SMPD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.33250219
2tricarboxylic acid cycle (GO:0006099)4.26617375
3regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.23874340
4NADH metabolic process (GO:0006734)4.19349833
5cell communication by electrical coupling (GO:0010644)4.15817936
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.08836466
7virion attachment to host cell (GO:0019062)3.95549061
8adhesion of symbiont to host cell (GO:0044650)3.95549061
9regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.83978377
10regulation of extracellular matrix disassembly (GO:0010715)3.65160165
11skin morphogenesis (GO:0043589)3.58215548
12regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.57269030
13sodium ion export (GO:0071436)3.55863712
14cellular potassium ion homeostasis (GO:0030007)3.55053191
15CDP-diacylglycerol metabolic process (GO:0046341)3.54131803
16adhesion of symbiont to host (GO:0044406)3.50214167
17regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.34060463
18aspartate family amino acid catabolic process (GO:0009068)3.33056431
192-oxoglutarate metabolic process (GO:0006103)3.30447783
20barbed-end actin filament capping (GO:0051016)3.30055439
21type B pancreatic cell proliferation (GO:0044342)3.28100711
22protein heterotrimerization (GO:0070208)3.26939948
23regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.26604148
24endodermal cell differentiation (GO:0035987)3.23017302
25potassium ion import (GO:0010107)3.19249453
26lysine catabolic process (GO:0006554)3.19067549
27lysine metabolic process (GO:0006553)3.19067549
28cell communication involved in cardiac conduction (GO:0086065)3.18614898
29cell adhesion mediated by integrin (GO:0033627)3.17494402
30succinate metabolic process (GO:0006105)3.15923752
31positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.15383712
32regulation of acyl-CoA biosynthetic process (GO:0050812)3.13974935
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.11406580
34biotin metabolic process (GO:0006768)3.10993718
35negative regulation of potassium ion transmembrane transport (GO:1901380)3.10697847
36ventricular cardiac muscle cell action potential (GO:0086005)3.10374202
37creatine metabolic process (GO:0006600)3.07799041
38short-chain fatty acid metabolic process (GO:0046459)3.06187747
39sarcomere organization (GO:0045214)3.02596453
40regulation of membrane repolarization (GO:0060306)3.02595582
41CDP-diacylglycerol biosynthetic process (GO:0016024)3.00444089
42regulation of short-term neuronal synaptic plasticity (GO:0048172)2.98090166
43cellular ketone body metabolic process (GO:0046950)2.97916602
44regulation of integrin-mediated signaling pathway (GO:2001044)2.97706772
45negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.94616494
46mannose metabolic process (GO:0006013)2.94358349
47mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94233641
48protein carboxylation (GO:0018214)2.93596453
49peptidyl-glutamic acid carboxylation (GO:0017187)2.93596453
50regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91863060
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90435943
52carnitine shuttle (GO:0006853)2.89248825
53ketone body metabolic process (GO:1902224)2.88570967
54fatty acid beta-oxidation (GO:0006635)2.88019912
55regulation of coenzyme metabolic process (GO:0051196)2.87983601
56regulation of cofactor metabolic process (GO:0051193)2.87983601
57positive regulation of extracellular matrix organization (GO:1903055)2.84418501
58cardiac muscle contraction (GO:0060048)2.83410288
59stress fiber assembly (GO:0043149)2.83348053
60cellular sodium ion homeostasis (GO:0006883)2.83255126
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83031872
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.82586395
63tricarboxylic acid metabolic process (GO:0072350)2.82190065
64protein localization to endosome (GO:0036010)2.81704264
65collagen fibril organization (GO:0030199)2.79911815
66sequestering of extracellular ligand from receptor (GO:0035581)2.78621757
67basement membrane organization (GO:0071711)2.78330618
68fatty acid catabolic process (GO:0009062)2.75938842
69branched-chain amino acid catabolic process (GO:0009083)2.74833831
70cardiac myofibril assembly (GO:0055003)2.74649022
71carnitine metabolic process (GO:0009437)2.73871986
72regulation of fatty acid oxidation (GO:0046320)2.73599184
73respiratory electron transport chain (GO:0022904)2.73103400
74macroautophagy (GO:0016236)2.71014209
75keratan sulfate catabolic process (GO:0042340)2.70532152
76regulation of plasminogen activation (GO:0010755)2.69896564
77cell migration involved in heart development (GO:0060973)2.69666003
78amino-acid betaine metabolic process (GO:0006577)2.68948799
79regulation of actin filament-based movement (GO:1903115)2.68795002
80dicarboxylic acid catabolic process (GO:0043649)2.68444801
81hyaluronan catabolic process (GO:0030214)2.67458318
82electron transport chain (GO:0022900)2.66134346
83positive regulation of sodium ion transport (GO:0010765)2.65492454
84potassium ion homeostasis (GO:0055075)2.65022010
85fatty acid transmembrane transport (GO:1902001)2.64459468
86venous blood vessel morphogenesis (GO:0048845)2.63743263
87protein retention in ER lumen (GO:0006621)2.63384645
88extracellular fibril organization (GO:0043206)2.62515955
89extracellular matrix assembly (GO:0085029)2.62096573
90apoptotic cell clearance (GO:0043277)2.59924990
91blood vessel maturation (GO:0001955)2.58149098
92ATP synthesis coupled proton transport (GO:0015986)2.57445532
93energy coupled proton transport, down electrochemical gradient (GO:0015985)2.57445532
94regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.55494563
95lipid oxidation (GO:0034440)2.55333504
96regulation of fibrinolysis (GO:0051917)2.55208986
97acetyl-CoA metabolic process (GO:0006084)2.55191005
98fibril organization (GO:0097435)2.55029197
99COPI coating of Golgi vesicle (GO:0048205)2.54634030
100Golgi transport vesicle coating (GO:0048200)2.54634030
101fatty acid oxidation (GO:0019395)2.53706858
102negative regulation of fibrinolysis (GO:0051918)2.53297309
103neuromuscular process controlling posture (GO:0050884)2.52545896
104plasma membrane repair (GO:0001778)2.52406458
105maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52402616
106carnitine transport (GO:0015879)2.50905749
107amino-acid betaine transport (GO:0015838)2.50905749
108collagen metabolic process (GO:0032963)2.50391966
109regulation of sulfur metabolic process (GO:0042762)2.50356327
110carnitine transmembrane transport (GO:1902603)2.50262686
111positive regulation of potassium ion transmembrane transport (GO:1901381)2.47661325
112regulation of early endosome to late endosome transport (GO:2000641)2.47130521
113synaptic vesicle exocytosis (GO:0016079)2.45695448
114gamma-aminobutyric acid transport (GO:0015812)2.45394388
115branched-chain amino acid metabolic process (GO:0009081)2.44384171
116cardiac muscle cell action potential involved in contraction (GO:0086002)2.44194292
117monocarboxylic acid catabolic process (GO:0072329)2.43750108
118C4-dicarboxylate transport (GO:0015740)2.43502388
119cardiac muscle cell action potential (GO:0086001)2.43494576
120oxaloacetate metabolic process (GO:0006107)2.42814413
121regulation of collagen metabolic process (GO:0010712)2.42531418
122fibrinolysis (GO:0042730)2.41867249
123regulation of synapse structural plasticity (GO:0051823)2.41720173
124collagen catabolic process (GO:0030574)2.41653458
125synaptic vesicle maturation (GO:0016188)2.39723983
126positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.39435311
127thioester biosynthetic process (GO:0035384)2.39403562
128acyl-CoA biosynthetic process (GO:0071616)2.39403562
129tooth mineralization (GO:0034505)2.39266339
130fructose metabolic process (GO:0006000)2.38903395
131endocytic recycling (GO:0032456)2.38666702
132regulation of membrane protein ectodomain proteolysis (GO:0051043)2.38045812
133chondroitin sulfate catabolic process (GO:0030207)2.37854737
134substrate-dependent cell migration (GO:0006929)2.37749512
135positive regulation of receptor recycling (GO:0001921)2.37231516
136negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.36602035
137positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.36421490
138vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.35862542
139activation of protein kinase A activity (GO:0034199)2.35655426
140kidney mesenchyme development (GO:0072074)2.35220849
141regulation of extracellular matrix organization (GO:1903053)2.35078940
142regulation of sodium ion transmembrane transport (GO:1902305)2.34737610
143regulation of cardiac muscle cell contraction (GO:0086004)2.34359037
144alpha-linolenic acid metabolic process (GO:0036109)2.34019388
145response to mercury ion (GO:0046689)2.33821869
146multicellular organismal macromolecule metabolic process (GO:0044259)2.32864847
147detection of calcium ion (GO:0005513)2.32829796
148positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.32634987
149relaxation of cardiac muscle (GO:0055119)2.32054101
150negative regulation of cytosolic calcium ion concentration (GO:0051481)2.31556735
151glutamate secretion (GO:0014047)2.31469891
152extracellular matrix disassembly (GO:0022617)2.31305805
153alanine transport (GO:0032328)2.30744580
154myofibril assembly (GO:0030239)2.30638939
155positive regulation of fibroblast migration (GO:0010763)2.29551060
156positive regulation of sodium ion transmembrane transport (GO:1902307)2.29519473
157platelet degranulation (GO:0002576)2.29272840
158negative regulation of smooth muscle cell migration (GO:0014912)2.28524061
159oxidative phosphorylation (GO:0006119)2.27516130
160regulation of sodium ion transmembrane transporter activity (GO:2000649)2.27364493
161response to laminar fluid shear stress (GO:0034616)2.26866594
162locomotory exploration behavior (GO:0035641)2.25442098
163multicellular organismal catabolic process (GO:0044243)2.25150682
164cellular response to vitamin (GO:0071295)2.23386586
165positive regulation of axon extension (GO:0045773)2.21752282
166multicellular organismal metabolic process (GO:0044236)2.21240168
167regulation of transforming growth factor beta1 production (GO:0032908)2.19894612
168chondrocyte proliferation (GO:0035988)2.19120385
169glycosphingolipid catabolic process (GO:0046479)2.18756598
170peptidyl-proline hydroxylation (GO:0019511)2.11239212
171negative regulation of protein localization to plasma membrane (GO:1903077)2.10575552
172response to fluid shear stress (GO:0034405)2.08928018
173positive regulation of blood vessel endothelial cell migration (GO:0043536)2.08917189
174vascular endothelial growth factor signaling pathway (GO:0038084)2.08424085
175fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.07673174
176positive regulation of endothelial cell apoptotic process (GO:2000353)2.07355393
177bone trabecula formation (GO:0060346)2.06950895
178positive regulation of collagen biosynthetic process (GO:0032967)2.04876610
179cellular response to nutrient (GO:0031670)2.04660548
180regulation of collagen biosynthetic process (GO:0032965)2.04621213
181metanephric mesenchyme development (GO:0072075)2.03935003
182peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.03471813
183negative regulation of focal adhesion assembly (GO:0051895)2.03147365
184negative regulation of cell junction assembly (GO:1901889)2.03147365
185negative regulation of adherens junction organization (GO:1903392)2.03147365
186negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.00757255
187chondroitin sulfate biosynthetic process (GO:0030206)1.99340379
188extracellular matrix organization (GO:0030198)1.99263038
189decidualization (GO:0046697)1.99208238
190negative regulation of complement activation (GO:0045916)1.98959982
191negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)1.98760597
192extracellular structure organization (GO:0043062)1.98339019
193cellular response to vascular endothelial growth factor stimulus (GO:0035924)1.97831627
194retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)1.96570065
195positive regulation of collagen metabolic process (GO:0010714)1.96055529
196heparan sulfate proteoglycan biosynthetic process (GO:0015012)1.95946450
197glycolipid catabolic process (GO:0019377)1.95633304
198negative regulation of protein activation cascade (GO:2000258)1.94857034
199glial cell migration (GO:0008347)1.94343396
200oligosaccharide catabolic process (GO:0009313)1.94247321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.50575683
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.81928767
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.07706120
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.59109584
5* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.53691284
6EZH2_22144423_ChIP-Seq_EOC_Human2.34627002
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.33458912
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.25680606
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24761581
10ZNF263_19887448_ChIP-Seq_K562_Human2.07146918
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05967074
12LXR_22158963_ChIP-Seq_LIVER_Mouse1.97722668
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.94752387
14* ELK3_25401928_ChIP-Seq_HUVEC_Human1.94462631
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89902697
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86336925
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.85754094
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84195936
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82191023
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.81482859
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.79288530
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75895419
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73190626
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71920918
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71805052
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70796059
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70796059
28DROSHA_22980978_ChIP-Seq_HELA_Human1.70783439
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.64915043
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64799628
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63430804
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61871403
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.61254056
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.59658558
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.57536904
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53407968
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51784239
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51436533
39REST_21632747_ChIP-Seq_MESCs_Mouse1.49767981
40* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49365832
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48257944
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46701615
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46275787
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.46084068
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44692498
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42137500
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.41313743
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39588617
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38349449
50* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38219857
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.37624905
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36790109
53CJUN_26792858_Chip-Seq_BT549_Human1.36315249
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.35361400
55CLOCK_20551151_ChIP-Seq_293T_Human1.34307159
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.29079284
57LXR_22292898_ChIP-Seq_THP-1_Human1.27625704
58NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26167752
59TBX20_22328084_ChIP-Seq_HEART_Mouse1.24660035
60TBX20_22080862_ChIP-Seq_HEART_Mouse1.24660035
61SMC1_22415368_ChIP-Seq_MEFs_Mouse1.24450109
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23934266
63* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23187439
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21868108
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21858865
66CTCF_27219007_Chip-Seq_Bcells_Human1.20449732
67SMC4_20622854_ChIP-Seq_HELA_Human1.17697517
68BRD4_25478319_ChIP-Seq_HGPS_Human1.17569068
69ZNF274_21170338_ChIP-Seq_K562_Hela1.17068829
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.16523179
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15267295
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14049888
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13021834
74TP53_22127205_ChIP-Seq_IMR90_Human1.12987073
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12725709
76TET1_21490601_ChIP-Seq_MESCs_Mouse1.10926195
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10603476
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.10418577
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10371044
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08657030
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08601745
82SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08193922
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07463944
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07306258
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06572046
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05377651
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02802244
88SOX2_20726797_ChIP-Seq_SW620_Human1.02723257
89FOXH1_21741376_ChIP-Seq_ESCs_Human1.02262678
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00820788
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00820788
92GBX2_23144817_ChIP-Seq_PC3_Human0.99844383
93SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99222669
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99058877
95P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98788146
96* KDM2B_26808549_Chip-Seq_DND41_Human0.97839862
97IRF8_27001747_Chip-Seq_BMDM_Mouse0.97292486
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97152912
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96958973
100TP63_22573176_ChIP-Seq_HFKS_Human0.96524321
101KLF4_19829295_ChIP-Seq_ESCs_Human0.96362870
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95218628
103EOMES_21245162_ChIP-Seq_HESCs_Human0.94825632
104TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94695527
105TP53_23651856_ChIP-Seq_MEFs_Mouse0.94545728
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94494628
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.93709758
108EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93225364
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92981144
110* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92952338
111IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92024456
112P68_20966046_ChIP-Seq_HELA_Human0.91670417
113* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90958193
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90927150
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90918952
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90005226
117GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89669556
118VDR_24787735_ChIP-Seq_THP-1_Human0.89561960
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88962478
120RACK7_27058665_Chip-Seq_MCF-7_Human0.87684697
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87476871
122GATA1_22025678_ChIP-Seq_K562_Human0.86412790
123* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85810264
124FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85703247
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85580360
126SA1_22415368_ChIP-Seq_MEFs_Mouse0.85413894
127TAF2_19829295_ChIP-Seq_ESCs_Human0.84293996
128* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82970331
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82148354
130RING1B_27294783_Chip-Seq_ESCs_Mouse0.81254950
131KDM2B_26808549_Chip-Seq_K562_Human0.80694823
132FOXA2_19822575_ChIP-Seq_HepG2_Human0.80275974
133SA1_27219007_Chip-Seq_Bcells_Human0.80131283
134ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79506891
135SOX2_21211035_ChIP-Seq_LN229_Gbm0.79064003
136TET1_21451524_ChIP-Seq_MESCs_Mouse0.78599291
137OCT4_19829295_ChIP-Seq_ESCs_Human0.77756981
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.77657023
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77598113
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77289766
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76413699
142TP53_20018659_ChIP-ChIP_R1E_Mouse0.75833587
143RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75427602
144CREB1_26743006_Chip-Seq_LNCaP_Human0.74827932
145CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74819783
146UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.74514165
147MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.72991871
148BCOR_27268052_Chip-Seq_Bcells_Human0.72639564
149GATA1_19941826_ChIP-Seq_K562_Human0.72465380
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72249594
151BCAT_22108803_ChIP-Seq_LS180_Human0.72237133
152ESR1_20079471_ChIP-ChIP_T-47D_Human0.71806552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.21022277
2MP0002837_dystrophic_cardiac_calcinosis4.45305313
3MP0003646_muscle_fatigue3.61073934
4MP0003705_abnormal_hypodermis_morpholog3.28895254
5MP0000751_myopathy3.25092321
6MP0004215_abnormal_myocardial_fiber3.10857173
7MP0004084_abnormal_cardiac_muscle3.01615218
8MP0005257_abnormal_intraocular_pressure2.78753129
9MP0005503_abnormal_tendon_morphology2.77985113
10MP0004272_abnormal_basement_membrane2.72905110
11MP0005275_abnormal_skin_tensile2.61874910
12MP0003329_amyloid_beta_deposits2.51983448
13MP0004036_abnormal_muscle_relaxation2.51652603
14MP0004859_abnormal_synaptic_plasticity2.44425848
15MP0004510_myositis2.39197260
16MP0004130_abnormal_muscle_cell2.34699392
17MP0005330_cardiomyopathy2.26725727
18MP0001542_abnormal_bone_strength2.25142125
19MP0006054_spinal_hemorrhage2.20469193
20MP0003172_abnormal_lysosome_physiology2.17607647
21MP0003300_gastrointestinal_ulcer2.08600861
22MP0000749_muscle_degeneration2.06486226
23MP0003566_abnormal_cell_adhesion2.03548524
24MP0003195_calcinosis1.94585409
25MP0000013_abnormal_adipose_tissue1.92907528
26MP0003137_abnormal_impulse_conducting1.90853854
27MP0004043_abnormal_pH_regulation1.90724189
28MP0009780_abnormal_chondrocyte_physiolo1.89778671
29MP0010368_abnormal_lymphatic_system1.88300987
30MP0003091_abnormal_cell_migration1.87142061
31MP0005332_abnormal_amino_acid1.85994787
32MP0002909_abnormal_adrenal_gland1.85916994
33MP0002295_abnormal_pulmonary_circulatio1.84267466
34* MP0009840_abnormal_foam_cell1.81865668
35MP0002972_abnormal_cardiac_muscle1.78182160
36MP0002139_abnormal_hepatobiliary_system1.73865922
37MP0005023_abnormal_wound_healing1.72257483
38MP0000747_muscle_weakness1.71553155
39MP0005670_abnormal_white_adipose1.68013774
40MP0003635_abnormal_synaptic_transmissio1.67383759
41MP0004270_analgesia1.62385632
42MP0005620_abnormal_muscle_contractility1.61157293
43MP0002269_muscular_atrophy1.60223970
44MP0000750_abnormal_muscle_regeneration1.54150777
45MP0000767_abnormal_smooth_muscle1.52337394
46MP0006036_abnormal_mitochondrial_physio1.51890814
47MP0005623_abnormal_meninges_morphology1.51733891
48MP0000343_altered_response_to1.50198079
49MP0004484_altered_response_of1.50028832
50MP0008775_abnormal_heart_ventricle1.49944306
51MP0004087_abnormal_muscle_fiber1.49896200
52MP0010386_abnormal_urinary_bladder1.48789959
53MP0006082_CNS_inflammation1.48325881
54MP0006138_congestive_heart_failure1.48059923
55MP0004858_abnormal_nervous_system1.46390509
56MP0003880_abnormal_central_pattern1.45432424
57MP0002064_seizures1.43814510
58MP0005385_cardiovascular_system_phenoty1.43009231
59MP0001544_abnormal_cardiovascular_syste1.43009231
60MP0002896_abnormal_bone_mineralization1.42515398
61MP0005360_urolithiasis1.40958784
62MP0008875_abnormal_xenobiotic_pharmacok1.40877576
63MP0004885_abnormal_endolymph1.39644765
64MP0002254_reproductive_system_inflammat1.39625823
65MP0005085_abnormal_gallbladder_physiolo1.38243246
66MP0009046_muscle_twitch1.36039607
67MP0004085_abnormal_heartbeat1.35960897
68MP0003690_abnormal_glial_cell1.35515073
69MP0005451_abnormal_body_composition1.32986520
70MP0001440_abnormal_grooming_behavior1.32321467
71MP0005058_abnormal_lysosome_morphology1.31721313
72MP0002998_abnormal_bone_remodeling1.31420475
73MP0001533_abnormal_skeleton_physiology1.29015060
74MP0005595_abnormal_vascular_smooth1.28912346
75MP0004145_abnormal_muscle_electrophysio1.27604897
76MP0005508_abnormal_skeleton_morphology1.27324572
77MP0005365_abnormal_bile_salt1.27094382
78MP0002822_catalepsy1.26550090
79MP0003950_abnormal_plasma_membrane1.26301021
80MP0003075_altered_response_to1.26298467
81MP0004233_abnormal_muscle_weight1.25557652
82MP0003011_delayed_dark_adaptation1.22050363
83MP0000604_amyloidosis1.19431486
84MP0002090_abnormal_vision1.18729711
85MP0005551_abnormal_eye_electrophysiolog1.17640001
86MP0005164_abnormal_response_to1.17237216
87MP0002063_abnormal_learning/memory/cond1.17129670
88* MP0002118_abnormal_lipid_homeostasis1.16510312
89MP0009745_abnormal_behavioral_response1.15963769
90MP0002272_abnormal_nervous_system1.15069320
91* MP0010329_abnormal_lipoprotein_level1.14485034
92MP0002106_abnormal_muscle_physiology1.13662368
93MP0003436_decreased_susceptibility_to1.13605342
94MP0003303_peritoneal_inflammation1.12939010
95MP0005390_skeleton_phenotype1.12205884
96MP0009384_cardiac_valve_regurgitation1.10928413
97MP0004924_abnormal_behavior1.08607360
98MP0005386_behavior/neurological_phenoty1.08607360
99MP0005666_abnormal_adipose_tissue1.08599458
100MP0005464_abnormal_platelet_physiology1.08402654
101MP0004019_abnormal_vitamin_homeostasis1.07957133
102MP0005535_abnormal_body_temperature1.07313436
103MP0003879_abnormal_hair_cell1.07044492
104MP0006035_abnormal_mitochondrial_morpho1.06683624
105MP0002060_abnormal_skin_morphology1.05385394
106MP0001243_abnormal_dermal_layer1.05100875
107MP0002877_abnormal_melanocyte_morpholog1.04184869
108MP0000230_abnormal_systemic_arterial1.03964111
109MP0002933_joint_inflammation1.02236964
110MP0001756_abnormal_urination1.00804161
111MP0005369_muscle_phenotype0.98241758
112MP0005584_abnormal_enzyme/coenzyme_acti0.97276213
113MP0008569_lethality_at_weaning0.96648213
114MP0002572_abnormal_emotion/affect_behav0.96050904
115MP0002734_abnormal_mechanical_nocicepti0.95876577
116MP0001486_abnormal_startle_reflex0.95529394
117MP0003283_abnormal_digestive_organ0.93531421
118MP0000920_abnormal_myelination0.93515250
119MP0002638_abnormal_pupillary_reflex0.93421842
120MP0005423_abnormal_somatic_nervous0.93186214
121MP0005377_hearing/vestibular/ear_phenot0.93007476
122MP0003878_abnormal_ear_physiology0.93007476
123MP0005646_abnormal_pituitary_gland0.92763352
124MP0010630_abnormal_cardiac_muscle0.92420241
125MP0003633_abnormal_nervous_system0.91704089
126MP0003868_abnormal_feces_composition0.91321163
127MP0002067_abnormal_sensory_capabilities0.91090837
128MP0008004_abnormal_stomach_pH0.90768353
129MP0000759_abnormal_skeletal_muscle0.90695304
130MP0003806_abnormal_nucleotide_metabolis0.89926989
131MP0003279_aneurysm0.89909244
132MP0003828_pulmonary_edema0.89766839
133MP0000003_abnormal_adipose_tissue0.89753531
134MP0005375_adipose_tissue_phenotype0.89338665
135MP0003191_abnormal_cellular_cholesterol0.88271965
136MP0009643_abnormal_urine_homeostasis0.86851607
137MP0009053_abnormal_anal_canal0.86676738
138MP0004883_abnormal_blood_vessel0.86157477
139MP0003795_abnormal_bone_structure0.85678811
140MP0002078_abnormal_glucose_homeostasis0.85124695
141MP0002332_abnormal_exercise_endurance0.84690535
142MP0001958_emphysema0.83878804
143MP0001984_abnormal_olfaction0.83243121
144MP0002876_abnormal_thyroid_physiology0.82198850
145MP0001502_abnormal_circadian_rhythm0.81946847
146MP0005165_increased_susceptibility_to0.81903862
147* MP0002229_neurodegeneration0.81784173
148MP0001849_ear_inflammation0.81763531
149MP0003045_fibrosis0.81312011
150MP0000534_abnormal_ureter_morphology0.81054467
151MP0002108_abnormal_muscle_morphology0.81054201
152MP0001299_abnormal_eye_distance/0.80473251
153* MP0003634_abnormal_glial_cell0.78529638
154MP0005166_decreased_susceptibility_to0.76513975
155MP0002168_other_aberrant_phenotype0.76369978
156MP0003448_altered_tumor_morphology0.75212146
157MP0001348_abnormal_lacrimal_gland0.73502732
158MP0000249_abnormal_blood_vessel0.73376213
159MP0000733_abnormal_muscle_development0.71652044
160MP0001915_intracranial_hemorrhage0.70974607
161MP0003724_increased_susceptibility_to0.70764056
162MP0000858_altered_metastatic_potential0.70351050
163MP0008260_abnormal_autophagy0.69514824
164MP0005409_darkened_coat_color0.69498654
165MP0000538_abnormal_urinary_bladder0.65341869
166MP0008874_decreased_physiological_sensi0.64777293
167MP0002419_abnormal_innate_immunity0.60396514
168MP0001614_abnormal_blood_vessel0.59979811
169MP0002128_abnormal_blood_circulation0.59812429
170MP0009764_decreased_sensitivity_to0.57909624
171MP0002971_abnormal_brown_adipose0.57689937
172MP0002089_abnormal_postnatal_growth/wei0.57302699

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.81599381
2Protrusio acetabuli (HP:0003179)5.77496241
3Sudden death (HP:0001699)3.88933252
4Ketoacidosis (HP:0001993)3.80883336
5Exercise-induced myalgia (HP:0003738)3.76946926
6Vertebral compression fractures (HP:0002953)3.68022182
7Bundle branch block (HP:0011710)3.58870582
8Ankle contracture (HP:0006466)3.55777717
9Vascular tortuosity (HP:0004948)3.53431415
10Atrioventricular block (HP:0001678)3.45501166
11Aortic dissection (HP:0002647)3.45463199
12Type 1 muscle fiber predominance (HP:0003803)3.42269490
13Dysostosis multiplex (HP:0000943)3.40449388
14Aortic aneurysm (HP:0004942)3.39877710
15Hyperglycinuria (HP:0003108)3.35245262
16Myoglobinuria (HP:0002913)3.30418459
17Ketosis (HP:0001946)3.21306150
18Follicular hyperkeratosis (HP:0007502)3.20916440
19Muscle fiber splitting (HP:0003555)3.18508870
20Urinary glycosaminoglycan excretion (HP:0003541)3.18453832
21Mucopolysacchariduria (HP:0008155)3.18453832
22Abnormality of mucopolysaccharide metabolism (HP:0011020)3.18275570
23Abnormality of polysaccharide metabolism (HP:0011012)3.18275570
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.18275570
25Cervical subluxation (HP:0003308)3.16591401
26Hypoglycemic coma (HP:0001325)3.14992133
27Heart block (HP:0012722)3.13587172
28Abnormality of glycine metabolism (HP:0010895)3.11688118
29Abnormality of serine family amino acid metabolism (HP:0010894)3.11688118
30Syncope (HP:0001279)3.11677471
31Abnormality of fatty-acid metabolism (HP:0004359)3.07354498
32Arterial tortuosity (HP:0005116)3.07252888
33Gout (HP:0001997)3.07044992
34Ventricular fibrillation (HP:0001663)3.06076716
35Peritonitis (HP:0002586)3.04141857
36Pheochromocytoma (HP:0002666)3.03568072
37Wormian bones (HP:0002645)2.98088919
38Spinal rigidity (HP:0003306)2.97590576
39Increased variability in muscle fiber diameter (HP:0003557)2.97046434
40Abnormal atrioventricular conduction (HP:0005150)2.94485480
41Slender build (HP:0001533)2.94423379
42Exercise-induced muscle cramps (HP:0003710)2.92725873
43Hyperglycinemia (HP:0002154)2.84128022
44Hepatic necrosis (HP:0002605)2.83805759
45Dicarboxylic aciduria (HP:0003215)2.83368435
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.83368435
47Hyperammonemia (HP:0001987)2.82844615
48Bladder diverticulum (HP:0000015)2.82275064
49Mitral stenosis (HP:0001718)2.81269380
50Calf muscle hypertrophy (HP:0008981)2.81169081
51Atrophic scars (HP:0001075)2.80713282
52Soft skin (HP:0000977)2.80665033
53Ventricular tachycardia (HP:0004756)2.80188004
54Abnormality of dentin (HP:0010299)2.78018226
55Systemic lupus erythematosus (HP:0002725)2.76544758
56Neuroendocrine neoplasm (HP:0100634)2.72931883
57Neurofibrillary tangles (HP:0002185)2.71129249
58Blue sclerae (HP:0000592)2.70161469
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69161691
60Abnormality of alanine metabolism (HP:0010916)2.69161691
61Hyperalaninemia (HP:0003348)2.69161691
62Spondylolisthesis (HP:0003302)2.66564514
63Genu recurvatum (HP:0002816)2.64392821
64Atrial fibrillation (HP:0005110)2.60791316
65Cerebral aneurysm (HP:0004944)2.56678506
66Fragile skin (HP:0001030)2.56491652
67Muscle hypertrophy of the lower extremities (HP:0008968)2.56020925
68Dilatation of the ascending aorta (HP:0005111)2.55946000
69Abnormality of skeletal muscle fiber size (HP:0012084)2.54115086
70Asymmetric septal hypertrophy (HP:0001670)2.53529609
71Palpitations (HP:0001962)2.52731266
72Abnormality of the calf musculature (HP:0001430)2.52479866
73Ventricular arrhythmia (HP:0004308)2.52349991
74Distal upper limb amyotrophy (HP:0007149)2.49667019
75Upper limb amyotrophy (HP:0009129)2.49667019
76Cardiovascular calcification (HP:0011915)2.49358276
77Joint stiffness (HP:0001387)2.46829035
78Primary atrial arrhythmia (HP:0001692)2.43982189
79Hepatocellular necrosis (HP:0001404)2.38874150
80Abnormal mitochondria in muscle tissue (HP:0008316)2.37954497
81Supraventricular tachycardia (HP:0004755)2.33595482
82Neonatal short-limb short stature (HP:0008921)2.33568743
83Cerebral inclusion bodies (HP:0100314)2.32391575
84Prolonged QT interval (HP:0001657)2.31987250
85Shallow orbits (HP:0000586)2.31584940
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31389286
87Hyporeflexia of lower limbs (HP:0002600)2.31383933
88Ovoid vertebral bodies (HP:0003300)2.30568518
89Acute encephalopathy (HP:0006846)2.30533354
90Mildly elevated creatine phosphokinase (HP:0008180)2.29922106
91Nuclear cataract (HP:0100018)2.28875065
92Supraventricular arrhythmia (HP:0005115)2.28206855
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.28122754
94Osteolytic defects of the hand bones (HP:0009699)2.28122754
95Visual hallucinations (HP:0002367)2.25303919
96Lethargy (HP:0001254)2.24886617
97Lipoatrophy (HP:0100578)2.24366630
98Acute necrotizing encephalopathy (HP:0006965)2.23587844
99Aneurysm (HP:0002617)2.22823868
100Abnormality of the Achilles tendon (HP:0005109)2.21712589
101Hyperextensible skin (HP:0000974)2.19299203
102Increased connective tissue (HP:0009025)2.17665151
103Achilles tendon contracture (HP:0001771)2.17587025
104Right ventricular cardiomyopathy (HP:0011663)2.17181730
105Cerebral edema (HP:0002181)2.14731915
106Wrist flexion contracture (HP:0001239)2.14299116
107Hand muscle atrophy (HP:0009130)2.13977027
108Supranuclear gaze palsy (HP:0000605)2.13346525
109Hypoventilation (HP:0002791)2.13223680
110Vacuolated lymphocytes (HP:0001922)2.12508678
111Difficulty running (HP:0009046)2.12413024
112Methylmalonic aciduria (HP:0012120)2.12398419
113* Athetosis (HP:0002305)2.11532134
114EMG: myopathic abnormalities (HP:0003458)2.08582091
115Dilated cardiomyopathy (HP:0001644)2.07942871
116Focal motor seizures (HP:0011153)2.07636216
117Abnormality of complement system (HP:0005339)2.07268281
118Mitral regurgitation (HP:0001653)2.06703306
119Generalized aminoaciduria (HP:0002909)2.06248473
120Vascular calcification (HP:0004934)2.05562652
121Myokymia (HP:0002411)2.05226447
122Lactic acidosis (HP:0003128)2.04659959
123Hyperinsulinemic hypoglycemia (HP:0000825)2.03694868
124Rhabdomyolysis (HP:0003201)2.02351779
125Biconcave vertebral bodies (HP:0004586)2.02183279
126Aplasia involving bones of the extremities (HP:0009825)2.00199897
127Aplasia involving bones of the upper limbs (HP:0009823)2.00199897
128Aplasia of the phalanges of the hand (HP:0009802)2.00199897
129Abnormal EKG (HP:0003115)1.99407696
130Bowel diverticulosis (HP:0005222)1.98285823
131Hyperglycemia (HP:0003074)1.98133034
132Deep venous thrombosis (HP:0002625)1.98026934
133Axonal loss (HP:0003447)1.97338164
134Increased muscle lipid content (HP:0009058)1.96589533
135Complement deficiency (HP:0004431)1.94762329
136Loss of speech (HP:0002371)1.94365383
137CNS demyelination (HP:0007305)1.94037960
138Difficulty climbing stairs (HP:0003551)1.93913330
139Mitochondrial inheritance (HP:0001427)1.93893947
140Aortic regurgitation (HP:0001659)1.93313038
141Global brain atrophy (HP:0002283)1.91815042
142Joint laxity (HP:0001388)1.91346559
143Increased CSF lactate (HP:0002490)1.90427939
144Abnormality of serum amino acid levels (HP:0003112)1.89855540
145Distal lower limb muscle weakness (HP:0009053)1.89709463
146Congenital glaucoma (HP:0001087)1.88866524
147Purpura (HP:0000979)1.88353295
148Myotonia (HP:0002486)1.88185653
149Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87697514
150Polycythemia (HP:0001901)1.86594737
151Generalized amyotrophy (HP:0003700)1.86070815
152Large for gestational age (HP:0001520)1.85620537
153Wide anterior fontanel (HP:0000260)1.84387654
154Abnormality of liposaccharide metabolism (HP:0010968)1.83715217
155Abnormality of glycosphingolipid metabolism (HP:0004343)1.83715217
156Abnormality of glycolipid metabolism (HP:0010969)1.83715217
157Left ventricular hypertrophy (HP:0001712)1.83645936
158Mitral valve prolapse (HP:0001634)1.83538635
159Metabolic acidosis (HP:0001942)1.83325034
160Progressive macrocephaly (HP:0004481)1.82597822
161Abnormality of the acetabulum (HP:0003170)1.82206341
162Elbow flexion contracture (HP:0002987)1.82068715
163Myocardial infarction (HP:0001658)1.81698572
164Ragged-red muscle fibers (HP:0003200)1.80955818
165Ankle clonus (HP:0011448)1.80832920
166Insulin-resistant diabetes mellitus (HP:0000831)1.80509896
167Abnormality of monocarboxylic acid metabolism (HP:0010996)1.80224432
168Osteoarthritis (HP:0002758)1.79631350
169Overgrowth (HP:0001548)1.79386223
170Respiratory failure (HP:0002878)1.78863694
171Nonimmune hydrops fetalis (HP:0001790)1.78400854
172Abnormal delivery (HP:0001787)1.77562954
173Generalized tonic-clonic seizures (HP:0002069)1.76521648
174Anxiety (HP:0000739)1.75801346
175J-shaped sella turcica (HP:0002680)1.75644086
176Increased circulating renin level (HP:0000848)1.75337408
177Central scotoma (HP:0000603)1.75246877
178Aortic valve stenosis (HP:0001650)1.74563620
179Increased cerebral lipofuscin (HP:0011813)1.74384768
180Long toe (HP:0010511)1.74047450
181Proximal tubulopathy (HP:0000114)1.73037567
182* Vomiting (HP:0002013)1.71975389
183Coxa vara (HP:0002812)1.71024838
184Broad metatarsal (HP:0001783)1.70274010
185Round ear (HP:0100830)1.67814500
186Obstructive sleep apnea (HP:0002870)1.67246988
187Thin bony cortex (HP:0002753)1.67108425
188Distal lower limb amyotrophy (HP:0008944)1.66395970
189Emphysema (HP:0002097)1.65610369
190Short nail (HP:0001799)1.64408451
191Hypoplasia of the iris (HP:0007676)1.63904172
192Amyloidosis (HP:0011034)1.63277330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK14.22969818
2PHKG23.17648619
3PHKG13.17648619
4BCKDK3.07975853
5TRIB32.91616385
6LMTK22.77470926
7PDK32.75737544
8PDK42.75737544
9PINK12.69235696
10DDR22.47387670
11TESK12.33224504
12EPHA42.22564385
13EPHA22.20161668
14TGFBR22.18713098
15MAP3K92.07857103
16PRKD22.01179773
17TTN1.98816162
18NEK11.93790258
19MAP3K31.82638547
20LIMK11.79110410
21PAK31.79067187
22PDK21.76666071
23PTK21.71532854
24MARK11.70833066
25MYLK1.69522847
26IRAK31.69315017
27EPHB21.68441715
28PRPF4B1.64701298
29EPHB11.60932575
30ARAF1.60737667
31NEK91.57944345
32PRKD31.54899379
33WNK41.50216854
34CAMKK21.49661635
35MOS1.47574863
36PAK61.44688503
37MAPK121.42810740
38NTRK31.40713494
39MUSK1.38743878
40NTRK11.38305299
41KSR21.35459725
42STK381.32166810
43MAP2K31.29064656
44TAOK21.27817401
45CAMK2D1.25810682
46ABL21.23402235
47MAP3K111.21270955
48SIK11.19757039
49PIM21.19465260
50OBSCN1.17261175
51ZAP701.13617798
52MINK11.11015430
53PIK3CG1.10789909
54TYK21.09693106
55MAP2K41.08563998
56SGK2231.08090844
57SGK4941.08090844
58CAMKK11.06802557
59TIE11.05242608
60PAK21.05071007
61TBK11.04850928
62PRKCG1.04782499
63CAMK2G1.04354719
64PNCK1.03893388
65MAP3K41.03721972
66DAPK21.03528857
67ICK1.03506445
68NTRK21.02695907
69PAK41.00996410
70PDPK10.99644033
71PTK2B0.97744086
72PRKG20.97467719
73OXSR10.95464556
74WNK30.95434140
75JAK10.90407606
76PKN20.89686169
77TRPM70.89362060
78FER0.89316097
79PRKCE0.88885119
80INSRR0.87719097
81TAOK10.87226683
82PRKD10.86990255
83CAMK2A0.86296328
84RPS6KA20.85391178
85MARK20.83682979
86ERN10.82316196
87FGFR40.81543568
88CAMK2B0.81356120
89PDGFRB0.79367956
90NME10.79283798
91CDK50.78532482
92CAMK10.78367858
93PRKAA10.77358648
94BRAF0.77145064
95GRK50.75864492
96PIK3CA0.75852189
97MAP2K70.75027318
98MAP2K10.74557095
99STK38L0.73194265
100DAPK30.71539258
101PRKCH0.71080236
102STK240.70074554
103LATS20.67375868
104STK390.63004005
105PTK60.62917014
106KDR0.62864238
107MAP3K10.59758528
108PDK10.58216786
109ROCK10.57872035
110JAK30.57612526
111ILK0.57258236
112DYRK1B0.57238744
113SGK30.56935618
114GSK3A0.56625775
115MAP3K130.55183173
116ADRBK10.55052372
117FGFR30.54384821
118MAP3K60.53881542
119MST1R0.53497326
120RET0.52860422
121BMX0.52730229
122HIPK20.51784348
123SGK20.50689950
124CDK190.50553537
125ROCK20.49276919
126PDGFRA0.48409603
127MAP3K120.48380334
128DMPK0.46548767
129TNIK0.45128464
130MAPKAPK50.44840348
131PRKACA0.44707333
132GRK70.44528134
133PRKACG0.44112511
134EPHA30.43677717
135CDK140.43572722
136CDC42BPA0.43333990
137KIT0.42726256
138MTOR0.42648779
139MAPK70.42511653
140MAP2K20.42129888
141AKT30.42032600
142BUB10.41302567
143FGFR20.40914946
144CDK150.40000588
145MAPKAPK30.39176008
146MAP3K70.38816961
147PRKCZ0.38609829
148MAP3K20.38380732
149MAP3K50.36878847
150CSK0.35820996
151MET0.35520001
152SRC0.34454996

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.68721009
2Other glycan degradation_Homo sapiens_hsa005113.34268658
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.19140142
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.02636961
5Propanoate metabolism_Homo sapiens_hsa006402.48118808
6Fatty acid degradation_Homo sapiens_hsa000712.40492018
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36021189
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28968793
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.26549523
10Nitrogen metabolism_Homo sapiens_hsa009102.25828057
11Butanoate metabolism_Homo sapiens_hsa006502.19122673
12Fatty acid metabolism_Homo sapiens_hsa012122.14935071
13Complement and coagulation cascades_Homo sapiens_hsa046102.13151434
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08534581
15Cardiac muscle contraction_Homo sapiens_hsa042602.02862187
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93619521
17ECM-receptor interaction_Homo sapiens_hsa045121.91939871
18Oxidative phosphorylation_Homo sapiens_hsa001901.89081496
19Carbon metabolism_Homo sapiens_hsa012001.77129931
20Parkinsons disease_Homo sapiens_hsa050121.67490450
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67326029
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62455821
23Focal adhesion_Homo sapiens_hsa045101.62119139
24Prion diseases_Homo sapiens_hsa050201.58426974
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52485637
26Fatty acid elongation_Homo sapiens_hsa000621.51180305
27Synaptic vesicle cycle_Homo sapiens_hsa047211.50936446
28Pyruvate metabolism_Homo sapiens_hsa006201.50907663
29Amoebiasis_Homo sapiens_hsa051461.44468321
30Arginine biosynthesis_Homo sapiens_hsa002201.37034863
31PPAR signaling pathway_Homo sapiens_hsa033201.36242136
32Alzheimers disease_Homo sapiens_hsa050101.31217813
33Dilated cardiomyopathy_Homo sapiens_hsa054141.31082635
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25601300
35GABAergic synapse_Homo sapiens_hsa047271.23962084
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22945004
37Peroxisome_Homo sapiens_hsa041461.20977722
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17752928
39Vitamin B6 metabolism_Homo sapiens_hsa007501.14160472
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.13034348
41Insulin secretion_Homo sapiens_hsa049111.12703443
42Tryptophan metabolism_Homo sapiens_hsa003801.11367791
43beta-Alanine metabolism_Homo sapiens_hsa004101.10631476
44Biosynthesis of amino acids_Homo sapiens_hsa012301.10461680
45Bile secretion_Homo sapiens_hsa049761.09985117
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09004509
47Protein digestion and absorption_Homo sapiens_hsa049741.08583010
48Collecting duct acid secretion_Homo sapiens_hsa049661.07779486
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.05763403
50Regulation of autophagy_Homo sapiens_hsa041401.05628010
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05098701
52Malaria_Homo sapiens_hsa051441.03336895
53Pertussis_Homo sapiens_hsa051331.01879924
54Nicotine addiction_Homo sapiens_hsa050331.01383337
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00661597
56Phagosome_Homo sapiens_hsa041451.00043384
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98608397
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98219382
59Proteoglycans in cancer_Homo sapiens_hsa052050.97760058
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97664696
61Osteoclast differentiation_Homo sapiens_hsa043800.97122433
62Fructose and mannose metabolism_Homo sapiens_hsa000510.94305764
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93913585
64Fatty acid biosynthesis_Homo sapiens_hsa000610.92993022
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91544947
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89536502
67Glycerolipid metabolism_Homo sapiens_hsa005610.89097019
68Huntingtons disease_Homo sapiens_hsa050160.87566196
69Caffeine metabolism_Homo sapiens_hsa002320.85688961
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85514629
71Gastric acid secretion_Homo sapiens_hsa049710.84811517
72Circadian entrainment_Homo sapiens_hsa047130.84793607
73Staphylococcus aureus infection_Homo sapiens_hsa051500.83466898
74Olfactory transduction_Homo sapiens_hsa047400.82999711
75Salivary secretion_Homo sapiens_hsa049700.82985059
76Arginine and proline metabolism_Homo sapiens_hsa003300.81804398
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81794208
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81615722
79* Sphingolipid metabolism_Homo sapiens_hsa006000.81328494
80Endocytosis_Homo sapiens_hsa041440.80740645
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78841028
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78132416
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76372232
84Sulfur metabolism_Homo sapiens_hsa009200.76110071
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.76088967
86Starch and sucrose metabolism_Homo sapiens_hsa005000.75324306
87TNF signaling pathway_Homo sapiens_hsa046680.75120579
88Morphine addiction_Homo sapiens_hsa050320.72453260
89Platelet activation_Homo sapiens_hsa046110.71473880
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71362451
91* Lysosome_Homo sapiens_hsa041420.69643130
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68908407
93Glutamatergic synapse_Homo sapiens_hsa047240.68768454
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68349412
95Circadian rhythm_Homo sapiens_hsa047100.67921059
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66463578
97GnRH signaling pathway_Homo sapiens_hsa049120.66200608
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.65774891
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65523944
100Vibrio cholerae infection_Homo sapiens_hsa051100.65131478
101Mineral absorption_Homo sapiens_hsa049780.65093961
102Bladder cancer_Homo sapiens_hsa052190.65055030
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.64950765
104Galactose metabolism_Homo sapiens_hsa000520.64159427
105Rheumatoid arthritis_Homo sapiens_hsa053230.63142579
106Glucagon signaling pathway_Homo sapiens_hsa049220.62718348
107Pentose phosphate pathway_Homo sapiens_hsa000300.62699091
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.62355875
109Vitamin digestion and absorption_Homo sapiens_hsa049770.62141823
110Salmonella infection_Homo sapiens_hsa051320.61230995
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60878126
112Calcium signaling pathway_Homo sapiens_hsa040200.60557585
113Phenylalanine metabolism_Homo sapiens_hsa003600.59298715
114Renin secretion_Homo sapiens_hsa049240.59215386
115Sulfur relay system_Homo sapiens_hsa041220.58023930
116VEGF signaling pathway_Homo sapiens_hsa043700.57682377
117Amphetamine addiction_Homo sapiens_hsa050310.57033003
118Tyrosine metabolism_Homo sapiens_hsa003500.55954145
119Toxoplasmosis_Homo sapiens_hsa051450.55424956
120Long-term potentiation_Homo sapiens_hsa047200.54872176
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54021619
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.53130091
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52791345
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52749940
125* Sphingolipid signaling pathway_Homo sapiens_hsa040710.52509402
126* Metabolic pathways_Homo sapiens_hsa011000.52359715
127Pancreatic secretion_Homo sapiens_hsa049720.52343288
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.52046761
129Insulin signaling pathway_Homo sapiens_hsa049100.51802227
130Fat digestion and absorption_Homo sapiens_hsa049750.51704682
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51494804
132Renin-angiotensin system_Homo sapiens_hsa046140.50623407
133Taste transduction_Homo sapiens_hsa047420.50620656
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49857371
135Tuberculosis_Homo sapiens_hsa051520.49454367
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47868708
137Shigellosis_Homo sapiens_hsa051310.47716442
138N-Glycan biosynthesis_Homo sapiens_hsa005100.46846912
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46786296
140Oxytocin signaling pathway_Homo sapiens_hsa049210.46438558
141Renal cell carcinoma_Homo sapiens_hsa052110.45486428
142Rap1 signaling pathway_Homo sapiens_hsa040150.45390475
143Cocaine addiction_Homo sapiens_hsa050300.45167801
144Folate biosynthesis_Homo sapiens_hsa007900.44538169
145Hepatitis C_Homo sapiens_hsa051600.43939921
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43812292
147Dopaminergic synapse_Homo sapiens_hsa047280.43654584
148Gap junction_Homo sapiens_hsa045400.43636122
149Retinol metabolism_Homo sapiens_hsa008300.43282738
150Insulin resistance_Homo sapiens_hsa049310.42651591
151Estrogen signaling pathway_Homo sapiens_hsa049150.42539578
152Type II diabetes mellitus_Homo sapiens_hsa049300.41815696
153Thyroid hormone synthesis_Homo sapiens_hsa049180.40921614
154Chronic myeloid leukemia_Homo sapiens_hsa052200.40305953
155AMPK signaling pathway_Homo sapiens_hsa041520.40238288
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.39705747
157Chemical carcinogenesis_Homo sapiens_hsa052040.39281202
158Histidine metabolism_Homo sapiens_hsa003400.38832649
159Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38705931
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38680909
161Cholinergic synapse_Homo sapiens_hsa047250.37989198
162Glioma_Homo sapiens_hsa052140.37960232
163Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36937081
164Steroid hormone biosynthesis_Homo sapiens_hsa001400.36841390

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