SMC1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.68761600
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.40599788
3protein localization to kinetochore (GO:0034501)5.03615284
4* mitotic sister chromatid cohesion (GO:0007064)5.01812443
5nuclear pore complex assembly (GO:0051292)4.70951549
6nuclear pore organization (GO:0006999)4.61733309
7mitotic chromosome condensation (GO:0007076)4.55669441
8kinetochore organization (GO:0051383)4.55554088
9DNA topological change (GO:0006265)4.42733371
10ribosomal small subunit assembly (GO:0000028)4.41346117
11DNA strand elongation involved in DNA replication (GO:0006271)4.39075774
12DNA synthesis involved in DNA repair (GO:0000731)4.35975482
13protein localization to chromosome, centromeric region (GO:0071459)4.23240676
14DNA strand elongation (GO:0022616)4.18386107
15regulation of translational fidelity (GO:0006450)4.07372148
16* sister chromatid segregation (GO:0000819)4.06564609
17telomere maintenance via semi-conservative replication (GO:0032201)3.99362492
18mitotic recombination (GO:0006312)3.97712920
19DNA replication initiation (GO:0006270)3.85033975
20heterochromatin organization (GO:0070828)3.82928979
21DNA duplex unwinding (GO:0032508)3.80575547
22DNA geometric change (GO:0032392)3.80246593
23telomere maintenance via recombination (GO:0000722)3.78900245
24non-recombinational repair (GO:0000726)3.78517228
25double-strand break repair via nonhomologous end joining (GO:0006303)3.78517228
26spliceosomal tri-snRNP complex assembly (GO:0000244)3.76290235
27* mitotic sister chromatid segregation (GO:0000070)3.68862794
28regulation of spindle organization (GO:0090224)3.68551566
29mitotic metaphase plate congression (GO:0007080)3.65570801
30pore complex assembly (GO:0046931)3.64910695
31attachment of spindle microtubules to kinetochore (GO:0008608)3.64282823
32mitotic nuclear envelope disassembly (GO:0007077)3.63513122
33* regulation of DNA endoreduplication (GO:0032875)3.61406409
34viral transcription (GO:0019083)3.60479446
35positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.59960771
36positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.59960771
37positive regulation of mitotic sister chromatid separation (GO:1901970)3.59960771
38negative regulation of RNA splicing (GO:0033119)3.58757064
39CENP-A containing nucleosome assembly (GO:0034080)3.57569274
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.57176169
41translational termination (GO:0006415)3.56402913
42nuclear envelope organization (GO:0006998)3.52944610
43metaphase plate congression (GO:0051310)3.52074571
44regulation of sister chromatid cohesion (GO:0007063)3.50132016
45folic acid-containing compound biosynthetic process (GO:0009396)3.49693619
46DNA replication-independent nucleosome organization (GO:0034724)3.49238460
47DNA replication-independent nucleosome assembly (GO:0006336)3.49238460
48alternative mRNA splicing, via spliceosome (GO:0000380)3.49202047
49regulation of nucleobase-containing compound transport (GO:0032239)3.48776990
50chromatin remodeling at centromere (GO:0031055)3.46060483
51DNA replication-dependent nucleosome assembly (GO:0006335)3.43012683
52DNA replication-dependent nucleosome organization (GO:0034723)3.43012683
53establishment of integrated proviral latency (GO:0075713)3.42604117
54ribosome assembly (GO:0042255)3.40763738
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.40277279
56kinetochore assembly (GO:0051382)3.39539224
57DNA replication checkpoint (GO:0000076)3.38664452
58regulation of mitotic spindle organization (GO:0060236)3.37008497
59V(D)J recombination (GO:0033151)3.36097929
60nuclear envelope disassembly (GO:0051081)3.34721907
61membrane disassembly (GO:0030397)3.34721907
62* sister chromatid cohesion (GO:0007062)3.34244358
63telomere maintenance via telomere lengthening (GO:0010833)3.33765275
64DNA conformation change (GO:0071103)3.33522760
65IMP biosynthetic process (GO:0006188)3.33194421
66translesion synthesis (GO:0019985)3.33007331
67positive regulation of chromosome segregation (GO:0051984)3.32913713
68regulation of histone H3-K9 methylation (GO:0051570)3.32803953
69establishment of chromosome localization (GO:0051303)3.30681285
70maturation of SSU-rRNA (GO:0030490)3.28081478
71dosage compensation (GO:0007549)3.23507411
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.22801658
73negative regulation of histone methylation (GO:0031061)3.22454356
74mRNA transport (GO:0051028)3.19905182
75chromosome condensation (GO:0030261)3.18498457
76meiotic chromosome segregation (GO:0045132)3.17274194
77negative regulation of chromosome segregation (GO:0051985)3.17177131
78ribosomal small subunit biogenesis (GO:0042274)3.16442426
79negative regulation of mRNA processing (GO:0050686)3.16302391
80DNA ligation (GO:0006266)3.14934326
81nucleosome disassembly (GO:0006337)3.13896436
82protein-DNA complex disassembly (GO:0032986)3.13896436
83RNA stabilization (GO:0043489)3.12326786
84mRNA stabilization (GO:0048255)3.12326786
85chromatin assembly or disassembly (GO:0006333)3.12277876
863-UTR-mediated mRNA stabilization (GO:0070935)3.12219550
87regulation of centrosome cycle (GO:0046605)3.11976451
88histone H2B ubiquitination (GO:0033523)3.11241080
89protein localization to chromosome (GO:0034502)3.08977355
90nucleobase biosynthetic process (GO:0046112)3.08695639
91translational elongation (GO:0006414)3.08608973
92positive regulation of DNA-dependent DNA replication (GO:2000105)3.05951813
93regulation of RNA export from nucleus (GO:0046831)3.05819475
94positive regulation of cell cycle checkpoint (GO:1901978)3.05693812
95purine nucleobase biosynthetic process (GO:0009113)3.04391041
96chromatin assembly (GO:0031497)3.03320434
97regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03303949
98ATP-dependent chromatin remodeling (GO:0043044)3.01741569
99definitive hemopoiesis (GO:0060216)3.00124072
100spindle assembly checkpoint (GO:0071173)2.98226334
101positive regulation of histone H3-K4 methylation (GO:0051571)2.98180621
102mitotic spindle checkpoint (GO:0071174)2.97738966
103protein complex localization (GO:0031503)2.96913688
104regulation of histone H3-K4 methylation (GO:0051569)2.96378616
105spindle checkpoint (GO:0031577)2.96308764
106regulation of chromosome segregation (GO:0051983)2.96302012
107translational initiation (GO:0006413)2.95582962
108formation of translation preinitiation complex (GO:0001731)2.95368103
109IMP metabolic process (GO:0046040)2.94821830
110regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94744995
111DNA packaging (GO:0006323)2.93671735
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93643949
113* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.92772268
114* mRNA splicing, via spliceosome (GO:0000398)2.92772268
115* RNA splicing, via transesterification reactions (GO:0000375)2.91807439
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90532334
117regulation of sister chromatid segregation (GO:0033045)2.88036769
118regulation of mitotic sister chromatid separation (GO:0010965)2.88036769
119regulation of mitotic sister chromatid segregation (GO:0033047)2.88036769
120histone exchange (GO:0043486)2.87436554
121* chromosome segregation (GO:0007059)2.86169014
122telomere maintenance (GO:0000723)2.86150802
123pre-miRNA processing (GO:0031054)2.85349700
124mitotic spindle assembly checkpoint (GO:0007094)2.84895292
125negative regulation of mRNA metabolic process (GO:1903312)2.84623407
126cellular protein complex disassembly (GO:0043624)2.84292286
127regulation of centriole replication (GO:0046599)2.82716545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.24666565
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.76630716
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.87915077
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.62641163
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.36255309
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83515384
7* E2F1_21310950_ChIP-Seq_MCF-7_Human2.56761518
8MYC_22102868_ChIP-Seq_BL_Human2.51845228
9AR_21909140_ChIP-Seq_LNCAP_Human2.50358277
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41260497
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40208132
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15436515
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15107625
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.11591923
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02378014
16E2F7_22180533_ChIP-Seq_HELA_Human11.7763233
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.96812053
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95763280
19XRN2_22483619_ChIP-Seq_HELA_Human1.95191899
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81777040
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80848957
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79731039
23CIITA_25753668_ChIP-Seq_RAJI_Human1.78774411
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.78295284
25ELK1_19687146_ChIP-ChIP_HELA_Human1.76086617
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73795881
27FOXP3_21729870_ChIP-Seq_TREG_Human1.70163583
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68516456
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66248001
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65197039
31CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.63281449
32VDR_21846776_ChIP-Seq_THP-1_Human1.60652427
33TTF2_22483619_ChIP-Seq_HELA_Human1.58485032
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58082171
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57632883
36VDR_23849224_ChIP-Seq_CD4+_Human1.57143259
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56633003
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56545925
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54336211
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51362908
41SCL_19346495_ChIP-Seq_HPC-7_Human1.44034709
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43428546
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41870901
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41729369
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40892732
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40678179
47CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38973086
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.37886351
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37734390
50* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35329946
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33303938
52KDM5A_27292631_Chip-Seq_BREAST_Human1.29632628
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28337855
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27005694
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25264286
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.25023244
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24700408
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20438642
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17559959
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17416459
61DCP1A_22483619_ChIP-Seq_HELA_Human1.16620872
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16174633
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15993061
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14183127
65MYB_26560356_Chip-Seq_TH2_Human1.14047861
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13380180
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12495531
68UTX_26944678_Chip-Seq_JUKART_Human1.11260516
69MYB_26560356_Chip-Seq_TH1_Human1.11243609
70* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11241546
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11173169
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10333771
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07961443
74GABP_19822575_ChIP-Seq_HepG2_Human1.07949955
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07548525
76TCF7_22412390_ChIP-Seq_EML_Mouse1.06491472
77SPI1_23547873_ChIP-Seq_NB4_Human1.05448572
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05410307
79MAF_26560356_Chip-Seq_TH1_Human1.02423231
80MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98312705
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95216559
82TFEB_21752829_ChIP-Seq_HELA_Human0.93494980
83* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91743462
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91680544
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91236203
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91137977
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90498329
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.89749796
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88949497
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88226376
91VDR_24763502_ChIP-Seq_THP-1_Human0.87830704
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.87661417
93THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87413863
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86973225
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86202979
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84652322
97FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84468655
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83855393
99CHD1_26751641_Chip-Seq_LNCaP_Human0.83270197
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82883443
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82579176
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82397280
103YY1_21170310_ChIP-Seq_MESCs_Mouse0.82011313
104STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.81800797
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81686648
106PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81473762
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.81126905
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.80721331
109FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.80639694
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80211187
111MYC_18940864_ChIP-ChIP_HL60_Human0.79884907
112HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.78337924
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77799405
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76683295
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76481542
116NOTCH1_21737748_ChIP-Seq_TLL_Human0.76435715
117NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76095278
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75925628
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75474886
120NCOR1_26117541_ChIP-Seq_K562_Human0.75297769
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74293021
122CLOCK_20551151_ChIP-Seq_293T_Human0.74261935
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.71894934
124ZNF263_19887448_ChIP-Seq_K562_Human0.71699793
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.70405223
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.67679384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability3.85112995
2MP0008057_abnormal_DNA_replication3.47870342
3MP0003693_abnormal_embryo_hatching3.42566338
4MP0002396_abnormal_hematopoietic_system3.36720386
5MP0003111_abnormal_nucleus_morphology3.32141053
6* MP0003077_abnormal_cell_cycle3.11666401
7MP0004957_abnormal_blastocyst_morpholog3.01028059
8MP0008007_abnormal_cellular_replicative2.53400925
9MP0004808_abnormal_hematopoietic_stem2.49194980
10MP0010352_gastrointestinal_tract_polyps2.45595421
11MP0008058_abnormal_DNA_repair2.28058250
12MP0010307_abnormal_tumor_latency1.97890910
13MP0003121_genomic_imprinting1.92263748
14MP0000350_abnormal_cell_proliferation1.88659898
15MP0001730_embryonic_growth_arrest1.83904817
16MP0008932_abnormal_embryonic_tissue1.79140845
17MP0003123_paternal_imprinting1.73462705
18MP0005076_abnormal_cell_differentiation1.63577716
19MP0004197_abnormal_fetal_growth/weight/1.59800844
20MP0006054_spinal_hemorrhage1.59559495
21MP0004233_abnormal_muscle_weight1.57870050
22MP0001672_abnormal_embryogenesis/_devel1.55840168
23MP0005380_embryogenesis_phenotype1.55840168
24MP0009278_abnormal_bone_marrow1.55832019
25MP0003763_abnormal_thymus_physiology1.52960803
26MP0003984_embryonic_growth_retardation1.52689875
27MP0010030_abnormal_orbit_morphology1.52673192
28MP0000490_abnormal_crypts_of1.51964851
29MP0001697_abnormal_embryo_size1.50837621
30MP0002088_abnormal_embryonic_growth/wei1.50722715
31MP0000703_abnormal_thymus_morphology1.48536147
32MP0003567_abnormal_fetal_cardiomyocyte1.48202145
33MP0009053_abnormal_anal_canal1.47302509
34MP0001346_abnormal_lacrimal_gland1.46772738
35MP0008877_abnormal_DNA_methylation1.44095252
36MP0003705_abnormal_hypodermis_morpholog1.40471511
37MP0002084_abnormal_developmental_patter1.40424730
38MP0002877_abnormal_melanocyte_morpholog1.40277541
39MP0009697_abnormal_copulation1.39769194
40MP0002085_abnormal_embryonic_tissue1.39159813
41MP0000537_abnormal_urethra_morphology1.38598216
42MP0002086_abnormal_extraembryonic_tissu1.38476241
43MP0004185_abnormal_adipocyte_glucose1.37616312
44MP0005397_hematopoietic_system_phenotyp1.34789672
45MP0001545_abnormal_hematopoietic_system1.34789672
46MP0009379_abnormal_foot_pigmentation1.33641457
47MP0002080_prenatal_lethality1.32865610
48MP0000569_abnormal_digit_pigmentation1.31079673
49MP0002398_abnormal_bone_marrow1.29302639
50MP0002166_altered_tumor_susceptibility1.26262126
51MP0003300_gastrointestinal_ulcer1.23898064
52MP0003787_abnormal_imprinting1.23366797
53MP0002019_abnormal_tumor_incidence1.18286748
54MP0003786_premature_aging1.14469194
55MP0003890_abnormal_embryonic-extraembry1.14031785
56MP0002722_abnormal_immune_system1.12242398
57* MP0000313_abnormal_cell_death1.10173868
58MP0005623_abnormal_meninges_morphology1.10170353
59MP0000428_abnormal_craniofacial_morphol1.04893785
60MP0002210_abnormal_sex_determination1.03695946
61MP0002938_white_spotting1.03484971
62MP0003943_abnormal_hepatobiliary_system1.03482230
63MP0003566_abnormal_cell_adhesion1.01170098
64MP0009703_decreased_birth_body0.99310492
65MP0003937_abnormal_limbs/digits/tail_de0.98851485
66MP0000465_gastrointestinal_hemorrhage0.97752147
67MP0000689_abnormal_spleen_morphology0.97702796
68MP0005023_abnormal_wound_healing0.97041219
69MP0002095_abnormal_skin_pigmentation0.96013218
70MP0002006_tumorigenesis0.95355801
71MP0000733_abnormal_muscle_development0.95272464
72MP0002249_abnormal_larynx_morphology0.95006252
73MP0005621_abnormal_cell_physiology0.94085649
74MP0001915_intracranial_hemorrhage0.93864444
75MP0003115_abnormal_respiratory_system0.93670837
76MP0003941_abnormal_skin_development0.92888216
77MP0003935_abnormal_craniofacial_develop0.92487231
78MP0002925_abnormal_cardiovascular_devel0.92462889
79MP0001661_extended_life_span0.92409818
80MP0000678_abnormal_parathyroid_gland0.90365776
81MP0002429_abnormal_blood_cell0.90076355
82MP0001929_abnormal_gametogenesis0.89018345
83MP0005409_darkened_coat_color0.87229864
84MP0001293_anophthalmia0.86814108
85MP0003861_abnormal_nervous_system0.86387789
86MP0002009_preneoplasia0.85047133
87MP0001145_abnormal_male_reproductive0.84694366
88MP0010368_abnormal_lymphatic_system0.84668474
89MP0005384_cellular_phenotype0.84474739
90MP0009333_abnormal_splenocyte_physiolog0.84356670
91MP0003385_abnormal_body_wall0.83651565
92MP0000716_abnormal_immune_system0.83328830
93MP0001800_abnormal_humoral_immune0.83040993
94MP0009672_abnormal_birth_weight0.82147088
95MP0000566_synostosis0.81280310
96MP0002092_abnormal_eye_morphology0.80722361
97MP0001849_ear_inflammation0.79936961
98MP0004264_abnormal_extraembryonic_tissu0.79816871
99MP0000432_abnormal_head_morphology0.79284843
100MP0003828_pulmonary_edema0.78960168
101MP0005187_abnormal_penis_morphology0.77510728
102MP0005501_abnormal_skin_physiology0.77485478
103MP0002114_abnormal_axial_skeleton0.76737065
104MP0001879_abnormal_lymphatic_vessel0.76428261
105MP0003303_peritoneal_inflammation0.75528148
106MP0005174_abnormal_tail_pigmentation0.75152669
107MP0009250_abnormal_appendicular_skeleto0.73914036
108MP0000358_abnormal_cell_content/0.73889367
109MP0002111_abnormal_tail_morphology0.73238070
110MP0001286_abnormal_eye_development0.71446320
111MP0003122_maternal_imprinting0.70707838
112MP0008438_abnormal_cutaneous_collagen0.70566014
113MP0002932_abnormal_joint_morphology0.70029023
114MP0002420_abnormal_adaptive_immunity0.69623779
115MP0010234_abnormal_vibrissa_follicle0.69472750
116MP0003315_abnormal_perineum_morphology0.69043216
117MP0000653_abnormal_sex_gland0.68195188
118MP0003755_abnormal_palate_morphology0.67846030
119MP0010630_abnormal_cardiac_muscle0.67790441
120MP0002697_abnormal_eye_size0.67471736
121MP0003718_maternal_effect0.67370775
122MP0002452_abnormal_antigen_presenting0.66548934
123MP0001819_abnormal_immune_cell0.66349884
124MP0003221_abnormal_cardiomyocyte_apopto0.65680581
125MP0003942_abnormal_urinary_system0.64684282
126MP0005666_abnormal_adipose_tissue0.64665011
127MP0002075_abnormal_coat/hair_pigmentati0.64432446
128MP0003699_abnormal_female_reproductive0.63791568
129MP0005408_hypopigmentation0.63193552
130MP0002160_abnormal_reproductive_system0.62992524
131MP0002970_abnormal_white_adipose0.61617822
132MP0002081_perinatal_lethality0.61428713
133MP0000579_abnormal_nail_morphology0.60489305
134MP0001186_pigmentation_phenotype0.59997369
135MP0002060_abnormal_skin_morphology0.57969584

Predicted human phenotypes

RankGene SetZ-score
1* Volvulus (HP:0002580)3.92809561
2Short 4th metacarpal (HP:0010044)3.76209715
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.76209715
4Chromsome breakage (HP:0040012)3.21309165
5Reticulocytopenia (HP:0001896)3.19351102
6Colon cancer (HP:0003003)3.09520176
7* Increased nuchal translucency (HP:0010880)3.04816769
8Medulloblastoma (HP:0002885)2.98195902
9High anterior hairline (HP:0009890)2.78720349
10Cortical dysplasia (HP:0002539)2.77735947
11Abnormality of the fingertips (HP:0001211)2.75824462
12Spinal cord lesions (HP:0100561)2.68940931
13Syringomyelia (HP:0003396)2.68940931
14Abnormality of the 4th metacarpal (HP:0010012)2.68666857
15Abnormality of chromosome stability (HP:0003220)2.65766926
16Abnormality of chromosome segregation (HP:0002916)2.62423778
17Long eyelashes (HP:0000527)2.61520415
18* Deviation of the thumb (HP:0009603)2.61448634
19Abnormality of cochlea (HP:0000375)2.61053305
20* Proximal placement of thumb (HP:0009623)2.58900262
21Myelodysplasia (HP:0002863)2.55359164
22Deep philtrum (HP:0002002)2.53135182
23Septate vagina (HP:0001153)2.47297508
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42886860
25Thrombocytosis (HP:0001894)2.42836035
26Acute myeloid leukemia (HP:0004808)2.41095444
27Abnormality of the calcaneus (HP:0008364)2.38826768
28Abnormal number of incisors (HP:0011064)2.36356852
29Ectopic kidney (HP:0000086)2.33262090
30Heterotopia (HP:0002282)2.31914214
31Hyperacusis (HP:0010780)2.28538879
32Absent radius (HP:0003974)2.25076104
33High pitched voice (HP:0001620)2.23376372
34Basal cell carcinoma (HP:0002671)2.23324061
35Abnormality of cells of the erythroid lineage (HP:0012130)2.21928782
36Ankyloglossia (HP:0010296)2.20949073
37Abnormal lung lobation (HP:0002101)2.19586841
38Selective tooth agenesis (HP:0001592)2.18397621
39Abnormality of the phalanges of the hallux (HP:0010057)2.15481743
40Insomnia (HP:0100785)2.13305295
41Abnormal number of erythroid precursors (HP:0012131)2.12770589
42Birth length less than 3rd percentile (HP:0003561)2.10898322
43Increased density of long bones (HP:0006392)2.10459613
44Rhabdomyosarcoma (HP:0002859)2.10085310
45Ependymoma (HP:0002888)2.08125935
46Duplication of thumb phalanx (HP:0009942)2.08075716
4711 pairs of ribs (HP:0000878)2.07632719
48Cutaneous melanoma (HP:0012056)2.06693986
49Sandal gap (HP:0001852)2.06473848
50Broad distal phalanx of finger (HP:0009836)2.06445495
51Acute lymphatic leukemia (HP:0006721)2.06423628
52Short thumb (HP:0009778)2.05880735
53* Obsessive-compulsive behavior (HP:0000722)2.05614420
54Progressive muscle weakness (HP:0003323)2.03860593
55Absent forearm bone (HP:0003953)2.03551034
56Aplasia involving forearm bones (HP:0009822)2.03551034
57* Cutis marmorata (HP:0000965)2.02501137
58Supernumerary ribs (HP:0005815)2.00777578
59* Atresia of the external auditory canal (HP:0000413)2.00064824
60Broad palm (HP:0001169)1.99944327
61Supernumerary bones of the axial skeleton (HP:0009144)1.99654432
62Progressive external ophthalmoplegia (HP:0000590)1.99432011
63Aplasia/Hypoplasia of the sternum (HP:0006714)1.98772310
64Abnormality of the distal phalanx of the thumb (HP:0009617)1.98106242
65Meckel diverticulum (HP:0002245)1.96078126
66Trigonocephaly (HP:0000243)1.95430030
67Small intestinal stenosis (HP:0012848)1.95404151
68Duodenal stenosis (HP:0100867)1.95404151
69Patellar aplasia (HP:0006443)1.95160288
70Abnormality of the preputium (HP:0100587)1.94906845
71Aplastic anemia (HP:0001915)1.94261960
72IgM deficiency (HP:0002850)1.94167394
73Renal duplication (HP:0000075)1.94062028
74* Choanal atresia (HP:0000453)1.93610581
75Multiple enchondromatosis (HP:0005701)1.91347919
76Dysmetric saccades (HP:0000641)1.91239376
77Overriding aorta (HP:0002623)1.90075108
78Ulnar bowing (HP:0003031)1.90009966
79Abnormal platelet volume (HP:0011876)1.89650832
80Asymmetry of the thorax (HP:0001555)1.89584002
81Embryonal neoplasm (HP:0002898)1.87754304
82Skin tags (HP:0010609)1.86844217
83Abnormality of the parietal bone (HP:0002696)1.86512915
84Microvesicular hepatic steatosis (HP:0001414)1.86254931
85Prominent nose (HP:0000448)1.85925319
86Skull defect (HP:0001362)1.84585677
87Abnormality of the ileum (HP:0001549)1.83742995
88Neoplasm of the oral cavity (HP:0100649)1.82811945
89Lymphoma (HP:0002665)1.82163916
90* Low anterior hairline (HP:0000294)1.81953378
91Limited elbow extension (HP:0001377)1.81798286
92Macroorchidism (HP:0000053)1.80707757
93Cellulitis (HP:0100658)1.80519605
94Amaurosis fugax (HP:0100576)1.80476837
95Overlapping toe (HP:0001845)1.79946913
96Increased mean platelet volume (HP:0011877)1.79726623
97Arteriovenous malformation (HP:0100026)1.79581221
98Horseshoe kidney (HP:0000085)1.79179789
99Shallow orbits (HP:0000586)1.78936276
100Abnormality of oral frenula (HP:0000190)1.78471002
101T lymphocytopenia (HP:0005403)1.78407286
102Neoplasm of striated muscle (HP:0009728)1.78099214
103Abnormal foot bone ossification (HP:0010675)1.78031430
104Sloping forehead (HP:0000340)1.77813328
105Nephroblastoma (Wilms tumor) (HP:0002667)1.77517881
106Facial hemangioma (HP:0000329)1.77508708
107Missing ribs (HP:0000921)1.76482663
108Embryonal renal neoplasm (HP:0011794)1.76240137
109Aplasia/Hypoplasia of the patella (HP:0006498)1.76232898
110Morphological abnormality of the inner ear (HP:0011390)1.76051525
111Long clavicles (HP:0000890)1.76036720
112Deep palmar crease (HP:0006191)1.74826419
113Abnormality of glycolysis (HP:0004366)1.74068492
114Pallor (HP:0000980)1.73075064
115Abnormality of the carotid arteries (HP:0005344)1.72923346
116Abnormality of B cell number (HP:0010975)1.72617658
117B lymphocytopenia (HP:0010976)1.72617658
118Abnormality of the labia minora (HP:0012880)1.72538170
119Orthostatic hypotension (HP:0001278)1.72339300
120Astrocytoma (HP:0009592)1.72307833
121Abnormality of the astrocytes (HP:0100707)1.72307833
122Patellar dislocation (HP:0002999)1.72093204
123Clubbing of toes (HP:0100760)1.71337752
124Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71329919
125Abnormality of the heme biosynthetic pathway (HP:0010472)1.70988454
126Abnormal gallbladder physiology (HP:0012438)1.69833610
127Cholecystitis (HP:0001082)1.69833610
128Optic nerve coloboma (HP:0000588)1.69782571
129Aplasia/Hypoplasia of the uvula (HP:0010293)1.69482223
130Lip pit (HP:0100267)1.69348420
131Urethral obstruction (HP:0000796)1.68999789
132Preauricular skin tag (HP:0000384)1.68210533
133Calcaneovalgus deformity (HP:0001848)1.68152435
134Duplicated collecting system (HP:0000081)1.68007023
135Absent frontal sinuses (HP:0002688)1.67072741
136Cafe-au-lait spot (HP:0000957)1.66984790
137Short middle phalanx of the 5th finger (HP:0004220)1.66974838
138Neonatal hypoglycemia (HP:0001998)1.66963651
139Glioma (HP:0009733)1.66955046
140Impulsivity (HP:0100710)1.66838398
141Hypopigmentation of the fundus (HP:0007894)1.66640522
142Abnormality of the peritoneum (HP:0002585)1.66066185
143Pseudobulbar signs (HP:0002200)1.65732183
144Elfin facies (HP:0004428)1.65595507
145Neoplasm of the colon (HP:0100273)1.65073443
146Single umbilical artery (HP:0001195)1.64820034
147Protrusio acetabuli (HP:0003179)1.64423382
148Abnormality of the duodenum (HP:0002246)1.63803285
149Subacute progressive viral hepatitis (HP:0006572)1.62831218
150Recurrent viral infections (HP:0004429)1.62577739
151Aplasia/Hypoplasia of the thymus (HP:0010515)1.61980133
152Squamous cell carcinoma (HP:0002860)1.61685270
153Neoplasm of the pancreas (HP:0002894)1.58714394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.28186569
2PNCK2.89819639
3MKNK12.72414071
4EEF2K2.67486188
5CDK122.66866745
6NEK22.65917524
7SMG12.62938871
8WEE12.54891433
9TSSK62.43235243
10CAMK1G2.27108433
11TGFBR12.25434345
12BUB12.24104419
13PASK2.13864962
14TTK2.10235504
15SRPK12.09616298
16ICK2.04862454
17MAP3K101.90592642
18RPS6KB21.83951918
19MAP4K11.83227913
20* ATR1.82619067
21AURKB1.80896766
22MKNK21.78303972
23STK101.76431219
24CDK61.65564849
25PLK31.63517666
26BRSK21.62762711
27CAMK1D1.59504540
28BRD41.58027481
29CDK41.54127936
30PLK11.52069792
31TAF11.47726955
32EIF2AK11.43274544
33STK41.42950453
34PBK1.42053033
35NEK11.41244314
36CDK71.40321201
37PKN21.35217018
38RPS6KA41.34548053
39CHEK21.33406380
40CLK11.32169655
41ACVR1B1.31503894
42CHEK11.30136887
43PLK41.25981867
44LRRK21.22487523
45MAP3K81.16751857
46* ATM1.15606652
47ALK1.12223069
48VRK21.06994829
49BTK1.06240034
50PAK41.00492471
51PRPF4B0.97376568
52CDK20.96359388
53DYRK30.95945288
54FGFR30.94541621
55CDK80.93882352
56MELK0.93607703
57CDK30.93398790
58IRAK30.90711390
59CCNB10.90703536
60PIM10.89976516
61TLK10.88080139
62TEC0.87087825
63CSF1R0.83901313
64VRK10.83778172
65MST1R0.83568078
66SCYL20.81462544
67TESK20.80871512
68CDK10.80801257
69STK30.80089162
70BRSK10.75124932
71KIT0.75046755
72EIF2AK20.71867540
73CDK90.71203744
74ZAK0.70637710
75MAP2K30.69643209
76TRPM70.69364742
77MTOR0.68872675
78TXK0.68539554
79JAK30.66333222
80TTN0.65098318
81PAK20.64900960
82NEK90.63714806
83CSNK2A20.61576139
84ITK0.61188341
85NME20.59454121
86SIK20.56384915
87FLT30.55562846
88NUAK10.55061127
89MET0.54711106
90PTK60.53747356
91ILK0.53656848
92KSR20.53616865
93FGFR40.53511202
94* PRKDC0.53164606
95ERBB30.53081216
96BRAF0.53029959
97RPS6KA50.52720089
98PDK20.51792273
99FGFR10.51723370
100CDK11A0.51287342
101MAPK110.51110062
102MAPK140.50692754
103WNK10.50075681
104FGFR20.49549305
105MAP3K130.48408196
106PDGFRA0.48219349
107CSNK2A10.47834729
108LATS10.47053060
109GSK3B0.47015605
110GRK60.46415823
111CDK150.45592901
112CSNK1E0.44638359
113AURKA0.44104276
114CDK180.43398895
115MAPK100.40833073
116AKT20.40377452
117MAPK10.38867689
118ERBB20.38713697
119CSNK1D0.38218905
120LCK0.37973973
121EIF2AK30.36757615
122YES10.36563356
123TGFBR20.36413955
124ZAP700.36368645
125KSR10.35901918
126AKT10.35817541
127CHUK0.35618900
128TRIB30.34983619
129LATS20.34916991
130MAP3K140.34904403
131RPS6KL10.34382991
132RPS6KC10.34382991
133MAP3K90.33901945
134CDK140.32890200
135RPS6KB10.32522124
136RAF10.30327675
137BMX0.29367598

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.88719953
2Mismatch repair_Homo sapiens_hsa034304.04123049
3Spliceosome_Homo sapiens_hsa030403.21762729
4* Cell cycle_Homo sapiens_hsa041103.08518324
5Base excision repair_Homo sapiens_hsa034102.93397537
6Homologous recombination_Homo sapiens_hsa034402.78527559
7Ribosome_Homo sapiens_hsa030102.69010652
8RNA transport_Homo sapiens_hsa030132.62799528
9Non-homologous end-joining_Homo sapiens_hsa034502.58909139
10Nucleotide excision repair_Homo sapiens_hsa034202.50298592
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29317021
12One carbon pool by folate_Homo sapiens_hsa006702.20316258
13mRNA surveillance pathway_Homo sapiens_hsa030152.08632480
14Fanconi anemia pathway_Homo sapiens_hsa034601.95446425
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85611996
16RNA degradation_Homo sapiens_hsa030181.81265278
17Biosynthesis of amino acids_Homo sapiens_hsa012301.49378992
18p53 signaling pathway_Homo sapiens_hsa041151.47054028
19MicroRNAs in cancer_Homo sapiens_hsa052061.45009584
20Primary immunodeficiency_Homo sapiens_hsa053401.39769563
21Viral carcinogenesis_Homo sapiens_hsa052031.36543661
22Pyrimidine metabolism_Homo sapiens_hsa002401.35127576
23Antigen processing and presentation_Homo sapiens_hsa046121.33915162
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33583601
25HTLV-I infection_Homo sapiens_hsa051661.30497300
26Herpes simplex infection_Homo sapiens_hsa051681.27804683
27Chronic myeloid leukemia_Homo sapiens_hsa052201.26755547
28Systemic lupus erythematosus_Homo sapiens_hsa053221.26441061
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24830060
30Small cell lung cancer_Homo sapiens_hsa052221.23702150
31Basal transcription factors_Homo sapiens_hsa030221.21508495
32Pentose phosphate pathway_Homo sapiens_hsa000301.19105000
33RNA polymerase_Homo sapiens_hsa030201.17758861
34Epstein-Barr virus infection_Homo sapiens_hsa051691.16145731
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15157853
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07886674
37Hepatitis B_Homo sapiens_hsa051611.02222279
38Colorectal cancer_Homo sapiens_hsa052101.01306847
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99611196
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98622665
41Carbon metabolism_Homo sapiens_hsa012000.97558317
42Thyroid cancer_Homo sapiens_hsa052160.95632620
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.92445532
44Selenocompound metabolism_Homo sapiens_hsa004500.91271482
45Lysine degradation_Homo sapiens_hsa003100.91090702
46Non-small cell lung cancer_Homo sapiens_hsa052230.88951423
47Pancreatic cancer_Homo sapiens_hsa052120.88841131
48Measles_Homo sapiens_hsa051620.87663287
49* Oocyte meiosis_Homo sapiens_hsa041140.87356760
50B cell receptor signaling pathway_Homo sapiens_hsa046620.86081118
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.85837843
52Prostate cancer_Homo sapiens_hsa052150.85195980
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84879552
54Basal cell carcinoma_Homo sapiens_hsa052170.82761534
55Viral myocarditis_Homo sapiens_hsa054160.82021087
56Hematopoietic cell lineage_Homo sapiens_hsa046400.80735051
57Proteasome_Homo sapiens_hsa030500.80636253
58Adherens junction_Homo sapiens_hsa045200.79568983
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.76948895
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76759449
61TGF-beta signaling pathway_Homo sapiens_hsa043500.75349570
62Pathways in cancer_Homo sapiens_hsa052000.74503162
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73935421
64Platelet activation_Homo sapiens_hsa046110.73640788
65Renal cell carcinoma_Homo sapiens_hsa052110.73323433
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72958356
67Pyruvate metabolism_Homo sapiens_hsa006200.72946399
68Notch signaling pathway_Homo sapiens_hsa043300.72905186
69Proteoglycans in cancer_Homo sapiens_hsa052050.71221232
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70485073
71Leishmaniasis_Homo sapiens_hsa051400.69278264
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67543424
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66851355
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.66770447
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66400745
76Apoptosis_Homo sapiens_hsa042100.65990509
77Shigellosis_Homo sapiens_hsa051310.64185582
78Hippo signaling pathway_Homo sapiens_hsa043900.62738832
79T cell receptor signaling pathway_Homo sapiens_hsa046600.62013110
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61377873
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60041305
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59578405
83Bladder cancer_Homo sapiens_hsa052190.58999929
84Vitamin B6 metabolism_Homo sapiens_hsa007500.58853298
85Purine metabolism_Homo sapiens_hsa002300.58144784
86Toxoplasmosis_Homo sapiens_hsa051450.57023836
87Acute myeloid leukemia_Homo sapiens_hsa052210.56268195
88Alcoholism_Homo sapiens_hsa050340.55258916
89Legionellosis_Homo sapiens_hsa051340.54813192
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54728267
91ErbB signaling pathway_Homo sapiens_hsa040120.53050462
92Endometrial cancer_Homo sapiens_hsa052130.52734559
93Focal adhesion_Homo sapiens_hsa045100.51440450
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51367646
95FoxO signaling pathway_Homo sapiens_hsa040680.49056379
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48837459
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48818501
98Wnt signaling pathway_Homo sapiens_hsa043100.48774709
99Influenza A_Homo sapiens_hsa051640.47900036
100ECM-receptor interaction_Homo sapiens_hsa045120.47827317
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47669282
102Melanoma_Homo sapiens_hsa052180.47626252
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.47549673
104Osteoclast differentiation_Homo sapiens_hsa043800.46893531
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46791856
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.45601302
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45568144
108AMPK signaling pathway_Homo sapiens_hsa041520.45423400
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45362935
110Insulin signaling pathway_Homo sapiens_hsa049100.45076556
111mTOR signaling pathway_Homo sapiens_hsa041500.45076137
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44274265
113HIF-1 signaling pathway_Homo sapiens_hsa040660.43984347
114Glioma_Homo sapiens_hsa052140.43007331
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42808965
116Inositol phosphate metabolism_Homo sapiens_hsa005620.40773355
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.39124800
118Fructose and mannose metabolism_Homo sapiens_hsa000510.38906638
119Hedgehog signaling pathway_Homo sapiens_hsa043400.37820812
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34934327
121Folate biosynthesis_Homo sapiens_hsa007900.34704416
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33833514
123Steroid biosynthesis_Homo sapiens_hsa001000.32465134
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.31321318
125TNF signaling pathway_Homo sapiens_hsa046680.29796093
126N-Glycan biosynthesis_Homo sapiens_hsa005100.29419039
127Glucagon signaling pathway_Homo sapiens_hsa049220.28370990
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28163678
129Choline metabolism in cancer_Homo sapiens_hsa052310.26656610
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22124786
131VEGF signaling pathway_Homo sapiens_hsa043700.20412840
132Prolactin signaling pathway_Homo sapiens_hsa049170.18716363

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