SMC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.19067350
2nuclear pore complex assembly (GO:0051292)4.98288326
3protein localization to chromosome, centromeric region (GO:0071459)4.84267107
4mitotic sister chromatid cohesion (GO:0007064)4.74084857
5nuclear pore organization (GO:0006999)4.70877613
6* mitotic chromosome condensation (GO:0007076)4.65805506
7* kinetochore organization (GO:0051383)4.58183585
8DNA unwinding involved in DNA replication (GO:0006268)4.57433933
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.47429392
10mitotic metaphase plate congression (GO:0007080)4.26572234
11attachment of spindle microtubules to kinetochore (GO:0008608)4.26432425
12CENP-A containing nucleosome assembly (GO:0034080)4.24159816
13chromatin remodeling at centromere (GO:0031055)4.23008701
14* sister chromatid segregation (GO:0000819)4.22106202
15* mitotic sister chromatid segregation (GO:0000070)4.08054491
16kinetochore assembly (GO:0051382)4.07099309
17metaphase plate congression (GO:0051310)4.04236627
18regulation of spindle organization (GO:0090224)3.93652629
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.93323570
20DNA replication-independent nucleosome assembly (GO:0006336)3.92688664
21DNA replication-independent nucleosome organization (GO:0034724)3.92688664
22mitotic nuclear envelope disassembly (GO:0007077)3.87667878
23pore complex assembly (GO:0046931)3.87646242
24establishment of chromosome localization (GO:0051303)3.86871953
25DNA strand elongation involved in DNA replication (GO:0006271)3.86843278
26histone exchange (GO:0043486)3.79332661
27mitotic recombination (GO:0006312)3.78395343
28positive regulation of mitotic sister chromatid separation (GO:1901970)3.74661827
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.74661827
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.74661827
31DNA replication initiation (GO:0006270)3.72482891
32DNA topological change (GO:0006265)3.70587769
33DNA strand elongation (GO:0022616)3.68727377
34telomere maintenance via semi-conservative replication (GO:0032201)3.66372007
35telomere maintenance via recombination (GO:0000722)3.63485814
36regulation of DNA endoreduplication (GO:0032875)3.61890469
37positive regulation of chromosome segregation (GO:0051984)3.59925591
38nuclear envelope disassembly (GO:0051081)3.59885715
39membrane disassembly (GO:0030397)3.59885715
40protein localization to chromosome (GO:0034502)3.59130523
41regulation of histone H3-K9 methylation (GO:0051570)3.57844923
42DNA replication-dependent nucleosome assembly (GO:0006335)3.56068590
43DNA replication-dependent nucleosome organization (GO:0034723)3.56068590
44regulation of mitotic spindle organization (GO:0060236)3.55221924
45double-strand break repair via nonhomologous end joining (GO:0006303)3.49486300
46non-recombinational repair (GO:0000726)3.49486300
47chromatin assembly or disassembly (GO:0006333)3.47504082
48establishment of integrated proviral latency (GO:0075713)3.47340217
49DNA replication checkpoint (GO:0000076)3.46184744
50DNA duplex unwinding (GO:0032508)3.43976477
51DNA geometric change (GO:0032392)3.42995173
52regulation of chromosome segregation (GO:0051983)3.42211470
53regulation of sister chromatid cohesion (GO:0007063)3.42140578
54spindle checkpoint (GO:0031577)3.36691706
55* chromosome segregation (GO:0007059)3.33187403
56* meiotic chromosome segregation (GO:0045132)3.31397546
57regulation of mitotic metaphase/anaphase transition (GO:0030071)3.29681964
58regulation of centriole replication (GO:0046599)3.27624116
59* chromosome condensation (GO:0030261)3.26499351
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25330130
61synapsis (GO:0007129)3.24616403
62regulation of double-strand break repair via homologous recombination (GO:0010569)3.24094853
63translesion synthesis (GO:0019985)3.23965840
64ATP-dependent chromatin remodeling (GO:0043044)3.23867977
65spindle assembly checkpoint (GO:0071173)3.21791014
66regulation of centrosome cycle (GO:0046605)3.19692111
67* mitotic cell cycle (GO:0000278)3.19090998
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18965148
69* DNA conformation change (GO:0071103)3.15037859
70negative regulation of chromosome segregation (GO:0051985)3.14310408
71regulation of mitotic sister chromatid segregation (GO:0033047)3.13379360
72regulation of sister chromatid segregation (GO:0033045)3.13379360
73regulation of mitotic sister chromatid separation (GO:0010965)3.13379360
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.12521115
75negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12521115
76negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12521115
77negative regulation of sister chromatid segregation (GO:0033046)3.12521115
78regulation of RNA export from nucleus (GO:0046831)3.09480497
79ribosomal small subunit assembly (GO:0000028)3.08224650
80telomere maintenance via telomere lengthening (GO:0010833)3.08024718
81regulation of double-strand break repair (GO:2000779)3.07555873
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.07449744
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07394060
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06524950
85mitotic spindle assembly checkpoint (GO:0007094)3.06169085
86* DNA packaging (GO:0006323)3.06009103
87mitotic spindle checkpoint (GO:0071174)3.05762225
88negative regulation of DNA repair (GO:0045738)3.03335810
89resolution of meiotic recombination intermediates (GO:0000712)3.01605424
90spindle organization (GO:0007051)3.00835674
91mitotic spindle organization (GO:0007052)3.00706485
92negative regulation of mitosis (GO:0045839)3.00199936
93sister chromatid cohesion (GO:0007062)3.00155180
94spindle assembly involved in mitosis (GO:0090307)2.98336303
95negative regulation of histone methylation (GO:0031061)2.98296401
96dosage compensation (GO:0007549)2.96924503
97chromatin assembly (GO:0031497)2.96590003
98protein K6-linked ubiquitination (GO:0085020)2.94148659
99microtubule depolymerization (GO:0007019)2.92104902
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.89359686
101telomere maintenance (GO:0000723)2.86202652
102DNA synthesis involved in DNA repair (GO:0000731)2.86146498
103telomere organization (GO:0032200)2.83312343
104monoubiquitinated protein deubiquitination (GO:0035520)2.82777834
105nuclear envelope organization (GO:0006998)2.80953174
106postreplication repair (GO:0006301)2.79672250
107* chromosome organization (GO:0051276)2.78232319
108DNA ligation (GO:0006266)2.77577280
109heterochromatin organization (GO:0070828)2.77067945
110V(D)J recombination (GO:0033151)2.74830164
111regulation of centrosome duplication (GO:0010824)2.71387028
112mitotic G2/M transition checkpoint (GO:0044818)2.70406484
113maturation of SSU-rRNA (GO:0030490)2.70038366
114mitotic DNA integrity checkpoint (GO:0044774)2.67700028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.52505772
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.82737990
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.02910968
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.12814183
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.00946431
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.94882534
7AR_21909140_ChIP-Seq_LNCAP_Human2.62824817
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50055630
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.44949267
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26363173
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17707426
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14552057
13MYC_22102868_ChIP-Seq_BL_Human2.04736744
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.02422727
15E2F7_22180533_ChIP-Seq_HELA_Human10.7042735
16NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99759828
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99604230
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95788507
19* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94565559
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91785060
21VDR_23849224_ChIP-Seq_CD4+_Human1.85931919
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85174447
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78279045
24* XRN2_22483619_ChIP-Seq_HELA_Human1.78166425
25ELK1_19687146_ChIP-ChIP_HELA_Human1.76858425
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73410801
27FOXP3_21729870_ChIP-Seq_TREG_Human1.71996985
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69472394
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68897341
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68513154
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65424268
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.62593548
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.61067178
34* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60374190
35CIITA_25753668_ChIP-Seq_RAJI_Human1.59225067
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58496023
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57499272
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.55439476
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.54291605
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50263710
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48078894
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44919487
43TTF2_22483619_ChIP-Seq_HELA_Human1.43520388
44DCP1A_22483619_ChIP-Seq_HELA_Human1.42923882
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41385245
46* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36213828
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34442816
48KDM5A_27292631_Chip-Seq_BREAST_Human1.33951712
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32658967
50MYB_26560356_Chip-Seq_TH2_Human1.29018700
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25104909
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24980694
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22894438
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22684550
55GABP_19822575_ChIP-Seq_HepG2_Human1.22592259
56* VDR_21846776_ChIP-Seq_THP-1_Human1.22138519
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21782053
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21474120
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21358105
60MYB_26560356_Chip-Seq_TH1_Human1.21269911
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21061994
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20112959
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18751216
64SPI1_23547873_ChIP-Seq_NB4_Human1.15161613
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14126631
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12708967
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12677362
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10074827
69* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08357184
70UTX_26944678_Chip-Seq_JUKART_Human1.07459976
71* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06364643
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03215786
73MAF_26560356_Chip-Seq_TH1_Human1.01780315
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00880907
75CHD1_26751641_Chip-Seq_LNCaP_Human1.00243421
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99584840
77* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97857096
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96406777
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95860042
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95755044
81* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95454268
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93904938
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93425681
84TFEB_21752829_ChIP-Seq_HELA_Human0.93331733
85KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92549184
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92248823
87THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91909973
88MYC_18940864_ChIP-ChIP_HL60_Human0.91589370
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91252382
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.90942997
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89920479
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.86311740
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85505755
94BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84310649
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84013591
96SCL_19346495_ChIP-Seq_HPC-7_Human0.83802707
97RUNX1_22412390_ChIP-Seq_EML_Mouse0.83779660
98PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83697850
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.83645863
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83387580
101NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82929471
102IRF8_22096565_ChIP-ChIP_GC-B_Human0.81858045
103* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81392316
104FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80414453
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80145457
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79723674
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.79682512
108PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79550311
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79474520
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.79227739
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.78729506
112EWS_26573619_Chip-Seq_HEK293_Human0.78567544
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78373747
114* TCF7_22412390_ChIP-Seq_EML_Mouse0.77283562
115* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76662398
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.75555041
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72463047
118ZNF263_19887448_ChIP-Seq_K562_Human0.69774940
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.68885572
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.66270229
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.65858337
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.64676118
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.60549497
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.59820425
125FUS_26573619_Chip-Seq_HEK293_Human0.59800616
126SRF_21415370_ChIP-Seq_HL-1_Mouse0.59296008
127WT1_19549856_ChIP-ChIP_CCG9911_Human0.59154277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.54088799
2MP0003693_abnormal_embryo_hatching4.24422630
3MP0008057_abnormal_DNA_replication3.95393063
4MP0003111_abnormal_nucleus_morphology3.84483314
5MP0003077_abnormal_cell_cycle3.63062513
6MP0004957_abnormal_blastocyst_morpholog3.40005666
7MP0008877_abnormal_DNA_methylation2.75721989
8MP0002396_abnormal_hematopoietic_system2.73010411
9MP0008058_abnormal_DNA_repair2.71850459
10MP0008007_abnormal_cellular_replicative2.67650805
11MP0009697_abnormal_copulation2.41725187
12MP0003763_abnormal_thymus_physiology2.30400152
13MP0010307_abnormal_tumor_latency2.18878609
14MP0004808_abnormal_hematopoietic_stem2.16573115
15MP0010352_gastrointestinal_tract_polyps2.10023299
16MP0008932_abnormal_embryonic_tissue1.99394456
17MP0000350_abnormal_cell_proliferation1.98169469
18MP0001730_embryonic_growth_arrest1.93099660
19MP0006292_abnormal_olfactory_placode1.75776880
20MP0000703_abnormal_thymus_morphology1.68587208
21MP0005076_abnormal_cell_differentiation1.67211178
22MP0000490_abnormal_crypts_of1.67199691
23MP0002398_abnormal_bone_marrow1.59070572
24MP0003786_premature_aging1.56866277
25MP0001672_abnormal_embryogenesis/_devel1.51959273
26MP0005380_embryogenesis_phenotype1.51959273
27MP0003121_genomic_imprinting1.49538017
28MP0003123_paternal_imprinting1.47780597
29MP0001697_abnormal_embryo_size1.47156136
30MP0002019_abnormal_tumor_incidence1.45067711
31MP0005397_hematopoietic_system_phenotyp1.41117063
32MP0001545_abnormal_hematopoietic_system1.41117063
33MP0002722_abnormal_immune_system1.36395930
34MP0006054_spinal_hemorrhage1.36271503
35MP0003984_embryonic_growth_retardation1.36206477
36MP0009333_abnormal_splenocyte_physiolog1.34712565
37MP0002210_abnormal_sex_determination1.33375713
38MP0002088_abnormal_embryonic_growth/wei1.33365478
39MP0000313_abnormal_cell_death1.32146220
40MP0002166_altered_tumor_susceptibility1.31830933
41MP0004197_abnormal_fetal_growth/weight/1.31343956
42MP0002086_abnormal_extraembryonic_tissu1.31197457
43MP0000689_abnormal_spleen_morphology1.27880541
44MP0002085_abnormal_embryonic_tissue1.27866684
45MP0002080_prenatal_lethality1.27734703
46MP0002084_abnormal_developmental_patter1.26332795
47MP0009278_abnormal_bone_marrow1.25029213
48MP0004185_abnormal_adipocyte_glucose1.24482164
49MP0001929_abnormal_gametogenesis1.23982171
50MP0002006_tumorigenesis1.22370823
51MP0002697_abnormal_eye_size1.20617544
52MP0001800_abnormal_humoral_immune1.20354663
53MP0000428_abnormal_craniofacial_morphol1.19292422
54MP0000537_abnormal_urethra_morphology1.18103075
55MP0003567_abnormal_fetal_cardiomyocyte1.17999571
56MP0000716_abnormal_immune_system1.14225787
57MP0005671_abnormal_response_to1.12178341
58MP0002429_abnormal_blood_cell1.11271012
59MP0001835_abnormal_antigen_presentation1.10762970
60MP0000685_abnormal_immune_system1.10308591
61MP0001145_abnormal_male_reproductive1.09225081
62MP0001286_abnormal_eye_development1.08947380
63MP0002420_abnormal_adaptive_immunity1.08259810
64MP0001819_abnormal_immune_cell1.05880339
65MP0003787_abnormal_imprinting1.03638086
66MP0002452_abnormal_antigen_presenting1.02657690
67MP0000569_abnormal_digit_pigmentation1.02488471
68MP0002405_respiratory_system_inflammati1.01544995
69MP0004233_abnormal_muscle_weight0.99694380
70MP0002009_preneoplasia0.98539154
71MP0000653_abnormal_sex_gland0.97960942
72MP0003941_abnormal_skin_development0.96794496
73MP0003300_gastrointestinal_ulcer0.93362839
74MP0003705_abnormal_hypodermis_morpholog0.93033377
75MP0000858_altered_metastatic_potential0.92369424
76MP0003385_abnormal_body_wall0.92348271
77MP0010234_abnormal_vibrissa_follicle0.92076811
78MP0001293_anophthalmia0.91130755
79MP0002723_abnormal_immune_serum0.90948627
80MP0002111_abnormal_tail_morphology0.90904319
81MP0001346_abnormal_lacrimal_gland0.86208619
82MP0001119_abnormal_female_reproductive0.85500499
83MP0001915_intracranial_hemorrhage0.85326499
84MP0010155_abnormal_intestine_physiology0.84773264
85MP0003935_abnormal_craniofacial_develop0.84517817
86MP0003718_maternal_effect0.84507577
87MP0003890_abnormal_embryonic-extraembry0.83750491
88MP0001661_extended_life_span0.83285850
89MP0005023_abnormal_wound_healing0.82903888
90MP0002160_abnormal_reproductive_system0.82588456
91MP0000432_abnormal_head_morphology0.80404652
92MP0001873_stomach_inflammation0.80073265
93MP0002095_abnormal_skin_pigmentation0.80053800
94MP0002877_abnormal_melanocyte_morpholog0.79907488
95MP0003448_altered_tumor_morphology0.79815411
96MP0000465_gastrointestinal_hemorrhage0.79526931
97MP0003755_abnormal_palate_morphology0.78881243
98MP0009703_decreased_birth_body0.78104325
99MP0000358_abnormal_cell_content/0.77589761
100MP0003221_abnormal_cardiomyocyte_apopto0.77511459
101MP0000733_abnormal_muscle_development0.76961372
102MP0005174_abnormal_tail_pigmentation0.76657211
103MP0003861_abnormal_nervous_system0.76414096
104MP0009053_abnormal_anal_canal0.75577167
105MP0005000_abnormal_immune_tolerance0.74571265
106MP0005501_abnormal_skin_physiology0.74492171
107MP0009672_abnormal_birth_weight0.74195836
108MP0003315_abnormal_perineum_morphology0.73454393
109MP0003937_abnormal_limbs/digits/tail_de0.73376701
110MP0002233_abnormal_nose_morphology0.72561606
111MP0000383_abnormal_hair_follicle0.72266379
112MP0003699_abnormal_female_reproductive0.71582171
113MP0003566_abnormal_cell_adhesion0.69983447
114MP0005621_abnormal_cell_physiology0.69634292
115MP0002234_abnormal_pharynx_morphology0.69627554
116MP0000566_synostosis0.68727091
117MP0000647_abnormal_sebaceous_gland0.68424559
118MP0002092_abnormal_eye_morphology0.68158492
119MP0004947_skin_inflammation0.68027256
120MP0008995_early_reproductive_senescence0.67944562
121MP0003698_abnormal_male_reproductive0.67240173
122MP0003656_abnormal_erythrocyte_physiolo0.66717593
123MP0003115_abnormal_respiratory_system0.66082556
124MP0010030_abnormal_orbit_morphology0.65881267
125MP0010678_abnormal_skin_adnexa0.65687631
126MP0005384_cellular_phenotype0.65028943
127MP0002114_abnormal_axial_skeleton0.64705501
128MP0003950_abnormal_plasma_membrane0.64383629
129MP0002938_white_spotting0.62843097
130MP0002925_abnormal_cardiovascular_devel0.62737095
131MP0001853_heart_inflammation0.62301919
132MP0001790_abnormal_immune_system0.62247884
133MP0005387_immune_system_phenotype0.62247884
134MP0005025_abnormal_response_to0.62237891
135MP0005623_abnormal_meninges_morphology0.61249963
136MP0003943_abnormal_hepatobiliary_system0.60940486
137MP0002249_abnormal_larynx_morphology0.58850182
138MP0000627_abnormal_mammary_gland0.57683218
139MP0002161_abnormal_fertility/fecundity0.57395322
140MP0003119_abnormal_digestive_system0.54691180
141MP0003942_abnormal_urinary_system0.54329218
142MP0006035_abnormal_mitochondrial_morpho0.53476390

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.42501641
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.96025657
3Volvulus (HP:0002580)3.93382136
4Abnormality of chromosome stability (HP:0003220)3.59193112
5Reticulocytopenia (HP:0001896)3.19591342
6Cortical dysplasia (HP:0002539)3.03081948
7Increased nuchal translucency (HP:0010880)2.97763731
8Ectopic kidney (HP:0000086)2.95848738
9T lymphocytopenia (HP:0005403)2.93620366
10Myelodysplasia (HP:0002863)2.93088490
11Birth length less than 3rd percentile (HP:0003561)2.92318267
12Abnormality of the preputium (HP:0100587)2.91653209
13Meckel diverticulum (HP:0002245)2.87789894
14Abnormality of the fingertips (HP:0001211)2.86416109
15Selective tooth agenesis (HP:0001592)2.84983716
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.80661116
17Abnormality of T cell number (HP:0011839)2.73471396
1811 pairs of ribs (HP:0000878)2.72801859
19Abnormality of the ileum (HP:0001549)2.70661815
20Impulsivity (HP:0100710)2.69728900
21Duodenal stenosis (HP:0100867)2.65136942
22Small intestinal stenosis (HP:0012848)2.65136942
23Colon cancer (HP:0003003)2.59608881
24Medulloblastoma (HP:0002885)2.59508607
25Abnormality of chromosome segregation (HP:0002916)2.54182522
26Proximal placement of thumb (HP:0009623)2.51149983
27Deviation of the thumb (HP:0009603)2.48357847
28Sloping forehead (HP:0000340)2.44851221
29Combined immunodeficiency (HP:0005387)2.43681709
30Degeneration of anterior horn cells (HP:0002398)2.43299386
31Abnormality of the anterior horn cell (HP:0006802)2.43299386
32Acute myeloid leukemia (HP:0004808)2.42590754
33Basal cell carcinoma (HP:0002671)2.42363926
34High pitched voice (HP:0001620)2.40723544
35Absent forearm bone (HP:0003953)2.37877674
36Aplasia involving forearm bones (HP:0009822)2.37877674
37Short 4th metacarpal (HP:0010044)2.37809823
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37809823
39Abnormality of B cell number (HP:0010975)2.37267008
40B lymphocytopenia (HP:0010976)2.37267008
41Abnormality of cochlea (HP:0000375)2.36010824
42Prominent nose (HP:0000448)2.34507206
43Patellar aplasia (HP:0006443)2.32553882
44Triphalangeal thumb (HP:0001199)2.31920578
45Arteriovenous malformation (HP:0100026)2.31317593
46IgM deficiency (HP:0002850)2.30520523
47Severe combined immunodeficiency (HP:0004430)2.25297114
48Embryonal neoplasm (HP:0002898)2.24814146
49Rhabdomyosarcoma (HP:0002859)2.23495487
50Abnormal lung lobation (HP:0002101)2.22012234
51Abnormality of T cells (HP:0002843)2.21982487
52Nephroblastoma (Wilms tumor) (HP:0002667)2.20788910
53Thrombocytosis (HP:0001894)2.19006928
54Abnormality of the carotid arteries (HP:0005344)2.18725232
55Recurrent viral infections (HP:0004429)2.16530361
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16168605
57Choanal atresia (HP:0000453)2.15983000
58Aplasia/Hypoplasia of the patella (HP:0006498)2.15721959
59Recurrent bronchitis (HP:0002837)2.13509443
60Deep philtrum (HP:0002002)2.12442470
61Abnormality of the duodenum (HP:0002246)2.11489380
62Clubbing of toes (HP:0100760)2.11176833
63Lymphoma (HP:0002665)2.11122578
64Duplication of thumb phalanx (HP:0009942)2.10061165
65Absent thumb (HP:0009777)2.09800700
66Cafe-au-lait spot (HP:0000957)2.08716857
67Abnormality of cells of the erythroid lineage (HP:0012130)2.07308781
68Squamous cell carcinoma (HP:0002860)2.06305523
69Thyroiditis (HP:0100646)2.05608721
70Embryonal renal neoplasm (HP:0011794)2.05116765
71Bone marrow hypocellularity (HP:0005528)2.00085730
72Neoplasm of the colon (HP:0100273)1.99911057
73Acute lymphatic leukemia (HP:0006721)1.99886307
74Long eyelashes (HP:0000527)1.99404162
75Abnormal number of erythroid precursors (HP:0012131)1.98356565
76High anterior hairline (HP:0009890)1.98289312
77Abnormality of DNA repair (HP:0003254)1.97168949
78Ependymoma (HP:0002888)1.95532130
79Horseshoe kidney (HP:0000085)1.95161085
80Agnosia (HP:0010524)1.93197983
81Breast hypoplasia (HP:0003187)1.90795138
82Amaurosis fugax (HP:0100576)1.89797485
83Atresia of the external auditory canal (HP:0000413)1.89099118
84Capillary hemangiomas (HP:0005306)1.88285366
85Heterotopia (HP:0002282)1.87961081
86Cutaneous melanoma (HP:0012056)1.87742583
87Obsessive-compulsive behavior (HP:0000722)1.87300420
88Duplicated collecting system (HP:0000081)1.86245867
89Blepharitis (HP:0000498)1.85456111
90Facial hemangioma (HP:0000329)1.85056655
91Microvesicular hepatic steatosis (HP:0001414)1.84519383
92Short thumb (HP:0009778)1.83122349
93Abnormality of the labia minora (HP:0012880)1.82997212
94Ankyloglossia (HP:0010296)1.81803865
95Abnormality of the calcaneus (HP:0008364)1.81777382
96Missing ribs (HP:0000921)1.81738083
97IgG deficiency (HP:0004315)1.81175287
98Absent radius (HP:0003974)1.80621989
99Panhypogammaglobulinemia (HP:0003139)1.80404162
100Neoplasm of the pancreas (HP:0002894)1.79510657
101Abnormal number of incisors (HP:0011064)1.79350342
102Glioma (HP:0009733)1.78250976
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.77215645
104Poikiloderma (HP:0001029)1.75411140
105Aplastic anemia (HP:0001915)1.75083059
106Cutis marmorata (HP:0000965)1.74947405
107Truncal obesity (HP:0001956)1.73574889
108Biliary tract neoplasm (HP:0100574)1.73446004
109Eosinophilia (HP:0001880)1.73263437
110Abnormality of the phalanges of the hallux (HP:0010057)1.71589125
111Progressive external ophthalmoplegia (HP:0000590)1.70955507
112Sandal gap (HP:0001852)1.70795347
113Absent frontal sinuses (HP:0002688)1.70776570
114Morphological abnormality of the inner ear (HP:0011390)1.70106589
115Aplasia/Hypoplasia of the thymus (HP:0010515)1.69725668
116Dislocated radial head (HP:0003083)1.69228284
117Supernumerary spleens (HP:0009799)1.69169963
118Broad palm (HP:0001169)1.67933398
119Entropion (HP:0000621)1.67492816
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67233332
121Oligodactyly (HP:0012165)1.66286111
122Astrocytoma (HP:0009592)1.66242310
123Abnormality of the astrocytes (HP:0100707)1.66242310
124Pallor (HP:0000980)1.66064362
125Tracheoesophageal fistula (HP:0002575)1.65854999
126Overlapping toe (HP:0001845)1.65831208
127Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65816868
128Short middle phalanx of the 5th finger (HP:0004220)1.65540629
129Uterine leiomyosarcoma (HP:0002891)1.64828515
130Leiomyosarcoma (HP:0100243)1.64828515
131Abnormality of the renal collecting system (HP:0004742)1.64802370
132Premature graying of hair (HP:0002216)1.64550542
133Malignant gastrointestinal tract tumors (HP:0006749)1.63422695
134Gastrointestinal carcinoma (HP:0002672)1.63422695
135Long clavicles (HP:0000890)1.62559975
136Abnormal umbilical cord blood vessels (HP:0011403)1.61659370
137Single umbilical artery (HP:0001195)1.61659370
138Abnormality of the fetal cardiovascular system (HP:0010948)1.61659370
139Radioulnar synostosis (HP:0002974)1.59768247
140Neoplasm of striated muscle (HP:0009728)1.56717241
141Oligodactyly (hands) (HP:0001180)1.55838447
142Microglossia (HP:0000171)1.55756462
143Progressive muscle weakness (HP:0003323)1.53980931
144Abnormal foot bone ossification (HP:0010675)1.53705474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.08203383
2NEK23.66200088
3WEE13.09859303
4BUB12.94691968
5CDK122.52543659
6TTK2.52375002
7STK102.46302169
8SRPK12.23885244
9PLK42.11692550
10EEF2K1.95974015
11MKNK11.95011376
12MAP4K11.92703024
13AURKB1.89958448
14EIF2AK11.89259910
15BRSK21.89118887
16PLK11.88798462
17ATR1.88284691
18STK41.80329700
19RPS6KA41.75113296
20ACVR1B1.68464970
21PASK1.66038535
22CHEK21.61085549
23CDK41.56007541
24TAF11.54945628
25RPS6KB21.49245296
26MKNK21.48619915
27SMG11.45954272
28MAP3K101.42056248
29TLK11.40695375
30TXK1.40139047
31CDK61.38234359
32CHEK11.37940112
33NEK11.36414059
34MAP3K81.36069204
35PLK31.35037843
36CDK71.32157865
37CCNB11.31918303
38PKN21.24313758
39BRD41.20846327
40STK31.20059826
41ATM1.19525514
42MELK1.12337514
43VRK11.10043383
44DYRK31.08914429
45JAK31.07256027
46MET1.06114549
47TSSK61.05397201
48VRK21.05083662
49PIM11.04216233
50MST1R1.03224558
51ZAK1.02696200
52TGFBR11.01769935
53LRRK20.99898941
54CLK10.96576349
55BRSK10.95891398
56BRAF0.95494725
57NME20.94337770
58TEC0.87688498
59TESK20.87050107
60* CDK20.85626909
61CAMK1G0.82213970
62CDK90.81634636
63ZAP700.80371824
64AURKA0.79110543
65EIF2AK30.78381157
66BTK0.76827367
67ITK0.75808268
68CDK10.73908431
69PDK40.73872211
70PDK30.73872211
71RPS6KA50.72933693
72SCYL20.71419137
73MARK30.69024748
74ICK0.64051630
75FLT30.63331161
76NEK90.63115679
77FGFR30.62765503
78NUAK10.61638110
79LATS20.61417395
80EIF2AK20.59568730
81GRK60.59228205
82KSR10.58450859
83CDK30.57784938
84PAK40.56612071
85TRPM70.56425161
86LCK0.53267913
87NLK0.52891698
88ERBB30.50975000
89ALK0.50961610
90TESK10.50767962
91ERBB40.50758678
92TTN0.49031819
93RAF10.47930122
94TYK20.47591124
95CSNK2A20.46950586
96LATS10.45822661
97CHUK0.44639113
98CSNK2A10.44437205
99MTOR0.44304119
100PBK0.43026710
101STK38L0.42519430
102CSF1R0.41764573
103YES10.41715368
104PRKDC0.41571344
105AKT20.40586099
106PNCK0.40424114
107CSNK1E0.39733040
108CDK80.38984710
109MST40.37369481
110PDGFRA0.37163132
111CDK11A0.36148868
112MAPK140.36033204
113TRIB30.35759161
114FGFR10.35393239
115CSNK1D0.34454957
116CSK0.34397934
117CDK150.33248540
118CDK180.33233314
119KSR20.32747029
120KIT0.32376729
121BMX0.32226306
122CAMK1D0.31800130
123MAP2K30.31665189
124BCR0.29679168
125IRAK40.29574571
126TAOK30.28939219
127PLK20.28866958
128AKT10.28657012
129* GSK3B0.26596463
130PDK20.25143519
131MAPK110.24808436
132CDK140.24346375
133PAK20.23476598

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.34837848
2Mismatch repair_Homo sapiens_hsa034303.72980810
3Cell cycle_Homo sapiens_hsa041103.12846504
4Homologous recombination_Homo sapiens_hsa034403.06091379
5Spliceosome_Homo sapiens_hsa030402.85817614
6Base excision repair_Homo sapiens_hsa034102.82501415
7Fanconi anemia pathway_Homo sapiens_hsa034602.72205262
8RNA transport_Homo sapiens_hsa030132.71287061
9Non-homologous end-joining_Homo sapiens_hsa034502.68559061
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63858059
11Nucleotide excision repair_Homo sapiens_hsa034202.47947954
12Ribosome_Homo sapiens_hsa030102.06790058
13One carbon pool by folate_Homo sapiens_hsa006701.98922318
14mRNA surveillance pathway_Homo sapiens_hsa030151.96509926
15Systemic lupus erythematosus_Homo sapiens_hsa053221.96198558
16RNA degradation_Homo sapiens_hsa030181.95092430
17Primary immunodeficiency_Homo sapiens_hsa053401.88404715
18p53 signaling pathway_Homo sapiens_hsa041151.85112258
19Basal transcription factors_Homo sapiens_hsa030221.82999941
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64113469
21Pyrimidine metabolism_Homo sapiens_hsa002401.54849069
22RNA polymerase_Homo sapiens_hsa030201.54825176
23Antigen processing and presentation_Homo sapiens_hsa046121.54804947
24Viral carcinogenesis_Homo sapiens_hsa052031.45453307
25Herpes simplex infection_Homo sapiens_hsa051681.43290135
26Proteasome_Homo sapiens_hsa030501.24985015
27HTLV-I infection_Homo sapiens_hsa051661.20827578
28Epstein-Barr virus infection_Homo sapiens_hsa051691.19184512
29MicroRNAs in cancer_Homo sapiens_hsa052061.14962297
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14462015
31Measles_Homo sapiens_hsa051621.14448580
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.11297042
33Oocyte meiosis_Homo sapiens_hsa041141.10141269
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09488139
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08653688
36Small cell lung cancer_Homo sapiens_hsa052221.07794500
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.05290019
38Biosynthesis of amino acids_Homo sapiens_hsa012301.02813512
39T cell receptor signaling pathway_Homo sapiens_hsa046600.98160939
40Hematopoietic cell lineage_Homo sapiens_hsa046400.95278383
41Protein export_Homo sapiens_hsa030600.93351365
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.92378299
43Hepatitis B_Homo sapiens_hsa051610.88636166
44Chronic myeloid leukemia_Homo sapiens_hsa052200.87868930
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86403666
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85451478
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84810976
48Viral myocarditis_Homo sapiens_hsa054160.82387524
49Bladder cancer_Homo sapiens_hsa052190.81201227
50Alcoholism_Homo sapiens_hsa050340.76836331
51Legionellosis_Homo sapiens_hsa051340.76815301
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76499218
53Thyroid cancer_Homo sapiens_hsa052160.76387898
54Colorectal cancer_Homo sapiens_hsa052100.76286931
55Apoptosis_Homo sapiens_hsa042100.75494047
56B cell receptor signaling pathway_Homo sapiens_hsa046620.74287227
57Purine metabolism_Homo sapiens_hsa002300.74131932
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.73551425
59Pancreatic cancer_Homo sapiens_hsa052120.72464921
60Pyruvate metabolism_Homo sapiens_hsa006200.70586374
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70216627
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70212496
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68488869
64Leishmaniasis_Homo sapiens_hsa051400.68006785
65Influenza A_Homo sapiens_hsa051640.67994355
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.65523098
67Folate biosynthesis_Homo sapiens_hsa007900.63993013
68Prostate cancer_Homo sapiens_hsa052150.62427153
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.62414624
70Shigellosis_Homo sapiens_hsa051310.61979035
71Adherens junction_Homo sapiens_hsa045200.60899005
72Carbon metabolism_Homo sapiens_hsa012000.59630432
73TGF-beta signaling pathway_Homo sapiens_hsa043500.59386809
74Notch signaling pathway_Homo sapiens_hsa043300.58863356
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57046544
76Acute myeloid leukemia_Homo sapiens_hsa052210.56548842
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56057370
78Toxoplasmosis_Homo sapiens_hsa051450.55874942
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55834354
80Steroid biosynthesis_Homo sapiens_hsa001000.55529505
81Glioma_Homo sapiens_hsa052140.55248355
82Non-small cell lung cancer_Homo sapiens_hsa052230.54332838
83Melanoma_Homo sapiens_hsa052180.52858321
84Selenocompound metabolism_Homo sapiens_hsa004500.52390436
85Lysine degradation_Homo sapiens_hsa003100.52147630
86Wnt signaling pathway_Homo sapiens_hsa043100.51710708
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51350172
88Osteoclast differentiation_Homo sapiens_hsa043800.50840245
89Pathways in cancer_Homo sapiens_hsa052000.49157217
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46991524
91Allograft rejection_Homo sapiens_hsa053300.46942583
92FoxO signaling pathway_Homo sapiens_hsa040680.45433754
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45397583
94Sulfur relay system_Homo sapiens_hsa041220.45072631
95Graft-versus-host disease_Homo sapiens_hsa053320.44988193
96Hedgehog signaling pathway_Homo sapiens_hsa043400.43661639
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43377507
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43172373
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42372418
100Pentose phosphate pathway_Homo sapiens_hsa000300.41200654
101Basal cell carcinoma_Homo sapiens_hsa052170.41186768
102Platelet activation_Homo sapiens_hsa046110.40455946
103Renal cell carcinoma_Homo sapiens_hsa052110.39032149
104TNF signaling pathway_Homo sapiens_hsa046680.38878073
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38006049
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36228584
107Proteoglycans in cancer_Homo sapiens_hsa052050.36127363
108Hippo signaling pathway_Homo sapiens_hsa043900.35512483
109mTOR signaling pathway_Homo sapiens_hsa041500.35325349
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34905745
111Asthma_Homo sapiens_hsa053100.34148753
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33678433
113HIF-1 signaling pathway_Homo sapiens_hsa040660.33249193
114Autoimmune thyroid disease_Homo sapiens_hsa053200.33095808
115Propanoate metabolism_Homo sapiens_hsa006400.32983208
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31643488
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31080872
118Endometrial cancer_Homo sapiens_hsa052130.30814588
119ErbB signaling pathway_Homo sapiens_hsa040120.29303872
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28201421
121N-Glycan biosynthesis_Homo sapiens_hsa005100.27995780
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25853187
123Salmonella infection_Homo sapiens_hsa051320.25761197
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25049899
125Malaria_Homo sapiens_hsa051440.24739962
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24694332
127Dorso-ventral axis formation_Homo sapiens_hsa043200.23983188
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23684561
129Vitamin B6 metabolism_Homo sapiens_hsa007500.22255095
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19915875
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17760653
132Inositol phosphate metabolism_Homo sapiens_hsa005620.13880336
133AMPK signaling pathway_Homo sapiens_hsa041520.10007529
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.08851188
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08404091

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