SMARCAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.00864221
2nuclear pore organization (GO:0006999)4.94591916
3regulation of helicase activity (GO:0051095)4.36394209
4regulation of histone H3-K9 methylation (GO:0051570)4.30587279
5kinetochore organization (GO:0051383)4.28431901
6DNA topological change (GO:0006265)4.23729600
7pre-miRNA processing (GO:0031054)4.23111583
8DNA ligation (GO:0006266)4.00538803
9DNA replication-dependent nucleosome organization (GO:0034723)3.99428700
10DNA replication-dependent nucleosome assembly (GO:0006335)3.99428700
11* DNA double-strand break processing (GO:0000729)3.99101524
12kinetochore assembly (GO:0051382)3.96373512
13DNA unwinding involved in DNA replication (GO:0006268)3.92816407
14protein localization to kinetochore (GO:0034501)3.89828572
15mitotic metaphase plate congression (GO:0007080)3.86288922
16DNA replication initiation (GO:0006270)3.84843966
17pore complex assembly (GO:0046931)3.83757636
18mitotic nuclear envelope disassembly (GO:0007077)3.78304398
19chromatin remodeling at centromere (GO:0031055)3.77376431
20non-recombinational repair (GO:0000726)3.75436079
21double-strand break repair via nonhomologous end joining (GO:0006303)3.75436079
22regulation of nuclear cell cycle DNA replication (GO:0033262)3.72889233
23negative regulation of histone methylation (GO:0031061)3.72636867
24mitotic sister chromatid cohesion (GO:0007064)3.70723532
25CENP-A containing nucleosome assembly (GO:0034080)3.69790851
26intra-S DNA damage checkpoint (GO:0031573)3.69552672
27regulation of gene silencing by RNA (GO:0060966)3.62287827
28regulation of posttranscriptional gene silencing (GO:0060147)3.62287827
29regulation of gene silencing by miRNA (GO:0060964)3.62287827
30establishment of integrated proviral latency (GO:0075713)3.61481773
31paraxial mesoderm development (GO:0048339)3.58360325
32metaphase plate congression (GO:0051310)3.56774259
33protein K6-linked ubiquitination (GO:0085020)3.56110377
34somatic diversification of immune receptors via somatic mutation (GO:0002566)3.54956015
35somatic hypermutation of immunoglobulin genes (GO:0016446)3.54956015
36DNA replication-independent nucleosome assembly (GO:0006336)3.54036270
37DNA replication-independent nucleosome organization (GO:0034724)3.54036270
38membrane disassembly (GO:0030397)3.51553689
39nuclear envelope disassembly (GO:0051081)3.51553689
40replication fork processing (GO:0031297)3.50123490
41DNA strand elongation involved in DNA replication (GO:0006271)3.47324754
42DNA replication checkpoint (GO:0000076)3.45921574
43ribosome assembly (GO:0042255)3.44938344
44DNA geometric change (GO:0032392)3.44465498
45DNA duplex unwinding (GO:0032508)3.44382627
46microtubule depolymerization (GO:0007019)3.43976379
47regulation of telomere maintenance via telomerase (GO:0032210)3.43663010
48sister chromatid segregation (GO:0000819)3.34320789
49negative regulation of DNA-dependent DNA replication (GO:2000104)3.33916577
50spindle checkpoint (GO:0031577)3.33603020
51DNA strand elongation (GO:0022616)3.31212434
52negative regulation of DNA recombination (GO:0045910)3.30825643
53positive regulation of chromosome segregation (GO:0051984)3.29444517
54spindle assembly checkpoint (GO:0071173)3.28672344
55telomere maintenance via semi-conservative replication (GO:0032201)3.25348222
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25057500
57regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.24217331
58negative regulation of chromosome segregation (GO:0051985)3.23710789
59negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22355462
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22355462
61negative regulation of sister chromatid segregation (GO:0033046)3.22355462
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.22355462
63histone exchange (GO:0043486)3.22229868
64mitotic spindle checkpoint (GO:0071174)3.22052324
65mitotic recombination (GO:0006312)3.21514670
66regulation of mitotic metaphase/anaphase transition (GO:0030071)3.21353553
67protein localization to chromosome, centromeric region (GO:0071459)3.21211762
68establishment of chromosome localization (GO:0051303)3.20806580
69meiotic chromosome segregation (GO:0045132)3.20664117
70mitotic chromosome condensation (GO:0007076)3.20642291
71positive regulation of mitotic sister chromatid separation (GO:1901970)3.20486968
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.20486968
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.20486968
74mitotic spindle assembly checkpoint (GO:0007094)3.20439160
75IMP biosynthetic process (GO:0006188)3.20028933
76regulation of spindle organization (GO:0090224)3.19193711
77mitotic sister chromatid segregation (GO:0000070)3.16267989
78regulation of centriole replication (GO:0046599)3.15183670
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13135667
80regulation of chromosome segregation (GO:0051983)3.12814484
81chromatin assembly or disassembly (GO:0006333)3.12657491
82regulation of centrosome cycle (GO:0046605)3.11792608
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11691084
84mismatch repair (GO:0006298)3.11274030
85nucleobase biosynthetic process (GO:0046112)3.09654677
86regulation of sister chromatid segregation (GO:0033045)3.09362832
87regulation of mitotic sister chromatid separation (GO:0010965)3.09362832
88regulation of mitotic sister chromatid segregation (GO:0033047)3.09362832
89telomere maintenance via recombination (GO:0000722)3.08101201
90regulation of histone H3-K27 methylation (GO:0061085)3.06377946
91regulation of mitotic spindle organization (GO:0060236)3.06038572
92regulation of sister chromatid cohesion (GO:0007063)3.05617710
93histone H2A monoubiquitination (GO:0035518)3.05256892
94resolution of meiotic recombination intermediates (GO:0000712)3.04715874
95regulation of RNA export from nucleus (GO:0046831)2.98637974
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98449602
97translesion synthesis (GO:0019985)2.97976180
98chromatin assembly (GO:0031497)2.96516794
99regulation of DNA endoreduplication (GO:0032875)2.93439562
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.93286225
101purine nucleobase biosynthetic process (GO:0009113)2.92500677
102regulation of mitotic spindle checkpoint (GO:1903504)2.90484289
103regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90484289
104regulation of gene silencing (GO:0060968)2.89141004
105postreplication repair (GO:0006301)2.87171191
106telomere maintenance via telomere lengthening (GO:0010833)2.86717981
107formation of translation preinitiation complex (GO:0001731)2.86566397
108mitotic G2/M transition checkpoint (GO:0044818)2.85959047
109positive regulation of histone methylation (GO:0031062)2.85101001
110regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84773801
111folic acid-containing compound biosynthetic process (GO:0009396)2.84196460
112* ATP-dependent chromatin remodeling (GO:0043044)2.83339236
113centriole replication (GO:0007099)2.82697977
114attachment of spindle microtubules to kinetochore (GO:0008608)2.82670026
115chromosome segregation (GO:0007059)2.80242039
116regulation of centrosome duplication (GO:0010824)2.79642997
117histone H2A acetylation (GO:0043968)2.78470837
118presynaptic membrane assembly (GO:0097105)2.75834004
119sister chromatid cohesion (GO:0007062)2.74911955
120protein localization to chromosome (GO:0034502)2.73339530
121regulation of development, heterochronic (GO:0040034)2.72485352
122response to X-ray (GO:0010165)2.66301609
123microtubule polymerization or depolymerization (GO:0031109)2.61414462
124mitotic spindle organization (GO:0007052)2.58472072
125limb bud formation (GO:0060174)2.56773579
126V(D)J recombination (GO:0033151)2.55560828
127establishment of viral latency (GO:0019043)2.54323157
128negative regulation of DNA repair (GO:0045738)2.53211886
129intraciliary transport (GO:0042073)2.52830841
130olfactory bulb development (GO:0021772)2.51687970
131DNA damage response, detection of DNA damage (GO:0042769)2.50268048
132regulation of timing of cell differentiation (GO:0048505)2.49654419
133neural tube formation (GO:0001841)2.49510416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.02174742
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.45195015
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.59493791
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.50744585
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27760045
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.04795402
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71052881
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.57344392
9* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57210981
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48331337
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47421671
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.45349827
13FUS_26573619_Chip-Seq_HEK293_Human2.44737793
14MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.43425390
15IGF1R_20145208_ChIP-Seq_DFB_Human2.41534529
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.39172909
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39047742
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.38828119
19SOX2_18555785_ChIP-Seq_MESCs_Mouse2.32039429
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28877504
21* KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.27988853
22* KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.27988853
23* KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.27988853
24TAF15_26573619_Chip-Seq_HEK293_Human2.27716606
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21864568
26ZNF274_21170338_ChIP-Seq_K562_Hela2.16147808
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13792779
28NANOG_18555785_ChIP-Seq_MESCs_Mouse2.13639447
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05078702
30E2F7_22180533_ChIP-Seq_HELA_Human10.6884984
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93949043
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93907815
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.91625092
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90831406
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89650186
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87918938
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87523649
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85879193
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85805181
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85506099
41GBX2_23144817_ChIP-Seq_PC3_Human1.85281919
42AR_21909140_ChIP-Seq_LNCAP_Human1.77598485
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.77589537
44P300_19829295_ChIP-Seq_ESCs_Human1.75650845
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.74966318
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73736856
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73079322
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71459026
49* ELK1_19687146_ChIP-ChIP_HELA_Human1.70259593
50* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.68375703
51XRN2_22483619_ChIP-Seq_HELA_Human1.68366681
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.67613043
53* EST1_17652178_ChIP-ChIP_JURKAT_Human1.66680004
54* VDR_23849224_ChIP-Seq_CD4+_Human1.65077102
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.61805787
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60049297
57* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59446502
58SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.59225889
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57701246
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57525601
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53768162
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50554450
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50278665
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.48425731
65* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46578536
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46513448
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45184549
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45150951
69CIITA_25753668_ChIP-Seq_RAJI_Human1.40084292
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39524298
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38312130
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38272840
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37807585
74* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35509028
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35474556
76* FOXP3_21729870_ChIP-Seq_TREG_Human1.35419116
77* GABP_17652178_ChIP-ChIP_JURKAT_Human1.33350744
78* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32712075
79TTF2_22483619_ChIP-Seq_HELA_Human1.31417170
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30927422
81NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.29957575
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29685917
83MYC_18940864_ChIP-ChIP_HL60_Human1.28039938
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.26725695
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25987058
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.24201109
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.21801727
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20691762
89SMAD4_21799915_ChIP-Seq_A2780_Human1.20690671
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20310020
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18953065
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18224752
93* SOX2_16153702_ChIP-ChIP_HESCs_Human1.17697809
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16816010
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15962772
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15823021
97SOX9_26525672_Chip-Seq_HEART_Mouse1.15326230
98VDR_22108803_ChIP-Seq_LS180_Human1.15297101
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14803850
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14134847
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.13998908
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13020620
103* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12783205
104MYC_22102868_ChIP-Seq_BL_Human1.11945576
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11944058
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11894669
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11761735
108* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11138507
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09841655
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09808849
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.08310025
112STAT3_23295773_ChIP-Seq_U87_Human1.07246959
113NANOG_21062744_ChIP-ChIP_HESCs_Human1.07221188
114RNF2_27304074_Chip-Seq_NSC_Mouse1.06830562
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05301856
116KDM5A_27292631_Chip-Seq_BREAST_Human1.04894738
117* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04398322
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03959251
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02988692
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02988692
121NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02898248
122* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02251674
123ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01667206
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01349874
125ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01027464
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01000542
127* NANOG_16153702_ChIP-ChIP_HESCs_Human1.00757585
128TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00673907
129TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99778847
130* GABP_19822575_ChIP-Seq_HepG2_Human0.99701573
131GATA1_26923725_Chip-Seq_HPCs_Mouse0.98873656
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98817195
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98657957
134CBP_20019798_ChIP-Seq_JUKART_Human0.98657957
135POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98497548
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97466301
137* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96583114
138DCP1A_22483619_ChIP-Seq_HELA_Human0.96432199
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96388664
140TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96174217
141ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95957558
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.95924449
143IRF1_19129219_ChIP-ChIP_H3396_Human0.95071740
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94695345
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94604516
146FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94519952
147TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94020282
148CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93667594
149NOTCH1_21737748_ChIP-Seq_TLL_Human0.91694054
150CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90797446
151YY1_21170310_ChIP-Seq_MESCs_Mouse0.90325314
152EWS_26573619_Chip-Seq_HEK293_Human0.88614221
153PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86090593
154* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84996640
155E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84318246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.50025783
2MP0010094_abnormal_chromosome_stability4.05523790
3MP0003693_abnormal_embryo_hatching3.68756245
4MP0003111_abnormal_nucleus_morphology3.68591663
5MP0003077_abnormal_cell_cycle3.36633749
6MP0004957_abnormal_blastocyst_morpholog3.23955996
7MP0008058_abnormal_DNA_repair3.10782570
8MP0008007_abnormal_cellular_replicative2.61591966
9MP0006292_abnormal_olfactory_placode2.34527189
10MP0003136_yellow_coat_color2.23722853
11MP0003941_abnormal_skin_development2.22542259
12MP0008932_abnormal_embryonic_tissue2.22466538
13MP0010352_gastrointestinal_tract_polyps2.09710734
14MP0010307_abnormal_tumor_latency2.04031629
15MP0003123_paternal_imprinting2.01961864
16MP0000350_abnormal_cell_proliferation1.97224602
17MP0009697_abnormal_copulation1.95875243
18MP0001293_anophthalmia1.94891312
19MP0003121_genomic_imprinting1.94833512
20MP0003890_abnormal_embryonic-extraembry1.84707231
21MP0000778_abnormal_nervous_system1.82853775
22MP0001730_embryonic_growth_arrest1.78668040
23MP0010030_abnormal_orbit_morphology1.74892942
24MP0005499_abnormal_olfactory_system1.74718262
25MP0005394_taste/olfaction_phenotype1.74718262
26MP0002084_abnormal_developmental_patter1.74244438
27MP0002085_abnormal_embryonic_tissue1.72353264
28MP0002396_abnormal_hematopoietic_system1.70234880
29MP0001672_abnormal_embryogenesis/_devel1.65591207
30MP0005380_embryogenesis_phenotype1.65591207
31MP0001529_abnormal_vocalization1.58562828
32MP0003937_abnormal_limbs/digits/tail_de1.58318913
33MP0000537_abnormal_urethra_morphology1.58093451
34MP0002234_abnormal_pharynx_morphology1.56608404
35MP0002086_abnormal_extraembryonic_tissu1.54515578
36* MP0004197_abnormal_fetal_growth/weight/1.53330375
37MP0001697_abnormal_embryo_size1.52983453
38MP0005076_abnormal_cell_differentiation1.49495167
39MP0005248_abnormal_Harderian_gland1.49351179
40MP0004133_heterotaxia1.48968372
41MP0008877_abnormal_DNA_methylation1.47811670
42MP0003880_abnormal_central_pattern1.47404826
43MP0003315_abnormal_perineum_morphology1.43750120
44MP0003984_embryonic_growth_retardation1.39907129
45MP0003786_premature_aging1.39792235
46MP0002088_abnormal_embryonic_growth/wei1.38440902
47MP0002938_white_spotting1.35174876
48MP0001299_abnormal_eye_distance/1.33235300
49MP0002653_abnormal_ependyma_morphology1.31916071
50MP0003122_maternal_imprinting1.31675201
51MP0006072_abnormal_retinal_apoptosis1.29853499
52MP0003119_abnormal_digestive_system1.28824802
53MP0004808_abnormal_hematopoietic_stem1.28700503
54MP0005367_renal/urinary_system_phenotyp1.27947985
55MP0000516_abnormal_urinary_system1.27947985
56MP0002277_abnormal_respiratory_mucosa1.27111700
57MP0002009_preneoplasia1.25806059
58MP0002080_prenatal_lethality1.25330472
59MP0005187_abnormal_penis_morphology1.24873692
60MP0001177_atelectasis1.24195598
61MP0003567_abnormal_fetal_cardiomyocyte1.23444274
62MP0000371_diluted_coat_color1.21876730
63MP0000490_abnormal_crypts_of1.20745355
64MP0001286_abnormal_eye_development1.19664044
65MP0000428_abnormal_craniofacial_morphol1.17528880
66MP0009053_abnormal_anal_canal1.17270255
67MP0002249_abnormal_larynx_morphology1.12070552
68MP0000647_abnormal_sebaceous_gland1.11232525
69MP0003935_abnormal_craniofacial_develop1.10617030
70MP0005391_vision/eye_phenotype1.10342727
71MP0003755_abnormal_palate_morphology1.10195679
72MP0002210_abnormal_sex_determination1.10173261
73MP0002075_abnormal_coat/hair_pigmentati1.09921827
74MP0000383_abnormal_hair_follicle1.08686901
75MP0000432_abnormal_head_morphology1.08257251
76MP0002092_abnormal_eye_morphology1.08217900
77MP0000313_abnormal_cell_death1.06936887
78* MP0009703_decreased_birth_body1.06238473
79MP0005253_abnormal_eye_physiology1.04517106
80MP0002697_abnormal_eye_size1.04041245
81MP0003718_maternal_effect1.03811558
82MP0002111_abnormal_tail_morphology1.02840515
83MP0002751_abnormal_autonomic_nervous1.01378652
84MP0003787_abnormal_imprinting1.00873295
85MP0001186_pigmentation_phenotype0.99851066
86MP0000631_abnormal_neuroendocrine_gland0.99331259
87MP0003943_abnormal_hepatobiliary_system0.98967002
88MP0000569_abnormal_digit_pigmentation0.97856509
89MP0009672_abnormal_birth_weight0.95832508
90* MP0002081_perinatal_lethality0.95318952
91MP0002184_abnormal_innervation0.95308096
92MP0001145_abnormal_male_reproductive0.94600790
93MP0000049_abnormal_middle_ear0.94525787
94MP0002233_abnormal_nose_morphology0.94279611
95MP0002098_abnormal_vibrissa_morphology0.93716726
96MP0003861_abnormal_nervous_system0.93261046
97MP0003221_abnormal_cardiomyocyte_apopto0.92914190
98MP0010678_abnormal_skin_adnexa0.92669450
99MP0000733_abnormal_muscle_development0.92470506
100MP0002019_abnormal_tumor_incidence0.90917896
101MP0001984_abnormal_olfaction0.89602594
102MP0002282_abnormal_trachea_morphology0.87498706
103MP0002095_abnormal_skin_pigmentation0.86888477
104MP0002177_abnormal_outer_ear0.84246708
105MP0005171_absent_coat_pigmentation0.83962273
106MP0008789_abnormal_olfactory_epithelium0.83842298
107MP0000566_synostosis0.83796149
108MP0003385_abnormal_body_wall0.82921967
109MP0000427_abnormal_hair_cycle0.81216432
110MP0002152_abnormal_brain_morphology0.81142248
111MP0009250_abnormal_appendicular_skeleto0.79850509
112MP0000653_abnormal_sex_gland0.79172866
113MP0003942_abnormal_urinary_system0.78969383
114MP0001849_ear_inflammation0.78002413
115MP0000955_abnormal_spinal_cord0.76585630
116MP0006276_abnormal_autonomic_nervous0.76109023
117MP0000762_abnormal_tongue_morphology0.75043133
118MP0002116_abnormal_craniofacial_bone0.75012010
119MP0003283_abnormal_digestive_organ0.74898072
120MP0010234_abnormal_vibrissa_follicle0.73432228
121MP0000703_abnormal_thymus_morphology0.73416872
122MP0004811_abnormal_neuron_physiology0.73028135
123MP0003938_abnormal_ear_development0.72675016
124MP0001188_hyperpigmentation0.72657370
125* MP0001929_abnormal_gametogenesis0.72413314
126MP0005174_abnormal_tail_pigmentation0.72310068
127MP0002102_abnormal_ear_morphology0.72046231
128MP0005389_reproductive_system_phenotype0.71954804
129MP0002752_abnormal_somatic_nervous0.70970667
130MP0001119_abnormal_female_reproductive0.70794365
131MP0002925_abnormal_cardiovascular_devel0.69546139
132MP0003115_abnormal_respiratory_system0.69467420

Predicted human phenotypes

RankGene SetZ-score
1Medulloblastoma (HP:0002885)4.55101685
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.27246888
3Chromsome breakage (HP:0040012)4.25982115
4Cortical dysplasia (HP:0002539)3.68134686
5Ependymoma (HP:0002888)3.62089119
6Rhabdomyosarcoma (HP:0002859)3.50920909
7Birth length less than 3rd percentile (HP:0003561)3.47693490
8Abnormality of chromosome stability (HP:0003220)3.36309515
9Abnormality of the labia minora (HP:0012880)3.34015225
10Meckel diverticulum (HP:0002245)3.29013407
11Breast hypoplasia (HP:0003187)3.21971359
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.20191034
13Abnormality of the ileum (HP:0001549)3.13670723
14Colon cancer (HP:0003003)3.13150382
15Supernumerary spleens (HP:0009799)2.99815573
16Abnormality of the preputium (HP:0100587)2.95451654
17Volvulus (HP:0002580)2.92449494
18Neoplasm of the oral cavity (HP:0100649)2.91079714
19Glioma (HP:0009733)2.85314332
20Agnosia (HP:0010524)2.83085953
21Astrocytoma (HP:0009592)2.82217996
22Abnormality of the astrocytes (HP:0100707)2.82217996
23Neoplasm of striated muscle (HP:0009728)2.68143180
24Ectopic kidney (HP:0000086)2.65209071
25Hepatoblastoma (HP:0002884)2.61810464
26Duodenal stenosis (HP:0100867)2.60667397
27Small intestinal stenosis (HP:0012848)2.60667397
28Absent radius (HP:0003974)2.56806994
29Patellar aplasia (HP:0006443)2.56379297
30Impulsivity (HP:0100710)2.54621398
31Myelodysplasia (HP:0002863)2.54110638
32Abnormality of the carotid arteries (HP:0005344)2.49253386
33Drooling (HP:0002307)2.47700158
34Abnormality of abdominal situs (HP:0011620)2.46780851
35Abdominal situs inversus (HP:0003363)2.46780851
36Aplasia/Hypoplasia of the patella (HP:0006498)2.41920913
37Aplasia involving forearm bones (HP:0009822)2.41324340
38Absent forearm bone (HP:0003953)2.41324340
39High anterior hairline (HP:0009890)2.39325924
40Selective tooth agenesis (HP:0001592)2.35485940
41Supernumerary ribs (HP:0005815)2.31713047
42Abnormal number of incisors (HP:0011064)2.31469428
43Abnormality of the duodenum (HP:0002246)2.30835246
44Increased nuchal translucency (HP:0010880)2.30245892
45Esophageal atresia (HP:0002032)2.29571067
46Amaurosis fugax (HP:0100576)2.29442027
47Supernumerary bones of the axial skeleton (HP:0009144)2.28907034
48Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.27397186
49Short 4th metacarpal (HP:0010044)2.27397186
50Nephroblastoma (Wilms tumor) (HP:0002667)2.25541803
51Aplasia/Hypoplasia of the sternum (HP:0006714)2.24880209
52Reticulocytopenia (HP:0001896)2.24278034
53Missing ribs (HP:0000921)2.21640859
54Bifid tongue (HP:0010297)2.21630970
55Aqueductal stenosis (HP:0002410)2.19389793
56Excessive salivation (HP:0003781)2.17315471
57Abnormal lung lobation (HP:0002101)2.15224524
58Proximal placement of thumb (HP:0009623)2.14256570
59Embryonal renal neoplasm (HP:0011794)2.13858750
60Shawl scrotum (HP:0000049)2.12919425
61Neoplasm of the adrenal cortex (HP:0100641)2.12449301
62Abnormality of the renal collecting system (HP:0004742)2.12108092
63Duplicated collecting system (HP:0000081)2.10537412
64Clubbing of toes (HP:0100760)2.09449457
65Deviation of the thumb (HP:0009603)2.07815901
66Absent thumb (HP:0009777)2.07151178
67Sloping forehead (HP:0000340)2.05834176
68Gastrointestinal atresia (HP:0002589)2.04640731
69Rib fusion (HP:0000902)2.02686589
70Renal hypoplasia (HP:0000089)2.02412992
7111 pairs of ribs (HP:0000878)2.02238058
72Intestinal atresia (HP:0011100)2.02057141
73Aplasia/hypoplasia of the humerus (HP:0006507)2.01886327
74Tracheoesophageal fistula (HP:0002575)2.01110458
75Genital tract atresia (HP:0001827)2.00482305
76Gastrointestinal carcinoma (HP:0002672)1.98757608
77Malignant gastrointestinal tract tumors (HP:0006749)1.98757608
78Short thumb (HP:0009778)1.98551538
79Biliary tract neoplasm (HP:0100574)1.97843184
80Abnormality of DNA repair (HP:0003254)1.97525993
81Atresia of the external auditory canal (HP:0000413)1.95578064
82Abnormality of the antihelix (HP:0009738)1.94945379
83Vaginal atresia (HP:0000148)1.94305953
84Overlapping toe (HP:0001845)1.93887737
85Papillary thyroid carcinoma (HP:0002895)1.92709144
86Cystic hygroma (HP:0000476)1.92497421
87Septo-optic dysplasia (HP:0100842)1.92492083
88Skull defect (HP:0001362)1.92251976
89Triphalangeal thumb (HP:0001199)1.89222091
90Short humerus (HP:0005792)1.88384368
91Bone marrow hypocellularity (HP:0005528)1.87555910
92Long clavicles (HP:0000890)1.85081924
93Congenital primary aphakia (HP:0007707)1.84129054
94Basal cell carcinoma (HP:0002671)1.83964916
95Curly hair (HP:0002212)1.83297673
96Micropenis (HP:0000054)1.82385786
97Gonadotropin excess (HP:0000837)1.81882848
98Abnormality of the septum pellucidum (HP:0007375)1.81626980
99Preaxial hand polydactyly (HP:0001177)1.81300642
100Gait imbalance (HP:0002141)1.78855388
101Acute lymphatic leukemia (HP:0006721)1.78811753
102Neoplasm of the pancreas (HP:0002894)1.78165346
103Facial hemangioma (HP:0000329)1.77589238
104Medial flaring of the eyebrow (HP:0010747)1.77241875
105Anal stenosis (HP:0002025)1.76596743
106Deep philtrum (HP:0002002)1.76393370
107Oligodactyly (hands) (HP:0001180)1.75119206
108Nephrogenic diabetes insipidus (HP:0009806)1.72901401
109Aplastic anemia (HP:0001915)1.72325245
110Thyroid carcinoma (HP:0002890)1.70599325
111Cafe-au-lait spot (HP:0000957)1.70293190
112Premature graying of hair (HP:0002216)1.70042477
113Broad foot (HP:0001769)1.69341765
114Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68745965
115Anophthalmia (HP:0000528)1.68705936
116Median cleft lip (HP:0000161)1.67932751
117Cutaneous finger syndactyly (HP:0010554)1.66699652
118Dandy-Walker malformation (HP:0001305)1.65809337
119Neoplasm of the small intestine (HP:0100833)1.65696406
120Chronic hepatic failure (HP:0100626)1.64945603
121Oligodactyly (HP:0012165)1.64781322
122Abnormality of the metopic suture (HP:0005556)1.64380760
123Hemivertebrae (HP:0002937)1.64015841
124Facial cleft (HP:0002006)1.63262540
125Postaxial hand polydactyly (HP:0001162)1.63002382
126Absent septum pellucidum (HP:0001331)1.62326981
127Arteriovenous malformation (HP:0100026)1.61783163
128Renal duplication (HP:0000075)1.61556705
129Abnormality of the diencephalon (HP:0010662)1.61189743
130Embryonal neoplasm (HP:0002898)1.61115124
131Labial hypoplasia (HP:0000066)1.61036262
132Postaxial foot polydactyly (HP:0001830)1.60610316
133Abnormality of the anterior horn cell (HP:0006802)1.60481679
134Degeneration of anterior horn cells (HP:0002398)1.60481679
135Abnormal hair whorl (HP:0010721)1.60007725
136Absent eyebrow (HP:0002223)1.59926244
137Lip pit (HP:0100267)1.59809308
138Hypospadias (HP:0000047)1.59508846
139True hermaphroditism (HP:0010459)1.58922759
140Gastroesophageal reflux (HP:0002020)1.58304250
141Neoplasm of the respiratory system (HP:0100606)1.58243436
142Cutaneous syndactyly (HP:0012725)1.58049914
143Spastic diplegia (HP:0001264)1.57776329
144Long eyelashes (HP:0000527)1.57747789
145Scrotal hypoplasia (HP:0000046)1.56876864
146Neoplasm of the colon (HP:0100273)1.56364439
147Astigmatism (HP:0000483)1.55428680
148Nephronophthisis (HP:0000090)1.54567998
149Poor coordination (HP:0002370)1.54046896
150Narrow forehead (HP:0000341)1.54036541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.77038924
2SRPK13.57643138
3WEE13.48950665
4CDK193.38968842
5CDK123.26833672
6STK163.19467473
7TRIM283.12552482
8TLK12.65498800
9MKNK22.62480562
10ZAK2.48522258
11MKNK12.47106181
12TTK2.33609800
13EPHA22.33418568
14BUB12.23454178
15MAP3K42.23341315
16NEK22.15864961
17BRD42.12766807
18PLK42.06448276
19CASK2.02808724
20MAP3K102.02067642
21LATS11.95342927
22PLK11.93340690
23PLK31.89118827
24DYRK31.88742962
25CHEK21.85067151
26PASK1.84543545
27ACVR1B1.84202000
28ATR1.80603800
29BRSK21.80450453
30RPS6KB21.74303104
31TSSK61.71273220
32VRK11.68050713
33TNIK1.66866993
34STK41.65534574
35CDK71.63995174
36CDK41.53082504
37AURKB1.50219729
38AKT31.49802004
39PBK1.42867849
40MAP4K21.42431542
41MAPK131.38478222
42PNCK1.38134370
43CHEK11.35738054
44BMPR1B1.35432472
45ATM1.33541082
46MARK11.31441041
47PLK21.27280485
48TAF11.23284786
49EPHA41.15356488
50MAP2K71.13078104
51CDK61.10995426
52ERBB31.05489266
53STK31.02868910
54CSNK1G21.02672013
55* CDK20.98072434
56EIF2AK20.96124060
57SIK30.90811945
58TGFBR10.88224917
59YES10.87263608
60PIM10.85989665
61NEK10.84670144
62EIF2AK30.83816053
63FRK0.83579117
64AURKA0.83231267
65ALK0.78774353
66* CDK10.77410609
67NUAK10.76984505
68MST40.76011655
69EEF2K0.75930621
70PRKD30.75401679
71EIF2AK10.73644278
72MELK0.72440606
73MAP3K80.71547632
74FGFR20.71216904
75CAMK1G0.71050654
76MTOR0.70301660
77PAK40.69622648
78STK38L0.69129810
79BRSK10.68784410
80RPS6KA40.67547064
81PKN20.65677035
82CSNK1D0.65326438
83STK100.62989296
84PRKDC0.59182079
85EPHB20.56068822
86CSNK2A20.56058149
87PRKCI0.54856829
88CHUK0.51656543
89CSNK1E0.51519085
90RIPK10.50146227
91DYRK20.50022435
92RPS6KA50.49880370
93DYRK1A0.47703848
94FLT30.47463667
95MINK10.46411132
96* MAPK140.46325741
97STK240.46223035
98CDK180.45951462
99PRKCE0.45589276
100CSNK1A1L0.45415449
101STK390.44926671
102CSNK2A10.43139999
103AKT10.43017785
104LATS20.42625001
105AKT20.40267287
106CDK90.39414174
107EPHA30.38977330
108NEK60.38693580
109MARK30.38202353
110CSNK1G10.37224291
111GRK10.37183193
112* GSK3B0.36560408
113UHMK10.35070452
114PAK30.34741673
115CDK150.34512277
116FGFR10.34302759
117CCNB10.34004095
118PKN10.33336038
119CDK11A0.33031733
120SCYL20.32632201
121CDK140.32404818
122SGK20.32101202
123WNK30.31127880
124PRKCG0.30341351
125ERBB20.27853675
126KSR10.27140165
127* MAPK10.26788223
128FER0.26277224
129CDK80.25921310
130PRKACB0.25750294
131RPS6KB10.25585154
132TIE10.25150733
133BCR0.25041933
134CSNK1G30.24108641
135ERBB40.23787328
136CDK30.22779458
137MAPK100.22757570
138CLK10.21174461
139MAPK90.18771565

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.09751535
2DNA replication_Homo sapiens_hsa030304.06847749
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50139870
4RNA transport_Homo sapiens_hsa030133.06769216
5Spliceosome_Homo sapiens_hsa030403.05781148
6Homologous recombination_Homo sapiens_hsa034402.97732548
7Fanconi anemia pathway_Homo sapiens_hsa034602.94534988
8Cell cycle_Homo sapiens_hsa041102.93648571
9Non-homologous end-joining_Homo sapiens_hsa034502.65029558
10Nucleotide excision repair_Homo sapiens_hsa034202.64022252
11One carbon pool by folate_Homo sapiens_hsa006702.58189820
12Base excision repair_Homo sapiens_hsa034102.55835032
13RNA polymerase_Homo sapiens_hsa030202.40115703
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.34895375
15Systemic lupus erythematosus_Homo sapiens_hsa053222.34672729
16mRNA surveillance pathway_Homo sapiens_hsa030152.28196771
17Steroid biosynthesis_Homo sapiens_hsa001002.23119466
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14590013
19RNA degradation_Homo sapiens_hsa030182.05900217
20Protein export_Homo sapiens_hsa030601.98074958
21Basal transcription factors_Homo sapiens_hsa030221.87557384
22p53 signaling pathway_Homo sapiens_hsa041151.84692096
23Propanoate metabolism_Homo sapiens_hsa006401.81151296
24Pyrimidine metabolism_Homo sapiens_hsa002401.76922222
25Ribosome_Homo sapiens_hsa030101.69666347
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58927734
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49442629
28* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36849068
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.36423136
30MicroRNAs in cancer_Homo sapiens_hsa052061.35286059
31Viral carcinogenesis_Homo sapiens_hsa052031.30560606
32Basal cell carcinoma_Homo sapiens_hsa052171.27973669
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18575673
34Alcoholism_Homo sapiens_hsa050341.15887080
35Herpes simplex infection_Homo sapiens_hsa051681.10782876
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07607596
37Hippo signaling pathway_Homo sapiens_hsa043901.06193223
38Epstein-Barr virus infection_Homo sapiens_hsa051691.05668643
39Nicotine addiction_Homo sapiens_hsa050331.05571027
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03641960
41TGF-beta signaling pathway_Homo sapiens_hsa043501.02273828
42HTLV-I infection_Homo sapiens_hsa051660.99947680
43Oocyte meiosis_Homo sapiens_hsa041140.95692349
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95093125
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94938148
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93537166
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91540777
48Colorectal cancer_Homo sapiens_hsa052100.90720430
49Notch signaling pathway_Homo sapiens_hsa043300.90045428
50Small cell lung cancer_Homo sapiens_hsa052220.88764937
51Purine metabolism_Homo sapiens_hsa002300.88452990
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87898053
53Axon guidance_Homo sapiens_hsa043600.86553040
54Taste transduction_Homo sapiens_hsa047420.85600157
55Proteasome_Homo sapiens_hsa030500.85445504
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84719451
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81703458
58Lysine degradation_Homo sapiens_hsa003100.81536590
59Renin-angiotensin system_Homo sapiens_hsa046140.81384095
60Pyruvate metabolism_Homo sapiens_hsa006200.80691650
61Adherens junction_Homo sapiens_hsa045200.80604354
62Antigen processing and presentation_Homo sapiens_hsa046120.77251722
63Hedgehog signaling pathway_Homo sapiens_hsa043400.73633932
64Phototransduction_Homo sapiens_hsa047440.73015922
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71734979
66Butanoate metabolism_Homo sapiens_hsa006500.71156250
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.70539451
68Wnt signaling pathway_Homo sapiens_hsa043100.70128463
69Selenocompound metabolism_Homo sapiens_hsa004500.64864783
70Prostate cancer_Homo sapiens_hsa052150.63102622
71Pathways in cancer_Homo sapiens_hsa052000.61659928
72Thyroid cancer_Homo sapiens_hsa052160.60936890
73Chronic myeloid leukemia_Homo sapiens_hsa052200.60854173
74Biosynthesis of amino acids_Homo sapiens_hsa012300.57780196
75Fatty acid metabolism_Homo sapiens_hsa012120.57161949
76Circadian rhythm_Homo sapiens_hsa047100.55514067
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53737624
78FoxO signaling pathway_Homo sapiens_hsa040680.53692980
79Fatty acid elongation_Homo sapiens_hsa000620.53449138
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52714579
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52002632
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48960653
83Hepatitis B_Homo sapiens_hsa051610.48524619
84mTOR signaling pathway_Homo sapiens_hsa041500.48348540
85Apoptosis_Homo sapiens_hsa042100.47046974
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46642831
87Dopaminergic synapse_Homo sapiens_hsa047280.46456966
88Measles_Homo sapiens_hsa051620.45607199
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44571110
90Endometrial cancer_Homo sapiens_hsa052130.44323468
91Tight junction_Homo sapiens_hsa045300.41907540
92Long-term depression_Homo sapiens_hsa047300.40882692
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40569994
94Gap junction_Homo sapiens_hsa045400.39810418
95Carbon metabolism_Homo sapiens_hsa012000.39557746
96African trypanosomiasis_Homo sapiens_hsa051430.39268885
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39158382
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38940054
99Melanoma_Homo sapiens_hsa052180.37883520
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37647343
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36024918
102GABAergic synapse_Homo sapiens_hsa047270.35711474
103Melanogenesis_Homo sapiens_hsa049160.35123854
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34290627
105Olfactory transduction_Homo sapiens_hsa047400.33002131
106Legionellosis_Homo sapiens_hsa051340.32936510
107Viral myocarditis_Homo sapiens_hsa054160.32031478
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31867591
109Ether lipid metabolism_Homo sapiens_hsa005650.31570485
110Proteoglycans in cancer_Homo sapiens_hsa052050.31184609
111Hematopoietic cell lineage_Homo sapiens_hsa046400.30817633
112Primary immunodeficiency_Homo sapiens_hsa053400.30644940
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30416901
114Influenza A_Homo sapiens_hsa051640.29172156
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.29061781
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28838157
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28712822
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28530494
119Glutamatergic synapse_Homo sapiens_hsa047240.27873985
120Vitamin B6 metabolism_Homo sapiens_hsa007500.27160126
121Non-small cell lung cancer_Homo sapiens_hsa052230.25101450
122Pancreatic cancer_Homo sapiens_hsa052120.24939877
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24896767
124Graft-versus-host disease_Homo sapiens_hsa053320.24797727
125Bladder cancer_Homo sapiens_hsa052190.24770171
126Fatty acid biosynthesis_Homo sapiens_hsa000610.24405825
127Serotonergic synapse_Homo sapiens_hsa047260.21665988
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.21291432
129Acute myeloid leukemia_Homo sapiens_hsa052210.20910041
130Shigellosis_Homo sapiens_hsa051310.20591646
131Peroxisome_Homo sapiens_hsa041460.20124476
132Metabolic pathways_Homo sapiens_hsa011000.19592631
133ECM-receptor interaction_Homo sapiens_hsa045120.19188588
134TNF signaling pathway_Homo sapiens_hsa046680.18751021
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.18638337
136Focal adhesion_Homo sapiens_hsa045100.17901003
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17854469
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17465611
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.16310093
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.15700283
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15128225
142Vitamin digestion and absorption_Homo sapiens_hsa049770.15124361
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14785194
144T cell receptor signaling pathway_Homo sapiens_hsa046600.13923565
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.13848064

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