SLX1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)7.14018676
2negative regulation of execution phase of apoptosis (GO:1900118)6.93379885
3positive regulation of protein kinase C signaling (GO:0090037)6.70021478
4axon ensheathment in central nervous system (GO:0032291)6.56735617
5central nervous system myelination (GO:0022010)6.56735617
6presynaptic membrane assembly (GO:0097105)5.96681364
7presynaptic membrane organization (GO:0097090)5.27014399
8postsynaptic membrane organization (GO:0001941)5.20262855
9melanin metabolic process (GO:0006582)4.68677385
10melanin biosynthetic process (GO:0042438)4.61816865
11negative regulation of keratinocyte proliferation (GO:0010839)4.44792431
12eyelid development in camera-type eye (GO:0061029)4.40091761
13GMP metabolic process (GO:0046037)4.27791866
14metanephric nephron tubule development (GO:0072234)4.25911956
15metanephric tubule development (GO:0072170)4.25911956
16retina layer formation (GO:0010842)4.18804547
17antigen processing and presentation of endogenous antigen (GO:0019883)4.17421465
18positive regulation of gamma-delta T cell activation (GO:0046645)4.15144910
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.09075655
20limb bud formation (GO:0060174)4.08261211
21secondary metabolite biosynthetic process (GO:0044550)4.04415674
22centriole replication (GO:0007099)4.04126438
23regulation of protein kinase A signaling (GO:0010738)4.00021520
24regulation of timing of cell differentiation (GO:0048505)4.00016871
25negative regulation of cell killing (GO:0031342)3.99808588
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.99808588
27ribosomal small subunit biogenesis (GO:0042274)3.98404914
28immunoglobulin mediated immune response (GO:0016064)3.91447876
29metanephric nephron epithelium development (GO:0072243)3.83606655
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.82837236
31NIK/NF-kappaB signaling (GO:0038061)3.77239429
32DNA methylation involved in gamete generation (GO:0043046)3.74033528
33metanephric epithelium development (GO:0072207)3.72514699
34neutrophil activation involved in immune response (GO:0002283)3.71852059
35facial nerve structural organization (GO:0021612)3.71388694
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.65660070
37regulation of development, heterochronic (GO:0040034)3.60094755
38protein heterotetramerization (GO:0051290)3.58882416
39nephron epithelium development (GO:0072009)3.56936595
40negative regulation of interleukin-12 production (GO:0032695)3.52096264
41cranial nerve morphogenesis (GO:0021602)3.49867557
42otic vesicle formation (GO:0030916)3.48860684
43response to peptidoglycan (GO:0032494)3.48724692
44regulation of protein kinase C signaling (GO:0090036)3.46257527
45mesenchymal cell differentiation involved in kidney development (GO:0072161)3.42204595
46mesenchymal cell differentiation involved in renal system development (GO:2001012)3.42204595
47response to folic acid (GO:0051593)3.41219013
48positive regulation of calcium ion import (GO:0090280)3.37933167
49neuronal action potential propagation (GO:0019227)3.36971783
50neuron cell-cell adhesion (GO:0007158)3.35798212
51modulation by symbiont of host immune response (GO:0052553)3.31434239
52positive regulation by symbiont of host defense response (GO:0052509)3.31434239
53modulation by symbiont of host defense response (GO:0052031)3.31434239
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31434239
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31434239
56positive regulation by organism of defense response of other organism involved in symbiotic interact3.31434239
57UV protection (GO:0009650)3.30785376
58cranial nerve structural organization (GO:0021604)3.30074400
59regulation of pigment cell differentiation (GO:0050932)3.28851713
60viral transcription (GO:0019083)3.28737414
61lymphoid progenitor cell differentiation (GO:0002320)3.27496980
62centriole assembly (GO:0098534)3.27166626
63negative regulation of transcription by competitive promoter binding (GO:0010944)3.26495701
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26287522
65oligodendrocyte differentiation (GO:0048709)3.24365053
66mesonephros development (GO:0001823)3.23310209
67negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.17413445
68righting reflex (GO:0060013)3.17412650
69positive regulation of cellular amine metabolic process (GO:0033240)3.10331569
70regulation of gamma-delta T cell activation (GO:0046643)3.09606469
71organ growth (GO:0035265)3.09499063
72translational termination (GO:0006415)3.09459350
73nephron tubule development (GO:0072080)3.08408869
74endothelium development (GO:0003158)3.07217496
75photoreceptor cell differentiation (GO:0046530)3.06415289
76eye photoreceptor cell differentiation (GO:0001754)3.06415289
77Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06218814
78cellular response to type I interferon (GO:0071357)3.05258305
79type I interferon signaling pathway (GO:0060337)3.05258305
80GPI anchor biosynthetic process (GO:0006506)3.04438923
81cytidine deamination (GO:0009972)3.04319493
82cytidine metabolic process (GO:0046087)3.04319493
83cytidine catabolic process (GO:0006216)3.04319493
84B cell mediated immunity (GO:0019724)3.03358391
85response to type I interferon (GO:0034340)3.03289021
86keratinocyte development (GO:0003334)2.97931674
87detection of bacterium (GO:0016045)2.96688775
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.96250366
89DNA ligation (GO:0006266)2.93012202
90regulation of cellular extravasation (GO:0002691)2.92744358
91proteasome assembly (GO:0043248)2.91435206
92omega-hydroxylase P450 pathway (GO:0097267)2.90030989
93negative regulation of phagocytosis (GO:0050765)2.89045079
94leukocyte aggregation (GO:0070486)2.87929471
95long-chain fatty acid biosynthetic process (GO:0042759)2.87648503
96regulation of B cell receptor signaling pathway (GO:0050855)2.85544142
97interkinetic nuclear migration (GO:0022027)2.84945560
98neutrophil activation (GO:0042119)2.83402631
99detection of other organism (GO:0098543)2.83013818
100regulation of gamma-delta T cell differentiation (GO:0045586)2.82500128
101positive regulation of antigen processing and presentation (GO:0002579)2.80741557
102negative regulation of myeloid cell apoptotic process (GO:0033033)2.80398195
103positive regulation of B cell differentiation (GO:0045579)2.79401226
104developmental pigmentation (GO:0048066)2.79217903
105cotranslational protein targeting to membrane (GO:0006613)2.78476181
106positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78241018
107regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77678972
108regulation of T cell mediated cytotoxicity (GO:0001914)2.77452389
109granulocyte activation (GO:0036230)2.76334576
110interferon-gamma-mediated signaling pathway (GO:0060333)2.75420597
111regulation of keratinocyte proliferation (GO:0010837)2.75149279
112defense response to protozoan (GO:0042832)2.75075695
113regulation of antigen processing and presentation (GO:0002577)2.74930294
114protein targeting to ER (GO:0045047)2.74439038
115SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.73821344
116histone H2B ubiquitination (GO:0033523)2.73158717
117regulation of mast cell degranulation (GO:0043304)2.72857207
118enteric nervous system development (GO:0048484)2.72126436
119renal tubule development (GO:0061326)2.71407254
120negative regulation of innate immune response (GO:0045824)2.71173927
121regulation of execution phase of apoptosis (GO:1900117)2.70391381
122cellular response to interleukin-15 (GO:0071350)2.69593242
123GPI anchor metabolic process (GO:0006505)2.69459384
124negative regulation of protein localization to cell surface (GO:2000009)2.68653323
125pyrimidine ribonucleoside catabolic process (GO:0046133)2.68377372
126pattern specification involved in kidney development (GO:0061004)2.67528541
127response to protozoan (GO:0001562)2.67416086
128myelination (GO:0042552)2.66195103
129macrophage activation involved in immune response (GO:0002281)2.65094599
130response to muramyl dipeptide (GO:0032495)2.64046054
131cerebral cortex radially oriented cell migration (GO:0021799)2.63349708
132myeloid dendritic cell activation (GO:0001773)2.62592511
133establishment of protein localization to endoplasmic reticulum (GO:0072599)2.62419006
134cranial nerve development (GO:0021545)2.62384389
135myeloid cell activation involved in immune response (GO:0002275)2.61856011
136positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.61692970
137sympathetic nervous system development (GO:0048485)2.61631202
138ensheathment of neurons (GO:0007272)2.61233586
139axon ensheathment (GO:0008366)2.61233586
140respiratory burst (GO:0045730)2.61083372
141polyol transport (GO:0015791)2.58972612
142DNA damage response, detection of DNA damage (GO:0042769)2.58439341
143regulation of dendritic cell antigen processing and presentation (GO:0002604)2.58136414
144regulation of somitogenesis (GO:0014807)2.56289272
145protein localization to endoplasmic reticulum (GO:0070972)2.56176943
146positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.55532945
147negative regulation of myoblast differentiation (GO:0045662)2.55449552
148regulation of alpha-beta T cell proliferation (GO:0046640)2.55264467
149tolerance induction (GO:0002507)2.54371242
150regulation of interferon-beta biosynthetic process (GO:0045357)2.54201959
151cell proliferation in forebrain (GO:0021846)2.54049478
152negative thymic T cell selection (GO:0045060)2.52764772
153amino sugar catabolic process (GO:0046348)2.52606624
154photoreceptor cell maintenance (GO:0045494)2.52057099
155mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.49705912
156negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.49701004
157negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.49511089
158maturation of SSU-rRNA (GO:0030490)2.49497921
159actin nucleation (GO:0045010)2.49254226
160response to interleukin-15 (GO:0070672)2.49244678
161lipopolysaccharide-mediated signaling pathway (GO:0031663)2.49022272
162spinal cord motor neuron differentiation (GO:0021522)2.48983887
163positive thymic T cell selection (GO:0045059)2.48531195
164collecting duct development (GO:0072044)2.48499936
165sphingoid metabolic process (GO:0046519)2.48153319
166negative T cell selection (GO:0043383)2.47174843
167leukocyte degranulation (GO:0043299)2.46811716
168regulation of B cell differentiation (GO:0045577)2.46157925
169fatty acid elongation (GO:0030497)2.44582665
170DNA double-strand break processing (GO:0000729)2.44021267
171deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.42946989
172regulation of mast cell activation involved in immune response (GO:0033006)2.42933550
173negative regulation of lymphocyte mediated immunity (GO:0002707)2.42442932
174branch elongation of an epithelium (GO:0060602)2.42076173
175regulation of natural killer cell mediated immunity (GO:0002715)2.42074164
176regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.42074164
177response to interferon-beta (GO:0035456)2.41802605
178negative regulation of cytokine production involved in immune response (GO:0002719)2.40392752
179positive regulation of synapse assembly (GO:0051965)2.39639559
180mast cell activation (GO:0045576)2.39275923
181regulation of mast cell activation (GO:0033003)2.39116604
182DNA deamination (GO:0045006)2.38604389
183positive regulation of interleukin-17 production (GO:0032740)2.37691859
184myeloid dendritic cell differentiation (GO:0043011)2.37191571
185regulation of leukocyte mediated cytotoxicity (GO:0001910)2.36818699
186regulation of T cell tolerance induction (GO:0002664)2.36264471
187regulation of B cell apoptotic process (GO:0002902)2.35951507
188positive regulation of isotype switching (GO:0045830)2.35202339
189angiotensin maturation (GO:0002003)2.35060422
190chaperone mediated protein folding requiring cofactor (GO:0051085)2.33976778
191regulation of vitamin metabolic process (GO:0030656)2.31883887
192antigen processing and presentation via MHC class Ib (GO:0002475)2.30334840
193metallo-sulfur cluster assembly (GO:0031163)2.30252821
194iron-sulfur cluster assembly (GO:0016226)2.30252821
195cellular response to zinc ion (GO:0071294)2.29842116
196negative regulation of T cell mediated immunity (GO:0002710)2.29561855
197T-helper 1 type immune response (GO:0042088)2.29205218
198regulation of interleukin-2 biosynthetic process (GO:0045076)2.28921716
199T cell costimulation (GO:0031295)2.27817172
200positive regulation of lymphocyte migration (GO:2000403)2.27494667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41028978
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.44203340
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.14950173
4GBX2_23144817_ChIP-Seq_PC3_Human2.92688092
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.88281903
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82011368
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.81361131
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67330770
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.64126149
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.60927547
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.57882347
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.57563935
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57034867
14VDR_21846776_ChIP-Seq_THP-1_Human2.54396918
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51585837
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.50376127
17TAF15_26573619_Chip-Seq_HEK293_Human2.48461066
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48451610
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45998881
20VDR_22108803_ChIP-Seq_LS180_Human2.43511197
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.41681838
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33322811
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28574880
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22923726
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22610931
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.19628064
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19289259
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16710699
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16689219
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15037948
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13238369
32MYC_22102868_ChIP-Seq_BL_Human2.12881714
33SPI1_23547873_ChIP-Seq_NB4_Human2.10955897
34IGF1R_20145208_ChIP-Seq_DFB_Human2.10569585
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08281665
36EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08124228
37RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08124228
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07767403
39JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07256963
40RNF2_27304074_Chip-Seq_NSC_Mouse2.06978696
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06848449
42IRF1_19129219_ChIP-ChIP_H3396_Human2.05875573
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05380956
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05090972
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04490212
46SUZ12_27294783_Chip-Seq_NPCs_Mouse2.03398731
47POU5F1_16153702_ChIP-ChIP_HESCs_Human2.02656891
48STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00101234
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99543861
50AR_21572438_ChIP-Seq_LNCaP_Human1.98090080
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.95369723
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.92978831
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91870892
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.88638268
55VDR_24763502_ChIP-Seq_THP-1_Human1.82905331
56MAF_26560356_Chip-Seq_TH1_Human1.82356810
57UTX_26944678_Chip-Seq_JUKART_Human1.81982547
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.78394168
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77277606
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74982297
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74329229
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72467291
63MYB_26560356_Chip-Seq_TH2_Human1.72319634
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.72148127
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.72148127
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.72148127
67BCL6_27268052_Chip-Seq_Bcells_Human1.71160248
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70929853
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69898669
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66541596
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.65433564
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61881032
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60278395
74MAF_26560356_Chip-Seq_TH2_Human1.58785038
75ER_23166858_ChIP-Seq_MCF-7_Human1.58169147
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57358311
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.56845267
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.56643064
79MYB_26560356_Chip-Seq_TH1_Human1.55308735
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.55074162
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.54864382
82SCL_19346495_ChIP-Seq_HPC-7_Human1.54409042
83LXR_22292898_ChIP-Seq_THP-1_Human1.53413062
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53221630
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52261980
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51738991
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.49026285
88BCOR_27268052_Chip-Seq_Bcells_Human1.47743984
89FUS_26573619_Chip-Seq_HEK293_Human1.46687203
90P300_18555785_Chip-Seq_ESCs_Mouse1.45566652
91P53_22387025_ChIP-Seq_ESCs_Mouse1.44858034
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44677090
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44614493
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.43376794
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43138675
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42927601
97CIITA_25753668_ChIP-Seq_RAJI_Human1.42584396
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41793946
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41770443
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41634614
101P300_19829295_ChIP-Seq_ESCs_Human1.41339587
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41306896
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.40582823
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.39520834
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37034978
106SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35944691
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35498154
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34148917
109NMYC_18555785_Chip-Seq_ESCs_Mouse1.34139484
110MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34017627
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.33764897
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.33204228
113SPI1_23127762_ChIP-Seq_K562_Human1.30929133
114MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30660687
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30615962
116BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30346363
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.29939965
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.29342635
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28284725
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.27355454
121SRF_21415370_ChIP-Seq_HL-1_Mouse1.27348675
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26845716
123MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26496682
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26393080
125HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26251776
126GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25939660
127CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25545251
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25445492
129GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25381023
130GABP_19822575_ChIP-Seq_HepG2_Human1.24644935
131KLF4_18555785_Chip-Seq_ESCs_Mouse1.24099926
132ETS1_20019798_ChIP-Seq_JURKAT_Human1.23883523
133PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23808682
134SMAD3_21741376_ChIP-Seq_EPCs_Human1.23280978
135TET1_21451524_ChIP-Seq_MESCs_Mouse1.20930633
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19774661
137SOX2_18555785_Chip-Seq_ESCs_Mouse1.19643679
138ZFX_18555785_Chip-Seq_ESCs_Mouse1.19188417
139P68_20966046_ChIP-Seq_HELA_Human1.18896521
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18574832
141PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18463490
142EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18388480
143DCP1A_22483619_ChIP-Seq_HELA_Human1.18046048
144OCT4_18555785_Chip-Seq_ESCs_Mouse1.17464124
145FOXP3_21729870_ChIP-Seq_TREG_Human1.14910315
146KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14718349
147RUNX_20019798_ChIP-Seq_JUKART_Human1.14487085
148CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14240038
149SMAD1_18555785_Chip-Seq_ESCs_Mouse1.14151812
150VDR_23849224_ChIP-Seq_CD4+_Human1.12907784
151ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12248643
152ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11967574
153PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11755428
154PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11376070
155CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11295730
156GATA3_27048872_Chip-Seq_THYMUS_Human1.10754236
157CTCF_26484167_Chip-Seq_Bcells_Mouse1.10504486
158GABP_17652178_ChIP-ChIP_JURKAT_Human1.10191509
159HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09016276
160SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08888202
161YY1_22570637_ChIP-Seq_MALME-3M_Human1.08693070
162CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08510666
163CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08410247
164CRX_20693478_ChIP-Seq_RETINA_Mouse1.08152415
165PU1_27457419_Chip-Seq_LIVER_Mouse1.07398534
166STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06833476
167OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06709731
168UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06579386
169PHF8_20622854_ChIP-Seq_HELA_Human1.06391121
170CTCF_18555785_Chip-Seq_ESCs_Mouse1.06110420
171STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06068339
172P300_27268052_Chip-Seq_Bcells_Human1.05486342
173E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05124205
174SA1_27219007_Chip-Seq_ERYTHROID_Human1.04658347
175RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04655160
176STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04254095
177CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04094809
178E2F1_20622854_ChIP-Seq_HELA_Human1.03931719
179NOTCH1_21737748_ChIP-Seq_TLL_Human1.02075211
180RING1B_27294783_Chip-Seq_NPCs_Mouse1.01468018
181CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01353918
182BP1_19119308_ChIP-ChIP_Hs578T_Human1.00714469
183SMAD_19615063_ChIP-ChIP_OVARY_Human0.99840506
184GATA1_19941827_ChIP-Seq_MEL_Mouse0.99440761
185TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99426485
186SMAD4_21799915_ChIP-Seq_A2780_Human0.98378288
187WT1_19549856_ChIP-ChIP_CCG9911_Human0.97850588
188THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97695275
189RUNX2_22187159_ChIP-Seq_PCA_Human0.97590137
190TCF7_22412390_ChIP-Seq_EML_Mouse0.97160834
191SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97116622
192KDM2B_26808549_Chip-Seq_REH_Human0.96882333
193CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95230918
194EWS_26573619_Chip-Seq_HEK293_Human0.94457448
195LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94114345
196RING1B_27294783_Chip-Seq_ESCs_Mouse0.92466175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.76197949
2MP0005409_darkened_coat_color6.14731774
3MP0001188_hyperpigmentation5.90288194
4MP0004381_abnormal_hair_follicle5.18906423
5MP0003436_decreased_susceptibility_to3.49664793
6MP0009379_abnormal_foot_pigmentation3.35462242
7MP0005671_abnormal_response_to3.28322751
8MP0006292_abnormal_olfactory_placode3.24315547
9MP0005174_abnormal_tail_pigmentation3.20674010
10MP0001835_abnormal_antigen_presentation3.16847152
11MP0003880_abnormal_central_pattern3.07550964
12MP0003806_abnormal_nucleotide_metabolis3.06675884
13MP0000015_abnormal_ear_pigmentation2.94706684
14MP0009785_altered_susceptibility_to2.92425444
15MP0003303_peritoneal_inflammation2.73671551
16MP0006082_CNS_inflammation2.70139918
17MP0005000_abnormal_immune_tolerance2.63824927
18MP0005025_abnormal_response_to2.60919677
19MP0002419_abnormal_innate_immunity2.45356692
20MP0002148_abnormal_hypersensitivity_rea2.45113426
21MP0001800_abnormal_humoral_immune2.44862841
22MP0005360_urolithiasis2.40747870
23MP0003763_abnormal_thymus_physiology2.38401535
24MP0001790_abnormal_immune_system2.37850469
25MP0005387_immune_system_phenotype2.37850469
26MP0000685_abnormal_immune_system2.37666605
27MP0002102_abnormal_ear_morphology2.27961659
28MP0002723_abnormal_immune_serum2.26685305
29MP0002452_abnormal_antigen_presenting2.23999681
30MP0010155_abnormal_intestine_physiology2.22450531
31MP0000566_synostosis2.22264303
32MP0002420_abnormal_adaptive_immunity2.19022607
33MP0001819_abnormal_immune_cell2.18061425
34MP0005058_abnormal_lysosome_morphology2.15241293
35MP0004742_abnormal_vestibular_system2.14653949
36MP0009840_abnormal_foam_cell2.11289702
37MP0009333_abnormal_splenocyte_physiolog2.05506687
38MP0002132_abnormal_respiratory_system2.05481181
39MP0003300_gastrointestinal_ulcer1.96529465
40MP0000465_gastrointestinal_hemorrhage1.84404990
41MP0005464_abnormal_platelet_physiology1.80277286
42MP0001845_abnormal_inflammatory_respons1.78638760
43MP0003866_abnormal_defecation1.75095809
44MP0002139_abnormal_hepatobiliary_system1.75090451
45MP0001873_stomach_inflammation1.74238711
46MP0002398_abnormal_bone_marrow1.72835925
47MP0003183_abnormal_peptide_metabolism1.71036026
48MP0000716_abnormal_immune_system1.71020939
49MP0001968_abnormal_touch/_nociception1.70974227
50MP0001533_abnormal_skeleton_physiology1.70578213
51MP0002405_respiratory_system_inflammati1.68535433
52MP0003938_abnormal_ear_development1.68198939
53MP0002249_abnormal_larynx_morphology1.64307333
54MP0009278_abnormal_bone_marrow1.62143821
55MP0002277_abnormal_respiratory_mucosa1.60775567
56MP0009764_decreased_sensitivity_to1.58325338
57MP0003724_increased_susceptibility_to1.58277348
58MP0008469_abnormal_protein_level1.57938403
59MP0000689_abnormal_spleen_morphology1.57550107
60MP0001545_abnormal_hematopoietic_system1.56886368
61MP0005397_hematopoietic_system_phenotyp1.56886368
62MP0004947_skin_inflammation1.56326805
63MP0002722_abnormal_immune_system1.56205270
64MP0005423_abnormal_somatic_nervous1.53115736
65MP0002177_abnormal_outer_ear1.49267777
66MP0004142_abnormal_muscle_tone1.48915221
67MP0002254_reproductive_system_inflammat1.48546327
68MP0002429_abnormal_blood_cell1.47912082
69MP0005171_absent_coat_pigmentation1.46016479
70MP0000049_abnormal_middle_ear1.41242574
71MP0000490_abnormal_crypts_of1.41108919
72MP0003315_abnormal_perineum_morphology1.40940120
73MP0002095_abnormal_skin_pigmentation1.40140608
74MP0004147_increased_porphyrin_level1.36116873
75MP0003172_abnormal_lysosome_physiology1.35589453
76MP0003941_abnormal_skin_development1.32569883
77MP0005310_abnormal_salivary_gland1.32466608
78MP0008260_abnormal_autophagy1.32343266
79MP0003191_abnormal_cellular_cholesterol1.31322556
80MP0001486_abnormal_startle_reflex1.30829175
81MP0000858_altered_metastatic_potential1.27899197
82MP0000703_abnormal_thymus_morphology1.27494559
83MP0003718_maternal_effect1.24323947
84MP0000920_abnormal_myelination1.23165187
85MP0002396_abnormal_hematopoietic_system1.22057883
86MP0002638_abnormal_pupillary_reflex1.20098286
87MP0003656_abnormal_erythrocyte_physiolo1.18021985
88MP0002138_abnormal_hepatobiliary_system1.17658448
89MP0003011_delayed_dark_adaptation1.16943053
90MP0005166_decreased_susceptibility_to1.16613378
91MP0005365_abnormal_bile_salt1.15491661
92MP0009250_abnormal_appendicular_skeleto1.13269095
93MP0001764_abnormal_homeostasis1.11659487
94MP0004510_myositis1.11575741
95MP0006036_abnormal_mitochondrial_physio1.10252691
96MP0005551_abnormal_eye_electrophysiolog1.09037592
97MP0001986_abnormal_taste_sensitivity1.08543950
98MP0002166_altered_tumor_susceptibility1.07683529
99MP0002272_abnormal_nervous_system1.07664993
100MP0000631_abnormal_neuroendocrine_gland1.07047661
101MP0000026_abnormal_inner_ear1.06633108
102MP0003075_altered_response_to1.05646852
103MP0009763_increased_sensitivity_to1.04202118
104MP0002067_abnormal_sensory_capabilities1.03413621
105MP0003937_abnormal_limbs/digits/tail_de1.03195010
106MP0001663_abnormal_digestive_system1.02982831
107MP0000778_abnormal_nervous_system1.02922634
108MP0005085_abnormal_gallbladder_physiolo1.01258436
109MP0000579_abnormal_nail_morphology1.01216093
110MP0005075_abnormal_melanosome_morpholog0.99897036
111MP0002751_abnormal_autonomic_nervous0.99360287
112MP0000762_abnormal_tongue_morphology0.98468213
113MP0005379_endocrine/exocrine_gland_phen0.97669569
114MP0000613_abnormal_salivary_gland0.96559037
115MP0000343_altered_response_to0.95908923
116MP0001346_abnormal_lacrimal_gland0.95380425
117MP0001905_abnormal_dopamine_level0.93226305
118MP0008004_abnormal_stomach_pH0.93095154
119MP0002752_abnormal_somatic_nervous0.92494887
120MP0003693_abnormal_embryo_hatching0.92156051
121MP0001970_abnormal_pain_threshold0.91680395
122MP0006072_abnormal_retinal_apoptosis0.90451372
123MP0000609_abnormal_liver_physiology0.88257978
124MP0001485_abnormal_pinna_reflex0.87594408
125MP0005319_abnormal_enzyme/_coenzyme0.86649604
126MP0008995_early_reproductive_senescence0.86612967
127MP0002938_white_spotting0.86562699
128MP0006276_abnormal_autonomic_nervous0.86356500
129MP0006035_abnormal_mitochondrial_morpho0.84980838
130MP0005083_abnormal_biliary_tract0.84451825
131MP0001666_abnormal_nutrient_absorption0.83636111
132MP0002998_abnormal_bone_remodeling0.82438126
133MP0001340_abnormal_eyelid_morphology0.81813009
134MP0004264_abnormal_extraembryonic_tissu0.81565474
135MP0001963_abnormal_hearing_physiology0.80508977
136MP0005595_abnormal_vascular_smooth0.80377273
137MP0004133_heterotaxia0.80243113
138MP0009765_abnormal_xenobiotic_induced0.79679838
139MP0009745_abnormal_behavioral_response0.79256362
140MP0002933_joint_inflammation0.77675792
141MP0005451_abnormal_body_composition0.77559914
142MP0003950_abnormal_plasma_membrane0.77225250
143MP0000467_abnormal_esophagus_morphology0.76584854
144MP0002019_abnormal_tumor_incidence0.73675068
145MP0000383_abnormal_hair_follicle0.73434190
146MP0001853_heart_inflammation0.72546449
147MP0002006_tumorigenesis0.72268639
148MP0004019_abnormal_vitamin_homeostasis0.71486694
149MP0002734_abnormal_mechanical_nocicepti0.70271507
150MP0001286_abnormal_eye_development0.69983646
151MP0005636_abnormal_mineral_homeostasis0.69306122
152MP0001661_extended_life_span0.69236111
153MP0009643_abnormal_urine_homeostasis0.69054245
154MP0009046_muscle_twitch0.68581244
155MP0004145_abnormal_muscle_electrophysio0.67643816
156MP0005584_abnormal_enzyme/coenzyme_acti0.67591211
157MP0005195_abnormal_posterior_eye0.67039575
158MP0000604_amyloidosis0.66117998
159MP0003186_abnormal_redox_activity0.65524055
160MP0002163_abnormal_gland_morphology0.65189532
161MP0000462_abnormal_digestive_system0.63679574
162MP0002233_abnormal_nose_morphology0.63055876
163MP0002064_seizures0.62364639
164MP0005390_skeleton_phenotype0.61966150
165MP0002876_abnormal_thyroid_physiology0.61673220
166MP0003755_abnormal_palate_morphology0.61283981
167MP0004270_analgesia0.60664173
168MP0003448_altered_tumor_morphology0.60486749
169MP0005165_increased_susceptibility_to0.59941608
170MP0003786_premature_aging0.59055804
171MP0002557_abnormal_social/conspecific_i0.58242453
172MP0005253_abnormal_eye_physiology0.58221805
173MP0005167_abnormal_blood-brain_barrier0.57227919
174MP0002882_abnormal_neuron_morphology0.56873276
175MP0002229_neurodegeneration0.56740335
176MP0003795_abnormal_bone_structure0.55922036
177MP0000647_abnormal_sebaceous_gland0.54890761
178MP0002098_abnormal_vibrissa_morphology0.54595928
179MP0002184_abnormal_innervation0.53762751
180MP0002282_abnormal_trachea_morphology0.53034090
181MP0001529_abnormal_vocalization0.52096308
182MP0003828_pulmonary_edema0.52014312
183MP0005381_digestive/alimentary_phenotyp0.50734151
184MP0005645_abnormal_hypothalamus_physiol0.50205752
185MP0005391_vision/eye_phenotype0.49902403
186MP0001299_abnormal_eye_distance/0.49572837
187MP0000432_abnormal_head_morphology0.48868269
188MP0000681_abnormal_thyroid_gland0.48547847
189MP0001664_abnormal_digestion0.48437070
190MP0003635_abnormal_synaptic_transmissio0.47228670
191MP0005164_abnormal_response_to0.46717853
192MP0003385_abnormal_body_wall0.45494634
193MP0008569_lethality_at_weaning0.44995877

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the axillary hair (HP:0100134)6.26178989
2Abnormality of secondary sexual hair (HP:0009888)6.26178989
3Sex reversal (HP:0012245)5.68364850
4Abnormal sex determination (HP:0012244)5.68364850
5Obstructive sleep apnea (HP:0002870)4.28667799
6Petechiae (HP:0000967)4.02127446
7Eczematoid dermatitis (HP:0000976)3.98159845
8Recurrent abscess formation (HP:0002722)3.96139231
9Elevated erythrocyte sedimentation rate (HP:0003565)3.91482531
10Septo-optic dysplasia (HP:0100842)3.90617105
11Myositis (HP:0100614)3.85517272
12Abnormality of macrophages (HP:0004311)3.72207590
13Recurrent bacterial skin infections (HP:0005406)3.65456064
14Recurrent fungal infections (HP:0002841)3.60863176
15Attenuation of retinal blood vessels (HP:0007843)3.47869094
16Orchitis (HP:0100796)3.47137431
17Optic nerve hypoplasia (HP:0000609)3.46871957
18Mediastinal lymphadenopathy (HP:0100721)3.38678040
19Absent septum pellucidum (HP:0001331)3.32516865
20Split foot (HP:0001839)3.24048237
21Increased IgM level (HP:0003496)3.19995984
22Abnormality of the septum pellucidum (HP:0007375)3.12408432
23Parakeratosis (HP:0001036)3.10895658
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.10617839
25Chronic mucocutaneous candidiasis (HP:0002728)3.10106595
26Recurrent cutaneous fungal infections (HP:0011370)3.10106595
27Retrobulbar optic neuritis (HP:0100654)3.09679820
28Optic neuritis (HP:0100653)3.09679820
29Encephalitis (HP:0002383)3.09562049
30Alacrima (HP:0000522)3.04990556
31Chronic obstructive pulmonary disease (HP:0006510)3.02302858
32Obstructive lung disease (HP:0006536)3.02302858
33Increased serum ferritin (HP:0003281)2.98401959
34Granulocytopenia (HP:0001913)2.98290915
35Abnormality of glycolipid metabolism (HP:0010969)2.97281332
36Abnormality of liposaccharide metabolism (HP:0010968)2.97281332
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.97281332
38Pustule (HP:0200039)2.96725114
39Meningitis (HP:0001287)2.93803382
40Abnormal biliary tract physiology (HP:0012439)2.91602630
41Bile duct proliferation (HP:0001408)2.91602630
42Recurrent viral infections (HP:0004429)2.88301874
43Panhypogammaglobulinemia (HP:0003139)2.87280280
44Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.83939870
45Optic disc pallor (HP:0000543)2.83764548
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.81582155
47Concave nail (HP:0001598)2.80597142
48Supernumerary spleens (HP:0009799)2.77527072
49Recurrent skin infections (HP:0001581)2.74858461
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.73035340
51Systemic lupus erythematosus (HP:0002725)2.72797585
52Vacuolated lymphocytes (HP:0001922)2.72572038
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.68929263
54Absent/shortened dynein arms (HP:0200106)2.68929263
55Absent speech (HP:0001344)2.68443644
56Peripheral hypomyelination (HP:0007182)2.66984087
57Abnormality of T cells (HP:0002843)2.64724358
58Decreased lacrimation (HP:0000633)2.64097403
59Abnormality of T cell physiology (HP:0011840)2.63952777
60Sleep apnea (HP:0010535)2.62972692
61Vasculitis (HP:0002633)2.62741374
62Chronic diarrhea (HP:0002028)2.62562522
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.62206038
64Reticulocytopenia (HP:0001896)2.60665278
65Abnormality of iron homeostasis (HP:0011031)2.60407188
66Eosinophilia (HP:0001880)2.57372287
67Gonadal dysgenesis (HP:0000133)2.57057458
68Recurrent gram-negative bacterial infections (HP:0005420)2.53804721
69Thyroid-stimulating hormone excess (HP:0002925)2.52455213
70Abnormal ciliary motility (HP:0012262)2.52066648
71Inflammation of the large intestine (HP:0002037)2.50681761
72Loss of speech (HP:0002371)2.50656881
73Urticaria (HP:0001025)2.49923865
74Gastrointestinal inflammation (HP:0004386)2.49102066
75Increased cerebral lipofuscin (HP:0011813)2.48034987
76White forelock (HP:0002211)2.47892911
77Leukocytosis (HP:0001974)2.45625777
78Nonprogressive disorder (HP:0003680)2.45520309
79Patchy hypopigmentation of hair (HP:0011365)2.45173187
80Prolonged bleeding time (HP:0003010)2.44496409
81IgG deficiency (HP:0004315)2.42270518
82Cerebral palsy (HP:0100021)2.41433643
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41361044
84Autoimmune thrombocytopenia (HP:0001973)2.41353120
85Male pseudohermaphroditism (HP:0000037)2.39871050
86Increased IgE level (HP:0003212)2.39603824
87Hepatosplenomegaly (HP:0001433)2.38158148
88Abnormal respiratory motile cilium morphology (HP:0005938)2.36943438
89Abnormal respiratory epithelium morphology (HP:0012253)2.36943438
90IgM deficiency (HP:0002850)2.32052740
91Abnormality of B cell number (HP:0010975)2.31503993
92Abnormality of cells of the erythroid lineage (HP:0012130)2.30944827
93Esotropia (HP:0000565)2.30387371
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.30286961
95Keratoconjunctivitis (HP:0001096)2.28257157
96Asplenia (HP:0001746)2.27962301
97Macrocytic anemia (HP:0001972)2.27522655
98Episodic fever (HP:0001954)2.27064946
99Purpura (HP:0000979)2.26862502
100Abnormality of transition element cation homeostasis (HP:0011030)2.26773896
101Gastrointestinal infarctions (HP:0005244)2.25728142
102Hypergammaglobulinemia (HP:0010702)2.25256596
103Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24847054
104Agammaglobulinemia (HP:0004432)2.23677624
105Dicarboxylic aciduria (HP:0003215)2.23450403
106Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23450403
107Hepatocellular necrosis (HP:0001404)2.23347754
108Anorexia (HP:0002039)2.22148380
109T lymphocytopenia (HP:0005403)2.21944180
110Abnormality of eosinophils (HP:0001879)2.21348266
111Abnormality of T cell number (HP:0011839)2.21018000
112Short tibia (HP:0005736)2.20454648
113Spontaneous hematomas (HP:0007420)2.19911989
114Colitis (HP:0002583)2.19621106
115Aplasia/Hypoplasia of the tibia (HP:0005772)2.18753430
116Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18575327
117Abnormal respiratory motile cilium physiology (HP:0012261)2.17595444
118Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15771543
119Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15771543
120Abnormal number of erythroid precursors (HP:0012131)2.15152197
121Lymphopenia (HP:0001888)2.14245133
122Ragged-red muscle fibers (HP:0003200)2.13300000
123Hemoptysis (HP:0002105)2.13138943
124Pulmonary infiltrates (HP:0002113)2.13030079
125Epistaxis (HP:0000421)2.12756655
126Acute hepatic failure (HP:0006554)2.09381679
127Hypoplasia of the radius (HP:0002984)2.08919556
128Dysostosis multiplex (HP:0000943)2.08275649
129Type I transferrin isoform profile (HP:0003642)2.07300890
1303-Methylglutaconic aciduria (HP:0003535)2.07077047
131Keratoconjunctivitis sicca (HP:0001097)2.06613761
132Duplicated collecting system (HP:0000081)2.06130244
133Malnutrition (HP:0004395)2.05957199
134Aplasia/Hypoplasia of the spleen (HP:0010451)2.04834841
135Skin rash (HP:0000988)2.04737494
136Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04035843
137Ocular albinism (HP:0001107)2.03778047
138Severe combined immunodeficiency (HP:0004430)2.02082122
139Abnormality of cells of the lymphoid lineage (HP:0012140)2.01801911
140Chin dimple (HP:0010751)2.01428560
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01426257
142Laryngomalacia (HP:0001601)2.01371025
143Hepatic necrosis (HP:0002605)2.00728750
144Renal agenesis (HP:0000104)2.00373281
145Chromsome breakage (HP:0040012)1.98938503
146Abnormality of the prostate (HP:0008775)1.97821633
147Hematochezia (HP:0002573)1.97359381
148Duplication of thumb phalanx (HP:0009942)1.96795417
149Conical tooth (HP:0000698)1.96457412
150Aplasia/hypoplasia of the uterus (HP:0008684)1.96145582
151Hypoplasia of the ulna (HP:0003022)1.95789454
152Joint swelling (HP:0001386)1.95438783
153Abnormality of polysaccharide metabolism (HP:0011012)1.94166378
154Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94166378
155Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94166378
156Decreased central vision (HP:0007663)1.93783850
157Progressive neurologic deterioration (HP:0002344)1.93117881
158Combined immunodeficiency (HP:0005387)1.92714187
159Increased muscle lipid content (HP:0009058)1.92383674
160Congenital sensorineural hearing impairment (HP:0008527)1.91562908
161Absent forearm bone (HP:0003953)1.90480500
162Aplasia involving forearm bones (HP:0009822)1.90480500
163Abnormality of magnesium homeostasis (HP:0004921)1.90339312
164B lymphocytopenia (HP:0010976)1.90112629
165Partial duplication of thumb phalanx (HP:0009944)1.89873808
166Autoimmune hemolytic anemia (HP:0001890)1.89461267
167Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89435999
168Hypochromic anemia (HP:0001931)1.88795365
169Nephronophthisis (HP:0000090)1.88014867
170Increased hepatocellular lipid droplets (HP:0006565)1.87728046
171Broad-based gait (HP:0002136)1.87385905
172Degeneration of the lateral corticospinal tracts (HP:0002314)1.87306696
173Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87306696
174Chest pain (HP:0100749)1.86924621
175Absent radius (HP:0003974)1.86868978
176True hermaphroditism (HP:0010459)1.86711934
177Renal Fanconi syndrome (HP:0001994)1.86173997
178Aplasia/Hypoplasia of the ulna (HP:0006495)1.85382589
179Iris hypopigmentation (HP:0007730)1.84740562
180Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.84212911
181Aplasia cutis congenita (HP:0001057)1.83374297
182Hypomagnesemia (HP:0002917)1.83040912
183Abnormality of the renal collecting system (HP:0004742)1.82353113
184Prolonged neonatal jaundice (HP:0006579)1.79512842
185Upper limb muscle weakness (HP:0003484)1.78970330
186Triphalangeal thumb (HP:0001199)1.77257685
187Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76656613
188Morphological abnormality of the inner ear (HP:0011390)1.76154094
189Pallor (HP:0000980)1.75772205
190Amelogenesis imperfecta (HP:0000705)1.75260166
191Focal motor seizures (HP:0011153)1.74456136
192Nasolacrimal duct obstruction (HP:0000579)1.74417193
193Anomalous pulmonary venous return (HP:0010772)1.74345176
194Partial duplication of the phalanx of hand (HP:0009999)1.73240268
195Abnormality of the pulmonary veins (HP:0011718)1.72552506
196Stomatitis (HP:0010280)1.72416990
197Sensory axonal neuropathy (HP:0003390)1.71440174
198Overfolded helix (HP:0000396)1.70157529
199Hypophosphatemic rickets (HP:0004912)1.69748928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK9.98439923
2MAP4K13.93781919
3TESK23.84999448
4MKNK23.67709472
5ERN13.07588080
6TLK12.85596517
7PHKG22.83442340
8PHKG12.83442340
9TNIK2.55149315
10KDR2.53520831
11BCKDK2.48181425
12STK162.42973685
13MAP3K112.32341058
14TYK22.22635799
15TESK12.20410740
16RIPK42.19175735
17MKNK12.17955198
18GRK62.15289348
19TBK12.07876703
20MUSK2.01063507
21VRK21.97666250
22PIM21.96003381
23BLK1.94401101
24MAP2K31.88691132
25STK391.82493901
26IKBKB1.81287396
27SRPK11.80441747
28CLK11.77187151
29MATK1.74219681
30ZAP701.73315108
31GRK11.69858058
32IRAK41.67810481
33FES1.54079706
34SMG11.52779457
35TAOK31.51708969
36BTK1.49194072
37IRAK21.47942285
38TAOK21.44794294
39PKN11.43010354
40NLK1.42680406
41IRAK11.38505301
42JAK31.38192094
43SYK1.34812666
44SIK31.27923936
45MAP3K31.25434877
46MARK31.25328639
47OXSR11.25208735
48TNK21.25141263
49NME21.22925787
50TAOK11.20840068
51MAPK151.18979304
52EIF2AK21.14209774
53ITK1.13658319
54CSF1R1.12220002
55MAP3K131.09609158
56PBK1.07934642
57STK101.07809879
58FGR1.03861002
59IRAK31.01586587
60MAP4K21.01407623
61EIF2AK30.99345478
62YES10.98447068
63SCYL20.97079486
64BMPR1B0.94456599
65PINK10.93283467
66INSRR0.91293614
67ADRBK20.91169108
68GRK70.88875783
69CDK30.88603825
70BUB10.88590501
71VRK10.87706540
72HCK0.87514127
73UHMK10.86779192
74PRKG20.86523732
75MAPKAPK50.85664781
76RPS6KA40.85359270
77CDK190.84277938
78PAK20.84172042
79DYRK20.83339525
80CSNK1G10.82796321
81NEK60.77768105
82PRKD20.76293679
83MAP3K10.75649721
84CAMK2B0.75455311
85MAPKAPK30.75450569
86PAK10.73276002
87MST40.72539496
88MAPK130.72415112
89MAPK110.72300720
90JAK10.71801648
91DAPK10.67339893
92PIK3CG0.66549739
93NME10.65897417
94DYRK1A0.62140189
95MAP3K50.61590312
96CDK40.61553406
97PRKAA20.61082585
98PRPF4B0.59327966
99NUAK10.58253867
100PNCK0.57600958
101PRKG10.56106892
102MAP3K80.55945882
103JAK20.53375660
104PIM10.53256577
105RPS6KA50.52487234
106ABL20.52035211
107NTRK30.51546524
108TXK0.50070808
109TIE10.49747565
110PAK40.48239208
111MAPKAPK20.47257036
112TEC0.46998743
113FER0.45584703
114CAMK2A0.45466623
115ACVR1B0.45334422
116CAMK10.45308314
117CAMK2D0.45099943
118HIPK20.43015127
119ARAF0.42701205
120ZAK0.41582351
121EPHB10.41164115
122WNK10.39228918
123TGFBR20.38758093
124BMPR20.38683266
125CSNK1G30.38309747
126PRKCE0.37897597
127PDK10.37750754
128WNK40.37432644
129CSK0.37323482
130CSNK1A1L0.37061926
131ROCK20.37001447
132MAP2K60.36265118
133CDK70.35465808
134MAP3K140.35025089
135EPHA30.34581676
136DYRK30.33678533
137CSNK1D0.32682766
138CHUK0.32337584
139RAF10.32139445
140LIMK10.31248552
141IKBKE0.31139225
142CAMK2G0.30896935
143EPHA40.30602812
144FGFR40.30447419
145RPS6KL10.30382936
146RPS6KC10.30382936
147AKT30.29995358
148MAP2K20.29575762
149LYN0.29400211
150LCK0.28869329
151GSK3A0.28603503
152TRIB30.28504551
153PDPK10.27653746
154MAP2K70.26472966
155CSNK2A20.25095178
156PRKACA0.24646151
157EPHB20.24130836
158STK110.22665205
159PRKD10.20820883
160KIT0.20207925
161MARK20.19676737
162PRKCQ0.19522154
163DAPK30.19456630
164MAPK100.19405022
165CSNK1E0.18680222
166BCR0.18241722

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.84292333
2Phototransduction_Homo sapiens_hsa047443.30097306
3Protein export_Homo sapiens_hsa030602.85296899
4Leishmaniasis_Homo sapiens_hsa051402.27792654
5Sphingolipid metabolism_Homo sapiens_hsa006002.24639147
6Antigen processing and presentation_Homo sapiens_hsa046122.24196435
7Type I diabetes mellitus_Homo sapiens_hsa049402.22727098
8Ether lipid metabolism_Homo sapiens_hsa005652.19636223
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13283894
10Staphylococcus aureus infection_Homo sapiens_hsa051502.12421912
11Oxidative phosphorylation_Homo sapiens_hsa001902.08564508
12Homologous recombination_Homo sapiens_hsa034402.03798292
13Proteasome_Homo sapiens_hsa030502.00803013
14RNA polymerase_Homo sapiens_hsa030201.91749410
15* Fanconi anemia pathway_Homo sapiens_hsa034601.85878987
16Nicotine addiction_Homo sapiens_hsa050331.85817268
17Osteoclast differentiation_Homo sapiens_hsa043801.85469955
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84058509
19Fatty acid elongation_Homo sapiens_hsa000621.83419740
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79200875
21Arachidonic acid metabolism_Homo sapiens_hsa005901.73889084
22Sulfur metabolism_Homo sapiens_hsa009201.71431141
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.65684936
24Long-term depression_Homo sapiens_hsa047301.63354954
25Herpes simplex infection_Homo sapiens_hsa051681.60056160
26Tuberculosis_Homo sapiens_hsa051521.58700727
27Other glycan degradation_Homo sapiens_hsa005111.56713924
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53216818
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52001539
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50875261
31Linoleic acid metabolism_Homo sapiens_hsa005911.50736221
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50691283
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.49959728
34Viral myocarditis_Homo sapiens_hsa054161.49847446
35Legionellosis_Homo sapiens_hsa051341.49290495
36Fructose and mannose metabolism_Homo sapiens_hsa000511.44502814
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43963787
38Axon guidance_Homo sapiens_hsa043601.39905056
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39663379
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38122366
41Basal transcription factors_Homo sapiens_hsa030221.35008404
42Spliceosome_Homo sapiens_hsa030401.34043749
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30729764
44Parkinsons disease_Homo sapiens_hsa050121.30511547
45Pertussis_Homo sapiens_hsa051331.27199473
46Serotonergic synapse_Homo sapiens_hsa047261.26969541
47B cell receptor signaling pathway_Homo sapiens_hsa046621.26505274
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23950673
49Non-homologous end-joining_Homo sapiens_hsa034501.18552877
50Measles_Homo sapiens_hsa051621.17966466
51Alzheimers disease_Homo sapiens_hsa050101.17223713
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15579465
53Influenza A_Homo sapiens_hsa051641.15412475
54Taste transduction_Homo sapiens_hsa047421.14881876
55Shigellosis_Homo sapiens_hsa051311.14089129
56Base excision repair_Homo sapiens_hsa034101.13504919
57T cell receptor signaling pathway_Homo sapiens_hsa046601.11738951
58TNF signaling pathway_Homo sapiens_hsa046681.11389495
59Galactose metabolism_Homo sapiens_hsa000521.10110213
60Lysosome_Homo sapiens_hsa041421.10044880
61Autoimmune thyroid disease_Homo sapiens_hsa053201.09100534
62Toxoplasmosis_Homo sapiens_hsa051451.08098513
63Huntingtons disease_Homo sapiens_hsa050161.07831481
64DNA replication_Homo sapiens_hsa030301.07258731
65Glutamatergic synapse_Homo sapiens_hsa047241.05704399
66Morphine addiction_Homo sapiens_hsa050320.99948567
67Salmonella infection_Homo sapiens_hsa051320.99084970
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.98697520
69Pyrimidine metabolism_Homo sapiens_hsa002400.98412644
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97698077
71Graft-versus-host disease_Homo sapiens_hsa053320.97355854
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.96173078
73Fat digestion and absorption_Homo sapiens_hsa049750.96129189
74Epstein-Barr virus infection_Homo sapiens_hsa051690.94968144
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94959214
76Apoptosis_Homo sapiens_hsa042100.94784390
77Phagosome_Homo sapiens_hsa041450.94079315
78Histidine metabolism_Homo sapiens_hsa003400.94016210
79Asthma_Homo sapiens_hsa053100.93926885
80Vitamin digestion and absorption_Homo sapiens_hsa049770.90602423
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.88791370
82Purine metabolism_Homo sapiens_hsa002300.88776938
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87572833
84Mismatch repair_Homo sapiens_hsa034300.87322235
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86225144
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85128502
87Renin-angiotensin system_Homo sapiens_hsa046140.83584071
88Calcium signaling pathway_Homo sapiens_hsa040200.82662351
89Acute myeloid leukemia_Homo sapiens_hsa052210.81994204
90Retinol metabolism_Homo sapiens_hsa008300.81863470
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80723833
92Melanogenesis_Homo sapiens_hsa049160.80434376
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77970375
94Nucleotide excision repair_Homo sapiens_hsa034200.77590939
95Steroid biosynthesis_Homo sapiens_hsa001000.76939706
96Peroxisome_Homo sapiens_hsa041460.76327021
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76229470
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75915463
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75850556
100Wnt signaling pathway_Homo sapiens_hsa043100.74612917
101Basal cell carcinoma_Homo sapiens_hsa052170.74590594
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74383682
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74204356
104Cardiac muscle contraction_Homo sapiens_hsa042600.73105971
105Pentose phosphate pathway_Homo sapiens_hsa000300.72238300
106Ras signaling pathway_Homo sapiens_hsa040140.71365008
107Hepatitis C_Homo sapiens_hsa051600.71174309
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.69881535
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.69601285
110Hepatitis B_Homo sapiens_hsa051610.68580958
111Allograft rejection_Homo sapiens_hsa053300.68388462
112Sulfur relay system_Homo sapiens_hsa041220.67999789
113Chemokine signaling pathway_Homo sapiens_hsa040620.64835980
114Mineral absorption_Homo sapiens_hsa049780.64037155
115Malaria_Homo sapiens_hsa051440.63287562
116Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62101656
117African trypanosomiasis_Homo sapiens_hsa051430.61818842
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.60122296
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59750480
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58195930
121Hematopoietic cell lineage_Homo sapiens_hsa046400.58115302
122Collecting duct acid secretion_Homo sapiens_hsa049660.57791673
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55688798
124Hedgehog signaling pathway_Homo sapiens_hsa043400.55243350
125Rheumatoid arthritis_Homo sapiens_hsa053230.55167762
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54635628
127GABAergic synapse_Homo sapiens_hsa047270.52897369
128ABC transporters_Homo sapiens_hsa020100.51721097
129Primary immunodeficiency_Homo sapiens_hsa053400.49500409
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48652505
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.48178553
132Chemical carcinogenesis_Homo sapiens_hsa052040.47230583
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46744971
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44834981
135Ovarian steroidogenesis_Homo sapiens_hsa049130.44309977
136Cocaine addiction_Homo sapiens_hsa050300.44237927
137Salivary secretion_Homo sapiens_hsa049700.44204146
138Melanoma_Homo sapiens_hsa052180.42223117
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42123583
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41011503
141Carbon metabolism_Homo sapiens_hsa012000.40749832
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39035469
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.37984571
144Folate biosynthesis_Homo sapiens_hsa007900.37910206
145Systemic lupus erythematosus_Homo sapiens_hsa053220.37790577
146MAPK signaling pathway_Homo sapiens_hsa040100.37430486
147HTLV-I infection_Homo sapiens_hsa051660.36361145
148Arginine and proline metabolism_Homo sapiens_hsa003300.35940393
149Metabolic pathways_Homo sapiens_hsa011000.35152655
150RNA degradation_Homo sapiens_hsa030180.34917985
151Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33397456
152Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33243892
153Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32379435
154Prostate cancer_Homo sapiens_hsa052150.31916936
155Alcoholism_Homo sapiens_hsa050340.30964356
156Caffeine metabolism_Homo sapiens_hsa002320.30742245
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30105638
158Vitamin B6 metabolism_Homo sapiens_hsa007500.28918659
159Leukocyte transendothelial migration_Homo sapiens_hsa046700.28617529
160Glutathione metabolism_Homo sapiens_hsa004800.28558769
161Endocytosis_Homo sapiens_hsa041440.27455709
162Adipocytokine signaling pathway_Homo sapiens_hsa049200.26888282
163ErbB signaling pathway_Homo sapiens_hsa040120.26258396
164Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25596848

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