regulation of mitotic sister chromatid separation (GO:2000816)3.00220519
104negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00220519
105negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00220519
106negative regulation of sister chromatid segregation (GO:0033046)3.00220519
107translational elongation (GO:0006414)2.99312243
108mitochondrial DNA metabolic process (GO:0032042)2.99198568
109attachment of spindle microtubules to kinetochore (GO:0008608)2.99120734
110mitotic spindle assembly checkpoint (GO:0007094)2.98702574
111protein-DNA complex disassembly (GO:0032986)2.98095254
112nucleosome disassembly (GO:0006337)2.98095254
113cellular component biogenesis (GO:0044085)2.96583966
114spindle assembly checkpoint (GO:0071173)2.96048881
115DNA topological change (GO:0006265)2.95937027
116spindle checkpoint (GO:0031577)2.95620692
117GDP-mannose metabolic process (GO:0019673)2.94434238
118ncRNA processing (GO:0034470)2.92949552
119tRNA aminoacylation for protein translation (GO:0006418)2.92394363
120spliceosomal complex assembly (GO:0000245)2.92139327
121regulation of mitotic spindle organization (GO:0060236)2.92086903
122termination of RNA polymerase III transcription (GO:0006386)2.91412412
123transcription elongation from RNA polymerase III promoter (GO:0006385)2.91412412
124kinetochore organization (GO:0051383)2.91289150
125rRNA methylation (GO:0031167)2.90584192
126RNA splicing, via transesterification reactions (GO:0000375)2.90192943
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90188004
128negative regulation of ligase activity (GO:0051352)2.90188004
129protein export from nucleus (GO:0006611)2.89745467
130viral mRNA export from host cell nucleus (GO:0046784)2.87846078
131negative regulation of mRNA metabolic process (GO:1903312)2.87257487
132sister chromatid segregation (GO:0000819)2.86454636
133rRNA transcription (GO:0009303)2.82495643
134peptidyl-histidine modification (GO:0018202)2.80433488
135protein retention in ER lumen (GO:0006621)2.77923267
136maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75991566
137nucleobase-containing small molecule interconversion (GO:0015949)2.74298270
138positive regulation of chromosome segregation (GO:0051984)2.70751855
139negative regulation of RNA splicing (GO:0033119)2.70524035
140tRNA methylation (GO:0030488)2.66124251
141nucleotide-sugar biosynthetic process (GO:0009226)2.64534750
142mRNA splicing, via spliceosome (GO:0000398)2.62976113
143RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.62976113
144DNA conformation change (GO:0071103)2.60143502
145negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.58697665
146cellular hyperosmotic response (GO:0071474)2.58118963
147glucose catabolic process (GO:0006007)2.57520196
148regulation of translational elongation (GO:0006448)2.56859304
149retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.55303596
150mitochondrial fusion (GO:0008053)2.55012686
151regulation of double-strand break repair via homologous recombination (GO:0010569)2.53639893
152base-excision repair (GO:0006284)2.53375677
153nuclear envelope reassembly (GO:0031468)2.52955187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.96154252
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.57782951
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88731064
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.44864212
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35404889
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.28744056
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03294851
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02749267
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.01831166
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01433556
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.00039186
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.98431659
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75562713
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.74757199
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63539346
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60673897
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40508888
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36177979
19XRN2_22483619_ChIP-Seq_HELA_Human2.35396799
20VDR_23849224_ChIP-Seq_CD4+_Human2.22763396
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13162575
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09126228
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05250678
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.00313248
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00258587
26GABP_19822575_ChIP-Seq_HepG2_Human1.99476588
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.99002810
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.98415523
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97693851
30ZNF263_19887448_ChIP-Seq_K562_Human1.95886370
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95161296
32AR_21909140_ChIP-Seq_LNCAP_Human1.93358578
33DCP1A_22483619_ChIP-Seq_HELA_Human1.93309214
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90499387
35* E2F1_21310950_ChIP-Seq_MCF-7_Human1.88322492
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87788290
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87677607
38MYC_22102868_ChIP-Seq_BL_Human1.84870491
39CIITA_25753668_ChIP-Seq_RAJI_Human1.84216359
40TTF2_22483619_ChIP-Seq_HELA_Human1.80707366
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77653931
42* YY1_21170310_ChIP-Seq_MESCs_Mouse1.76997698
43* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74912853
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71827418
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71044199
46* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70672769
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62290052
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58017034
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56787577
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56348918
51KDM5A_27292631_Chip-Seq_BREAST_Human1.56035560
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49404815
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49088767
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.47279484
55* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47162435
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46845087
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42087837
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41378786
59ELK1_19687146_ChIP-ChIP_HELA_Human1.38964505
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37574575
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34652235
62* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32530704
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.31353881
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30419026
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29177123
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.26186951
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26159076
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25869824
69LXR_22292898_ChIP-Seq_THP-1_Human1.23011427
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22876741
71TFEB_21752829_ChIP-Seq_HELA_Human1.21285513
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21276612
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21020067
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20342739
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19888776
76RACK7_27058665_Chip-Seq_MCF-7_Human1.19747783
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18952226
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17802672
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16939378
80CLOCK_20551151_ChIP-Seq_293T_Human1.16874358
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15828721
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13327650
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12535502
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.12474498
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12018014
86* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11393550
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09440107
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08804240
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08325280
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07657622
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07581719
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07087985
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06622533
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.06238395
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06108299
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04501314
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03944576
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03153054
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03020412
100ATF3_27146783_Chip-Seq_COLON_Human1.02713538
101TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02170445
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01378245
103FOXP1_21924763_ChIP-Seq_HESCs_Human1.00847666
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99373608
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98113488
106TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97856210
107* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97748344
108VDR_21846776_ChIP-Seq_THP-1_Human0.96915690
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96808485
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.96334722
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96033815
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95444997
113P68_20966046_ChIP-Seq_HELA_Human0.93411784
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93056056
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92873132
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91957188
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87674006
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85669848
119ELK1_22589737_ChIP-Seq_MCF10A_Human0.85263944
120MYC_18940864_ChIP-ChIP_HL60_Human0.84854920
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84668185
122RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84573430
123OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84387336
124NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83441355
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83438432
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81370999
127SPI1_23547873_ChIP-Seq_NB4_Human0.80729067
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78359889
129SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77836649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.11606787
2MP0003111_abnormal_nucleus_morphology5.28526094
3MP0010094_abnormal_chromosome_stability4.91714174
4MP0004957_abnormal_blastocyst_morpholog4.83473914
5MP0003077_abnormal_cell_cycle4.26520783
6MP0008057_abnormal_DNA_replication4.07137981
7MP0008058_abnormal_DNA_repair3.60987288
8MP0002396_abnormal_hematopoietic_system3.08137458
9MP0008007_abnormal_cellular_replicative2.96512128
10MP0003123_paternal_imprinting2.94048834
11MP0001730_embryonic_growth_arrest2.76801389
12MP0008932_abnormal_embryonic_tissue2.76621019
13MP0000350_abnormal_cell_proliferation2.45123208
14MP0005451_abnormal_body_composition2.42727117
15MP0010352_gastrointestinal_tract_polyps2.23374186
16MP0003786_premature_aging2.22405788
17MP0003718_maternal_effect2.07925733
18MP0005380_embryogenesis_phenotype2.05875736
19MP0001672_abnormal_embryogenesis/_devel2.05875736
20MP0010307_abnormal_tumor_latency1.95826863
21MP0008877_abnormal_DNA_methylation1.92174685
22MP0001697_abnormal_embryo_size1.91061624
23MP0002080_prenatal_lethality1.87491012
24MP0003984_embryonic_growth_retardation1.86719706
25MP0002088_abnormal_embryonic_growth/wei1.82197509
26MP0001661_extended_life_span1.81566017
27MP0000490_abnormal_crypts_of1.73105866
28MP0004185_abnormal_adipocyte_glucose1.67678659
29MP0002089_abnormal_postnatal_growth/wei1.65542591
30MP0004808_abnormal_hematopoietic_stem1.65109639
31MP0002085_abnormal_embryonic_tissue1.63499405
32MP0000313_abnormal_cell_death1.60336857
33MP0003806_abnormal_nucleotide_metabolis1.59739212
34MP0002084_abnormal_developmental_patter1.58999703
35MP0002086_abnormal_extraembryonic_tissu1.57013762
36MP0009333_abnormal_splenocyte_physiolog1.50127795
37MP0002019_abnormal_tumor_incidence1.48755126
38MP0005257_abnormal_intraocular_pressure1.46437920
39MP0004197_abnormal_fetal_growth/weight/1.45804233
40MP0009697_abnormal_copulation1.44919942
41MP0000678_abnormal_parathyroid_gland1.43806861
42MP0003567_abnormal_fetal_cardiomyocyte1.39334935
43MP0003890_abnormal_embryonic-extraembry1.38009220
44MP0001545_abnormal_hematopoietic_system1.37102256
45MP0005397_hematopoietic_system_phenotyp1.37102256
46MP0000751_myopathy1.35617984
47MP0000358_abnormal_cell_content/1.32942603
48MP0002254_reproductive_system_inflammat1.28685132
49MP0001293_anophthalmia1.23434109
50MP0003315_abnormal_perineum_morphology1.23089048
51MP0002697_abnormal_eye_size1.22334565
52MP0001346_abnormal_lacrimal_gland1.20265310
53MP0000566_synostosis1.20231167
54MP0006292_abnormal_olfactory_placode1.18144541
55MP0005501_abnormal_skin_physiology1.18059764
56MP0003115_abnormal_respiratory_system1.16063151
57MP0002796_impaired_skin_barrier1.15349141
58MP0004272_abnormal_basement_membrane1.14409509
59MP0002210_abnormal_sex_determination1.13311605
60MP0002653_abnormal_ependyma_morphology1.12742793
61MP0003221_abnormal_cardiomyocyte_apopto1.11166965
62MP0000703_abnormal_thymus_morphology1.07850062
63MP0003121_genomic_imprinting1.07652514
64MP0009672_abnormal_birth_weight1.07285185
65MP0008260_abnormal_autophagy1.06347386
66MP0003119_abnormal_digestive_system1.06168392
67MP0001145_abnormal_male_reproductive1.04439614
68MP0002722_abnormal_immune_system1.02976900
69MP0008438_abnormal_cutaneous_collagen1.02413350
70MP0001348_abnormal_lacrimal_gland1.01711135
71MP0005076_abnormal_cell_differentiation1.01602126
72MP0002249_abnormal_larynx_morphology1.01477755
73MP0002398_abnormal_bone_marrow1.01023709
74MP0003763_abnormal_thymus_physiology1.00674056
75MP0003937_abnormal_limbs/digits/tail_de1.00453234
76MP0000689_abnormal_spleen_morphology0.98799859
77MP0005384_cellular_phenotype0.98139963
78MP0002160_abnormal_reproductive_system0.96411868
79MP0001299_abnormal_eye_distance/0.96292583
80MP0000762_abnormal_tongue_morphology0.96093501
81MP0003122_maternal_imprinting0.96047969
82MP0005075_abnormal_melanosome_morpholog0.95843309
83MP0006035_abnormal_mitochondrial_morpho0.94282852
84MP0000537_abnormal_urethra_morphology0.92617189
85MP0003385_abnormal_body_wall0.91602126
86MP0000747_muscle_weakness0.91343456
87MP0003942_abnormal_urinary_system0.89561006
88MP0000003_abnormal_adipose_tissue0.89342234
89MP0005621_abnormal_cell_physiology0.88913333
90MP0004133_heterotaxia0.88820651
91MP0005083_abnormal_biliary_tract0.87982524
92MP0001929_abnormal_gametogenesis0.85379632
93MP0002060_abnormal_skin_morphology0.84785143
94MP0000653_abnormal_sex_gland0.84228688
95MP0000858_altered_metastatic_potential0.83630129
96MP0000579_abnormal_nail_morphology0.81554890
97MP0002111_abnormal_tail_morphology0.81180615
98MP0002877_abnormal_melanocyte_morpholog0.80774850
99MP0010630_abnormal_cardiac_muscle0.79734963
100MP0002429_abnormal_blood_cell0.79587346
101MP0004087_abnormal_muscle_fiber0.79448668
102MP0005058_abnormal_lysosome_morphology0.79003943
103MP0003861_abnormal_nervous_system0.76650603
104MP0002233_abnormal_nose_morphology0.75082612
105MP0005330_cardiomyopathy0.74151670
106MP0005389_reproductive_system_phenotype0.73613793
107MP0000049_abnormal_middle_ear0.73364837
108MP0003943_abnormal_hepatobiliary_system0.71846633
109MP0002132_abnormal_respiratory_system0.71805628
110MP0009703_decreased_birth_body0.71348825
111MP0000759_abnormal_skeletal_muscle0.71089817
112MP0010030_abnormal_orbit_morphology0.70219448
113MP0000750_abnormal_muscle_regeneration0.68158170
114MP0006036_abnormal_mitochondrial_physio0.67646135
115MP0003186_abnormal_redox_activity0.66951137
116MP0001119_abnormal_female_reproductive0.66946762
117MP0000428_abnormal_craniofacial_morphol0.66264697
118MP0005266_abnormal_metabolism0.65257929
119MP0005023_abnormal_wound_healing0.64939025
120MP0000716_abnormal_immune_system0.62862622
121MP0008770_decreased_survivor_rate0.62830416
122MP0004233_abnormal_muscle_weight0.62680522
123MP0009278_abnormal_bone_marrow0.60849498
124MP0009053_abnormal_anal_canal0.60294355
125MP0000371_diluted_coat_color0.59580934
126MP0002269_muscular_atrophy0.59183305
127MP0003705_abnormal_hypodermis_morpholog0.59013063
128MP0002075_abnormal_coat/hair_pigmentati0.58717278
129MP0001915_intracranial_hemorrhage0.58210421
130MP0003566_abnormal_cell_adhesion0.57828009
131MP0000477_abnormal_intestine_morphology0.56551582
132MP0001853_heart_inflammation0.55771660
133MP0002092_abnormal_eye_morphology0.55440273
134MP0001849_ear_inflammation0.55291899
135MP0001919_abnormal_reproductive_system0.50211032
136MP0003699_abnormal_female_reproductive0.47245871
137MP0002095_abnormal_skin_pigmentation0.46543291
138MP0005395_other_phenotype0.45778959
139MP0004264_abnormal_extraembryonic_tissu0.44382287
140MP0003941_abnormal_skin_development0.44111998

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.33835706
2Microvesicular hepatic steatosis (HP:0001414)4.76755826
3Breast hypoplasia (HP:0003187)4.15270548
4Oral leukoplakia (HP:0002745)3.83008146
5Cerebral hypomyelination (HP:0006808)3.81534088
6Degeneration of anterior horn cells (HP:0002398)3.75569222
7Abnormality of the anterior horn cell (HP:0006802)3.75569222
8Rough bone trabeculation (HP:0100670)3.73313920
9Abnormality of cells of the erythroid lineage (HP:0012130)3.69020900
10Hyperacusis (HP:0010780)3.64080835
11Selective tooth agenesis (HP:0001592)3.62910470
12Abnormal number of erythroid precursors (HP:0012131)3.62741988
13Abnormality of glycolysis (HP:0004366)3.61300605
14Reticulocytopenia (HP:0001896)3.60419545
15Aplastic anemia (HP:0001915)3.58982822
16Ependymoma (HP:0002888)3.55407430
17Carpal bone hypoplasia (HP:0001498)3.54471126
18Colon cancer (HP:0003003)3.43015249
19Abnormal gallbladder physiology (HP:0012438)3.42985312
20Cholecystitis (HP:0001082)3.42985312
21Patellar aplasia (HP:0006443)3.37891995
22Aplasia/Hypoplasia of the patella (HP:0006498)3.26803263
23Insomnia (HP:0100785)3.26802135
24Increased serum pyruvate (HP:0003542)3.24258489
25Chromsome breakage (HP:0040012)3.24196288
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20742553
27Medulloblastoma (HP:0002885)3.06700194
28Ragged-red muscle fibers (HP:0003200)3.06421594
29Impulsivity (HP:0100710)3.03584952
30Meckel diverticulum (HP:0002245)2.94020402
31Abnormality of the preputium (HP:0100587)2.85991228
32Abnormality of the ileum (HP:0001549)2.81437074
33Abnormality of the labia minora (HP:0012880)2.80819327
34Progressive external ophthalmoplegia (HP:0000590)2.80647334
35Overriding aorta (HP:0002623)2.78576381
36Multiple enchondromatosis (HP:0005701)2.78568634
37Premature graying of hair (HP:0002216)2.76476619
38Agnosia (HP:0010524)2.74726436
39Abnormality of chromosome stability (HP:0003220)2.71018817
40Myelodysplasia (HP:0002863)2.67498651
41Renal duplication (HP:0000075)2.66096699
42Absent thumb (HP:0009777)2.65134990
43Premature ovarian failure (HP:0008209)2.64151471
44Deep venous thrombosis (HP:0002625)2.63674232
45Abnormal trabecular bone morphology (HP:0100671)2.62741976
46Microretrognathia (HP:0000308)2.62293059
47Absent radius (HP:0003974)2.61853890
48Bone marrow hypocellularity (HP:0005528)2.61624764
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.54930193
50Atrophy/Degeneration involving motor neurons (HP:0007373)2.54853635
51Trismus (HP:0000211)2.54448610
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.51248192
53Neoplasm of the pancreas (HP:0002894)2.50486642
54Upper limb amyotrophy (HP:0009129)2.49636072
55Distal upper limb amyotrophy (HP:0007149)2.49636072
56Rhabdomyosarcoma (HP:0002859)2.45555712
57Macrocytic anemia (HP:0001972)2.44886500
58Elfin facies (HP:0004428)2.44851364
59Aplasia involving forearm bones (HP:0009822)2.40170831
60Absent forearm bone (HP:0003953)2.40170831
61Progressive muscle weakness (HP:0003323)2.37073915
62Alacrima (HP:0000522)2.36528229
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35449762
64Basal cell carcinoma (HP:0002671)2.34689153
65Thrombocytosis (HP:0001894)2.33310357
66Cellular immunodeficiency (HP:0005374)2.31513993
67Tracheoesophageal fistula (HP:0002575)2.31320156
68Renovascular hypertension (HP:0100817)2.30583039
69Megaloblastic anemia (HP:0001889)2.30153391
70Small intestinal stenosis (HP:0012848)2.28506266
71Duodenal stenosis (HP:0100867)2.28506266
72Abnormality of the astrocytes (HP:0100707)2.27735881
73Astrocytoma (HP:0009592)2.27735881
74Ureteral duplication (HP:0000073)2.26017777
75CNS hypomyelination (HP:0003429)2.23766092
76Entropion (HP:0000621)2.23590995
77Abnormal number of incisors (HP:0011064)2.22955319
78Small epiphyses (HP:0010585)2.21158280
79Pallor (HP:0000980)2.19806271
80Sloping forehead (HP:0000340)2.18682259
8111 pairs of ribs (HP:0000878)2.18073822
82Squamous cell carcinoma (HP:0002860)2.16947632
83Orthostatic hypotension (HP:0001278)2.15349934
84Secondary amenorrhea (HP:0000869)2.14627620
85Spinal muscular atrophy (HP:0007269)2.14347625
86Hand muscle atrophy (HP:0009130)2.13761888
87Glioma (HP:0009733)2.13149625
88Glossoptosis (HP:0000162)2.12618976
89Horseshoe kidney (HP:0000085)2.10669974
90Tongue fasciculations (HP:0001308)2.10606451
91Testicular atrophy (HP:0000029)2.10133383
92Personality changes (HP:0000751)2.08380128
93Abnormality of the umbilical cord (HP:0010881)2.07571862
94Cleft eyelid (HP:0000625)2.06583989
95Prominent nose (HP:0000448)2.06073709
96Biconcave vertebral bodies (HP:0004586)2.05949480
97Postnatal microcephaly (HP:0005484)2.05806531
98Premature rupture of membranes (HP:0001788)2.05686978
99Vertebral compression fractures (HP:0002953)2.05555534
100Increased nuchal translucency (HP:0010880)2.04440931
101Slender long bone (HP:0003100)2.04410771
102Back pain (HP:0003418)2.03866733
103Abnormality of pain sensation (HP:0010832)2.03720450
104Impaired pain sensation (HP:0007328)2.03720450
105Increased connective tissue (HP:0009025)2.02892621
106Protrusio acetabuli (HP:0003179)2.01474597
107Achilles tendon contracture (HP:0001771)2.00579084
108Abnormality of reticulocytes (HP:0004312)2.00398878
109Asymmetry of the thorax (HP:0001555)2.00293914
110Abnormality of the carotid arteries (HP:0005344)1.99729483
111Amaurosis fugax (HP:0100576)1.98080654
112Pancytopenia (HP:0001876)1.95215009
113Reticulocytosis (HP:0001923)1.95154558
114Muscle fibrillation (HP:0010546)1.94425060
115Centrally nucleated skeletal muscle fibers (HP:0003687)1.94083557
116Proximal placement of thumb (HP:0009623)1.93260069
117Upper limb muscle weakness (HP:0003484)1.93106619
118Aplasia/hypoplasia of the humerus (HP:0006507)1.92842532
119Abnormality of the duodenum (HP:0002246)1.92005595
120Irregular epiphyses (HP:0010582)1.91809276
121Generalized hypotonia (HP:0001290)1.91522872
122Deviation of the thumb (HP:0009603)1.91254780
123Cafe-au-lait spot (HP:0000957)1.91236646
124Abnormality of pyrimidine metabolism (HP:0004353)1.89776967
125Supernumerary spleens (HP:0009799)1.88889137
126Premature skin wrinkling (HP:0100678)1.88864022
127Gout (HP:0001997)1.88672542
128Lymphoma (HP:0002665)1.88436948
129Facial hemangioma (HP:0000329)1.88435556
130Abnormality of DNA repair (HP:0003254)1.88334870
131Atresia of the external auditory canal (HP:0000413)1.87365812
132Abnormality of the Achilles tendon (HP:0005109)1.86858033
133Distal lower limb amyotrophy (HP:0008944)1.86410128
134Spastic diplegia (HP:0001264)1.84756796
135Generalized amyotrophy (HP:0003700)1.84514562
136Abnormal neuron morphology (HP:0012757)1.84086225
137Abnormality of the motor neurons (HP:0002450)1.84086225
138Abnormal lung lobation (HP:0002101)1.82550541
139Ankle contracture (HP:0006466)1.82057481
140Long palpebral fissure (HP:0000637)1.81941842
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81870629
142Absent epiphyses (HP:0010577)1.81870629
143Arnold-Chiari malformation (HP:0002308)1.81548231
144Sparse eyelashes (HP:0000653)1.81387385
145Decreased lacrimation (HP:0000633)1.79326392
146Short thumb (HP:0009778)1.78693378
147Broad distal phalanx of finger (HP:0009836)1.78544702
148Myopathic facies (HP:0002058)1.75070125
149Nephroblastoma (Wilms tumor) (HP:0002667)1.74502353
150Flat cornea (HP:0007720)1.71767223
151Ulnar bowing (HP:0003031)1.68778877
152Pointed chin (HP:0000307)1.66611136
153Cholelithiasis (HP:0001081)1.66480174
154Breech presentation (HP:0001623)1.65251380
155Shoulder girdle muscle weakness (HP:0003547)1.63869500
156Sensory axonal neuropathy (HP:0003390)1.63146715
157Type I transferrin isoform profile (HP:0003642)1.63061621
158Abnormality of carpal bone ossification (HP:0006257)1.62210778
159Embryonal renal neoplasm (HP:0011794)1.61856949
160Hypercholesterolemia (HP:0003124)1.60869291
161Cortical dysplasia (HP:0002539)1.58771895
162Gastrointestinal dysmotility (HP:0002579)1.58611097
163Impaired proprioception (HP:0010831)1.58448743
164Abnormality of skeletal muscle fiber size (HP:0012084)1.55624701
165Lower limb amyotrophy (HP:0007210)1.55453140
166Abnormality of the calcaneus (HP:0008364)1.54547126
167High anterior hairline (HP:0009890)1.54250087
168Increased variability in muscle fiber diameter (HP:0003557)1.53052699
169Progressive hearing impairment (HP:0001730)1.51834601
170Patellar dislocation (HP:0002999)1.51299685
171Distal lower limb muscle weakness (HP:0009053)1.50762137
172Microglossia (HP:0000171)1.50597776
173Broad alveolar ridges (HP:0000187)1.50522727
174Trigonocephaly (HP:0000243)1.50400632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.95656340
2WEE14.58327975
3TSSK63.61465786
4CDC73.56746047
5SMG13.40812093
6VRK23.18583136
7EIF2AK13.07986509
8NEK12.74708768
9ICK2.73776330
10STK162.70196052
11NEK22.64849224
12SRPK12.55557010
13NME22.30275668
14EIF2AK32.14220423
15TTK2.12339657
16FGFR42.02753538
17PLK12.00595060
18ACVR1B1.87243541
19BRSK21.86871778
20PBK1.82559466
21CDK71.75685819
22MKNK11.71133155
23EPHA21.66657402
24PLK31.66592056
25PLK41.61318949
26LIMK11.59824951
27TESK21.59549222
28PASK1.57807716
29EEF2K1.57111780
30VRK11.55455981
31ATR1.54629139
32BRSK11.54190673
33MKNK21.49029527
34IRAK31.47206061
35AURKB1.44262447
36CCNB11.41738200
37PRPF4B1.40927670
38PIM21.40078139
39CDK41.39312600
40SCYL21.38364717
41RPS6KB21.37172598
42CDK121.34698444
43AURKA1.30973884
44CHEK21.30087924
45MAP3K81.27126366
46LATS11.26639596
47DYRK31.25762560
48SIK11.22341766
49CHEK11.21677622
50ALK1.21626210
51RPS6KA41.21058579
52AKT31.18804063
53ERN11.15337487
54TGFBR11.14585836
55PDGFRA1.12947404
56MST1R1.09089930
57CLK11.04991830
58MAP3K110.98598271
59FLT30.98439101
60ZAK0.96761800
61PKN20.94040171
62PNCK0.91634111
63PAK40.91523200
64TAOK20.89935601
65CDK20.89649614
66MAP4K10.88228550
67TTN0.88024540
68NTRK10.86527321
69TLK10.84879731
70MAPK110.84697726
71BMX0.82463435
72STK100.81515450
73PIM10.80800276
74PAK10.75023991
75LATS20.73133170
76ERBB40.72287925
77CSNK2A20.72213415
78ATM0.70481550
79PRKD30.69885266
80ARAF0.68974390
81PRKCI0.68351998
82BRAF0.68047526
83PDK40.67618571
84PDK30.67618571
85EIF2AK20.66896608
86PTK60.66200021
87DAPK10.66103967
88PTK20.64735838
89BRD40.64525375
90CSNK2A10.61082750
91CDK90.59093801
92MAP2K30.58752859
93CDK10.57485284
94TAOK10.56081193
95LMTK20.55847897
96MAP3K60.55772661
97CDC42BPA0.55519719
98BCKDK0.55387123
99TAF10.54687415
100IRAK20.54397691
101MET0.53321194
102FGFR10.52675388
103STK40.51828591
104ZAP700.50621894
105AKT20.48325522
106CSNK1E0.46801081
107STK30.46018604
108TRIB30.45872276
109CDK80.45696289
110RAF10.45077479
111MTOR0.44837810
112MAP3K100.44748565
113CDK11A0.44102318
114STK38L0.43258385
115CDK150.42637073
116ILK0.42165147
117CDK180.40985847
118KDR0.37480929
119SIK30.37428319
120KSR20.37415629
121CAMK1D0.36928441
122MAPKAPK30.36580811
123LRRK20.35613119
124CDK140.33748862
125CDK60.31223411
126TESK10.30938680
127PDK20.30388899
128PAK20.28220977
129NME10.27034596
130MAP3K30.26491963
131MELK0.25731148
132GRK60.25359795
133PRKDC0.24088310
134KIT0.22627036
135BTK0.21416972
136RPS6KB10.21253072
137MAPK140.19572679
138MAP3K50.18889143
139CSF1R0.18736375

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.85489020
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.34449646
3Mismatch repair_Homo sapiens_hsa034304.04172474
4RNA polymerase_Homo sapiens_hsa030203.51650975
5Proteasome_Homo sapiens_hsa030503.47265581
6RNA transport_Homo sapiens_hsa030133.42612002
7Spliceosome_Homo sapiens_hsa030403.28240444
8Base excision repair_Homo sapiens_hsa034103.16854340
9Ribosome_Homo sapiens_hsa030103.00692221
10One carbon pool by folate_Homo sapiens_hsa006703.00008105
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.89879411
12Homologous recombination_Homo sapiens_hsa034402.82481800
13Nucleotide excision repair_Homo sapiens_hsa034202.78546502
14Cell cycle_Homo sapiens_hsa041102.54659172
15Pyrimidine metabolism_Homo sapiens_hsa002402.54269571
16Fanconi anemia pathway_Homo sapiens_hsa034601.96665574
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79753736
18Vitamin B6 metabolism_Homo sapiens_hsa007501.74080608
19RNA degradation_Homo sapiens_hsa030181.73910524
20mRNA surveillance pathway_Homo sapiens_hsa030151.71191203
21Basal transcription factors_Homo sapiens_hsa030221.66947653
22Non-homologous end-joining_Homo sapiens_hsa034501.61130175
23p53 signaling pathway_Homo sapiens_hsa041151.46362644
24Purine metabolism_Homo sapiens_hsa002301.40859078
25Biosynthesis of amino acids_Homo sapiens_hsa012301.37423650
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36143451
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.32055247
28Pyruvate metabolism_Homo sapiens_hsa006201.31257128
29Steroid biosynthesis_Homo sapiens_hsa001001.30151879
30Pentose phosphate pathway_Homo sapiens_hsa000301.28020249
31Epstein-Barr virus infection_Homo sapiens_hsa051691.25269879
32Fatty acid elongation_Homo sapiens_hsa000621.25008920
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.19507608
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14156439
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11459101
36Oocyte meiosis_Homo sapiens_hsa041141.08344538
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08036706
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01648683
39Folate biosynthesis_Homo sapiens_hsa007901.00841520
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97200293
41Antigen processing and presentation_Homo sapiens_hsa046120.92627025
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87931769
43Fructose and mannose metabolism_Homo sapiens_hsa000510.87413337
44Viral carcinogenesis_Homo sapiens_hsa052030.85836099
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.84374635
46Lysine degradation_Homo sapiens_hsa003100.82725453
47Selenocompound metabolism_Homo sapiens_hsa004500.82063749
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80991827
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80786596
50Sulfur relay system_Homo sapiens_hsa041220.80547461
51Herpes simplex infection_Homo sapiens_hsa051680.79336358
52Carbon metabolism_Homo sapiens_hsa012000.79175932
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79097624
54Systemic lupus erythematosus_Homo sapiens_hsa053220.66946466
55Thyroid cancer_Homo sapiens_hsa052160.66238098
56HTLV-I infection_Homo sapiens_hsa051660.66137885
57Regulation of autophagy_Homo sapiens_hsa041400.60517145
58Arginine biosynthesis_Homo sapiens_hsa002200.60105589
59Adherens junction_Homo sapiens_hsa045200.59946366
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58732476
61Legionellosis_Homo sapiens_hsa051340.56826550
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56489695
63Fatty acid metabolism_Homo sapiens_hsa012120.54578865
64Pancreatic cancer_Homo sapiens_hsa052120.53790519
65Galactose metabolism_Homo sapiens_hsa000520.48907270
66N-Glycan biosynthesis_Homo sapiens_hsa005100.45587402
67Insulin signaling pathway_Homo sapiens_hsa049100.44768394
68Wnt signaling pathway_Homo sapiens_hsa043100.44424149
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44047028
70Endometrial cancer_Homo sapiens_hsa052130.43135685
71Vibrio cholerae infection_Homo sapiens_hsa051100.40766628
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39576512
73HIF-1 signaling pathway_Homo sapiens_hsa040660.39396208
74MicroRNAs in cancer_Homo sapiens_hsa052060.39030264
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.38361324
76AMPK signaling pathway_Homo sapiens_hsa041520.37880488
77Apoptosis_Homo sapiens_hsa042100.37320482
78Small cell lung cancer_Homo sapiens_hsa052220.35981956
79Glucagon signaling pathway_Homo sapiens_hsa049220.35310978
80Glioma_Homo sapiens_hsa052140.34223272
81Hippo signaling pathway_Homo sapiens_hsa043900.33812089
82mTOR signaling pathway_Homo sapiens_hsa041500.33654442
83Other glycan degradation_Homo sapiens_hsa005110.33333311
84Colorectal cancer_Homo sapiens_hsa052100.31913698
85Prostate cancer_Homo sapiens_hsa052150.31423350
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30992364
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30826712
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29886612
89Proteoglycans in cancer_Homo sapiens_hsa052050.29875602
90Primary immunodeficiency_Homo sapiens_hsa053400.28554840
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28374518
92Phenylalanine metabolism_Homo sapiens_hsa003600.28026539
93Glutathione metabolism_Homo sapiens_hsa004800.27402547
94Tight junction_Homo sapiens_hsa045300.26642949
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25806164
96Shigellosis_Homo sapiens_hsa051310.25651771
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25387832
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25148519
99ErbB signaling pathway_Homo sapiens_hsa040120.24512619
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24401085
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23943809
102Bladder cancer_Homo sapiens_hsa052190.23822590
103Hepatitis B_Homo sapiens_hsa051610.23187581
104Acute myeloid leukemia_Homo sapiens_hsa052210.23022728
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23006984
106Chronic myeloid leukemia_Homo sapiens_hsa052200.22455813
107Measles_Homo sapiens_hsa051620.21959835
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20074561
109Notch signaling pathway_Homo sapiens_hsa043300.19338027
110Metabolic pathways_Homo sapiens_hsa011000.18195967
111Alcoholism_Homo sapiens_hsa050340.16002394
112TGF-beta signaling pathway_Homo sapiens_hsa043500.15011056
113Influenza A_Homo sapiens_hsa051640.14331744
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.13894905
115Non-small cell lung cancer_Homo sapiens_hsa052230.12760007
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12127100
117Huntingtons disease_Homo sapiens_hsa050160.11529107
118Pathways in cancer_Homo sapiens_hsa052000.09484301
119Basal cell carcinoma_Homo sapiens_hsa052170.08595032
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.08015499
121Vitamin digestion and absorption_Homo sapiens_hsa049770.07948148
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.07461976
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.06210043
124Renin-angiotensin system_Homo sapiens_hsa046140.05705967
125Arginine and proline metabolism_Homo sapiens_hsa003300.05395894
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04187769
127Hedgehog signaling pathway_Homo sapiens_hsa043400.02910015
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.02835314
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.02502515
130Type I diabetes mellitus_Homo sapiens_hsa049400.01892875

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