SMIM20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.92487021
2ATP synthesis coupled proton transport (GO:0015986)6.59418309
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.59418309
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.03558135
5respiratory electron transport chain (GO:0022904)5.66627597
6electron transport chain (GO:0022900)5.54913447
7protein complex biogenesis (GO:0070271)5.14396798
8mitochondrial respiratory chain complex I assembly (GO:0032981)5.08374180
9NADH dehydrogenase complex assembly (GO:0010257)5.08374180
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.08374180
11ribosomal small subunit assembly (GO:0000028)4.81299420
12chaperone-mediated protein transport (GO:0072321)4.74574799
13oxidative phosphorylation (GO:0006119)4.70112271
14mitochondrial respiratory chain complex assembly (GO:0033108)4.68042045
15DNA deamination (GO:0045006)4.61681026
16respiratory chain complex IV assembly (GO:0008535)4.29475614
17proteasome assembly (GO:0043248)4.18423757
18metallo-sulfur cluster assembly (GO:0031163)4.13646468
19iron-sulfur cluster assembly (GO:0016226)4.13646468
20signal peptide processing (GO:0006465)4.02568253
21ribosomal large subunit biogenesis (GO:0042273)3.95436610
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.92676211
23protein neddylation (GO:0045116)3.87990258
24mannosylation (GO:0097502)3.81534681
25maturation of SSU-rRNA (GO:0030490)3.80533137
26daunorubicin metabolic process (GO:0044597)3.79674473
27polyketide metabolic process (GO:0030638)3.79674473
28doxorubicin metabolic process (GO:0044598)3.79674473
29water-soluble vitamin biosynthetic process (GO:0042364)3.77565260
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.76464572
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.76464572
32aerobic respiration (GO:0009060)3.74525894
33cytochrome complex assembly (GO:0017004)3.72116140
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.68194968
35peptidyl-histidine modification (GO:0018202)3.66669951
36heart contraction (GO:0060047)3.64894015
37heart process (GO:0003015)3.64894015
38ubiquinone biosynthetic process (GO:0006744)3.63668274
39quinone biosynthetic process (GO:1901663)3.63668274
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.58961048
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.58809362
42cotranslational protein targeting to membrane (GO:0006613)3.55762147
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52514641
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51941416
45protein targeting to ER (GO:0045047)3.51129452
46protein targeting to mitochondrion (GO:0006626)3.50392019
47ATP biosynthetic process (GO:0006754)3.50116066
48regulation of mitochondrial translation (GO:0070129)3.49912944
49termination of RNA polymerase III transcription (GO:0006386)3.48721563
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.48721563
51chromatin remodeling at centromere (GO:0031055)3.47354912
52regulation of cellular amino acid metabolic process (GO:0006521)3.46478627
53protein localization to endoplasmic reticulum (GO:0070972)3.44234488
54ubiquinone metabolic process (GO:0006743)3.38993419
55CENP-A containing nucleosome assembly (GO:0034080)3.38104899
56establishment of integrated proviral latency (GO:0075713)3.34858983
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.34271351
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33421598
59antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.32670869
60GPI anchor biosynthetic process (GO:0006506)3.32099889
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28246458
62negative regulation of ligase activity (GO:0051352)3.28246458
63establishment of protein localization to mitochondrion (GO:0072655)3.27823379
64DNA damage response, detection of DNA damage (GO:0042769)3.27639629
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27491905
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27491905
67viral transcription (GO:0019083)3.25887491
68purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.24863819
69purine nucleoside triphosphate biosynthetic process (GO:0009145)3.24309465
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23945664
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23945664
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23945664
73ribosomal small subunit biogenesis (GO:0042274)3.22729930
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.22698578
75purine nucleobase biosynthetic process (GO:0009113)3.22206975
76translational termination (GO:0006415)3.17620660
77spliceosomal snRNP assembly (GO:0000387)3.16167369
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10737418
79L-methionine salvage (GO:0071267)3.08141092
80L-methionine biosynthetic process (GO:0071265)3.08141092
81amino acid salvage (GO:0043102)3.08141092
82pseudouridine synthesis (GO:0001522)3.06350683
83signal transduction involved in DNA damage checkpoint (GO:0072422)3.06111317
84signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06111317
85hydrogen ion transmembrane transport (GO:1902600)3.05859242
86GTP biosynthetic process (GO:0006183)3.04306042
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04099240
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02961513
89signal transduction involved in cell cycle checkpoint (GO:0072395)3.02611890
90protein deneddylation (GO:0000338)3.02097306
91translation (GO:0006412)3.01352779
92translational initiation (GO:0006413)3.01112325
93cellular component biogenesis (GO:0044085)3.00013848
94mitochondrial transport (GO:0006839)2.99891633
95inner mitochondrial membrane organization (GO:0007007)2.97082119
96cullin deneddylation (GO:0010388)2.95200986
97protein localization to mitochondrion (GO:0070585)2.94655060
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.94558138
99quinone metabolic process (GO:1901661)2.92139077
100positive regulation of ligase activity (GO:0051351)2.91750407
101histone mRNA metabolic process (GO:0008334)2.90426859
102aldehyde catabolic process (GO:0046185)2.90065825
103fatty acid elongation (GO:0030497)2.89608643
104L-serine metabolic process (GO:0006563)2.89141855
105regulation of helicase activity (GO:0051095)2.88018762
106intracellular protein transmembrane import (GO:0044743)2.87711461
107base-excision repair, AP site formation (GO:0006285)2.86425302
108establishment of protein localization to mitochondrial membrane (GO:0090151)2.84937482
109histone exchange (GO:0043486)2.84003639
110regulation of cellular respiration (GO:0043457)2.82669809
111proton transport (GO:0015992)2.81336173
112protein-cofactor linkage (GO:0018065)2.81196865
113antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.80625041
114translational elongation (GO:0006414)2.79792779
115GDP-mannose metabolic process (GO:0019673)2.79195085
116GPI anchor metabolic process (GO:0006505)2.79142405
117establishment of viral latency (GO:0019043)2.78306247
118anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78300181
119maturation of 5.8S rRNA (GO:0000460)2.77259855
120viral life cycle (GO:0019058)2.77073902
121cellular respiration (GO:0045333)2.76067131
122regulation of cellular amine metabolic process (GO:0033238)2.75208064
123hydrogen transport (GO:0006818)2.75071580
124platelet dense granule organization (GO:0060155)2.72630379
125rRNA modification (GO:0000154)2.72628676
126regulation of oxidative phosphorylation (GO:0002082)2.72471877
1277-methylguanosine mRNA capping (GO:0006370)2.71832668
128protein maturation by protein folding (GO:0022417)2.69672280
129nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69502035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.79731963
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.43290812
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.13581078
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02280489
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.91942276
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.84396786
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.47700157
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.24099185
9SRF_21415370_ChIP-Seq_HL-1_Mouse3.18640236
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.17461229
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.08191270
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.07510927
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.03286114
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98098666
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.97652630
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.76201876
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.65006811
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61098128
19VDR_23849224_ChIP-Seq_CD4+_Human2.54794186
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46119884
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34252317
22FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.33752983
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.30772366
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28815813
25HOXB4_20404135_ChIP-ChIP_EML_Mouse2.25570162
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24299192
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15474568
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12770987
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11129195
30FOXP3_21729870_ChIP-Seq_TREG_Human2.10404206
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.10165131
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09960956
33ERG_20887958_ChIP-Seq_HPC-7_Mouse2.06900289
34ZNF274_21170338_ChIP-Seq_K562_Hela2.04529293
35DCP1A_22483619_ChIP-Seq_HELA_Human2.03941284
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.98719788
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.94315996
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91865348
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87168150
40GABP_19822575_ChIP-Seq_HepG2_Human1.84785134
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77381998
42ELK1_19687146_ChIP-ChIP_HELA_Human1.73558377
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67611412
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66263441
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65595515
46EWS_26573619_Chip-Seq_HEK293_Human1.65468029
47XRN2_22483619_ChIP-Seq_HELA_Human1.65360952
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63615657
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.63242649
50GATA1_22025678_ChIP-Seq_K562_Human1.60009972
51FUS_26573619_Chip-Seq_HEK293_Human1.57293959
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54681015
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50175416
54IGF1R_20145208_ChIP-Seq_DFB_Human1.49297482
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47890556
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45574167
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45467518
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45002311
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43548811
60E2F7_22180533_ChIP-Seq_HELA_Human1.42540133
61IRF1_19129219_ChIP-ChIP_H3396_Human1.37091839
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34423930
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33352849
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33155824
65TTF2_22483619_ChIP-Seq_HELA_Human1.31156426
66SPI1_23547873_ChIP-Seq_NB4_Human1.29777485
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.29076512
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27993411
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.27427534
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26231546
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25397427
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.23994667
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22939374
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19940064
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15996982
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13761020
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.13715581
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12180021
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10086576
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10063268
81CIITA_25753668_ChIP-Seq_RAJI_Human1.09999200
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08826550
83P300_19829295_ChIP-Seq_ESCs_Human1.07349939
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07222212
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06673444
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06415366
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05167628
88IRF8_21731497_ChIP-ChIP_J774_Mouse1.04453373
89SCL_19346495_ChIP-Seq_HPC-7_Human1.03491356
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03041256
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02416816
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.01980140
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01468940
94MYC_18940864_ChIP-ChIP_HL60_Human1.00603886
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00032534
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99707970
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99195813
98HTT_18923047_ChIP-ChIP_STHdh_Human0.95593262
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95315113
100NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94948458
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94786831
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94494605
103AR_20517297_ChIP-Seq_VCAP_Human0.94487189
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93512707
105CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92869403
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91976486
107TP53_22573176_ChIP-Seq_HFKS_Human0.91764273
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90911430
109VDR_22108803_ChIP-Seq_LS180_Human0.90574716
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90311556
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90286078
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89686065
113AR_21909140_ChIP-Seq_LNCAP_Human0.89547005
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89362629
115NANOG_19829295_ChIP-Seq_ESCs_Human0.89139092
116SOX2_19829295_ChIP-Seq_ESCs_Human0.89139092
117E2F1_21310950_ChIP-Seq_MCF-7_Human0.88942672
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88517311
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87312321
120NOTCH1_21737748_ChIP-Seq_TLL_Human0.86905516
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.86062850
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86062850
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85984461
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84607660
125MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84408311
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83952480
127RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83869779
128CTCF_26484167_Chip-Seq_Bcells_Mouse0.83035016
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82703058
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82679035
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81409807
132ERG_20517297_ChIP-Seq_VCAP_Human0.80442981
133NANOG_20526341_ChIP-Seq_ESCs_Human0.79824263
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79745627
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79366913
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.77964377
137SOX17_20123909_ChIP-Seq_XEN_Mouse0.77196814
138NFE2_27457419_Chip-Seq_LIVER_Mouse0.76670794
139TAF15_26573619_Chip-Seq_HEK293_Human0.76552847
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75974795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.89162144
2MP0006036_abnormal_mitochondrial_physio3.51257926
3MP0006292_abnormal_olfactory_placode3.27707392
4MP0004147_increased_porphyrin_level2.95247719
5MP0000749_muscle_degeneration2.87425270
6MP0003646_muscle_fatigue2.84931916
7MP0003186_abnormal_redox_activity2.78483368
8MP0001529_abnormal_vocalization2.56565669
9MP0009379_abnormal_foot_pigmentation2.34191375
10MP0002837_dystrophic_cardiac_calcinosis2.32171228
11MP0004036_abnormal_muscle_relaxation2.31777937
12MP0003718_maternal_effect2.30220850
13MP0008789_abnormal_olfactory_epithelium2.25274799
14MP0004084_abnormal_cardiac_muscle2.23328814
15MP0001835_abnormal_antigen_presentation2.21374678
16MP0009785_altered_susceptibility_to2.16050222
17MP0001905_abnormal_dopamine_level2.12242232
18MP0006035_abnormal_mitochondrial_morpho2.11479337
19MP0006072_abnormal_retinal_apoptosis2.10294107
20MP0002102_abnormal_ear_morphology2.07798191
21MP0008877_abnormal_DNA_methylation2.06856623
22MP0001986_abnormal_taste_sensitivity2.00380289
23MP0009697_abnormal_copulation1.96395598
24MP0005671_abnormal_response_to1.89288761
25MP0002638_abnormal_pupillary_reflex1.84787684
26MP0004043_abnormal_pH_regulation1.81292344
27MP0002148_abnormal_hypersensitivity_rea1.77949063
28MP0001764_abnormal_homeostasis1.77227413
29MP0001293_anophthalmia1.76488937
30MP0010094_abnormal_chromosome_stability1.76019317
31MP0005330_cardiomyopathy1.75680926
32MP0001984_abnormal_olfaction1.72705032
33MP0003724_increased_susceptibility_to1.72102694
34MP0004215_abnormal_myocardial_fiber1.70726581
35MP0000372_irregular_coat_pigmentation1.67594635
36MP0000920_abnormal_myelination1.62883701
37MP0002090_abnormal_vision1.61013478
38MP0003011_delayed_dark_adaptation1.57959879
39MP0003567_abnormal_fetal_cardiomyocyte1.52610573
40MP0008932_abnormal_embryonic_tissue1.51770965
41MP0002736_abnormal_nociception_after1.50833344
42MP0003656_abnormal_erythrocyte_physiolo1.49605515
43MP0010030_abnormal_orbit_morphology1.48834176
44MP0005025_abnormal_response_to1.48099387
45MP0004142_abnormal_muscle_tone1.42900491
46MP0005058_abnormal_lysosome_morphology1.42316723
47MP0000685_abnormal_immune_system1.37525706
48MP0005379_endocrine/exocrine_gland_phen1.37361731
49MP0003786_premature_aging1.35904324
50MP0002132_abnormal_respiratory_system1.35540789
51MP0009333_abnormal_splenocyte_physiolog1.34649469
52MP0003195_calcinosis1.34092277
53MP0005551_abnormal_eye_electrophysiolog1.33774678
54MP0005075_abnormal_melanosome_morpholog1.33013792
55MP0008872_abnormal_physiological_respon1.31496482
56MP0001485_abnormal_pinna_reflex1.30348746
57MP0002163_abnormal_gland_morphology1.29786070
58MP0000751_myopathy1.29200813
59MP0005451_abnormal_body_composition1.28765192
60MP0003950_abnormal_plasma_membrane1.26969154
61MP0005253_abnormal_eye_physiology1.26838143
62MP0002876_abnormal_thyroid_physiology1.26759478
63MP0005000_abnormal_immune_tolerance1.26739509
64MP0005266_abnormal_metabolism1.26375956
65MP0005387_immune_system_phenotype1.25185932
66MP0001790_abnormal_immune_system1.25185932
67MP0005394_taste/olfaction_phenotype1.24719695
68MP0005499_abnormal_olfactory_system1.24719695
69MP0002653_abnormal_ependyma_morphology1.23990592
70MP0002972_abnormal_cardiac_muscle1.18393835
71MP0005636_abnormal_mineral_homeostasis1.16531410
72MP0004145_abnormal_muscle_electrophysio1.15878570
73MP0000049_abnormal_middle_ear1.15360153
74MP0003693_abnormal_embryo_hatching1.15291383
75MP0003763_abnormal_thymus_physiology1.15060571
76MP0003221_abnormal_cardiomyocyte_apopto1.14785650
77MP0002420_abnormal_adaptive_immunity1.13796180
78MP0001968_abnormal_touch/_nociception1.12952539
79MP0002723_abnormal_immune_serum1.12277005
80MP0001819_abnormal_immune_cell1.11846846
81MP0005646_abnormal_pituitary_gland1.11807702
82MP0000516_abnormal_urinary_system1.11601833
83MP0005367_renal/urinary_system_phenotyp1.11601833
84MP0005584_abnormal_enzyme/coenzyme_acti1.11116786
85MP0003077_abnormal_cell_cycle1.10808851
86MP0003111_abnormal_nucleus_morphology1.10160789
87MP0002419_abnormal_innate_immunity1.05759781
88MP0005332_abnormal_amino_acid1.05208240
89MP0002106_abnormal_muscle_physiology1.04675886
90MP0001800_abnormal_humoral_immune1.04599192
91MP0000747_muscle_weakness1.04319704
92MP0002396_abnormal_hematopoietic_system1.04258027
93MP0002233_abnormal_nose_morphology1.03272774
94MP0008007_abnormal_cellular_replicative1.03168410
95MP0003941_abnormal_skin_development1.02996727
96MP0000358_abnormal_cell_content/1.02342781
97MP0000631_abnormal_neuroendocrine_gland1.02058191
98MP0008058_abnormal_DNA_repair1.01496660
99MP0001853_heart_inflammation0.99141209
100MP0008469_abnormal_protein_level0.98420523
101MP0002452_abnormal_antigen_presenting0.97315967
102MP0005376_homeostasis/metabolism_phenot0.95461665
103MP0006082_CNS_inflammation0.94878453
104MP0004133_heterotaxia0.93818044
105MP0005385_cardiovascular_system_phenoty0.93451426
106MP0001544_abnormal_cardiovascular_syste0.93451426
107MP0003937_abnormal_limbs/digits/tail_de0.91990921
108MP0001929_abnormal_gametogenesis0.90855150
109MP0000716_abnormal_immune_system0.90551508
110MP0003137_abnormal_impulse_conducting0.90407167
111MP0005084_abnormal_gallbladder_morpholo0.90208735
112MP0002210_abnormal_sex_determination0.89765525
113MP0006054_spinal_hemorrhage0.89604823
114MP0002160_abnormal_reproductive_system0.88847063
115MP0002398_abnormal_bone_marrow0.88670343
116MP0000343_altered_response_to0.88381890
117MP0008995_early_reproductive_senescence0.88042830
118MP0000647_abnormal_sebaceous_gland0.87695468
119MP0002429_abnormal_blood_cell0.86352216
120MP0005620_abnormal_muscle_contractility0.86236277
121MP0001286_abnormal_eye_development0.86106979
122MP0000653_abnormal_sex_gland0.85584493
123MP0002234_abnormal_pharynx_morphology0.85379797
124MP0008775_abnormal_heart_ventricle0.84832222
125MP0009643_abnormal_urine_homeostasis0.84633666
126MP0002938_white_spotting0.84421234
127MP0006276_abnormal_autonomic_nervous0.84292026
128MP0003121_genomic_imprinting0.84137730
129MP0009840_abnormal_foam_cell0.83404089
130MP0000689_abnormal_spleen_morphology0.82812795
131MP0004019_abnormal_vitamin_homeostasis0.81377462
132MP0001145_abnormal_male_reproductive0.80734759
133MP0005645_abnormal_hypothalamus_physiol0.79397433
134MP0002277_abnormal_respiratory_mucosa0.79208271
135MP0002693_abnormal_pancreas_physiology0.78941708
136MP0003878_abnormal_ear_physiology0.77946521
137MP0005377_hearing/vestibular/ear_phenot0.77946521
138MP0003787_abnormal_imprinting0.77766310
139MP0005410_abnormal_fertilization0.77643645
140MP0003866_abnormal_defecation0.77436781
141MP0005408_hypopigmentation0.77180122
142MP0003136_yellow_coat_color0.76899404
143MP0002269_muscular_atrophy0.76866942
144MP0002138_abnormal_hepatobiliary_system0.76692907
145MP0004957_abnormal_blastocyst_morpholog0.76350541
146MP0002722_abnormal_immune_system0.75594187
147MP0005310_abnormal_salivary_gland0.74956093
148MP0003436_decreased_susceptibility_to0.74762268
149MP0005195_abnormal_posterior_eye0.74401411
150MP0000230_abnormal_systemic_arterial0.74377995
151MP0000026_abnormal_inner_ear0.74245527
152MP0002095_abnormal_skin_pigmentation0.74110170
153MP0008875_abnormal_xenobiotic_pharmacok0.72820605
154MP0001845_abnormal_inflammatory_respons0.72124157
155MP0003183_abnormal_peptide_metabolism0.72111471
156MP0005409_darkened_coat_color0.71965929
157MP0001188_hyperpigmentation0.71726590
158MP0001324_abnormal_eye_pigmentation0.70992890
159MP0005369_muscle_phenotype0.70906718
160MP0005389_reproductive_system_phenotype0.70813014
161MP0003119_abnormal_digestive_system0.69331292
162MP0003123_paternal_imprinting0.68892707
163MP0005365_abnormal_bile_salt0.65895145
164MP0002751_abnormal_autonomic_nervous0.65890385

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.70104109
2Hepatocellular necrosis (HP:0001404)5.64143826
3Hepatic necrosis (HP:0002605)5.61441169
4Mitochondrial inheritance (HP:0001427)5.56653939
5Abnormal mitochondria in muscle tissue (HP:0008316)5.41430724
6Increased CSF lactate (HP:0002490)4.90489011
7Acute encephalopathy (HP:0006846)4.78769410
8Increased hepatocellular lipid droplets (HP:0006565)4.72887714
9Progressive macrocephaly (HP:0004481)4.53459242
10Lipid accumulation in hepatocytes (HP:0006561)4.52268489
11Renal Fanconi syndrome (HP:0001994)4.34686654
12Increased intramyocellular lipid droplets (HP:0012240)4.28888517
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.25444035
14Increased muscle lipid content (HP:0009058)3.94306796
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.85128701
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.85128701
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.75958269
183-Methylglutaconic aciduria (HP:0003535)3.65924693
19Increased serum lactate (HP:0002151)3.63972900
20Lactic acidosis (HP:0003128)3.63487069
21Exertional dyspnea (HP:0002875)3.53151763
22Cerebral edema (HP:0002181)3.49052179
23Exercise intolerance (HP:0003546)3.48664115
24Respiratory failure (HP:0002878)3.44179633
25Abnormality of glycolysis (HP:0004366)3.36541071
26Increased serum pyruvate (HP:0003542)3.36541071
27Generalized aminoaciduria (HP:0002909)3.27828320
28Colon cancer (HP:0003003)3.16613607
29Type I transferrin isoform profile (HP:0003642)3.03906164
30Hyperglycinemia (HP:0002154)2.98118400
31Glycosuria (HP:0003076)2.97267661
32Abnormality of urine glucose concentration (HP:0011016)2.97267661
33Leukodystrophy (HP:0002415)2.94337538
34Abnormal number of erythroid precursors (HP:0012131)2.93351977
35Abnormality of cells of the erythroid lineage (HP:0012130)2.92752629
36Dicarboxylic aciduria (HP:0003215)2.88992008
37Abnormality of dicarboxylic acid metabolism (HP:0010995)2.88992008
38Respiratory difficulties (HP:0002880)2.88826430
39Abnormality of renal resorption (HP:0011038)2.80530169
40Medial flaring of the eyebrow (HP:0010747)2.74007623
41Neuroendocrine neoplasm (HP:0100634)2.70682970
42CNS demyelination (HP:0007305)2.60579438
43Optic disc pallor (HP:0000543)2.59142624
44Pancreatic fibrosis (HP:0100732)2.57615280
45Hyperglycinuria (HP:0003108)2.53015530
46Abnormality of fatty-acid metabolism (HP:0004359)2.50570859
47Methylmalonic aciduria (HP:0012120)2.49295611
48Pancreatic cysts (HP:0001737)2.48217076
49Calf muscle hypertrophy (HP:0008981)2.46398921
50Abnormal protein glycosylation (HP:0012346)2.43815917
51Abnormal glycosylation (HP:0012345)2.43815917
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43815917
53Abnormal protein N-linked glycosylation (HP:0012347)2.43815917
54Muscle hypertrophy of the lower extremities (HP:0008968)2.42792493
55Abnormality of serine family amino acid metabolism (HP:0010894)2.41211901
56Abnormality of glycine metabolism (HP:0010895)2.41211901
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39242101
58Abnormality of alanine metabolism (HP:0010916)2.39242101
59Hyperalaninemia (HP:0003348)2.39242101
60Abnormality of serum amino acid levels (HP:0003112)2.36152226
61Methylmalonic acidemia (HP:0002912)2.33789017
62Palpitations (HP:0001962)2.33647158
63Abnormality of the anterior horn cell (HP:0006802)2.33380825
64Degeneration of anterior horn cells (HP:0002398)2.33380825
65Congenital primary aphakia (HP:0007707)2.33380360
66Hypoglycemic coma (HP:0001325)2.32932150
67True hermaphroditism (HP:0010459)2.30770590
68Abnormality of the labia minora (HP:0012880)2.29144907
69Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.28654140
70Abnormality of midbrain morphology (HP:0002418)2.27073841
71Molar tooth sign on MRI (HP:0002419)2.27073841
72Hyperphosphaturia (HP:0003109)2.27023526
73Aplastic anemia (HP:0001915)2.26544943
74Lethargy (HP:0001254)2.25277004
75Pheochromocytoma (HP:0002666)2.22724343
76Septo-optic dysplasia (HP:0100842)2.20232837
77Microvesicular hepatic steatosis (HP:0001414)2.19708642
78Emotional lability (HP:0000712)2.18033485
79Gait imbalance (HP:0002141)2.15742906
80Reticulocytopenia (HP:0001896)2.13515555
81Nephrogenic diabetes insipidus (HP:0009806)2.13379139
82Myoglobinuria (HP:0002913)2.11861184
83Reduced antithrombin III activity (HP:0001976)2.11333873
84Hypothermia (HP:0002045)2.10300534
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07826912
86Abolished electroretinogram (ERG) (HP:0000550)2.07616773
87Vacuolated lymphocytes (HP:0001922)2.05631321
88Cerebral hypomyelination (HP:0006808)1.98757428
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98009745
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96452197
91Genital tract atresia (HP:0001827)1.95326483
92X-linked dominant inheritance (HP:0001423)1.95221865
93Type 2 muscle fiber atrophy (HP:0003554)1.94464760
94Cerebral hemorrhage (HP:0001342)1.91326057
95Vaginal atresia (HP:0000148)1.88145435
96Renal tubular dysfunction (HP:0000124)1.86850043
97Type II lissencephaly (HP:0007260)1.86802943
98Proximal tubulopathy (HP:0000114)1.86738465
99Macrocytic anemia (HP:0001972)1.86466120
100Cerebellar dysplasia (HP:0007033)1.86454365
101Ragged-red muscle fibers (HP:0003200)1.85470907
102Oral leukoplakia (HP:0002745)1.85092370
103Petechiae (HP:0000967)1.84969582
104Abnormal urine phosphate concentration (HP:0012599)1.84719325
105Stenosis of the external auditory canal (HP:0000402)1.84613095
106Prolonged neonatal jaundice (HP:0006579)1.83997063
107Exercise-induced muscle cramps (HP:0003710)1.83869325
108Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83418680
109Parakeratosis (HP:0001036)1.82153533
110Hyperinsulinemic hypoglycemia (HP:0000825)1.79906288
111Nephronophthisis (HP:0000090)1.79770753
112Intestinal atresia (HP:0011100)1.76384645
113Nemaline bodies (HP:0003798)1.76140182
114Vomiting (HP:0002013)1.75495931
115Bifid tongue (HP:0010297)1.75345291
116Spastic paraparesis (HP:0002313)1.74880951
117Meckel diverticulum (HP:0002245)1.74335498
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.73222336
119Sclerocornea (HP:0000647)1.72922894
120Abnormality of methionine metabolism (HP:0010901)1.72865716
121Absent septum pellucidum (HP:0001331)1.70799770
122Abnormality of the ileum (HP:0001549)1.70532924
123Gliosis (HP:0002171)1.70302469
124Multiple enchondromatosis (HP:0005701)1.70141749
125Elevated erythrocyte sedimentation rate (HP:0003565)1.70112597
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.69917023
127Rhabdomyolysis (HP:0003201)1.68888195
128Ketoacidosis (HP:0001993)1.67796425
129Aplasia/hypoplasia of the uterus (HP:0008684)1.67440061
130Renal cortical cysts (HP:0000803)1.66594382
131Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.65973056
132Muscle fiber atrophy (HP:0100295)1.64855393
133Gastrointestinal stroma tumor (HP:0100723)1.64312787
134Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.63910267
135Dilated cardiomyopathy (HP:0001644)1.63661585
136Blindness (HP:0000618)1.63535159
137Muscle fiber inclusion bodies (HP:0100299)1.62736678
138Neutropenia (HP:0001875)1.62053751
139Metabolic acidosis (HP:0001942)1.59286808
140Poor head control (HP:0002421)1.58699076
141Pancytopenia (HP:0001876)1.58169924
142Abnormal pupillary function (HP:0007686)1.56659707
143Patchy hypopigmentation of hair (HP:0011365)1.56442636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.53822417
2VRK23.61954981
3NME23.58106585
4MAP4K22.76342976
5MUSK2.68504896
6BUB12.66301442
7MYLK2.57343859
8OBSCN2.52832736
9BCKDK2.35213808
10PIK3CG2.33003792
11VRK12.32826407
12NEK12.25897261
13NUAK12.20351621
14TRIM282.12707488
15NME12.11699654
16MAP3K122.07634222
17WNK32.06844711
18CDK191.93184864
19TNIK1.87471585
20PLK31.85821090
21PIM21.79603602
22STK391.79597402
23FLT31.79550296
24TAOK31.76057098
25MKNK21.67179772
26CDC71.64282255
27IRAK41.58039262
28KIT1.57381168
29EIF2AK31.53166617
30PBK1.52971941
31OXSR11.48766919
32MAP3K41.45900885
33GRK11.41408130
34TEC1.37202552
35ARAF1.35385085
36KDR1.33312080
37ZAK1.30434743
38MST41.24203875
39PLK21.21401620
40CCNB11.20945227
41BCR1.18002633
42MAP2K71.15301207
43FRK1.14540476
44WEE11.13035950
45MAPKAPK51.12696629
46TTK1.11426994
47ERBB31.10414511
48PLK11.08195480
49ADRBK21.05265598
50CDK81.03756757
51PASK1.02539160
52STK38L1.02300813
53CSNK1G21.01893957
54BMPR1B1.01798172
55BTK1.01048630
56GRK71.00748340
57CLK10.98936787
58ACVR1B0.97053028
59TXK0.97003419
60TIE10.95935129
61EIF2AK10.95806563
62PDK20.94467018
63LIMK10.92826625
64BRSK20.92050170
65MAP4K10.91837138
66IRAK10.90981177
67PINK10.87453263
68WNK40.86890794
69CSNK1G30.85893961
70TGFBR10.84601548
71MAP3K140.83914993
72TESK20.83221686
73SYK0.80377210
74TAF10.78189178
75IRAK30.76519563
76CSNK1A1L0.76323820
77BRAF0.75975909
78TYK20.75025542
79TSSK60.74920634
80BMPR20.74136693
81AURKB0.73791039
82IKBKE0.73545933
83ILK0.72352707
84BLK0.69530701
85IRAK20.68256469
86SRPK10.66779668
87DYRK20.66492033
88EIF2AK20.65441574
89PHKG10.64305638
90PHKG20.64305638
91RPS6KA50.64254555
92TBK10.63875820
93NLK0.63342498
94MAPK150.63095300
95CAMK2D0.62630384
96INSRR0.60464939
97RPS6KA40.58827011
98PLK40.58580945
99ERBB40.58501838
100MAP2K60.58401575
101PAK40.57910160
102LYN0.57671979
103ZAP700.57108550
104DYRK30.56442130
105STK30.56367131
106ABL20.55422671
107DAPK10.54977324
108CAMK2G0.54681659
109TLK10.54516908
110PRKG20.54511950
111CAMK2B0.52202425
112PRKCQ0.52140309
113IKBKB0.51749670
114MAPKAPK30.51660341
115ATR0.51556588
116CSF1R0.50515146
117MAP3K110.50432327
118PRKCE0.50226380
119PRKCG0.50112107
120MAP2K30.47728047
121TESK10.47658300
122EPHA40.45978192
123PIK3CA0.45601241
124AURKA0.44839502
125CSNK1G10.44589104
126CHEK20.44289673
127CSNK1A10.42300103
128CSNK2A10.41840278
129PKN10.40467344
130MKNK10.39535306
131ITK0.39106217
132LCK0.39090555
133CASK0.38539803
134MAPK130.38503819
135ATM0.38110969
136STK40.37235820
137STK240.37199085
138TRPM70.36811113
139DAPK30.36112293
140CSNK2A20.35187747
141NEK60.34802206
142MAPK40.34222023
143CAMK2A0.30329136
144CDK90.28958528

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.70245674
2Parkinsons disease_Homo sapiens_hsa050124.24545468
3Protein export_Homo sapiens_hsa030603.98431775
4Proteasome_Homo sapiens_hsa030503.82516243
5Ribosome_Homo sapiens_hsa030103.52821689
6Alzheimers disease_Homo sapiens_hsa050102.94820171
7Huntingtons disease_Homo sapiens_hsa050162.76420187
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.73514340
9RNA polymerase_Homo sapiens_hsa030202.70274428
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28955150
11Fatty acid elongation_Homo sapiens_hsa000622.28715039
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.20702423
13DNA replication_Homo sapiens_hsa030302.18846614
14Sulfur metabolism_Homo sapiens_hsa009201.97673460
15Pyrimidine metabolism_Homo sapiens_hsa002401.85030478
16Mismatch repair_Homo sapiens_hsa034301.75222910
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73348055
18Cardiac muscle contraction_Homo sapiens_hsa042601.71562287
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62571854
20Folate biosynthesis_Homo sapiens_hsa007901.59717379
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55474280
22Propanoate metabolism_Homo sapiens_hsa006401.47667844
23Base excision repair_Homo sapiens_hsa034101.46984376
24Homologous recombination_Homo sapiens_hsa034401.45887929
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41848607
26Nucleotide excision repair_Homo sapiens_hsa034201.33147732
27One carbon pool by folate_Homo sapiens_hsa006701.26426527
28Peroxisome_Homo sapiens_hsa041461.21867299
29Purine metabolism_Homo sapiens_hsa002301.21080912
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19503243
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14840586
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12349170
33Pyruvate metabolism_Homo sapiens_hsa006201.11383711
34Glutathione metabolism_Homo sapiens_hsa004801.06332193
35Fatty acid degradation_Homo sapiens_hsa000711.02675090
36Metabolic pathways_Homo sapiens_hsa011001.01737186
37Carbon metabolism_Homo sapiens_hsa012001.00571398
38Non-homologous end-joining_Homo sapiens_hsa034500.98954619
39Steroid biosynthesis_Homo sapiens_hsa001000.96156485
40Nitrogen metabolism_Homo sapiens_hsa009100.92889448
41Spliceosome_Homo sapiens_hsa030400.91892735
42Basal transcription factors_Homo sapiens_hsa030220.90915589
43Sulfur relay system_Homo sapiens_hsa041220.90632859
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88914167
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88708634
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.87054105
47Histidine metabolism_Homo sapiens_hsa003400.85641253
48Selenocompound metabolism_Homo sapiens_hsa004500.83856561
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81247530
50RNA degradation_Homo sapiens_hsa030180.80677663
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78764282
52Caffeine metabolism_Homo sapiens_hsa002320.78671241
53Fatty acid metabolism_Homo sapiens_hsa012120.78443522
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.78384896
55Pentose phosphate pathway_Homo sapiens_hsa000300.78153862
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76104034
57Arachidonic acid metabolism_Homo sapiens_hsa005900.75337245
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74640330
59Primary immunodeficiency_Homo sapiens_hsa053400.74046348
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71483898
61Phototransduction_Homo sapiens_hsa047440.70639274
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70412279
63Arginine and proline metabolism_Homo sapiens_hsa003300.68589220
64Regulation of autophagy_Homo sapiens_hsa041400.65403430
65Vibrio cholerae infection_Homo sapiens_hsa051100.59846168
66Galactose metabolism_Homo sapiens_hsa000520.59798866
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59273794
68Butanoate metabolism_Homo sapiens_hsa006500.58572574
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58128012
70Fat digestion and absorption_Homo sapiens_hsa049750.57510754
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.56456788
72N-Glycan biosynthesis_Homo sapiens_hsa005100.56352991
73Allograft rejection_Homo sapiens_hsa053300.55256103
74Retinol metabolism_Homo sapiens_hsa008300.54597322
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.53308122
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53059506
77Asthma_Homo sapiens_hsa053100.52662423
78Tyrosine metabolism_Homo sapiens_hsa003500.51328610
79Sphingolipid metabolism_Homo sapiens_hsa006000.51116400
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49084899
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48834908
82Other glycan degradation_Homo sapiens_hsa005110.47938004
83Linoleic acid metabolism_Homo sapiens_hsa005910.47928686
84Collecting duct acid secretion_Homo sapiens_hsa049660.47721114
85Ether lipid metabolism_Homo sapiens_hsa005650.46482424
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46407096
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.43791814
88Phenylalanine metabolism_Homo sapiens_hsa003600.43639276
89Fructose and mannose metabolism_Homo sapiens_hsa000510.43200558
90beta-Alanine metabolism_Homo sapiens_hsa004100.41680726
91Autoimmune thyroid disease_Homo sapiens_hsa053200.41650483
92Chemical carcinogenesis_Homo sapiens_hsa052040.41231069
93Vitamin digestion and absorption_Homo sapiens_hsa049770.38909939
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37303664
95Rheumatoid arthritis_Homo sapiens_hsa053230.37043196
96Biosynthesis of amino acids_Homo sapiens_hsa012300.36813262
97Tryptophan metabolism_Homo sapiens_hsa003800.36054144
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33606359
99Fanconi anemia pathway_Homo sapiens_hsa034600.33545161
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33490584
101Cell cycle_Homo sapiens_hsa041100.32918307
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31122684
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30127299
104RNA transport_Homo sapiens_hsa030130.29738808
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28809230
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28202519
107Vitamin B6 metabolism_Homo sapiens_hsa007500.26263213
108Starch and sucrose metabolism_Homo sapiens_hsa005000.25076790
109Hematopoietic cell lineage_Homo sapiens_hsa046400.24295745
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24050776
111Epstein-Barr virus infection_Homo sapiens_hsa051690.23749492
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23558389
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21941414
114p53 signaling pathway_Homo sapiens_hsa041150.21914483
115Oocyte meiosis_Homo sapiens_hsa041140.21848447
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21367424
117mRNA surveillance pathway_Homo sapiens_hsa030150.20559457
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17449694
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.16416489
120Legionellosis_Homo sapiens_hsa051340.16378540

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