SMC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.47777068
2nuclear pore organization (GO:0006999)5.36970567
3DNA unwinding involved in DNA replication (GO:0006268)4.90539791
4kinetochore organization (GO:0051383)4.88742212
5* mitotic sister chromatid cohesion (GO:0007064)4.64588230
6protein localization to kinetochore (GO:0034501)4.60763455
7mitotic chromosome condensation (GO:0007076)4.32945160
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.18134839
9pore complex assembly (GO:0046931)4.16759879
10kinetochore assembly (GO:0051382)4.09810881
11mitotic nuclear envelope disassembly (GO:0007077)4.08874692
12mitotic metaphase plate congression (GO:0007080)4.04661496
13DNA ligation (GO:0006266)4.02599788
14establishment of integrated proviral latency (GO:0075713)4.01183276
15synapsis (GO:0007129)4.00303315
16DNA strand elongation involved in DNA replication (GO:0006271)3.99067601
17chromatin remodeling at centromere (GO:0031055)3.99051900
18DNA replication initiation (GO:0006270)3.98661681
19sister chromatid segregation (GO:0000819)3.98655273
20protein localization to chromosome, centromeric region (GO:0071459)3.98041322
21CENP-A containing nucleosome assembly (GO:0034080)3.90761031
22metaphase plate congression (GO:0051310)3.85479496
23DNA strand elongation (GO:0022616)3.82821585
24mitotic sister chromatid segregation (GO:0000070)3.81805386
25membrane disassembly (GO:0030397)3.81567946
26nuclear envelope disassembly (GO:0051081)3.81567946
27DNA replication-independent nucleosome assembly (GO:0006336)3.80632418
28DNA replication-independent nucleosome organization (GO:0034724)3.80632418
29DNA replication-dependent nucleosome organization (GO:0034723)3.79738852
30DNA replication-dependent nucleosome assembly (GO:0006335)3.79738852
31DNA double-strand break processing (GO:0000729)3.77213591
32attachment of spindle microtubules to kinetochore (GO:0008608)3.74677930
33meiotic chromosome segregation (GO:0045132)3.74603171
34regulation of meiosis I (GO:0060631)3.70177458
35mitotic recombination (GO:0006312)3.69941668
36telomere maintenance via semi-conservative replication (GO:0032201)3.69881603
37DNA replication checkpoint (GO:0000076)3.68156539
38centriole replication (GO:0007099)3.61538334
39DNA duplex unwinding (GO:0032508)3.61019520
40DNA geometric change (GO:0032392)3.60440439
41regulation of sister chromatid cohesion (GO:0007063)3.59320523
42regulation of histone H3-K9 methylation (GO:0051570)3.55402114
43regulation of RNA export from nucleus (GO:0046831)3.55253222
44regulation of spindle organization (GO:0090224)3.54534528
45telomere maintenance via recombination (GO:0000722)3.53461567
46resolution of meiotic recombination intermediates (GO:0000712)3.53377209
47spindle checkpoint (GO:0031577)3.50432781
48DNA topological change (GO:0006265)3.50425500
49positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48425113
50positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48425113
51positive regulation of mitotic sister chromatid separation (GO:1901970)3.48425113
52positive regulation of chromosome segregation (GO:0051984)3.48296695
53histone exchange (GO:0043486)3.48117204
54regulation of mitotic metaphase/anaphase transition (GO:0030071)3.48082546
55regulation of centriole replication (GO:0046599)3.46110783
56spindle assembly checkpoint (GO:0071173)3.44939016
57regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.42115979
58negative regulation of chromosome segregation (GO:0051985)3.41856773
59mitotic spindle checkpoint (GO:0071174)3.40914072
60negative regulation of mitotic sister chromatid separation (GO:2000816)3.40794534
61negative regulation of mitotic sister chromatid segregation (GO:0033048)3.40794534
62negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.40794534
63negative regulation of sister chromatid segregation (GO:0033046)3.40794534
64establishment of chromosome localization (GO:0051303)3.40290816
65negative regulation of histone methylation (GO:0031061)3.39508115
66non-recombinational repair (GO:0000726)3.37720353
67double-strand break repair via nonhomologous end joining (GO:0006303)3.37720353
68mitotic spindle assembly checkpoint (GO:0007094)3.37629694
69chromatin assembly or disassembly (GO:0006333)3.36925895
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36879537
71regulation of mitotic spindle checkpoint (GO:1903504)3.36879537
72regulation of chromosome segregation (GO:0051983)3.36568622
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.33287447
74regulation of mitotic sister chromatid separation (GO:0010965)3.31978379
75regulation of mitotic sister chromatid segregation (GO:0033047)3.31978379
76regulation of sister chromatid segregation (GO:0033045)3.31978379
77ATP-dependent chromatin remodeling (GO:0043044)3.31203899
78mitotic G2/M transition checkpoint (GO:0044818)3.27888828
79replication fork processing (GO:0031297)3.26842962
80pre-miRNA processing (GO:0031054)3.26463304
81negative regulation of DNA recombination (GO:0045910)3.25199451
82heterochromatin organization (GO:0070828)3.24994713
83protein localization to chromosome (GO:0034502)3.24877768
84telomere maintenance via telomere lengthening (GO:0010833)3.23925843
85regulation of mitotic spindle organization (GO:0060236)3.22357639
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.22290988
87regulation of centrosome cycle (GO:0046605)3.18393063
88DNA conformation change (GO:0071103)3.15396446
89microtubule depolymerization (GO:0007019)3.15202313
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14377022
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12243257
92chromosome segregation (GO:0007059)3.11770388
93IMP biosynthetic process (GO:0006188)3.09710885
94chromatin assembly (GO:0031497)3.08976510
95DNA synthesis involved in DNA repair (GO:0000731)3.08393406
96* negative regulation of DNA-dependent DNA replication (GO:2000104)3.06864959
97regulation of helicase activity (GO:0051095)3.06183857
98* regulation of DNA endoreduplication (GO:0032875)3.02782933
99intra-S DNA damage checkpoint (GO:0031573)3.00590146
100postreplication repair (GO:0006301)2.99012872
101formation of translation preinitiation complex (GO:0001731)2.98535876
102chromosome organization involved in meiosis (GO:0070192)2.97831783
103regulation of nuclear cell cycle DNA replication (GO:0033262)2.97765319
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.94667813
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94230300
106somatic hypermutation of immunoglobulin genes (GO:0016446)2.94230300
107ribosome assembly (GO:0042255)2.93778675
108mismatch repair (GO:0006298)2.93487456
109regulation of double-strand break repair via homologous recombination (GO:0010569)2.93191146
110DNA catabolic process, exonucleolytic (GO:0000738)2.92650261
111maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92385772
112translesion synthesis (GO:0019985)2.92036976
113nuclear envelope organization (GO:0006998)2.91483392
114* sister chromatid cohesion (GO:0007062)2.91341656
115negative regulation of mitosis (GO:0045839)2.90881158
116chromosome condensation (GO:0030261)2.90467886
117RNA splicing, via transesterification reactions (GO:0000375)2.90428219
118positive regulation of histone H3-K4 methylation (GO:0051571)2.90120530
119regulation of centrosome duplication (GO:0010824)2.89701272
120RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.89364826
121mRNA splicing, via spliceosome (GO:0000398)2.89364826
122nucleobase biosynthetic process (GO:0046112)2.89304660
123establishment of viral latency (GO:0019043)2.89242795
124negative regulation of RNA splicing (GO:0033119)2.87296906
125dosage compensation (GO:0007549)2.87017557
126DNA packaging (GO:0006323)2.81608590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.70782945
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.85002580
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.84395608
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.76290729
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.06970390
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.79858504
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72705163
8AR_21909140_ChIP-Seq_LNCAP_Human2.69617759
9* E2F1_21310950_ChIP-Seq_MCF-7_Human2.64821567
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54754593
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47703143
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46654653
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45818302
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35843411
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32902466
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.31977691
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.28489049
18* SALL1_21062744_ChIP-ChIP_HESCs_Human2.20013461
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18051915
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17484938
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.15342741
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07216072
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04426207
24XRN2_22483619_ChIP-Seq_HELA_Human2.02850589
25E2F7_22180533_ChIP-Seq_HELA_Human11.3046189
26YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95701678
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95330412
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93426789
29VDR_23849224_ChIP-Seq_CD4+_Human1.85297326
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82095113
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.79798595
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.79373422
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79339320
34ELK1_19687146_ChIP-ChIP_HELA_Human1.77078608
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70294242
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.70264000
37TTF2_22483619_ChIP-Seq_HELA_Human1.68963434
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63659537
39CIITA_25753668_ChIP-Seq_RAJI_Human1.62972820
40MYC_22102868_ChIP-Seq_BL_Human1.59620387
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58687696
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56706828
43ZNF274_21170338_ChIP-Seq_K562_Hela1.55357287
44IGF1R_20145208_ChIP-Seq_DFB_Human1.51891957
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49063163
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46820192
47KDM5A_27292631_Chip-Seq_BREAST_Human1.46280509
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45510436
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44998965
50* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42874471
51VDR_22108803_ChIP-Seq_LS180_Human1.41565999
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41257941
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41055649
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40178943
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37336653
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36991275
57* DCP1A_22483619_ChIP-Seq_HELA_Human1.35303026
58GABP_19822575_ChIP-Seq_HepG2_Human1.35060087
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29994047
60TAF15_26573619_Chip-Seq_HEK293_Human1.29970292
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28579559
62* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25011657
63* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20213212
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19833584
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17053533
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16491991
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16130562
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15942244
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15139288
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13519692
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13137971
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12912630
73* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12822951
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11789837
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.10301855
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07620827
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06691437
78P300_19829295_ChIP-Seq_ESCs_Human1.06333991
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01814343
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.01730474
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01340068
82TFEB_21752829_ChIP-Seq_HELA_Human0.98456440
83KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97867554
84MYC_18940864_ChIP-ChIP_HL60_Human0.97756813
85IRF1_19129219_ChIP-ChIP_H3396_Human0.97317821
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97242400
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94966548
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94665001
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94542349
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94542349
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94542349
92ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94054823
93EWS_26573619_Chip-Seq_HEK293_Human0.93798196
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.93785067
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93304420
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92611417
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.92408427
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92316614
99PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91939458
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91753171
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91264306
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89967190
103SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89488937
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89041744
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88738914
106* CHD1_26751641_Chip-Seq_LNCaP_Human0.88313587
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.87694646
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.87158695
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86855909
110TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86764745
111SRF_21415370_ChIP-Seq_HL-1_Mouse0.83961721
112TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83255882
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82780469
114CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82537884
115* SOX9_26525672_Chip-Seq_HEART_Mouse0.81362399
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.80529208
117FUS_26573619_Chip-Seq_HEK293_Human0.80479989
118* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78122549
119* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77708986
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.77557618
121* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77025943
122YY1_21170310_ChIP-Seq_MESCs_Mouse0.75638832
123* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75582305
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.75166601
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73310683
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.72680949
127PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72245468
128* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.72045722
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71953983
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.71247824
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.69973872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.30080381
2MP0008057_abnormal_DNA_replication4.24910830
3MP0003693_abnormal_embryo_hatching3.75214719
4MP0003111_abnormal_nucleus_morphology3.72492050
5MP0004957_abnormal_blastocyst_morpholog3.56461277
6MP0003077_abnormal_cell_cycle3.48749952
7MP0008877_abnormal_DNA_methylation3.08480302
8MP0008058_abnormal_DNA_repair2.86792916
9MP0003123_paternal_imprinting2.60941912
10MP0008007_abnormal_cellular_replicative2.55485760
11MP0003121_genomic_imprinting2.39647564
12MP0010352_gastrointestinal_tract_polyps2.35994191
13MP0008932_abnormal_embryonic_tissue2.27371336
14MP0001730_embryonic_growth_arrest2.18400420
15MP0000350_abnormal_cell_proliferation2.09551405
16MP0010307_abnormal_tumor_latency1.90273234
17MP0003890_abnormal_embryonic-extraembry1.87773306
18MP0002396_abnormal_hematopoietic_system1.83225936
19MP0002084_abnormal_developmental_patter1.82065665
20MP0010030_abnormal_orbit_morphology1.79204723
21MP0001672_abnormal_embryogenesis/_devel1.76677159
22MP0005380_embryogenesis_phenotype1.76677159
23MP0009697_abnormal_copulation1.76386478
24MP0004197_abnormal_fetal_growth/weight/1.74332249
25MP0001697_abnormal_embryo_size1.74302455
26MP0002085_abnormal_embryonic_tissue1.73720325
27MP0005076_abnormal_cell_differentiation1.70492510
28MP0000537_abnormal_urethra_morphology1.67587182
29MP0001293_anophthalmia1.64296140
30MP0001188_hyperpigmentation1.62667436
31MP0003567_abnormal_fetal_cardiomyocyte1.61974868
32MP0003984_embryonic_growth_retardation1.61089567
33MP0002088_abnormal_embryonic_growth/wei1.58768935
34MP0003786_premature_aging1.55351283
35MP0003937_abnormal_limbs/digits/tail_de1.54535729
36MP0001529_abnormal_vocalization1.50206382
37MP0009053_abnormal_anal_canal1.49000004
38MP0002086_abnormal_extraembryonic_tissu1.48786979
39MP0004808_abnormal_hematopoietic_stem1.46930867
40MP0002080_prenatal_lethality1.42400178
41MP0003787_abnormal_imprinting1.41624127
42MP0005394_taste/olfaction_phenotype1.36798267
43MP0005499_abnormal_olfactory_system1.36798267
44MP0006292_abnormal_olfactory_placode1.33613357
45MP0002102_abnormal_ear_morphology1.31380300
46MP0002938_white_spotting1.31176259
47MP0003941_abnormal_skin_development1.29407571
48MP0002210_abnormal_sex_determination1.29282043
49MP0003315_abnormal_perineum_morphology1.21565448
50MP0003136_yellow_coat_color1.20512936
51MP0009703_decreased_birth_body1.19052927
52MP0000428_abnormal_craniofacial_morphol1.15661556
53MP0003119_abnormal_digestive_system1.15568287
54MP0000778_abnormal_nervous_system1.12591775
55MP0000313_abnormal_cell_death1.12503574
56MP0001145_abnormal_male_reproductive1.11736410
57MP0003935_abnormal_craniofacial_develop1.08816034
58MP0003755_abnormal_palate_morphology1.05492382
59MP0001286_abnormal_eye_development1.05045441
60MP0009672_abnormal_birth_weight1.04924924
61MP0000490_abnormal_crypts_of1.04117915
62MP0002092_abnormal_eye_morphology1.03521079
63MP0002009_preneoplasia1.03411473
64MP0000432_abnormal_head_morphology1.02734012
65MP0000569_abnormal_digit_pigmentation1.02426474
66MP0000631_abnormal_neuroendocrine_gland1.02339171
67MP0002019_abnormal_tumor_incidence1.01643453
68MP0003698_abnormal_male_reproductive0.99894865
69MP0002160_abnormal_reproductive_system0.98821781
70MP0000653_abnormal_sex_gland0.98369788
71MP0003385_abnormal_body_wall0.97683714
72MP0001929_abnormal_gametogenesis0.97497594
73MP0003122_maternal_imprinting0.94999608
74MP0006035_abnormal_mitochondrial_morpho0.94815814
75MP0000647_abnormal_sebaceous_gland0.93446227
76MP0002697_abnormal_eye_size0.93308168
77MP0003115_abnormal_respiratory_system0.89868936
78MP0000566_synostosis0.89867822
79MP0002234_abnormal_pharynx_morphology0.89325380
80MP0003861_abnormal_nervous_system0.89029481
81MP0002111_abnormal_tail_morphology0.88644524
82MP0000703_abnormal_thymus_morphology0.87946551
83MP0001915_intracranial_hemorrhage0.86473726
84MP0005253_abnormal_eye_physiology0.85180005
85MP0000049_abnormal_middle_ear0.84787554
86MP0008995_early_reproductive_senescence0.83647672
87MP0006054_spinal_hemorrhage0.82296739
88MP0004133_heterotaxia0.82022975
89MP0000383_abnormal_hair_follicle0.81942384
90MP0000733_abnormal_muscle_development0.81814531
91MP0003705_abnormal_hypodermis_morpholog0.81456954
92MP0002653_abnormal_ependyma_morphology0.81361167
93MP0001177_atelectasis0.80344947
94MP0002925_abnormal_cardiovascular_devel0.79386105
95MP0002116_abnormal_craniofacial_bone0.79341642
96MP0008789_abnormal_olfactory_epithelium0.78974863
97MP0005187_abnormal_penis_morphology0.78534162
98MP0002932_abnormal_joint_morphology0.77920894
99MP0003942_abnormal_urinary_system0.77408860
100MP0002114_abnormal_axial_skeleton0.77347455
101MP0003283_abnormal_digestive_organ0.76519879
102MP0002161_abnormal_fertility/fecundity0.76076743
103MP0002233_abnormal_nose_morphology0.75634966
104MP0000516_abnormal_urinary_system0.74832809
105MP0005367_renal/urinary_system_phenotyp0.74832809
106MP0001299_abnormal_eye_distance/0.74073636
107MP0000358_abnormal_cell_content/0.73889536
108MP0010678_abnormal_skin_adnexa0.73384429
109MP0001119_abnormal_female_reproductive0.72677532
110MP0006072_abnormal_retinal_apoptosis0.72030171
111MP0010234_abnormal_vibrissa_follicle0.71765209
112MP0003699_abnormal_female_reproductive0.71020029
113MP0004264_abnormal_extraembryonic_tissu0.70812224
114MP0005391_vision/eye_phenotype0.69823117
115MP0003718_maternal_effect0.68896424
116MP0001545_abnormal_hematopoietic_system0.68558833
117MP0005397_hematopoietic_system_phenotyp0.68558833
118MP0002081_perinatal_lethality0.68504684
119MP0002877_abnormal_melanocyte_morpholog0.68313892
120MP0002751_abnormal_autonomic_nervous0.68150449
121MP0001849_ear_inflammation0.66883972
122MP0009250_abnormal_appendicular_skeleto0.66285952
123MP0002736_abnormal_nociception_after0.65966129
124MP0002095_abnormal_skin_pigmentation0.64522769
125MP0003943_abnormal_hepatobiliary_system0.63950295
126MP0003938_abnormal_ear_development0.63915764
127MP0001485_abnormal_pinna_reflex0.61446508
128MP0002152_abnormal_brain_morphology0.61296227
129MP0005395_other_phenotype0.60564413
130MP0005389_reproductive_system_phenotype0.59294497

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.83486162
2* Volvulus (HP:0002580)3.55284902
3Medulloblastoma (HP:0002885)3.49221418
4Colon cancer (HP:0003003)3.44901849
5Birth length less than 3rd percentile (HP:0003561)3.43436728
6Ependymoma (HP:0002888)3.33075552
7Cortical dysplasia (HP:0002539)3.30752008
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27306475
9Abnormality of chromosome stability (HP:0003220)3.04196638
10* Increased nuchal translucency (HP:0010880)2.96489761
11Short 4th metacarpal (HP:0010044)2.92352458
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.92352458
13Abnormality of the labia minora (HP:0012880)2.91936458
14Patellar aplasia (HP:0006443)2.89925393
15Selective tooth agenesis (HP:0001592)2.88943078
16Ectopic kidney (HP:0000086)2.88240839
17* Proximal placement of thumb (HP:0009623)2.74613697
18Oligodactyly (hands) (HP:0001180)2.71918623
19Rhabdomyosarcoma (HP:0002859)2.71629845
20* Deviation of the thumb (HP:0009603)2.67976020
21Aplasia/Hypoplasia of the patella (HP:0006498)2.67302813
22Astrocytoma (HP:0009592)2.64461581
23Abnormality of the astrocytes (HP:0100707)2.64461581
24Abnormal number of incisors (HP:0011064)2.63445812
25Intestinal atresia (HP:0011100)2.62964043
26Meckel diverticulum (HP:0002245)2.60795311
27Neoplasm of the oral cavity (HP:0100649)2.53922022
28Glioma (HP:0009733)2.53853338
29Breast hypoplasia (HP:0003187)2.49020718
30Abnormality of the ileum (HP:0001549)2.48331101
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.47752574
32Aplasia/Hypoplasia of the sternum (HP:0006714)2.45415587
33Abnormality of the preputium (HP:0100587)2.45367975
34Reticulocytopenia (HP:0001896)2.43199580
35Abnormal lung lobation (HP:0002101)2.40591599
36Impulsivity (HP:0100710)2.40363365
37Small intestinal stenosis (HP:0012848)2.39352101
38Duodenal stenosis (HP:0100867)2.39352101
39Abnormality of the fingertips (HP:0001211)2.37947486
40Facial hemangioma (HP:0000329)2.37585774
41Nephroblastoma (Wilms tumor) (HP:0002667)2.35117945
42Septo-optic dysplasia (HP:0100842)2.32062525
43Absent radius (HP:0003974)2.28633726
44Embryonal renal neoplasm (HP:0011794)2.24352751
45Prominent nose (HP:0000448)2.20863908
46* Long eyelashes (HP:0000527)2.19815026
47Neoplasm of striated muscle (HP:0009728)2.18457473
48* Atresia of the external auditory canal (HP:0000413)2.17932526
49Supernumerary spleens (HP:0009799)2.17063959
50Myelodysplasia (HP:0002863)2.16343445
51Absent forearm bone (HP:0003953)2.16043597
52Aplasia involving forearm bones (HP:0009822)2.16043597
53Biliary tract neoplasm (HP:0100574)2.15294403
54Deep philtrum (HP:0002002)2.14730001
55Abnormality of the carotid arteries (HP:0005344)2.06938560
56Sloping forehead (HP:0000340)2.04328607
57Gastrointestinal atresia (HP:0002589)2.02068984
58Supernumerary ribs (HP:0005815)2.00048222
59Embryonal neoplasm (HP:0002898)1.99714529
6011 pairs of ribs (HP:0000878)1.99160785
61Agnosia (HP:0010524)1.99022442
62Malignant gastrointestinal tract tumors (HP:0006749)1.98845098
63Gastrointestinal carcinoma (HP:0002672)1.98845098
64Bifid tongue (HP:0010297)1.98781675
65Abnormality of the duodenum (HP:0002246)1.96889216
66Clubbing of toes (HP:0100760)1.96657477
67Gonadotropin excess (HP:0000837)1.95481582
68Renal duplication (HP:0000075)1.95467199
69Supernumerary bones of the axial skeleton (HP:0009144)1.94982864
70Cafe-au-lait spot (HP:0000957)1.94752470
71Missing ribs (HP:0000921)1.94663435
72Neoplasm of the pancreas (HP:0002894)1.94454732
73Abdominal situs inversus (HP:0003363)1.94401169
74Abnormality of abdominal situs (HP:0011620)1.94401169
75Basal cell carcinoma (HP:0002671)1.94073899
76Abnormality of the septum pellucidum (HP:0007375)1.93436770
77Abnormality of the 4th metacarpal (HP:0010012)1.93275099
78Absent thumb (HP:0009777)1.92005388
79Shawl scrotum (HP:0000049)1.91069621
80Trigonocephaly (HP:0000243)1.89946017
81High anterior hairline (HP:0009890)1.89502338
82Absent septum pellucidum (HP:0001331)1.89230902
83Abnormality of the anterior horn cell (HP:0006802)1.85699984
84Degeneration of anterior horn cells (HP:0002398)1.85699984
85Short thumb (HP:0009778)1.85389838
86Median cleft lip (HP:0000161)1.84272148
87Hypoplastic pelvis (HP:0008839)1.82809904
88Abnormal hair whorl (HP:0010721)1.81904876
89Neoplasm of the colon (HP:0100273)1.80255399
90Papillary thyroid carcinoma (HP:0002895)1.79996867
91Sandal gap (HP:0001852)1.79215478
92High pitched voice (HP:0001620)1.78562856
93Rib fusion (HP:0000902)1.77551844
94Hyperglycinemia (HP:0002154)1.76565453
95Preaxial hand polydactyly (HP:0001177)1.76383853
96Abnormality of chromosome segregation (HP:0002916)1.76341436
97Broad palm (HP:0001169)1.76320572
98Skull defect (HP:0001362)1.75843438
99Premature graying of hair (HP:0002216)1.75043727
100Hypoplastic labia majora (HP:0000059)1.72991261
101Facial cleft (HP:0002006)1.72517867
102Ovarian neoplasm (HP:0100615)1.72064888
103Oligodactyly (HP:0012165)1.71890134
104Acute myeloid leukemia (HP:0004808)1.71391176
105Broad thumb (HP:0011304)1.71364011
106Acute lymphatic leukemia (HP:0006721)1.70194554
107Pancreatic fibrosis (HP:0100732)1.69177712
108Abnormality of the incisor (HP:0000676)1.68253780
109Short tibia (HP:0005736)1.67845539
110Microtia (HP:0008551)1.67693251
111Esophageal atresia (HP:0002032)1.67603227
112Duplicated collecting system (HP:0000081)1.67312756
113Dandy-Walker malformation (HP:0001305)1.67184646
114Triphalangeal thumb (HP:0001199)1.66587330
115Aplasia/Hypoplasia of the tibia (HP:0005772)1.65388067
116* Choanal atresia (HP:0000453)1.65214014
117Optic nerve coloboma (HP:0000588)1.64706847
118Multiple enchondromatosis (HP:0005701)1.63761555
119Overlapping toe (HP:0001845)1.63752820
120Hepatoblastoma (HP:0002884)1.63287012
121Aplasia/hypoplasia of the humerus (HP:0006507)1.63042764
122Horseshoe kidney (HP:0000085)1.61908133
123Abnormality of the phalanges of the hallux (HP:0010057)1.61805691
124Astigmatism (HP:0000483)1.61697084
125Tracheoesophageal fistula (HP:0002575)1.61518614
126Shoulder girdle muscle weakness (HP:0003547)1.61298490
127Aplasia/Hypoplasia of the sacrum (HP:0008517)1.61227972
128Chronic hepatic failure (HP:0100626)1.58984158
129Abnormality of midbrain morphology (HP:0002418)1.58651024
130Molar tooth sign on MRI (HP:0002419)1.58651024
131Aplasia/Hypoplasia of the earlobes (HP:0009906)1.58338897
132Neoplasm of the small intestine (HP:0100833)1.57476998
133Arteriovenous malformation (HP:0100026)1.56125985
134Nephronophthisis (HP:0000090)1.53737072
135Neoplasm of the adrenal cortex (HP:0100641)1.53092947
136Duplication of thumb phalanx (HP:0009942)1.52269983
137Postaxial foot polydactyly (HP:0001830)1.48742586
138Pancreatic islet-cell hyperplasia (HP:0004510)1.47083919
139Irregular epiphyses (HP:0010582)1.46368095
140Holoprosencephaly (HP:0001360)1.45466194
141Micropenis (HP:0000054)1.44907966
142Carpal bone hypoplasia (HP:0001498)1.44802244
143Increased hepatocellular lipid droplets (HP:0006565)1.43717422
144Optic nerve hypoplasia (HP:0000609)1.43277509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.67722596
2CDK123.97673369
3WEE13.64376828
4NEK22.93706649
5BUB12.75161765
6TTK2.68440847
7SRPK12.53473149
8MKNK12.49294120
9PLK42.28378823
10ACVR1B2.14327177
11BRD42.14313582
12ATR2.14289196
13PLK12.08769390
14PASK2.08215547
15NEK12.08186738
16BRSK22.04261546
17PLK32.03779029
18TNIK2.02939995
19TSSK61.89027302
20EIF2AK11.86314354
21AURKB1.86205187
22MKNK21.74360426
23CDK71.73246851
24CHEK21.71248546
25TAF11.70836058
26CHEK11.68061668
27VRK21.66164662
28TRIM281.64579018
29PNCK1.64430382
30WNK31.51363871
31RPS6KB21.49921826
32VRK11.46632737
33* ATM1.42198086
34DYRK31.40806052
35CDK41.37492101
36STK101.34181173
37CDK61.29479187
38LATS11.25765269
39BMPR1B1.25316565
40TGFBR11.23189897
41EEF2K1.23095306
42RPS6KA41.18278953
43STK161.18093790
44CASK1.17772961
45CDK21.17295066
46STK31.17087787
47STK41.15357734
48MAP3K81.13450177
49MELK1.12248828
50MAP3K41.11163397
51MST41.07800156
52ZAK1.06490929
53BRSK11.02999897
54CDK11.02681836
55EIF2AK30.97102570
56MAP3K100.89763999
57TLK10.89136849
58ALK0.89014534
59AURKA0.87084897
60SCYL20.83648004
61MAP3K90.82738347
62CSNK1G20.80280008
63NUAK10.79490869
64CDK80.79384627
65MTOR0.78424786
66PAK40.78136544
67CDK190.77735737
68CDK90.72618813
69STK38L0.71224496
70CLK10.71164039
71BRAF0.70833787
72CSNK1D0.70240322
73DYRK20.68754124
74CSNK1A1L0.68019201
75CAMK1D0.66967879
76CSNK1E0.66308637
77TESK20.65981495
78FGFR10.65864370
79* CSNK2A20.65334896
80PIM10.65023419
81* PRKDC0.64274344
82CCNB10.63953518
83PBK0.63096766
84STK390.60415328
85CDK30.59121821
86MAPK140.58572477
87MAP2K70.56697797
88ERBB30.56401599
89CSNK1G10.53815585
90RPS6KA50.53515733
91PAK20.53473055
92* CSNK2A10.52967048
93CSNK1G30.52925512
94MAPK130.50751373
95MAP4K20.47298914
96EPHA20.46765207
97GSK3B0.46667101
98BCR0.44126683
99WNK40.42855741
100AKT10.42486390
101YES10.41584609
102CDK180.41236538
103EIF2AK20.40932554
104CDK11A0.40500676
105CAMK1G0.39138427
106MAPK10.38462427
107ERBB40.37779786
108CDK150.37589079
109MINK10.37079517
110CDK140.37030630
111RPS6KB10.36706934
112OXSR10.33226874
113PRKCG0.32319237
114FGFR20.31493028
115PKN20.31453168
116PLK20.31387406
117PRKACB0.31084693
118PAK10.30309600
119MAPK100.29726996
120PDGFRA0.27932186
121MAPK80.27399212
122LRRK20.27356415
123STK240.25943913
124AKT20.24736112
125FLT30.24459488
126MAPK90.23833216
127KSR10.23353434
128PDGFRB0.20384575
129PRKCI0.20022858

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61529345
2Mismatch repair_Homo sapiens_hsa034304.28210929
3Spliceosome_Homo sapiens_hsa030403.40158369
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30361384
5* Cell cycle_Homo sapiens_hsa041103.30075132
6RNA transport_Homo sapiens_hsa030133.22743161
7Homologous recombination_Homo sapiens_hsa034403.08001970
8Base excision repair_Homo sapiens_hsa034102.77586770
9Nucleotide excision repair_Homo sapiens_hsa034202.69265661
10Non-homologous end-joining_Homo sapiens_hsa034502.68441645
11Fanconi anemia pathway_Homo sapiens_hsa034602.66412149
12mRNA surveillance pathway_Homo sapiens_hsa030152.38560268
13RNA polymerase_Homo sapiens_hsa030202.29715745
14One carbon pool by folate_Homo sapiens_hsa006702.25640843
15RNA degradation_Homo sapiens_hsa030182.19474466
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18119900
17Basal transcription factors_Homo sapiens_hsa030222.14082571
18Ribosome_Homo sapiens_hsa030102.00325783
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78327796
20p53 signaling pathway_Homo sapiens_hsa041151.63316180
21Pyrimidine metabolism_Homo sapiens_hsa002401.62842075
22Proteasome_Homo sapiens_hsa030501.57042913
23Steroid biosynthesis_Homo sapiens_hsa001001.52017404
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49810925
25Systemic lupus erythematosus_Homo sapiens_hsa053221.42057171
26Propanoate metabolism_Homo sapiens_hsa006401.40933516
27* Oocyte meiosis_Homo sapiens_hsa041141.33326256
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31816997
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31585310
30MicroRNAs in cancer_Homo sapiens_hsa052061.30382309
31Viral carcinogenesis_Homo sapiens_hsa052031.24606838
32Epstein-Barr virus infection_Homo sapiens_hsa051691.17999361
33HTLV-I infection_Homo sapiens_hsa051661.08304457
34Parkinsons disease_Homo sapiens_hsa050121.07430822
35Basal cell carcinoma_Homo sapiens_hsa052171.05839473
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04782216
37Folate biosynthesis_Homo sapiens_hsa007901.04361210
38Huntingtons disease_Homo sapiens_hsa050161.02300662
39Herpes simplex infection_Homo sapiens_hsa051681.02298932
40Colorectal cancer_Homo sapiens_hsa052101.02078156
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00617187
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98751588
43Hippo signaling pathway_Homo sapiens_hsa043900.96951659
44Vitamin B6 metabolism_Homo sapiens_hsa007500.96833751
45TGF-beta signaling pathway_Homo sapiens_hsa043500.96064417
46Oxidative phosphorylation_Homo sapiens_hsa001900.95924675
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95256078
48Adherens junction_Homo sapiens_hsa045200.95087971
49Pyruvate metabolism_Homo sapiens_hsa006200.94650787
50Thyroid cancer_Homo sapiens_hsa052160.93761345
51Purine metabolism_Homo sapiens_hsa002300.93134290
52Small cell lung cancer_Homo sapiens_hsa052220.93132743
53Antigen processing and presentation_Homo sapiens_hsa046120.89423540
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88420054
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84816100
56Alcoholism_Homo sapiens_hsa050340.82503230
57Hedgehog signaling pathway_Homo sapiens_hsa043400.80262447
58Wnt signaling pathway_Homo sapiens_hsa043100.79700930
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78291059
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76222703
61Chronic myeloid leukemia_Homo sapiens_hsa052200.72590076
62Lysine degradation_Homo sapiens_hsa003100.72577889
63Prostate cancer_Homo sapiens_hsa052150.71606246
64Notch signaling pathway_Homo sapiens_hsa043300.71196249
65Pathways in cancer_Homo sapiens_hsa052000.66589221
66Fatty acid elongation_Homo sapiens_hsa000620.66473733
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58296372
68Hepatitis B_Homo sapiens_hsa051610.57190216
69Biosynthesis of amino acids_Homo sapiens_hsa012300.56164569
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54487069
71Viral myocarditis_Homo sapiens_hsa054160.54273525
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53856434
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53698555
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52016594
75Tight junction_Homo sapiens_hsa045300.51589346
76Pancreatic cancer_Homo sapiens_hsa052120.51390633
77Endometrial cancer_Homo sapiens_hsa052130.50252006
78mTOR signaling pathway_Homo sapiens_hsa041500.48776329
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48116344
80Non-small cell lung cancer_Homo sapiens_hsa052230.46770666
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46760055
82Proteoglycans in cancer_Homo sapiens_hsa052050.45288159
83Glutathione metabolism_Homo sapiens_hsa004800.44100571
84Alzheimers disease_Homo sapiens_hsa050100.43942593
85Butanoate metabolism_Homo sapiens_hsa006500.43309730
86Circadian rhythm_Homo sapiens_hsa047100.43150177
87FoxO signaling pathway_Homo sapiens_hsa040680.42579483
88Nicotine addiction_Homo sapiens_hsa050330.42336239
89Melanoma_Homo sapiens_hsa052180.42202245
90N-Glycan biosynthesis_Homo sapiens_hsa005100.41969174
91Carbon metabolism_Homo sapiens_hsa012000.41321320
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41043662
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38991547
94Selenocompound metabolism_Homo sapiens_hsa004500.37885353
95Primary immunodeficiency_Homo sapiens_hsa053400.36940007
96Metabolic pathways_Homo sapiens_hsa011000.36779228
97Phototransduction_Homo sapiens_hsa047440.35952215
98Bladder cancer_Homo sapiens_hsa052190.34383417
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.33630046
100Regulation of autophagy_Homo sapiens_hsa041400.33355214
101Fatty acid metabolism_Homo sapiens_hsa012120.32420049
102Apoptosis_Homo sapiens_hsa042100.32293840
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32089943
104Renal cell carcinoma_Homo sapiens_hsa052110.31795066
105ECM-receptor interaction_Homo sapiens_hsa045120.30987665
106Focal adhesion_Homo sapiens_hsa045100.30874380
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.30206306
108Shigellosis_Homo sapiens_hsa051310.28649323
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26955085
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26675267
111T cell receptor signaling pathway_Homo sapiens_hsa046600.26418788
112HIF-1 signaling pathway_Homo sapiens_hsa040660.25300365
113Protein export_Homo sapiens_hsa030600.25267818
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.25067308
115Measles_Homo sapiens_hsa051620.24776289
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23653091
117Acute myeloid leukemia_Homo sapiens_hsa052210.21473254
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19142516
119Glioma_Homo sapiens_hsa052140.18960114
120Influenza A_Homo sapiens_hsa051640.18010051
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.17901059
122beta-Alanine metabolism_Homo sapiens_hsa004100.17770400
123Peroxisome_Homo sapiens_hsa041460.17758841
124Hematopoietic cell lineage_Homo sapiens_hsa046400.17542343
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16957354
126Vitamin digestion and absorption_Homo sapiens_hsa049770.16852463
127Legionellosis_Homo sapiens_hsa051340.16581267
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16188311
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16052393
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.15575700
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15086834
132Axon guidance_Homo sapiens_hsa043600.13981204
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.13830823
134Renin-angiotensin system_Homo sapiens_hsa046140.13359454
135Cardiac muscle contraction_Homo sapiens_hsa042600.13116230
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.12020565
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11671567
138Melanogenesis_Homo sapiens_hsa049160.11634094
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10635418
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10463184
141Taste transduction_Homo sapiens_hsa047420.10198773
142Olfactory transduction_Homo sapiens_hsa047400.08719891
143Arginine and proline metabolism_Homo sapiens_hsa003300.08277475
144Fatty acid degradation_Homo sapiens_hsa000710.07608969
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06521280
146Sulfur relay system_Homo sapiens_hsa041220.03448143

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