SMIM10L2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)8.14740323
2synaptic vesicle docking involved in exocytosis (GO:0016081)8.13250424
3glutamate secretion (GO:0014047)7.54912133
4regulation of short-term neuronal synaptic plasticity (GO:0048172)7.10823158
5synaptic vesicle exocytosis (GO:0016079)6.57273926
6regulation of synaptic vesicle exocytosis (GO:2000300)6.38580873
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.75535446
8regulation of synaptic vesicle transport (GO:1902803)5.73669019
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.49515448
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.46552230
11cellular potassium ion homeostasis (GO:0030007)5.45152652
12neurotransmitter secretion (GO:0007269)5.29239664
13regulation of neuronal synaptic plasticity (GO:0048168)5.17910786
14locomotory exploration behavior (GO:0035641)5.07154724
15sodium ion export (GO:0071436)4.98855459
16exploration behavior (GO:0035640)4.82717748
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.79440622
18vocalization behavior (GO:0071625)4.70050933
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.58819176
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53673299
21regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.47282207
22L-amino acid import (GO:0043092)4.42993120
23positive regulation of synapse maturation (GO:0090129)4.37796409
24neurotransmitter transport (GO:0006836)4.30142324
25protein localization to synapse (GO:0035418)4.26409037
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.25597310
27neuronal action potential propagation (GO:0019227)4.23671940
28synaptic transmission, glutamatergic (GO:0035249)4.19207070
29cerebellar granule cell differentiation (GO:0021707)4.18725118
30negative regulation of synaptic transmission, GABAergic (GO:0032229)4.16051041
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.16038812
32positive regulation of dendritic spine morphogenesis (GO:0061003)4.11516164
33regulation of synapse structural plasticity (GO:0051823)4.10507573
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.08567204
35positive regulation of dendritic spine development (GO:0060999)4.06544532
36regulation of glutamate receptor signaling pathway (GO:1900449)4.06118844
37dendritic spine morphogenesis (GO:0060997)4.03583640
38regulation of neurotransmitter secretion (GO:0046928)4.02756638
39mating behavior (GO:0007617)4.00157701
40amino acid import (GO:0043090)3.96041928
41central nervous system myelination (GO:0022010)3.92892614
42axon ensheathment in central nervous system (GO:0032291)3.92892614
43neuron-neuron synaptic transmission (GO:0007270)3.88425640
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.87465484
45neuronal ion channel clustering (GO:0045161)3.87172639
46regulation of voltage-gated calcium channel activity (GO:1901385)3.86874444
47regulation of neurotransmitter levels (GO:0001505)3.86017697
48regulation of synaptic plasticity (GO:0048167)3.85081577
49positive regulation of membrane potential (GO:0045838)3.82280918
50neuromuscular process controlling balance (GO:0050885)3.81650305
51neuron cell-cell adhesion (GO:0007158)3.81385357
52synaptic vesicle endocytosis (GO:0048488)3.81056295
53cell communication by electrical coupling (GO:0010644)3.78682230
54potassium ion import (GO:0010107)3.75615368
55postsynaptic membrane organization (GO:0001941)3.75398386
56layer formation in cerebral cortex (GO:0021819)3.74792645
57potassium ion homeostasis (GO:0055075)3.72376152
58negative regulation of dendrite morphogenesis (GO:0050774)3.69003756
59positive regulation of neurotransmitter transport (GO:0051590)3.64522136
60regulation of postsynaptic membrane potential (GO:0060078)3.64271146
61glutamate receptor signaling pathway (GO:0007215)3.64013560
62regulation of dendritic spine morphogenesis (GO:0061001)3.63889259
63neurotransmitter-gated ion channel clustering (GO:0072578)3.63577999
64regulation of neurotransmitter transport (GO:0051588)3.63171424
65regulation of synapse maturation (GO:0090128)3.55157719
66positive regulation of neurotransmitter secretion (GO:0001956)3.53350463
67regulation of vesicle fusion (GO:0031338)3.50829196
68cerebellar Purkinje cell differentiation (GO:0021702)3.48151897
69long-term memory (GO:0007616)3.37023405
70cellular sodium ion homeostasis (GO:0006883)3.36768552
71regulation of dendritic spine development (GO:0060998)3.33898661
72gamma-aminobutyric acid signaling pathway (GO:0007214)3.32305866
73cell migration in hindbrain (GO:0021535)3.31772243
74dendritic spine organization (GO:0097061)3.31645483
75response to insecticide (GO:0017085)3.30480830
76membrane depolarization during action potential (GO:0086010)3.29529945
77membrane depolarization (GO:0051899)3.24634963
78gamma-aminobutyric acid transport (GO:0015812)3.24179544
79regulation of ARF protein signal transduction (GO:0032012)3.21811063
80G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.17082715
81neuromuscular synaptic transmission (GO:0007274)3.15429309
82regulation of synaptic transmission (GO:0050804)3.11882014
83proline transport (GO:0015824)3.11279392
84activation of protein kinase A activity (GO:0034199)3.07598801
85transmission of nerve impulse (GO:0019226)3.06607639
86cytoskeletal anchoring at plasma membrane (GO:0007016)3.04859086
87establishment of synaptic vesicle localization (GO:0097480)3.04673682
88synaptic vesicle transport (GO:0048489)3.04673682
89cell communication involved in cardiac conduction (GO:0086065)3.04099950
90social behavior (GO:0035176)3.02836640
91intraspecies interaction between organisms (GO:0051703)3.02836640
92acidic amino acid transport (GO:0015800)3.01295540
93synaptic transmission (GO:0007268)3.01270184
94positive regulation of dendrite development (GO:1900006)2.98722606
95neuromuscular process (GO:0050905)2.96210615
96neuromuscular process controlling posture (GO:0050884)2.95954954
97regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.94594659
98chemosensory behavior (GO:0007635)2.93676454
99presynaptic membrane organization (GO:0097090)2.93273319
100behavioral response to cocaine (GO:0048148)2.90772314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50029257
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.91070358
3REST_21632747_ChIP-Seq_MESCs_Mouse3.18827897
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18525966
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17344231
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11938595
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.99089764
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89982188
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89982188
10DROSHA_22980978_ChIP-Seq_HELA_Human2.89188267
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.83550744
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.78270662
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.77536557
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.72243534
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.69820993
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.67868579
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.61834683
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.59948917
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.56532230
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54796957
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.53322274
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53230419
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.41894571
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.37964410
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33246933
26GBX2_23144817_ChIP-Seq_PC3_Human2.33030792
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.27770809
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.16585269
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12895248
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96882669
31RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.85674753
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.83213510
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.78634814
34KDM2B_26808549_Chip-Seq_K562_Human1.69858783
35AR_21572438_ChIP-Seq_LNCaP_Human1.55226395
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53998641
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.51560104
38CTCF_27219007_Chip-Seq_Bcells_Human1.44876615
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43606317
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33678319
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32638234
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30558667
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29142845
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28872148
45TET1_21490601_ChIP-Seq_MESCs_Mouse1.27301063
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26412217
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23730918
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.23435496
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.21901600
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21250645
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20768112
52OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18461863
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.18172816
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15687746
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15243163
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14526966
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11495820
58AR_19668381_ChIP-Seq_PC3_Human1.10171971
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08824210
60RNF2_27304074_Chip-Seq_NSC_Mouse1.08624322
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06859095
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.04446171
63MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01149226
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99103389
65SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98562991
66YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98391604
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97841231
68ESR2_21235772_ChIP-Seq_MCF-7_Human0.94526020
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94087003
70SOX2_21211035_ChIP-Seq_LN229_Gbm0.93312130
71CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92429476
72BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91699119
73OCT4_19829295_ChIP-Seq_ESCs_Human0.91591835
74LXR_22292898_ChIP-Seq_THP-1_Human0.91183890
75SMAD4_21799915_ChIP-Seq_A2780_Human0.90469339
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89022026
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89022026
78SMC4_20622854_ChIP-Seq_HELA_Human0.88573060
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86884046
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86503905
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85944847
82KLF4_19829295_ChIP-Seq_ESCs_Human0.82597594
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82161388
84KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81884247
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81296791
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79725549
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79615961
88P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79517398
89SMAD3_21741376_ChIP-Seq_EPCs_Human0.79453734
90DPY_21335234_ChIP-Seq_ESCs_Mouse0.79409393
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78932327
92EP300_21415370_ChIP-Seq_HL-1_Mouse0.76462397
93CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76264937
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73738880
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.73597715
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73479891
97CREB1_26743006_Chip-Seq_LNCaP_Human0.71741984
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.71535276
99SOX9_26525672_Chip-Seq_HEART_Mouse0.71282255
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.70429179

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.93992903
2MP0003880_abnormal_central_pattern5.21742879
3MP0004270_analgesia4.29410291
4MP0003635_abnormal_synaptic_transmissio4.10006203
5MP0005423_abnormal_somatic_nervous3.68861074
6MP0002064_seizures3.57771971
7MP0009745_abnormal_behavioral_response3.28199205
8MP0002063_abnormal_learning/memory/cond3.25240083
9MP0009046_muscle_twitch2.92708750
10MP0002272_abnormal_nervous_system2.91296636
11MP0002734_abnormal_mechanical_nocicepti2.81872040
12MP0001486_abnormal_startle_reflex2.81172265
13MP0002572_abnormal_emotion/affect_behav2.72141703
14MP0001968_abnormal_touch/_nociception2.70805373
15MP0003329_amyloid_beta_deposits2.28177875
16MP0003879_abnormal_hair_cell2.26853937
17MP0001501_abnormal_sleep_pattern2.23729395
18MP0008569_lethality_at_weaning2.10877461
19MP0002736_abnormal_nociception_after1.97097730
20MP0002735_abnormal_chemical_nociception1.96814339
21MP0003122_maternal_imprinting1.92444916
22MP0001970_abnormal_pain_threshold1.86147914
23MP0003787_abnormal_imprinting1.82891812
24MP0004811_abnormal_neuron_physiology1.81039748
25MP0003123_paternal_imprinting1.69908697
26MP0002733_abnormal_thermal_nociception1.69100389
27MP0004885_abnormal_endolymph1.67235452
28MP0002067_abnormal_sensory_capabilities1.65271788
29MP0000778_abnormal_nervous_system1.64883702
30MP0001905_abnormal_dopamine_level1.63621307
31MP0002557_abnormal_social/conspecific_i1.61453108
32MP0001440_abnormal_grooming_behavior1.60808855
33MP0009780_abnormal_chondrocyte_physiolo1.58527161
34MP0006276_abnormal_autonomic_nervous1.54134359
35MP0001177_atelectasis1.53489072
36MP0003633_abnormal_nervous_system1.53371143
37MP0001984_abnormal_olfaction1.49799262
38MP0002066_abnormal_motor_capabilities/c1.48280384
39MP0005646_abnormal_pituitary_gland1.46123601
40MP0000955_abnormal_spinal_cord1.43837685
41MP0002882_abnormal_neuron_morphology1.43295494
42MP0000920_abnormal_myelination1.37612541
43MP0003631_nervous_system_phenotype1.36870510
44MP0001502_abnormal_circadian_rhythm1.35115078
45MP0002822_catalepsy1.34100218
46MP0003690_abnormal_glial_cell1.33552849
47MP0005386_behavior/neurological_phenoty1.32267424
48MP0004924_abnormal_behavior1.32267424
49MP0002184_abnormal_innervation1.27850116
50MP0004742_abnormal_vestibular_system1.21140076
51MP0002152_abnormal_brain_morphology1.14000452
52MP0005623_abnormal_meninges_morphology1.09550399
53MP0003632_abnormal_nervous_system1.05228927
54MP0003634_abnormal_glial_cell1.03796191
55MP0002229_neurodegeneration1.00775057
56MP0001963_abnormal_hearing_physiology0.99852573
57MP0000604_amyloidosis0.96063283
58MP0002638_abnormal_pupillary_reflex0.92574663
59MP0003121_genomic_imprinting0.88095847
60MP0001188_hyperpigmentation0.87264793
61MP0001529_abnormal_vocalization0.85926808
62MP0001485_abnormal_pinna_reflex0.84942077
63MP0000566_synostosis0.84109499
64MP0001346_abnormal_lacrimal_gland0.81732783
65MP0002909_abnormal_adrenal_gland0.81361878
66MP0005551_abnormal_eye_electrophysiolog0.80189573
67MP0008874_decreased_physiological_sensi0.80107698
68MP0008877_abnormal_DNA_methylation0.77955095
69MP0002069_abnormal_eating/drinking_beha0.75798442
70MP0002752_abnormal_somatic_nervous0.74952944
71MP0001299_abnormal_eye_distance/0.72749738
72MP0003938_abnormal_ear_development0.70654058
73MP0003075_altered_response_to0.68731014
74MP0003283_abnormal_digestive_organ0.67967830
75MP0000751_myopathy0.67768424
76MP0000639_abnormal_adrenal_gland0.67527452
77MP0001986_abnormal_taste_sensitivity0.67300847
78MP0004142_abnormal_muscle_tone0.64338185
79MP0000579_abnormal_nail_morphology0.63429530
80MP0010386_abnormal_urinary_bladder0.63392381
81MP0003861_abnormal_nervous_system0.63240109
82MP0004085_abnormal_heartbeat0.61879100
83MP0000026_abnormal_inner_ear0.61357953
84MP0002090_abnormal_vision0.60678793
85MP0010769_abnormal_survival0.59855324
86MP0005499_abnormal_olfactory_system0.58674792
87MP0005394_taste/olfaction_phenotype0.58674792
88MP0003137_abnormal_impulse_conducting0.57906999
89MP0005535_abnormal_body_temperature0.57544825
90MP0005167_abnormal_blood-brain_barrier0.57011138
91MP0010768_mortality/aging0.56759759
92MP0002249_abnormal_larynx_morphology0.56513442
93MP0010770_preweaning_lethality0.55760926
94MP0002082_postnatal_lethality0.55760926
95MP0000631_abnormal_neuroendocrine_gland0.54718008
96MP0008872_abnormal_physiological_respon0.54152013
97MP0004130_abnormal_muscle_cell0.53610139
98MP0005187_abnormal_penis_morphology0.52662181
99MP0001943_abnormal_respiration0.51313381
100MP0003956_abnormal_body_size0.48942523

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.60119425
2Focal motor seizures (HP:0011153)7.14914366
3Focal seizures (HP:0007359)6.14841264
4Action tremor (HP:0002345)5.35965279
5Febrile seizures (HP:0002373)5.20679376
6Epileptic encephalopathy (HP:0200134)5.16448120
7Atonic seizures (HP:0010819)5.07310151
8Limb dystonia (HP:0002451)4.98535593
9Supranuclear gaze palsy (HP:0000605)4.82864956
10Abnormality of binocular vision (HP:0011514)4.29042792
11Diplopia (HP:0000651)4.29042792
12Ankle clonus (HP:0011448)4.20236980
13Generalized tonic-clonic seizures (HP:0002069)4.04315048
14Neurofibrillary tangles (HP:0002185)3.95845240
15Visual hallucinations (HP:0002367)3.83480546
16Postural instability (HP:0002172)3.83103373
17Abnormal eating behavior (HP:0100738)3.75946105
18Torticollis (HP:0000473)3.60382255
19Progressive cerebellar ataxia (HP:0002073)3.58727074
20Spastic gait (HP:0002064)3.49047152
21Absence seizures (HP:0002121)3.47166474
22Urinary bladder sphincter dysfunction (HP:0002839)3.36099420
23Dialeptic seizures (HP:0011146)3.31725340
24Papilledema (HP:0001085)3.31144055
25Urinary urgency (HP:0000012)3.30210512
26Dysmetria (HP:0001310)3.26417910
27Cerebral inclusion bodies (HP:0100314)3.25667361
28Impaired vibration sensation in the lower limbs (HP:0002166)3.22798371
29Mutism (HP:0002300)3.17574441
30Annular pancreas (HP:0001734)3.15259070
31Depression (HP:0000716)3.14274383
32Bradykinesia (HP:0002067)3.11535647
33Truncal ataxia (HP:0002078)3.05400726
34Focal dystonia (HP:0004373)3.04747439
35Cerebral hypomyelination (HP:0006808)3.03744549
36Anxiety (HP:0000739)2.95848894
37Obstructive sleep apnea (HP:0002870)2.90165970
38Epileptiform EEG discharges (HP:0011182)2.87991486
39Akinesia (HP:0002304)2.84437730
40Craniofacial dystonia (HP:0012179)2.80995217
41Poor eye contact (HP:0000817)2.80658597
42Intention tremor (HP:0002080)2.78756798
43Tetraplegia (HP:0002445)2.77173765
44Delusions (HP:0000746)2.69605110
45Status epilepticus (HP:0002133)2.69226936
46Hemiplegia (HP:0002301)2.65078652
47Abnormality of the corticospinal tract (HP:0002492)2.56640444
48Sleep apnea (HP:0010535)2.52159094
49EEG with generalized epileptiform discharges (HP:0011198)2.52080560
50Abnormal social behavior (HP:0012433)2.51622769
51Impaired social interactions (HP:0000735)2.51622769
52Rigidity (HP:0002063)2.51573010
53Polyphagia (HP:0002591)2.51316401
54Neuronal loss in central nervous system (HP:0002529)2.46717984
55Aplasia involving bones of the upper limbs (HP:0009823)2.46098518
56Aplasia of the phalanges of the hand (HP:0009802)2.46098518
57Aplasia involving bones of the extremities (HP:0009825)2.46098518
58Dysdiadochokinesis (HP:0002075)2.45371515
59Apathy (HP:0000741)2.43481268
60Amblyopia (HP:0000646)2.40118020
61Lower limb muscle weakness (HP:0007340)2.39081501
62Ventricular fibrillation (HP:0001663)2.38388047
63Hypsarrhythmia (HP:0002521)2.34168539
64Clonus (HP:0002169)2.33915271
65Abnormality of the lower motor neuron (HP:0002366)2.20472926
66Insomnia (HP:0100785)2.17961274
67Diminished motivation (HP:0000745)2.17942824
68Stereotypic behavior (HP:0000733)2.17861470
69Spastic tetraparesis (HP:0001285)2.17800982
70Hemiparesis (HP:0001269)2.15934401
71Morphological abnormality of the pyramidal tract (HP:0002062)2.13529158
72Peripheral hypomyelination (HP:0007182)2.11691892
73Bronchomalacia (HP:0002780)2.10672776
74Drooling (HP:0002307)2.08475117
75Impaired vibratory sensation (HP:0002495)2.06868148
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02194729
77Impaired smooth pursuit (HP:0007772)2.01643312
78Incomplete penetrance (HP:0003829)2.01445565
79Turricephaly (HP:0000262)1.99931207
80Broad-based gait (HP:0002136)1.99127656
81CNS hypomyelination (HP:0003429)1.97466575
82Megalencephaly (HP:0001355)1.95753488
83Degeneration of the lateral corticospinal tracts (HP:0002314)1.95748507
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95748507
85Resting tremor (HP:0002322)1.92905469
86Choreoathetosis (HP:0001266)1.90125558
87Excessive salivation (HP:0003781)1.88829023
88Split foot (HP:0001839)1.87529196
89Fetal akinesia sequence (HP:0001989)1.87428019
90Rapidly progressive (HP:0003678)1.87372856
91Lower limb amyotrophy (HP:0007210)1.82336116
92Bundle branch block (HP:0011710)1.80205113
93Prolonged QT interval (HP:0001657)1.76102674
94Lower limb asymmetry (HP:0100559)1.75711906
95Increased circulating renin level (HP:0000848)1.75564754
96Syncope (HP:0001279)1.73832199
97Diminished movement (HP:0002374)1.73457221
98Unsteady gait (HP:0002317)1.72973076
99Abnormality of ocular smooth pursuit (HP:0000617)1.72280595
100Abnormal EKG (HP:0003115)1.71482831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.89825610
2PAK63.80236644
3NTRK33.72849003
4MARK13.52807768
5DAPK23.46551238
6MAP3K93.05565577
7PINK12.84375545
8NTRK22.62977919
9PRKD32.54309759
10LATS22.33092796
11MINK12.32759485
12UHMK12.23198141
13NTRK12.15387755
14CAMKK12.13975940
15CASK2.07732084
16ARAF1.83601487
17GRK51.70128977
18CDK51.67567422
19PLK21.57498087
20CDK191.56738949
21CAMK11.51614018
22SGK4941.37242478
23SGK2231.37242478
24DAPK11.32773543
25KSR21.32714210
26PHKG11.31368993
27PHKG21.31368993
28PRKCG1.30088722
29TYRO31.30064971
30CAMK2B1.26763226
31CDK151.25976610
32MAPK131.23327433
33CDK181.20846053
34CDK141.20740708
35CDK11A1.15303272
36PRPF4B1.12156563
37RIPK11.06565148
38SIK21.00829384
39MAPK120.99670222
40PRKCH0.99482831
41PAK30.98398846
42CAMK2A0.95600042
43MARK20.93431256
44STK110.92976859
45RIPK40.92942223
46DYRK1A0.91311057
47MAPKAPK50.90974302
48PNCK0.89781219
49BRSK10.88459106
50PKN10.88124564
51SGK20.85918405
52ALK0.82082318
53STK380.81583161
54CAMK2G0.80669716
55OXSR10.77501017
56MAP3K130.76079211
57CAMKK20.73761820
58FGFR20.73169605
59DAPK30.72979113
60NEK60.72780222
61MAP2K70.72322206
62SGK30.68638320
63TNIK0.67075229
64CSNK1G20.66343769
65SGK10.66236965
66CAMK40.64852700
67MAP3K110.62608468
68PDK10.59103984
69MAP3K40.58873034
70MAP3K120.58157050
71KSR10.57353797
72PRKG20.56834701
73MAPK100.55693173
74CAMK1G0.54908732
75RPS6KA30.53331422
76MAP2K40.52949013
77PDPK10.52781311
78BRAF0.51349403
79CAMK2D0.50938621
80PRKCZ0.47219295
81ICK0.44797785
82RET0.44118960
83ROCK20.42449164
84DYRK20.42114781
85MAP3K10.38553048
86RAF10.36872545
87ROCK10.35784657
88CAMK1D0.34930141
89LIMK10.34658302
90MOS0.31888729
91CSNK1E0.28972162
92PRKCA0.28585968
93FES0.28449861
94WNK10.27912746
95FYN0.27468093
96MAP3K20.27431754
97LMTK20.26696075
98CSNK1G30.25530995
99IRAK20.24603948
100RPS6KB10.23991794

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.09040153
2Synaptic vesicle cycle_Homo sapiens_hsa047214.01482303
3Amphetamine addiction_Homo sapiens_hsa050312.94680580
4Long-term potentiation_Homo sapiens_hsa047202.80283628
5Circadian entrainment_Homo sapiens_hsa047132.65402333
6GABAergic synapse_Homo sapiens_hsa047272.63719567
7Glutamatergic synapse_Homo sapiens_hsa047242.47118344
8Morphine addiction_Homo sapiens_hsa050322.46288444
9Insulin secretion_Homo sapiens_hsa049112.43254047
10Cocaine addiction_Homo sapiens_hsa050302.34065323
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32558569
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32018493
13Aldosterone synthesis and secretion_Homo sapiens_hsa049252.24926712
14Dopaminergic synapse_Homo sapiens_hsa047282.19561898
15Gastric acid secretion_Homo sapiens_hsa049712.10762469
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99868472
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.86414582
18Cholinergic synapse_Homo sapiens_hsa047251.84179183
19Vitamin B6 metabolism_Homo sapiens_hsa007501.83780103
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79169510
21Salivary secretion_Homo sapiens_hsa049701.69276737
22Oxytocin signaling pathway_Homo sapiens_hsa049211.64637953
23Calcium signaling pathway_Homo sapiens_hsa040201.49922409
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48976606
25cAMP signaling pathway_Homo sapiens_hsa040241.45633670
26Renin secretion_Homo sapiens_hsa049241.40749076
27Gap junction_Homo sapiens_hsa045401.36787705
28Olfactory transduction_Homo sapiens_hsa047401.35851348
29Taste transduction_Homo sapiens_hsa047421.32126371
30Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.29482946
31Cardiac muscle contraction_Homo sapiens_hsa042601.24171584
32GnRH signaling pathway_Homo sapiens_hsa049121.20998188
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20887568
34Melanogenesis_Homo sapiens_hsa049161.16269696
35Estrogen signaling pathway_Homo sapiens_hsa049151.15732706
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10107439
37Long-term depression_Homo sapiens_hsa047301.09866188
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09215837
39Glioma_Homo sapiens_hsa052141.08947289
40Collecting duct acid secretion_Homo sapiens_hsa049661.05580222
41Serotonergic synapse_Homo sapiens_hsa047261.04607357
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00315611
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98898666
44Oocyte meiosis_Homo sapiens_hsa041140.95828670
45Bile secretion_Homo sapiens_hsa049760.91589265
46Axon guidance_Homo sapiens_hsa043600.90718676
47Pancreatic secretion_Homo sapiens_hsa049720.88476717
48ErbB signaling pathway_Homo sapiens_hsa040120.83932156
49Thyroid hormone synthesis_Homo sapiens_hsa049180.83099978
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.80576540
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77755858
52Prion diseases_Homo sapiens_hsa050200.75042569
53Dilated cardiomyopathy_Homo sapiens_hsa054140.72912862
54Vibrio cholerae infection_Homo sapiens_hsa051100.72620408
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68757329
56Glucagon signaling pathway_Homo sapiens_hsa049220.67910759
57Type II diabetes mellitus_Homo sapiens_hsa049300.67313176
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.67261505
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65159946
60Phototransduction_Homo sapiens_hsa047440.64942880
61Arginine biosynthesis_Homo sapiens_hsa002200.62972191
62Alcoholism_Homo sapiens_hsa050340.62107099
63Rap1 signaling pathway_Homo sapiens_hsa040150.61556475
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61111317
65MAPK signaling pathway_Homo sapiens_hsa040100.60260274
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59217943
67Arginine and proline metabolism_Homo sapiens_hsa003300.57523109
68Ras signaling pathway_Homo sapiens_hsa040140.55784458
69Wnt signaling pathway_Homo sapiens_hsa043100.55519300
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.55149838
71Inositol phosphate metabolism_Homo sapiens_hsa005620.53796856
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52914663
73VEGF signaling pathway_Homo sapiens_hsa043700.52715816
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52686047
75Ovarian steroidogenesis_Homo sapiens_hsa049130.52233043
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52158398
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.47387989
78Alzheimers disease_Homo sapiens_hsa050100.46259306
79Tight junction_Homo sapiens_hsa045300.43125940
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42977788
81Hippo signaling pathway_Homo sapiens_hsa043900.42587109
82Choline metabolism in cancer_Homo sapiens_hsa052310.40950139
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39309618
84Hedgehog signaling pathway_Homo sapiens_hsa043400.36385794
85Butanoate metabolism_Homo sapiens_hsa006500.35620681
86Endocytosis_Homo sapiens_hsa041440.35347674
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35273705
88Circadian rhythm_Homo sapiens_hsa047100.34691437
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33889702
90beta-Alanine metabolism_Homo sapiens_hsa004100.33735058
91Histidine metabolism_Homo sapiens_hsa003400.33275493
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32342149
93Dorso-ventral axis formation_Homo sapiens_hsa043200.32069693
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30930800
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30596045
96Fatty acid biosynthesis_Homo sapiens_hsa000610.29546327
97Insulin signaling pathway_Homo sapiens_hsa049100.29241775
98Endometrial cancer_Homo sapiens_hsa052130.27920587
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27260011
100AMPK signaling pathway_Homo sapiens_hsa041520.25680948

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