SMPD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.51477561
2regulation of guanylate cyclase activity (GO:0031282)5.13574328
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.12986544
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.09351339
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.02044414
6locomotory exploration behavior (GO:0035641)4.77888844
7angiotensin maturation (GO:0002003)4.77161251
8synaptic vesicle maturation (GO:0016188)4.69857323
9regulation of synapse structural plasticity (GO:0051823)4.68070303
10layer formation in cerebral cortex (GO:0021819)4.67339752
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.67315236
12regulation of glutamate receptor signaling pathway (GO:1900449)4.64196306
13behavioral response to nicotine (GO:0035095)4.60360133
14dendritic spine morphogenesis (GO:0060997)4.53466850
15neuron cell-cell adhesion (GO:0007158)4.50524606
16protein localization to synapse (GO:0035418)4.49023281
17cilium or flagellum-dependent cell motility (GO:0001539)4.46737517
18exploration behavior (GO:0035640)4.31002226
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.20759205
20synaptic vesicle exocytosis (GO:0016079)4.20168176
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.11470246
22axonemal dynein complex assembly (GO:0070286)4.03463041
23regulation of neuronal synaptic plasticity (GO:0048168)4.02052647
24positive regulation of guanylate cyclase activity (GO:0031284)4.00105030
25regulation of synaptic vesicle exocytosis (GO:2000300)3.99322177
26glutamate secretion (GO:0014047)3.86874658
27regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.86859632
28auditory behavior (GO:0031223)3.85786812
29pyrimidine nucleobase catabolic process (GO:0006208)3.83557210
30neurotransmitter-gated ion channel clustering (GO:0072578)3.82816418
31neuron recognition (GO:0008038)3.81222551
32regulation of dendritic spine morphogenesis (GO:0061001)3.77397686
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.75573352
34proline transport (GO:0015824)3.68503735
35alkaloid metabolic process (GO:0009820)3.66308308
36glutamate receptor signaling pathway (GO:0007215)3.66046972
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.63393317
38neurotransmitter secretion (GO:0007269)3.61298692
39synaptic transmission, glutamatergic (GO:0035249)3.59394148
40axonal fasciculation (GO:0007413)3.55609813
41regulation of synaptic vesicle transport (GO:1902803)3.53594043
42cilium movement (GO:0003341)3.52742436
43adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.52302027
44neuron-neuron synaptic transmission (GO:0007270)3.51280181
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.49266033
46phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.48768579
47dendrite morphogenesis (GO:0048813)3.47919619
48positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.45311105
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45081396
50prepulse inhibition (GO:0060134)3.44574200
51dopamine receptor signaling pathway (GO:0007212)3.40898219
52transmission of nerve impulse (GO:0019226)3.39370354
53gamma-aminobutyric acid transport (GO:0015812)3.37489961
54cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.37345246
55transepithelial transport (GO:0070633)3.36359952
56receptor guanylyl cyclase signaling pathway (GO:0007168)3.36166510
57positive regulation of synapse maturation (GO:0090129)3.36012974
58nucleobase catabolic process (GO:0046113)3.35733521
59postsynaptic membrane organization (GO:0001941)3.34510219
60long-term memory (GO:0007616)3.34315871
61response to auditory stimulus (GO:0010996)3.33861098
62positive regulation of membrane potential (GO:0045838)3.32412271
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27798933
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27474000
65dendritic spine organization (GO:0097061)3.26394139
66regulation of postsynaptic membrane potential (GO:0060078)3.25529613
67regulation of dendritic spine development (GO:0060998)3.22948120
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22718147
69central nervous system projection neuron axonogenesis (GO:0021952)3.19466928
70G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.18653262
71neuromuscular process controlling balance (GO:0050885)3.18200349
72epoxygenase P450 pathway (GO:0019373)3.16062298
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.15961276
74regulation of synaptic plasticity (GO:0048167)3.15886061
75positive regulation of neurotransmitter secretion (GO:0001956)3.14658538
76regulation of vesicle fusion (GO:0031338)3.13245866
77positive regulation of dendritic spine morphogenesis (GO:0061003)3.13197307
78positive regulation of dendritic spine development (GO:0060999)3.12794249
79cell aggregation (GO:0098743)3.11494356
80cartilage condensation (GO:0001502)3.11494356
81positive regulation of neurotransmitter transport (GO:0051590)3.11365983
82regulation of female receptivity (GO:0045924)3.10092964
83regulation of cGMP biosynthetic process (GO:0030826)3.07271591
84epithelial cilium movement (GO:0003351)3.06681173
85synapse assembly (GO:0007416)3.04043200
86vitamin transmembrane transport (GO:0035461)3.02446987
87neuronal action potential propagation (GO:0019227)3.01851038
88axoneme assembly (GO:0035082)3.00116255
89behavioral fear response (GO:0001662)3.00038605
90behavioral defense response (GO:0002209)3.00038605
91synaptic transmission, dopaminergic (GO:0001963)2.98666802
92limb bud formation (GO:0060174)2.97997797
93cell migration in hindbrain (GO:0021535)2.96896029
94response to histamine (GO:0034776)2.95977142
95regulation of neurotransmitter secretion (GO:0046928)2.95104766
96long-term synaptic potentiation (GO:0060291)2.94781235
97learning (GO:0007612)2.93910574
98chondrocyte development (GO:0002063)2.93271216
99activation of protein kinase A activity (GO:0034199)2.92681847
100mechanosensory behavior (GO:0007638)2.92394505
101intestinal absorption (GO:0050892)2.92317526
102response to amphetamine (GO:0001975)2.92157386
103motile cilium assembly (GO:0044458)2.91483814
104fat-soluble vitamin biosynthetic process (GO:0042362)2.90533357
105diacylglycerol metabolic process (GO:0046339)2.90499333
106lipoprotein transport (GO:0042953)2.87444092
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86554215
108behavioral response to cocaine (GO:0048148)2.86173061
109positive regulation of respiratory burst (GO:0060267)2.85350379
110positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.84279178
111neurotransmitter transport (GO:0006836)2.84253178
112positive regulation of vesicle fusion (GO:0031340)2.82329599
113presynaptic membrane assembly (GO:0097105)2.80879226
114membrane hyperpolarization (GO:0060081)2.80280299
115cAMP catabolic process (GO:0006198)2.80171754
116female mating behavior (GO:0060180)2.80019917
117negative regulation of dendrite development (GO:2000171)2.79620291
118regulation of neurotransmitter transport (GO:0051588)2.79389121
119neuronal ion channel clustering (GO:0045161)2.79239778
120regulation of cellular extravasation (GO:0002691)2.78164505
121fear response (GO:0042596)2.77131338
122drug catabolic process (GO:0042737)2.76470273
123exogenous drug catabolic process (GO:0042738)2.76464493
124membrane depolarization (GO:0051899)2.76044574
125innervation (GO:0060384)2.75758912
126cellular potassium ion homeostasis (GO:0030007)2.75716684
127glycine transport (GO:0015816)2.74545742
128striatum development (GO:0021756)2.72529906
129regulation of triglyceride catabolic process (GO:0010896)2.70933966
130regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.67539061
131endocrine process (GO:0050886)2.67539061
132regulation of systemic arterial blood pressure by hormone (GO:0001990)2.67539061
133drug metabolic process (GO:0017144)2.63722687
134regulation of systemic arterial blood pressure (GO:0003073)2.57476096
135sodium ion homeostasis (GO:0055078)2.51042041
136maintenance of gastrointestinal epithelium (GO:0030277)2.49537382
137digestion (GO:0007586)2.49532786
138sulfate transmembrane transport (GO:1902358)2.49330444
139sensory perception of taste (GO:0050909)2.47632350
140hormone catabolic process (GO:0042447)2.45699882
141neurotransmitter metabolic process (GO:0042133)2.45489869
142bile acid and bile salt transport (GO:0015721)2.44927993
143neuromuscular synaptic transmission (GO:0007274)2.44546972
144regulation of cGMP metabolic process (GO:0030823)2.44458925
145neurotransmitter biosynthetic process (GO:0042136)2.43769501
146neuronal action potential (GO:0019228)2.42262474
1473-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.39366022
148purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.39366022
149phosphatidylserine acyl-chain remodeling (GO:0036150)2.39333522
150sodium ion transmembrane transport (GO:0035725)2.36337694
151neurotransmitter catabolic process (GO:0042135)2.36256155
152calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.31666649
153regulation of bile acid biosynthetic process (GO:0070857)2.30217979
154synaptic transmission, cholinergic (GO:0007271)2.29707888
155sodium ion transport (GO:0006814)2.27040634
156sulfur compound transport (GO:0072348)2.26517231
157positive regulation of cGMP biosynthetic process (GO:0030828)2.26467979
158serotonin metabolic process (GO:0042428)2.26091438
159fucose catabolic process (GO:0019317)2.25966682
160L-fucose metabolic process (GO:0042354)2.25966682
161L-fucose catabolic process (GO:0042355)2.25966682
162regulation of microtubule-based movement (GO:0060632)2.25413112
163sialylation (GO:0097503)2.25163084
164regulation of synapse maturation (GO:0090128)2.25003063
165peptide hormone processing (GO:0016486)2.24775647
166phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.23807714
167presynaptic membrane organization (GO:0097090)2.22973750
168detection of light stimulus involved in sensory perception (GO:0050962)2.22834519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08857864
2GBX2_23144817_ChIP-Seq_PC3_Human3.27127288
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05598868
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03715638
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88560332
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.81674340
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72991412
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70077591
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70077591
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60961469
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58918505
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50984018
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47544518
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40237071
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.37052386
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.35754471
17AR_21572438_ChIP-Seq_LNCaP_Human2.33334762
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30116676
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.29676456
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.25704105
21* RARB_27405468_Chip-Seq_BRAIN_Mouse2.24484275
22DROSHA_22980978_ChIP-Seq_HELA_Human2.22909434
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02205378
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00622363
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98059431
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.95203347
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.83193152
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.80734679
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79633769
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79596543
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.78801450
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77099511
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72231359
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69061479
35PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.61297488
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.55221233
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.52336330
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51155314
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48200111
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47429750
41P68_20966046_ChIP-Seq_HELA_Human1.45903028
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45065112
43BCL6_27268052_Chip-Seq_Bcells_Human1.44771376
44E2F1_20622854_ChIP-Seq_HELA_Human1.42681194
45SMAD4_21799915_ChIP-Seq_A2780_Human1.42310884
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42062892
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.42038898
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.41806757
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41045225
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.40176733
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39013356
52LXR_22292898_ChIP-Seq_THP-1_Human1.37810310
53BCOR_27268052_Chip-Seq_Bcells_Human1.37563401
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37442722
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36758319
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36261726
57TAF15_26573619_Chip-Seq_HEK293_Human1.35411013
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31865445
59PHF8_20622854_ChIP-Seq_HELA_Human1.30664353
60* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30003068
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29262648
62ZNF274_21170338_ChIP-Seq_K562_Hela1.26974679
63P300_19829295_ChIP-Seq_ESCs_Human1.26224024
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23873969
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.23192963
66CTCF_20526341_ChIP-Seq_ESCs_Human1.20172749
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19899747
68* OCT4_19829295_ChIP-Seq_ESCs_Human1.19003758
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.17663879
70* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17655386
71SMC4_20622854_ChIP-Seq_HELA_Human1.17384519
72ERA_21632823_ChIP-Seq_H3396_Human1.16753898
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16592953
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.16536811
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15756660
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14410669
77KDM2B_26808549_Chip-Seq_K562_Human1.13164978
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12651318
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12454013
80AR_25329375_ChIP-Seq_VCAP_Human1.11423374
81NANOG_20526341_ChIP-Seq_ESCs_Human1.10387890
82* STAT3_23295773_ChIP-Seq_U87_Human1.08737626
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08156737
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08156737
85AR_19668381_ChIP-Seq_PC3_Human1.07773127
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07685592
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07552361
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07132847
89TAF2_19829295_ChIP-Seq_ESCs_Human1.06751919
90RNF2_27304074_Chip-Seq_NSC_Mouse1.06744598
91SA1_27219007_Chip-Seq_Bcells_Human1.06571303
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06086086
93* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05891528
94P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05411358
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05128411
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04834765
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04479068
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03755295
99VDR_22108803_ChIP-Seq_LS180_Human1.02116720
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.01055417
101MYC_19829295_ChIP-Seq_ESCs_Human1.00822894
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00740387
103* OCT4_20526341_ChIP-Seq_ESCs_Human1.00448239
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00418018
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98852757
106TP63_22573176_ChIP-Seq_HFKS_Human0.98800545
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98564895
108AHR_22903824_ChIP-Seq_MCF-7_Human0.98355529
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98348426
110ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98300910
111* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96593054
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.96412005
113CREB1_26743006_Chip-Seq_LNCaP_Human0.96190306
114TP53_18474530_ChIP-ChIP_U2OS_Human0.96078387
115RUNX2_22187159_ChIP-Seq_PCA_Human0.95350966
116P300_27268052_Chip-Seq_Bcells_Human0.95314348
117IGF1R_20145208_ChIP-Seq_DFB_Human0.94917406
118TCF4_23295773_ChIP-Seq_U87_Human0.94648895
119BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94408001
120WDR5_24793694_ChIP-Seq_LNCAP_Human0.93909248
121PRDM14_20953172_ChIP-Seq_ESCs_Human0.93840837
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.93417403
123NCOR_22424771_ChIP-Seq_293T_Human0.92500652
124VDR_21846776_ChIP-Seq_THP-1_Human0.92449268
125OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92381791
126TET1_21451524_ChIP-Seq_MESCs_Mouse0.91470912
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90890065
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90754977
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89815210
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89046076
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.88588761
132* YY1_22570637_ChIP-Seq_MALME-3M_Human0.88430094
133EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88243061
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88049648
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87796305
136SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87662136
137RXR_22108803_ChIP-Seq_LS180_Human0.87066367
138CTCF_27219007_Chip-Seq_Bcells_Human0.86743338
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86508522
140* KLF4_19829295_ChIP-Seq_ESCs_Human0.86337325
141* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86235338
142TP53_20018659_ChIP-ChIP_R1E_Mouse0.86020988
143ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85336018
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85216981
145* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85043199
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84572710
147TP53_16413492_ChIP-PET_HCT116_Human0.83837852
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82393791
149RAC3_21632823_ChIP-Seq_H3396_Human0.82346302
150BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.82238804
151BCAT_22108803_ChIP-Seq_LS180_Human0.81788763
152SOX2_21211035_ChIP-Seq_LN229_Human0.79349227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.80267300
2MP0002822_catalepsy4.08066991
3MP0003880_abnormal_central_pattern3.93475636
4MP0003635_abnormal_synaptic_transmissio3.73105593
5MP0005360_urolithiasis3.61412137
6MP0004270_analgesia3.56572709
7MP0009780_abnormal_chondrocyte_physiolo3.38903761
8MP0002063_abnormal_learning/memory/cond3.20759583
9MP0009745_abnormal_behavioral_response3.03521682
10MP0003183_abnormal_peptide_metabolism2.74055817
11MP0009379_abnormal_foot_pigmentation2.68134881
12MP0005423_abnormal_somatic_nervous2.67567248
13MP0003283_abnormal_digestive_organ2.56429186
14MP0002064_seizures2.53041764
15MP0002572_abnormal_emotion/affect_behav2.52555105
16MP0002734_abnormal_mechanical_nocicepti2.46744818
17MP0001986_abnormal_taste_sensitivity2.39838014
18MP0001968_abnormal_touch/_nociception2.38418465
19MP0004043_abnormal_pH_regulation2.28402003
20MP0004019_abnormal_vitamin_homeostasis2.25398721
21MP0001486_abnormal_startle_reflex2.23509766
22MP0002735_abnormal_chemical_nociception2.20006710
23MP0005085_abnormal_gallbladder_physiolo2.19436043
24MP0009046_muscle_twitch2.15238182
25MP0001666_abnormal_nutrient_absorption2.14768809
26MP0000778_abnormal_nervous_system2.06539849
27MP0002733_abnormal_thermal_nociception1.96242387
28MP0002272_abnormal_nervous_system1.89470435
29MP0002184_abnormal_innervation1.87919902
30MP0004134_abnormal_chest_morphology1.86803301
31MP0005174_abnormal_tail_pigmentation1.86240362
32MP0001440_abnormal_grooming_behavior1.83265145
33MP0001970_abnormal_pain_threshold1.80782982
34MP0003646_muscle_fatigue1.78605857
35* MP0002909_abnormal_adrenal_gland1.77400189
36MP0003787_abnormal_imprinting1.75947407
37MP0005365_abnormal_bile_salt1.72802755
38MP0005386_behavior/neurological_phenoty1.72515086
39MP0004924_abnormal_behavior1.72515086
40MP0006276_abnormal_autonomic_nervous1.71754631
41MP0002736_abnormal_nociception_after1.71658785
42MP0001501_abnormal_sleep_pattern1.71064405
43MP0002557_abnormal_social/conspecific_i1.70346358
44MP0001765_abnormal_ion_homeostasis1.69006139
45MP0004147_increased_porphyrin_level1.65541705
46MP0001188_hyperpigmentation1.65355564
47MP0008875_abnormal_xenobiotic_pharmacok1.60411488
48MP0003866_abnormal_defecation1.57575780
49MP0001529_abnormal_vocalization1.56156303
50MP0004811_abnormal_neuron_physiology1.55503990
51MP0005646_abnormal_pituitary_gland1.51276019
52MP0003329_amyloid_beta_deposits1.48158002
53MP0000751_myopathy1.48050600
54MP0002067_abnormal_sensory_capabilities1.47630761
55MP0000955_abnormal_spinal_cord1.46870299
56MP0005645_abnormal_hypothalamus_physiol1.46497471
57MP0000569_abnormal_digit_pigmentation1.46119492
58MP0004858_abnormal_nervous_system1.46043327
59MP0010155_abnormal_intestine_physiology1.41212293
60MP0008569_lethality_at_weaning1.38510040
61MP0003879_abnormal_hair_cell1.36941396
62MP0002653_abnormal_ependyma_morphology1.33061112
63MP0002139_abnormal_hepatobiliary_system1.30997508
64MP0002882_abnormal_neuron_morphology1.21976009
65MP0000015_abnormal_ear_pigmentation1.21378876
66MP0002066_abnormal_motor_capabilities/c1.21181990
67MP0002234_abnormal_pharynx_morphology1.18926237
68MP0001299_abnormal_eye_distance/1.17965594
69MP0009250_abnormal_appendicular_skeleto1.17462282
70MP0001984_abnormal_olfaction1.17401923
71MP0004264_abnormal_extraembryonic_tissu1.16986656
72MP0000538_abnormal_urinary_bladder1.14081270
73MP0005503_abnormal_tendon_morphology1.14070726
74MP0004885_abnormal_endolymph1.13408327
75MP0005551_abnormal_eye_electrophysiolog1.11273423
76MP0001485_abnormal_pinna_reflex1.10939686
77MP0002089_abnormal_postnatal_growth/wei1.10546914
78MP0001756_abnormal_urination1.09698115
79MP0010386_abnormal_urinary_bladder1.07629233
80MP0003122_maternal_imprinting1.07270820
81MP0001664_abnormal_digestion1.06537500
82MP0008789_abnormal_olfactory_epithelium1.05844204
83MP0002277_abnormal_respiratory_mucosa1.05350581
84MP0000462_abnormal_digestive_system1.05095752
85MP0001905_abnormal_dopamine_level1.04119715
86MP0002796_impaired_skin_barrier1.03295779
87MP0010329_abnormal_lipoprotein_level1.00624750
88MP0005448_abnormal_energy_balance1.00290112
89MP0001502_abnormal_circadian_rhythm0.99274539
90MP0002282_abnormal_trachea_morphology0.98635330
91* MP0000163_abnormal_cartilage_morphology0.98456330
92MP0005409_darkened_coat_color0.97944371
93MP0001177_atelectasis0.97927409
94* MP0002152_abnormal_brain_morphology0.97759614
95MP0002069_abnormal_eating/drinking_beha0.96126294
96* MP0002896_abnormal_bone_mineralization0.95937187
97MP0001963_abnormal_hearing_physiology0.94988394
98MP0005377_hearing/vestibular/ear_phenot0.93324296
99MP0003878_abnormal_ear_physiology0.93324296
100* MP0000631_abnormal_neuroendocrine_gland0.92153033
101MP0002933_joint_inflammation0.88901219
102MP0009643_abnormal_urine_homeostasis0.87625226
103MP0003633_abnormal_nervous_system0.87107585
104MP0009840_abnormal_foam_cell0.85747998
105MP0004742_abnormal_vestibular_system0.85226475
106MP0005332_abnormal_amino_acid0.83980862
107MP0001663_abnormal_digestive_system0.82757939
108MP0004381_abnormal_hair_follicle0.80996610
109MP0008961_abnormal_basal_metabolism0.80550670
110MP0005636_abnormal_mineral_homeostasis0.80463644
111MP0010234_abnormal_vibrissa_follicle0.78004886
112MP0005187_abnormal_penis_morphology0.77311918
113MP0003011_delayed_dark_adaptation0.77069570
114* MP0002115_abnormal_skeleton_extremities0.76404835
115MP0000013_abnormal_adipose_tissue0.76137066
116MP0004085_abnormal_heartbeat0.73056265
117MP0002136_abnormal_kidney_physiology0.71436620
118MP0000230_abnormal_systemic_arterial0.71382401
119MP0005394_taste/olfaction_phenotype0.70431804
120MP0005499_abnormal_olfactory_system0.70431804
121MP0003631_nervous_system_phenotype0.69796930
122MP0000566_synostosis0.69057008
123MP0001943_abnormal_respiration0.69015557
124MP0002229_neurodegeneration0.67864599
125MP0008872_abnormal_physiological_respon0.67784027
126MP0003075_altered_response_to0.66993779
127MP0004133_heterotaxia0.66631889
128MP0000678_abnormal_parathyroid_gland0.66453213
129MP0002116_abnormal_craniofacial_bone0.65148738
130MP0000026_abnormal_inner_ear0.65117795
131MP0002752_abnormal_somatic_nervous0.64909737
132MP0003724_increased_susceptibility_to0.64496852
133MP0003119_abnormal_digestive_system0.64459720
134MP0005083_abnormal_biliary_tract0.63812036
135MP0002876_abnormal_thyroid_physiology0.62677230
136MP0005535_abnormal_body_temperature0.62036517
137MP0001270_distended_abdomen0.60682251
138MP0002751_abnormal_autonomic_nervous0.59135667
139MP0002090_abnormal_vision0.59072233
140MP0002638_abnormal_pupillary_reflex0.59002294
141MP0004142_abnormal_muscle_tone0.58128784
142MP0003861_abnormal_nervous_system0.57960193
143MP0002233_abnormal_nose_morphology0.57867033
144MP0005381_digestive/alimentary_phenotyp0.56158355
145MP0005248_abnormal_Harderian_gland0.55415537

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)7.01742430
2Irregular epiphyses (HP:0010582)6.23010255
3Small epiphyses (HP:0010585)5.03233776
4Myokymia (HP:0002411)4.89649380
5Vitreoretinal degeneration (HP:0000655)4.86989610
6Abnormal respiratory motile cilium morphology (HP:0005938)4.86435306
7Abnormal respiratory epithelium morphology (HP:0012253)4.86435306
8Decreased circulating renin level (HP:0003351)4.79145467
9Abnormal tarsal ossification (HP:0008369)4.59473461
10Focal motor seizures (HP:0011153)4.53329268
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.47640668
12Absent/shortened dynein arms (HP:0200106)4.39026555
13Dynein arm defect of respiratory motile cilia (HP:0012255)4.39026555
14Abnormal ciliary motility (HP:0012262)4.36581586
15Cupped ribs (HP:0000887)4.36257884
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.33345532
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.31506725
18Delayed epiphyseal ossification (HP:0002663)4.23923176
19Abnormal respiratory motile cilium physiology (HP:0012261)4.20041762
20Genu varum (HP:0002970)4.05506682
21Hypoplastic ischia (HP:0003175)4.04033258
22Malnutrition (HP:0004395)3.76804443
23Flat capital femoral epiphysis (HP:0003370)3.70330780
24Rhinitis (HP:0012384)3.69000658
25Abnormality of the ischium (HP:0003174)3.56812430
26Mild short stature (HP:0003502)3.55461600
27Hyperactive renin-angiotensin system (HP:0000841)3.54435902
28Flat acetabular roof (HP:0003180)3.52991391
29Focal seizures (HP:0007359)3.50917588
30Abnormality of renin-angiotensin system (HP:0000847)3.45193119
31Short femoral neck (HP:0100864)3.33299711
32Widely patent fontanelles and sutures (HP:0004492)3.21867152
33Neonatal short-limb short stature (HP:0008921)3.20921388
34Abnormality of the vertebral endplates (HP:0005106)3.19632247
35Metaphyseal cupping (HP:0003021)3.15799630
36Abnormality of femoral epiphyses (HP:0006499)3.12061907
37Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.12061907
38Epileptic encephalopathy (HP:0200134)3.11499872
39Abnormality of the vitamin B12 metabolism (HP:0004341)3.11301614
40Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.03886364
41Chronic bronchitis (HP:0004469)3.01662066
42Congenital stationary night blindness (HP:0007642)3.00638780
43Flattened epiphyses (HP:0003071)2.97460447
44Bronchiectasis (HP:0002110)2.96993511
45Akinesia (HP:0002304)2.95188337
46Visual hallucinations (HP:0002367)2.93733489
47Abnormality of the epiphysis of the femoral head (HP:0010574)2.93522208
48Spinal cord compression (HP:0002176)2.93343613
49Abnormality of vitamin B metabolism (HP:0004340)2.90925404
50Nasal polyposis (HP:0100582)2.90506956
51Abnormal foot bone ossification (HP:0010675)2.88765060
52Osteoarthritis (HP:0002758)2.87473779
53Polyphagia (HP:0002591)2.87439911
54Hydroxyprolinuria (HP:0003080)2.87350765
55Abnormality of proline metabolism (HP:0010907)2.87350765
56Torticollis (HP:0000473)2.82180516
57Irregular vertebral endplates (HP:0003301)2.79108796
58Thin bony cortex (HP:0002753)2.78767193
59Confusion (HP:0001289)2.78166485
60Broad-based gait (HP:0002136)2.77459899
61Congenital sensorineural hearing impairment (HP:0008527)2.71506260
62Metaphyseal irregularity (HP:0003025)2.69854218
63Abnormality of the femoral head (HP:0003368)2.67518641
64Absent epiphyses (HP:0010577)2.64456180
65Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.64456180
66Arthropathy (HP:0003040)2.61222456
67Abnormality of the pubic bones (HP:0003172)2.57908164
68Waddling gait (HP:0002515)2.57221511
69Metaphyseal dysplasia (HP:0100255)2.56803336
70Hemorrhage of the eye (HP:0011885)2.48506301
71Genetic anticipation (HP:0003743)2.48183148
72Supranuclear gaze palsy (HP:0000605)2.48101292
73Ankle clonus (HP:0011448)2.46669852
74Relative macrocephaly (HP:0004482)2.43077223
75Focal dystonia (HP:0004373)2.41952610
76Rib fusion (HP:0000902)2.39504987
77Abnormal albumin level (HP:0012116)2.38850840
78Hypoalbuminemia (HP:0003073)2.38850840
79Limited hip movement (HP:0008800)2.38509071
80Aplasia/hypoplasia of the femur (HP:0005613)2.36346851
81Abnormality of carpal bone ossification (HP:0006257)2.36212276
82Abnormality of the nasal mucosa (HP:0000433)2.35906782
83Metabolic alkalosis (HP:0200114)2.35602449
84Mutism (HP:0002300)2.32642480
85Craniofacial dystonia (HP:0012179)2.29839350
86Progressive cerebellar ataxia (HP:0002073)2.28286843
87Poor eye contact (HP:0000817)2.26023544
88Chronic diarrhea (HP:0002028)2.25261395
89Papilledema (HP:0001085)2.24094748
90Decreased central vision (HP:0007663)2.23936001
91Lower limb asymmetry (HP:0100559)2.22802726
92Obstructive sleep apnea (HP:0002870)2.21221891
93Attenuation of retinal blood vessels (HP:0007843)2.18650429
94Abnormality of midbrain morphology (HP:0002418)2.18468479
95Molar tooth sign on MRI (HP:0002419)2.18468479
96Glycosuria (HP:0003076)2.18204596
97Abnormality of urine glucose concentration (HP:0011016)2.18204596
98Bony spicule pigmentary retinopathy (HP:0007737)2.18163531
99Febrile seizures (HP:0002373)2.17642408
100Alkalosis (HP:0001948)2.17071435
101Action tremor (HP:0002345)2.16927607
102Enlarged epiphyses (HP:0010580)2.16763357
103Abnormality of vitamin metabolism (HP:0100508)2.15615430
104Coxa vara (HP:0002812)2.15593888
105Chronic sinusitis (HP:0011109)2.13127421
106Fetal akinesia sequence (HP:0001989)2.11204173
107Hyperaldosteronism (HP:0000859)2.11196773
108Abnormality of the proximal phalanges of the hand (HP:0009834)2.10102852
109Chronic hepatic failure (HP:0100626)2.09637896
110Limb dystonia (HP:0002451)2.09564536
111Protuberant abdomen (HP:0001538)2.08880735
112Generalized tonic-clonic seizures (HP:0002069)2.08029341
113Ovoid vertebral bodies (HP:0003300)2.07713705
114Excessive salivation (HP:0003781)2.06687058
115Drooling (HP:0002307)2.06687058
116Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.06506946
117Absent speech (HP:0001344)2.05556975
118Infertility (HP:0000789)2.04522667
119Absence seizures (HP:0002121)2.03571518
120Exostoses (HP:0100777)2.02107706
121Amblyopia (HP:0000646)2.01959477
122Abnormality of chloride homeostasis (HP:0011422)2.01826389
123Nephronophthisis (HP:0000090)2.01734984
124Limited elbow extension (HP:0001377)2.00389122
125Increased IgE level (HP:0003212)1.99901116
126Megalencephaly (HP:0001355)1.99786737
127Neurofibrillary tangles (HP:0002185)1.99528532
128Impaired social interactions (HP:0000735)1.99059975
129Abnormal social behavior (HP:0012433)1.99059975
130Barrel-shaped chest (HP:0001552)1.98860102
131Cerebral inclusion bodies (HP:0100314)1.98849274
132Hepatoblastoma (HP:0002884)1.98624657
133Abnormal urine phosphate concentration (HP:0012599)1.98450255
134Absent frontal sinuses (HP:0002688)1.97162739
135Hip contracture (HP:0003273)1.96755926
136Anxiety (HP:0000739)1.96642169
137Urinary urgency (HP:0000012)1.96427601
138Hypoplasia of the odontoid process (HP:0003311)1.95045760
139Agitation (HP:0000713)1.94438569
140Abnormality of the phalanges of the 2nd finger (HP:0009541)1.92175585
141Platyspondyly (HP:0000926)1.92111414
142Hyperventilation (HP:0002883)1.89273412
143Beaking of vertebral bodies (HP:0004568)1.88421699
144Impaired vibration sensation in the lower limbs (HP:0002166)1.88137823
145Mixed hearing impairment (HP:0000410)1.87922304
146Abnormal vertebral ossification (HP:0100569)1.87777957
147Lumbar hyperlordosis (HP:0002938)1.87052825
148Depression (HP:0000716)1.87047265
149Chorioretinal atrophy (HP:0000533)1.86588820
150Thoracolumbar scoliosis (HP:0002944)1.84810842
151Eczematoid dermatitis (HP:0000976)1.83863702
152Recurrent sinusitis (HP:0011108)1.82578070
153Bronchitis (HP:0012387)1.81117300
154Atonic seizures (HP:0010819)1.80466920
155Abnormal eating behavior (HP:0100738)1.79012539
156Dialeptic seizures (HP:0011146)1.78209109
157Epileptiform EEG discharges (HP:0011182)1.77980968
158Abnormal hand bone ossification (HP:0010660)1.77851797
159Potter facies (HP:0002009)1.77387614
160Facial shape deformation (HP:0011334)1.77387614
161Acanthocytosis (HP:0001927)1.77145197
162Neonatal onset (HP:0003623)1.75560437
163Polydipsia (HP:0001959)1.72807534
164Abnormal drinking behavior (HP:0030082)1.72807534
165Ileus (HP:0002595)1.72597001
166Prolonged QT interval (HP:0001657)1.71907646
167Intellectual disability, severe (HP:0010864)1.71487962
168Annular pancreas (HP:0001734)1.71484778
169Pancreatic cysts (HP:0001737)1.70691401
170Hyperglycinuria (HP:0003108)1.69155368
171Hyperkalemia (HP:0002153)1.66077254
172Hypokalemia (HP:0002900)1.65558801
173Pigmentary retinal degeneration (HP:0001146)1.64243819
174Gait imbalance (HP:0002141)1.63007159
175Chronic otitis media (HP:0000389)1.62424797
176Cystic liver disease (HP:0006706)1.62138091
177Abnormality of the costochondral junction (HP:0000919)1.61219939
178Abnormality of potassium homeostasis (HP:0011042)1.58899906
179Abnormality of renal excretion (HP:0011036)1.58085954
180Ventricular fibrillation (HP:0001663)1.57991399
181Wide cranial sutures (HP:0010537)1.57856413
182Abnormality of the renal medulla (HP:0100957)1.57665442
183Syncope (HP:0001279)1.57618721
184True hermaphroditism (HP:0010459)1.56790304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.08309816
2EPHA45.05320024
3MAPK154.07200441
4NTRK33.87590070
5MAP3K93.46021048
6ACVR1B3.38292289
7MINK12.47847841
8DAPK22.44267978
9MAP3K42.38983840
10DDR22.29272928
11NTRK22.12789526
12ERN12.03931637
13KSR12.01036759
14PRKD31.91193248
15MAP2K71.86079126
16CAMKK11.85519701
17WNK41.80542145
18PAK61.79772300
19NTRK11.78294632
20KSR21.77106966
21CASK1.74990701
22SIK21.64923138
23MAPK131.61417311
24CDK51.58442734
25RIPK41.57948812
26GRK61.57068296
27TAOK11.49874671
28INSRR1.44731252
29ADRBK21.41627645
30EPHA31.39524245
31NME11.39283668
32PLK21.38662246
33MAP2K21.37282669
34ERBB31.32688638
35PHKG11.32229198
36PHKG21.32229198
37OXSR11.30245104
38MAP3K21.29028635
39PINK11.21936978
40DYRK1B1.21083284
41CAMKK21.19371010
42MAP2K41.19104308
43LATS21.18755304
44DYRK21.17960244
45TNIK1.15854206
46DAPK11.14833381
47MAP4K11.12266792
48STK391.05218873
49PRKCG1.03609116
50DYRK1A1.02658188
51GRK51.02120755
52MAP3K120.99544047
53UHMK10.98635178
54EPHA20.95446816
55CSNK1G20.93210035
56PRPF4B0.92351762
57TLK10.91473658
58CAMK2A0.90007499
59FES0.89004893
60TYRO30.88941433
61GRK10.88563511
62MARK20.88350304
63MAP3K110.86993609
64TAOK30.85552572
65PNCK0.84199016
66PRKG20.84001296
67ERBB20.83779595
68STK110.83393598
69TNK20.83161926
70MST1R0.82784282
71NLK0.79302928
72CAMK2B0.79254528
73CDK180.78239554
74CDK140.78018260
75RET0.76670755
76BMPR20.74948191
77CDK150.74707999
78PAK30.74300898
79LMTK20.72537120
80ADRBK10.72459478
81PRKCZ0.71132697
82SGK10.70135239
83EPHB20.68016505
84EPHB10.67095575
85BCR0.66669649
86STK380.65500467
87CDK11A0.64666480
88SGK2230.63551255
89SGK4940.63551255
90ARAF0.62779600
91PTK2B0.61688772
92CAMK40.61276854
93FER0.59316492
94RAF10.59111785
95WNK30.58818996
96MAP2K10.58540065
97PRKCE0.57913875
98CAMK10.57813451
99TESK20.57554994
100PTK60.56966162
101PRKCQ0.56302074
102BLK0.55719128
103SYK0.55017560
104WNK10.54022159
105MAP3K100.53865177
106FYN0.52548508
107RPS6KA20.51512791
108MAP3K70.50690908
109MUSK0.50289475
110MAPK120.49848947
111IRAK20.48863873
112STK240.47934241
113PRKACA0.47490536
114CSK0.46687489
115SGK20.45872247
116ROCK10.45817253
117PRKCA0.45790596
118PRKAA10.45537189
119CSNK1A1L0.45494039
120CSNK1G30.44900304
121CDC42BPA0.43502769
122PRKCH0.43415510
123PIK3CA0.42084450
124CAMK1G0.41728652
125SIK30.41536806
126TXK0.41082131
127FRK0.40802449
128PRKCI0.39186226
129MAP3K10.38976341
130PDPK10.37831518
131RPS6KA30.37616959
132MAPK100.37592769
133PRKACG0.37508438
134RPS6KA60.37420870
135SGK30.36721104
136CAMK2D0.35733996
137CDK190.35244825
138PKN10.35155060
139ICK0.35084583
140PDK10.34657872
141MAP3K130.34011358
142PRKG10.33803853
143MAP2K60.32750640
144FGFR20.32372413
145MAP3K60.32248601
146RIPK10.31067894

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.10940275
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.07724276
3Olfactory transduction_Homo sapiens_hsa047403.07157137
4Circadian entrainment_Homo sapiens_hsa047132.67631140
5Fat digestion and absorption_Homo sapiens_hsa049752.60468679
6Vitamin digestion and absorption_Homo sapiens_hsa049772.54518600
7Synaptic vesicle cycle_Homo sapiens_hsa047212.49016134
8Amphetamine addiction_Homo sapiens_hsa050312.47757785
9GABAergic synapse_Homo sapiens_hsa047272.40166132
10Morphine addiction_Homo sapiens_hsa050322.40055692
11Long-term potentiation_Homo sapiens_hsa047202.38305608
12Glutamatergic synapse_Homo sapiens_hsa047242.35894795
13Linoleic acid metabolism_Homo sapiens_hsa005912.35789957
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34054022
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26505326
16Dopaminergic synapse_Homo sapiens_hsa047282.24731451
17Cocaine addiction_Homo sapiens_hsa050302.17356440
18Salivary secretion_Homo sapiens_hsa049702.11585464
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10503378
20Cholinergic synapse_Homo sapiens_hsa047252.09316326
21Histidine metabolism_Homo sapiens_hsa003401.91435391
22Insulin secretion_Homo sapiens_hsa049111.91117785
23Renin-angiotensin system_Homo sapiens_hsa046141.88535068
24Renin secretion_Homo sapiens_hsa049241.83362776
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78667380
26Long-term depression_Homo sapiens_hsa047301.74388401
27Gastric acid secretion_Homo sapiens_hsa049711.72768683
28Serotonergic synapse_Homo sapiens_hsa047261.67686811
29Oxytocin signaling pathway_Homo sapiens_hsa049211.60727079
30Mineral absorption_Homo sapiens_hsa049781.59585628
31Gap junction_Homo sapiens_hsa045401.57788714
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54213624
33Taste transduction_Homo sapiens_hsa047421.52345531
34Axon guidance_Homo sapiens_hsa043601.52175797
35Chemical carcinogenesis_Homo sapiens_hsa052041.46354133
36Caffeine metabolism_Homo sapiens_hsa002321.46128728
37Calcium signaling pathway_Homo sapiens_hsa040201.41819529
38Ether lipid metabolism_Homo sapiens_hsa005651.41165058
39GnRH signaling pathway_Homo sapiens_hsa049121.37717409
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36057419
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34461411
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.30902295
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30662901
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28442636
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26868421
46cAMP signaling pathway_Homo sapiens_hsa040241.21038597
47Retinol metabolism_Homo sapiens_hsa008301.20556716
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18670083
49Estrogen signaling pathway_Homo sapiens_hsa049151.17613340
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15193165
51Melanogenesis_Homo sapiens_hsa049161.14771210
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14482459
53Arachidonic acid metabolism_Homo sapiens_hsa005901.14021399
54Glioma_Homo sapiens_hsa052141.13381501
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.13123043
56Type II diabetes mellitus_Homo sapiens_hsa049301.08341982
57ErbB signaling pathway_Homo sapiens_hsa040121.04356385
58Arginine biosynthesis_Homo sapiens_hsa002201.01629926
59Protein digestion and absorption_Homo sapiens_hsa049741.00073503
60Glycerolipid metabolism_Homo sapiens_hsa005610.98218878
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97801317
62Asthma_Homo sapiens_hsa053100.94389631
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93906057
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93795907
65Starch and sucrose metabolism_Homo sapiens_hsa005000.93386903
66Vibrio cholerae infection_Homo sapiens_hsa051100.93308667
67Fructose and mannose metabolism_Homo sapiens_hsa000510.92969273
68Thyroid hormone synthesis_Homo sapiens_hsa049180.91242361
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.89952634
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.89419592
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.87359028
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86225301
73Graft-versus-host disease_Homo sapiens_hsa053320.86107278
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85778517
75Autoimmune thyroid disease_Homo sapiens_hsa053200.85637878
76ECM-receptor interaction_Homo sapiens_hsa045120.85125332
77PPAR signaling pathway_Homo sapiens_hsa033200.85009921
78Collecting duct acid secretion_Homo sapiens_hsa049660.83981048
79Phototransduction_Homo sapiens_hsa047440.83469946
80Allograft rejection_Homo sapiens_hsa053300.82570264
81Pancreatic secretion_Homo sapiens_hsa049720.80771547
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78929133
83Phenylalanine metabolism_Homo sapiens_hsa003600.76825254
84Dorso-ventral axis formation_Homo sapiens_hsa043200.74870580
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74692772
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.74573277
87Choline metabolism in cancer_Homo sapiens_hsa052310.71919237
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71879582
89Cardiac muscle contraction_Homo sapiens_hsa042600.71216526
90Alcoholism_Homo sapiens_hsa050340.69250798
91Endometrial cancer_Homo sapiens_hsa052130.68258298
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67991056
93Dilated cardiomyopathy_Homo sapiens_hsa054140.65780841
94ABC transporters_Homo sapiens_hsa020100.64548397
95MAPK signaling pathway_Homo sapiens_hsa040100.63772364
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.63094788
97VEGF signaling pathway_Homo sapiens_hsa043700.61995479
98Ras signaling pathway_Homo sapiens_hsa040140.61162924
99Rap1 signaling pathway_Homo sapiens_hsa040150.60378097
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.60310612
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60232563
102Wnt signaling pathway_Homo sapiens_hsa043100.59009511
103Tryptophan metabolism_Homo sapiens_hsa003800.58497950
104Glucagon signaling pathway_Homo sapiens_hsa049220.57063519
105Oocyte meiosis_Homo sapiens_hsa041140.56944768
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56418998
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55788389
108Sulfur relay system_Homo sapiens_hsa041220.55037408
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53951156
110Bile secretion_Homo sapiens_hsa049760.53171500
111Renal cell carcinoma_Homo sapiens_hsa052110.52226900
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51781248
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51214642
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50990025
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50338385
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.48594528
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48461429
118Focal adhesion_Homo sapiens_hsa045100.48159458
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46930634
120Ovarian steroidogenesis_Homo sapiens_hsa049130.46891581
121mTOR signaling pathway_Homo sapiens_hsa041500.45482959
122Staphylococcus aureus infection_Homo sapiens_hsa051500.45324420
123Hedgehog signaling pathway_Homo sapiens_hsa043400.44828955
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42895834
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42315981
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42210695
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41611008
128Non-small cell lung cancer_Homo sapiens_hsa052230.41492196
129Colorectal cancer_Homo sapiens_hsa052100.40956068
130Type I diabetes mellitus_Homo sapiens_hsa049400.40631358
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39952656
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38808335
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37273676
134Sulfur metabolism_Homo sapiens_hsa009200.37225044
135Hippo signaling pathway_Homo sapiens_hsa043900.37101635
136Insulin signaling pathway_Homo sapiens_hsa049100.36919293
137Circadian rhythm_Homo sapiens_hsa047100.36783643
138Nitrogen metabolism_Homo sapiens_hsa009100.35888352
139Endocytosis_Homo sapiens_hsa041440.33863346
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33770577
141Chemokine signaling pathway_Homo sapiens_hsa040620.32670768
142Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32599183

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