SMIM23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.92344742
2axonemal dynein complex assembly (GO:0070286)9.81674814
3reproduction (GO:0000003)9.39390326
4motile cilium assembly (GO:0044458)9.17030020
5regulation of cilium movement (GO:0003352)8.75202195
6cilium or flagellum-dependent cell motility (GO:0001539)8.50211585
7cilium movement (GO:0003341)8.07761413
8single fertilization (GO:0007338)7.40033204
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.35756642
10sperm capacitation (GO:0048240)7.24462102
11negative regulation of inclusion body assembly (GO:0090084)7.17045795
12synaptonemal complex organization (GO:0070193)6.93942780
13spermatogenesis (GO:0007283)6.87497039
14male gamete generation (GO:0048232)6.84965480
15synaptonemal complex assembly (GO:0007130)6.82507109
16organic cation transport (GO:0015695)6.72193064
17male meiosis (GO:0007140)6.69444238
18microtubule depolymerization (GO:0007019)6.46468737
19piRNA metabolic process (GO:0034587)6.41710366
20fertilization (GO:0009566)6.30618161
21gamete generation (GO:0007276)6.29738390
22regulation of inclusion body assembly (GO:0090083)6.06511021
23calcium ion-dependent exocytosis (GO:0017156)5.70942582
24germ cell development (GO:0007281)5.50198390
25chromosome condensation (GO:0030261)5.43392075
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.42746387
27glycerol ether metabolic process (GO:0006662)5.40087572
28spermatid nucleus differentiation (GO:0007289)5.37900399
29regulation of microtubule-based movement (GO:0060632)5.23734948
30ventricular system development (GO:0021591)5.21181295
31DNA packaging (GO:0006323)5.13674040
32cell recognition (GO:0008037)5.06116194
33ether metabolic process (GO:0018904)4.99285056
34multicellular organismal reproductive process (GO:0048609)4.95907424
35sexual reproduction (GO:0019953)4.81307620
36microtubule severing (GO:0051013)4.64813030
37male meiosis I (GO:0007141)4.64784386
38chromosome organization involved in meiosis (GO:0070192)4.61748953
39seminiferous tubule development (GO:0072520)4.57160060
40single strand break repair (GO:0000012)4.53804623
41left/right pattern formation (GO:0060972)4.30042980
42DNA methylation involved in gamete generation (GO:0043046)4.20187534
43chaperone-mediated protein complex assembly (GO:0051131)4.16111937
44sequestering of actin monomers (GO:0042989)4.12182556
45meiotic nuclear division (GO:0007126)4.04109714
46multicellular organismal development (GO:0007275)3.96634181
47genitalia morphogenesis (GO:0035112)3.78312513
48meiosis I (GO:0007127)3.69605766
49protein K11-linked deubiquitination (GO:0035871)3.60847932
50protein polyglutamylation (GO:0018095)3.46009217
51microtubule polymerization or depolymerization (GO:0031109)3.35843528
52regulation of spindle checkpoint (GO:0090231)3.30383690
53glycolytic process (GO:0006096)3.29877600
54protein refolding (GO:0042026)3.29461388
55monoubiquitinated protein deubiquitination (GO:0035520)3.22020430
56meiotic cell cycle (GO:0051321)3.16653308
57nucleus organization (GO:0006997)3.12560582
58nucleoside diphosphate phosphorylation (GO:0006165)3.08670655
59protein localization to cilium (GO:0061512)3.05565546
60amino-acid betaine transport (GO:0015838)3.04418524
61carnitine transport (GO:0015879)3.04418524
62positive regulation of macrophage activation (GO:0043032)3.02575830
63interferon-gamma secretion (GO:0072643)2.98626605
64RNA localization (GO:0006403)2.95745968
65GTP biosynthetic process (GO:0006183)2.95397936
66polyol catabolic process (GO:0046174)2.93662985
67polyamine biosynthetic process (GO:0006596)2.90607371
68carnitine transmembrane transport (GO:1902603)2.85944809
69RNA destabilization (GO:0050779)2.83903330
70alditol metabolic process (GO:0019400)2.82605133
71mitotic sister chromatid cohesion (GO:0007064)2.80807880
72chromatin silencing (GO:0006342)2.80503302
73cilium organization (GO:0044782)2.72162905
74meiotic cell cycle process (GO:1903046)2.71101416
75microtubule-based movement (GO:0007018)2.69475701
76synapsis (GO:0007129)2.68252731
77regulation of cilium assembly (GO:1902017)2.67432284
78lactate metabolic process (GO:0006089)2.66329908
79UTP biosynthetic process (GO:0006228)2.63699835
80cellular component assembly involved in morphogenesis (GO:0010927)2.61156455
81cilium assembly (GO:0042384)2.60901307
82intraciliary transport (GO:0042073)2.59372967
83cilium morphogenesis (GO:0060271)2.58588063
84negative regulation of organelle assembly (GO:1902116)2.58172506
85axoneme assembly (GO:0035082)2.56430786
86peptidyl-glutamic acid modification (GO:0018200)2.42476167
87mitochondrion degradation (GO:0000422)2.42412168
88UTP metabolic process (GO:0046051)2.41145570
89sperm motility (GO:0030317)14.4712825
90cell wall macromolecule catabolic process (GO:0016998)13.4223607
91cell wall macromolecule metabolic process (GO:0044036)13.4223607
92fusion of sperm to egg plasma membrane (GO:0007342)13.3292828
93acrosome reaction (GO:0007340)12.4859432
94sperm-egg recognition (GO:0035036)11.6085560
95acrosome assembly (GO:0001675)11.6062690
96multicellular organism reproduction (GO:0032504)10.7027109
97binding of sperm to zona pellucida (GO:0007339)10.6645424
98cell-cell recognition (GO:0009988)10.3847206
99plasma membrane fusion (GO:0045026)10.1420301
100epithelial cilium movement (GO:0003351)10.1025804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.08691351
2EZH2_22144423_ChIP-Seq_EOC_Human4.44753702
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.76768070
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13527479
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88690384
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.81833202
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.51613402
8VDR_22108803_ChIP-Seq_LS180_Human2.46409453
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20346330
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.17100616
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07363665
12ZNF274_21170338_ChIP-Seq_K562_Hela2.06213925
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99090761
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.88815121
15KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82548168
16FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75021698
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73946819
18MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.73537413
19STAT1_17558387_ChIP-Seq_HELA_Human1.70077536
20ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69524600
21SOX2_22085726_ChIP-Seq_NPCs_Mouse1.66807654
22TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66243409
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57214473
24WDR5_24793694_ChIP-Seq_LNCAP_Human1.55133098
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54860406
26GATA3_21867929_ChIP-Seq_CD8_Mouse1.54129102
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52859219
28RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48139914
29TAL1_26923725_Chip-Seq_HPCs_Mouse1.44484571
30PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43158788
31KDM2B_26808549_Chip-Seq_REH_Human1.42519943
32FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41402185
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.39469073
34CBP_20019798_ChIP-Seq_JUKART_Human1.37119969
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37119969
36REST_21632747_ChIP-Seq_MESCs_Mouse1.35415904
37P53_21459846_ChIP-Seq_SAOS-2_Human1.35163288
38KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32856637
39LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32784730
40SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31061931
41GATA3_21867929_ChIP-Seq_TH1_Mouse1.26562809
42GF1_26923725_Chip-Seq_HPCs_Mouse1.22749913
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22382728
44RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22005437
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21946504
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21599856
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21419007
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21419007
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20550025
50SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19027551
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18547251
52FLI1_21867929_ChIP-Seq_TH2_Mouse1.18495549
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.18477289
54CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18467246
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18418822
56CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16656007
57SPI1_26923725_Chip-Seq_HPCs_Mouse1.15317169
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13974564
59SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12791263
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11230060
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.09783277
62RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08333530
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08255676
64MYC_27129775_Chip-Seq_CORNEA_Mouse1.08001700
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07600132
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06924797
67ESET_19884257_ChIP-Seq_ESCs_Mouse1.06045562
68ERG_20517297_ChIP-Seq_VCAP_Human1.05866195
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05391060
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.05079506
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04850124
72GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04137874
73JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03741085
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.03666412
75RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03156744
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.02892500
77RARA_24833708_ChIP-Seq_LIVER_Mouse1.02758547
78TAF15_26573619_Chip-Seq_HEK293_Human1.02673071
79PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02184994
80CTCF_20526341_ChIP-Seq_ESCs_Human0.98908175
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98446239
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98022640
83SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97677796
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97064504
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96539869
86NFYB_21822215_ChIP-Seq_K562_Human0.96304630
87LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95363392
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94933578
89FLI1_21867929_ChIP-Seq_CD8_Mouse0.94923379
90OCT4_18555785_Chip-Seq_ESCs_Mouse0.94833525
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93922187
92P53_22387025_ChIP-Seq_ESCs_Mouse0.93172726
93CMYC_18555785_Chip-Seq_ESCs_Mouse0.91825419
94SOX9_26525672_Chip-Seq_HEART_Mouse0.91439007
95KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91097152
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.90386920
97RNF2_27304074_Chip-Seq_NSC_Mouse0.89896199
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89405986
99SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89115455
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88086118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.07010170
2MP0001929_abnormal_gametogenesis5.54179515
3MP0008877_abnormal_DNA_methylation3.79010355
4MP0002161_abnormal_fertility/fecundity3.32591695
5MP0002210_abnormal_sex_determination3.28047135
6MP0005670_abnormal_white_adipose2.86779570
7MP0001145_abnormal_male_reproductive2.82299890
8MP0000653_abnormal_sex_gland2.43125417
9MP0002653_abnormal_ependyma_morphology2.10876812
10MP0005410_abnormal_fertilization16.7191518
11MP0002160_abnormal_reproductive_system1.57507138
12MP0004233_abnormal_muscle_weight1.54771752
13MP0003646_muscle_fatigue1.50600309
14MP0005623_abnormal_meninges_morphology1.42870150
15MP0002282_abnormal_trachea_morphology1.24631386
16MP0001765_abnormal_ion_homeostasis1.11932139
17MP0001984_abnormal_olfaction1.08418209
18MP0005647_abnormal_sex_gland0.90587751
19MP0008995_early_reproductive_senescence0.84380250
20MP0005389_reproductive_system_phenotype0.77204312
21MP0002234_abnormal_pharynx_morphology0.77190132
22MP0008058_abnormal_DNA_repair0.72542157
23MP0003115_abnormal_respiratory_system0.71043268
24MP0009046_muscle_twitch0.68974299
25MP0005636_abnormal_mineral_homeostasis0.62056980
26MP0009278_abnormal_bone_marrow0.61884859
27MP0003011_delayed_dark_adaptation0.59289494
28MP0001324_abnormal_eye_pigmentation0.57400179
29MP0003329_amyloid_beta_deposits0.56758262
30MP0003878_abnormal_ear_physiology0.56264783
31MP0005377_hearing/vestibular/ear_phenot0.56264783
32MP0005666_abnormal_adipose_tissue0.54369457
33MP0004036_abnormal_muscle_relaxation0.50658813
34MP0005253_abnormal_eye_physiology0.50538320
35MP0001545_abnormal_hematopoietic_system0.49392069
36MP0005397_hematopoietic_system_phenotyp0.49392069
37MP0003699_abnormal_female_reproductive0.49070800
38MP0000358_abnormal_cell_content/0.48246574
39MP0002269_muscular_atrophy0.46557932
40MP0001293_anophthalmia0.44583862
41MP0001764_abnormal_homeostasis0.43370906
42MP0001348_abnormal_lacrimal_gland0.40922134
43MP0005551_abnormal_eye_electrophysiolog0.40552114
44MP0010094_abnormal_chromosome_stability0.40101844
45MP0006036_abnormal_mitochondrial_physio0.39667985
46MP0002736_abnormal_nociception_after0.39183933
47MP0005391_vision/eye_phenotype0.36132553
48MP0004133_heterotaxia0.35750994
49MP0009115_abnormal_fat_cell0.35366677
50MP0000534_abnormal_ureter_morphology0.34984483
51MP0006035_abnormal_mitochondrial_morpho0.34604055
52MP0002928_abnormal_bile_duct0.33975735
53MP0008057_abnormal_DNA_replication0.31972033
54MP0003950_abnormal_plasma_membrane0.31849955
55MP0001727_abnormal_embryo_implantation0.31066835
56MP0004811_abnormal_neuron_physiology0.29573619
57MP0003633_abnormal_nervous_system0.29570611
58MP0002971_abnormal_brown_adipose0.29183405
59MP0003942_abnormal_urinary_system0.28332233
60MP0000604_amyloidosis0.27768812
61MP0000462_abnormal_digestive_system0.26988297
62MP0004742_abnormal_vestibular_system0.26421481
63MP0000569_abnormal_digit_pigmentation0.25388968
64MP0003861_abnormal_nervous_system0.24970386
65MP0004019_abnormal_vitamin_homeostasis0.24366001
66MP0003631_nervous_system_phenotype0.24150187
67MP0000920_abnormal_myelination0.23921560
68MP0002169_no_abnormal_phenotype0.23913105
69MP0002873_normal_phenotype0.23760430
70MP0002152_abnormal_brain_morphology0.23637804
71MP0004145_abnormal_muscle_electrophysio0.23156305
72MP0001119_abnormal_female_reproductive0.21640818
73MP0002139_abnormal_hepatobiliary_system0.21279530
74MP0001730_embryonic_growth_arrest0.21249625
75MP0002822_catalepsy0.21076464
76MP0001968_abnormal_touch/_nociception0.20553868
77MP0000751_myopathy0.20058125
78MP0003111_abnormal_nucleus_morphology0.19838950
79MP0003786_premature_aging0.19698163
80MP0003948_abnormal_gas_homeostasis0.19614362
81MP0002295_abnormal_pulmonary_circulatio0.19177400
82MP0002092_abnormal_eye_morphology0.18494222
83MP0004270_analgesia0.18348577
84MP0005195_abnormal_posterior_eye0.16711727
85MP0003879_abnormal_hair_cell0.15962439
86MP0001849_ear_inflammation0.15923566
87MP0006072_abnormal_retinal_apoptosis0.15681267
88MP0000313_abnormal_cell_death0.15504545
89MP0004043_abnormal_pH_regulation0.15470605
90MP0008569_lethality_at_weaning0.15071516
91MP0002229_neurodegeneration0.14954956
92MP0000001_mammalian_phenotype0.14829606
93MP0002084_abnormal_developmental_patter0.14794073
94MP0002108_abnormal_muscle_morphology0.14744087
95MP0005319_abnormal_enzyme/_coenzyme0.14694206
96MP0005375_adipose_tissue_phenotype0.14266831
97MP0003634_abnormal_glial_cell0.14148649
98MP0002102_abnormal_ear_morphology0.14034507
99MP0002909_abnormal_adrenal_gland0.13781733
100MP0002118_abnormal_lipid_homeostasis0.12702553

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.41815032
2Abnormal respiratory motile cilium morphology (HP:0005938)9.41815032
3Abnormal respiratory motile cilium physiology (HP:0012261)9.36105845
4Rhinitis (HP:0012384)7.44706307
5Chronic bronchitis (HP:0004469)7.40936982
6Abnormal ciliary motility (HP:0012262)7.38703503
7Infertility (HP:0000789)7.08516211
8Nasal polyposis (HP:0100582)6.31855815
9Abnormality of the nasal mucosa (HP:0000433)5.18911647
10Male infertility (HP:0003251)5.05461638
11Bronchitis (HP:0012387)4.55294078
12Bronchiectasis (HP:0002110)4.35578043
13Nephronophthisis (HP:0000090)4.03705736
14Abnormal spermatogenesis (HP:0008669)3.58037193
15Recurrent sinusitis (HP:0011108)3.38438129
16Recurrent otitis media (HP:0000403)3.27546705
17Abnormality of the renal medulla (HP:0100957)3.01393306
18Tubulointerstitial nephritis (HP:0001970)2.95607599
19Recurrent bronchitis (HP:0002837)2.64865475
20Impulsivity (HP:0100710)2.55520598
21Tubular atrophy (HP:0000092)2.55042740
22Abnormality of midbrain morphology (HP:0002418)2.45917294
23Molar tooth sign on MRI (HP:0002419)2.45917294
24Tubulointerstitial abnormality (HP:0001969)2.44218813
25Cholecystitis (HP:0001082)2.41211320
26Abnormal gallbladder physiology (HP:0012438)2.41211320
27Medial flaring of the eyebrow (HP:0010747)2.38215453
28Dyschromatopsia (HP:0007641)2.29031463
29Gonadotropin excess (HP:0000837)2.23904824
30Hemorrhage of the eye (HP:0011885)2.22452662
31Azoospermia (HP:0000027)2.17361171
32Decreased central vision (HP:0007663)2.00527095
33Dynein arm defect of respiratory motile cilia (HP:0012255)13.5810922
34Absent/shortened dynein arms (HP:0200106)13.5810922
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0783992
36Choroideremia (HP:0001139)1.99510561
37Spastic tetraparesis (HP:0001285)1.91421585
38Tubulointerstitial fibrosis (HP:0005576)1.90427982
39Polydipsia (HP:0001959)1.84776917
40Abnormal drinking behavior (HP:0030082)1.84776917
41Double outlet right ventricle (HP:0001719)1.80190387
42Congenital malformation of the right heart (HP:0011723)1.80190387
43Postaxial foot polydactyly (HP:0001830)1.75153809
44Stage 5 chronic kidney disease (HP:0003774)1.72144994
45Abnormality of renal excretion (HP:0011036)1.72004166
46Heterotopia (HP:0002282)1.69663856
47Neurofibrillary tangles (HP:0002185)1.69391486
48Asymmetric septal hypertrophy (HP:0001670)1.67766065
49Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60499992
50Abnormal biliary tract physiology (HP:0012439)1.58137943
51Bile duct proliferation (HP:0001408)1.58137943
52Abnormality of permanent molar morphology (HP:0011071)1.56778753
53Abnormality of the dental root (HP:0006486)1.56778753
54Taurodontia (HP:0000679)1.56778753
55Abnormality of the renal cortex (HP:0011035)1.53383305
56Congenital hepatic fibrosis (HP:0002612)1.52148358
57Decreased electroretinogram (ERG) amplitude (HP:0000654)1.47514963
58Abnormality of dentin (HP:0010299)1.47196985
59Bell-shaped thorax (HP:0001591)1.46393807
60Abnormality of the dental pulp (HP:0006479)1.45428334
61Abnormality of molar (HP:0011077)1.44553708
62Abnormality of molar morphology (HP:0011070)1.44553708
63Aplasia/Hypoplasia of the lens (HP:0008063)1.44487268
64Short ribs (HP:0000773)1.44280218
65Oculomotor apraxia (HP:0000657)1.43082455
66Abnormal urine output (HP:0012590)1.42860287
67Broad distal phalanx of finger (HP:0009836)1.40847251
68Bundle branch block (HP:0011710)1.40751221
69Postaxial hand polydactyly (HP:0001162)1.36897284
70Cerebral inclusion bodies (HP:0100314)1.36560720
71Fibular hypoplasia (HP:0003038)1.34913324
72Exercise-induced myalgia (HP:0003738)1.32859656
73Sensory axonal neuropathy (HP:0003390)1.29442653
74Cystic liver disease (HP:0006706)1.28601828
75Abnormality of the neuromuscular junction (HP:0003398)1.27589676
76Fatigable weakness (HP:0003473)1.27589676
77Renal dysplasia (HP:0000110)1.26913303
78Easy fatigability (HP:0003388)1.26276904
79Absent epiphyses (HP:0010577)1.25562574
80Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.25562574
81Deformed sella turcica (HP:0002681)1.24631902
82Gait imbalance (HP:0002141)1.24036753
83Congenital primary aphakia (HP:0007707)1.23439704
84Myoglobinuria (HP:0002913)1.23371974
85Abnormality of the lower motor neuron (HP:0002366)1.22631348
86Constricted visual fields (HP:0001133)1.22070322
87Chronic sinusitis (HP:0011109)1.20932167
88Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.20066728
89Polyuria (HP:0000103)1.17386694
90Hypercholesterolemia (HP:0003124)1.17291169
91Loss of speech (HP:0002371)1.16913026
92Hemiparesis (HP:0001269)1.15416377
93Vascular calcification (HP:0004934)1.14466663
94Rhabdomyolysis (HP:0003201)1.12144138
95Short femoral neck (HP:0100864)1.12116840
96Absent frontal sinuses (HP:0002688)1.11236425
97Facial cleft (HP:0002006)1.10711042
98Nephropathy (HP:0000112)1.10098673
99J-shaped sella turcica (HP:0002680)1.08707525
100Generalized muscle weakness (HP:0003324)1.06975731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.11913667
2PDK48.11913667
3TESK16.42035391
4PDK25.24524314
5PRKD34.88913236
6ICK4.85333946
7PTK2B2.22114565
8STK392.09573539
9WNK42.04987385
10STK381.81132529
11PNCK1.74417487
12DYRK1B1.70800950
13NEK21.50866584
14MAPK151.27358871
15PDK11.21314751
16TYRO31.17540046
17DYRK30.90943692
18IRAK10.85210210
19PDPK10.77269853
20WNK10.74642587
21PINK10.72544359
22TESK20.65705024
23RIPK40.64717738
24PASK0.60137402
25MAP2K60.58948078
26CHEK20.57947277
27IRAK20.57595755
28TTK0.56990861
29STK30.55998286
30EEF2K0.55166963
31CCNB10.52021763
32CAMK1G0.43919618
33PAK10.43506117
34LMTK20.42757949
35MUSK0.39166619
36NTRK20.37417415
37PRKCG0.35892691
38CHEK10.35874810
39STK38L0.34848322
40PAK20.34552415
41MAP3K100.33944269
42MARK20.26693963
43ATM0.25552631
44MTOR0.24006504
45PAK40.23759672
46TNIK0.21813591
47PRKAA10.21382737
48PRKCZ0.19273177
49MAPKAPK50.18394915
50CAMKK10.17772958
51ATR0.17244384
52CDK150.16550651
53RPS6KB10.16414082
54CLK10.14313736
55RPS6KA10.13920428
56CDK180.13694153
57NEK60.13217520
58CDK11A0.13109089
59YES10.12679292
60PRKCQ0.12669389
61CSK0.12629399
62EPHB10.12511468
63PLK10.10856771
64CDK60.10205848
65CAMK2A0.10183273
66PRKG20.09083254
67PLK40.08780459
68CSNK2A10.08390992
69CDK140.08168998
70PIM10.08154133
71GSK3B0.07850721
72WEE10.07806222
73PKN10.06967927
74CSNK1D0.06927474
75CSF1R0.06503377
76PRKACG0.05710790
77EGFR0.05286067
78DDR20.04872166
79PRKCD0.04819839
80PRKG10.03941984
81CSNK2A20.03175341
82CDK20.02880400
83MAPK80.02641695
84BRSK20.02021062
85CDK10.01985223
86PRKCA0.00783939
87GSK3A0.00742610
88PRKCB0.00539423
89MAP3K5-0.0288891
90SRC-0.0265195
91AURKA-0.0210681
92RPS6KA3-0.0173272
93PRKACB-0.0165400
94PRKACA-0.0164745
95PDGFRB-0.0140610
96MARK3-0.0119589
97BRSK1-0.0111314
98BRAF-0.0102307
99CDC7-0.0068563
100UHMK1-0.0057904

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.05722873
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.53121295
3Vitamin B6 metabolism_Homo sapiens_hsa007503.58936753
4Pyruvate metabolism_Homo sapiens_hsa006203.47281545
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.14612240
6Linoleic acid metabolism_Homo sapiens_hsa005913.06471822
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.85193489
8Propanoate metabolism_Homo sapiens_hsa006402.56225405
9Glucagon signaling pathway_Homo sapiens_hsa049222.52349944
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.46007286
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.29972056
12Basal transcription factors_Homo sapiens_hsa030222.01888427
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.00626847
14Glycerolipid metabolism_Homo sapiens_hsa005611.89356116
15Selenocompound metabolism_Homo sapiens_hsa004501.85888834
16PPAR signaling pathway_Homo sapiens_hsa033201.84650024
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.79641189
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.65697847
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.65044010
20Mineral absorption_Homo sapiens_hsa049781.63890264
21Ether lipid metabolism_Homo sapiens_hsa005651.61900947
22Fructose and mannose metabolism_Homo sapiens_hsa000511.60598629
23Oocyte meiosis_Homo sapiens_hsa041141.58918881
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.56230740
25Fatty acid metabolism_Homo sapiens_hsa012121.53548325
26Amphetamine addiction_Homo sapiens_hsa050311.48518925
27Fat digestion and absorption_Homo sapiens_hsa049751.48510244
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45597317
29Pentose phosphate pathway_Homo sapiens_hsa000301.44949356
30Cardiac muscle contraction_Homo sapiens_hsa042601.39865949
31Fatty acid degradation_Homo sapiens_hsa000711.35525076
32Carbon metabolism_Homo sapiens_hsa012001.29973092
33Dorso-ventral axis formation_Homo sapiens_hsa043201.27200981
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25861125
35Glutathione metabolism_Homo sapiens_hsa004801.19554238
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.13810487
37Collecting duct acid secretion_Homo sapiens_hsa049661.06675194
38Fanconi anemia pathway_Homo sapiens_hsa034601.04869071
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04256246
40Renin secretion_Homo sapiens_hsa049241.03973815
41Antigen processing and presentation_Homo sapiens_hsa046121.00505575
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96873849
43Hedgehog signaling pathway_Homo sapiens_hsa043400.96068872
44Huntingtons disease_Homo sapiens_hsa050160.92994311
45mRNA surveillance pathway_Homo sapiens_hsa030150.91979800
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.91325888
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90272143
48Biosynthesis of amino acids_Homo sapiens_hsa012300.89314595
49Purine metabolism_Homo sapiens_hsa002300.87887679
50Arachidonic acid metabolism_Homo sapiens_hsa005900.86856656
51Insulin secretion_Homo sapiens_hsa049110.75479153
52Chemical carcinogenesis_Homo sapiens_hsa052040.75314248
53Bile secretion_Homo sapiens_hsa049760.71786717
54Thyroid hormone synthesis_Homo sapiens_hsa049180.71657909
55Estrogen signaling pathway_Homo sapiens_hsa049150.71515824
56Long-term potentiation_Homo sapiens_hsa047200.70326360
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65453883
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.64143972
59RNA transport_Homo sapiens_hsa030130.60868517
60Legionellosis_Homo sapiens_hsa051340.56731434
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54641642
62Systemic lupus erythematosus_Homo sapiens_hsa053220.53509096
63Pancreatic secretion_Homo sapiens_hsa049720.53345629
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52431002
65Synaptic vesicle cycle_Homo sapiens_hsa047210.49604935
66VEGF signaling pathway_Homo sapiens_hsa043700.48945446
67Salivary secretion_Homo sapiens_hsa049700.48539245
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46106925
69Protein digestion and absorption_Homo sapiens_hsa049740.45972326
70Calcium signaling pathway_Homo sapiens_hsa040200.45180400
71Endocytosis_Homo sapiens_hsa041440.43340805
72AMPK signaling pathway_Homo sapiens_hsa041520.41500235
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38872907
74Renin-angiotensin system_Homo sapiens_hsa046140.38750878
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38493139
76ABC transporters_Homo sapiens_hsa020100.38402577
77Sulfur metabolism_Homo sapiens_hsa009200.38216275
78Gastric acid secretion_Homo sapiens_hsa049710.37464166
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.36539042
80Metabolic pathways_Homo sapiens_hsa011000.36494814
81Inositol phosphate metabolism_Homo sapiens_hsa005620.35557816
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33623545
83B cell receptor signaling pathway_Homo sapiens_hsa046620.31991352
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30982287
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30780431
86cAMP signaling pathway_Homo sapiens_hsa040240.30052047
87Alcoholism_Homo sapiens_hsa050340.26972333
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26775581
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26288178
90Circadian entrainment_Homo sapiens_hsa047130.20896970
91Taste transduction_Homo sapiens_hsa047420.20251619
92Pyrimidine metabolism_Homo sapiens_hsa002400.17309176
93Wnt signaling pathway_Homo sapiens_hsa043100.14521257
94Basal cell carcinoma_Homo sapiens_hsa052170.12294580
95Cocaine addiction_Homo sapiens_hsa050300.11537639
96HIF-1 signaling pathway_Homo sapiens_hsa040660.07580032
97Toxoplasmosis_Homo sapiens_hsa051450.07349237
98Glutamatergic synapse_Homo sapiens_hsa047240.06472747
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.05365622
100Salmonella infection_Homo sapiens_hsa051320.05223104

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