SMG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.77088413
2negative regulation of cell killing (GO:0031342)4.67494125
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.67494125
4histone H3-K4 trimethylation (GO:0080182)4.55223244
5cytoplasmic mRNA processing body assembly (GO:0033962)4.53566369
6interkinetic nuclear migration (GO:0022027)4.51965716
7cellular response to ethanol (GO:0071361)4.26767663
8regulation of gamma-delta T cell differentiation (GO:0045586)4.12980233
9nuclear pore complex assembly (GO:0051292)3.96142040
10positive thymic T cell selection (GO:0045059)3.92165954
11positive T cell selection (GO:0043368)3.91104205
12negative T cell selection (GO:0043383)3.87086603
13regulation of gamma-delta T cell activation (GO:0046643)3.87033674
14mitotic sister chromatid cohesion (GO:0007064)3.81363469
15pre-miRNA processing (GO:0031054)3.80537808
16histone H3-K4 methylation (GO:0051568)3.77736425
17regulation of pigment cell differentiation (GO:0050932)3.74139924
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.66277174
19negative thymic T cell selection (GO:0045060)3.64732059
20positive regulation of developmental pigmentation (GO:0048087)3.64197354
21positive regulation of granulocyte differentiation (GO:0030854)3.62465782
22histone H3-K36 demethylation (GO:0070544)3.52146497
23T cell selection (GO:0045058)3.45880051
24protein K48-linked deubiquitination (GO:0071108)3.44745578
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.44138255
26regulation of translation, ncRNA-mediated (GO:0045974)3.44138255
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.44138255
28peptidyl-lysine trimethylation (GO:0018023)3.41528315
29hepatocyte apoptotic process (GO:0097284)3.34215416
30lipid translocation (GO:0034204)3.33142984
31phospholipid translocation (GO:0045332)3.33142984
32thymic T cell selection (GO:0045061)3.30225860
33regulation of interleukin-12 biosynthetic process (GO:0045075)3.30147345
34nuclear pore organization (GO:0006999)3.25450526
35regulation of establishment of cell polarity (GO:2000114)3.24215202
36definitive hemopoiesis (GO:0060216)3.23779816
37NLS-bearing protein import into nucleus (GO:0006607)3.20692900
38negative regulation of DNA repair (GO:0045738)3.19859419
39histone lysine methylation (GO:0034968)3.17980904
40negative regulation of histone methylation (GO:0031061)3.17154842
41regulation of RNA export from nucleus (GO:0046831)3.17072879
42positive regulation of histone deacetylation (GO:0031065)3.09031457
43histone H3-K9 demethylation (GO:0033169)3.08599147
44nucleus localization (GO:0051647)3.05135094
45retrograde transport, vesicle recycling within Golgi (GO:0000301)2.95722928
46pore complex assembly (GO:0046931)2.95145223
47peptidyl-lysine dimethylation (GO:0018027)2.94533524
48regulation of protein polyubiquitination (GO:1902914)2.93533282
49regulation of nucleobase-containing compound transport (GO:0032239)2.93078880
50dosage compensation (GO:0007549)2.90854181
51peptidyl-lysine methylation (GO:0018022)2.90601285
52N-terminal protein amino acid acetylation (GO:0006474)2.89828269
53regulation of B cell receptor signaling pathway (GO:0050855)2.89536778
54cerebellar Purkinje cell differentiation (GO:0021702)2.88210754
55B cell receptor signaling pathway (GO:0050853)2.87423774
56protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.83215874
57positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.81683003
58regulation of ARF protein signal transduction (GO:0032012)2.78347648
59positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.78194216
60regulation of necroptotic process (GO:0060544)2.77200835
61stress granule assembly (GO:0034063)2.73383433
62establishment of protein localization to Golgi (GO:0072600)2.72931429
63pericardium development (GO:0060039)2.71364423
64histone H4-K16 acetylation (GO:0043984)2.69658485
65regulation of establishment or maintenance of cell polarity (GO:0032878)2.69538337
66snRNA transcription (GO:0009301)2.68319879
67striated muscle atrophy (GO:0014891)2.67348180
68histone lysine demethylation (GO:0070076)2.64866775
69negative regulation of myotube differentiation (GO:0010832)2.64274435
70response to interleukin-15 (GO:0070672)2.63592267
71protein targeting to vacuole (GO:0006623)2.63426688
72protein targeting to lysosome (GO:0006622)2.63426688
73establishment of protein localization to vacuole (GO:0072666)2.63426688
74protein K11-linked deubiquitination (GO:0035871)2.61388631
75protein targeting to Golgi (GO:0000042)2.61296082
76glucocorticoid receptor signaling pathway (GO:0042921)2.59811020
77histone mRNA catabolic process (GO:0071044)2.59360683
78regulation of MHC class I biosynthetic process (GO:0045343)2.57523590
79activated T cell proliferation (GO:0050798)2.56612444
80embryonic process involved in female pregnancy (GO:0060136)2.55484485
81histone-serine phosphorylation (GO:0035404)2.54951883
82positive regulation of protein import into nucleus, translocation (GO:0033160)2.54100358
83peptidyl-threonine phosphorylation (GO:0018107)2.53850229
84regulation of DNA endoreduplication (GO:0032875)2.53113946
85I-kappaB phosphorylation (GO:0007252)2.52750730
86regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.52430061
87positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.52430061
88histone H3-K9 modification (GO:0061647)2.52051839
89histone H3-K9 methylation (GO:0051567)2.51780260
90interferon-gamma production (GO:0032609)2.51661345
91histone methylation (GO:0016571)2.51573393
92insulin-like growth factor receptor signaling pathway (GO:0048009)2.50321718
93skeletal muscle adaptation (GO:0043501)2.50215605
94antigen processing and presentation of endogenous antigen (GO:0019883)2.48096623
95regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.47747505
96positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.47747505
97regulation of T cell tolerance induction (GO:0002664)2.47186423
98histone demethylation (GO:0016577)2.47024480
99monoubiquitinated protein deubiquitination (GO:0035520)2.46337237
100embryonic camera-type eye morphogenesis (GO:0048596)2.46230397
101regulation of histone H3-K9 methylation (GO:0051570)2.46194377
102positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.45582725
103positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44893570
104negative regulation of B cell proliferation (GO:0030889)2.44354798
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.44315868
106establishment of nucleus localization (GO:0040023)2.44024411
107peptidyl-threonine modification (GO:0018210)2.43679830
108regulation of B cell differentiation (GO:0045577)2.43313909
109positive regulation of mRNA catabolic process (GO:0061014)2.40818125
110B cell proliferation (GO:0042100)2.40415262
111corticosteroid receptor signaling pathway (GO:0031958)2.39171438
112regulation of mRNA catabolic process (GO:0061013)2.38803514
113activation of JUN kinase activity (GO:0007257)2.38360844
114Golgi to endosome transport (GO:0006895)2.35642412
115antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35402507
116antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.35402507
117T cell costimulation (GO:0031295)2.34610019
118positive regulation of DNA-templated transcription, initiation (GO:2000144)2.34321515
119positive regulation of B cell differentiation (GO:0045579)2.33877944
120early endosome to late endosome transport (GO:0045022)2.33124367
121phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.32922634
122regulation of histone H3-K27 methylation (GO:0061085)2.32881359
123protein K63-linked deubiquitination (GO:0070536)2.32822758
124embryonic hemopoiesis (GO:0035162)2.32086944
125locomotory exploration behavior (GO:0035641)2.31224384
126T cell receptor signaling pathway (GO:0050852)2.30491351
127antigen receptor-mediated signaling pathway (GO:0050851)2.29756732
128sodium ion export (GO:0071436)2.28612509
129regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.28354378
130positive regulation of gene expression, epigenetic (GO:0045815)2.28042604
131lymphocyte costimulation (GO:0031294)2.27607735
132regulation of NFAT protein import into nucleus (GO:0051532)2.27356360
133phosphatidylinositol dephosphorylation (GO:0046856)2.26376143
134negative regulation of granulocyte differentiation (GO:0030853)2.25050366
135regulation of histone methylation (GO:0031060)2.21900729
136B cell homeostasis (GO:0001782)2.21713207
137protein demethylation (GO:0006482)2.20206169
138protein dealkylation (GO:0008214)2.20206169
139RNA stabilization (GO:0043489)2.19107357
140mRNA stabilization (GO:0048255)2.19107357
141cellular response to interleukin-15 (GO:0071350)2.18703380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.78360096
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.27899055
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.74798927
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.66153354
5E2F7_22180533_ChIP-Seq_HELA_Human3.28111198
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.89352669
7MYC_22102868_ChIP-Seq_BL_Human2.82991722
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.77595879
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63558498
10RUNX_20019798_ChIP-Seq_JUKART_Human2.58521720
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.58061699
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.49746394
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.45211831
14TCF7_22412390_ChIP-Seq_EML_Mouse2.34740904
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.21659739
16KDM2B_26808549_Chip-Seq_DND41_Human2.05561926
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.00990299
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00390152
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.85812770
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85636784
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82964278
22AR_21572438_ChIP-Seq_LNCaP_Human1.80489983
23* MYB_26560356_Chip-Seq_TH1_Human1.80162138
24* MYB_26560356_Chip-Seq_TH2_Human1.77358083
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77293181
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76094584
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.72775474
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71456603
29MAF_26560356_Chip-Seq_TH1_Human1.70300893
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66737204
31DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.66425882
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66408049
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63114149
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63095080
35* UTX_26944678_Chip-Seq_JUKART_Human1.63018349
36SPI1_23127762_ChIP-Seq_K562_Human1.62981046
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61831500
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61475638
39VDR_21846776_ChIP-Seq_THP-1_Human1.60568097
40GATA1_22025678_ChIP-Seq_K562_Human1.57883792
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55615927
42KDM2B_26808549_Chip-Seq_JURKAT_Human1.55058713
43SCL_19346495_ChIP-Seq_HPC-7_Human1.54378037
44TP53_16413492_ChIP-PET_HCT116_Human1.53610265
45* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51041754
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50775774
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48216133
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46841262
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39105717
50GATA3_27048872_Chip-Seq_THYMUS_Human1.36993753
51DROSHA_22980978_ChIP-Seq_HELA_Human1.36266921
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35598019
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34573714
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34032957
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32407834
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.32107251
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29600471
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28853573
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28066501
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27949099
61PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26827166
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26300159
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26023366
64VDR_24763502_ChIP-Seq_THP-1_Human1.25823725
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24563365
66* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24352959
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23953902
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22637304
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22028404
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19692384
71CIITA_25753668_ChIP-Seq_RAJI_Human1.18894519
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18517893
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17157564
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16041591
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16029926
76KDM2B_26808549_Chip-Seq_K562_Human1.15559173
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11834832
78TCF4_23295773_ChIP-Seq_U87_Human1.10539502
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09268712
80ER_23166858_ChIP-Seq_MCF-7_Human1.08130741
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.08118388
82RXR_22108803_ChIP-Seq_LS180_Human1.07820260
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07067530
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06958947
85PU_27001747_Chip-Seq_BMDM_Mouse1.06772215
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06395451
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.06305282
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05976703
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05565145
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05522840
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04562619
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.04345891
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03832517
94GATA2_19941826_ChIP-Seq_K562_Human1.02697547
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02016856
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00312975
97SMAD4_21799915_ChIP-Seq_A2780_Human1.00302359
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00009822
99* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99556840
100* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99556840
101IRF8_21731497_ChIP-ChIP_J774_Mouse0.99436008
102SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99384418
103* FOXA2_19822575_ChIP-Seq_HepG2_Human0.98845186
104AHR_22903824_ChIP-Seq_MCF-7_Human0.98577235
105VDR_24787735_ChIP-Seq_THP-1_Human0.98480503
106STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97749277
107GBX2_23144817_ChIP-Seq_PC3_Human0.97611649
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97440158
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97037626
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97037626
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.96841446
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.95637514
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95589722
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95231383
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94881204
116* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94742287
117PRDM14_20953172_ChIP-Seq_ESCs_Human0.93930747
118TAF15_26573619_Chip-Seq_HEK293_Human0.93638333
119RUNX1_27514584_Chip-Seq_MCF-7_Human0.93085474
120PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92389056
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.92184319
122TP63_23658742_ChIP-Seq_EP156T_Human0.92098769
123ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90186799
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89935302
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89467066
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.89281714
127FLI1_21867929_ChIP-Seq_TH2_Mouse0.88561164
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88490610
129RARB_27405468_Chip-Seq_BRAIN_Mouse0.88377993
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87823372
131NCOR1_26117541_ChIP-Seq_K562_Human0.87713063
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86425494
133STAT3_23295773_ChIP-Seq_U87_Human0.85683656
134BRD4_25478319_ChIP-Seq_HGPS_Human0.85682119
135GATA1_19941826_ChIP-Seq_K562_Human0.84655458
136MAF_26560356_Chip-Seq_TH2_Human0.83288314
137SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81570233
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81466365
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81145456
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80483698
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.80198252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.56861131
2MP0002166_altered_tumor_susceptibility3.20433148
3MP0003300_gastrointestinal_ulcer3.14687553
4MP0005076_abnormal_cell_differentiation2.64835926
5MP0003763_abnormal_thymus_physiology2.60703390
6MP0003787_abnormal_imprinting2.52426085
7MP0002006_tumorigenesis2.41698751
8MP0004381_abnormal_hair_follicle2.33244203
9MP0010352_gastrointestinal_tract_polyps2.30661548
10MP0001835_abnormal_antigen_presentation2.28691032
11MP0003045_fibrosis2.26283974
12MP0005409_darkened_coat_color2.26071648
13MP0001800_abnormal_humoral_immune2.23175845
14MP0004808_abnormal_hematopoietic_stem2.16826185
15MP0009278_abnormal_bone_marrow2.16767434
16MP0002396_abnormal_hematopoietic_system2.11745094
17MP0010307_abnormal_tumor_latency2.04874304
18MP0001790_abnormal_immune_system2.03289239
19MP0005387_immune_system_phenotype2.03289239
20MP0005671_abnormal_response_to2.02311895
21MP0004510_myositis1.99865318
22MP0003303_peritoneal_inflammation1.99349475
23MP0002009_preneoplasia1.92901627
24MP0000685_abnormal_immune_system1.90375161
25MP0002398_abnormal_bone_marrow1.86247821
26MP0000703_abnormal_thymus_morphology1.85882510
27MP0005174_abnormal_tail_pigmentation1.83959340
28MP0008961_abnormal_basal_metabolism1.82649076
29MP0010234_abnormal_vibrissa_follicle1.77631108
30MP0001873_stomach_inflammation1.74588416
31MP0008057_abnormal_DNA_replication1.73487943
32MP0008877_abnormal_DNA_methylation1.70980912
33MP0003890_abnormal_embryonic-extraembry1.70942443
34MP0002452_abnormal_antigen_presenting1.67604736
35MP0004947_skin_inflammation1.61441574
36MP0002420_abnormal_adaptive_immunity1.57288435
37MP0001819_abnormal_immune_cell1.55385996
38MP0002723_abnormal_immune_serum1.53974950
39MP0003866_abnormal_defecation1.51527810
40MP0003705_abnormal_hypodermis_morpholog1.50928402
41MP0003183_abnormal_peptide_metabolism1.50448642
42MP0003828_pulmonary_edema1.46357509
43MP0000716_abnormal_immune_system1.45919353
44MP0005000_abnormal_immune_tolerance1.40622249
45MP0003091_abnormal_cell_migration1.39844912
46MP0002722_abnormal_immune_system1.33543122
47MP0009115_abnormal_fat_cell1.33205401
48MP0010155_abnormal_intestine_physiology1.33192988
49MP0000689_abnormal_spleen_morphology1.32785449
50MP0000015_abnormal_ear_pigmentation1.31627187
51MP0003656_abnormal_erythrocyte_physiolo1.30125968
52MP0003950_abnormal_plasma_membrane1.30088277
53MP0005397_hematopoietic_system_phenotyp1.28717752
54MP0001545_abnormal_hematopoietic_system1.28717752
55MP0005451_abnormal_body_composition1.28188894
56MP0000371_diluted_coat_color1.25295216
57MP0001851_eye_inflammation1.24788378
58MP0003172_abnormal_lysosome_physiology1.24437323
59MP0004859_abnormal_synaptic_plasticity1.20740729
60MP0002405_respiratory_system_inflammati1.20193700
61MP0003566_abnormal_cell_adhesion1.17286524
62MP0000733_abnormal_muscle_development1.17115954
63MP0008569_lethality_at_weaning1.16620248
64MP0003646_muscle_fatigue1.14291371
65MP0002429_abnormal_blood_cell1.10938841
66MP0000427_abnormal_hair_cycle1.10533281
67MP0001849_ear_inflammation1.09474006
68MP0010094_abnormal_chromosome_stability1.05294474
69MP0003221_abnormal_cardiomyocyte_apopto1.04594764
70MP0002928_abnormal_bile_duct1.00965811
71MP0002877_abnormal_melanocyte_morpholog0.99407385
72MP0003121_genomic_imprinting0.98805499
73MP0003436_decreased_susceptibility_to0.97464816
74MP0003111_abnormal_nucleus_morphology0.92801634
75MP0002095_abnormal_skin_pigmentation0.92613851
76MP0002332_abnormal_exercise_endurance0.92333460
77MP0002086_abnormal_extraembryonic_tissu0.91220185
78MP0008260_abnormal_autophagy0.90299296
79MP0002419_abnormal_innate_immunity0.89815993
80MP0005666_abnormal_adipose_tissue0.89751672
81MP0005464_abnormal_platelet_physiology0.89618074
82MP0009046_muscle_twitch0.88787654
83MP0005621_abnormal_cell_physiology0.86952976
84MP0000350_abnormal_cell_proliferation0.86162510
85MP0009703_decreased_birth_body0.85663232
86MP0004197_abnormal_fetal_growth/weight/0.85366030
87MP0004484_altered_response_of0.83630680
88MP0003984_embryonic_growth_retardation0.83542758
89MP0005025_abnormal_response_to0.82893544
90MP0002925_abnormal_cardiovascular_devel0.82798587
91MP0002088_abnormal_embryonic_growth/wei0.82692322
92MP0009780_abnormal_chondrocyte_physiolo0.81322800
93MP0003868_abnormal_feces_composition0.81188627
94MP0003453_abnormal_keratinocyte_physiol0.79873015
95MP0010678_abnormal_skin_adnexa0.79250687
96MP0004883_abnormal_blood_vessel0.78496324
97MP0001853_heart_inflammation0.78350444
98MP0003077_abnormal_cell_cycle0.78297124
99MP0005075_abnormal_melanosome_morpholog0.77689947
100MP0003690_abnormal_glial_cell0.77367842
101MP0004264_abnormal_extraembryonic_tissu0.74828044
102MP0005380_embryogenesis_phenotype0.73926407
103MP0001672_abnormal_embryogenesis/_devel0.73926407
104MP0004185_abnormal_adipocyte_glucose0.73891692
105MP0002254_reproductive_system_inflammat0.73743503
106MP0002019_abnormal_tumor_incidence0.72739652
107MP0000003_abnormal_adipose_tissue0.72598534
108MP0001915_intracranial_hemorrhage0.71640265
109MP0010630_abnormal_cardiac_muscle0.71097295
110MP0002075_abnormal_coat/hair_pigmentati0.70531826
111MP0001845_abnormal_inflammatory_respons0.69574616
112MP0005266_abnormal_metabolism0.69015054
113MP0005310_abnormal_salivary_gland0.68898656
114MP0003448_altered_tumor_morphology0.68384439
115MP0000465_gastrointestinal_hemorrhage0.68309216
116MP0001784_abnormal_fluid_regulation0.66301765
117MP0008770_decreased_survivor_rate0.65882050
118MP0000383_abnormal_hair_follicle0.65666393
119MP0002998_abnormal_bone_remodeling0.65631111
120MP0004130_abnormal_muscle_cell0.63904947
121MP0002168_other_aberrant_phenotype0.63499292
122MP0005023_abnormal_wound_healing0.63450047
123MP0003943_abnormal_hepatobiliary_system0.62830146

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.75482146
2Macroorchidism (HP:0000053)3.39710105
3T lymphocytopenia (HP:0005403)3.34544949
4Abnormality of T cell number (HP:0011839)3.10932528
5Recurrent viral infections (HP:0004429)3.03845402
6Absent frontal sinuses (HP:0002688)3.01999063
7Volvulus (HP:0002580)3.01108974
8Narrow palate (HP:0000189)2.86491461
9Thyroiditis (HP:0100646)2.78952111
10Panhypogammaglobulinemia (HP:0003139)2.70369985
11Heterotopia (HP:0002282)2.64695016
12Papillary thyroid carcinoma (HP:0002895)2.58429275
13Recurrent fungal infections (HP:0002841)2.56980361
14Protruding tongue (HP:0010808)2.53754175
15Fair hair (HP:0002286)2.52566452
16Cerebral aneurysm (HP:0004944)2.52507399
17Long eyelashes (HP:0000527)2.49531806
18Abnormality of B cell number (HP:0010975)2.48930650
19B lymphocytopenia (HP:0010976)2.48930650
20Dysmetric saccades (HP:0000641)2.46656483
21Colitis (HP:0002583)2.39473514
22Neonatal hypoglycemia (HP:0001998)2.29423287
23Urethral obstruction (HP:0000796)2.29385919
24Autoimmune hemolytic anemia (HP:0001890)2.25379455
25Acute lymphatic leukemia (HP:0006721)2.23457654
26Prominent nose (HP:0000448)2.22083787
27Subacute progressive viral hepatitis (HP:0006572)2.15958361
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.15925660
29Hyperkalemia (HP:0002153)2.15689761
30Generalized hypopigmentation of hair (HP:0011358)2.14746077
31Submucous cleft hard palate (HP:0000176)2.14489614
32Truncal obesity (HP:0001956)2.13878586
33Aortic aneurysm (HP:0004942)2.13838599
34Hyperacusis (HP:0010780)2.12452064
35Genetic anticipation (HP:0003743)2.11113327
36Short 4th metacarpal (HP:0010044)2.11108428
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.11108428
38Lip pit (HP:0100267)2.11065265
39Short chin (HP:0000331)2.09904079
40Impaired smooth pursuit (HP:0007772)2.07648957
41Recurrent cutaneous fungal infections (HP:0011370)2.06956071
42Chronic mucocutaneous candidiasis (HP:0002728)2.06956071
43Abnormality of ocular smooth pursuit (HP:0000617)2.06762533
44Autoimmune thrombocytopenia (HP:0001973)2.06105330
45Agammaglobulinemia (HP:0004432)2.05488328
46Widely spaced teeth (HP:0000687)2.03584918
47Abnormality of the columella (HP:0009929)2.02446938
48Vertebral arch anomaly (HP:0008438)2.02394449
49Obsessive-compulsive behavior (HP:0000722)2.00161856
50Hypoplasia of the thymus (HP:0000778)1.99648289
51Severe combined immunodeficiency (HP:0004430)1.97134113
52Trigonocephaly (HP:0000243)1.96998782
53Progressive cerebellar ataxia (HP:0002073)1.96445678
54Aqueductal stenosis (HP:0002410)1.95836887
55Persistence of primary teeth (HP:0006335)1.95427417
56Inflammation of the large intestine (HP:0002037)1.95421320
57Hematochezia (HP:0002573)1.95223860
58Abnormality of the nasal septum (HP:0000419)1.94991692
59Recurrent bronchitis (HP:0002837)1.94529328
60Broad face (HP:0000283)1.91964797
61Acute myeloid leukemia (HP:0004808)1.90935054
62Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90931171
63Anal stenosis (HP:0002025)1.90185842
64Chromsome breakage (HP:0040012)1.89763234
65Clumsiness (HP:0002312)1.87840427
66Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87813676
67Gastrointestinal inflammation (HP:0004386)1.87471185
68IgA deficiency (HP:0002720)1.85140679
69Blue irides (HP:0000635)1.84983782
70Viral hepatitis (HP:0006562)1.84315472
71Hemiplegia (HP:0002301)1.84206508
72Abnormality of incisor morphology (HP:0011063)1.83835043
73Limited elbow extension (HP:0001377)1.83768475
74Slow saccadic eye movements (HP:0000514)1.81981946
75Abnormality of T cells (HP:0002843)1.81611968
76Sparse lateral eyebrow (HP:0005338)1.80584207
77Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79821111
78Abnormality of the epiphyses of the hand (HP:0005924)1.78076719
79Urinary bladder sphincter dysfunction (HP:0002839)1.78018544
80Syringomyelia (HP:0003396)1.77885642
81Spinal cord lesions (HP:0100561)1.77885642
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77558918
83Pointed chin (HP:0000307)1.77496686
84Abnormality of the lower motor neuron (HP:0002366)1.77378216
85Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.76767214
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76696301
87Chronic diarrhea (HP:0002028)1.76439195
88Abnormality of the distal phalanx of the thumb (HP:0009617)1.76046642
89Overgrowth (HP:0001548)1.74542738
90Periodontitis (HP:0000704)1.73533767
91Combined immunodeficiency (HP:0005387)1.73141221
92Broad palm (HP:0001169)1.73050423
93Eczematoid dermatitis (HP:0000976)1.72890806
94Frequent falls (HP:0002359)1.72617581
95Spontaneous hematomas (HP:0007420)1.72566468
96Gastrointestinal stroma tumor (HP:0100723)1.71048120
97Arterial thrombosis (HP:0004420)1.70904560
98Dislocated radial head (HP:0003083)1.70896657
99Low anterior hairline (HP:0000294)1.70744197
100Acanthocytosis (HP:0001927)1.70438295
101Deep philtrum (HP:0002002)1.70131609
102Astrocytoma (HP:0009592)1.70040536
103Abnormality of the astrocytes (HP:0100707)1.70040536
104Eosinophilia (HP:0001880)1.69705458
105Transitional cell carcinoma of the bladder (HP:0006740)1.69566759
106Elfin facies (HP:0004428)1.69478499
107Thick eyebrow (HP:0000574)1.69114318
108Sandal gap (HP:0001852)1.69079473
109Inappropriate behavior (HP:0000719)1.68523177
110Coarse hair (HP:0002208)1.68393008
111Abnormality of the left ventricular outflow tract (HP:0011103)1.67201757
112Subaortic stenosis (HP:0001682)1.67201757
113Mitral valve prolapse (HP:0001634)1.66336856
114Hypoplastic iliac wings (HP:0002866)1.65831440
115Action tremor (HP:0002345)1.65773332
116Cubitus valgus (HP:0002967)1.65322229
117Shallow orbits (HP:0000586)1.64465450
118Increased density of long bones (HP:0006392)1.64422900
119Hyperventilation (HP:0002883)1.63946688
120Curly hair (HP:0002212)1.63771063
121Gaze-evoked nystagmus (HP:0000640)1.63215616
122Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.62245840
123Clubbing of toes (HP:0100760)1.62185679
124Optic neuritis (HP:0100653)1.61810350
125Retrobulbar optic neuritis (HP:0100654)1.61810350
126Flat acetabular roof (HP:0003180)1.61689633
127Ectopic kidney (HP:0000086)1.61247931
128Lymphopenia (HP:0001888)1.61121587
129Cystic hygroma (HP:0000476)1.60902139
130Renovascular hypertension (HP:0100817)1.60617756
131Depressed nasal tip (HP:0000437)1.60566466
132Papilloma (HP:0012740)1.58544377
133Verrucae (HP:0200043)1.58544377
134Hypoplastic labia majora (HP:0000059)1.58359223
135Cellulitis (HP:0100658)1.58030597
136Abnormality of the radial head (HP:0003995)1.57959518
137IgM deficiency (HP:0002850)1.57564978
138Conjunctival telangiectasia (HP:0000524)1.57331506
139Abnormality of the frontal sinuses (HP:0002687)1.56805617
140Abnormality of chromosome segregation (HP:0002916)1.56739607
141Relative macrocephaly (HP:0004482)1.56396413
142Germ cell neoplasia (HP:0100728)1.55784477
143Abnormality of chromosome stability (HP:0003220)1.55619219
144Increased nuchal translucency (HP:0010880)1.55273739
145Recurrent bacterial skin infections (HP:0005406)1.55012947
146Abnormality of the labia majora (HP:0012881)1.54023084
147Ureteral obstruction (HP:0006000)1.53356454
148Cutis marmorata (HP:0000965)1.53295637
149Tapered finger (HP:0001182)1.52220186
150Abnormality of cells of the lymphoid lineage (HP:0012140)1.51996475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.13170066
2CAMK1G2.93809600
3MAP4K12.80905315
4CAMK1D2.55471758
5AKT32.49650981
6BRD42.20133654
7SIK22.16716926
8RIPK12.11752885
9ACVR1B2.10192820
10EEF2K2.05559013
11FGFR32.02465484
12MAP3K101.94990841
13NLK1.91824512
14JAK11.85891702
15TXK1.67701797
16SGK31.64055734
17JAK31.55400541
18MAP3K131.55011410
19ITK1.53824540
20TYK21.43984834
21WNK11.39197918
22SGK21.37896415
23MAP3K141.37665437
24PTK61.35226418
25TTN1.34772946
26CDK61.31846928
27PDGFRB1.29977951
28LATS11.29919120
29BLK1.27096193
30STK101.26979152
31RIPK41.26073667
32MAP3K71.25779590
33FGFR21.24005060
34FGFR41.22837751
35PRPF4B1.21947692
36MAP3K21.21538883
37PKN21.16850129
38ALK1.15638851
39SIK11.14869278
40MTOR1.13166194
41HCK1.10698490
42TAOK31.09284487
43MKNK21.06889682
44PIK3CA1.05478265
45TRIB31.05401467
46PRKCH1.04304329
47MAPK111.03647585
48STK381.02495711
49CDC42BPA1.01720410
50NEK20.99915265
51PIK3CG0.98590610
52PNCK0.98341759
53CHUK0.97902147
54GRK60.96620522
55FRK0.92172797
56ZAP700.91191298
57CDK90.91093655
58CSF1R0.88173850
59DMPK0.87805832
60PRKAA20.87291906
61BMPR1B0.86765862
62CSK0.85993021
63CAMKK10.85755991
64SCYL20.83229777
65PDGFRA0.82910978
66TYRO30.81873138
67LCK0.81685618
68MARK30.78207781
69ATR0.76483392
70NEK60.75918168
71CDC70.75670757
72RET0.73989850
73SYK0.73586388
74IKBKE0.73219207
75MAP3K60.73093360
76HIPK20.72810456
77SGK10.72721114
78CDK40.72172912
79MARK20.72146063
80JAK20.72068764
81CAMKK20.71222979
82STK30.70747659
83TGFBR20.70661833
84BTK0.69666419
85PDK10.68987521
86MELK0.68851972
87CAMK40.68151139
88ICK0.67274477
89RPS6KB20.66283599
90NEK90.66093195
91ATM0.65887256
92MAPK70.65345864
93EPHB10.65265243
94KIT0.64199871
95CHEK10.63155178
96STK110.62985821
97NUAK10.62391269
98MAP3K90.62255980
99BMPR20.61765886
100OBSCN0.61382803
101MAP3K40.60842472
102TRPM70.60626388
103FGFR10.59232950
104NTRK20.59022707
105BRSK20.57923535
106PIM10.56595677
107PRKDC0.55654907
108MAP2K30.55285433
109PRKCQ0.50604305
110KSR10.50480840
111STK40.50019375
112MAPK100.49971049
113IRAK10.49864917
114KSR20.49853387
115TAOK10.49788062
116FGR0.49774050
117MAPK80.48874353
118ERBB20.47957657
119MAPK140.47513287
120YES10.47019954
121SGK2230.46663952
122SGK4940.46663952
123CSNK1A1L0.46463007
124TEC0.46287858
125RPS6KB10.45394186
126STK390.44933348
127STK38L0.41912520
128TGFBR10.41381153

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.26224460
2B cell receptor signaling pathway_Homo sapiens_hsa046621.93607917
3T cell receptor signaling pathway_Homo sapiens_hsa046601.76821817
4Phosphatidylinositol signaling system_Homo sapiens_hsa040701.68235251
5Lysine degradation_Homo sapiens_hsa003101.67562763
6Type II diabetes mellitus_Homo sapiens_hsa049301.61954678
7Osteoclast differentiation_Homo sapiens_hsa043801.49976371
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.44129780
9mTOR signaling pathway_Homo sapiens_hsa041501.41891998
10Chronic myeloid leukemia_Homo sapiens_hsa052201.41406491
11Dorso-ventral axis formation_Homo sapiens_hsa043201.41256398
12Long-term potentiation_Homo sapiens_hsa047201.25625897
13Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22474258
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22208713
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22005411
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18973774
17Measles_Homo sapiens_hsa051621.16366455
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16041959
19Neurotrophin signaling pathway_Homo sapiens_hsa047221.15088345
20Inositol phosphate metabolism_Homo sapiens_hsa005621.14299841
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12541934
22Non-small cell lung cancer_Homo sapiens_hsa052231.11091872
23Toxoplasmosis_Homo sapiens_hsa051451.10703564
24Acute myeloid leukemia_Homo sapiens_hsa052211.08959290
25Pancreatic cancer_Homo sapiens_hsa052121.07876580
26Chemokine signaling pathway_Homo sapiens_hsa040621.05523026
27Endometrial cancer_Homo sapiens_hsa052131.05227868
28Leishmaniasis_Homo sapiens_hsa051401.05163518
29Antigen processing and presentation_Homo sapiens_hsa046121.04373236
30MicroRNAs in cancer_Homo sapiens_hsa052061.02712097
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02600908
32Hematopoietic cell lineage_Homo sapiens_hsa046401.01763927
33Circadian rhythm_Homo sapiens_hsa047101.00941430
34Platelet activation_Homo sapiens_hsa046111.00403421
35Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99610387
36Small cell lung cancer_Homo sapiens_hsa052220.98650798
37ABC transporters_Homo sapiens_hsa020100.98571280
38Colorectal cancer_Homo sapiens_hsa052100.98223017
39Thyroid cancer_Homo sapiens_hsa052160.97964498
40Glioma_Homo sapiens_hsa052140.97589950
41Influenza A_Homo sapiens_hsa051640.96863072
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.96796745
43Insulin resistance_Homo sapiens_hsa049310.96580426
44Proteoglycans in cancer_Homo sapiens_hsa052050.95524598
45Viral myocarditis_Homo sapiens_hsa054160.94641297
46Hepatitis B_Homo sapiens_hsa051610.94558817
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93774331
48Estrogen signaling pathway_Homo sapiens_hsa049150.92978368
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92696475
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92379243
51FoxO signaling pathway_Homo sapiens_hsa040680.91714290
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91375633
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.90666685
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.90232339
55TNF signaling pathway_Homo sapiens_hsa046680.89802647
56Adherens junction_Homo sapiens_hsa045200.89663399
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87752004
58Prolactin signaling pathway_Homo sapiens_hsa049170.87430296
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87048706
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86867237
61Herpes simplex infection_Homo sapiens_hsa051680.86741834
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86547800
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85249215
64HTLV-I infection_Homo sapiens_hsa051660.84929814
65ErbB signaling pathway_Homo sapiens_hsa040120.84063707
66Choline metabolism in cancer_Homo sapiens_hsa052310.82996584
67MAPK signaling pathway_Homo sapiens_hsa040100.82828202
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.82384014
69GnRH signaling pathway_Homo sapiens_hsa049120.82016486
70Salivary secretion_Homo sapiens_hsa049700.81534783
71Gastric acid secretion_Homo sapiens_hsa049710.81174749
72Prostate cancer_Homo sapiens_hsa052150.79552833
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79259809
74VEGF signaling pathway_Homo sapiens_hsa043700.79005510
75Oxytocin signaling pathway_Homo sapiens_hsa049210.77649224
76Notch signaling pathway_Homo sapiens_hsa043300.76926611
77Circadian entrainment_Homo sapiens_hsa047130.76051735
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74594003
79Renin secretion_Homo sapiens_hsa049240.74182436
80Glutamatergic synapse_Homo sapiens_hsa047240.73719571
81Tuberculosis_Homo sapiens_hsa051520.73448439
82Viral carcinogenesis_Homo sapiens_hsa052030.72096144
83cAMP signaling pathway_Homo sapiens_hsa040240.70451500
84Apoptosis_Homo sapiens_hsa042100.70306294
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.70265733
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70185697
87Long-term depression_Homo sapiens_hsa047300.69938129
88Focal adhesion_Homo sapiens_hsa045100.69465219
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67946236
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.67073496
91Cholinergic synapse_Homo sapiens_hsa047250.66561414
92Renal cell carcinoma_Homo sapiens_hsa052110.66167198
93Morphine addiction_Homo sapiens_hsa050320.63095413
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62778686
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62740809
96Insulin signaling pathway_Homo sapiens_hsa049100.62058801
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61857310
98Hepatitis C_Homo sapiens_hsa051600.61181806
99Graft-versus-host disease_Homo sapiens_hsa053320.60254381
100Rap1 signaling pathway_Homo sapiens_hsa040150.59992384
101Fatty acid biosynthesis_Homo sapiens_hsa000610.59531371
102AMPK signaling pathway_Homo sapiens_hsa041520.59466682
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57792329
104Glucagon signaling pathway_Homo sapiens_hsa049220.57441533
105Olfactory transduction_Homo sapiens_hsa047400.56932607
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.56416323
107HIF-1 signaling pathway_Homo sapiens_hsa040660.56205709
108Pathways in cancer_Homo sapiens_hsa052000.56174442
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56068840
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.55849422
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55451418
112TGF-beta signaling pathway_Homo sapiens_hsa043500.53908397
113* mRNA surveillance pathway_Homo sapiens_hsa030150.53572281
114Cell cycle_Homo sapiens_hsa041100.52721379
115Staphylococcus aureus infection_Homo sapiens_hsa051500.51809212
116Melanoma_Homo sapiens_hsa052180.50951494

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