SMIM9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.02203674
2folic acid metabolic process (GO:0046655)4.95445700
3mitotic metaphase plate congression (GO:0007080)4.80714972
4folic acid transport (GO:0015884)4.70732022
5serine family amino acid catabolic process (GO:0009071)4.31736372
6glycine metabolic process (GO:0006544)4.23802160
7ribosome assembly (GO:0042255)4.17469846
8intestinal epithelial cell development (GO:0060576)4.12732446
9ribosome biogenesis (GO:0042254)4.09476463
10synaptonemal complex assembly (GO:0007130)4.05061106
11nucleobase biosynthetic process (GO:0046112)4.04272822
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.02180568
13fructose metabolic process (GO:0006000)3.96541486
14rRNA modification (GO:0000154)3.88246796
157-methylguanosine mRNA capping (GO:0006370)3.86748510
16histone-serine phosphorylation (GO:0035404)3.81957665
17biotin metabolic process (GO:0006768)3.79584987
18lung-associated mesenchyme development (GO:0060484)3.79410502
19regulation of spindle organization (GO:0090224)3.77485719
20DNA replication checkpoint (GO:0000076)3.71015015
217-methylguanosine RNA capping (GO:0009452)3.67854520
22RNA capping (GO:0036260)3.67854520
23cysteine metabolic process (GO:0006534)3.65236099
24synaptonemal complex organization (GO:0070193)3.62585066
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.61598971
26serine family amino acid metabolic process (GO:0009069)3.58408234
27meiosis I (GO:0007127)3.56601512
28positive regulation of chromosome segregation (GO:0051984)3.55468994
29metaphase plate congression (GO:0051310)3.54376626
30labyrinthine layer development (GO:0060711)3.51872512
31histone exchange (GO:0043486)3.50046883
32termination of RNA polymerase I transcription (GO:0006363)3.47888825
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45675170
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.45029029
35termination of RNA polymerase III transcription (GO:0006386)3.45029029
36G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.40023081
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36945487
38serine family amino acid biosynthetic process (GO:0009070)3.36448996
39transcription elongation from RNA polymerase I promoter (GO:0006362)3.35884901
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.35773728
41male meiosis I (GO:0007141)3.35173763
42S-adenosylmethionine metabolic process (GO:0046500)3.29536063
43cell wall macromolecule metabolic process (GO:0044036)3.29297283
44cell wall macromolecule catabolic process (GO:0016998)3.29297283
45amino acid salvage (GO:0043102)3.28186937
46L-methionine salvage (GO:0071267)3.28186937
47L-methionine biosynthetic process (GO:0071265)3.28186937
48pyrimidine-containing compound transmembrane transport (GO:0072531)3.25198181
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23827829
50transcription from RNA polymerase I promoter (GO:0006360)3.16427882
51blastocyst development (GO:0001824)3.15499662
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13747308
53fusion of sperm to egg plasma membrane (GO:0007342)3.13033200
54regulation of mitotic spindle organization (GO:0060236)3.11458623
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10555538
56CENP-A containing nucleosome assembly (GO:0034080)3.06259117
57vitamin transmembrane transport (GO:0035461)3.02978622
58modified amino acid transport (GO:0072337)3.01376383
59negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.01296148
60positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.00990920
61autophagic vacuole assembly (GO:0000045)2.99316620
62positive regulation of ligase activity (GO:0051351)2.96932668
63regulation of cellular amino acid metabolic process (GO:0006521)2.95623516
64rRNA methylation (GO:0031167)2.95400056
65L-serine metabolic process (GO:0006563)2.95263805
66sulfur amino acid biosynthetic process (GO:0000097)2.95056380
67regulation of chromosome segregation (GO:0051983)2.93986759
68protein localization to kinetochore (GO:0034501)2.91480730
69transcription from mitochondrial promoter (GO:0006390)2.89507034
70ribonucleoprotein complex biogenesis (GO:0022613)2.88561196
71transcription initiation from RNA polymerase I promoter (GO:0006361)2.88132643
72alditol metabolic process (GO:0019400)2.87137340
73triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.85792495
74microtubule depolymerization (GO:0007019)2.84398248
75cofactor transport (GO:0051181)2.83849081
76chromatin remodeling at centromere (GO:0031055)2.83280629
77urate metabolic process (GO:0046415)2.82965752
78sperm motility (GO:0030317)2.82927140
79spindle checkpoint (GO:0031577)2.82682380
80single strand break repair (GO:0000012)2.81732317
81establishment of chromosome localization (GO:0051303)2.80964852
82polyamine biosynthetic process (GO:0006596)2.80909778
83pantothenate metabolic process (GO:0015939)2.80865011
84piRNA metabolic process (GO:0034587)2.79320455
85proteasome assembly (GO:0043248)2.77589462
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76982186
87negative regulation of ligase activity (GO:0051352)2.76982186
88homocysteine metabolic process (GO:0050667)2.76175017
89heme transport (GO:0015886)2.76111220
90formation of translation preinitiation complex (GO:0001731)2.75302130
91regulation of ubiquitin-protein transferase activity (GO:0051438)2.74089178
92CDP-diacylglycerol metabolic process (GO:0046341)2.73784570
93sulfur amino acid catabolic process (GO:0000098)2.73452952
94positive regulation of viral transcription (GO:0050434)2.73433185
95transcription elongation from RNA polymerase II promoter (GO:0006368)2.73162705
96regulation of exit from mitosis (GO:0007096)2.72698257
97reciprocal DNA recombination (GO:0035825)2.71925716
98reciprocal meiotic recombination (GO:0007131)2.71925716
99amino sugar catabolic process (GO:0046348)2.71557614
100methionine metabolic process (GO:0006555)2.69898728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.66873556
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.46255019
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.20278795
4CREB1_15753290_ChIP-ChIP_HEK293T_Human3.43594488
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27793913
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.11171023
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.05938100
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.04566276
9AR_21909140_ChIP-Seq_LNCAP_Human2.93284390
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92493046
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.74684843
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.74184264
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.61521584
14KAP1_22055183_ChIP-Seq_ESCs_Mouse2.53491919
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35244814
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.34455642
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30894506
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22774952
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12780556
20VDR_23849224_ChIP-Seq_CD4+_Human2.06164711
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04786521
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04732169
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00445515
24ZNF263_19887448_ChIP-Seq_K562_Human1.96577572
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.96502381
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.95877075
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.94958179
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93859672
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87264046
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87003754
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.82359719
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79972924
33E2F7_22180533_ChIP-Seq_HELA_Human1.72181820
34NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.70470690
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69154172
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60787099
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60233515
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59312750
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58329195
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58057627
41GABP_19822575_ChIP-Seq_HepG2_Human1.57569790
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46888870
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.41262030
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40392503
45XRN2_22483619_ChIP-Seq_HELA_Human1.39860894
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28839056
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.28538233
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.28265795
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25238065
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24733658
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.23739034
52FOXP3_21729870_ChIP-Seq_TREG_Human1.22839139
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21652808
54DCP1A_22483619_ChIP-Seq_HELA_Human1.21578213
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19931164
56CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19639110
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17780068
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.16378099
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.16111057
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11656568
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10933000
62HTT_18923047_ChIP-ChIP_STHdh_Human1.09682827
63NANOG_18692474_ChIP-Seq_MEFs_Mouse1.07271841
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06796090
65KDM5A_27292631_Chip-Seq_BREAST_Human1.06770422
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06468286
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06384475
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.05671328
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.04599176
70NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00592217
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00088956
72PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98994588
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97296502
74SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96070335
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95183703
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94881655
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94657150
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94536969
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91348254
80SOX17_20123909_ChIP-Seq_XEN_Mouse0.89801424
81TTF2_22483619_ChIP-Seq_HELA_Human0.89552099
82SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85482952
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85185166
84E2F1_21310950_ChIP-Seq_MCF-7_Human0.85129533
85TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.84864837
86POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84649306
87ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80759994
88KAP1_27257070_Chip-Seq_ESCs_Mouse0.80301906
89PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79177719
90STAT1_17558387_ChIP-Seq_HELA_Human0.79012408
91RARB_24833708_ChIP-Seq_LIVER_Mouse0.78803451
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78750369
93CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77746248
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77580111
95OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77394875
96NANOG_16518401_ChIP-PET_MESCs_Mouse0.77138673
97TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77076360
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.76817056
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76198650
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.75779748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.61332229
2MP0003718_maternal_effect4.12664885
3MP0009840_abnormal_foam_cell3.79748450
4MP0003111_abnormal_nucleus_morphology3.62556275
5MP0005360_urolithiasis3.61413405
6MP0005085_abnormal_gallbladder_physiolo3.38498821
7MP0002139_abnormal_hepatobiliary_system3.32842387
8MP0004957_abnormal_blastocyst_morpholog3.26577899
9MP0003806_abnormal_nucleotide_metabolis3.07658344
10MP0000383_abnormal_hair_follicle2.94019383
11MP0005451_abnormal_body_composition2.93246547
12MP0005365_abnormal_bile_salt2.85227731
13MP0008260_abnormal_autophagy2.72075757
14MP0005410_abnormal_fertilization2.43365177
15MP0005332_abnormal_amino_acid2.31932421
16MP0010678_abnormal_skin_adnexa2.31866656
17MP0004019_abnormal_vitamin_homeostasis2.19373451
18MP0003077_abnormal_cell_cycle2.15283055
19MP0008875_abnormal_xenobiotic_pharmacok2.14019174
20MP0003195_calcinosis2.00559062
21MP0001929_abnormal_gametogenesis1.96755459
22MP0005670_abnormal_white_adipose1.94250739
23MP0005408_hypopigmentation1.93074364
24MP0010094_abnormal_chromosome_stability1.92395241
25MP0004130_abnormal_muscle_cell1.91735208
26MP0008057_abnormal_DNA_replication1.88870043
27MP0008877_abnormal_DNA_methylation1.88524556
28MP0005395_other_phenotype1.72145981
29MP0010329_abnormal_lipoprotein_level1.65219180
30MP0003656_abnormal_erythrocyte_physiolo1.61756945
31MP0000465_gastrointestinal_hemorrhage1.56736746
32MP0008058_abnormal_DNA_repair1.56442570
33MP0001730_embryonic_growth_arrest1.55224239
34MP0002210_abnormal_sex_determination1.51544781
35MP0001764_abnormal_homeostasis1.51069780
36MP0003698_abnormal_male_reproductive1.50248551
37MP0003950_abnormal_plasma_membrane1.47485430
38MP0001661_extended_life_span1.44760674
39MP0008932_abnormal_embryonic_tissue1.43335956
40MP0004185_abnormal_adipocyte_glucose1.41256701
41MP0003646_muscle_fatigue1.39989480
42MP0003786_premature_aging1.36001068
43MP0001145_abnormal_male_reproductive1.33837849
44MP0010307_abnormal_tumor_latency1.31704795
45MP0003186_abnormal_redox_activity1.31660319
46MP0000653_abnormal_sex_gland1.28725679
47MP0003315_abnormal_perineum_morphology1.28535382
48MP0006035_abnormal_mitochondrial_morpho1.24785888
49MP0000609_abnormal_liver_physiology1.21215517
50MP0003828_pulmonary_edema1.20264123
51MP0001756_abnormal_urination1.19224723
52MP0002118_abnormal_lipid_homeostasis1.16927918
53MP0002161_abnormal_fertility/fecundity1.13198547
54MP0005319_abnormal_enzyme/_coenzyme1.09207794
55MP0008007_abnormal_cellular_replicative1.06045903
56MP0000350_abnormal_cell_proliferation1.05331076
57MP0001666_abnormal_nutrient_absorption1.02685849
58MP0001697_abnormal_embryo_size1.02056908
59MP0005666_abnormal_adipose_tissue1.01733649
60MP0005380_embryogenesis_phenotype1.01030372
61MP0001672_abnormal_embryogenesis/_devel1.01030372
62MP0005389_reproductive_system_phenotype1.00666723
63MP0003699_abnormal_female_reproductive0.98038724
64MP0009643_abnormal_urine_homeostasis0.97997629
65MP0003724_increased_susceptibility_to0.97464709
66MP0000647_abnormal_sebaceous_gland0.96668373
67MP0006036_abnormal_mitochondrial_physio0.94739487
68MP0002080_prenatal_lethality0.89999080
69MP0001542_abnormal_bone_strength0.85968923
70MP0000358_abnormal_cell_content/0.84412783
71MP0003221_abnormal_cardiomyocyte_apopto0.84306001
72MP0000598_abnormal_liver_morphology0.83582725
73MP0004043_abnormal_pH_regulation0.81806636
74MP0003938_abnormal_ear_development0.81346578
75MP0002086_abnormal_extraembryonic_tissu0.81250105
76MP0003123_paternal_imprinting0.79013019
77MP0001545_abnormal_hematopoietic_system0.76400926
78MP0005397_hematopoietic_system_phenotyp0.76400926
79MP0001119_abnormal_female_reproductive0.72599883
80MP0002088_abnormal_embryonic_growth/wei0.72415540
81MP0006292_abnormal_olfactory_placode0.72320587
82MP0002102_abnormal_ear_morphology0.72132730
83MP0005636_abnormal_mineral_homeostasis0.71534792
84MP0004084_abnormal_cardiac_muscle0.69173333
85MP0003984_embryonic_growth_retardation0.68976131
86MP0005084_abnormal_gallbladder_morpholo0.65655155
87MP0003937_abnormal_limbs/digits/tail_de0.65116454
88MP0009697_abnormal_copulation0.64824721
89MP0006138_congestive_heart_failure0.64430924
90MP0002160_abnormal_reproductive_system0.64400504
91MP0005377_hearing/vestibular/ear_phenot0.63874841
92MP0003878_abnormal_ear_physiology0.63874841
93MP0005376_homeostasis/metabolism_phenot0.63831658
94MP0003941_abnormal_skin_development0.61867601
95MP0002653_abnormal_ependyma_morphology0.61598702
96MP0002085_abnormal_embryonic_tissue0.61565213
97MP0003329_amyloid_beta_deposits0.58612819
98MP0003252_abnormal_bile_duct0.57716695
99MP0002084_abnormal_developmental_patter0.57158494
100MP0000313_abnormal_cell_death0.54720773

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)7.11621099
2Abnormality of glycine metabolism (HP:0010895)6.06574309
3Abnormality of serine family amino acid metabolism (HP:0010894)6.06574309
4Hyperglycinemia (HP:0002154)5.75236463
5Spontaneous abortion (HP:0005268)4.40447561
6Hyperlipoproteinemia (HP:0010980)4.17293319
7Abnormal spermatogenesis (HP:0008669)4.12971407
8Onycholysis (HP:0001806)4.05246984
9Birth length less than 3rd percentile (HP:0003561)4.03883835
10Breast hypoplasia (HP:0003187)3.91557630
11Gout (HP:0001997)3.89027456
12Abnormality of serum amino acid levels (HP:0003112)3.85473861
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.35804022
14Impulsivity (HP:0100710)3.30086678
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.24833126
16Cerebral hypomyelination (HP:0006808)3.24408538
17Hyperammonemia (HP:0001987)3.21632734
18Xanthomatosis (HP:0000991)3.15254838
19Nausea (HP:0002018)3.03642957
20Carpal bone hypoplasia (HP:0001498)2.94343340
21Seborrheic dermatitis (HP:0001051)2.91193634
22Azoospermia (HP:0000027)2.87973367
23Ureteral duplication (HP:0000073)2.87470001
24Prolonged neonatal jaundice (HP:0006579)2.82593566
25Glucose intolerance (HP:0000833)2.80250344
26Ileus (HP:0002595)2.76318500
27Hypobetalipoproteinemia (HP:0003563)2.74578399
28Rough bone trabeculation (HP:0100670)2.69538667
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.69346595
30Hypoalphalipoproteinemia (HP:0003233)2.63503556
31Secondary amenorrhea (HP:0000869)2.63058143
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.62819422
33Lethargy (HP:0001254)2.62731704
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.59764059
35Absent/shortened dynein arms (HP:0200106)2.59181113
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.59181113
37Patellar aplasia (HP:0006443)2.58138826
38Abnormality of the umbilical cord (HP:0010881)2.56773041
39Hypolipoproteinemia (HP:0010981)2.56485869
40Dicarboxylic aciduria (HP:0003215)2.55334036
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55334036
42Hyperglycemia (HP:0003074)2.52895172
43Aplasia/Hypoplasia of the patella (HP:0006498)2.52813748
44Pelvic girdle muscle weakness (HP:0003749)2.49408861
45CNS hypomyelination (HP:0003429)2.47183528
46Chronic bronchitis (HP:0004469)2.44673336
47Premature ovarian failure (HP:0008209)2.42029230
48Death in infancy (HP:0001522)2.37470499
49Prolonged partial thromboplastin time (HP:0003645)2.36291675
50Capillary hemangiomas (HP:0005306)2.33601918
51Shoulder girdle muscle weakness (HP:0003547)2.31154517
52Hyperuricemia (HP:0002149)2.30761132
53Increased purine levels (HP:0004368)2.30761132
54Multiple enchondromatosis (HP:0005701)2.30745255
55Abnormality of alanine metabolism (HP:0010916)2.27780335
56Hyperalaninemia (HP:0003348)2.27780335
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27780335
58Abnormal delivery (HP:0001787)2.27655487
59Spastic paraparesis (HP:0002313)2.27522119
60Deep venous thrombosis (HP:0002625)2.27413524
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26773899
62Entropion (HP:0000621)2.25872051
63Atrioventricular block (HP:0001678)2.25519897
64Megaloblastic anemia (HP:0001889)2.21337025
65Tetraplegia (HP:0002445)2.15958988
66Male infertility (HP:0003251)2.14610744
67Ketosis (HP:0001946)2.10952198
68Intrahepatic cholestasis (HP:0001406)2.10581110
69Oral leukoplakia (HP:0002745)2.08875849
70Ketoacidosis (HP:0001993)2.07340687
71Abnormality of the hip-girdle musculature (HP:0001445)2.05322371
72Abnormality of the musculature of the pelvis (HP:0001469)2.05322371
73Proximal tubulopathy (HP:0000114)2.05181596
74Pancreatic fibrosis (HP:0100732)2.01435447
75Conjunctival telangiectasia (HP:0000524)2.00868029
76Abnormal glucose tolerance (HP:0001952)2.00281886
77Anorexia (HP:0002039)1.99445559
78Oligodactyly (hands) (HP:0001180)1.98922716
79Polycythemia (HP:0001901)1.98677156
80Irritability (HP:0000737)1.98020019
81Abnormality of fatty-acid metabolism (HP:0004359)1.96056188
82Epidermoid cyst (HP:0200040)1.95205072
83Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93841659
84Abnormality of the labia minora (HP:0012880)1.92344358
85Bundle branch block (HP:0011710)1.92216782
86Abnormal trabecular bone morphology (HP:0100671)1.91687080
87Abnormality of purine metabolism (HP:0004352)1.90580506
88Difficulty climbing stairs (HP:0003551)1.89544026
89Delusions (HP:0000746)1.89137219
90Progressive muscle weakness (HP:0003323)1.86873574
91Absent radius (HP:0003974)1.86347873
92Brittle hair (HP:0002299)1.85555146
93Insulin-resistant diabetes mellitus (HP:0000831)1.84928130
94Complement deficiency (HP:0004431)1.84576907
95CNS demyelination (HP:0007305)1.83596496
96Aplasia/Hypoplasia involving the musculature (HP:0001460)1.82815849
97Abnormality of sulfur amino acid metabolism (HP:0004339)1.81171918
98Gonadotropin excess (HP:0000837)1.80221607
99Abnormality of nucleobase metabolism (HP:0010932)1.80167878
100Microvesicular hepatic steatosis (HP:0001414)1.79443021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.78029124
2PDK44.78029124
3WEE14.66311992
4BUB14.13341626
5EPHA23.33425620
6PDK23.30112724
7EIF2AK13.15654739
8NEK12.92996123
9NME22.45196997
10PLK42.36519704
11PNCK2.21184628
12NEK22.16663081
13TTK2.12462924
14ARAF2.12186242
15BRSK21.99536407
16SRPK11.84800415
17TSSK61.71250860
18PLK11.70071242
19STK161.69517450
20ZAK1.64226000
21LATS21.63793079
22PLK31.63198613
23AKT31.59895183
24DYRK31.57302744
25BRAF1.47038228
26PINK11.37987114
27CHEK21.36370560
28CCNB11.32750011
29STK38L1.29383751
30MAP3K91.24287666
31CDK81.24013530
32CDC71.16183099
33EIF2AK31.15915327
34AURKB1.15649761
35BRSK11.11967322
36IRAK31.05218039
37MKNK21.01859300
38MET0.98934406
39AURKA0.98403146
40NME10.95155696
41RPS6KB20.92753461
42MAPK110.88600141
43MARK30.82977975
44STK30.77628131
45DYRK20.75510003
46RAF10.72529364
47TIE10.71216664
48TEC0.70709927
49ACVR1B0.70294610
50CDK40.67043437
51MKNK10.65200886
52CDK70.62742076
53BCKDK0.62492119
54MST40.59921912
55ABL20.54869098
56CSNK1E0.54119013
57PDK10.53395712
58FGFR40.50526319
59PAK10.49904648
60CDK30.49803690
61MAP3K80.49157456
62CHEK10.49033709
63MAPKAPK30.49030594
64CSNK2A10.48027583
65LATS10.43875701
66CSNK1G30.43333721
67PDPK10.42975190
68CDK20.42531998
69CSNK1G20.42502978
70ERBB20.42269059
71STK380.41077816
72CSF1R0.39258213
73MELK0.38083200
74CSNK1G10.37573972
75MAP3K130.36473975
76ALK0.36452292
77PRKCI0.34602981
78CSNK2A20.34491257
79IRAK10.33907766
80KSR20.31897624
81CDK10.31773415
82PRKCG0.31460685
83VRK10.30884730
84CAMK2G0.30847474
85MOS0.28942960
86PRKAA10.28566485
87EIF2AK20.28551222
88CAMKK20.28474337
89KDR0.27497872
90IRAK20.26458708
91ATR0.25273534
92RPS6KA50.25060850
93PIM20.23950671
94PRKCZ0.22318258
95DAPK10.19755076
96ATM0.19281631
97NUAK10.17258318
98FES0.16677714
99TESK20.16472187
100MAP2K20.15847281

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.67355489
2RNA polymerase_Homo sapiens_hsa030203.35230151
3Proteasome_Homo sapiens_hsa030503.16107154
4Regulation of autophagy_Homo sapiens_hsa041402.86466814
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79411880
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.72159014
7Folate biosynthesis_Homo sapiens_hsa007902.33570025
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.31818469
9RNA transport_Homo sapiens_hsa030132.20111421
10Pyrimidine metabolism_Homo sapiens_hsa002401.99193214
11Pentose phosphate pathway_Homo sapiens_hsa000301.95537396
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.84891460
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.84478253
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.80877648
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.79705959
16Basal transcription factors_Homo sapiens_hsa030221.74761191
17Cell cycle_Homo sapiens_hsa041101.69190702
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57848718
19Nitrogen metabolism_Homo sapiens_hsa009101.57431107
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55854479
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55472828
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51331519
23Ribosome_Homo sapiens_hsa030101.45969728
24Arginine biosynthesis_Homo sapiens_hsa002201.44969216
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40972740
26Caffeine metabolism_Homo sapiens_hsa002321.40527652
27PPAR signaling pathway_Homo sapiens_hsa033201.39504144
28Selenocompound metabolism_Homo sapiens_hsa004501.39258701
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36907085
30Nucleotide excision repair_Homo sapiens_hsa034201.34664341
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30936703
32Vitamin digestion and absorption_Homo sapiens_hsa049771.30532742
33Carbon metabolism_Homo sapiens_hsa012001.26812229
34Spliceosome_Homo sapiens_hsa030401.25573289
35beta-Alanine metabolism_Homo sapiens_hsa004101.24877684
36Biosynthesis of amino acids_Homo sapiens_hsa012301.24324479
37Propanoate metabolism_Homo sapiens_hsa006401.23897662
38Glutathione metabolism_Homo sapiens_hsa004801.22967115
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.21877159
40Peroxisome_Homo sapiens_hsa041461.21816178
41Purine metabolism_Homo sapiens_hsa002301.20911737
42Butanoate metabolism_Homo sapiens_hsa006501.16009174
43Oocyte meiosis_Homo sapiens_hsa041141.14085359
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11083570
45Fructose and mannose metabolism_Homo sapiens_hsa000511.08979436
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07784026
47p53 signaling pathway_Homo sapiens_hsa041151.00540732
48Retinol metabolism_Homo sapiens_hsa008300.99405840
49Chemical carcinogenesis_Homo sapiens_hsa052040.99302748
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97437098
51Fatty acid degradation_Homo sapiens_hsa000710.97168110
52Homologous recombination_Homo sapiens_hsa034400.96226146
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95665052
54DNA replication_Homo sapiens_hsa030300.95460442
55Arginine and proline metabolism_Homo sapiens_hsa003300.93679671
56Base excision repair_Homo sapiens_hsa034100.92379786
57Sulfur relay system_Homo sapiens_hsa041220.89282573
58Histidine metabolism_Homo sapiens_hsa003400.88490101
59Tryptophan metabolism_Homo sapiens_hsa003800.87159514
60Glycerolipid metabolism_Homo sapiens_hsa005610.84003199
61Complement and coagulation cascades_Homo sapiens_hsa046100.83696560
62mRNA surveillance pathway_Homo sapiens_hsa030150.82145358
63Linoleic acid metabolism_Homo sapiens_hsa005910.81484588
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80276048
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77952950
66Metabolic pathways_Homo sapiens_hsa011000.75882224
67Fatty acid elongation_Homo sapiens_hsa000620.75488963
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74929232
69Fat digestion and absorption_Homo sapiens_hsa049750.73685980
70Fatty acid metabolism_Homo sapiens_hsa012120.72571619
71Phenylalanine metabolism_Homo sapiens_hsa003600.72487059
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71714250
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66175691
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64785978
75Pyruvate metabolism_Homo sapiens_hsa006200.64120706
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.60908218
77Mismatch repair_Homo sapiens_hsa034300.59590162
78Fanconi anemia pathway_Homo sapiens_hsa034600.59307692
79Arachidonic acid metabolism_Homo sapiens_hsa005900.57105586
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56386079
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56015481
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55530167
83Huntingtons disease_Homo sapiens_hsa050160.53610617
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.52254019
85Bile secretion_Homo sapiens_hsa049760.50173524
86Sulfur metabolism_Homo sapiens_hsa009200.49216665
87RNA degradation_Homo sapiens_hsa030180.48763822
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47928256
89Epstein-Barr virus infection_Homo sapiens_hsa051690.46661808
90Tyrosine metabolism_Homo sapiens_hsa003500.39794226
91Staphylococcus aureus infection_Homo sapiens_hsa051500.37337813
92Circadian rhythm_Homo sapiens_hsa047100.36549960
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31155233
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28324806
95Ether lipid metabolism_Homo sapiens_hsa005650.27915201
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27439718
97One carbon pool by folate_Homo sapiens_hsa006700.26949886
98Mineral absorption_Homo sapiens_hsa049780.26308590
99Prion diseases_Homo sapiens_hsa050200.24743320
100ABC transporters_Homo sapiens_hsa020100.19550410

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