SMIM12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.03004432
2ATP synthesis coupled proton transport (GO:0015986)7.60356810
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.60356810
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.79438336
5respiratory electron transport chain (GO:0022904)6.41857094
6electron transport chain (GO:0022900)6.28183034
7chaperone-mediated protein transport (GO:0072321)5.66186927
8oxidative phosphorylation (GO:0006119)5.13503597
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.12370987
10mitochondrial respiratory chain complex I assembly (GO:0032981)5.12370987
11NADH dehydrogenase complex assembly (GO:0010257)5.12370987
12protein complex biogenesis (GO:0070271)5.06569970
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.94784631
14proteasome assembly (GO:0043248)4.92697615
15protein neddylation (GO:0045116)4.87627883
16mitochondrial respiratory chain complex assembly (GO:0033108)4.69824701
17cullin deneddylation (GO:0010388)4.35392173
18ATP biosynthetic process (GO:0006754)4.33712801
19hydrogen ion transmembrane transport (GO:1902600)4.24401744
20respiratory chain complex IV assembly (GO:0008535)4.18635028
21protein targeting to mitochondrion (GO:0006626)4.18506506
22establishment of protein localization to mitochondrion (GO:0072655)4.14057798
23purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.12801667
24protein deneddylation (GO:0000338)4.11983898
25regulation of cellular amino acid metabolic process (GO:0006521)4.09543643
26purine nucleoside triphosphate biosynthetic process (GO:0009145)4.08688525
27inner mitochondrial membrane organization (GO:0007007)4.08455231
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.93485225
29dopamine transport (GO:0015872)3.91404811
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.89297960
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.89297960
32protein localization to mitochondrion (GO:0070585)3.88541261
33DNA deamination (GO:0045006)3.88168601
34platelet dense granule organization (GO:0060155)3.86916237
35cytochrome complex assembly (GO:0017004)3.85439665
36pseudouridine synthesis (GO:0001522)3.83669260
37rRNA modification (GO:0000154)3.80583674
38ribonucleoside triphosphate biosynthetic process (GO:0009201)3.75944051
39regulation of mitochondrial translation (GO:0070129)3.74263733
40L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.74258823
41proton transport (GO:0015992)3.72382597
42ribosomal small subunit assembly (GO:0000028)3.71034914
43ATP hydrolysis coupled proton transport (GO:0015991)3.70400186
44energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.70400186
45regulation of cellular respiration (GO:0043457)3.66883487
46DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66179231
47peptidyl-histidine modification (GO:0018202)3.65777958
48hydrogen transport (GO:0006818)3.64116779
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.60732897
50negative regulation of ligase activity (GO:0051352)3.60732897
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.57169653
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.55141165
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.55141165
54ribosomal small subunit biogenesis (GO:0042274)3.55068150
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.53462918
56termination of RNA polymerase III transcription (GO:0006386)3.53462918
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51913335
58aerobic respiration (GO:0009060)3.49575234
59viral transcription (GO:0019083)3.49275654
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.48661354
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.48661354
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.48661354
63GTP biosynthetic process (GO:0006183)3.39612701
64tricarboxylic acid cycle (GO:0006099)3.38849422
65nucleoside triphosphate biosynthetic process (GO:0009142)3.38268017
66sequestering of actin monomers (GO:0042989)3.37694591
67signal transduction involved in DNA integrity checkpoint (GO:0072401)3.35493566
68signal transduction involved in DNA damage checkpoint (GO:0072422)3.35493566
69guanosine-containing compound biosynthetic process (GO:1901070)3.35352605
70translational termination (GO:0006415)3.35305390
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.34400696
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33858540
73positive regulation of mitochondrial fission (GO:0090141)3.32541070
74mannosylation (GO:0097502)3.31528629
75maturation of 5.8S rRNA (GO:0000460)3.30792714
76NADH metabolic process (GO:0006734)3.30648472
77antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.29309475
78protein-cofactor linkage (GO:0018065)3.28770238
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.28580674
80mitochondrial transport (GO:0006839)3.28502552
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27169473
82regulation of cellular amine metabolic process (GO:0033238)3.25075136
83ubiquinone biosynthetic process (GO:0006744)3.24708001
84quinone biosynthetic process (GO:1901663)3.24708001
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23826255
86rRNA methylation (GO:0031167)3.23825334
87base-excision repair, AP site formation (GO:0006285)3.23518646
88purine nucleoside monophosphate biosynthetic process (GO:0009127)3.22629196
89purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.22629196
90mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.21711333
91RNA capping (GO:0036260)3.20946348
927-methylguanosine RNA capping (GO:0009452)3.20946348
937-methylguanosine mRNA capping (GO:0006370)3.20655582
94regulation of oxidative phosphorylation (GO:0002082)3.20097301
95translational elongation (GO:0006414)3.18466512
96translation (GO:0006412)3.12687338
97negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.12051226
98kynurenine metabolic process (GO:0070189)3.09473590
99cotranslational protein targeting to membrane (GO:0006613)3.03525004
100nucleobase-containing small molecule interconversion (GO:0015949)3.01780387
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.01026951
102positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98776486
103amino acid salvage (GO:0043102)2.97318272
104L-methionine salvage (GO:0071267)2.97318272
105L-methionine biosynthetic process (GO:0071265)2.97318272
106maturation of SSU-rRNA (GO:0030490)2.97121396
107pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.96638624
108iron-sulfur cluster assembly (GO:0016226)2.96295096
109metallo-sulfur cluster assembly (GO:0031163)2.96295096
110protein targeting to ER (GO:0045047)2.96148450
111ubiquinone metabolic process (GO:0006743)2.92565250
112tRNA processing (GO:0008033)2.92490503
113protein localization to endoplasmic reticulum (GO:0070972)2.92197965
114indolalkylamine catabolic process (GO:0046218)2.88864773
115tryptophan catabolic process (GO:0006569)2.88864773
116indole-containing compound catabolic process (GO:0042436)2.88864773
117signal peptide processing (GO:0006465)2.88264369
118preassembly of GPI anchor in ER membrane (GO:0016254)2.84956786
119positive regulation of ligase activity (GO:0051351)2.77287628
120negative regulation of mast cell activation (GO:0033004)2.68840547
121mitochondrial RNA metabolic process (GO:0000959)2.68161203
122deoxyribonucleotide catabolic process (GO:0009264)2.65925591
123purine nucleotide salvage (GO:0032261)2.56538763
124cellular ketone body metabolic process (GO:0046950)2.56410967
125dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.52990133
126tryptophan metabolic process (GO:0006568)2.52936715
127amine catabolic process (GO:0009310)2.51690476
128cellular biogenic amine catabolic process (GO:0042402)2.51690476
129negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.51492415
130methionine biosynthetic process (GO:0009086)2.51435378
131indolalkylamine metabolic process (GO:0006586)2.49813941
132DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.49597430
133water-soluble vitamin biosynthetic process (GO:0042364)2.49075973
134positive regulation of prostaglandin secretion (GO:0032308)2.48669316
135C-terminal protein lipidation (GO:0006501)2.47378295
136deoxyribose phosphate catabolic process (GO:0046386)2.46967750
137tRNA metabolic process (GO:0006399)2.46305108
138organelle membrane fusion (GO:0090174)2.45347212
139positive regulation of cell cycle arrest (GO:0071158)2.44407506
140purine-containing compound salvage (GO:0043101)2.43332396
141tRNA modification (GO:0006400)2.42198010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.09770955
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.53715747
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.36017985
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.34183577
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.13279197
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.09629333
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.95047122
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.81681790
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.73311490
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.56010743
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.51311035
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.39784731
13THAP11_20581084_ChIP-Seq_MESCs_Mouse3.04298320
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00937197
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.99737571
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.87235134
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.80154830
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.73298567
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70797992
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.68532756
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61859880
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.61282895
23DCP1A_22483619_ChIP-Seq_HELA_Human2.51381197
24YY1_21170310_ChIP-Seq_MESCs_Mouse2.47161187
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41609347
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.38601302
27NOTCH1_21737748_ChIP-Seq_TLL_Human2.38323479
28VDR_23849224_ChIP-Seq_CD4+_Human2.32728861
29XRN2_22483619_ChIP-Seq_HELA_Human2.29711122
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25423973
31IRF8_22096565_ChIP-ChIP_GC-B_Human2.17214712
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.14907670
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.11977490
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11322424
35FOXP3_21729870_ChIP-Seq_TREG_Human2.02101205
36ZNF274_21170338_ChIP-Seq_K562_Hela1.97675265
37GABP_19822575_ChIP-Seq_HepG2_Human1.93783370
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91117407
39TTF2_22483619_ChIP-Seq_HELA_Human1.88878978
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.82219058
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74770235
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74226629
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67045124
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56335068
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55565034
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51121108
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49480945
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48281017
49ELK1_19687146_ChIP-ChIP_HELA_Human1.47591209
50CTCF_18555785_ChIP-Seq_MESCs_Mouse1.42458652
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41607796
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37717905
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34612115
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.34606278
55CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.33365782
56TAF15_26573619_Chip-Seq_HEK293_Human1.31868625
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31391931
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29348554
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28348484
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28317846
61KDM5A_27292631_Chip-Seq_BREAST_Human1.26249312
62VDR_22108803_ChIP-Seq_LS180_Human1.26016514
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18028468
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17293071
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17271720
66TFEB_21752829_ChIP-Seq_HELA_Human1.15266985
67GATA3_26560356_Chip-Seq_TH2_Human1.15083403
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14951941
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14048988
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.11482517
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11480482
72MYC_18940864_ChIP-ChIP_HL60_Human1.11202489
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10960293
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10394528
75SPI1_23547873_ChIP-Seq_NB4_Human1.09446839
76TP53_22573176_ChIP-Seq_HFKS_Human1.09262232
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09126708
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07683856
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04575982
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01328824
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01260615
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00104315
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99414954
84IRF1_19129219_ChIP-ChIP_H3396_Human0.99066416
85STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98929757
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96915861
87PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95660719
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95587565
89NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93531026
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91964467
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91485804
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91402032
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.90418145
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90245021
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89000504
96AR_20517297_ChIP-Seq_VCAP_Human0.88658439
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88616205
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85848872
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.85848872
100MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85537264
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85020041
102MYB_26560356_Chip-Seq_TH2_Human0.84947890
103TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84920457
104GATA3_21878914_ChIP-Seq_MCF-7_Human0.84715515
105NANOG_20526341_ChIP-Seq_ESCs_Human0.84069936
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83813877
107STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83738770
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82813592
109TET1_21451524_ChIP-Seq_MESCs_Mouse0.82763951
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82602033
111STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.82554560
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82431996
113EZH2_22144423_ChIP-Seq_EOC_Human0.81963499
114TAF2_19829295_ChIP-Seq_ESCs_Human0.80745294
115STAT1_20625510_ChIP-Seq_HELA_Human0.80682396
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80323760
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80015313
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79881315
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79315010
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79296330
121CIITA_25753668_ChIP-Seq_RAJI_Human0.78779980
122NCOR_22424771_ChIP-Seq_293T_Human0.77213442
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.77030689
124MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.76733445
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75258621
126KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74834358
127SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74294508
128SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73420650
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.73299257
130* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72354920
131SOX17_20123909_ChIP-Seq_XEN_Mouse0.71285687
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70549375
133FOXP1_21924763_ChIP-Seq_HESCs_Human0.69413270
134BCL6_27268052_Chip-Seq_Bcells_Human0.68289545
135MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.68090619
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.67495667
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.66614318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.15320366
2MP0001529_abnormal_vocalization3.51379134
3MP0001905_abnormal_dopamine_level3.07495604
4MP0006036_abnormal_mitochondrial_physio3.05040525
5MP0003646_muscle_fatigue3.03653190
6MP0002822_catalepsy2.99336597
7MP0002837_dystrophic_cardiac_calcinosis2.97680567
8MP0002736_abnormal_nociception_after2.91643830
9MP0003195_calcinosis2.82454918
10MP0001968_abnormal_touch/_nociception2.74570542
11MP0002735_abnormal_chemical_nociception2.57456245
12MP0006035_abnormal_mitochondrial_morpho2.55864873
13MP0006276_abnormal_autonomic_nervous2.48682947
14MP0000749_muscle_degeneration2.43939272
15MP0000015_abnormal_ear_pigmentation2.35179897
16MP0009379_abnormal_foot_pigmentation2.34265722
17MP0004142_abnormal_muscle_tone2.27308380
18MP0005671_abnormal_response_to2.27154491
19MP0003186_abnormal_redox_activity2.26801915
20MP0003806_abnormal_nucleotide_metabolis2.21519816
21MP0009745_abnormal_behavioral_response2.17532925
22MP0002148_abnormal_hypersensitivity_rea2.12840263
23MP0009785_altered_susceptibility_to2.11655352
24MP0009046_muscle_twitch2.11225425
25MP0002064_seizures2.09115684
26MP0004859_abnormal_synaptic_plasticity2.02610242
27MP0002272_abnormal_nervous_system2.01174314
28MP0002138_abnormal_hepatobiliary_system1.97458689
29MP0008058_abnormal_DNA_repair1.90700377
30MP0001835_abnormal_antigen_presentation1.90494793
31MP0005410_abnormal_fertilization1.89590444
32MP0003635_abnormal_synaptic_transmissio1.83581572
33MP0002139_abnormal_hepatobiliary_system1.83063671
34MP0009764_decreased_sensitivity_to1.81339693
35MP0004036_abnormal_muscle_relaxation1.79901743
36MP0002733_abnormal_thermal_nociception1.78423998
37MP0001984_abnormal_olfaction1.77648237
38MP0001970_abnormal_pain_threshold1.77443574
39MP0000751_myopathy1.77299143
40MP0004147_increased_porphyrin_level1.74471263
41MP0005174_abnormal_tail_pigmentation1.71351882
42MP0004084_abnormal_cardiac_muscle1.68991980
43MP0005075_abnormal_melanosome_morpholog1.67466871
44MP0002332_abnormal_exercise_endurance1.66930967
45MP0002734_abnormal_mechanical_nocicepti1.64717271
46MP0004215_abnormal_myocardial_fiber1.58567454
47MP0004270_analgesia1.57819825
48MP0008872_abnormal_physiological_respon1.54026494
49MP0005058_abnormal_lysosome_morphology1.46056817
50MP0009840_abnormal_foam_cell1.45995131
51MP0005387_immune_system_phenotype1.44438340
52MP0001790_abnormal_immune_system1.44438340
53MP0002254_reproductive_system_inflammat1.44329448
54MP0002572_abnormal_emotion/affect_behav1.43886427
55MP0001440_abnormal_grooming_behavior1.42309733
56MP0003724_increased_susceptibility_to1.41432829
57MP0005000_abnormal_immune_tolerance1.40800555
58MP0006072_abnormal_retinal_apoptosis1.39490435
59MP0003221_abnormal_cardiomyocyte_apopto1.37091465
60MP0005330_cardiomyopathy1.36042602
61MP0002063_abnormal_learning/memory/cond1.35817939
62MP0003693_abnormal_embryo_hatching1.34785852
63MP0006082_CNS_inflammation1.34483846
64MP0005451_abnormal_body_composition1.34482436
65MP0000685_abnormal_immune_system1.34472096
66MP0002723_abnormal_immune_serum1.32695860
67MP0005386_behavior/neurological_phenoty1.32424226
68MP0004924_abnormal_behavior1.32424226
69MP0001501_abnormal_sleep_pattern1.31653030
70MP0001986_abnormal_taste_sensitivity1.30636581
71MP0005332_abnormal_amino_acid1.30463597
72MP0002452_abnormal_antigen_presenting1.29371453
73MP0001853_heart_inflammation1.29251647
74MP0004145_abnormal_muscle_electrophysio1.26277908
75MP0005025_abnormal_response_to1.25013739
76MP0002067_abnormal_sensory_capabilities1.23819802
77MP0001800_abnormal_humoral_immune1.23787761
78MP0008260_abnormal_autophagy1.23029183
79MP0005266_abnormal_metabolism1.22067785
80MP0005409_darkened_coat_color1.21668435
81MP0002972_abnormal_cardiac_muscle1.21224946
82MP0005379_endocrine/exocrine_gland_phen1.20556656
83MP0008007_abnormal_cellular_replicative1.20072847
84MP0005551_abnormal_eye_electrophysiolog1.16841456
85MP0002102_abnormal_ear_morphology1.16166352
86MP0004484_altered_response_of1.15992379
87MP0002693_abnormal_pancreas_physiology1.15593944
88MP0008469_abnormal_protein_level1.15538491
89MP0000358_abnormal_cell_content/1.15409921
90MP0002419_abnormal_innate_immunity1.14466035
91MP0005253_abnormal_eye_physiology1.14160165
92MP0005083_abnormal_biliary_tract1.12738796
93MP0001845_abnormal_inflammatory_respons1.12594489
94MP0002420_abnormal_adaptive_immunity1.11734107
95MP0001819_abnormal_immune_cell1.10811778
96MP0003122_maternal_imprinting1.10599825
97MP0008932_abnormal_embryonic_tissue1.09502692
98MP0004957_abnormal_blastocyst_morpholog1.09355007
99MP0005670_abnormal_white_adipose1.08076011
100MP0000371_diluted_coat_color1.07470960
101MP0010094_abnormal_chromosome_stability1.07313986
102MP0002184_abnormal_innervation1.07259392
103MP0000343_altered_response_to1.06510517
104MP0005423_abnormal_somatic_nervous1.05029641
105MP0000747_muscle_weakness1.04779881
106MP0002876_abnormal_thyroid_physiology1.04333531
107MP0009697_abnormal_copulation1.04210958
108MP0002095_abnormal_skin_pigmentation1.03193535
109MP0005084_abnormal_gallbladder_morpholo1.02568908
110MP0008875_abnormal_xenobiotic_pharmacok1.01861390
111MP0005408_hypopigmentation1.00221329
112MP0005464_abnormal_platelet_physiology0.99667935
113MP0005636_abnormal_mineral_homeostasis0.98791342
114MP0001486_abnormal_startle_reflex0.97924024
115MP0003136_yellow_coat_color0.97655676
116MP0005365_abnormal_bile_salt0.94723506
117MP0005319_abnormal_enzyme/_coenzyme0.94250725
118MP0000689_abnormal_spleen_morphology0.94006680
119MP0005310_abnormal_salivary_gland0.93867083
120MP0003436_decreased_susceptibility_to0.93783238
121MP0005620_abnormal_muscle_contractility0.93213464
122MP0004043_abnormal_pH_regulation0.92971429
123MP0005397_hematopoietic_system_phenotyp0.92834100
124MP0001545_abnormal_hematopoietic_system0.92834100
125MP0003950_abnormal_plasma_membrane0.92793771
126MP0005584_abnormal_enzyme/coenzyme_acti0.92722223
127MP0002638_abnormal_pupillary_reflex0.91545548
128MP0001764_abnormal_homeostasis0.91349693
129MP0001188_hyperpigmentation0.91164007
130MP0010386_abnormal_urinary_bladder0.90526848
131MP0002269_muscular_atrophy0.90049665
132MP0001919_abnormal_reproductive_system0.89943599
133MP0005389_reproductive_system_phenotype0.88773194
134MP0002751_abnormal_autonomic_nervous0.87037697
135MP0002066_abnormal_motor_capabilities/c0.86379333
136MP0003303_peritoneal_inflammation0.85629536
137MP0005645_abnormal_hypothalamus_physiol0.85340148
138MP0003252_abnormal_bile_duct0.85286464
139MP0003137_abnormal_impulse_conducting0.85119793
140MP0005385_cardiovascular_system_phenoty0.83961514
141MP0001544_abnormal_cardiovascular_syste0.83961514
142MP0003172_abnormal_lysosome_physiology0.83774283
143MP0002277_abnormal_respiratory_mucosa0.83233591
144MP0004811_abnormal_neuron_physiology0.83033620
145MP0000372_irregular_coat_pigmentation0.81748472
146MP0002160_abnormal_reproductive_system0.81435031
147MP0000716_abnormal_immune_system0.80702999
148MP0000569_abnormal_digit_pigmentation0.80174847
149MP0008874_decreased_physiological_sensi0.79931680
150MP0002163_abnormal_gland_morphology0.79196613
151MP0005376_homeostasis/metabolism_phenot0.77239242
152MP0005165_increased_susceptibility_to0.77146055
153MP0002106_abnormal_muscle_physiology0.75942755
154MP0009333_abnormal_splenocyte_physiolog0.75276229
155MP0001727_abnormal_embryo_implantation0.74986415
156MP0004085_abnormal_heartbeat0.74151204
157MP0005535_abnormal_body_temperature0.74031690
158MP0003786_premature_aging0.73131782
159MP0004133_heterotaxia0.72732025
160MP0003718_maternal_effect0.70253719
161MP0008775_abnormal_heart_ventricle0.67884394
162MP0006138_congestive_heart_failure0.67736423
163MP0003123_paternal_imprinting0.67500656
164MP0008877_abnormal_DNA_methylation0.66774560
165MP0003656_abnormal_erythrocyte_physiolo0.66729261
166MP0003879_abnormal_hair_cell0.66496763
167MP0008569_lethality_at_weaning0.64725100
168MP0003329_amyloid_beta_deposits0.64206280
169MP0002229_neurodegeneration0.62874802

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.19547765
2Abnormal mitochondria in muscle tissue (HP:0008316)6.72440694
3Mitochondrial inheritance (HP:0001427)6.31091954
4Acute encephalopathy (HP:0006846)6.00866213
5Progressive macrocephaly (HP:0004481)5.93009523
6Hepatocellular necrosis (HP:0001404)5.88057097
7Increased CSF lactate (HP:0002490)5.57899211
8Hepatic necrosis (HP:0002605)5.17256681
9Increased hepatocellular lipid droplets (HP:0006565)4.46086120
10Abnormality of glycolysis (HP:0004366)4.44236186
11Increased serum pyruvate (HP:0003542)4.44236186
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.38135866
13Cerebral edema (HP:0002181)4.25566386
14Neuroendocrine neoplasm (HP:0100634)4.21854283
15Lipid accumulation in hepatocytes (HP:0006561)4.09481853
16Exercise intolerance (HP:0003546)4.03901421
17Respiratory failure (HP:0002878)4.01162459
18Lactic acidosis (HP:0003128)3.97830186
19Renal Fanconi syndrome (HP:0001994)3.90656725
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.86057329
21Increased serum lactate (HP:0002151)3.81083567
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.77915899
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.77915899
24Pheochromocytoma (HP:0002666)3.77750277
25Increased intramyocellular lipid droplets (HP:0012240)3.74137618
26Optic disc pallor (HP:0000543)3.56157115
27Leukodystrophy (HP:0002415)3.55064977
283-Methylglutaconic aciduria (HP:0003535)3.51906682
29Myokymia (HP:0002411)3.43099029
30Increased muscle lipid content (HP:0009058)3.27865177
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.27401595
32Abnormal protein N-linked glycosylation (HP:0012347)3.27401595
33Abnormal protein glycosylation (HP:0012346)3.27401595
34Abnormal glycosylation (HP:0012345)3.27401595
35Exertional dyspnea (HP:0002875)3.19222047
36Albinism (HP:0001022)3.12185604
37Emotional lability (HP:0000712)3.09713876
38Abnormality of cells of the erythroid lineage (HP:0012130)2.96564824
39Respiratory difficulties (HP:0002880)2.90360648
40CNS demyelination (HP:0007305)2.86184388
41Abnormality of alanine metabolism (HP:0010916)2.81944825
42Hyperalaninemia (HP:0003348)2.81944825
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81944825
44Focal motor seizures (HP:0011153)2.79708819
45Stomatitis (HP:0010280)2.76445158
46Abnormality of glycolipid metabolism (HP:0010969)2.69871690
47Abnormality of liposaccharide metabolism (HP:0010968)2.69871690
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.69871690
49Abnormal number of erythroid precursors (HP:0012131)2.68105536
50Microvesicular hepatic steatosis (HP:0001414)2.63678595
51Cerebral hypomyelination (HP:0006808)2.61581629
52Severe visual impairment (HP:0001141)2.55407675
53Neoplasm of the peripheral nervous system (HP:0100007)2.51236575
54Hypothermia (HP:0002045)2.50960897
55Congenital stationary night blindness (HP:0007642)2.50830247
56Reduced antithrombin III activity (HP:0001976)2.49585194
57Palpitations (HP:0001962)2.46721157
58Generalized aminoaciduria (HP:0002909)2.46050667
59Lethargy (HP:0001254)2.45802131
60Atonic seizures (HP:0010819)2.41823962
61Poor suck (HP:0002033)2.41347029
62Ragged-red muscle fibers (HP:0003200)2.37475123
63Cerebral hemorrhage (HP:0001342)2.35919479
64Abnormality of renal resorption (HP:0011038)2.27377070
65X-linked dominant inheritance (HP:0001423)2.26506529
66Delusions (HP:0000746)2.21647279
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21159508
68Abnormality of midbrain morphology (HP:0002418)2.17771150
69Molar tooth sign on MRI (HP:0002419)2.17771150
70Poor head control (HP:0002421)2.17602240
71Ketoacidosis (HP:0001993)2.17542638
72Vacuolated lymphocytes (HP:0001922)2.16284684
73Pancreatic cysts (HP:0001737)2.14488630
74Limb dystonia (HP:0002451)2.14399585
75Myotonia (HP:0002486)2.13523737
76Pancytopenia (HP:0001876)2.12668031
77Gliosis (HP:0002171)2.12608243
78Opisthotonus (HP:0002179)2.12361124
79Abnormality of the vocal cords (HP:0008777)2.12154774
80Attenuation of retinal blood vessels (HP:0007843)2.11400554
81Abnormal rod and cone electroretinograms (HP:0008323)2.08883262
82Abnormal drinking behavior (HP:0030082)2.05498508
83Polydipsia (HP:0001959)2.05498508
84Ketosis (HP:0001946)2.04135465
85Cholecystitis (HP:0001082)2.02125640
86Abnormal gallbladder physiology (HP:0012438)2.02125640
87Progressive microcephaly (HP:0000253)2.00236277
88Aplasia/Hypoplasia of the fovea (HP:0008060)1.98008427
89Hypoplasia of the fovea (HP:0007750)1.98008427
90Methylmalonic aciduria (HP:0012120)1.96224543
91Abnormal hair whorl (HP:0010721)1.93094806
92Macrocytic anemia (HP:0001972)1.91566895
93Glycosuria (HP:0003076)1.90674934
94Abnormality of urine glucose concentration (HP:0011016)1.90674934
95Progressive external ophthalmoplegia (HP:0000590)1.90651221
96Hyperphosphaturia (HP:0003109)1.90292977
97Unsteady gait (HP:0002317)1.90158782
98Elevated erythrocyte sedimentation rate (HP:0003565)1.90059313
99IgG deficiency (HP:0004315)1.87458591
100Abnormality of serum amino acid levels (HP:0003112)1.87120538
101Hyperventilation (HP:0002883)1.83977143
102Increased neuronal autofluorescent lipopigment (HP:0002074)1.83321427
103Aplastic anemia (HP:0001915)1.82447802
104Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81789630
105Muscle hypertrophy of the lower extremities (HP:0008968)1.79496932
106Vomiting (HP:0002013)1.79171305
107Conjunctival hamartoma (HP:0100780)1.78479521
108Pancreatic fibrosis (HP:0100732)1.78412858
109Nausea (HP:0002018)1.78311837
110Petechiae (HP:0000967)1.78194128
111Pendular nystagmus (HP:0012043)1.77286869
112Large for gestational age (HP:0001520)1.76633149
113Congenital sensorineural hearing impairment (HP:0008527)1.75868472
114Abolished electroretinogram (ERG) (HP:0000550)1.75758445
115Hypokinesia (HP:0002375)1.75173579
116Sensory axonal neuropathy (HP:0003390)1.75130507
117Postnatal microcephaly (HP:0005484)1.75035975
118Hypomagnesemia (HP:0002917)1.74976329
119Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74565382
120Abnormality of the anterior horn cell (HP:0006802)1.72335467
121Degeneration of anterior horn cells (HP:0002398)1.72335467
122CNS hypomyelination (HP:0003429)1.71078931
123Blindness (HP:0000618)1.70996404
124Calf muscle hypertrophy (HP:0008981)1.70592784
125Neoplasm of head and neck (HP:0012288)1.70537090
126Esophageal neoplasm (HP:0100751)1.70537090
127Microretrognathia (HP:0000308)1.70361674
128Rhabdomyolysis (HP:0003201)1.69891085
129Abnormality of the pons (HP:0007361)1.69507742
130Hypoplasia of the pons (HP:0012110)1.68924332
131Type I transferrin isoform profile (HP:0003642)1.68826291
132Tongue fasciculations (HP:0001308)1.68757592
133Cutaneous melanoma (HP:0012056)1.68453147
134Retinal dysplasia (HP:0007973)1.67234804
135Exercise-induced muscle cramps (HP:0003710)1.67141464
136Hyperglycinemia (HP:0002154)1.66870548
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66341688
138Increased cerebral lipofuscin (HP:0011813)1.65223122
139Oral leukoplakia (HP:0002745)1.64864698
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.64750173
141Dicarboxylic aciduria (HP:0003215)1.64750173
142Metabolic acidosis (HP:0001942)1.64435177
143Tinnitus (HP:0000360)1.64434482
144Abnormality of the fovea (HP:0000493)1.64141434
145Abnormal pupillary function (HP:0007686)1.63312223
146Sudden death (HP:0001699)1.62097875
147Absence seizures (HP:0002121)1.61688303
148Renal tubular dysfunction (HP:0000124)1.59941115
149Anxiety (HP:0000739)1.59195755
150Muscle stiffness (HP:0003552)1.56409251
151Dialeptic seizures (HP:0011146)1.56384185
152Reticulocytopenia (HP:0001896)1.55869947
153Methylmalonic acidemia (HP:0002912)1.51556445
154Neoplasm of the adrenal gland (HP:0100631)1.50707275
155Type 2 muscle fiber atrophy (HP:0003554)1.50434098
156Respiratory insufficiency due to muscle weakness (HP:0002747)1.49714193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.22239339
2MAP3K123.80825741
3STK163.45951437
4ARAF3.29961598
5NME22.74600874
6MYLK2.73971520
7BUB12.67252397
8VRK22.49362643
9PDK22.47251266
10NME12.35437177
11TRIM282.33000423
12CDK192.21137310
13GRK52.18268733
14CASK2.10688805
15TXK2.08321149
16LIMK12.03707289
17NUAK11.94003510
18BRAF1.83294883
19MAP2K71.79949869
20EIF2AK11.79607079
21PIM21.77219021
22BCKDK1.71625897
23TESK11.70973750
24TSSK61.69949942
25GRK71.65179598
26MAP4K21.64826618
27TESK21.61375528
28GRK11.57243438
29DAPK11.55292386
30CCNB11.47518968
31WNK31.45677478
32IKBKB1.45563768
33WEE11.43119338
34OBSCN1.42610193
35BMPR1B1.41653807
36VRK11.38541961
37MINK11.36178720
38PLK21.31904696
39EIF2AK31.31822418
40MUSK1.25270556
41MARK31.24940212
42TIE11.22413864
43IRAK31.21572635
44DAPK31.21115652
45MAP3K111.21038541
46KDR1.18263636
47OXSR11.17334980
48RIPK41.15532232
49NEK11.09930718
50DAPK21.02712030
51PRPF4B0.98757151
52ILK0.98519798
53PDK30.98290859
54PDK40.98290859
55TAOK30.98097387
56ABL20.94362725
57CDK80.93782399
58CSNK1G10.93135923
59CAMKK20.92824688
60TNIK0.92499725
61TAOK20.92475546
62MAP2K40.90739980
63AURKA0.89549575
64TLK10.86040825
65NTRK30.85680331
66MAP3K90.84657089
67BMPR20.84150057
68PLK10.83865212
69RAF10.82629360
70PBK0.82275693
71MAP4K10.81963021
72MAPKAPK50.81862744
73MAP2K60.81489547
74CDC70.80804533
75ADRBK20.80302288
76TEC0.80068740
77MST40.80031905
78PTK2B0.78176137
79BRSK10.78116021
80SIK30.77866422
81PRKCI0.77026255
82CDK140.76491011
83CAMK2G0.76426162
84SRPK10.76134614
85GRK60.76083532
86MAPKAPK30.72707573
87PLK40.71486361
88CSNK1A1L0.70453641
89MAP3K40.69162918
90PINK10.69052863
91CSNK1G30.69030049
92MOS0.68717458
93CSNK1G20.68650635
94CAMK2B0.67975621
95KSR20.67506204
96RPS6KA50.67072837
97MAP3K130.66501854
98BCR0.66198870
99CDK180.65706093
100MAP3K50.65634684
101PIM10.64933153
102CAMK2A0.64082340
103STK100.63484723
104STK390.62428204
105PAK10.60683027
106MATK0.60157802
107CDK150.59824686
108CAMK2D0.58923530
109BLK0.58646551
110CDK11A0.58190347
111TBK10.57835031
112PAK30.57801826
113PIK3CG0.56769629
114FES0.55926083
115ROCK20.55844531
116ZAK0.55626572
117MAP3K30.55554499
118MAPK130.55351776
119IKBKE0.55009756
120PRKCG0.54452861
121WNK40.52551443
122BRSK20.52027840
123INSRR0.50848021
124SCYL20.50149128
125DYRK20.48645671
126PLK30.48507146
127LYN0.48389137
128ADRBK10.47811426
129EPHA40.47121813
130MKNK20.46423540
131ATR0.44738955
132CSNK2A10.44468814
133PNCK0.43123185
134KIT0.42950588
135MAP2K30.42645566
136TGFBR20.42507190
137IRAK10.42443293
138SYK0.42308773
139IRAK40.41610728
140NTRK10.41138825
141PRKCD0.40948947
142CSNK2A20.40433522
143STK40.39975857
144STK240.39767267
145CSNK1A10.39590953
146FLT30.39387998
147UHMK10.38705922
148PRKCQ0.38646034
149ACVR1B0.38124850
150PRKCE0.35390922

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.91791121
2Parkinsons disease_Homo sapiens_hsa050125.28918337
3Proteasome_Homo sapiens_hsa030504.42304716
4Ribosome_Homo sapiens_hsa030103.75066508
5Alzheimers disease_Homo sapiens_hsa050103.67170280
6Huntingtons disease_Homo sapiens_hsa050163.63070275
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.92941023
8Cardiac muscle contraction_Homo sapiens_hsa042602.78186124
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.74354246
10RNA polymerase_Homo sapiens_hsa030202.70926178
11Collecting duct acid secretion_Homo sapiens_hsa049662.38922228
12DNA replication_Homo sapiens_hsa030301.97560473
13Synaptic vesicle cycle_Homo sapiens_hsa047211.93433843
14Pyrimidine metabolism_Homo sapiens_hsa002401.76486357
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74473335
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59335737
17Mismatch repair_Homo sapiens_hsa034301.56183829
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55476975
19Protein export_Homo sapiens_hsa030601.50804550
20Vibrio cholerae infection_Homo sapiens_hsa051101.40481879
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.32108967
22Pyruvate metabolism_Homo sapiens_hsa006201.27627518
23Carbon metabolism_Homo sapiens_hsa012001.25325284
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.22661579
25Nucleotide excision repair_Homo sapiens_hsa034201.21777751
26Selenocompound metabolism_Homo sapiens_hsa004501.20726650
27Graft-versus-host disease_Homo sapiens_hsa053321.19020834
28Sulfur relay system_Homo sapiens_hsa041221.16933911
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16367974
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12087717
31Fanconi anemia pathway_Homo sapiens_hsa034601.11575603
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11295828
33Nicotine addiction_Homo sapiens_hsa050331.10724691
34Allograft rejection_Homo sapiens_hsa053301.09030916
35Purine metabolism_Homo sapiens_hsa002301.07928350
36Type I diabetes mellitus_Homo sapiens_hsa049401.06969388
37Tryptophan metabolism_Homo sapiens_hsa003801.06623807
38Fatty acid elongation_Homo sapiens_hsa000621.04863278
39Nitrogen metabolism_Homo sapiens_hsa009101.02667349
40Primary immunodeficiency_Homo sapiens_hsa053401.01730830
41Asthma_Homo sapiens_hsa053101.01697927
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98756594
43Spliceosome_Homo sapiens_hsa030400.97028687
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96878626
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95486997
46Base excision repair_Homo sapiens_hsa034100.93487882
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.91743780
48Lysosome_Homo sapiens_hsa041420.90606250
49Phototransduction_Homo sapiens_hsa047440.90120545
50Autoimmune thyroid disease_Homo sapiens_hsa053200.88641998
51Homologous recombination_Homo sapiens_hsa034400.88382079
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87271135
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86804191
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85055362
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84945622
56Rheumatoid arthritis_Homo sapiens_hsa053230.83492712
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83035195
58Biosynthesis of amino acids_Homo sapiens_hsa012300.82303140
59Metabolic pathways_Homo sapiens_hsa011000.81619139
60Glutathione metabolism_Homo sapiens_hsa004800.81456149
61Propanoate metabolism_Homo sapiens_hsa006400.80760314
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77883277
63Steroid biosynthesis_Homo sapiens_hsa001000.74433959
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.73948404
65RNA transport_Homo sapiens_hsa030130.73905612
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73241376
67Antigen processing and presentation_Homo sapiens_hsa046120.70548441
68Phenylalanine metabolism_Homo sapiens_hsa003600.69509515
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.68437442
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68306803
71Pentose phosphate pathway_Homo sapiens_hsa000300.66899105
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66804124
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65543271
74Fructose and mannose metabolism_Homo sapiens_hsa000510.65374851
75Legionellosis_Homo sapiens_hsa051340.63603370
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63305746
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61718020
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60396006
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60001001
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59890500
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.58820279
82Basal transcription factors_Homo sapiens_hsa030220.58661296
83Caffeine metabolism_Homo sapiens_hsa002320.58624803
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.57258306
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55193946
86Tyrosine metabolism_Homo sapiens_hsa003500.54440026
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.54248890
88Serotonergic synapse_Homo sapiens_hsa047260.53734873
89Fatty acid metabolism_Homo sapiens_hsa012120.53226700
90N-Glycan biosynthesis_Homo sapiens_hsa005100.52143004
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.51382898
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50711229
93GABAergic synapse_Homo sapiens_hsa047270.49887723
94Phagosome_Homo sapiens_hsa041450.49682535
95Sphingolipid metabolism_Homo sapiens_hsa006000.49076983
96Regulation of autophagy_Homo sapiens_hsa041400.47688145
97Linoleic acid metabolism_Homo sapiens_hsa005910.46854424
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46137004
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45927869
100Fatty acid degradation_Homo sapiens_hsa000710.45018413
101RNA degradation_Homo sapiens_hsa030180.44224118
102Hematopoietic cell lineage_Homo sapiens_hsa046400.43333068
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42793614
104Morphine addiction_Homo sapiens_hsa050320.42193008
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40299115
106Dopaminergic synapse_Homo sapiens_hsa047280.38722575
107Peroxisome_Homo sapiens_hsa041460.37800193
108Vitamin B6 metabolism_Homo sapiens_hsa007500.35400792
109Folate biosynthesis_Homo sapiens_hsa007900.35303541
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34884921
111Amphetamine addiction_Homo sapiens_hsa050310.34455929
112Epstein-Barr virus infection_Homo sapiens_hsa051690.33419834
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33035147
114Olfactory transduction_Homo sapiens_hsa047400.32919408
115Galactose metabolism_Homo sapiens_hsa000520.30551041
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29326683
117Sulfur metabolism_Homo sapiens_hsa009200.28520003
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28024980
119Long-term potentiation_Homo sapiens_hsa047200.27741035
120Taste transduction_Homo sapiens_hsa047420.27091078
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25047547
122Oocyte meiosis_Homo sapiens_hsa041140.23239032
123Circadian entrainment_Homo sapiens_hsa047130.20510734
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.19481206
125Arginine and proline metabolism_Homo sapiens_hsa003300.19362354
126Calcium signaling pathway_Homo sapiens_hsa040200.18702478
127Arachidonic acid metabolism_Homo sapiens_hsa005900.18065996
128Thyroid cancer_Homo sapiens_hsa052160.15081225
129Alcoholism_Homo sapiens_hsa050340.13889078
130Chemical carcinogenesis_Homo sapiens_hsa052040.11571733
131Butanoate metabolism_Homo sapiens_hsa006500.10503181
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10394245
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10291700
134Glutamatergic synapse_Homo sapiens_hsa047240.09277732
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.09186236
136One carbon pool by folate_Homo sapiens_hsa006700.09037188
137Non-homologous end-joining_Homo sapiens_hsa034500.08583881
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.08368280

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