SLU7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.43166538
2central nervous system myelination (GO:0022010)8.43166538
3RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)7.06730055
4tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)7.06730055
5homocysteine metabolic process (GO:0050667)6.01909794
6adenosine metabolic process (GO:0046085)5.60425171
7fatty acid elongation (GO:0030497)5.44497791
8purine nucleotide salvage (GO:0032261)5.33977705
9platelet dense granule organization (GO:0060155)5.13392157
10folic acid-containing compound biosynthetic process (GO:0009396)5.10984539
11microtubule nucleation (GO:0007020)5.08374291
12sulfur amino acid catabolic process (GO:0000098)4.93532122
13regulation of plasminogen activation (GO:0010755)4.82308828
14cysteine metabolic process (GO:0006534)4.82205906
15epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.75200639
16long-chain fatty acid biosynthetic process (GO:0042759)4.65475185
17protein neddylation (GO:0045116)4.58794089
18protein-cofactor linkage (GO:0018065)4.53585049
19pteridine-containing compound biosynthetic process (GO:0042559)4.39605332
20mitochondrial respiratory chain complex I assembly (GO:0032981)4.29565092
21NADH dehydrogenase complex assembly (GO:0010257)4.29565092
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.29565092
23protein complex biogenesis (GO:0070271)4.18189491
24neutrophil activation involved in immune response (GO:0002283)4.09753251
25primary amino compound metabolic process (GO:1901160)3.98085967
26myelination (GO:0042552)3.94412619
27negative regulation of neurotransmitter transport (GO:0051589)3.92454810
28axon ensheathment (GO:0008366)3.92442441
29ensheathment of neurons (GO:0007272)3.92442441
30behavioral response to nicotine (GO:0035095)3.86359539
31inner ear receptor cell development (GO:0060119)3.84881531
32amyloid precursor protein metabolic process (GO:0042982)3.83342986
33negative regulation of DNA biosynthetic process (GO:2000279)3.82093936
34glycosylceramide metabolic process (GO:0006677)3.81104169
35purine-containing compound salvage (GO:0043101)3.79954210
36myelin maintenance (GO:0043217)3.78275959
37response to lipoprotein particle (GO:0055094)3.72481414
38positive regulation of endothelial cell differentiation (GO:0045603)3.72028592
39mitochondrial RNA metabolic process (GO:0000959)3.71948227
40negative regulation of protein localization to cell surface (GO:2000009)3.71097883
41mitochondrial respiratory chain complex assembly (GO:0033108)3.68150819
42cochlea development (GO:0090102)3.64567089
43negative regulation of neurotransmitter secretion (GO:0046929)3.62857541
44acrosome assembly (GO:0001675)3.61099634
45histone H4-K12 acetylation (GO:0043983)3.58117788
46isoprenoid biosynthetic process (GO:0008299)3.56324819
47rRNA methylation (GO:0031167)3.50619583
48white fat cell differentiation (GO:0050872)3.48807380
49phosphatidylglycerol biosynthetic process (GO:0006655)3.43040624
50behavioral fear response (GO:0001662)3.37299512
51behavioral defense response (GO:0002209)3.37299512
52negative regulation of Ras GTPase activity (GO:0034261)3.35483638
53ATP hydrolysis coupled proton transport (GO:0015991)3.26420994
54energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.26420994
55rRNA modification (GO:0000154)3.20077349
56cholesterol biosynthetic process (GO:0006695)3.18348348
57autophagic vacuole fusion (GO:0000046)3.14444857
58protein-chromophore linkage (GO:0018298)3.11149251
59histone H2B ubiquitination (GO:0033523)3.09023477
60indole-containing compound catabolic process (GO:0042436)3.08593907
61indolalkylamine catabolic process (GO:0046218)3.08593907
62tryptophan catabolic process (GO:0006569)3.08593907
63respiratory chain complex IV assembly (GO:0008535)3.07427577
64neurotransmitter uptake (GO:0001504)3.06613205
65negative regulation of execution phase of apoptosis (GO:1900118)3.05717613
66fear response (GO:0042596)3.03303291
67positive regulation of meiosis (GO:0045836)3.00211082
68galactose metabolic process (GO:0006012)3.00006126
69innervation (GO:0060384)2.98622491
70negative regulation of interleukin-1 beta production (GO:0032691)2.96499656
71regulation of gonadotropin secretion (GO:0032276)2.96122865
72intracellular pH reduction (GO:0051452)2.95928446
73galactose catabolic process (GO:0019388)2.93609333
74mast cell activation (GO:0045576)2.92873770
75regulation of vitamin D biosynthetic process (GO:0060556)2.92412100
76GPI anchor biosynthetic process (GO:0006506)2.91537143
77signal peptide processing (GO:0006465)2.91139392
78positive regulation of oligodendrocyte differentiation (GO:0048714)2.89256527
79negative regulation of acute inflammatory response (GO:0002674)2.88678545
80inner mitochondrial membrane organization (GO:0007007)2.88143838
81regulation of sequestering of triglyceride (GO:0010889)2.87887107
82sterol biosynthetic process (GO:0016126)2.86956899
83establishment of mitochondrion localization (GO:0051654)2.85965581
84mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.85446380
85positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.85446380
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.83811856
87tRNA processing (GO:0008033)2.82822681
88positive regulation of meiotic cell cycle (GO:0051446)2.81825061
89ER overload response (GO:0006983)2.81616286
90negative regulation of membrane potential (GO:0045837)2.80916775
91L-amino acid import (GO:0043092)2.80760639
92CENP-A containing nucleosome assembly (GO:0034080)2.80567310
93microtubule polymerization or depolymerization (GO:0031109)2.78696227
94organic cation transport (GO:0015695)2.77274336
95protein K63-linked deubiquitination (GO:0070536)2.76551830
96adaptation of signaling pathway (GO:0023058)2.76183927
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75069175
98regulation of collateral sprouting (GO:0048670)2.74668725
99L-methionine salvage (GO:0071267)2.73712425
100L-methionine biosynthetic process (GO:0071265)2.73712425
101amino acid salvage (GO:0043102)2.73712425
102sulfur amino acid biosynthetic process (GO:0000097)2.73677952
103positive regulation of interleukin-17 production (GO:0032740)2.71535331
104chaperone-mediated protein transport (GO:0072321)2.70501871
105cartilage morphogenesis (GO:0060536)2.69360096
106glycerophospholipid catabolic process (GO:0046475)2.69359289
107piRNA metabolic process (GO:0034587)2.68922285
108single strand break repair (GO:0000012)2.66613419
109amyloid precursor protein catabolic process (GO:0042987)2.66386159
110artery smooth muscle contraction (GO:0014824)2.66040726
111tryptophan metabolic process (GO:0006568)2.66008640
112negative regulation of macroautophagy (GO:0016242)2.65925652
113pH reduction (GO:0045851)2.65822795
114tRNA modification (GO:0006400)2.64504698
115regulation of interleukin-17 production (GO:0032660)2.63680958
116positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.63610532
117regulation of meiosis I (GO:0060631)2.63346874
118endocrine pancreas development (GO:0031018)2.62102900
119cytochrome complex assembly (GO:0017004)2.62013159
120indolalkylamine metabolic process (GO:0006586)2.61953955
121water-soluble vitamin biosynthetic process (GO:0042364)2.61033105
122transferrin transport (GO:0033572)2.60604700
123membrane raft organization (GO:0031579)2.60184225
124cellular iron ion homeostasis (GO:0006879)2.60068026
125indole-containing compound metabolic process (GO:0042430)2.59712142
126protein localization to cilium (GO:0061512)2.59644437
127negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.59404102
128C-terminal protein lipidation (GO:0006501)2.59106017
129leukocyte degranulation (GO:0043299)2.58927792
130sequestering of actin monomers (GO:0042989)2.58815459
131short-chain fatty acid metabolic process (GO:0046459)2.58115542
132substantia nigra development (GO:0021762)2.57252423
1337-methylguanosine RNA capping (GO:0009452)2.56622273
134RNA capping (GO:0036260)2.56622273
135chromatin remodeling at centromere (GO:0031055)2.56324014
136cilium or flagellum-dependent cell motility (GO:0001539)2.55748203
137regulation of endothelial cell differentiation (GO:0045601)2.55127978
138regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.54617987
139termination of RNA polymerase III transcription (GO:0006386)2.53462886
140transcription elongation from RNA polymerase III promoter (GO:0006385)2.53462886
141inositol phosphate catabolic process (GO:0071545)2.53453198
142negative regulation of interleukin-17 production (GO:0032700)2.53373640
143negative regulation of exocytosis (GO:0045920)2.53039306
144cellular response to gamma radiation (GO:0071480)2.52984412
1457-methylguanosine mRNA capping (GO:0006370)2.52763255
146response to redox state (GO:0051775)2.52182124
147DNA methylation involved in gamete generation (GO:0043046)2.52050022
148spermatid nucleus differentiation (GO:0007289)2.51897367
149respiratory burst (GO:0045730)2.51884403
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51080501
151proteasome assembly (GO:0043248)2.51010703
152GPI anchor metabolic process (GO:0006505)2.50953888
153negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.50393223
154positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.49787491
155vesicle fusion (GO:0006906)2.47378987
156neutrophil activation (GO:0042119)2.46664856
157tissue regeneration (GO:0042246)2.46331192
158import into cell (GO:0098657)2.42939850
159dopamine biosynthetic process (GO:0042416)2.40965241
160activated T cell proliferation (GO:0050798)2.40448959
161positive regulation of cell fate commitment (GO:0010455)2.40155190
162regulation of lymphocyte migration (GO:2000401)2.39609220
163positive regulation of alpha-beta T cell proliferation (GO:0046641)2.36686579
164developmental pigmentation (GO:0048066)2.36484331
165regulation of T cell migration (GO:2000404)2.36064419
166negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.35029423
167DNA ligation (GO:0006266)2.34553211
168regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.34179585
169regulated secretory pathway (GO:0045055)2.34013023
170positive regulation of actin filament depolymerization (GO:0030836)2.33332968
171regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.33133535
172granulocyte activation (GO:0036230)2.32893974
173positive regulation of type 2 immune response (GO:0002830)2.31243617
174positive regulation of T cell cytokine production (GO:0002726)2.31062210
175regulation of T-helper 1 type immune response (GO:0002825)2.30729324
176positive regulation of T-helper 1 type immune response (GO:0002827)2.29562282
177glycosphingolipid catabolic process (GO:0046479)2.28800942
178negative regulation of transcription by competitive promoter binding (GO:0010944)2.27014541
179regulation of interleukin-13 production (GO:0032656)2.26809981
180protein K11-linked deubiquitination (GO:0035871)2.26730270
181positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.26040951
182organelle membrane fusion (GO:0090174)2.25160502
183mannosylation (GO:0097502)2.24515615
184oligodendrocyte differentiation (GO:0048709)2.24204659
185preassembly of GPI anchor in ER membrane (GO:0016254)2.21274919
186response to methylmercury (GO:0051597)2.18094406
187regulation of isotype switching to IgG isotypes (GO:0048302)2.17528338
188interleukin-6-mediated signaling pathway (GO:0070102)2.16777262
189cullin deneddylation (GO:0010388)2.15991009
190positive regulation of protein homodimerization activity (GO:0090073)2.12241442
191positive regulation of interleukin-4 production (GO:0032753)2.11755385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.53586492
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.76098055
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26404624
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.21848159
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86571842
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82401474
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.79433929
8ZNF274_21170338_ChIP-Seq_K562_Hela2.79294603
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71455431
10TAF15_26573619_Chip-Seq_HEK293_Human2.64649500
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.61202607
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52873937
13EZH2_22144423_ChIP-Seq_EOC_Human2.50958739
14* GABP_17652178_ChIP-ChIP_JURKAT_Human2.42233762
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.41265476
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.19713862
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19467451
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18800653
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16187784
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15326928
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12267635
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05949060
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05035286
24VDR_22108803_ChIP-Seq_LS180_Human2.02107768
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97731466
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.97703889
27ER_23166858_ChIP-Seq_MCF-7_Human1.95337626
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92859463
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86276452
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83811031
31ELK1_19687146_ChIP-ChIP_HELA_Human1.79961545
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76700510
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74091325
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.72345335
35TP53_22573176_ChIP-Seq_HFKS_Human1.71962902
36* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69300429
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.65178554
38EWS_26573619_Chip-Seq_HEK293_Human1.62709031
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60241018
40IGF1R_20145208_ChIP-Seq_DFB_Human1.57854539
41* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53820177
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53240400
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52649834
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52536145
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51500301
46BCAT_22108803_ChIP-Seq_LS180_Human1.49209430
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48660526
48SUZ12_18555785_Chip-Seq_ESCs_Mouse1.48319542
49VDR_23849224_ChIP-Seq_CD4+_Human1.48280045
50CDX2_22108803_ChIP-Seq_LS180_Human1.46907019
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46578781
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44985464
53CBP_20019798_ChIP-Seq_JUKART_Human1.44985464
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44851888
55CMYC_18555785_Chip-Seq_ESCs_Mouse1.40205827
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.39068407
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.39049804
58GBX2_23144817_ChIP-Seq_PC3_Human1.38462972
59FOXP3_21729870_ChIP-Seq_TREG_Human1.36942295
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.36931207
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35719256
62P300_18555785_Chip-Seq_ESCs_Mouse1.34358084
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.34255285
64STAT3_18555785_Chip-Seq_ESCs_Mouse1.34221708
65AR_25329375_ChIP-Seq_VCAP_Human1.32297578
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30922344
67SMAD4_21799915_ChIP-Seq_A2780_Human1.30559899
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28484588
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26396100
70* STAT3_23295773_ChIP-Seq_U87_Human1.25763654
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25498395
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25247722
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24217410
74NCOR_22424771_ChIP-Seq_293T_Human1.22624163
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22374323
76* SOX2_19829295_ChIP-Seq_ESCs_Human1.21849040
77* NANOG_19829295_ChIP-Seq_ESCs_Human1.21849040
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21294473
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21061677
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.20891828
81SPI1_23547873_ChIP-Seq_NB4_Human1.20458469
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19911785
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19634699
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18679931
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18186651
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17772581
87RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17274352
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16775422
89FUS_26573619_Chip-Seq_HEK293_Human1.16434190
90P53_22387025_ChIP-Seq_ESCs_Mouse1.16222097
91TCF4_22108803_ChIP-Seq_LS180_Human1.16080856
92SOX2_18555785_Chip-Seq_ESCs_Mouse1.16027752
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.15997680
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15997680
95RUNX2_22187159_ChIP-Seq_PCA_Human1.15709381
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.15125146
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14011612
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.13751696
99TCF4_23295773_ChIP-Seq_U87_Human1.13653970
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13464627
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.13399097
102KLF4_18555785_Chip-Seq_ESCs_Mouse1.12075628
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12007966
104SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11524785
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11241345
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10958281
107NMYC_18555785_Chip-Seq_ESCs_Mouse1.10874918
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.10819139
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10641843
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10128398
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.10100534
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09524689
113WT1_19549856_ChIP-ChIP_CCG9911_Human1.08305184
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07394365
115RUNX_20019798_ChIP-Seq_JUKART_Human1.07311865
116P300_19829295_ChIP-Seq_ESCs_Human1.06813383
117ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06694141
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05673981
119GATA1_26923725_Chip-Seq_HPCs_Mouse1.05155258
120OCT4_18555785_Chip-Seq_ESCs_Mouse1.04940528
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04927746
122SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04805447
123GATA3_26560356_Chip-Seq_TH2_Human1.04548398
124RNF2_27304074_Chip-Seq_NSC_Mouse1.04268059
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.03709083
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03318679
127PU1_27457419_Chip-Seq_LIVER_Mouse1.02323289
128REST_21632747_ChIP-Seq_MESCs_Mouse0.99905760
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99877516
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.98372193
131AR_20517297_ChIP-Seq_VCAP_Human0.98324839
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98010544
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96660324
134IRF1_19129219_ChIP-ChIP_H3396_Human0.96139665
135CTCF_18555785_Chip-Seq_ESCs_Mouse0.95865653
136AR_21909140_ChIP-Seq_LNCAP_Human0.95186108
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.94966833
138FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94764460
139OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94465347
140TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94306720
141PRDM14_20953172_ChIP-Seq_ESCs_Human0.94181583
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93660949
143NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93221436
144FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91606947
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91314628
146NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91261695
147LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89910279
148ZFX_18555785_Chip-Seq_ESCs_Mouse0.89502568
149* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89485978
150* SALL4_22934838_ChIP-ChIP_CD34+_Human0.89318463
151MYB_26560356_Chip-Seq_TH2_Human0.89243673
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88955442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland4.46773019
2MP0000920_abnormal_myelination4.13181163
3MP0008995_early_reproductive_senescence3.61894047
4MP0003950_abnormal_plasma_membrane3.54162478
5MP0003136_yellow_coat_color3.17294272
6MP0005171_absent_coat_pigmentation2.93360015
7MP0008260_abnormal_autophagy2.82174874
8MP0001905_abnormal_dopamine_level2.67576093
9MP0001835_abnormal_antigen_presentation2.66516076
10MP0001529_abnormal_vocalization2.66419491
11MP0003880_abnormal_central_pattern2.65824966
12MP0005671_abnormal_response_to2.53903311
13MP0006082_CNS_inflammation2.52552842
14MP0003724_increased_susceptibility_to2.41222703
15MP0004381_abnormal_hair_follicle2.32299092
16MP0009785_altered_susceptibility_to2.31163865
17MP0003690_abnormal_glial_cell2.14406588
18MP0002148_abnormal_hypersensitivity_rea2.11818635
19MP0004147_increased_porphyrin_level2.09940040
20MP0005551_abnormal_eye_electrophysiolog2.08513850
21MP0000569_abnormal_digit_pigmentation2.07059610
22MP0008057_abnormal_DNA_replication2.06432971
23MP0005000_abnormal_immune_tolerance1.99585652
24MP0005360_urolithiasis1.94637365
25MP0002095_abnormal_skin_pigmentation1.93436186
26MP0000013_abnormal_adipose_tissue1.91339089
27MP0002938_white_spotting1.90088220
28MP0002102_abnormal_ear_morphology1.87780113
29MP0006276_abnormal_autonomic_nervous1.86305002
30MP0002419_abnormal_innate_immunity1.83576528
31MP0008872_abnormal_physiological_respon1.80614571
32MP0005409_darkened_coat_color1.79310494
33MP0002723_abnormal_immune_serum1.78330678
34MP0001790_abnormal_immune_system1.77957388
35MP0005387_immune_system_phenotype1.77957388
36MP0003186_abnormal_redox_activity1.77950269
37MP0006072_abnormal_retinal_apoptosis1.77862515
38MP0005670_abnormal_white_adipose1.77222737
39MP0005253_abnormal_eye_physiology1.72394315
40MP0005367_renal/urinary_system_phenotyp1.71855898
41MP0000516_abnormal_urinary_system1.71855898
42MP0000631_abnormal_neuroendocrine_gland1.68763481
43MP0002452_abnormal_antigen_presenting1.68114319
44MP0003806_abnormal_nucleotide_metabolis1.67980113
45MP0005058_abnormal_lysosome_morphology1.66011060
46MP0004742_abnormal_vestibular_system1.64933904
47MP0001800_abnormal_humoral_immune1.63020789
48MP0001188_hyperpigmentation1.60836504
49MP0002420_abnormal_adaptive_immunity1.60539827
50MP0001819_abnormal_immune_cell1.60388844
51MP0001764_abnormal_homeostasis1.55913598
52MP0002837_dystrophic_cardiac_calcinosis1.53835400
53MP0005025_abnormal_response_to1.52676595
54MP0008058_abnormal_DNA_repair1.52505826
55MP0001986_abnormal_taste_sensitivity1.49922561
56MP0009745_abnormal_behavioral_response1.49817019
57MP0003890_abnormal_embryonic-extraembry1.47195219
58MP0003195_calcinosis1.46766079
59MP0002163_abnormal_gland_morphology1.46024068
60MP0000372_irregular_coat_pigmentation1.44959335
61MP0002396_abnormal_hematopoietic_system1.43468643
62MP0003786_premature_aging1.42342856
63MP0005310_abnormal_salivary_gland1.41854048
64MP0008877_abnormal_DNA_methylation1.41644632
65MP0002272_abnormal_nervous_system1.39683541
66MP0005410_abnormal_fertilization1.37293006
67MP0005645_abnormal_hypothalamus_physiol1.35206504
68MP0003634_abnormal_glial_cell1.33618942
69MP0006292_abnormal_olfactory_placode1.33241624
70MP0004270_analgesia1.30949184
71MP0005084_abnormal_gallbladder_morpholo1.28695177
72MP0002876_abnormal_thyroid_physiology1.28303770
73MP0005332_abnormal_amino_acid1.25582751
74MP0003632_abnormal_nervous_system1.24071247
75MP0002735_abnormal_chemical_nociception1.23706278
76MP0004142_abnormal_muscle_tone1.23583658
77MP0009333_abnormal_splenocyte_physiolog1.23265238
78MP0002734_abnormal_mechanical_nocicepti1.19460615
79MP0001944_abnormal_pancreas_morphology1.18121297
80MP0001485_abnormal_pinna_reflex1.16475230
81MP0000647_abnormal_sebaceous_gland1.15277349
82MP0002234_abnormal_pharynx_morphology1.15160692
83MP0000716_abnormal_immune_system1.14910256
84MP0003121_genomic_imprinting1.14466199
85MP0003656_abnormal_erythrocyte_physiolo1.13250960
86MP0008932_abnormal_embryonic_tissue1.12211989
87MP0005408_hypopigmentation1.11046754
88MP0000685_abnormal_immune_system1.10904305
89MP0008789_abnormal_olfactory_epithelium1.10522651
90MP0003329_amyloid_beta_deposits1.09979055
91MP0002229_neurodegeneration1.09909260
92MP0001756_abnormal_urination1.09566403
93MP0002132_abnormal_respiratory_system1.09333040
94MP0009046_muscle_twitch1.07561195
95MP0001324_abnormal_eye_pigmentation1.07263610
96MP0001984_abnormal_olfaction1.07202666
97MP0002064_seizures1.06883043
98MP0003631_nervous_system_phenotype1.03532568
99MP0001851_eye_inflammation1.03012108
100MP0004133_heterotaxia1.02170269
101MP0002160_abnormal_reproductive_system1.01962497
102MP0002398_abnormal_bone_marrow0.99969605
103MP0000026_abnormal_inner_ear0.97784623
104MP0002138_abnormal_hepatobiliary_system0.97049865
105MP0002405_respiratory_system_inflammati0.96985199
106MP0002693_abnormal_pancreas_physiology0.96683251
107MP0002933_joint_inflammation0.96538074
108MP0002069_abnormal_eating/drinking_beha0.96259113
109MP0005389_reproductive_system_phenotype0.94329725
110MP0001919_abnormal_reproductive_system0.94120303
111MP0003763_abnormal_thymus_physiology0.93585156
112MP0002063_abnormal_learning/memory/cond0.92994498
113MP0005423_abnormal_somatic_nervous0.92687656
114MP0000383_abnormal_hair_follicle0.92679952
115MP0008875_abnormal_xenobiotic_pharmacok0.92540055
116MP0000604_amyloidosis0.88835861
117MP0003635_abnormal_synaptic_transmissio0.88139401
118MP0000778_abnormal_nervous_system0.88136551
119MP0002572_abnormal_emotion/affect_behav0.87950007
120MP0003448_altered_tumor_morphology0.87940661
121MP0002210_abnormal_sex_determination0.86905951
122MP0005499_abnormal_olfactory_system0.86620484
123MP0005394_taste/olfaction_phenotype0.86620484
124MP0000015_abnormal_ear_pigmentation0.85017222
125MP0008569_lethality_at_weaning0.84889856
126MP0000653_abnormal_sex_gland0.84081557
127MP0003938_abnormal_ear_development0.83590730
128MP0000689_abnormal_spleen_morphology0.83308986
129MP0005174_abnormal_tail_pigmentation0.83213659
130MP0001502_abnormal_circadian_rhythm0.82974014
131MP0002928_abnormal_bile_duct0.82619495
132MP0002429_abnormal_blood_cell0.82010898
133MP0004043_abnormal_pH_regulation0.80948105
134MP0001533_abnormal_skeleton_physiology0.80164326
135MP0001440_abnormal_grooming_behavior0.80056188
136MP0002736_abnormal_nociception_after0.79898127
137MP0004947_skin_inflammation0.79625899
138MP0002067_abnormal_sensory_capabilities0.78981264
139MP0010678_abnormal_skin_adnexa0.78294145
140MP0001970_abnormal_pain_threshold0.77629061
141MP0001963_abnormal_hearing_physiology0.75948948
142MP0002877_abnormal_melanocyte_morpholog0.75715414
143MP0003866_abnormal_defecation0.75523618
144MP0003718_maternal_effect0.75477605
145MP0000462_abnormal_digestive_system0.75313710
146MP0004924_abnormal_behavior0.75189684
147MP0005386_behavior/neurological_phenoty0.75189684
148MP0002638_abnormal_pupillary_reflex0.74237377
149MP0003633_abnormal_nervous_system0.74052499
150MP0005636_abnormal_mineral_homeostasis0.73903164
151MP0001486_abnormal_startle_reflex0.73367164
152MP0001145_abnormal_male_reproductive0.73177086
153MP0000465_gastrointestinal_hemorrhage0.72528908
154MP0009764_decreased_sensitivity_to0.72207599
155MP0001929_abnormal_gametogenesis0.72058883
156MP0003698_abnormal_male_reproductive0.71368708
157MP0002277_abnormal_respiratory_mucosa0.71037605
158MP0005075_abnormal_melanosome_morpholog0.70569861
159MP0005379_endocrine/exocrine_gland_phen0.69826518
160MP0001968_abnormal_touch/_nociception0.69134527
161MP0002006_tumorigenesis0.68858628
162MP0003183_abnormal_peptide_metabolism0.68815604
163MP0001845_abnormal_inflammatory_respons0.67538055
164MP0001542_abnormal_bone_strength0.67017899
165MP0004510_myositis0.65526706
166MP0001346_abnormal_lacrimal_gland0.65271062
167MP0002722_abnormal_immune_system0.65016973
168MP0003787_abnormal_imprinting0.62461430
169MP0004885_abnormal_endolymph0.62050709

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.44570654
2Abnormality of alanine metabolism (HP:0010916)6.44570654
3Hyperalaninemia (HP:0003348)6.44570654
4Congenital sensorineural hearing impairment (HP:0008527)4.80018324
5Constricted visual fields (HP:0001133)4.71342950
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.60856150
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.60856150
8Cerebral hypomyelination (HP:0006808)4.53907505
9Parakeratosis (HP:0001036)3.93134638
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.68487883
11Abnormal hair whorl (HP:0010721)3.50394152
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.43080906
13White forelock (HP:0002211)3.42818065
14Spontaneous hematomas (HP:0007420)3.39311901
15Decreased electroretinogram (ERG) amplitude (HP:0000654)3.37253283
16Patchy hypopigmentation of hair (HP:0011365)3.35867899
17Peripheral hypomyelination (HP:0007182)3.33352592
18Neurofibrillary tangles (HP:0002185)3.10590110
19Methylmalonic acidemia (HP:0002912)3.01586939
20Homocystinuria (HP:0002156)3.00055424
21Abnormality of homocysteine metabolism (HP:0010919)3.00055424
22Abnormality of macrophages (HP:0004311)2.99740496
23Segmental peripheral demyelination/remyelination (HP:0003481)2.94683178
24Pancreatic cysts (HP:0001737)2.93486000
25Increased neuronal autofluorescent lipopigment (HP:0002074)2.92196498
26Recurrent abscess formation (HP:0002722)2.92038153
27Abnormality of glycolysis (HP:0004366)2.90199620
28Increased serum pyruvate (HP:0003542)2.90199620
29Abnormal auditory evoked potentials (HP:0006958)2.88949360
30Abnormality of serum amino acid levels (HP:0003112)2.87030054
31CNS hypomyelination (HP:0003429)2.84868823
32Stomatitis (HP:0010280)2.84687644
33Attenuation of retinal blood vessels (HP:0007843)2.81739098
34Hepatosplenomegaly (HP:0001433)2.80272481
35Abnormality of the corticospinal tract (HP:0002492)2.78346575
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78277680
37Pancreatic fibrosis (HP:0100732)2.75138392
38Generalized aminoaciduria (HP:0002909)2.73919019
39Chronic hepatic failure (HP:0100626)2.71286666
40Vacuolated lymphocytes (HP:0001922)2.67873466
41Anorexia (HP:0002039)2.66522079
42Recurrent bacterial skin infections (HP:0005406)2.65004162
43True hermaphroditism (HP:0010459)2.61823194
44Retinal dysplasia (HP:0007973)2.61288691
45Leukodystrophy (HP:0002415)2.60895870
46Congenital ichthyosiform erythroderma (HP:0007431)2.60230232
47Chronic obstructive pulmonary disease (HP:0006510)2.59342804
48Obstructive lung disease (HP:0006536)2.59342804
49Molar tooth sign on MRI (HP:0002419)2.58927554
50Abnormality of midbrain morphology (HP:0002418)2.58927554
51Chronic otitis media (HP:0000389)2.55841300
52Spastic paraparesis (HP:0002313)2.55174568
53Hypothermia (HP:0002045)2.55143987
54Prolonged neonatal jaundice (HP:0006579)2.51819675
55Onion bulb formation (HP:0003383)2.50157535
56Eczematoid dermatitis (HP:0000976)2.49064185
57Action tremor (HP:0002345)2.48951877
58Abnormality of T cell number (HP:0011839)2.48149042
59Nephrogenic diabetes insipidus (HP:0009806)2.48145029
60Supernumerary spleens (HP:0009799)2.45120964
61Abnormality of incisor morphology (HP:0011063)2.45098547
62Abnormality of the fetal cardiovascular system (HP:0010948)2.44064572
63Abnormal umbilical cord blood vessels (HP:0011403)2.44064572
64Single umbilical artery (HP:0001195)2.44064572
65Congenital primary aphakia (HP:0007707)2.42506934
66Gait imbalance (HP:0002141)2.42361016
67T lymphocytopenia (HP:0005403)2.41918962
68IgG deficiency (HP:0004315)2.41507198
69Birth length less than 3rd percentile (HP:0003561)2.41168063
70Short tibia (HP:0005736)2.40486597
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40248563
72Mitochondrial inheritance (HP:0001427)2.37146431
73Esophageal varix (HP:0002040)2.32765682
74Increased hepatocellular lipid droplets (HP:0006565)2.32624800
75Increased IgM level (HP:0003496)2.30533751
76Breast hypoplasia (HP:0003187)2.30333142
77Conical tooth (HP:0000698)2.28276954
78Retrobulbar optic neuritis (HP:0100654)2.28251253
79Optic neuritis (HP:0100653)2.28251253
80Cerebral hemorrhage (HP:0001342)2.28174965
81Insulin-resistant diabetes mellitus (HP:0000831)2.27628110
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.26343129
83Autoamputation (HP:0001218)2.24606627
84Increased cerebral lipofuscin (HP:0011813)2.22498189
85Increased CSF lactate (HP:0002490)2.21823362
86Abnormality of the labia minora (HP:0012880)2.21397213
87Abnormality of sulfur amino acid metabolism (HP:0004339)2.20312486
88Acute encephalopathy (HP:0006846)2.17831100
89Dyskinesia (HP:0100660)2.17210509
90Recurrent viral infections (HP:0004429)2.13953211
91Hypomagnesemia (HP:0002917)2.12552776
92Nephronophthisis (HP:0000090)2.12253519
93Thickened helices (HP:0000391)2.12074239
94Hyperglycinemia (HP:0002154)2.11589942
95Sensory axonal neuropathy (HP:0003390)2.09881702
96Lipid accumulation in hepatocytes (HP:0006561)2.09621018
97Agammaglobulinemia (HP:0004432)2.09088293
98Eosinophilia (HP:0001880)2.08927604
99Renal cortical cysts (HP:0000803)2.08202025
100Recurrent skin infections (HP:0001581)2.07442133
101Vaginal atresia (HP:0000148)2.07177067
102Poor speech (HP:0002465)2.07013153
103Medial flaring of the eyebrow (HP:0010747)2.06981151
104Anencephaly (HP:0002323)2.06650922
105Paraparesis (HP:0002385)2.06396770
106Methylmalonic aciduria (HP:0012120)2.05632216
107Conjunctival telangiectasia (HP:0000524)2.05341147
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04529510
109Abnormal mitochondria in muscle tissue (HP:0008316)2.03271355
110Abnormal respiratory motile cilium morphology (HP:0005938)2.02576596
111Abnormal respiratory epithelium morphology (HP:0012253)2.02576596
112Submucous cleft hard palate (HP:0000176)2.02283857
113Limb dystonia (HP:0002451)2.01830216
114Acute necrotizing encephalopathy (HP:0006965)2.01389861
115Abnormality of eosinophils (HP:0001879)2.00837901
116Abnormality of the renal cortex (HP:0011035)1.99775395
117Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98009444
118Absent septum pellucidum (HP:0001331)1.97092325
119Glycosuria (HP:0003076)1.96976318
120Abnormality of urine glucose concentration (HP:0011016)1.96976318
121Tubulointerstitial nephritis (HP:0001970)1.96753590
122Genital tract atresia (HP:0001827)1.96610046
123Metaphyseal dysplasia (HP:0100255)1.95981264
124Median cleft lip (HP:0000161)1.95498730
125Maternal diabetes (HP:0009800)1.95169492
126Supranuclear gaze palsy (HP:0000605)1.94773868
127Lactic acidosis (HP:0003128)1.94528073
128Hyperphosphaturia (HP:0003109)1.94105671
129Pulmonary embolism (HP:0002204)1.92317599
130Esophageal atresia (HP:0002032)1.92150190
131Increased serum lactate (HP:0002151)1.91144010
132Adrenal hypoplasia (HP:0000835)1.90580738
133Panhypogammaglobulinemia (HP:0003139)1.89724411
134Abnormality of the septum pellucidum (HP:0007375)1.89503143
135Abnormality of the vasculature of the conjunctiva (HP:0008054)1.87859970
136Intestinal atresia (HP:0011100)1.87298287
137Encephalitis (HP:0002383)1.87286199
138Recurrent pneumonia (HP:0006532)1.86759369
139Postnatal microcephaly (HP:0005484)1.86552741
140Cerebral inclusion bodies (HP:0100314)1.86312454
141Alacrima (HP:0000522)1.86007267
142Abolished electroretinogram (ERG) (HP:0000550)1.85998413
143Thyroiditis (HP:0100646)1.85559053
144Clumsiness (HP:0002312)1.85212178
145Stenosis of the external auditory canal (HP:0000402)1.84596402
146Oligomenorrhea (HP:0000876)1.82777685
147Absent epiphyses (HP:0010577)1.82626042
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82626042
149Duplicated collecting system (HP:0000081)1.82472745
150Hyperglycemia (HP:0003074)1.81425121
151Abnormal autonomic nervous system physiology (HP:0012332)1.80347779
152Slow saccadic eye movements (HP:0000514)1.79926646
153Axonal loss (HP:0003447)1.78819954
154Petechiae (HP:0000967)1.78729956
155Ketoacidosis (HP:0001993)1.78602183
156Prostate neoplasm (HP:0100787)1.76705124
157Hepatic necrosis (HP:0002605)1.76402136
158Disproportionate short-trunk short stature (HP:0003521)1.76400282
159Hepatocellular necrosis (HP:0001404)1.76243166
160Abnormality of vitamin B metabolism (HP:0004340)1.76181522
161Anhidrosis (HP:0000970)1.75910367
162Chorioretinal atrophy (HP:0000533)1.75882237
163Cerebral edema (HP:0002181)1.75303557
164Abnormality of the renal medulla (HP:0100957)1.75179434
165Morphological abnormality of the inner ear (HP:0011390)1.74200058
166Thick nail (HP:0001805)1.73501810
167Chronic sinusitis (HP:0011109)1.73417940
168Nausea (HP:0002018)1.73260031
169Abnormality of T cells (HP:0002843)1.73145426
170Optic disc pallor (HP:0000543)1.72791912
171Atonic seizures (HP:0010819)1.72524405
172Heterochromia iridis (HP:0001100)1.72145441
173Pendular nystagmus (HP:0012043)1.70305495
174Type II diabetes mellitus (HP:0005978)1.70285913
175Erythroderma (HP:0001019)1.69042219
176Cortical visual impairment (HP:0100704)1.68376687
1773-Methylglutaconic aciduria (HP:0003535)1.68008313
178Progressive macrocephaly (HP:0004481)1.67727708
179Impaired vibration sensation in the lower limbs (HP:0002166)1.67377292
180Hypoplastic pelvis (HP:0008839)1.66165068
181Abnormality of the femoral head (HP:0003368)1.65887660
182Dysautonomia (HP:0002459)1.63851202
183Leukocytosis (HP:0001974)1.63153054
184Severe combined immunodeficiency (HP:0004430)1.62185332
185Ankle clonus (HP:0011448)1.61605687
186Septate vagina (HP:0001153)1.61234176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.99082813
2MST43.58242493
3EIF2AK13.46873972
4FRK3.14394150
5MAPKAPK53.11202586
6BMPR1B2.82718682
7PBK2.72398398
8EPHB12.62516893
9OXSR12.51808053
10TXK2.45532255
11BCR2.38025258
12TESK22.25505403
13AKT32.23811961
14NTRK32.15489356
15MAP4K22.12801380
16WNK32.02364168
17MAP3K31.95596090
18NTRK21.88480717
19BUB11.81463086
20TRIM281.79730135
21MAP2K31.79227768
22MAP3K141.71996188
23MAP3K41.69670968
24PKN11.66705365
25CDK91.66350019
26PNCK1.60226038
27JAK31.57575084
28PINK11.55279471
29TNIK1.52477266
30IRAK41.50550773
31CLK11.49214676
32CAMKK21.44774188
33NUAK11.44629706
34FGFR21.35342883
35SGK4941.34967906
36SGK2231.34967906
37STK161.34257105
38MKNK11.33831093
39WNK41.33214169
40PAK31.33074152
41BRSK21.31490203
42CSNK1G31.28786875
43TSSK61.27897364
44LIMK11.21235878
45ERBB31.19313732
46MAP2K71.13582981
47CASK1.13430890
48INSRR1.12669851
49ADRBK11.11617780
50PIM21.09417367
51EIF2AK31.08998551
52BMPR21.08089327
53PLK21.07061366
54SRPK11.05202065
55IKBKB1.05058788
56MAP4K11.02903012
57WNK11.00866260
58RIPK41.00570092
59MET1.00425381
60DYRK20.99441572
61PHKG20.97253327
62PHKG10.97253327
63TRPM70.97242518
64CSNK1A1L0.93420784
65CSNK1G10.92558466
66GRK70.92272969
67BCKDK0.91905805
68CAMK2B0.90763201
69EPHA30.89415519
70IRAK30.86508730
71ITK0.85849262
72NEK60.85054251
73MELK0.84793613
74TEC0.83447879
75IKBKE0.82557008
76MARK10.81921172
77RPS6KA50.81367509
78ADRBK20.80560409
79PLK30.77522126
80KIT0.77468427
81PLK40.75772725
82SGK30.73771770
83EIF2AK20.73762856
84PRKCQ0.73723579
85ROCK20.73072388
86FGR0.72657604
87STK100.71756795
88CDK190.70537320
89TAOK30.69349005
90NLK0.68506706
91FES0.68176882
92CSNK1G20.68125031
93TLK10.67584166
94MINK10.67357403
95NTRK10.67295672
96LCK0.66211264
97PASK0.65551842
98TIE10.64524214
99CAMK2D0.64463097
100IRAK10.64461393
101MAP2K40.63742154
102BRD40.62137903
103PRKCG0.61985603
104BLK0.61811307
105RPS6KB20.61432411
106VRK10.60846126
107ACVR1B0.59038416
108PRKCE0.58906315
109PIK3CA0.57888524
110WEE10.57412598
111SGK10.57323013
112EPHB20.54754044
113UHMK10.53830570
114GRK10.53655863
115DAPK20.53378275
116CAMK10.53175884
117PRPF4B0.53113622
118BRAF0.52853429
119TNK20.51779681
120MAP3K120.50184523
121LYN0.49780223
122STK30.49477721
123CDK50.47574471
124DYRK30.47511265
125NME10.47299734
126CAMK2G0.47122732
127CDK30.46887343
128MKNK20.46644081
129SYK0.46300524
130DYRK1A0.43845598
131TYK20.42988067
132PRKACA0.42595478
133ZAK0.42007286
134CAMK2A0.41156337
135EGFR0.41032202
136MAPK130.40957997
137PRKCI0.40936679
138MAPKAPK20.40508127
139RPS6KB10.40010190
140MAP2K10.39999699
141SGK20.39483643
142STK40.36811294
143CSF1R0.34047298
144ZAP700.33866137
145MARK30.33430142
146CSK0.32368099
147CSNK1A10.30707531
148TBK10.30431319
149IRAK20.29423794
150CCNB10.27755239
151BTK0.27648024
152MAP3K130.27401710
153GSK3A0.26914668

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.60904956
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.33238648
3Protein export_Homo sapiens_hsa030602.86382885
4Steroid biosynthesis_Homo sapiens_hsa001002.86305667
5Proteasome_Homo sapiens_hsa030502.54175521
6Fatty acid elongation_Homo sapiens_hsa000622.50147007
7Nicotine addiction_Homo sapiens_hsa050332.44094564
8One carbon pool by folate_Homo sapiens_hsa006702.42905909
9RNA polymerase_Homo sapiens_hsa030202.33287983
10Graft-versus-host disease_Homo sapiens_hsa053322.33071457
11Allograft rejection_Homo sapiens_hsa053302.25091042
12Selenocompound metabolism_Homo sapiens_hsa004502.18635317
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12613526
14Primary immunodeficiency_Homo sapiens_hsa053402.09552706
15GABAergic synapse_Homo sapiens_hsa047272.09122159
16Rheumatoid arthritis_Homo sapiens_hsa053232.02703721
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.94228344
18Ether lipid metabolism_Homo sapiens_hsa005651.93501977
19Morphine addiction_Homo sapiens_hsa050321.89504577
20Vitamin B6 metabolism_Homo sapiens_hsa007501.82045110
21Autoimmune thyroid disease_Homo sapiens_hsa053201.65939340
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65542402
23Synaptic vesicle cycle_Homo sapiens_hsa047211.61589969
24Sphingolipid metabolism_Homo sapiens_hsa006001.58111510
25Oxidative phosphorylation_Homo sapiens_hsa001901.56921871
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54869331
27Butanoate metabolism_Homo sapiens_hsa006501.53506651
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53225379
29Non-homologous end-joining_Homo sapiens_hsa034501.49975552
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49340639
31Phagosome_Homo sapiens_hsa041451.48434332
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46717444
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43691098
34Basal transcription factors_Homo sapiens_hsa030221.41187714
35Collecting duct acid secretion_Homo sapiens_hsa049661.40771086
36Antigen processing and presentation_Homo sapiens_hsa046121.37555292
37Nitrogen metabolism_Homo sapiens_hsa009101.36773482
38Propanoate metabolism_Homo sapiens_hsa006401.31105684
39Type I diabetes mellitus_Homo sapiens_hsa049401.29592693
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.29576704
41Leishmaniasis_Homo sapiens_hsa051401.27377167
42Dopaminergic synapse_Homo sapiens_hsa047281.27012247
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.25789004
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24999415
45Arginine biosynthesis_Homo sapiens_hsa002201.23199168
46Malaria_Homo sapiens_hsa051441.22363379
47Peroxisome_Homo sapiens_hsa041461.18303967
48Taste transduction_Homo sapiens_hsa047421.15527997
49Hematopoietic cell lineage_Homo sapiens_hsa046401.15291459
50Circadian entrainment_Homo sapiens_hsa047131.13163766
51Vibrio cholerae infection_Homo sapiens_hsa051101.12199272
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11032170
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10002866
54Glutamatergic synapse_Homo sapiens_hsa047241.09250605
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07445865
56Parkinsons disease_Homo sapiens_hsa050121.05688313
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05593290
58Asthma_Homo sapiens_hsa053101.05528704
59Olfactory transduction_Homo sapiens_hsa047401.05076297
60Epstein-Barr virus infection_Homo sapiens_hsa051691.00449109
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99629204
62Histidine metabolism_Homo sapiens_hsa003400.99477714
63T cell receptor signaling pathway_Homo sapiens_hsa046600.99106266
64Lysosome_Homo sapiens_hsa041420.98987085
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98926360
66Shigellosis_Homo sapiens_hsa051310.96836208
67Salmonella infection_Homo sapiens_hsa051320.95035528
68Alzheimers disease_Homo sapiens_hsa050100.94713419
69Measles_Homo sapiens_hsa051620.94592611
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.94519773
71Sulfur metabolism_Homo sapiens_hsa009200.94002157
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87961844
73Cardiac muscle contraction_Homo sapiens_hsa042600.86238497
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85648551
75Regulation of autophagy_Homo sapiens_hsa041400.84409812
76Phototransduction_Homo sapiens_hsa047440.83812303
77Herpes simplex infection_Homo sapiens_hsa051680.83447703
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82392504
79Homologous recombination_Homo sapiens_hsa034400.81953737
80Pertussis_Homo sapiens_hsa051330.80951660
81African trypanosomiasis_Homo sapiens_hsa051430.80852442
82Tuberculosis_Homo sapiens_hsa051520.80460944
83Cholinergic synapse_Homo sapiens_hsa047250.77271740
84Chemokine signaling pathway_Homo sapiens_hsa040620.77186781
85Mismatch repair_Homo sapiens_hsa034300.77006208
86Huntingtons disease_Homo sapiens_hsa050160.76695709
87Other glycan degradation_Homo sapiens_hsa005110.76185988
88Linoleic acid metabolism_Homo sapiens_hsa005910.75913510
89Osteoclast differentiation_Homo sapiens_hsa043800.74836445
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73745055
91B cell receptor signaling pathway_Homo sapiens_hsa046620.72888717
92* Spliceosome_Homo sapiens_hsa030400.72019095
93Insulin secretion_Homo sapiens_hsa049110.71861056
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71301178
95Circadian rhythm_Homo sapiens_hsa047100.71026088
96Sulfur relay system_Homo sapiens_hsa041220.69770627
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68957287
98Endocytosis_Homo sapiens_hsa041440.67320063
99Serotonergic synapse_Homo sapiens_hsa047260.67205616
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.65742313
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65272554
102Nucleotide excision repair_Homo sapiens_hsa034200.63656642
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.63463346
104Tryptophan metabolism_Homo sapiens_hsa003800.62021931
105Amphetamine addiction_Homo sapiens_hsa050310.60266415
106Folate biosynthesis_Homo sapiens_hsa007900.59420945
107Renal cell carcinoma_Homo sapiens_hsa052110.58273313
108Legionellosis_Homo sapiens_hsa051340.57971455
109Influenza A_Homo sapiens_hsa051640.56540593
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56343000
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55939700
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55092246
113RNA transport_Homo sapiens_hsa030130.53573935
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52435444
115Hepatitis C_Homo sapiens_hsa051600.52053900
116Metabolic pathways_Homo sapiens_hsa011000.52010443
117Ribosome_Homo sapiens_hsa030100.50951446
118Cell cycle_Homo sapiens_hsa041100.50832830
119Caffeine metabolism_Homo sapiens_hsa002320.50205611
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49166086
121Retinol metabolism_Homo sapiens_hsa008300.48622618
122Purine metabolism_Homo sapiens_hsa002300.46180604
123Cocaine addiction_Homo sapiens_hsa050300.45541811
124mRNA surveillance pathway_Homo sapiens_hsa030150.43580158
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42795797
126Arachidonic acid metabolism_Homo sapiens_hsa005900.42728786
127Mineral absorption_Homo sapiens_hsa049780.42137040
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41267908
129Toxoplasmosis_Homo sapiens_hsa051450.39969194
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39659229
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.38745136
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38324770
133Ras signaling pathway_Homo sapiens_hsa040140.37926148
134Viral myocarditis_Homo sapiens_hsa054160.36995684
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36865934
136TNF signaling pathway_Homo sapiens_hsa046680.35035961
137Chemical carcinogenesis_Homo sapiens_hsa052040.34653765
138ABC transporters_Homo sapiens_hsa020100.34181530
139RNA degradation_Homo sapiens_hsa030180.33867666
140Axon guidance_Homo sapiens_hsa043600.33463998
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33394248
142Fanconi anemia pathway_Homo sapiens_hsa034600.32417268
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31414877
144Apoptosis_Homo sapiens_hsa042100.30383705
145Vitamin digestion and absorption_Homo sapiens_hsa049770.29720159
146Hepatitis B_Homo sapiens_hsa051610.29180760
1472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27236374
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26289516
149Base excision repair_Homo sapiens_hsa034100.25786354
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24767988
151Dorso-ventral axis formation_Homo sapiens_hsa043200.21798925

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