SLX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions as an assembly component of multiple structure-specific endonucleases. These endonuclease complexes are required for repair of specific types of DNA lesions and critical for cellular responses to replication fork failure. Mutations in this gene were found in patients with Fanconi anemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.15567967
2fusion of sperm to egg plasma membrane (GO:0007342)5.22713062
3nuclear pore complex assembly (GO:0051292)5.16847179
4piRNA metabolic process (GO:0034587)5.00031483
5sperm motility (GO:0030317)4.80564572
6sperm-egg recognition (GO:0035036)4.78541666
7behavioral response to nicotine (GO:0035095)4.74643197
8mitotic sister chromatid cohesion (GO:0007064)4.69506157
9meiotic chromosome segregation (GO:0045132)4.59904564
10nuclear pore organization (GO:0006999)4.51558475
11binding of sperm to zona pellucida (GO:0007339)4.50857817
12cell-cell recognition (GO:0009988)4.45288084
13acrosome assembly (GO:0001675)4.39889429
14synaptonemal complex assembly (GO:0007130)4.38989305
15synaptonemal complex organization (GO:0070193)4.26477458
16microtubule depolymerization (GO:0007019)4.19374703
17male meiosis (GO:0007140)4.18368491
18spermatid development (GO:0007286)4.03806198
19multicellular organism reproduction (GO:0032504)4.03281672
20pore complex assembly (GO:0046931)4.01051525
21histone H3-K36 demethylation (GO:0070544)4.00137486
22axonemal dynein complex assembly (GO:0070286)3.99677640
23motile cilium assembly (GO:0044458)3.99363177
24mannose metabolic process (GO:0006013)3.97415702
25monoubiquitinated protein deubiquitination (GO:0035520)3.96907419
26regulation of histone H3-K9 methylation (GO:0051570)3.96106800
27plasma membrane fusion (GO:0045026)3.88385825
28histone H3-K9 modification (GO:0061647)3.87110080
29gene silencing by RNA (GO:0031047)3.82240102
30positive regulation of CREB transcription factor activity (GO:0032793)3.80979067
31acrosome reaction (GO:0007340)3.77385059
32sister chromatid segregation (GO:0000819)3.76767365
33regulation of cilium movement (GO:0003352)3.67205929
34chromosome condensation (GO:0030261)3.66857054
35histone H3-K4 trimethylation (GO:0080182)3.63552215
36pre-miRNA processing (GO:0031054)3.61419321
37regulation of RNA export from nucleus (GO:0046831)3.60103408
38negative regulation of histone methylation (GO:0031061)3.59752573
39mitotic sister chromatid segregation (GO:0000070)3.58915203
40mitotic chromosome condensation (GO:0007076)3.55319377
41DNA packaging (GO:0006323)3.54135900
42protein localization to chromosome, centromeric region (GO:0071459)3.48566139
43cytoplasmic mRNA processing body assembly (GO:0033962)3.47928614
44translesion synthesis (GO:0019985)3.47066913
45heterochromatin organization (GO:0070828)3.46297524
46protein-DNA complex disassembly (GO:0032986)3.43326329
47nucleosome disassembly (GO:0006337)3.43326329
48gene silencing (GO:0016458)3.42310229
49epithelial cilium movement (GO:0003351)3.41842096
50dosage compensation (GO:0007549)3.38783233
51mitotic nuclear envelope disassembly (GO:0007077)3.37167529
52DNA replication-dependent nucleosome assembly (GO:0006335)3.36877714
53DNA replication-dependent nucleosome organization (GO:0034723)3.36877714
54positive regulation of gene expression, epigenetic (GO:0045815)3.36156911
55negative regulation of translation, ncRNA-mediated (GO:0040033)3.35473149
56regulation of translation, ncRNA-mediated (GO:0045974)3.35473149
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.35473149
58regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33582480
59reproduction (GO:0000003)3.33164983
60positive regulation by host of viral transcription (GO:0043923)3.33017283
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32051198
62regulation of histone H3-K4 methylation (GO:0051569)3.27276645
63regulation of centriole replication (GO:0046599)3.26337680
64chromosome organization involved in meiosis (GO:0070192)3.24806194
65meiotic nuclear division (GO:0007126)3.23387710
66membrane disassembly (GO:0030397)3.22666659
67nuclear envelope disassembly (GO:0051081)3.22666659
68male meiosis I (GO:0007141)3.21078200
69cell wall macromolecule catabolic process (GO:0016998)3.18994103
70cell wall macromolecule metabolic process (GO:0044036)3.18994103
71negative regulation of cell killing (GO:0031342)3.17380800
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.17380800
73histone lysine methylation (GO:0034968)3.15462204
74DNA methylation involved in gamete generation (GO:0043046)3.10852642
75positive regulation of mitotic sister chromatid separation (GO:1901970)3.09124711
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09124711
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09124711
78chromatin assembly (GO:0031497)3.05801814
79sister chromatid cohesion (GO:0007062)3.03228375
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02631351
81negative regulation of gene expression, epigenetic (GO:0045814)3.02436683
82L-fucose catabolic process (GO:0042355)3.00237756
83fucose catabolic process (GO:0019317)3.00237756
84L-fucose metabolic process (GO:0042354)3.00237756
85positive regulation of histone deacetylation (GO:0031065)2.97693285
86NLS-bearing protein import into nucleus (GO:0006607)2.95171141
87protein localization to kinetochore (GO:0034501)2.94292765
88peptidyl-lysine dimethylation (GO:0018027)2.92714214
89RNA stabilization (GO:0043489)2.92246325
90mRNA stabilization (GO:0048255)2.92246325
91regulation of chromatin binding (GO:0035561)2.91348260
92peptidyl-lysine trimethylation (GO:0018023)2.91081278
93peptidyl-lysine methylation (GO:0018022)2.89736322
94histone H3-K9 methylation (GO:0051567)2.89626231
95histone H3-K4 methylation (GO:0051568)2.88162348
96DNA conformation change (GO:0071103)2.87768661
97positive regulation of developmental pigmentation (GO:0048087)2.87502246
98DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.87284430
99cilium movement (GO:0003341)2.85665347
100DNA duplex unwinding (GO:0032508)2.85626789
101meiotic cell cycle (GO:0051321)2.85108064
102regulation of nucleobase-containing compound transport (GO:0032239)2.85033126
103DNA geometric change (GO:0032392)2.84785299
104meiosis I (GO:0007127)2.84678246
105histone methylation (GO:0016571)2.83758227
106chromatin silencing (GO:0006342)2.82217778
107spermatogenesis (GO:0007283)2.82130823
108glucocorticoid receptor signaling pathway (GO:0042921)2.82031672
109negative regulation of histone acetylation (GO:0035067)2.82014373
110male gamete generation (GO:0048232)2.81888306
111regulation of centrosome duplication (GO:0010824)2.81748434
112DNA unwinding involved in DNA replication (GO:0006268)2.81406578
113regulation of NFAT protein import into nucleus (GO:0051532)2.81027448
114positive regulation of chromosome segregation (GO:0051984)2.80083083
115microtubule nucleation (GO:0007020)2.79053257
116phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.78911905
117negative regulation of DNA repair (GO:0045738)2.78876676
118DNA methylation (GO:0006306)2.77636472
119DNA alkylation (GO:0006305)2.77636472
120meiotic cell cycle process (GO:1903046)2.77163829
121seminiferous tubule development (GO:0072520)2.76482886
122regulation of memory T cell differentiation (GO:0043380)2.75483742
123snRNA transcription (GO:0009301)2.73954070
124regulation of histone methylation (GO:0031060)2.72963608
125establishment of mitotic spindle localization (GO:0040001)2.72525955
126nucleus organization (GO:0006997)2.72236826
127embryonic hemopoiesis (GO:0035162)2.71357655
128regulation of centrosome cycle (GO:0046605)2.71315880
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.70661665
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70661665
131histone H2A acetylation (GO:0043968)2.70243382
132spindle assembly involved in mitosis (GO:0090307)2.68883982
133germ cell development (GO:0007281)2.68729014
134cellular process involved in reproduction in multicellular organism (GO:0022412)2.65721175
135negative regulation of organelle assembly (GO:1902116)2.63176051
136single fertilization (GO:0007338)2.62402435
137regulation of DNA endoreduplication (GO:0032875)2.61917408
138establishment of spindle localization (GO:0051293)2.61294447
139positive regulation of Rab GTPase activity (GO:0032851)2.60597937
140regulation of Rab GTPase activity (GO:0032313)2.60597937
141histone H4 deacetylation (GO:0070933)2.60372174
142replication fork processing (GO:0031297)2.59837208
143mRNA cleavage (GO:0006379)2.59079824
144regulation of hippo signaling (GO:0035330)2.57439227
145glycine transport (GO:0015816)2.57142446
146CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.56233662
147intracellular estrogen receptor signaling pathway (GO:0030520)2.55655937
148DNA damage response, signal transduction resulting in transcription (GO:0042772)2.54918341
149activated T cell proliferation (GO:0050798)2.52553854
150histone deubiquitination (GO:0016578)2.50403237
151TOR signaling (GO:0031929)2.49656149
152regulation of cilium assembly (GO:1902017)2.49428983
153positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.49190830
154spindle organization (GO:0007051)2.48884756
155negative regulation of histone modification (GO:0031057)2.46490828
156spindle assembly (GO:0051225)2.46040616
157purinergic nucleotide receptor signaling pathway (GO:0035590)2.43214179
158DNA strand renaturation (GO:0000733)2.42216818
159negative regulation of chromatin modification (GO:1903309)2.40223795
160DNA topological change (GO:0006265)2.40018822
161B cell receptor signaling pathway (GO:0050853)2.39386533
162snRNA metabolic process (GO:0016073)2.38223765
163positive regulation of defense response to virus by host (GO:0002230)2.36787981
164regulation of gene expression, epigenetic (GO:0040029)2.36012235
165opioid receptor signaling pathway (GO:0038003)2.35746705
166regulation of MHC class II biosynthetic process (GO:0045346)2.35724458
167positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.34217956
168establishment of spindle orientation (GO:0051294)2.33785062
169interkinetic nuclear migration (GO:0022027)2.33746340
170histone H3 deacetylation (GO:0070932)2.33373302
171establishment of mitotic spindle orientation (GO:0000132)2.32681595
172regulation of gene expression by genetic imprinting (GO:0006349)2.32508696
173N-terminal protein amino acid acetylation (GO:0006474)2.29067094
174histone acetylation (GO:0016573)2.28371266
175DNA methylation or demethylation (GO:0044728)2.28017684
176positive regulation of protein deacetylation (GO:0090312)2.26716546
177regulation of nuclear cell cycle DNA replication (GO:0033262)2.26360083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.38998623
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.48001427
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.99338308
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.39661029
5MYC_22102868_ChIP-Seq_BL_Human3.38161779
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.04739573
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.03497250
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99086946
9CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.72289925
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45602230
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.35658344
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30326267
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.24422312
14TCF7_22412390_ChIP-Seq_EML_Mouse2.21613692
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11510511
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.00419654
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98038953
18SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.97886271
19VDR_21846776_ChIP-Seq_THP-1_Human1.88824587
20CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.85812351
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85631303
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85023977
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.81697878
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81495480
25GATA1_19941827_ChIP-Seq_MEL_Mouse1.78185213
26CIITA_25753668_ChIP-Seq_RAJI_Human1.74760321
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74381345
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72089988
29GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70196702
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69931300
31DROSHA_22980978_ChIP-Seq_HELA_Human1.66167335
32KDM2B_26808549_Chip-Seq_DND41_Human1.65845214
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64273815
34UTX_26944678_Chip-Seq_JUKART_Human1.62158471
35ZNF274_21170338_ChIP-Seq_K562_Hela1.60610163
36MYB_26560356_Chip-Seq_TH1_Human1.50367721
37LXR_22292898_ChIP-Seq_THP-1_Human1.49862008
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48568418
39MAF_26560356_Chip-Seq_TH1_Human1.47339036
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.45957602
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45248170
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42917913
43OCT4_19829295_ChIP-Seq_ESCs_Human1.41519240
44IGF1R_20145208_ChIP-Seq_DFB_Human1.40267594
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.39902307
46E2F1_20622854_ChIP-Seq_HELA_Human1.39073945
47MYB_26560356_Chip-Seq_TH2_Human1.36324699
48BCOR_27268052_Chip-Seq_Bcells_Human1.36141741
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36061431
50KDM2B_26808549_Chip-Seq_K562_Human1.35902240
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34759288
52SMC4_20622854_ChIP-Seq_HELA_Human1.32195021
53GATA1_19941826_ChIP-Seq_K562_Human1.31469049
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31346291
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31195517
56BCL6_27268052_Chip-Seq_Bcells_Human1.31136373
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30514043
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30392156
59AR_21909140_ChIP-Seq_LNCAP_Human1.30219726
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30045646
61SCL_19346495_ChIP-Seq_HPC-7_Human1.29679654
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27804877
63MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.26303893
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25513288
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23882533
66RARA_24833708_ChIP-Seq_LIVER_Mouse1.23578114
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.21689603
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20675233
69KDM5A_27292631_Chip-Seq_BREAST_Human1.18864871
70BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.18673851
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17028060
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16402829
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16391015
74ERA_21632823_ChIP-Seq_H3396_Human1.15511579
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14588787
76REST_21632747_ChIP-Seq_MESCs_Mouse1.14042247
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13960984
78CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13235621
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13212577
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12814741
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12530614
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11487754
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11412839
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11178125
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10490441
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10276842
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10236457
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07650595
89FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06469000
90EZH2_22144423_ChIP-Seq_EOC_Human1.06248350
91WDR5_24793694_ChIP-Seq_LNCAP_Human1.06060353
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05274843
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04154891
94E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03915812
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.02199628
96BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02168901
97VDR_24763502_ChIP-Seq_THP-1_Human1.01793561
98NCOR1_26117541_ChIP-Seq_K562_Human0.99985887
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97986570
100CTCF_20526341_ChIP-Seq_ESCs_Human0.97561535
101KDM2B_26808549_Chip-Seq_JURKAT_Human0.97098925
102GATA2_19941826_ChIP-Seq_K562_Human0.96614279
103MAF_26560356_Chip-Seq_TH2_Human0.96573103
104RAC3_21632823_ChIP-Seq_H3396_Human0.95630563
105OCT4_20526341_ChIP-Seq_ESCs_Human0.95605125
106ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94579028
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.94087617
108RARB_27405468_Chip-Seq_BRAIN_Mouse0.93838276
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93605696
110TP53_23651856_ChIP-Seq_MEFs_Mouse0.93386801
111KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92803707
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92687823
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92089042
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91833213
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91366395
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91307246
117RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91077838
118SPI1_23127762_ChIP-Seq_K562_Human0.89375257
119TP53_22127205_ChIP-Seq_IMR90_Human0.89014696
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88714496
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88613738
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88421505
123P300_27268052_Chip-Seq_Bcells_Human0.88177517
124FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88155598
125REST_18959480_ChIP-ChIP_MESCs_Mouse0.87188155
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86553404
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85564663
128TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83768693
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81074351
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80282952
131ELK3_25401928_ChIP-Seq_HUVEC_Human0.79664472
132GATA3_27048872_Chip-Seq_THYMUS_Human0.79426613
133RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78820868
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77778331
135PHF8_20622854_ChIP-Seq_HELA_Human0.77112177
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76611426
137P68_20966046_ChIP-Seq_HELA_Human0.76586087
138FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74451404
139XRN2_22483619_ChIP-Seq_HELA_Human0.74300200
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74238654
141MYC_19030024_ChIP-ChIP_MESCs_Mouse0.73940015
142MYC_18555785_ChIP-Seq_MESCs_Mouse0.73894379
143EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.73238848
144POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.72373893
145ZFP281_18757296_ChIP-ChIP_E14_Mouse0.70270330
146GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70219376
147SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.70005367
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.69354976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.40049342
2MP0008877_abnormal_DNA_methylation3.78335259
3MP0010094_abnormal_chromosome_stability3.44633467
4MP0003111_abnormal_nucleus_morphology3.31804761
5MP0000569_abnormal_digit_pigmentation3.28514314
6MP0000015_abnormal_ear_pigmentation3.06976453
7MP0003136_yellow_coat_color2.90340454
8MP0005083_abnormal_biliary_tract2.86271870
9MP0008057_abnormal_DNA_replication2.73970453
10MP0001968_abnormal_touch/_nociception2.68489893
11MP0001929_abnormal_gametogenesis2.65843495
12MP0003698_abnormal_male_reproductive2.63527377
13MP0003077_abnormal_cell_cycle2.62228319
14MP0004381_abnormal_hair_follicle2.60728048
15MP0005076_abnormal_cell_differentiation2.50025444
16MP0004808_abnormal_hematopoietic_stem2.35558172
17MP0003693_abnormal_embryo_hatching2.34448970
18MP0002653_abnormal_ependyma_morphology2.34012789
19MP0003172_abnormal_lysosome_physiology2.33400512
20MP0010352_gastrointestinal_tract_polyps2.25891536
21MP0010307_abnormal_tumor_latency2.21912743
22MP0008058_abnormal_DNA_repair2.21748867
23MP0002396_abnormal_hematopoietic_system2.19137030
24MP0009278_abnormal_bone_marrow2.04090049
25MP0002210_abnormal_sex_determination2.03131074
26MP0008007_abnormal_cellular_replicative1.97619976
27MP0005499_abnormal_olfactory_system1.80097002
28MP0005394_taste/olfaction_phenotype1.80097002
29MP0001145_abnormal_male_reproductive1.78256529
30MP0002736_abnormal_nociception_after1.75938788
31MP0001730_embryonic_growth_arrest1.74616913
32MP0002735_abnormal_chemical_nociception1.74472307
33MP0004957_abnormal_blastocyst_morpholog1.71403447
34MP0003787_abnormal_imprinting1.69885948
35MP0008961_abnormal_basal_metabolism1.69218800
36MP0005310_abnormal_salivary_gland1.67659669
37MP0000350_abnormal_cell_proliferation1.67658051
38MP0005397_hematopoietic_system_phenotyp1.59343701
39MP0001545_abnormal_hematopoietic_system1.59343701
40MP0002161_abnormal_fertility/fecundity1.56184477
41MP0000703_abnormal_thymus_morphology1.53676240
42MP0003121_genomic_imprinting1.51254176
43MP0006292_abnormal_olfactory_placode1.49768676
44MP0000653_abnormal_sex_gland1.47757844
45MP0003763_abnormal_thymus_physiology1.46602120
46MP0001672_abnormal_embryogenesis/_devel1.46281780
47MP0005380_embryogenesis_phenotype1.46281780
48MP0002084_abnormal_developmental_patter1.46102767
49MP0004859_abnormal_synaptic_plasticity1.44890036
50MP0004233_abnormal_muscle_weight1.42743589
51MP0004197_abnormal_fetal_growth/weight/1.42314506
52MP0001919_abnormal_reproductive_system1.41704367
53MP0008872_abnormal_physiological_respon1.41565679
54MP0002398_abnormal_bone_marrow1.41375361
55MP0003984_embryonic_growth_retardation1.39908435
56MP0001873_stomach_inflammation1.38260566
57MP0003705_abnormal_hypodermis_morpholog1.37936676
58MP0002088_abnormal_embryonic_growth/wei1.36749766
59MP0001697_abnormal_embryo_size1.36483986
60MP0001835_abnormal_antigen_presentation1.35422994
61MP0009046_muscle_twitch1.31786866
62MP0002085_abnormal_embryonic_tissue1.26510682
63MP0002086_abnormal_extraembryonic_tissu1.25547994
64MP0001986_abnormal_taste_sensitivity1.25100675
65MP0003646_muscle_fatigue1.24447349
66MP0005464_abnormal_platelet_physiology1.23546567
67MP0003890_abnormal_embryonic-extraembry1.23467046
68MP0003300_gastrointestinal_ulcer1.22261993
69MP0000313_abnormal_cell_death1.21740182
70MP0005387_immune_system_phenotype1.21143662
71MP0001790_abnormal_immune_system1.21143662
72MP0005645_abnormal_hypothalamus_physiol1.21129271
73MP0002080_prenatal_lethality1.19481062
74MP0003635_abnormal_synaptic_transmissio1.18948588
75MP0003303_peritoneal_inflammation1.18218740
76MP0005623_abnormal_meninges_morphology1.16406260
77MP0000427_abnormal_hair_cycle1.15812273
78MP0002722_abnormal_immune_system1.12077521
79MP0002063_abnormal_learning/memory/cond1.10869137
80MP0003786_premature_aging1.07305803
81MP0000689_abnormal_spleen_morphology1.03004927
82MP0002019_abnormal_tumor_incidence1.02659040
83MP0000490_abnormal_crypts_of1.02572343
84MP0009703_decreased_birth_body1.02286480
85MP0000371_diluted_coat_color1.02268809
86MP0005423_abnormal_somatic_nervous1.01837532
87MP0003123_paternal_imprinting1.01731490
88MP0001293_anophthalmia0.99613817
89MP0005075_abnormal_melanosome_morpholog0.99015250
90MP0002067_abnormal_sensory_capabilities0.99004322
91MP0001970_abnormal_pain_threshold0.98746659
92MP0000778_abnormal_nervous_system0.98109713
93MP0001800_abnormal_humoral_immune0.97388855
94MP0003115_abnormal_respiratory_system0.96591857
95MP0002160_abnormal_reproductive_system0.95526553
96MP0000733_abnormal_muscle_development0.94553766
97MP0004264_abnormal_extraembryonic_tissu0.92871526
98MP0001849_ear_inflammation0.91103954
99MP0002572_abnormal_emotion/affect_behav0.90621894
100MP0008789_abnormal_olfactory_epithelium0.90585386
101MP0002166_altered_tumor_susceptibility0.89520510
102MP0001915_intracranial_hemorrhage0.89440117
103MP0005621_abnormal_cell_physiology0.89395426
104MP0002095_abnormal_skin_pigmentation0.87883153
105MP0002733_abnormal_thermal_nociception0.87842544
106MP0009745_abnormal_behavioral_response0.87364291
107MP0000716_abnormal_immune_system0.87203494
108MP0001661_extended_life_span0.86145231
109MP0001348_abnormal_lacrimal_gland0.85876599
110MP0002064_seizures0.85531828
111MP0008932_abnormal_embryonic_tissue0.85521220
112MP0002152_abnormal_brain_morphology0.84109192
113MP0004130_abnormal_muscle_cell0.83815147
114MP0002429_abnormal_blood_cell0.83641652
115MP0003861_abnormal_nervous_system0.83502657
116MP0005171_absent_coat_pigmentation0.83192939
117MP0000428_abnormal_craniofacial_morphol0.82976972
118MP0002272_abnormal_nervous_system0.82582283
119MP0003119_abnormal_digestive_system0.81864918
120MP0002928_abnormal_bile_duct0.81819713
121MP0005000_abnormal_immune_tolerance0.81618845
122MP0005384_cellular_phenotype0.81359033
123MP0004811_abnormal_neuron_physiology0.81242597
124MP0001663_abnormal_digestive_system0.80936432
125MP0009672_abnormal_birth_weight0.79212873
126MP0005671_abnormal_response_to0.79010141
127MP0008770_decreased_survivor_rate0.78598940
128MP0003566_abnormal_cell_adhesion0.78478022
129MP0002075_abnormal_coat/hair_pigmentati0.78452427
130MP0005389_reproductive_system_phenotype0.77347133
131MP0000631_abnormal_neuroendocrine_gland0.76670653
132MP0002092_abnormal_eye_morphology0.75973866
133MP0002925_abnormal_cardiovascular_devel0.74696588
134MP0002234_abnormal_pharynx_morphology0.74669763
135MP0003656_abnormal_erythrocyte_physiolo0.74326187
136MP0004133_heterotaxia0.74163190
137MP0005386_behavior/neurological_phenoty0.74147283
138MP0004924_abnormal_behavior0.74147283
139MP0005174_abnormal_tail_pigmentation0.72228032
140MP0000537_abnormal_urethra_morphology0.70745628
141MP0002420_abnormal_adaptive_immunity0.70397910
142MP0000685_abnormal_immune_system0.70011941
143MP0003935_abnormal_craniofacial_develop0.69204933
144MP0003091_abnormal_cell_migration0.69196594
145MP0001819_abnormal_immune_cell0.68117931
146MP0002405_respiratory_system_inflammati0.68025498
147MP0009333_abnormal_splenocyte_physiolog0.67278454
148MP0008995_early_reproductive_senescence0.66468280
149MP0002452_abnormal_antigen_presenting0.66165357
150MP0003045_fibrosis0.61258250
151MP0000432_abnormal_head_morphology0.60680359
152MP0001784_abnormal_fluid_regulation0.60543113
153MP0002723_abnormal_immune_serum0.59690347
154MP0002006_tumorigenesis0.59479072
155MP0003866_abnormal_defecation0.58736830

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.21618521
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.72689513
3Absent/shortened dynein arms (HP:0200106)4.72689513
4Type II lissencephaly (HP:0007260)4.21024794
5Nasal polyposis (HP:0100582)3.86413381
6Cerebellar dysplasia (HP:0007033)3.79036350
7Abnormality of the fingertips (HP:0001211)3.43290413
8Heterotopia (HP:0002282)3.35995522
9Lissencephaly (HP:0001339)3.27546370
10Rhinitis (HP:0012384)3.16183417
11Abnormal respiratory motile cilium physiology (HP:0012261)3.12456634
12Protruding tongue (HP:0010808)3.07195595
13Abnormality of the lower motor neuron (HP:0002366)3.06252008
14Abnormal respiratory epithelium morphology (HP:0012253)2.99289295
15Abnormal respiratory motile cilium morphology (HP:0005938)2.99289295
16Abnormality of the nasal mucosa (HP:0000433)2.96329631
17Chronic mucocutaneous candidiasis (HP:0002728)2.85859158
18Recurrent cutaneous fungal infections (HP:0011370)2.85859158
19Deep palmar crease (HP:0006191)2.84281269
20Recurrent bronchitis (HP:0002837)2.80990395
21Bronchitis (HP:0012387)2.79364689
22Chronic bronchitis (HP:0004469)2.76926130
23Ependymoma (HP:0002888)2.76245012
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.74865321
25Short 4th metacarpal (HP:0010044)2.74865321
26Clumsiness (HP:0002312)2.74730511
27Infertility (HP:0000789)2.70503999
28Pachygyria (HP:0001302)2.67999676
29Patellar aplasia (HP:0006443)2.64802540
30Medulloblastoma (HP:0002885)2.62490644
31Amyotrophic lateral sclerosis (HP:0007354)2.62334672
32Volvulus (HP:0002580)2.60199693
33Hyperacusis (HP:0010780)2.59494404
34Astrocytoma (HP:0009592)2.56821726
35Abnormality of the astrocytes (HP:0100707)2.56821726
36Impulsivity (HP:0100710)2.56548868
37Genetic anticipation (HP:0003743)2.50944128
38Nephronophthisis (HP:0000090)2.50548629
39High anterior hairline (HP:0009890)2.50039182
40Aplasia/Hypoplasia of the patella (HP:0006498)2.48868991
41Recurrent otitis media (HP:0000403)2.46228112
42Intellectual disability, severe (HP:0010864)2.42096279
43Increased nuchal translucency (HP:0010880)2.36565919
44Bronchiectasis (HP:0002110)2.36501678
45Tented upper lip vermilion (HP:0010804)2.31037957
46Partial agenesis of the corpus callosum (HP:0001338)2.30920499
47Chromsome breakage (HP:0040012)2.28787212
48High pitched voice (HP:0001620)2.27479244
49Prominent nose (HP:0000448)2.23191270
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20458907
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18549719
52Absent frontal sinuses (HP:0002688)2.17457976
53Long eyelashes (HP:0000527)2.15704118
54Glioma (HP:0009733)2.15607011
55Neoplasm of the adrenal cortex (HP:0100641)2.12550384
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11842370
57Prolonged bleeding time (HP:0003010)2.11839369
58Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09930648
59Progressive cerebellar ataxia (HP:0002073)2.08812896
60Truncal obesity (HP:0001956)2.08777622
61Polymicrogyria (HP:0002126)2.08117945
62Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06160020
63Hypoplasia of the brainstem (HP:0002365)2.06160020
64Abnormality of midbrain morphology (HP:0002418)2.05131624
65Molar tooth sign on MRI (HP:0002419)2.05131624
66Abnormality of the anterior horn cell (HP:0006802)2.04530526
67Degeneration of anterior horn cells (HP:0002398)2.04530526
68Urinary bladder sphincter dysfunction (HP:0002839)2.04375718
69* Abnormality of chromosome stability (HP:0003220)2.04202354
70IgA deficiency (HP:0002720)2.01892735
71Abnormal ciliary motility (HP:0012262)2.01514622
72Poikiloderma (HP:0001029)2.01225564
73Hypoplasia of the pons (HP:0012110)2.01061155
74Renal duplication (HP:0000075)2.00975093
75Hyperventilation (HP:0002883)1.99618851
76Abnormality of the columella (HP:0009929)1.98762864
77Renovascular hypertension (HP:0100817)1.96982373
78Cerebral aneurysm (HP:0004944)1.95787214
79Macroorchidism (HP:0000053)1.93246932
80Recurrent sinusitis (HP:0011108)1.92621769
81Abnormality of the renal medulla (HP:0100957)1.91978526
82Panhypogammaglobulinemia (HP:0003139)1.90940822
83Abnormal delayed hypersensitivity skin test (HP:0002963)1.90845644
84Urethral obstruction (HP:0000796)1.90630729
85Retinal dysplasia (HP:0007973)1.89618515
86Abnormality of DNA repair (HP:0003254)1.89593426
87* Squamous cell carcinoma (HP:0002860)1.86391283
88Elfin facies (HP:0004428)1.85771823
89Abnormality of ocular smooth pursuit (HP:0000617)1.85639928
90Broad distal phalanx of finger (HP:0009836)1.85113323
91Neoplasm of the oral cavity (HP:0100649)1.84529288
92Abnormality of incisor morphology (HP:0011063)1.84129014
93Thoracic kyphosis (HP:0002942)1.83952313
94Chronic hepatic failure (HP:0100626)1.83647169
95Rib fusion (HP:0000902)1.83342600
96Basal cell carcinoma (HP:0002671)1.80702485
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80166135
98Intestinal fistula (HP:0100819)1.79386799
99Bowel diverticulosis (HP:0005222)1.78192259
100Macroglossia (HP:0000158)1.78120051
101* Ectopic kidney (HP:0000086)1.77934446
102Tubular atrophy (HP:0000092)1.77907293
103* Abnormality of the carotid arteries (HP:0005344)1.76966070
104Male infertility (HP:0003251)1.76027752
105Gaze-evoked nystagmus (HP:0000640)1.75941036
106Dandy-Walker malformation (HP:0001305)1.73533860
107Skull defect (HP:0001362)1.73468993
108Aqueductal stenosis (HP:0002410)1.73406567
109Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73172283
110* Cafe-au-lait spot (HP:0000957)1.72876165
111Abnormality of the pons (HP:0007361)1.72758879
112Broad palm (HP:0001169)1.72640675
113* Aplasia/Hypoplasia of the uvula (HP:0010293)1.71040467
114Abnormality of the thoracic spine (HP:0100711)1.70812744
115Acute lymphatic leukemia (HP:0006721)1.70750277
116Selective tooth agenesis (HP:0001592)1.69605695
117Dislocated radial head (HP:0003083)1.68841444
118Abnormality of the 4th metacarpal (HP:0010012)1.68415699
119* Myelodysplasia (HP:0002863)1.68278760
120Thyroiditis (HP:0100646)1.67134885
121Insomnia (HP:0100785)1.66947047
122Hypoplastic labia majora (HP:0000059)1.66530413
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.65844382
124Recurrent fungal infections (HP:0002841)1.65063992
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.65034640
126Abnormality of the incisor (HP:0000676)1.64554726
127Tapered finger (HP:0001182)1.64411048
128Cheilitis (HP:0100825)1.64178385
129Short ribs (HP:0000773)1.63684647
130Annular pancreas (HP:0001734)1.62393416
131Severe muscular hypotonia (HP:0006829)1.61520252
132Neoplasm of striated muscle (HP:0009728)1.61398426
133Ocular albinism (HP:0001107)1.61024104
134Obsessive-compulsive behavior (HP:0000722)1.59785957
135Optic nerve coloboma (HP:0000588)1.59467695
136Pointed chin (HP:0000307)1.59399607
137Anterior segment dysgenesis (HP:0007700)1.59260291
138Smooth philtrum (HP:0000319)1.58826298
139Abnormality of the radial head (HP:0003995)1.58568018
140Highly arched eyebrow (HP:0002553)1.58402259
141Hypoplastic iliac wings (HP:0002866)1.58237378
142* Sloping forehead (HP:0000340)1.58100041
143Anal stenosis (HP:0002025)1.57881793
144Acute myeloid leukemia (HP:0004808)1.56972036
145Sacral dimple (HP:0000960)1.56856292
146Sandal gap (HP:0001852)1.56555450
147Dysmetric saccades (HP:0000641)1.56224004
148Hand muscle atrophy (HP:0009130)1.55761341
149* Abnormality of the ileum (HP:0001549)1.55731921
150Trigonocephaly (HP:0000243)1.54509558
151Amaurosis fugax (HP:0100576)1.54456997
152Cerebellar hypoplasia (HP:0001321)1.54107282
153Short chin (HP:0000331)1.54060537
154Increased density of long bones (HP:0006392)1.53754545
155Colitis (HP:0002583)1.53720606
156* Meckel diverticulum (HP:0002245)1.53580173
157Hypoplastic nipples (HP:0002557)1.53510707
158Spina bifida occulta (HP:0003298)1.52969218
159Deviation of the thumb (HP:0009603)1.51802281
160Facial hemangioma (HP:0000329)1.51553948
161T lymphocytopenia (HP:0005403)1.51328761
162Bicuspid aortic valve (HP:0001647)1.51205887
163Non-midline cleft lip (HP:0100335)1.51105204
164Supernumerary nipples (HP:0002558)1.50952258
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.50761402
166Absent epiphyses (HP:0010577)1.50761402
167Narrow palate (HP:0000189)1.50617556
168Broad phalanges of the hand (HP:0009768)1.50168751
169IgG deficiency (HP:0004315)1.50155248
170Abnormality of chromosome segregation (HP:0002916)1.50024219
171Papillary thyroid carcinoma (HP:0002895)1.49007621
17211 pairs of ribs (HP:0000878)1.48898577
173Megalocornea (HP:0000485)1.48707515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.20989522
2NEK23.71573305
3PDK43.47772697
4PDK33.47772697
5MAP3K103.44817767
6ICK3.14510040
7CDC72.95730008
8PRKD32.86433934
9EEF2K2.83709853
10TESK12.50440314
11FRK2.21998919
12TRIB32.18830190
13MAP4K12.03157682
14SIK21.81021617
15BRD41.78898440
16ATR1.60755365
17PKN21.58817323
18TTK1.58481188
19CAMK1G1.55728970
20SCYL21.51717698
21CHEK21.47000151
22STK381.43958401
23PNCK1.43941003
24STK101.42027094
25PDK21.39216887
26SMG11.38551820
27CHEK11.36449724
28MTOR1.34656038
29LATS11.33714729
30TLK11.32384938
31MAP3K91.25928658
32SIK31.24233607
33MAPK131.23205196
34CAMKK21.21700247
35PINK11.17858806
36BMPR1B1.13773240
37SIK11.13766405
38RIPK41.13621570
39WNK41.12620030
40PASK1.12034743
41CAMK1D1.11963753
42CDK41.10896859
43CAMK41.07934383
44STK31.07514040
45MUSK1.07472231
46TNIK1.06242007
47ALK1.06188809
48RPS6KA61.05807870
49RPS6KA21.04207307
50PTK61.02950555
51MAPK111.01534148
52CCNB11.01361987
53PLK11.00066075
54MAP3K130.99407287
55SGK20.98003613
56* ATM0.97101302
57CDK60.95100244
58PTK2B0.90469089
59TAOK10.89245012
60RPS6KC10.89181438
61RPS6KL10.89181438
62TYRO30.88025470
63CDK20.86619176
64RIPK10.85190697
65GRK60.84411893
66ERN10.82438885
67PAK60.80332341
68MAP2K70.78344231
69MARK20.78183062
70ZAK0.77501145
71TNK20.77285846
72FGFR20.76583998
73PAK20.74147907
74DYRK1B0.73234648
75ADRBK20.73213417
76AURKB0.72759869
77BRSK10.71687417
78STK40.71169313
79TAOK30.70987201
80NEK10.70910001
81CSF1R0.70867306
82SGK2230.70649964
83SGK4940.70649964
84CAMK10.70235897
85PRKCQ0.69585229
86TEC0.69301113
87CDK30.68460031
88PIM10.68347421
89BLK0.68148931
90DYRK30.66904737
91STK110.66750120
92LATS20.66188229
93CDK70.66062395
94WEE10.64775244
95PRKD20.64676771
96CDK10.63959303
97RPS6KB20.62385113
98PRPF4B0.59742393
99PRKCI0.58574187
100ZAP700.58004580
101PRKCZ0.57780025
102IRAK40.56854739
103PRKDC0.56707586
104MAP3K80.56455838
105PLK30.56097780
106CDK90.55593482
107WNK10.55519346
108BMX0.55442650
109RPS6KB10.54633513
110CAMKK10.54262034
111IRAK30.53760425
112CHUK0.51455016
113RPS6KA40.51085986
114JAK10.51072613
115IKBKB0.50938256
116AURKA0.50221359
117MARK30.50214784
118BTK0.49607347
119SGK30.49207960
120TTN0.49031565
121MAPK140.47124907
122HCK0.46818670
123CDC42BPA0.46814057
124PRKAA10.46084556
125MARK10.46077569
126WNK30.45408173
127CSNK1D0.45372499
128HIPK20.44762555
129GSK3B0.44680911
130PDGFRB0.44400823
131ITK0.44014596
132PAK40.42983782
133PDK10.42412844
134NTRK20.41946394
135BUB10.41908078
136SYK0.41556082
137PLK40.41224169
138PKN10.39152147
139TSSK60.38774991
140MAPKAPK30.38158030
141PDGFRA0.37002938
142TXK0.35052611
143AKT10.34507693
144MAPK80.34030080
145JAK30.32913071
146PRKCH0.31762940
147FGFR10.31226392

Predicted pathways (KEGG)

RankGene SetZ-score
1mRNA surveillance pathway_Homo sapiens_hsa030152.03295247
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.00708069
3DNA replication_Homo sapiens_hsa030301.99784351
4RNA transport_Homo sapiens_hsa030131.96132606
5* Fanconi anemia pathway_Homo sapiens_hsa034601.95982113
6Cell cycle_Homo sapiens_hsa041101.94400362
7Mismatch repair_Homo sapiens_hsa034301.71320646
8Base excision repair_Homo sapiens_hsa034101.65118815
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64326485
10Primary immunodeficiency_Homo sapiens_hsa053401.63353936
11Non-homologous end-joining_Homo sapiens_hsa034501.59892492
12B cell receptor signaling pathway_Homo sapiens_hsa046621.54634864
13Spliceosome_Homo sapiens_hsa030401.44272719
14mTOR signaling pathway_Homo sapiens_hsa041501.43829363
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41223636
16Oocyte meiosis_Homo sapiens_hsa041141.40498631
17Chronic myeloid leukemia_Homo sapiens_hsa052201.33092109
18p53 signaling pathway_Homo sapiens_hsa041151.28171286
19Viral carcinogenesis_Homo sapiens_hsa052031.27821448
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27149863
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25041996
22Antigen processing and presentation_Homo sapiens_hsa046121.25002630
23Homologous recombination_Homo sapiens_hsa034401.23173377
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.22141584
25Nicotine addiction_Homo sapiens_hsa050331.21679299
26HTLV-I infection_Homo sapiens_hsa051661.21655579
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20673036
28Lysine degradation_Homo sapiens_hsa003101.19775536
29T cell receptor signaling pathway_Homo sapiens_hsa046601.16742803
30Platelet activation_Homo sapiens_hsa046111.16092292
31Colorectal cancer_Homo sapiens_hsa052101.12661122
32MicroRNAs in cancer_Homo sapiens_hsa052061.12189972
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12117291
34Choline metabolism in cancer_Homo sapiens_hsa052311.09877718
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09686499
36Glucagon signaling pathway_Homo sapiens_hsa049221.08020172
37Dorso-ventral axis formation_Homo sapiens_hsa043201.04994297
38Non-small cell lung cancer_Homo sapiens_hsa052231.03074304
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02777409
40Basal transcription factors_Homo sapiens_hsa030221.01696937
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00358478
42Small cell lung cancer_Homo sapiens_hsa052221.00087628
43Nucleotide excision repair_Homo sapiens_hsa034200.98371514
44Olfactory transduction_Homo sapiens_hsa047400.98186903
45RNA degradation_Homo sapiens_hsa030180.97802715
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97336973
47Herpes simplex infection_Homo sapiens_hsa051680.97072915
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96426680
49Systemic lupus erythematosus_Homo sapiens_hsa053220.96063816
50Acute myeloid leukemia_Homo sapiens_hsa052210.94633749
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94452862
52Pancreatic cancer_Homo sapiens_hsa052120.94276313
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.92231945
54Endometrial cancer_Homo sapiens_hsa052130.91803991
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.91669286
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89897428
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89523114
58Measles_Homo sapiens_hsa051620.88406722
59Cholinergic synapse_Homo sapiens_hsa047250.88185106
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87954796
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.87736452
62Epstein-Barr virus infection_Homo sapiens_hsa051690.87540538
63Melanoma_Homo sapiens_hsa052180.87481101
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87408572
65VEGF signaling pathway_Homo sapiens_hsa043700.86489624
66Morphine addiction_Homo sapiens_hsa050320.86042329
67Type II diabetes mellitus_Homo sapiens_hsa049300.85801316
68Notch signaling pathway_Homo sapiens_hsa043300.85378633
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85276890
70Oxytocin signaling pathway_Homo sapiens_hsa049210.84075844
71Phototransduction_Homo sapiens_hsa047440.82179944
72Glioma_Homo sapiens_hsa052140.82050378
73Hepatitis B_Homo sapiens_hsa051610.81572287
74Inositol phosphate metabolism_Homo sapiens_hsa005620.81375593
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80066456
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79660745
77Long-term potentiation_Homo sapiens_hsa047200.79404358
78Estrogen signaling pathway_Homo sapiens_hsa049150.79353587
79Basal cell carcinoma_Homo sapiens_hsa052170.78792841
80Alcoholism_Homo sapiens_hsa050340.77607393
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.75950055
82Chemokine signaling pathway_Homo sapiens_hsa040620.75729210
83Viral myocarditis_Homo sapiens_hsa054160.75520921
84Osteoclast differentiation_Homo sapiens_hsa043800.75364932
85Gap junction_Homo sapiens_hsa045400.74847822
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74588180
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71978423
88FoxO signaling pathway_Homo sapiens_hsa040680.71003597
89Toxoplasmosis_Homo sapiens_hsa051450.70038811
90Taste transduction_Homo sapiens_hsa047420.69434446
91Influenza A_Homo sapiens_hsa051640.69216393
92Selenocompound metabolism_Homo sapiens_hsa004500.69151158
93Prostate cancer_Homo sapiens_hsa052150.68759274
94Long-term depression_Homo sapiens_hsa047300.68639059
95Proteoglycans in cancer_Homo sapiens_hsa052050.67579025
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66967927
97Prolactin signaling pathway_Homo sapiens_hsa049170.66730944
98Glutamatergic synapse_Homo sapiens_hsa047240.66609517
99Hedgehog signaling pathway_Homo sapiens_hsa043400.65697275
100Apoptosis_Homo sapiens_hsa042100.65470106
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65271012
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64906917
103Circadian entrainment_Homo sapiens_hsa047130.64802325
104ABC transporters_Homo sapiens_hsa020100.64318806
105MAPK signaling pathway_Homo sapiens_hsa040100.62932688
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.62598120
107Wnt signaling pathway_Homo sapiens_hsa043100.62215947
108Adherens junction_Homo sapiens_hsa045200.60844104
109Hippo signaling pathway_Homo sapiens_hsa043900.60491883
110One carbon pool by folate_Homo sapiens_hsa006700.59521395
111Hematopoietic cell lineage_Homo sapiens_hsa046400.59516253
112Endocytosis_Homo sapiens_hsa041440.58962426
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58956870
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58240406
115AMPK signaling pathway_Homo sapiens_hsa041520.57917466
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57686972
117Amphetamine addiction_Homo sapiens_hsa050310.57568218
118Calcium signaling pathway_Homo sapiens_hsa040200.57391554
119Shigellosis_Homo sapiens_hsa051310.57082716
120Bladder cancer_Homo sapiens_hsa052190.56677680
121Vitamin B6 metabolism_Homo sapiens_hsa007500.56143079
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55592071
123Axon guidance_Homo sapiens_hsa043600.55115439
124ErbB signaling pathway_Homo sapiens_hsa040120.54648413
125TNF signaling pathway_Homo sapiens_hsa046680.54434982
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54365291
127HIF-1 signaling pathway_Homo sapiens_hsa040660.53973212
128Renal cell carcinoma_Homo sapiens_hsa052110.53942042
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53429629
130Tuberculosis_Homo sapiens_hsa051520.52342420
131Insulin signaling pathway_Homo sapiens_hsa049100.52297081
132Insulin resistance_Homo sapiens_hsa049310.52145731
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.51737866
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51527891
135Pathways in cancer_Homo sapiens_hsa052000.51265419
136cAMP signaling pathway_Homo sapiens_hsa040240.51066728
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51058494
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50610113

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