SLURP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)9.40628391
2keratinocyte proliferation (GO:0043616)9.16826975
3epidermis development (GO:0008544)8.57939817
4molting cycle (GO:0042303)8.21348600
5hair cycle (GO:0042633)8.21348600
6positive regulation of potassium ion transmembrane transport (GO:1901381)7.82245236
7water homeostasis (GO:0030104)7.81245536
8lipopolysaccharide metabolic process (GO:0008653)6.49354166
9neutrophil activation involved in immune response (GO:0002283)6.48866107
10desmosome organization (GO:0002934)6.10602292
11bundle of His cell to Purkinje myocyte communication (GO:0086069)6.08939868
12cellular response to zinc ion (GO:0071294)5.98843949
13negative regulation of chondrocyte differentiation (GO:0032331)5.88056221
14calcium ion-dependent exocytosis (GO:0017156)5.86546487
15regulation of potassium ion transmembrane transporter activity (GO:1901016)5.84515725
16long-chain fatty acid biosynthetic process (GO:0042759)5.83089079
17positive regulation of potassium ion transport (GO:0043268)5.69986279
18intermediate filament organization (GO:0045109)5.52148426
19detection of bacterium (GO:0016045)5.13448773
20intermediate filament cytoskeleton organization (GO:0045104)5.03310689
21membrane budding (GO:0006900)5.01452017
22regulation of phospholipase A2 activity (GO:0032429)4.95680979
23positive regulation of cation channel activity (GO:2001259)4.88674406
24intermediate filament-based process (GO:0045103)4.87200475
25negative regulation of adenylate cyclase activity (GO:0007194)4.84751344
26phosphatidylserine acyl-chain remodeling (GO:0036150)4.83299130
27positive regulation of vesicle fusion (GO:0031340)4.82624300
28cellular aldehyde metabolic process (GO:0006081)4.82585145
29establishment of viral latency (GO:0019043)4.82569344
30keratinocyte development (GO:0003334)4.81112318
31linoleic acid metabolic process (GO:0043651)4.72492138
32phosphatidylinositol acyl-chain remodeling (GO:0036149)4.70789763
33negative regulation of complement activation (GO:0045916)4.69739491
34response to phenylpropanoid (GO:0080184)4.69256167
35detection of other organism (GO:0098543)4.63473767
36negative regulation of cyclase activity (GO:0031280)4.59059225
37N-acetylglucosamine metabolic process (GO:0006044)4.50866827
38keratinization (GO:0031424)4.49787626
39ectoderm development (GO:0007398)4.49301217
40regulation of integrin-mediated signaling pathway (GO:2001044)4.47406716
41regulation of metalloenzyme activity (GO:0048552)4.46879819
42glutathione derivative metabolic process (GO:1901685)4.42225077
43glutathione derivative biosynthetic process (GO:1901687)4.42225077
44negative regulation of lyase activity (GO:0051350)4.41956228
45negative regulation of cartilage development (GO:0061037)4.39234389
46regulation of potassium ion transmembrane transport (GO:1901379)4.38909815
47establishment of integrated proviral latency (GO:0075713)4.37676320
48negative regulation of interferon-gamma production (GO:0032689)4.32639330
49primary alcohol catabolic process (GO:0034310)4.32171483
50positive regulation of monocyte chemotaxis (GO:0090026)4.32089812
51uronic acid metabolic process (GO:0006063)4.24124289
52glucuronate metabolic process (GO:0019585)4.24124289
53fatty acid elongation (GO:0030497)4.23746801
54mitochondrial calcium ion transport (GO:0006851)4.22853478
55hair cell differentiation (GO:0035315)4.21547273
56aldehyde catabolic process (GO:0046185)4.20012210
57amino sugar catabolic process (GO:0046348)4.19748899
58negative regulation of protein activation cascade (GO:2000258)4.18973126
59positive regulation of cellular amide metabolic process (GO:0034250)4.07860296
60sequestering of metal ion (GO:0051238)4.04062500
61phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.03868496
62epithelium development (GO:0060429)4.00445764
63cellular glucuronidation (GO:0052695)3.97608268
64hair follicle morphogenesis (GO:0031069)3.97247415
65gap junction assembly (GO:0016264)3.96322118
66transepithelial transport (GO:0070633)3.96100718
67establishment of skin barrier (GO:0061436)3.96010357
68phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.91319642
69nucleotide-sugar biosynthetic process (GO:0009226)3.88475804
70regulation of natural killer cell differentiation (GO:0032823)3.86840114
71establishment of planar polarity (GO:0001736)3.83690699
72establishment of tissue polarity (GO:0007164)3.83690699
73positive regulation of epidermal cell differentiation (GO:0045606)3.82724141
74defense response to fungus (GO:0050832)3.81687842
75negative regulation of cAMP biosynthetic process (GO:0030818)3.81535674
76glucosamine-containing compound metabolic process (GO:1901071)3.77260528
77positive regulation of epidermis development (GO:0045684)3.77070405
78cholesterol biosynthetic process (GO:0006695)3.68631584
79regulation of water loss via skin (GO:0033561)3.67521405
80negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)3.65492074
81negative regulation of cAMP metabolic process (GO:0030815)3.62131130
82negative regulation of interleukin-17 production (GO:0032700)3.59715264
83epithelial cell differentiation (GO:0030855)3.58681421
84phosphatidylcholine acyl-chain remodeling (GO:0036151)3.57146513
85mitochondrial calcium ion homeostasis (GO:0051560)3.49850286
86negative regulation of cyclic nucleotide metabolic process (GO:0030800)3.48017112
87defense response to Gram-negative bacterium (GO:0050829)3.44549562
88regulation of transforming growth factor beta1 production (GO:0032908)3.43952637
89regulation of neuron projection regeneration (GO:0070570)3.42545336
90regulation of axon regeneration (GO:0048679)3.42545336
91protein neddylation (GO:0045116)3.37127265
92sterol biosynthetic process (GO:0016126)3.35309613
93glucosamine-containing compound catabolic process (GO:1901072)3.35000054
94negative regulation of acute inflammatory response (GO:0002674)3.33910432
95regulation of monocyte chemotaxis (GO:0090025)3.32519506
96negative regulation of keratinocyte proliferation (GO:0010839)3.29172234
97negative regulation of purine nucleotide biosynthetic process (GO:1900372)3.29121567
98negative regulation of nucleotide biosynthetic process (GO:0030809)3.29121567
99negative regulation of lipase activity (GO:0060192)3.25918959
100ceramide biosynthetic process (GO:0046513)3.22391340
101fibrinolysis (GO:0042730)3.21662174
102nitric oxide biosynthetic process (GO:0006809)3.17476743
103regulation of keratinocyte differentiation (GO:0045616)3.16951031
104eyelid development in camera-type eye (GO:0061029)3.16407057
105hypotonic response (GO:0006971)3.16195033
106protein homotrimerization (GO:0070207)3.14095059
107removal of superoxide radicals (GO:0019430)3.12198323
108cellular response to superoxide (GO:0071451)3.12198323
109cellular response to oxygen radical (GO:0071450)3.12198323
110hydrogen peroxide catabolic process (GO:0042744)3.12124353
111regulation of ruffle assembly (GO:1900027)3.11448442
112positive regulation of ion transmembrane transporter activity (GO:0032414)3.11103172
113surfactant homeostasis (GO:0043129)3.10993119
114positive regulation of interleukin-8 secretion (GO:2000484)3.05757479
115phosphatidylserine metabolic process (GO:0006658)3.01385582
116positive regulation of T cell chemotaxis (GO:0010820)3.00286627
117regulation of T cell chemotaxis (GO:0010819)3.00286627
118positive regulation of keratinocyte differentiation (GO:0045618)2.98159912
119negative regulation of humoral immune response (GO:0002921)2.97768189
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.97502992
121antimicrobial humoral response (GO:0019730)2.96142640
122negative regulation of catenin import into nucleus (GO:0035414)2.94248850
123membrane raft organization (GO:0031579)2.92963621
124glutathione metabolic process (GO:0006749)2.92626541
125skin morphogenesis (GO:0043589)2.89648988
126regulation of epidermis development (GO:0045682)2.87559919
127ethanol metabolic process (GO:0006067)2.85364503
128glyoxylate metabolic process (GO:0046487)2.84229797
129glial cell migration (GO:0008347)2.84111910
130leukocyte degranulation (GO:0043299)2.82718294
131notochord development (GO:0030903)2.80886606
132ethanol oxidation (GO:0006069)2.80239028
133neutrophil activation (GO:0042119)2.79485804
134DNA deamination (GO:0045006)2.79252871
135peptide cross-linking (GO:0018149)2.78665961
136apical protein localization (GO:0045176)2.78458256
137regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.77474802
138regulation of interleukin-8 secretion (GO:2000482)2.77116910
139positive regulation of granulocyte chemotaxis (GO:0071624)2.76318338
140lipoxygenase pathway (GO:0019372)2.75393657
141regulation of epidermal cell differentiation (GO:0045604)2.73995463
142positive regulation of transporter activity (GO:0032411)2.72607633
143type B pancreatic cell proliferation (GO:0044342)2.71964237
144chemical homeostasis within a tissue (GO:0048875)2.71494343
145adhesion of symbiont to host cell (GO:0044650)2.70400301
146virion attachment to host cell (GO:0019062)2.70400301
147cortical actin cytoskeleton organization (GO:0030866)2.67228946
148positive regulation of glomerulus development (GO:0090193)2.65123341
149detection of external biotic stimulus (GO:0098581)2.65109056
150retinol metabolic process (GO:0042572)2.64484459
151UDP-N-acetylglucosamine metabolic process (GO:0006047)2.61189913
152interferon-gamma secretion (GO:0072643)2.61034010
153N-acetylneuraminate metabolic process (GO:0006054)2.59558283
154hemidesmosome assembly (GO:0031581)2.57642282
155chondroitin sulfate biosynthetic process (GO:0030206)2.57495896
156regulation of membrane protein ectodomain proteolysis (GO:0051043)2.56015837
157cullin deneddylation (GO:0010388)2.55715111
158response to UV-B (GO:0010224)2.55536165
159keratan sulfate catabolic process (GO:0042340)2.53796481
160one-carbon compound transport (GO:0019755)2.53770894
161regulated secretory pathway (GO:0045055)2.53421252
162doxorubicin metabolic process (GO:0044598)2.53343329
163daunorubicin metabolic process (GO:0044597)2.53343329
164polyketide metabolic process (GO:0030638)2.53343329
165polyol transport (GO:0015791)2.53113764
166regulation of potassium ion transport (GO:0043266)2.53085445
167polarized epithelial cell differentiation (GO:0030859)2.50726313
168negative regulation of endopeptidase activity (GO:0010951)2.48575122
169molting cycle process (GO:0022404)2.48156137
170hair cycle process (GO:0022405)2.48156137
171negative regulation of peptidase activity (GO:0010466)2.47406197
172response to fungus (GO:0009620)2.46864790
173positive regulation of p38MAPK cascade (GO:1900745)2.46409506
174regulation of cell proliferation involved in kidney development (GO:1901722)2.42912871
175epithelial cell-cell adhesion (GO:0090136)2.40745673
176regulation of T cell migration (GO:2000404)2.38347057
177positive regulation of humoral immune response (GO:0002922)2.38180654
178alditol phosphate metabolic process (GO:0052646)2.38133986
179epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38025177
180positive regulation of cholesterol efflux (GO:0010875)2.37816346
181complement activation, classical pathway (GO:0006958)2.35490059
182regulation of keratinocyte proliferation (GO:0010837)2.34145860
183phospholipid catabolic process (GO:0009395)2.31854846
184ventricular cardiac muscle cell action potential (GO:0086005)2.30273128
185keratinocyte differentiation (GO:0030216)14.9895829
186positive regulation of potassium ion transmembrane transporter activity (GO:1901018)13.6616126
187epidermal cell differentiation (GO:0009913)12.0413108
188acrosome reaction (GO:0007340)10.6452562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human9.65362644
2* RARG_19884340_ChIP-ChIP_MEFs_Mouse6.59435414
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.28313521
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.68158167
5CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.61215557
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.02354482
7TP53_16413492_ChIP-PET_HCT116_Human3.05909222
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.79334706
9ESR1_15608294_ChIP-ChIP_MCF-7_Human2.70578011
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.64499626
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.58623295
12CLOCK_20551151_ChIP-Seq_293T_Human2.41079039
13NRF2_20460467_ChIP-Seq_MEFs_Mouse2.40605099
14NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.40605099
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39403180
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.26786741
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25789945
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.09489634
19TP53_18474530_ChIP-ChIP_U2OS_Human2.06545254
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02963320
21TP63_22573176_ChIP-Seq_HFKS_Human2.01200573
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.00227657
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.95897327
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.95897327
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.91518219
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88699880
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84937203
28GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.80936029
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.80405547
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79436077
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74429669
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.71241211
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.66468387
34CDX2_20551321_ChIP-Seq_CACO-2_Human1.66234178
35TP63_23658742_ChIP-Seq_EP156T_Human1.63493011
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62344156
37CTCF_27219007_Chip-Seq_Bcells_Human1.60693482
38ERG_20517297_ChIP-Seq_VCAP_Human1.58057404
39EGR1_19032775_ChIP-ChIP_M12_Human1.57694121
40CJUN_26792858_Chip-Seq_BT549_Human1.57178807
41SOX2_20726797_ChIP-Seq_SW620_Human1.55167575
42RXR_22108803_ChIP-Seq_LS180_Human1.51414496
43ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.50895281
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49645774
45PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48309908
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.47028666
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45249509
48CTCF_20526341_ChIP-Seq_ESCs_Human1.44935102
49GATA6_21074721_ChIP-Seq_CACO-2_Human1.42777149
50OCT4_18692474_ChIP-Seq_MEFs_Mouse1.41038356
51SOX2_18692474_ChIP-Seq_MEFs_Mouse1.38456162
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32733866
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.31226509
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30142205
55* SMC4_20622854_ChIP-Seq_HELA_Human1.29270588
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27411921
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27408861
58LXR_22158963_ChIP-Seq_LIVER_Mouse1.24462644
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.23759210
60* BCOR_27268052_Chip-Seq_Bcells_Human1.22963947
61ZNF263_19887448_ChIP-Seq_K562_Human1.22957688
62ATF3_27146783_Chip-Seq_COLON_Human1.22257661
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21812348
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21586477
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.21253101
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21044116
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20321376
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20073623
69* E2F1_20622854_ChIP-Seq_HELA_Human1.19715841
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.19556800
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19077571
72NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16639872
73AR_21572438_ChIP-Seq_LNCaP_Human1.16514577
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16462214
75KLF5_25053715_ChIP-Seq_YYC3_Human1.15708680
76CSB_26484114_Chip-Seq_FIBROBLAST_Human1.14898786
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14418262
78BCL6_27268052_Chip-Seq_Bcells_Human1.12206100
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.12148038
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08419939
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07837438
82RACK7_27058665_Chip-Seq_MCF-7_Human1.07151920
83P53_21459846_ChIP-Seq_SAOS-2_Human1.06893412
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.06069867
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.05656227
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05264580
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03904500
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02954161
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02648723
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02042368
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99613615
92* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99311997
93GATA4_25053715_ChIP-Seq_YYC3_Human0.98019684
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96751598
95SA1_27219007_Chip-Seq_Bcells_Human0.96315450
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94276665
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93366753
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93283945
99VDR_22108803_ChIP-Seq_LS180_Human0.92685539
100FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92532733
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91918026
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91169730
103CEBPB_22108803_ChIP-Seq_LS180_Human0.90742594
104P68_20966046_ChIP-Seq_HELA_Human0.88910814
105BCAT_22108803_ChIP-Seq_LS180_Human0.87804001
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87564914
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87147597
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86356899
109* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85321322
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84409327
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82420941
112NANOG_20526341_ChIP-Seq_ESCs_Human0.80217590
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.80145581
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.80145581
115RBPJ_21746931_ChIP-Seq_IB4_Human0.78582724
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78186694
117GATA3_24758297_ChIP-Seq_MCF-7_Human0.78096487
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77698071
119TAF2_19829295_ChIP-Seq_ESCs_Human0.76811972
120CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.76476554
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75998835
122P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.75696676
123* LXR_22292898_ChIP-Seq_THP-1_Human0.75572862
124MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.75091435
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.75051789
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74708559
127VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74607477
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74442986
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74262146
130JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.73749015
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.73312747
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71808407
133GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.71563353
134OCT4_20526341_ChIP-Seq_ESCs_Human0.70899775
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.69721553
136* ELK3_25401928_ChIP-Seq_HUVEC_Human0.69691954
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.69586107
138GATA6_25053715_ChIP-Seq_YYC3_Human0.69413469
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69132084
140RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.68190517
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.67063039
142TCF4_22108803_ChIP-Seq_LS180_Human0.66654131
143SPI1_20517297_ChIP-Seq_HL60_Human0.66560123
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66109184
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.66077096
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66049206
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65757449
148NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.65504403
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62092625
150SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.62027884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.23619522
2MP0004233_abnormal_muscle_weight6.14274612
3MP0001542_abnormal_bone_strength5.94604702
4MP0005451_abnormal_body_composition4.61615365
5MP0002796_impaired_skin_barrier4.40575976
6MP0005275_abnormal_skin_tensile4.13527760
7MP0003186_abnormal_redox_activity2.91241873
8MP0010234_abnormal_vibrissa_follicle2.78367455
9MP0004043_abnormal_pH_regulation2.63295771
10MP0002736_abnormal_nociception_after2.41060165
11MP0000383_abnormal_hair_follicle2.38727231
12MP0005501_abnormal_skin_physiology2.37943314
13MP0002095_abnormal_skin_pigmentation2.32125190
14MP0005409_darkened_coat_color2.13113922
15MP0002896_abnormal_bone_mineralization2.08436681
16MP0000377_abnormal_hair_follicle2.05891966
17MP0001216_abnormal_epidermal_layer2.03751620
18MP0002168_other_aberrant_phenotype1.99558522
19MP0002282_abnormal_trachea_morphology1.93476774
20MP0004947_skin_inflammation1.85202984
21MP0003941_abnormal_skin_development1.83263426
22MP0002733_abnormal_thermal_nociception1.78530011
23MP0005377_hearing/vestibular/ear_phenot1.69868804
24MP0003878_abnormal_ear_physiology1.69868804
25MP0004885_abnormal_endolymph1.69088858
26MP0002060_abnormal_skin_morphology1.65080624
27MP0000566_synostosis1.62512389
28MP0003786_premature_aging1.60729875
29MP0003011_delayed_dark_adaptation1.60439217
30MP0003279_aneurysm1.60314615
31MP0010771_integument_phenotype1.57425452
32MP0001188_hyperpigmentation1.56949503
33MP0009931_abnormal_skin_appearance1.53944679
34MP0001851_eye_inflammation1.53255257
35MP0003191_abnormal_cellular_cholesterol1.52403337
36MP0001968_abnormal_touch/_nociception1.49654595
37MP0003705_abnormal_hypodermis_morpholog1.43477379
38MP0000749_muscle_degeneration1.43465707
39MP0000762_abnormal_tongue_morphology1.43457250
40MP0000465_gastrointestinal_hemorrhage1.37383021
41MP0002876_abnormal_thyroid_physiology1.35799327
42MP0009115_abnormal_fat_cell1.33241327
43MP0008875_abnormal_xenobiotic_pharmacok1.30972905
44MP0000015_abnormal_ear_pigmentation1.26388938
45MP0008004_abnormal_stomach_pH1.24960763
46MP0009379_abnormal_foot_pigmentation1.23961836
47MP0004782_abnormal_surfactant_physiolog1.23932322
48MP0002009_preneoplasia1.23592324
49MP0003724_increased_susceptibility_to1.23375630
50MP0000427_abnormal_hair_cycle1.22873323
51MP0003385_abnormal_body_wall1.20082806
52MP0003329_amyloid_beta_deposits1.18616501
53MP0005174_abnormal_tail_pigmentation1.14992454
54MP0000647_abnormal_sebaceous_gland1.13482056
55MP0009053_abnormal_anal_canal1.11019738
56MP0001970_abnormal_pain_threshold1.10390242
57MP0004272_abnormal_basement_membrane1.09849664
58MP0000343_altered_response_to1.09689254
59MP0003950_abnormal_plasma_membrane1.09255546
60MP0002998_abnormal_bone_remodeling1.08597855
61MP0005395_other_phenotype1.06055888
62MP0000747_muscle_weakness1.05083217
63MP0002295_abnormal_pulmonary_circulatio1.04862394
64MP0001853_heart_inflammation1.04789119
65MP0004264_abnormal_extraembryonic_tissu1.03152864
66MP0003453_abnormal_keratinocyte_physiol1.02267380
67MP0008438_abnormal_cutaneous_collagen1.01782289
68MP0000579_abnormal_nail_morphology1.00895927
69MP0002933_joint_inflammation1.00777291
70MP0002837_dystrophic_cardiac_calcinosis1.00581140
71MP0003075_altered_response_to0.99368294
72MP0002139_abnormal_hepatobiliary_system0.98976034
73MP0005670_abnormal_white_adipose0.96131305
74MP0004484_altered_response_of0.93986072
75MP0002160_abnormal_reproductive_system0.92995175
76MP0003656_abnormal_erythrocyte_physiolo0.91351584
77MP0002098_abnormal_vibrissa_morphology0.88907686
78MP0003566_abnormal_cell_adhesion0.88813431
79MP0005360_urolithiasis0.87941017
80MP0004381_abnormal_hair_follicle0.87691376
81MP0002163_abnormal_gland_morphology0.87229445
82MP0001191_abnormal_skin_condition0.86041267
83MP0000372_irregular_coat_pigmentation0.84805460
84MP0005085_abnormal_gallbladder_physiolo0.80916220
85MP0001346_abnormal_lacrimal_gland0.80900874
86MP0000367_abnormal_coat/_hair0.80213241
87MP0000371_diluted_coat_color0.80164405
88MP0004859_abnormal_synaptic_plasticity0.79898542
89MP0000751_myopathy0.79745111
90MP0009697_abnormal_copulation0.78477644
91MP0010352_gastrointestinal_tract_polyps0.78034907
92MP0004134_abnormal_chest_morphology0.76450832
93MP0000604_amyloidosis0.76428698
94MP0004185_abnormal_adipocyte_glucose0.75995616
95MP0005266_abnormal_metabolism0.74567213
96MP0002234_abnormal_pharynx_morphology0.73924165
97MP0003795_abnormal_bone_structure0.73735786
98MP0010030_abnormal_orbit_morphology0.73691511
99MP0001299_abnormal_eye_distance/0.73473333
100MP0005365_abnormal_bile_salt0.71020339
101MP0001784_abnormal_fluid_regulation0.70782980
102MP0006054_spinal_hemorrhage0.70369758
103MP0005197_abnormal_uvea_morphology0.69940751
104MP0005248_abnormal_Harderian_gland0.69510004
105MP0005083_abnormal_biliary_tract0.69143056
106MP0003300_gastrointestinal_ulcer0.64742163
107MP0000163_abnormal_cartilage_morphology0.64098493
108MP0002177_abnormal_outer_ear0.63353842
109MP0005165_increased_susceptibility_to0.62755944
110MP0003315_abnormal_perineum_morphology0.62322137
111MP0001177_atelectasis0.61985917
112MP0005023_abnormal_wound_healing0.61802939
113MP0000467_abnormal_esophagus_morphology0.60535262
114MP0001849_ear_inflammation0.59637809
115MP0005171_absent_coat_pigmentation0.58974350
116MP0003638_abnormal_response/metabolism_0.57197256
117MP0005075_abnormal_melanosome_morpholog0.57034377
118MP0001243_abnormal_dermal_layer0.55963512
119MP0001186_pigmentation_phenotype0.55791025
120MP0002113_abnormal_skeleton_development0.54788311
121MP0005623_abnormal_meninges_morphology0.54735633
122MP0005503_abnormal_tendon_morphology0.54656727
123MP0002877_abnormal_melanocyte_morpholog0.53952401
124MP0005330_cardiomyopathy0.53624154
125MP0004883_abnormal_blood_vessel0.52766426
126MP0003091_abnormal_cell_migration0.52330019
127MP0002233_abnormal_nose_morphology0.52090917
128MP0002075_abnormal_coat/hair_pigmentati0.51414266
129MP0010678_abnormal_skin_adnexa0.51275011
130MP0002254_reproductive_system_inflammat0.50905315
131MP0001958_emphysema0.50664583
132MP0005379_endocrine/exocrine_gland_phen0.49254037
133MP0001340_abnormal_eyelid_morphology0.38923016
134MP0000470_abnormal_stomach_morphology0.38756655
135MP0003763_abnormal_thymus_physiology0.31581038
136MP0008789_abnormal_olfactory_epithelium0.30660373
137MP0002111_abnormal_tail_morphology0.30090292
138MP0009780_abnormal_chondrocyte_physiolo0.29383936
139MP0009333_abnormal_splenocyte_physiolog0.27279996
140MP0005193_abnormal_anterior_eye0.26829150
141MP0005666_abnormal_adipose_tissue0.26785949
142MP0000685_abnormal_immune_system0.26622541
143MP0003755_abnormal_palate_morphology0.22549920
144MP0001765_abnormal_ion_homeostasis0.22489244
145MP0005499_abnormal_olfactory_system0.22095063
146MP0005394_taste/olfaction_phenotype0.22095063
147MP0002133_abnormal_respiratory_system0.21729088
148MP0005388_respiratory_system_phenotype0.21729088
149MP0000627_abnormal_mammary_gland0.17928628
150MP0008569_lethality_at_weaning0.16613077
151MP0005375_adipose_tissue_phenotype0.16203263
152MP0002249_abnormal_larynx_morphology0.16179468
153MP0005257_abnormal_intraocular_pressure0.13172804
154MP0003828_pulmonary_edema0.11667573
155MP0000462_abnormal_digestive_system0.11164779
156MP0005508_abnormal_skeleton_morphology0.10373880
157MP0002006_tumorigenesis0.09704982
158MP0002166_altered_tumor_susceptibility0.09167302
159MP0004019_abnormal_vitamin_homeostasis0.08537614
160MP0001984_abnormal_olfaction0.07563756
161MP0002136_abnormal_kidney_physiology0.07425060
162MP0001485_abnormal_pinna_reflex0.06456411
163MP0001756_abnormal_urination0.06372108

Predicted human phenotypes

RankGene SetZ-score
1* Palmoplantar hyperkeratosis (HP:0000972)7.77525836
2* Palmar hyperkeratosis (HP:0010765)7.35804293
3Alopecia of scalp (HP:0002293)6.13380053
4Thick nail (HP:0001805)5.89324854
5Corneal erosion (HP:0200020)5.29557048
6Abnormality of secondary sexual hair (HP:0009888)4.82650374
7Abnormality of the axillary hair (HP:0100134)4.82650374
8Congenital ichthyosiform erythroderma (HP:0007431)4.39346362
9* Palmoplantar keratoderma (HP:0000982)4.21280384
10Follicular hyperkeratosis (HP:0007502)4.16564786
11Ectropion (HP:0000656)4.07187624
12Hypohidrosis (HP:0000966)4.06587705
13Nail dystrophy (HP:0008404)3.90832860
14Conjunctival hamartoma (HP:0100780)3.86599520
15Lip pit (HP:0100267)3.80128493
16Sparse scalp hair (HP:0002209)3.65785664
17Malnutrition (HP:0004395)3.58329817
18Multiple enchondromatosis (HP:0005701)3.53999024
19Right ventricular cardiomyopathy (HP:0011663)3.49377989
20Abnormal blistering of the skin (HP:0008066)3.46560680
21Increased IgE level (HP:0003212)3.43128631
22Pustule (HP:0200039)3.34255119
23Absent eyelashes (HP:0000561)3.29418427
24Abnormal tarsal ossification (HP:0008369)3.29057763
25Abnormality of the salivary glands (HP:0010286)3.21770183
26Abnormal cartilage morphology (HP:0002763)3.15492026
27Protrusio acetabuli (HP:0003179)3.15248773
28Frequent falls (HP:0002359)3.01039160
29Vertebral compression fractures (HP:0002953)3.00630212
30Eczematoid dermatitis (HP:0000976)3.00306176
31Beaking of vertebral bodies (HP:0004568)2.89496924
32Intrahepatic cholestasis (HP:0001406)2.88795505
33Parakeratosis (HP:0001036)2.85520921
34Absent hair (HP:0002298)2.84630747
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.83941577
36Sparse eyelashes (HP:0000653)2.83804660
37Epiphyseal dysplasia (HP:0002656)2.82442167
38Brittle hair (HP:0002299)2.81206236
39Pruritus (HP:0000989)2.80705408
40Autoimmune hemolytic anemia (HP:0001890)2.80564838
41Achilles tendon contracture (HP:0001771)2.72762197
42Abnormality of the Achilles tendon (HP:0005109)2.70918371
43Pheochromocytoma (HP:0002666)2.68768072
44Abnormality of small intestinal villus morphology (HP:0011472)2.65918644
45Villous atrophy (HP:0011473)2.65918644
46Hypergammaglobulinemia (HP:0010702)2.64918981
47Premature rupture of membranes (HP:0001788)2.55089176
48Onycholysis (HP:0001806)2.54685086
49Abnormality of the common coagulation pathway (HP:0010990)2.54342817
50Dehydration (HP:0001944)2.53235322
51Furrowed tongue (HP:0000221)2.51344639
52Vertebral hypoplasia (HP:0008417)2.49953658
53Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.49953658
54Cupped ribs (HP:0000887)2.47358574
55Palpitations (HP:0001962)2.47096960
56Hypotrichosis (HP:0001006)2.46640792
57Poor head control (HP:0002421)2.42919165
58* Erythema (HP:0010783)2.42545785
59Ridged nail (HP:0001807)2.41878047
60Ankle contracture (HP:0006466)2.41799935
61Pili torti (HP:0003777)2.38953323
62Spinal rigidity (HP:0003306)2.38371101
63Urticaria (HP:0001025)2.38073869
64Hoarse voice (HP:0001609)2.36641159
65Erythroderma (HP:0001019)2.35186011
66Abnormality of placental membranes (HP:0011409)2.34099382
67Amniotic constriction ring (HP:0009775)2.34099382
68Irregular epiphyses (HP:0010582)2.33492026
69Abnormality of nail color (HP:0100643)2.32825280
70Neuroendocrine neoplasm (HP:0100634)2.32006370
71Spinal muscular atrophy (HP:0007269)2.31348974
72Abnormal foot bone ossification (HP:0010675)2.30845268
73Abnormality of the intrinsic pathway (HP:0010989)2.29115232
74Foot dorsiflexor weakness (HP:0009027)2.29077771
75Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.26668416
76Cerebral hemorrhage (HP:0001342)2.26494438
77Abnormality of the lumbar spine (HP:0100712)2.25600915
78Woolly hair (HP:0002224)2.25255163
79Slender build (HP:0001533)2.24983232
80Blepharitis (HP:0000498)2.24755130
81Milia (HP:0001056)2.23455412
82Myokymia (HP:0002411)2.23405881
83Barrel-shaped chest (HP:0001552)2.22964650
84Fragile skin (HP:0001030)2.22486589
85Lower limb amyotrophy (HP:0007210)2.20906921
86Abnormal hair laboratory examination (HP:0003328)2.20696113
87Neoplasm of the adrenal gland (HP:0100631)2.19904639
88Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.18158302
89Scapular winging (HP:0003691)2.16188434
90* Fragile nails (HP:0001808)2.14393273
91Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13466570
92Steatorrhea (HP:0002570)2.09725795
93Distal lower limb amyotrophy (HP:0008944)2.06635120
94Abnormality of the foot musculature (HP:0001436)2.05389725
95Nonimmune hydrops fetalis (HP:0001790)2.04992359
96Cavernous hemangioma (HP:0001048)2.04340211
97Natal tooth (HP:0000695)2.04271931
98Laryngomalacia (HP:0001601)2.03628904
99Cervical subluxation (HP:0003308)2.00954759
100Oral leukoplakia (HP:0002745)10.5735695
101Melanocytic nevus (HP:0000995)1.99519882
102Abnormality of carpal bone ossification (HP:0006257)1.97843712
103* Hyperhidrosis (HP:0000975)1.97762840
104* Plantar hyperkeratosis (HP:0007556)1.95957200
105Myelomeningocele (HP:0002475)1.95673209
106Platyspondyly (HP:0000926)1.94898870
107Skin nodule (HP:0200036)1.92194235
108Adenoma sebaceum (HP:0009720)1.90511886
109Angiofibromas (HP:0010615)1.90511886
110Corneal dystrophy (HP:0001131)1.90395646
111Dry skin (HP:0000958)1.90351111
112Deep venous thrombosis (HP:0002625)1.89806613
113Gangrene (HP:0100758)1.89706429
114Increased serum ferritin (HP:0003281)1.89330216
115Distal lower limb muscle weakness (HP:0009053)1.89206285
116Increased variability in muscle fiber diameter (HP:0003557)1.89099110
117Lack of skin elasticity (HP:0100679)1.89047607
118Hamartoma of the eye (HP:0010568)1.87683275
119Advanced eruption of teeth (HP:0006288)1.87371301
120Torticollis (HP:0000473)1.86824191
121Ventricular tachycardia (HP:0004756)1.86668769
122Neonatal short-limb short stature (HP:0008921)1.86050088
123Fat malabsorption (HP:0002630)1.85036189
124Back pain (HP:0003418)1.84114875
125Hypoplastic labia majora (HP:0000059)1.83292907
126Autoamputation (HP:0001218)1.83172741
127Multifactorial inheritance (HP:0001426)1.82126908
128Coxa vara (HP:0002812)1.81202007
129Hyporeflexia of lower limbs (HP:0002600)1.81061760
130Atrophic scars (HP:0001075)1.80228702
131Myotonia (HP:0002486)1.78654028
132Anonychia (HP:0001798)1.78548273
133Vitreoretinal degeneration (HP:0000655)1.77866035
134Sepsis (HP:0100806)1.77256920
135Systemic lupus erythematosus (HP:0002725)1.76474658
136Wormian bones (HP:0002645)1.76382836
137Popliteal pterygium (HP:0009756)1.76303753
138Prolonged partial thromboplastin time (HP:0003645)1.74983563
139Type 1 muscle fiber predominance (HP:0003803)1.74674582
140Acanthosis nigricans (HP:0000956)1.73871249
141Papilloma (HP:0012740)1.73170502
142Verrucae (HP:0200043)1.73170502
143Degeneration of anterior horn cells (HP:0002398)1.72853478
144Abnormality of the anterior horn cell (HP:0006802)1.72853478
145Asymmetric growth (HP:0100555)1.72680835
146Recurrent corneal erosions (HP:0000495)1.72575832
147Neoplasm of head and neck (HP:0012288)1.72493340
148Esophageal neoplasm (HP:0100751)1.72493340
149Soft skin (HP:0000977)1.72192275
150Abnormality of the frontal sinuses (HP:0002687)1.72084886
151Muscle fiber splitting (HP:0003555)1.71421363
152Neoplasm of the heart (HP:0100544)1.71236785
153Abnormality of the labia majora (HP:0012881)1.68402398
154Fine hair (HP:0002213)1.59658507
155Fatigable weakness (HP:0003473)1.58619097
156Abnormality of the neuromuscular junction (HP:0003398)1.58619097
157Curly hair (HP:0002212)1.56797478
158Abnormality of hair growth rate (HP:0011363)1.56036390
159Slow-growing hair (HP:0002217)1.56036390
160* Skin ulcer (HP:0200042)1.53574364
161Conical tooth (HP:0000698)1.52705743
162Carious teeth (HP:0000670)1.49783227
163Seborrheic dermatitis (HP:0001051)1.48690445
164Abnormality of the fingernails (HP:0001231)1.47385863
165Hamartoma (HP:0010566)1.41952515
166Nasolacrimal duct obstruction (HP:0000579)1.39069377
167Xerostomia (HP:0000217)1.37124761
168Selective tooth agenesis (HP:0001592)1.36237079
169Keratoconjunctivitis sicca (HP:0001097)1.31300670
170Abnormality of the dental root (HP:0006486)1.31147940
171Taurodontia (HP:0000679)1.31147940
172Abnormality of permanent molar morphology (HP:0011071)1.31147940
173Neonatal death (HP:0003811)1.27640416
174Split foot (HP:0001839)1.25801086
175Oligodontia (HP:0000677)1.24982860
176Abnormality of molar (HP:0011077)1.23445012
177Abnormality of molar morphology (HP:0011070)1.23445012
178Dry hair (HP:0011359)1.22910855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.09484141
2MST44.11248466
3BCKDK4.07753985
4TAOK13.74473213
5STK243.74332678
6TRPM73.42879152
7ERBB33.37907014
8TGFBR13.29058702
9MAP3K33.24577743
10TESK13.23130366
11LIMK13.14866781
12TESK23.09261659
13PIM22.87117065
14MAP2K32.85375152
15MAP3K112.81756203
16ARAF2.68310477
17MAPKAPK32.60699592
18PBK2.53081633
19TAOK22.45441454
20DAPK22.32120901
21RIPK11.95173946
22FGFR31.92543863
23GRK61.92234508
24SCYL21.82236925
25EPHA31.55604611
26BCR1.49674788
27SGK2231.40755200
28SGK4941.40755200
29PIK3CG1.40424741
30NME21.36722148
31FER1.34270049
32EPHB21.26202431
33MAP2K61.24308742
34MARK21.15555387
35DYRK1B1.14061129
36PRKD21.10573201
37ABL21.09722372
38EEF2K1.09715798
39IRAK11.09405286
40LATS21.09171291
41DDR21.07751767
42CAMKK21.06325160
43TGFBR21.02881918
44PAK41.02220524
45TTN0.97585952
46RPS6KB20.97265334
47ERN10.97103257
48ILK0.96798663
49MAPK70.95353692
50DYRK20.94615777
51MAP3K90.94591339
52KDR0.91576766
53EPHA40.91398191
54MYLK0.90330696
55LATS10.85550660
56PRPF4B0.84266701
57DMPK0.82960592
58PAK30.80993493
59PTK20.80099093
60NME10.79996724
61WNK10.77007097
62IKBKB0.74222036
63PRKCI0.72276947
64BLK0.71097613
65IRAK20.69204751
66TLK10.69058899
67CAMKK10.68871702
68MAP3K120.68592325
69PTK60.68449336
70IKBKE0.67727826
71EPHB10.65461532
72LRRK20.63245283
73MAP3K10.63194844
74NTRK30.60952655
75MAP3K70.60707379
76STK30.59645824
77PLK20.59379414
78EIF2AK10.58097548
79ACVR1B0.55230891
80ALK0.54789941
81TRIB30.53281057
82RAF10.52656634
83MAP2K10.52044645
84CDK140.51884367
85BMX0.51758447
86NEK60.51464981
87GSK3A0.51372608
88TBK10.51361806
89MAP3K50.51219093
90MTOR0.47386938
91ROCK20.47159049
92MAP3K80.46934649
93CAMK2G0.46648544
94JAK30.46608121
95DAPK10.46454692
96FGFR40.46339358
97CDK11A0.45869491
98STK38L0.45785370
99AURKA0.45639997
100CDK60.45637869
101HCK0.45125843
102MET0.44842172
103CDK150.44748397
104IRAK40.44155266
105FGR0.42570067
106PRKCH0.42522777
107CDK180.42265617
108ERBB40.42059217
109STK100.41989728
110MAPK150.41932255
111GRK50.41851974
112EIF2AK30.40886714
113BMPR20.40830164
114MAPK120.39622617
115PKN10.39560372
116SMG10.39452051
117CDK50.39426309
118PRKAA20.38925533
119MINK10.38686930
120PHKG10.36047275
121PHKG20.36047275
122MAPKAPK50.35976534
123ADRBK10.35828202
124EGFR0.35492031
125MST1R0.34761570
126SIK10.34626386
127GRK70.33984491
128SGK30.33865003
129CAMK2D0.33525723
130MAP3K20.33470302
131MAPKAPK20.33432267
132PRKCE0.33372945
133MOS0.33148192
134MAP3K60.33075781
135PRKD10.33031538
136SGK10.32790457
137GRK10.31724897
138PRKCA0.31236854
139SGK20.30688192
140NLK0.30203122
141FGFR10.29959122
142ROCK10.29797978
143PRKCG0.28617054
144RPS6KB10.28242624
145VRK10.27686683
146NTRK10.26917847
147ABL10.26297663
148SRC0.26205736
149KSR20.26193198
150CDC42BPA0.26130971
151CAMK2A0.25695451
152CAMK2B0.25620196
153PDGFRB0.25347594
154ICK0.24879598
155PAK20.24748412
156IRAK30.24226190
157DYRK30.24005738
158RET0.19953695

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.49433109
2Phenylalanine metabolism_Homo sapiens_hsa003606.42991074
3Histidine metabolism_Homo sapiens_hsa003405.21409407
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.99472198
5Linoleic acid metabolism_Homo sapiens_hsa005914.94801985
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.91858270
7Chemical carcinogenesis_Homo sapiens_hsa052044.24976241
8Tyrosine metabolism_Homo sapiens_hsa003503.68308528
9Ether lipid metabolism_Homo sapiens_hsa005653.51367588
10Arachidonic acid metabolism_Homo sapiens_hsa005903.44336632
11beta-Alanine metabolism_Homo sapiens_hsa004103.42659548
12Glutathione metabolism_Homo sapiens_hsa004802.84060998
13Sphingolipid metabolism_Homo sapiens_hsa006002.78417620
14Steroid biosynthesis_Homo sapiens_hsa001002.46102743
15GnRH signaling pathway_Homo sapiens_hsa049122.40328926
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.33542122
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.30658435
18VEGF signaling pathway_Homo sapiens_hsa043702.00257139
19Phototransduction_Homo sapiens_hsa047441.87719518
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81574975
21Sulfur metabolism_Homo sapiens_hsa009201.76640764
22Ovarian steroidogenesis_Homo sapiens_hsa049131.74792809
23Fatty acid elongation_Homo sapiens_hsa000621.64626881
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61665837
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.61239677
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.45627367
27Long-term depression_Homo sapiens_hsa047301.44750248
28Nitrogen metabolism_Homo sapiens_hsa009101.44746783
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42637644
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39568511
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.36803291
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34066091
33Circadian rhythm_Homo sapiens_hsa047101.26038905
34Ras signaling pathway_Homo sapiens_hsa040141.19285118
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18661818
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12275580
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10305737
38Renin-angiotensin system_Homo sapiens_hsa046141.07595818
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04113792
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03452875
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03181592
42Sphingolipid signaling pathway_Homo sapiens_hsa040711.03009970
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02199271
44p53 signaling pathway_Homo sapiens_hsa041151.01513910
45Oxidative phosphorylation_Homo sapiens_hsa001901.00536442
46Choline metabolism in cancer_Homo sapiens_hsa052310.98194818
47Fat digestion and absorption_Homo sapiens_hsa049750.96276432
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91339529
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87306984
50Acute myeloid leukemia_Homo sapiens_hsa052210.87204018
51Alzheimers disease_Homo sapiens_hsa050100.86752700
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.83535872
53Ribosome_Homo sapiens_hsa030100.82458326
54Endocytosis_Homo sapiens_hsa041440.82011123
55Fatty acid degradation_Homo sapiens_hsa000710.77773107
56Dorso-ventral axis formation_Homo sapiens_hsa043200.76774703
57Protein export_Homo sapiens_hsa030600.75569190
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75065500
59Melanogenesis_Homo sapiens_hsa049160.73502147
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72878647
61Glioma_Homo sapiens_hsa052140.71119213
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70274673
63Complement and coagulation cascades_Homo sapiens_hsa046100.68963005
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68915410
65Proteasome_Homo sapiens_hsa030500.68398490
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67526541
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.65619158
68Pancreatic secretion_Homo sapiens_hsa049720.62157248
69Pertussis_Homo sapiens_hsa051330.61483118
70Collecting duct acid secretion_Homo sapiens_hsa049660.59456866
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59005623
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.57490069
73Folate biosynthesis_Homo sapiens_hsa007900.55684346
74Vibrio cholerae infection_Homo sapiens_hsa051100.54618425
75Arginine biosynthesis_Homo sapiens_hsa002200.52914073
76Parkinsons disease_Homo sapiens_hsa050120.52881581
77Propanoate metabolism_Homo sapiens_hsa006400.52804032
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52526527
79Hepatitis C_Homo sapiens_hsa051600.52314724
80Peroxisome_Homo sapiens_hsa041460.51832195
81Inositol phosphate metabolism_Homo sapiens_hsa005620.51801491
82Bladder cancer_Homo sapiens_hsa052190.51626533
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51090508
84ECM-receptor interaction_Homo sapiens_hsa045120.50967327
85Fatty acid metabolism_Homo sapiens_hsa012120.50767925
86Estrogen signaling pathway_Homo sapiens_hsa049150.50415879
87Tuberculosis_Homo sapiens_hsa051520.49881164
88Insulin signaling pathway_Homo sapiens_hsa049100.48489738
89Synaptic vesicle cycle_Homo sapiens_hsa047210.47721896
90Carbon metabolism_Homo sapiens_hsa012000.47635115
91MAPK signaling pathway_Homo sapiens_hsa040100.47249120
92Retinol metabolism_Homo sapiens_hsa008300.46884981
93Amphetamine addiction_Homo sapiens_hsa050310.46088141
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45372918
95Notch signaling pathway_Homo sapiens_hsa043300.44572171
96Toxoplasmosis_Homo sapiens_hsa051450.43552777
97Axon guidance_Homo sapiens_hsa043600.42790406
98Rap1 signaling pathway_Homo sapiens_hsa040150.42645824
99Rheumatoid arthritis_Homo sapiens_hsa053230.42496211
100Influenza A_Homo sapiens_hsa051640.42405935
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41906996
102Huntingtons disease_Homo sapiens_hsa050160.41590171
103Butanoate metabolism_Homo sapiens_hsa006500.40990158
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40495369
105MicroRNAs in cancer_Homo sapiens_hsa052060.40275824
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39707110
107Malaria_Homo sapiens_hsa051440.39669024
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39524856
109PPAR signaling pathway_Homo sapiens_hsa033200.39464278
110Starch and sucrose metabolism_Homo sapiens_hsa005000.39424887
111Glutamatergic synapse_Homo sapiens_hsa047240.39075035
112Calcium signaling pathway_Homo sapiens_hsa040200.37929772
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37825869
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36713173
115Long-term potentiation_Homo sapiens_hsa047200.36567708
116Salmonella infection_Homo sapiens_hsa051320.36384759
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.35583063
118ErbB signaling pathway_Homo sapiens_hsa040120.33984893
119Proteoglycans in cancer_Homo sapiens_hsa052050.32660715
120Dopaminergic synapse_Homo sapiens_hsa047280.32493812
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31518289
122Platelet activation_Homo sapiens_hsa046110.30729436
123Tight junction_Homo sapiens_hsa045300.30255181
124Cardiac muscle contraction_Homo sapiens_hsa042600.29305608
125ABC transporters_Homo sapiens_hsa020100.28161168
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.27178351
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27005769
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26926753
129Circadian entrainment_Homo sapiens_hsa047130.26828654
130Shigellosis_Homo sapiens_hsa051310.25436464
131TGF-beta signaling pathway_Homo sapiens_hsa043500.25358124
132Thyroid hormone synthesis_Homo sapiens_hsa049180.24984791
133GABAergic synapse_Homo sapiens_hsa047270.24953056
134Oxytocin signaling pathway_Homo sapiens_hsa049210.24408668
135Biosynthesis of amino acids_Homo sapiens_hsa012300.23715995
136Dilated cardiomyopathy_Homo sapiens_hsa054140.23319195
137Thyroid cancer_Homo sapiens_hsa052160.22864811
138Pyruvate metabolism_Homo sapiens_hsa006200.22310182
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.22158892
140Bile secretion_Homo sapiens_hsa049760.22005003
141Renal cell carcinoma_Homo sapiens_hsa052110.21969223
142Phagosome_Homo sapiens_hsa041450.21218756
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21202638
144Focal adhesion_Homo sapiens_hsa045100.20115647
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19211352
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.17995295
147Adherens junction_Homo sapiens_hsa045200.17974243
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16989033
149Arginine and proline metabolism_Homo sapiens_hsa003300.16809591
150Staphylococcus aureus infection_Homo sapiens_hsa051500.15345416
151Serotonergic synapse_Homo sapiens_hsa047260.15292909
152Gastric acid secretion_Homo sapiens_hsa049710.15232634
153Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15056240
154Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14777432
155Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13336897
156Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.13197555
157Cocaine addiction_Homo sapiens_hsa050300.12355355
158Salivary secretion_Homo sapiens_hsa049700.11566592
159Cholinergic synapse_Homo sapiens_hsa047250.10813342
160Amoebiasis_Homo sapiens_hsa051460.10098652
161Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.09596559
162Metabolic pathways_Homo sapiens_hsa011000.08864552
163Tryptophan metabolism_Homo sapiens_hsa003800.08640823
164HIF-1 signaling pathway_Homo sapiens_hsa040660.08043443
165Renin secretion_Homo sapiens_hsa049240.07528348

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »