SMPD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.41594894
2DNA replication initiation (GO:0006270)4.38126024
3nuclear pore organization (GO:0006999)4.36414130
4proline biosynthetic process (GO:0006561)4.24280210
5DNA strand elongation involved in DNA replication (GO:0006271)4.22044842
6DNA unwinding involved in DNA replication (GO:0006268)4.20897580
7COPI coating of Golgi vesicle (GO:0048205)4.19400654
8Golgi transport vesicle coating (GO:0048200)4.19400654
9regulation of translational fidelity (GO:0006450)4.09519914
10protein localization to kinetochore (GO:0034501)4.09104294
11telomere maintenance via semi-conservative replication (GO:0032201)4.08054500
12regulation of nuclear cell cycle DNA replication (GO:0033262)4.02984727
13spliceosomal tri-snRNP complex assembly (GO:0000244)4.01878860
14DNA strand elongation (GO:0022616)4.01050407
15DNA replication checkpoint (GO:0000076)3.84118945
16kinetochore organization (GO:0051383)3.76501937
17regulation of mammary gland epithelial cell proliferation (GO:0033599)3.76469356
18DNA replication-dependent nucleosome assembly (GO:0006335)3.75217946
19DNA replication-dependent nucleosome organization (GO:0034723)3.75217946
20mitotic sister chromatid segregation (GO:0000070)3.73857119
21regulation of centriole replication (GO:0046599)3.73208544
22protein localization to chromosome, centromeric region (GO:0071459)3.72588357
23microtubule depolymerization (GO:0007019)3.71748185
24protein complex localization (GO:0031503)3.71319999
25telomere maintenance via recombination (GO:0000722)3.68870471
26pre-miRNA processing (GO:0031054)3.67320417
27mitotic metaphase plate congression (GO:0007080)3.61659694
28peptidyl-arginine omega-N-methylation (GO:0035247)3.61367111
29mitotic nuclear envelope disassembly (GO:0007077)3.60243566
30mitotic recombination (GO:0006312)3.58435019
31DNA topological change (GO:0006265)3.55350006
32cellular protein complex localization (GO:0034629)3.54178590
33chromosome condensation (GO:0030261)3.52426724
34kinetochore assembly (GO:0051382)3.51489894
35regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50944720
36regulation of histone H3-K9 methylation (GO:0051570)3.50711337
37negative regulation of DNA-dependent DNA replication (GO:2000104)3.49494839
38regulation of RNA export from nucleus (GO:0046831)3.47731377
39pore complex assembly (GO:0046931)3.47260247
40regulation of centrosome cycle (GO:0046605)3.42276195
41negative regulation of mRNA metabolic process (GO:1903312)3.41233382
42telomere maintenance via telomere lengthening (GO:0010833)3.40432528
43nucleobase biosynthetic process (GO:0046112)3.39872142
44DNA double-strand break processing (GO:0000729)3.38713943
45formation of translation preinitiation complex (GO:0001731)3.36755651
46protein K6-linked ubiquitination (GO:0085020)3.34557447
47sister chromatid segregation (GO:0000819)3.32264029
48positive regulation of chromosome segregation (GO:0051984)3.30640813
49chromatin remodeling at centromere (GO:0031055)3.28928953
50regulation of mitotic spindle organization (GO:0060236)3.28180973
51metaphase plate congression (GO:0051310)3.27994534
52membrane disassembly (GO:0030397)3.27626328
53nuclear envelope disassembly (GO:0051081)3.27626328
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.27513157
55mRNA stabilization (GO:0048255)3.26864515
56RNA stabilization (GO:0043489)3.26864515
57meiotic chromosome segregation (GO:0045132)3.26832204
58nucleosome disassembly (GO:0006337)3.25790442
59protein-DNA complex disassembly (GO:0032986)3.25790442
60mRNA splice site selection (GO:0006376)3.24296555
61mitotic sister chromatid cohesion (GO:0007064)3.23664901
62adherens junction assembly (GO:0034333)3.22989121
63DNA geometric change (GO:0032392)3.18931106
64DNA duplex unwinding (GO:0032508)3.18815853
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18237855
66CENP-A containing nucleosome assembly (GO:0034080)3.18125765
67negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.18100360
68DNA replication-independent nucleosome organization (GO:0034724)3.16899799
69DNA replication-independent nucleosome assembly (GO:0006336)3.16899799
70cell-substrate adherens junction assembly (GO:0007045)3.15359792
71focal adhesion assembly (GO:0048041)3.15359792
72proline metabolic process (GO:0006560)3.15006695
73regulation of histone H3-K27 methylation (GO:0061085)3.14093269
74regulation of helicase activity (GO:0051095)3.13110842
75apoptotic process involved in morphogenesis (GO:0060561)3.12868285
763-UTR-mediated mRNA stabilization (GO:0070935)3.11806671
77histone exchange (GO:0043486)3.11461320
78retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.10103234
79regulation of gene silencing by RNA (GO:0060966)3.09457722
80regulation of posttranscriptional gene silencing (GO:0060147)3.09457722
81regulation of gene silencing by miRNA (GO:0060964)3.09457722
82IMP biosynthetic process (GO:0006188)3.07584851
83regulation of nucleobase-containing compound transport (GO:0032239)3.07379276
84mismatch repair (GO:0006298)3.05870500
85planar cell polarity pathway involved in neural tube closure (GO:0090179)3.05655308
86DNA synthesis involved in DNA repair (GO:0000731)3.04046261
87regulation of telomere maintenance via telomerase (GO:0032210)3.03569624
88establishment of integrated proviral latency (GO:0075713)3.02539659
89maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00815152
90histone arginine methylation (GO:0034969)3.00566070
91protein retention in ER lumen (GO:0006621)2.99530511
92somatic hypermutation of immunoglobulin genes (GO:0016446)2.99255288
93somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99255288
94glucocorticoid receptor signaling pathway (GO:0042921)2.99217711
95negative regulation of mRNA processing (GO:0050686)2.98343448
96regulation of centrosome duplication (GO:0010824)2.97947016
97negative regulation of histone methylation (GO:0031061)2.96604557
98maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95534291
99ribosome biogenesis (GO:0042254)2.95353099
100DNA packaging (GO:0006323)2.95330900
101protein export from nucleus (GO:0006611)2.94925741
102regulation of chromosome segregation (GO:0051983)2.94802522
103peptidyl-arginine N-methylation (GO:0035246)2.93477726
104peptidyl-arginine methylation (GO:0018216)2.93477726
105negative regulation of chromosome segregation (GO:0051985)2.93276707
106nuclear envelope organization (GO:0006998)2.92540783
107ribosome assembly (GO:0042255)2.92502528
108activation of Rac GTPase activity (GO:0032863)2.91777058
109transcription-coupled nucleotide-excision repair (GO:0006283)2.90908660
110regulation of spindle organization (GO:0090224)2.90823517
111negative regulation of cell size (GO:0045792)2.90160948
112DNA conformation change (GO:0071103)2.87094630
113establishment of chromosome localization (GO:0051303)2.86942080
114DNA strand renaturation (GO:0000733)2.86873873
115histone H2A acetylation (GO:0043968)2.86794826
116negative regulation of mitotic sister chromatid separation (GO:2000816)2.86788612
117negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86788612
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86788612
119negative regulation of sister chromatid segregation (GO:0033046)2.86788612
120positive regulation of DNA-dependent DNA replication (GO:2000105)2.86788113
121intracellular estrogen receptor signaling pathway (GO:0030520)2.86368414
122pentose-phosphate shunt (GO:0006098)2.86038337
123mitotic chromosome condensation (GO:0007076)2.85881168
124spindle checkpoint (GO:0031577)2.85677837
125ATP-dependent chromatin remodeling (GO:0043044)2.84779417
126regulation of double-strand break repair via homologous recombination (GO:0010569)2.82382691
127rRNA transcription (GO:0009303)2.81446537
128purine nucleobase biosynthetic process (GO:0009113)2.80720433
129cellular response to epidermal growth factor stimulus (GO:0071364)2.79074578
130regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.78944911
131spliceosomal snRNP assembly (GO:0000387)2.78813961
132regulation of DNA-dependent DNA replication (GO:0090329)2.78790622
133mRNA splicing, via spliceosome (GO:0000398)2.77671855
134RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.77671855
135spindle assembly checkpoint (GO:0071173)2.77320409
136RNA splicing, via transesterification reactions (GO:0000375)2.77200229
137chromatin assembly or disassembly (GO:0006333)2.76911353
138termination of RNA polymerase II transcription (GO:0006369)2.76909306
139negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76882201
140regulation of DNA endoreduplication (GO:0032875)2.76731133
141mitotic G1 DNA damage checkpoint (GO:0031571)2.76572604
142regulation of translational termination (GO:0006449)2.76155183
143folic acid-containing compound biosynthetic process (GO:0009396)2.75454637
144heterochromatin organization (GO:0070828)2.74958031
145histone H3-K9 methylation (GO:0051567)2.74933366
146mitotic spindle checkpoint (GO:0071174)2.74783511
147regulation of NFAT protein import into nucleus (GO:0051532)2.74622813
148maternal placenta development (GO:0001893)2.73920135
149regulation of mitotic metaphase/anaphase transition (GO:0030071)2.73504280
150maturation of SSU-rRNA (GO:0030490)2.72919168
151negative regulation of RNA splicing (GO:0033119)2.72721971
152regulation of mitotic sister chromatid segregation (GO:0033047)2.71344371
153regulation of sister chromatid cohesion (GO:0007063)2.70964252
154chromatin assembly (GO:0031497)2.67645527
155ribosomal small subunit biogenesis (GO:0042274)2.65770665
156positive regulation of nuclease activity (GO:0032075)2.59963137
157NADPH regeneration (GO:0006740)2.59807854
158G1 DNA damage checkpoint (GO:0044783)2.57603170
159folic acid metabolic process (GO:0046655)2.57300926
160peptidyl-lysine dimethylation (GO:0018027)2.56335858
161positive regulation of cell cycle checkpoint (GO:1901978)2.55933429
162activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.53674559
163mRNA transport (GO:0051028)2.51750359
164protein maturation by protein folding (GO:0022417)2.51477041
165L-serine metabolic process (GO:0006563)2.51425171

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.04200713
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.33638047
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.74000835
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24257521
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.18312289
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10424792
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66796086
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57472703
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.46117518
10* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.36850246
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.36293032
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36189859
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33297042
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26923555
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.19305831
16ZNF263_19887448_ChIP-Seq_K562_Human2.18831650
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16707743
18VDR_21846776_ChIP-Seq_THP-1_Human2.15637579
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.11605914
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09583035
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.08312864
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.08312864
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.08312864
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06053532
25* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04040760
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01003908
27TP63_17297297_ChIP-ChIP_HaCaT_Human2.00927502
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00002459
29E2F7_22180533_ChIP-Seq_HELA_Human10.2209427
30* E2F1_21310950_ChIP-Seq_MCF-7_Human1.99093813
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97944973
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.96979622
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.94239291
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.92243661
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90662188
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89001767
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.88568174
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.87828580
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87679309
40XRN2_22483619_ChIP-Seq_HELA_Human1.86138976
41LXR_22292898_ChIP-Seq_THP-1_Human1.84951436
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83103713
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82521432
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79028191
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76828844
46AR_21909140_ChIP-Seq_LNCAP_Human1.72502986
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70295764
48RACK7_27058665_Chip-Seq_MCF-7_Human1.68951128
49CIITA_25753668_ChIP-Seq_RAJI_Human1.63411100
50VDR_23849224_ChIP-Seq_CD4+_Human1.61325337
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.61275316
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60053805
53TTF2_22483619_ChIP-Seq_HELA_Human1.59441802
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.58487122
55FOXP3_21729870_ChIP-Seq_TREG_Human1.57344851
56* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.57065244
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55986079
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55603108
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54198833
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51964982
61TCF7_22412390_ChIP-Seq_EML_Mouse1.50656838
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.47749646
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47590833
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45324413
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45291282
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44068469
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40267235
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40033551
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39529935
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39435925
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38851587
72KDM2B_26808549_Chip-Seq_DND41_Human1.37232869
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34047239
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31970819
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30936862
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30175784
77* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30043648
78CLOCK_20551151_ChIP-Seq_293T_Human1.29799564
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.27465981
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26752276
81GABP_19822575_ChIP-Seq_HepG2_Human1.24394097
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23733675
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23521925
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23143651
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22489533
86KDM5A_27292631_Chip-Seq_BREAST_Human1.21639092
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21637833
88P68_20966046_ChIP-Seq_HELA_Human1.19276364
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18178907
90DCP1A_22483619_ChIP-Seq_HELA_Human1.17240295
91KDM2B_26808549_Chip-Seq_K562_Human1.16231886
92ELK1_19687146_ChIP-ChIP_HELA_Human1.15634639
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.14937763
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14072913
95ATF3_27146783_Chip-Seq_COLON_Human1.13847966
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13475393
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13134495
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13042938
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12833200
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12257988
101NCOR1_26117541_ChIP-Seq_K562_Human1.11833488
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11097188
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09852571
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09403517
105* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08759217
106* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06751084
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06254376
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05797130
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04974520
110IRF1_19129219_ChIP-ChIP_H3396_Human1.04709410
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03854304
112CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03423490
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02786603
114SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02671324
115CREB1_26743006_Chip-Seq_LNCaP_Human1.02421748
116SA1_27219007_Chip-Seq_ERYTHROID_Human1.01981226
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01863652
118POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01476942
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00339947
120* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99393059
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99122138
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98867843
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97632683
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96856951
125SMC4_20622854_ChIP-Seq_HELA_Human0.96172860
126RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96038988
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.96002134
128EGR1_19374776_ChIP-ChIP_THP-1_Human0.95535425
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94653804
130EZH2_22144423_ChIP-Seq_EOC_Human0.93977265
131FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93925107
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93827763
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93184879
134NANOG_21062744_ChIP-ChIP_HESCs_Human0.92922761
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92351434
136SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89142959
137* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88068201
138ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87301409
139MYC_18940864_ChIP-ChIP_HL60_Human0.87298582
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87187961
141FUS_26573619_Chip-Seq_HEK293_Human0.86897967
142SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86887230
143NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86307815
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86094710
145SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85332898
146* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85086072
147ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84864043
148NANOG_16153702_ChIP-ChIP_HESCs_Human0.81173988
149KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80927848
150POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79561625
151MYC_22102868_ChIP-Seq_BL_Human0.78656986
152SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77974180
153GATA1_26923725_Chip-Seq_HPCs_Mouse0.76864877
154NOTCH1_21737748_ChIP-Seq_TLL_Human0.76347023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.47240165
2MP0003111_abnormal_nucleus_morphology4.33860428
3MP0010094_abnormal_chromosome_stability4.07087829
4MP0003705_abnormal_hypodermis_morpholog3.74291031
5MP0003693_abnormal_embryo_hatching3.69385293
6MP0003077_abnormal_cell_cycle3.29313326
7MP0004957_abnormal_blastocyst_morpholog3.22004944
8MP0008058_abnormal_DNA_repair3.04879784
9MP0008877_abnormal_DNA_methylation3.01920288
10MP0005076_abnormal_cell_differentiation2.96505367
11MP0005451_abnormal_body_composition2.70222625
12MP0008932_abnormal_embryonic_tissue2.38097714
13MP0006292_abnormal_olfactory_placode2.24012079
14MP0004133_heterotaxia2.21041948
15MP0002877_abnormal_melanocyte_morpholog2.15676703
16MP0001849_ear_inflammation2.13429890
17MP0004185_abnormal_adipocyte_glucose2.07212670
18MP0003566_abnormal_cell_adhesion2.06944128
19MP0008007_abnormal_cellular_replicative2.04886885
20MP0004233_abnormal_muscle_weight2.02525540
21MP0003136_yellow_coat_color1.92364079
22MP0003123_paternal_imprinting1.87304092
23MP0008260_abnormal_autophagy1.77408046
24MP0001730_embryonic_growth_arrest1.77165557
25MP0000350_abnormal_cell_proliferation1.75645492
26MP0004858_abnormal_nervous_system1.75605807
27MP0000678_abnormal_parathyroid_gland1.69665685
28MP0005410_abnormal_fertilization1.69180358
29MP0003890_abnormal_embryonic-extraembry1.68925689
30MP0001293_anophthalmia1.64250615
31MP0003121_genomic_imprinting1.61728788
32MP0002210_abnormal_sex_determination1.60535274
33MP0002653_abnormal_ependyma_morphology1.60309487
34MP0001929_abnormal_gametogenesis1.55344817
35MP0002085_abnormal_embryonic_tissue1.54723919
36MP0002089_abnormal_postnatal_growth/wei1.53895411
37MP0001672_abnormal_embryogenesis/_devel1.53722382
38MP0005380_embryogenesis_phenotype1.53722382
39MP0005058_abnormal_lysosome_morphology1.53320529
40MP0005257_abnormal_intraocular_pressure1.50790537
41MP0003786_premature_aging1.49214876
42MP0002102_abnormal_ear_morphology1.45712378
43MP0000003_abnormal_adipose_tissue1.45318902
44MP0003787_abnormal_imprinting1.45217635
45MP0002084_abnormal_developmental_patter1.43932586
46MP0000566_synostosis1.43816762
47MP0002396_abnormal_hematopoietic_system1.42547871
48MP0005501_abnormal_skin_physiology1.41165786
49MP0002796_impaired_skin_barrier1.40320640
50MP0003698_abnormal_male_reproductive1.40284240
51MP0001697_abnormal_embryo_size1.38505707
52MP0001145_abnormal_male_reproductive1.36278239
53MP0008438_abnormal_cutaneous_collagen1.36184260
54MP0001188_hyperpigmentation1.35650833
55MP0004264_abnormal_extraembryonic_tissu1.33336622
56MP0003941_abnormal_skin_development1.29917025
57MP0003937_abnormal_limbs/digits/tail_de1.28377422
58MP0003315_abnormal_perineum_morphology1.28249107
59MP0003119_abnormal_digestive_system1.27633162
60MP0003984_embryonic_growth_retardation1.27555539
61MP0003115_abnormal_respiratory_system1.26695933
62MP0010234_abnormal_vibrissa_follicle1.26362380
63MP0002160_abnormal_reproductive_system1.25077314
64MP0004272_abnormal_basement_membrane1.24620788
65MP0005621_abnormal_cell_physiology1.23832892
66MP0004197_abnormal_fetal_growth/weight/1.23822814
67MP0003861_abnormal_nervous_system1.23536540
68MP0003453_abnormal_keratinocyte_physiol1.22966501
69MP0009278_abnormal_bone_marrow1.22876630
70MP0002080_prenatal_lethality1.22313512
71MP0002088_abnormal_embryonic_growth/wei1.21419137
72MP0001348_abnormal_lacrimal_gland1.18038706
73MP0003938_abnormal_ear_development1.17784899
74MP0003567_abnormal_fetal_cardiomyocyte1.14616658
75MP0000653_abnormal_sex_gland1.14415277
76MP0001485_abnormal_pinna_reflex1.13361408
77MP0010030_abnormal_orbit_morphology1.12215202
78MP0000733_abnormal_muscle_development1.12203335
79MP0000313_abnormal_cell_death1.10361919
80MP0005666_abnormal_adipose_tissue1.10020513
81MP0010307_abnormal_tumor_latency1.07998752
82MP0000490_abnormal_crypts_of1.07905071
83MP0005377_hearing/vestibular/ear_phenot1.07334231
84MP0003878_abnormal_ear_physiology1.07334231
85MP0003942_abnormal_urinary_system1.06637161
86MP0001286_abnormal_eye_development1.06462172
87MP0002086_abnormal_extraembryonic_tissu1.05736959
88MP0003718_maternal_effect1.05482539
89MP0002249_abnormal_larynx_morphology1.05345015
90MP0002697_abnormal_eye_size1.04576563
91MP0005375_adipose_tissue_phenotype1.04237467
92MP0002060_abnormal_skin_morphology1.03526205
93MP0000537_abnormal_urethra_morphology1.02787499
94MP0004859_abnormal_synaptic_plasticity1.02294902
95MP0003091_abnormal_cell_migration1.01944009
96MP0009703_decreased_birth_body1.01803863
97MP0000049_abnormal_middle_ear0.98798329
98MP0001915_intracranial_hemorrhage0.97046372
99MP0001346_abnormal_lacrimal_gland0.93883845
100MP0008995_early_reproductive_senescence0.93298532
101MP0010630_abnormal_cardiac_muscle0.91948314
102MP0000462_abnormal_digestive_system0.90712289
103MP0001661_extended_life_span0.89037058
104MP0001986_abnormal_taste_sensitivity0.88071498
105MP0002161_abnormal_fertility/fecundity0.87721256
106MP0003755_abnormal_palate_morphology0.86093927
107MP0000432_abnormal_head_morphology0.84282488
108MP0000858_altered_metastatic_potential0.84101096
109MP0000751_myopathy0.83503526
110MP0002111_abnormal_tail_morphology0.83304272
111MP0005171_absent_coat_pigmentation0.82729130
112MP0005499_abnormal_olfactory_system0.82170962
113MP0005394_taste/olfaction_phenotype0.82170962
114MP0002751_abnormal_autonomic_nervous0.81724312
115MP0005409_darkened_coat_color0.80831680
116MP0005389_reproductive_system_phenotype0.80704414
117MP0002970_abnormal_white_adipose0.79646061
118MP0002114_abnormal_axial_skeleton0.79160170
119MP0009333_abnormal_splenocyte_physiolog0.79130898
120MP0009053_abnormal_anal_canal0.78503157
121MP0009931_abnormal_skin_appearance0.76701934
122MP0003943_abnormal_hepatobiliary_system0.76137938
123MP0001216_abnormal_epidermal_layer0.75917380
124MP0000703_abnormal_thymus_morphology0.75645741
125MP0002092_abnormal_eye_morphology0.75281349
126MP0002152_abnormal_brain_morphology0.75174396
127MP0000358_abnormal_cell_content/0.75168637
128MP0002938_white_spotting0.74874369
129MP0003935_abnormal_craniofacial_develop0.74874148
130MP0002019_abnormal_tumor_incidence0.73918026
131MP0000467_abnormal_esophagus_morphology0.73648141
132MP0005423_abnormal_somatic_nervous0.72791291
133MP0009672_abnormal_birth_weight0.71796105
134MP0005623_abnormal_meninges_morphology0.71750835
135MP0003172_abnormal_lysosome_physiology0.71207535
136MP0002925_abnormal_cardiovascular_devel0.69358011
137MP0000759_abnormal_skeletal_muscle0.69354982
138MP0010352_gastrointestinal_tract_polyps0.68988570
139MP0000762_abnormal_tongue_morphology0.68627184
140MP0001486_abnormal_startle_reflex0.66623191
141MP0003385_abnormal_body_wall0.66334876
142MP0002081_perinatal_lethality0.64229266
143MP0003880_abnormal_central_pattern0.63871098
144MP0008789_abnormal_olfactory_epithelium0.63662299
145MP0002116_abnormal_craniofacial_bone0.63147169
146MP0004808_abnormal_hematopoietic_stem0.62325946
147MP0000428_abnormal_craniofacial_morphol0.62031199
148MP0001119_abnormal_female_reproductive0.61870335
149MP0005384_cellular_phenotype0.61597338
150MP0005391_vision/eye_phenotype0.61536517
151MP0000778_abnormal_nervous_system0.61308210

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.53498189
2Chromsome breakage (HP:0040012)4.44853634
3Birth length less than 3rd percentile (HP:0003561)3.86332326
4Supernumerary spleens (HP:0009799)3.76356154
5Hyperacusis (HP:0010780)3.73823455
6Breast hypoplasia (HP:0003187)3.56186728
7Meckel diverticulum (HP:0002245)3.14788896
8Abnormality of the preputium (HP:0100587)3.03299047
9Abnormality of the labia minora (HP:0012880)3.01149136
10Abnormality of the ileum (HP:0001549)3.00987670
11Duplicated collecting system (HP:0000081)2.99519673
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.98454873
13Ependymoma (HP:0002888)2.97596098
14Ectopic kidney (HP:0000086)2.94940397
15Absent radius (HP:0003974)2.94648492
16Medulloblastoma (HP:0002885)2.93926055
17Abnormality of chromosome stability (HP:0003220)2.89992557
18Impulsivity (HP:0100710)2.84818474
19Ulnar bowing (HP:0003031)2.81378399
20Aplasia involving forearm bones (HP:0009822)2.78488251
21Absent forearm bone (HP:0003953)2.78488251
22Supernumerary bones of the axial skeleton (HP:0009144)2.77922986
23Abnormality of the renal collecting system (HP:0004742)2.73337251
24Asplenia (HP:0001746)2.67322748
25Abnormal number of incisors (HP:0011064)2.65462902
26Premature rupture of membranes (HP:0001788)2.64177897
27Protrusio acetabuli (HP:0003179)2.63117365
28Insomnia (HP:0100785)2.61963780
29Supernumerary ribs (HP:0005815)2.61805584
30Broad face (HP:0000283)2.59787540
31Disproportionate tall stature (HP:0001519)2.57575859
32Long palpebral fissure (HP:0000637)2.55820074
33Neoplasm of the oral cavity (HP:0100649)2.53878756
34Abdominal situs inversus (HP:0003363)2.53242486
35Abnormality of abdominal situs (HP:0011620)2.53242486
36Duodenal stenosis (HP:0100867)2.52639655
37Small intestinal stenosis (HP:0012848)2.52639655
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.52128619
39Abnormal lung lobation (HP:0002101)2.50982835
40Selective tooth agenesis (HP:0001592)2.50957013
41Patellar aplasia (HP:0006443)2.50131184
42Asymmetry of the thorax (HP:0001555)2.43686663
43Abnormal gallbladder physiology (HP:0012438)2.35793826
44Cholecystitis (HP:0001082)2.35793826
45Trismus (HP:0000211)2.33351043
46Aplasia/Hypoplasia of the patella (HP:0006498)2.32915579
47Deviation of the thumb (HP:0009603)2.32300422
48Broad distal phalanx of finger (HP:0009836)2.32158408
49Shallow orbits (HP:0000586)2.31556941
50Flat acetabular roof (HP:0003180)2.30644789
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29551349
52Progressive muscle weakness (HP:0003323)2.27769297
53Distal lower limb amyotrophy (HP:0008944)2.27317521
54Reticulocytosis (HP:0001923)2.26142457
55Abnormality of the carotid arteries (HP:0005344)2.25382581
56Glioma (HP:0009733)2.24250460
57Proximal placement of thumb (HP:0009623)2.22812531
58Achilles tendon contracture (HP:0001771)2.22579953
59Nephroblastoma (Wilms tumor) (HP:0002667)2.20569043
60Absent thumb (HP:0009777)2.20480444
61Microvesicular hepatic steatosis (HP:0001414)2.19797673
62Deep venous thrombosis (HP:0002625)2.19717672
63Myelodysplasia (HP:0002863)2.19274920
64Astrocytoma (HP:0009592)2.17701424
65Abnormality of the astrocytes (HP:0100707)2.17701424
66Biconcave vertebral bodies (HP:0004586)2.16319247
67Abnormal ventriculo-arterial connection (HP:0011563)2.15325866
68Transposition of the great arteries (HP:0001669)2.15325866
69Abnormal connection of the cardiac segments (HP:0011545)2.15325866
70Abnormality of DNA repair (HP:0003254)2.14962112
71Horseshoe kidney (HP:0000085)2.12004155
72Distal upper limb amyotrophy (HP:0007149)2.11868176
73Upper limb amyotrophy (HP:0009129)2.11868176
74Reticulocytopenia (HP:0001896)2.11523961
75Renal duplication (HP:0000075)2.11269877
76Abnormality of the duodenum (HP:0002246)2.10854790
77Sloping forehead (HP:0000340)2.09458808
78Small epiphyses (HP:0010585)2.08950178
79Cerebral hypomyelination (HP:0006808)2.08317671
80Advanced eruption of teeth (HP:0006288)2.06114731
81Homocystinuria (HP:0002156)2.05916487
82Abnormality of homocysteine metabolism (HP:0010919)2.05916487
83Septo-optic dysplasia (HP:0100842)2.04904369
84Colon cancer (HP:0003003)2.04738008
85Embryonal renal neoplasm (HP:0011794)2.04462778
86Volvulus (HP:0002580)2.04031977
87Increased nuchal translucency (HP:0010880)2.03935088
88Triphalangeal thumb (HP:0001199)2.02836594
89Abnormality of the Achilles tendon (HP:0005109)2.02606059
90Pointed chin (HP:0000307)2.00711897
91Agnosia (HP:0010524)2.00102459
92Premature skin wrinkling (HP:0100678)1.97464737
93Bone marrow hypocellularity (HP:0005528)1.96722831
94Short thumb (HP:0009778)1.95556150
95Natal tooth (HP:0000695)1.95404158
96Rhabdomyosarcoma (HP:0002859)1.95098883
97Rib fusion (HP:0000902)1.94492012
98Clubbing of toes (HP:0100760)1.94376555
99Urethral obstruction (HP:0000796)1.93779214
100Tracheoesophageal fistula (HP:0002575)1.93769052
101Duplication of thumb phalanx (HP:0009942)1.93615082
102Heterotopia (HP:0002282)1.93486960
103Esophageal atresia (HP:0002032)1.92729083
104Dysmetric saccades (HP:0000641)1.92433854
105Neoplasm of striated muscle (HP:0009728)1.92375895
106Abnormality of reticulocytes (HP:0004312)1.92337254
107Increased connective tissue (HP:0009025)1.92149830
108Abnormality of the fingertips (HP:0001211)1.91622835
109Abnormality of midbrain morphology (HP:0002418)1.90800435
110Molar tooth sign on MRI (HP:0002419)1.90800435
111Aplasia/Hypoplasia of the sternum (HP:0006714)1.90367597
112Facial cleft (HP:0002006)1.89786462
113Overlapping toe (HP:0001845)1.89748462
114Abnormality of the thoracic spine (HP:0100711)1.88877938
115Long eyelashes (HP:0000527)1.88624841
116Congenital malformation of the right heart (HP:0011723)1.87699917
117Double outlet right ventricle (HP:0001719)1.87699917
118Abnormality of the distal phalanx of the thumb (HP:0009617)1.86981280
119Deep palmar crease (HP:0006191)1.86471496
120Abnormality of the calcaneus (HP:0008364)1.85585981
121Abnormal respiratory epithelium morphology (HP:0012253)1.84892091
122Abnormal respiratory motile cilium morphology (HP:0005938)1.84892091
123Hemorrhage of the eye (HP:0011885)1.83813338
124Metaphyseal cupping (HP:0003021)1.83329486
125Ankyloglossia (HP:0010296)1.83162001
126Obstructive sleep apnea (HP:0002870)1.82607153
127Multiple enchondromatosis (HP:0005701)1.81737112
128Cerebral aneurysm (HP:0004944)1.81631344
129Aplasia/Hypoplasia of the earlobes (HP:0009906)1.81462599
130Overriding aorta (HP:0002623)1.81094613
131Hypoplastic pelvis (HP:0008839)1.80979302
132Adrenal hypoplasia (HP:0000835)1.80750855
133Trigonocephaly (HP:0000243)1.80345902
134Absent epiphyses (HP:0010577)1.79860914
135Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79860914
136Centrally nucleated skeletal muscle fibers (HP:0003687)1.78794414
137Breast aplasia (HP:0100783)1.78036079
138Aplasia/Hypoplasia of the breasts (HP:0010311)1.77882481
139Abnormal respiratory motile cilium physiology (HP:0012261)1.77796790
140High anterior hairline (HP:0009890)1.77623723
141Prominent nose (HP:0000448)1.77455243
142Anophthalmia (HP:0000528)1.77233191
143Tetralogy of Fallot (HP:0001636)1.77232406
144Thin ribs (HP:0000883)1.76482734
145Self-mutilation (HP:0000742)1.76190955
146Progressive external ophthalmoplegia (HP:0000590)1.75778959
147Vertebral compression fractures (HP:0002953)1.75008303
148Abnormality of the lower motor neuron (HP:0002366)1.74440771
149Pseudobulbar signs (HP:0002200)1.74248216
150Spinal rigidity (HP:0003306)1.74091486
151Microtia (HP:0008551)1.73554426
152Abnormality of the incisor (HP:0000676)1.72957482
153Dislocated radial head (HP:0003083)1.72392660
154Aplasia/hypoplasia of the humerus (HP:0006507)1.71439206
15511 pairs of ribs (HP:0000878)1.70934118
156Septate vagina (HP:0001153)1.70277541
157Sparse lateral eyebrow (HP:0005338)1.69774375
158Premature graying of hair (HP:0002216)1.69352740
159Elfin facies (HP:0004428)1.68930624
160Patellar dislocation (HP:0002999)1.68215029
161Carpal bone hypoplasia (HP:0001498)1.67769342
162Rough bone trabeculation (HP:0100670)1.67637133
163Absent/shortened dynein arms (HP:0200106)1.67607527
164Dynein arm defect of respiratory motile cilia (HP:0012255)1.67607527
165Broad palm (HP:0001169)1.66186367
166Preaxial hand polydactyly (HP:0001177)1.65971642
167Ankle contracture (HP:0006466)1.65471824
168Cleft eyelid (HP:0000625)1.65057046
169Limited elbow extension (HP:0001377)1.64993011
170Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64845792
171Arnold-Chiari malformation (HP:0002308)1.64831153
172Flattened epiphyses (HP:0003071)1.64257906
173Squamous cell carcinoma (HP:0002860)1.64073530
174Abnormality of oral frenula (HP:0000190)1.62913294
175Ragged-red muscle fibers (HP:0003200)1.62797606
176Glossoptosis (HP:0000162)1.62215905
177Abnormality of the umbilical cord (HP:0010881)1.61834385
178Mitral regurgitation (HP:0001653)1.61707223
179Stridor (HP:0010307)1.61521030
180Lower limb amyotrophy (HP:0007210)1.61327801
181Turricephaly (HP:0000262)1.61098303
182Abnormality of the radial head (HP:0003995)1.60186686
183Preauricular skin tag (HP:0000384)1.59767377
184Vertebral arch anomaly (HP:0008438)1.59708665
185Atresia of the external auditory canal (HP:0000413)1.57732207
186Cervical subluxation (HP:0003308)1.56218613
187Skull defect (HP:0001362)1.55867707
188Back pain (HP:0003418)1.55698105
189Nonimmune hydrops fetalis (HP:0001790)1.53703768
190Abnormality of the salivary glands (HP:0010286)1.53271281
191Abnormal foot bone ossification (HP:0010675)1.52492185
192Abnormal ossification of hand bones (HP:0005921)1.52377173
193Poikiloderma (HP:0001029)1.52204391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.39543510
2CDC74.20758272
3SMG14.07066963
4CDK123.75649451
5BUB13.58944393
6WEE13.38930833
7TTK3.38116614
8SRPK13.25728014
9EEF2K3.21518639
10BRD42.72482357
11SIK12.68754002
12PNCK2.52492513
13MAP3K102.51812434
14MKNK12.40173385
15NEK22.22826884
16MKNK22.12196958
17FGFR42.12119208
18IRAK32.12049358
19ZAK2.07185706
20ICK2.03769253
21CDK72.01493082
22PLK41.98759341
23CLK11.97684478
24TSSK61.97498934
25PLK11.94528320
26ATR1.86669163
27EIF2AK11.84314036
28CHEK21.81463659
29TLK11.73739993
30PLK31.68121007
31ERN11.67346514
32VRK11.57344628
33CHEK11.55232352
34PKN21.44498969
35STK161.41866007
36PDGFRA1.41501814
37RIPK11.36352778
38TNIK1.35461528
39CDK41.35194317
40MST1R1.34641674
41PASK1.33298390
42STK41.31967007
43EPHA21.30416446
44TTN1.29084525
45DYRK31.23798578
46AURKA1.23500125
47AURKB1.23295314
48ATM1.19610678
49CDK21.13186760
50SCYL21.11406626
51AKT31.09750929
52NTRK31.08433769
53BRSK11.01861662
54RPS6KB21.01406518
55PTK21.00222573
56EIF2AK30.94829722
57ALK0.93738538
58CDK10.93191014
59VRK20.90344821
60MAPK110.89435434
61MAP2K30.88150861
62EPHA40.87809036
63MAP3K80.86293264
64BRSK20.85364816
65SIK20.83781228
66KSR20.81774688
67NEK60.81191756
68TESK20.79574715
69SIK30.79524233
70CSNK1E0.78531062
71PBK0.78175050
72BMX0.77622572
73PRPF4B0.77447474
74PTK60.76129546
75NTRK20.72245860
76CSNK2A20.70807421
77MET0.70400170
78YES10.70056808
79BRAF0.69416273
80TESK10.65811577
81CSNK1D0.62298529
82CSNK1A1L0.61195152
83MELK0.61131752
84GSK3B0.61038257
85PRKCI0.60766406
86PRKD20.59589285
87CDC42BPA0.59054989
88PAK20.58593037
89CDK60.57969771
90PRKDC0.57675526
91CAMK1D0.56996567
92CDK30.55101845
93MAPK140.54962172
94STK30.54743903
95TYRO30.49908813
96MAP3K130.49793098
97MAP2K20.49445043
98CCNB10.49233859
99PAK10.48448197
100EIF2AK20.48279403
101UHMK10.48016905
102CSNK1G30.46928255
103RPS6KA20.46864563
104BCR0.46634565
105RPS6KC10.46332783
106RPS6KL10.46332783
107RPS6KA50.46166088
108TAOK20.45533151
109ARAF0.45522478
110LATS20.45438866
111STK38L0.45353104
112NME10.43326948
113CSNK2A10.42508733
114MTOR0.42419942
115CDK90.40463342
116MAP3K90.40456813
117PDPK10.40074547
118CDK11A0.39634364
119PIM20.38839672
120IRAK20.38744077
121PIM10.38607967
122STK100.37842700
123PRKD30.37292649
124CAMK1G0.36924123
125KSR10.36690938
126DYRK1A0.36603323
127DMPK0.36442389
128AKT20.36420646
129CDK80.36315009
130RPS6KA10.36242442
131MARK20.36195138
132CDK150.36174720
133RET0.35543529
134LATS10.35408552
135CDK180.35386713
136KDR0.35198789
137LRRK20.34737976
138LMTK20.34710068
139MAPK100.33790290
140CSNK1G20.33103407
141CSNK1G10.32276859
142AKT10.31094864
143MAPK80.30574822
144NEK10.29873214
145MAPK10.29444166
146TNK20.28071852
147NME20.27573954
148PAK40.27368540
149RPS6KB10.27199397
150PLK20.24397855

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.64139387
2Mismatch repair_Homo sapiens_hsa034304.23072449
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.59811272
4Homologous recombination_Homo sapiens_hsa034403.50979484
5Spliceosome_Homo sapiens_hsa030403.33898867
6Fanconi anemia pathway_Homo sapiens_hsa034603.15713361
7RNA polymerase_Homo sapiens_hsa030202.99061789
8RNA transport_Homo sapiens_hsa030132.98998293
9Nucleotide excision repair_Homo sapiens_hsa034202.87744141
10Base excision repair_Homo sapiens_hsa034102.81782243
11Cell cycle_Homo sapiens_hsa041102.57127288
12mRNA surveillance pathway_Homo sapiens_hsa030152.42270955
13One carbon pool by folate_Homo sapiens_hsa006702.38498580
14Basal transcription factors_Homo sapiens_hsa030222.22138449
15Biosynthesis of amino acids_Homo sapiens_hsa012302.13911420
16Non-homologous end-joining_Homo sapiens_hsa034502.09939517
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09179308
18Pyrimidine metabolism_Homo sapiens_hsa002402.07692912
19RNA degradation_Homo sapiens_hsa030182.03484106
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.89913497
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83599084
22Ribosome_Homo sapiens_hsa030101.79201252
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76530868
24Bladder cancer_Homo sapiens_hsa052191.74772896
25Pentose phosphate pathway_Homo sapiens_hsa000301.72395186
26Proteasome_Homo sapiens_hsa030501.60352331
27Fructose and mannose metabolism_Homo sapiens_hsa000511.59673160
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45070181
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43145899
30Sulfur relay system_Homo sapiens_hsa041221.39369663
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37241157
32Oocyte meiosis_Homo sapiens_hsa041141.33657902
33p53 signaling pathway_Homo sapiens_hsa041151.32482233
34Carbon metabolism_Homo sapiens_hsa012001.31716828
35Pancreatic cancer_Homo sapiens_hsa052121.30134254
36Purine metabolism_Homo sapiens_hsa002301.27518208
37Other glycan degradation_Homo sapiens_hsa005111.22610440
38Endometrial cancer_Homo sapiens_hsa052131.21925047
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21864427
40Systemic lupus erythematosus_Homo sapiens_hsa053221.18746969
41Vitamin B6 metabolism_Homo sapiens_hsa007501.04020135
42N-Glycan biosynthesis_Homo sapiens_hsa005101.03061659
43Galactose metabolism_Homo sapiens_hsa000521.01910185
44Basal cell carcinoma_Homo sapiens_hsa052171.01295648
45Nicotine addiction_Homo sapiens_hsa050330.99523493
46VEGF signaling pathway_Homo sapiens_hsa043700.98894029
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98154126
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96624269
49Glioma_Homo sapiens_hsa052140.96320976
50Epstein-Barr virus infection_Homo sapiens_hsa051690.93812793
51Insulin signaling pathway_Homo sapiens_hsa049100.93125198
52Prion diseases_Homo sapiens_hsa050200.93038637
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91585495
54AMPK signaling pathway_Homo sapiens_hsa041520.89032836
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86694047
56Hedgehog signaling pathway_Homo sapiens_hsa043400.86398363
57mTOR signaling pathway_Homo sapiens_hsa041500.85589988
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84248206
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82799513
60Alcoholism_Homo sapiens_hsa050340.81286632
61Renal cell carcinoma_Homo sapiens_hsa052110.80632982
62Herpes simplex infection_Homo sapiens_hsa051680.79203252
63Proteoglycans in cancer_Homo sapiens_hsa052050.78889499
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.77195677
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75473790
66MicroRNAs in cancer_Homo sapiens_hsa052060.73498825
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73162212
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73076075
69Viral carcinogenesis_Homo sapiens_hsa052030.72896938
70Hippo signaling pathway_Homo sapiens_hsa043900.70698731
71HTLV-I infection_Homo sapiens_hsa051660.67988223
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66753656
73Focal adhesion_Homo sapiens_hsa045100.66170751
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64079809
75Shigellosis_Homo sapiens_hsa051310.62453825
76Wnt signaling pathway_Homo sapiens_hsa043100.61366862
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60208481
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59149031
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58326562
80Notch signaling pathway_Homo sapiens_hsa043300.56600403
81Arginine biosynthesis_Homo sapiens_hsa002200.54339560
82Pyruvate metabolism_Homo sapiens_hsa006200.51723665
83Lysine degradation_Homo sapiens_hsa003100.51350307
84HIF-1 signaling pathway_Homo sapiens_hsa040660.51228608
85Glutamatergic synapse_Homo sapiens_hsa047240.51114959
86Long-term potentiation_Homo sapiens_hsa047200.49802145
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49447665
88B cell receptor signaling pathway_Homo sapiens_hsa046620.49327883
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47959882
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47822334
91Glucagon signaling pathway_Homo sapiens_hsa049220.46711198
92Colorectal cancer_Homo sapiens_hsa052100.46634767
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.46342430
94Ether lipid metabolism_Homo sapiens_hsa005650.45762771
95Axon guidance_Homo sapiens_hsa043600.45719609
96Linoleic acid metabolism_Homo sapiens_hsa005910.45623299
97Thyroid cancer_Homo sapiens_hsa052160.44888887
98TGF-beta signaling pathway_Homo sapiens_hsa043500.44442918
99Long-term depression_Homo sapiens_hsa047300.43954322
100Taste transduction_Homo sapiens_hsa047420.42423051
101Folate biosynthesis_Homo sapiens_hsa007900.42389887
102Huntingtons disease_Homo sapiens_hsa050160.41195445
103Arginine and proline metabolism_Homo sapiens_hsa003300.40254124
104Hepatitis C_Homo sapiens_hsa051600.40054974
105Choline metabolism in cancer_Homo sapiens_hsa052310.39263068
106Dorso-ventral axis formation_Homo sapiens_hsa043200.39150479
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38872642
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38109979
109Amphetamine addiction_Homo sapiens_hsa050310.37503491
110Arachidonic acid metabolism_Homo sapiens_hsa005900.37277536
111Pathways in cancer_Homo sapiens_hsa052000.37261077
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36035342
113Prostate cancer_Homo sapiens_hsa052150.32119072
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31290774
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30755064
116Tight junction_Homo sapiens_hsa045300.29555836
117Adherens junction_Homo sapiens_hsa045200.29274785
118Autoimmune thyroid disease_Homo sapiens_hsa053200.29235196
119Melanoma_Homo sapiens_hsa052180.28329858
120MAPK signaling pathway_Homo sapiens_hsa040100.26780253
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26566056
122Serotonergic synapse_Homo sapiens_hsa047260.26533153
123Small cell lung cancer_Homo sapiens_hsa052220.25265484
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.25114773
125Inositol phosphate metabolism_Homo sapiens_hsa005620.23337018
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.23169547
127Phototransduction_Homo sapiens_hsa047440.22248800
128Non-small cell lung cancer_Homo sapiens_hsa052230.21637684
129Melanogenesis_Homo sapiens_hsa049160.21125179
130Circadian entrainment_Homo sapiens_hsa047130.20570213
131Primary immunodeficiency_Homo sapiens_hsa053400.19741903
132ErbB signaling pathway_Homo sapiens_hsa040120.18954391
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.18153789
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18103494
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17979071
136Calcium signaling pathway_Homo sapiens_hsa040200.17741261
137Hepatitis B_Homo sapiens_hsa051610.16855492
138Acute myeloid leukemia_Homo sapiens_hsa052210.16481516
139Morphine addiction_Homo sapiens_hsa050320.15869067
140Chronic myeloid leukemia_Homo sapiens_hsa052200.13738942
141Dopaminergic synapse_Homo sapiens_hsa047280.12561527
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11871474
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11615716
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11184180
145Antigen processing and presentation_Homo sapiens_hsa046120.10997523
146Apoptosis_Homo sapiens_hsa042100.09877543
147Estrogen signaling pathway_Homo sapiens_hsa049150.09025856

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