SLPI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diterpenoid biosynthetic process (GO:0016102)8.53535223
2axoneme assembly (GO:0035082)8.21719826
3primary alcohol catabolic process (GO:0034310)7.50193580
4left/right pattern formation (GO:0060972)7.39282818
5cellular extravasation (GO:0045123)7.32414216
6ethanol metabolic process (GO:0006067)6.10115849
7left/right axis specification (GO:0070986)5.95622663
8lipoxygenase pathway (GO:0019372)5.92635071
9terpenoid biosynthetic process (GO:0016114)5.85269887
10regulation of cilium movement (GO:0003352)5.67624949
11one-carbon compound transport (GO:0019755)5.67550011
12response to xenobiotic stimulus (GO:0009410)5.49385374
13production of molecular mediator involved in inflammatory response (GO:0002532)5.49026360
14pyrimidine-containing compound transmembrane transport (GO:0072531)5.44947257
15vitamin transmembrane transport (GO:0035461)5.36355098
16respiratory burst (GO:0045730)5.22913238
17response to peptidoglycan (GO:0032494)5.21440915
18ventricular system development (GO:0021591)5.20060651
19mannose metabolic process (GO:0006013)5.17310342
20neutrophil activation involved in immune response (GO:0002283)5.12241374
21regulation of apoptotic cell clearance (GO:2000425)5.10361630
22neutrophil mediated immunity (GO:0002446)5.08971810
23microtubule bundle formation (GO:0001578)5.03652242
24response to fungus (GO:0009620)4.89703545
25ethanol oxidation (GO:0006069)4.84275858
26retinoic acid metabolic process (GO:0042573)4.81416459
27leukocyte migration involved in inflammatory response (GO:0002523)4.80641995
28negative regulation of humoral immune response (GO:0002921)4.62477001
29pentose-phosphate shunt (GO:0006098)4.61400296
30negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.59845163
31regulation of interleukin-5 production (GO:0032674)4.59784060
32positive regulation of tolerance induction (GO:0002645)4.57399975
33leukotriene metabolic process (GO:0006691)4.53266907
34glomerular epithelial cell development (GO:0072310)4.46523081
35lung epithelium development (GO:0060428)4.43365229
36response to muramyl dipeptide (GO:0032495)4.42702469
37intraciliary transport (GO:0042073)4.41519415
38tolerance induction (GO:0002507)4.40526050
39negative regulation of T cell differentiation in thymus (GO:0033085)4.40041523
40negative regulation of interleukin-12 production (GO:0032695)4.39560183
41regulation of interleukin-13 production (GO:0032656)4.38503063
42cilium organization (GO:0044782)4.37700153
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.28356308
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.28356308
45regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.26492108
46NADPH regeneration (GO:0006740)4.23035205
47cilium assembly (GO:0042384)4.22384788
48defense response to fungus (GO:0050832)4.09532783
49establishment of apical/basal cell polarity (GO:0035089)4.08226138
50calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.05009194
51multicellular organismal water homeostasis (GO:0050891)4.02319626
52negative regulation of cell killing (GO:0031342)3.99600978
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.99600978
54regulation of integrin activation (GO:0033623)3.99579551
55negative regulation of B cell mediated immunity (GO:0002713)3.97179422
56negative regulation of immunoglobulin mediated immune response (GO:0002890)3.97179422
57retinol metabolic process (GO:0042572)3.96962196
58detection of molecule of bacterial origin (GO:0032490)3.96940787
59positive regulation by symbiont of host defense response (GO:0052509)3.93815658
60modulation by symbiont of host defense response (GO:0052031)3.93815658
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.93815658
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.93815658
63positive regulation by organism of defense response of other organism involved in symbiotic interact3.93815658
64modulation by symbiont of host immune response (GO:0052553)3.93815658
65hydrogen peroxide biosynthetic process (GO:0050665)3.91696878
66Arp2/3 complex-mediated actin nucleation (GO:0034314)3.90050908
67disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.90029021
68killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.90029021
69antigen processing and presentation of endogenous antigen (GO:0019883)3.87986771
70leukocyte aggregation (GO:0070486)3.86247761
71reactive oxygen species biosynthetic process (GO:1903409)3.84513748
72primary alcohol metabolic process (GO:0034308)3.81879409
73myeloid leukocyte mediated immunity (GO:0002444)3.79764101
74positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.77663031
75desmosome organization (GO:0002934)3.76894505
76regulation of germinal center formation (GO:0002634)3.75333217
77negative regulation of phagocytosis (GO:0050765)3.74893642
78macrophage differentiation (GO:0030225)3.71230844
79surfactant homeostasis (GO:0043129)3.64427892
80protein localization to cilium (GO:0061512)3.62845982
81neutrophil activation (GO:0042119)3.61867334
82regulation of neuron projection regeneration (GO:0070570)3.55134839
83regulation of axon regeneration (GO:0048679)3.55134839
84germinal center formation (GO:0002467)3.54694177
85O-glycan processing (GO:0016266)3.49125389
86leukocyte cell-cell adhesion (GO:0007159)3.48957066
87positive regulation of T cell chemotaxis (GO:0010820)3.47635973
88regulation of T cell chemotaxis (GO:0010819)3.47635973
89superoxide anion generation (GO:0042554)3.47379322
90regulation of B cell receptor signaling pathway (GO:0050855)3.45622856
91progesterone metabolic process (GO:0042448)3.45617167
92granulocyte activation (GO:0036230)3.45147299
93sperm capacitation (GO:0048240)3.44914664
94water homeostasis (GO:0030104)3.44854914
95complement activation, alternative pathway (GO:0006957)3.44665279
96hypotonic response (GO:0006971)3.44333419
97establishment of planar polarity (GO:0001736)3.43721885
98establishment of tissue polarity (GO:0007164)3.43721885
99regulation of phagocytosis (GO:0050764)3.42719917
100positive regulation of antigen processing and presentation (GO:0002579)3.42175229
101glucose 6-phosphate metabolic process (GO:0051156)3.38436415
102regulation of tolerance induction (GO:0002643)3.37512080
103regulation of dendritic cell antigen processing and presentation (GO:0002604)3.37234553
104establishment of monopolar cell polarity (GO:0061162)3.35450424
105establishment or maintenance of monopolar cell polarity (GO:0061339)3.35450424
106detection of external biotic stimulus (GO:0098581)3.35318565
107cellular component assembly involved in morphogenesis (GO:0010927)3.34183795
108regulation of interleukin-6 biosynthetic process (GO:0045408)3.33751743
109microtubule-based movement (GO:0007018)3.33615821
110sequestering of metal ion (GO:0051238)3.33189745
111centriole assembly (GO:0098534)3.32854486
112exogenous drug catabolic process (GO:0042738)3.29874527
113negative regulation of interleukin-6 production (GO:0032715)3.28815929
114cell projection assembly (GO:0030031)3.27698746
115leukotriene biosynthetic process (GO:0019370)3.27122273
116angiogenesis involved in wound healing (GO:0060055)3.25372312
117leukocyte mediated cytotoxicity (GO:0001909)3.24701647
118macrophage activation involved in immune response (GO:0002281)3.23073525
119regulation of mast cell degranulation (GO:0043304)3.20932187
120regulation of mast cell activation (GO:0033003)3.20522075
121opsonization (GO:0008228)3.20492517
122myeloid cell activation involved in immune response (GO:0002275)3.20473071
123lipopolysaccharide-mediated signaling pathway (GO:0031663)3.19987723
124neutrophil chemotaxis (GO:0030593)3.16217339
125phosphate ion transmembrane transport (GO:0035435)3.16212856
126apoptotic cell clearance (GO:0043277)3.11423962
127pinocytosis (GO:0006907)3.11099745
128neutrophil migration (GO:1990266)3.06707011
129negative regulation of inclusion body assembly (GO:0090084)3.05575947
130excretion (GO:0007588)3.04057994
131chemical homeostasis within a tissue (GO:0048875)3.03515600
132regulation of microtubule-based movement (GO:0060632)3.03176917
133keratinocyte proliferation (GO:0043616)3.02953979
134glucose catabolic process (GO:0006007)3.02888265
135cytoplasmic microtubule organization (GO:0031122)3.02409577
136cilium morphogenesis (GO:0060271)3.01283871
137regulation of antigen processing and presentation (GO:0002577)3.00357486
138regulation of macrophage chemotaxis (GO:0010758)3.00108392
139dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.97269765
140complement activation (GO:0006956)2.95404254
141regulation of mast cell activation involved in immune response (GO:0033006)2.94500622
142chronic inflammatory response (GO:0002544)2.92392538
143regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.92185533
144detection of other organism (GO:0098543)2.91136937
145ear development (GO:0043583)2.90357846
146nucleoside diphosphate phosphorylation (GO:0006165)2.89509691
147positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.89373546
148regulation of leukocyte degranulation (GO:0043300)2.88796555
149detection of biotic stimulus (GO:0009595)2.85943485
150regulation of lymphocyte chemotaxis (GO:1901623)2.84534594
151regulation of lymphocyte migration (GO:2000401)2.84373108
152leukocyte degranulation (GO:0043299)2.82990011
153positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.82876020
154iron ion import (GO:0097286)2.82070562
155glutathione derivative biosynthetic process (GO:1901687)2.82037422
156glutathione derivative metabolic process (GO:1901685)2.82037422
157killing of cells of other organism (GO:0031640)2.80589180
158disruption of cells of other organism (GO:0044364)2.80589180
159asymmetric protein localization (GO:0008105)2.79706816
160positive regulation of tumor necrosis factor production (GO:0032760)2.78269465
161response to protozoan (GO:0001562)2.77901237
162positive regulation of B cell differentiation (GO:0045579)2.77187637
163phagocytosis (GO:0006909)2.76777373
164regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76404565
165regulation of macrophage cytokine production (GO:0010935)2.75711393
166retinal metabolic process (GO:0042574)2.75040541
167regulation of T cell migration (GO:2000404)2.72796207
168negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.71024610
169actin nucleation (GO:0045010)2.70647054
170positive regulation of phagocytosis (GO:0050766)2.70201207
171adaptation of signaling pathway (GO:0023058)2.70078594
172apical protein localization (GO:0045176)2.70000289
173negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.68791672
174regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.66881754
175establishment of skin barrier (GO:0061436)2.66466876
176lateral ventricle development (GO:0021670)2.66432231
177oligosaccharide biosynthetic process (GO:0009312)2.66141201
178positive regulation of smoothened signaling pathway (GO:0045880)2.65116273
179regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63225224
180phosphate ion transport (GO:0006817)2.62117605
181drug catabolic process (GO:0042737)2.61066508
182regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.58003537
183sodium ion homeostasis (GO:0055078)2.55871119
184microtubule polymerization or depolymerization (GO:0031109)2.55596274
185cornea development in camera-type eye (GO:0061303)2.53799226
186polyol transport (GO:0015791)2.53131639
187regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.50719963
188regulation of water loss via skin (GO:0033561)2.49611323
189lateral sprouting from an epithelium (GO:0060601)2.48039795
190keratinization (GO:0031424)2.47533094
191axonemal dynein complex assembly (GO:0070286)17.6440353
192cilium or flagellum-dependent cell motility (GO:0001539)14.5310240
193cilium movement (GO:0003341)12.5948189
194motile cilium assembly (GO:0044458)11.7101320
195epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.6931465
196epithelial cilium movement (GO:0003351)10.3583332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.03606421
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.86519632
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.65740244
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.44122456
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.42500853
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.29116621
7* MYB_21317192_ChIP-Seq_ERMYB_Mouse4.22020144
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.87876055
9E2F7_22180533_ChIP-Seq_HELA_Human3.70900338
10VDR_21846776_ChIP-Seq_THP-1_Human3.59368692
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43195176
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.31553163
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.22426514
14IRF8_27001747_Chip-Seq_BMDM_Mouse3.14615298
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05096795
16IRF8_22096565_ChIP-ChIP_GC-B_Human3.02075565
17* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.96135103
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.94625325
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.80419365
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79789164
21SCL_19346495_ChIP-Seq_HPC-7_Human2.79642376
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78654367
23MYC_22102868_ChIP-Seq_BL_Human2.75372115
24VDR_24763502_ChIP-Seq_THP-1_Human2.73609009
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.64007425
26ESR1_20079471_ChIP-ChIP_T-47D_Human2.60403649
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.52126887
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47733896
29SPI1_23547873_ChIP-Seq_NB4_Human2.46521512
30* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26439612
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23258716
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22896985
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21918506
34SOX2_20726797_ChIP-Seq_SW620_Human2.21897435
35RUNX1_22412390_ChIP-Seq_EML_Mouse2.17258685
36SPI1_23127762_ChIP-Seq_K562_Human2.08064738
37STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06553963
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human2.02337842
39* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02070070
40TCF7_22412390_ChIP-Seq_EML_Mouse2.01489020
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.98389029
42CDX2_20551321_ChIP-Seq_CACO-2_Human1.97434242
43MYB_26560356_Chip-Seq_TH2_Human1.95208458
44UTX_26944678_Chip-Seq_JUKART_Human1.94420459
45P63_26484246_Chip-Seq_KERATINOCYTES_Human1.91146323
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.90341600
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87597573
48MAF_26560356_Chip-Seq_TH1_Human1.87542122
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85499674
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.83829422
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83558722
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82699930
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82022100
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80658999
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80458084
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80377573
57FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.77916739
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.75221849
59AHR_22903824_ChIP-Seq_MCF-7_Human1.75196676
60FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.75142709
61DROSHA_22980978_ChIP-Seq_HELA_Human1.74193343
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73279374
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73004168
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72666607
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72547299
66TP63_23658742_ChIP-Seq_EP156T_Human1.70591590
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.63489232
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.63076548
69* KLF5_25053715_ChIP-Seq_YYC3_Human1.62505587
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61253211
71ZNF263_19887448_ChIP-Seq_K562_Human1.59022060
72MYB_26560356_Chip-Seq_TH1_Human1.58705920
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58314756
74STAT1_20625510_ChIP-Seq_HELA_Human1.55690940
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.55138082
76RUNX_20019798_ChIP-Seq_JUKART_Human1.55135039
77GATA4_25053715_ChIP-Seq_YYC3_Human1.54936616
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53404692
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.47260087
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.45048216
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44057164
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44057164
83* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43929522
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42589871
85TP53_18474530_ChIP-ChIP_U2OS_Human1.40514150
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40218509
87PU_27001747_Chip-Seq_BMDM_Mouse1.40105391
88GATA3_24758297_ChIP-Seq_MCF-7_Human1.37858252
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34795265
90SMC4_20622854_ChIP-Seq_HELA_Human1.34366962
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34230640
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34131515
93GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32740402
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31934227
95LXR_22292898_ChIP-Seq_THP-1_Human1.30725836
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30575834
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30039525
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28918779
99CLOCK_20551151_ChIP-Seq_293T_Human1.28435185
100KDM2B_26808549_Chip-Seq_DND41_Human1.28417681
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26975466
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26115360
103LXR_22158963_ChIP-Seq_LIVER_Mouse1.24564485
104MAF_26560356_Chip-Seq_TH2_Human1.23734423
105TP63_22573176_ChIP-Seq_HFKS_Human1.23457686
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22274225
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22155342
108FOXA1_25552417_ChIP-Seq_VCAP_Human1.21108686
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19393980
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18769183
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18339325
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17979295
113GATA3_27048872_Chip-Seq_THYMUS_Human1.17753519
114RXR_22158963_ChIP-Seq_LIVER_Mouse1.15907019
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15475746
116GATA6_25053715_ChIP-Seq_YYC3_Human1.15285008
117SPI1_20517297_ChIP-Seq_HL60_Human1.14847424
118CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14204345
119TP63_17297297_ChIP-ChIP_HaCaT_Human1.13894412
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13650394
121* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13424197
122VDR_24787735_ChIP-Seq_THP-1_Human1.11329589
123GATA2_19941826_ChIP-Seq_K562_Human1.10314160
124RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10151404
125SMAD3_21741376_ChIP-Seq_HESCs_Human1.08915799
126PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08578809
127HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08059531
128GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07672164
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07259145
130ETV1_20927104_ChIP-Seq_GIST48_Human1.06915572
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06751386
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06289156
133HNFA_21074721_ChIP-Seq_CACO-2_Human1.04474681
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04470178
135PHF8_20622853_ChIP-Seq_HELA_Human1.04131958
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03837294
137GATA6_21074721_ChIP-Seq_CACO-2_Human1.03741424
138* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03211016
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02706039
140PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02555006
141RBPJ_21746931_ChIP-Seq_IB4_Human1.01609868
142NCOR1_26117541_ChIP-Seq_K562_Human1.01228157
143CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99970599
144TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99549258
145VDR_22108803_ChIP-Seq_LS180_Human0.99210229
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.98579891
147CREB1_26743006_Chip-Seq_LNCaP_Human0.98567141
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98356782
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97137097
150GATA1_19941826_ChIP-Seq_K562_Human0.96838498
151CJUN_26792858_Chip-Seq_BT549_Human0.96553204
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96125067
153CTCF_27219007_Chip-Seq_Bcells_Human0.95697270
154SMRT_27268052_Chip-Seq_Bcells_Human0.95308963
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.94648918
156BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94413787
157CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94294691
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93873545
159CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93589917
160* ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93518749
161GATA3_26560356_Chip-Seq_TH2_Human0.93468873
162FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91980902
163SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91558057
164FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91225032
165NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90427192
166ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88159531
167KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87606190
168* BCL6_27268052_Chip-Seq_Bcells_Human0.87451362
169RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87361672
170TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86502207
171RACK7_27058665_Chip-Seq_MCF-7_Human0.86426035
172FOXA2_19822575_ChIP-Seq_HepG2_Human0.85762498
173GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84994225
174STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84656585
175KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84652587
176HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83919379
177CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83884762
178BCOR_27268052_Chip-Seq_Bcells_Human0.83692725
179TP53_16413492_ChIP-PET_HCT116_Human0.81984244
180CBX2_22325352_ChIP-Seq_293T-Rex_Human0.80417078
181SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79084724
182CTCF_20526341_ChIP-Seq_ESCs_Human0.78215682
183P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.77873558
184BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77719603
185PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76590843
186HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76001771
187NFYB_21822215_ChIP-Seq_K562_Human0.75888811
188EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75099116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.99162297
2MP0008875_abnormal_xenobiotic_pharmacok5.52555108
3MP0002132_abnormal_respiratory_system5.08264968
4MP0002653_abnormal_ependyma_morphology3.85617354
5MP0009780_abnormal_chondrocyte_physiolo3.85437740
6MP0003436_decreased_susceptibility_to3.81104768
7MP0002277_abnormal_respiratory_mucosa3.28413583
8* MP0002419_abnormal_innate_immunity3.15094601
9MP0005058_abnormal_lysosome_morphology3.14027169
10MP0004133_heterotaxia3.12915136
11MP0004043_abnormal_pH_regulation2.88857329
12MP0010678_abnormal_skin_adnexa2.81414978
13MP0001835_abnormal_antigen_presentation2.79897954
14* MP0005025_abnormal_response_to2.75212222
15MP0009785_altered_susceptibility_to2.68723395
16MP0000685_abnormal_immune_system2.65811991
17MP0005000_abnormal_immune_tolerance2.63707057
18MP0001533_abnormal_skeleton_physiology2.59393987
19MP0003300_gastrointestinal_ulcer2.59385638
20* MP0005464_abnormal_platelet_physiology2.58074558
21MP0002148_abnormal_hypersensitivity_rea2.57445207
22MP0003724_increased_susceptibility_to2.53000886
23MP0005083_abnormal_biliary_tract2.47356148
24MP0005623_abnormal_meninges_morphology2.46805167
25MP0004019_abnormal_vitamin_homeostasis2.46731932
26MP0003183_abnormal_peptide_metabolism2.42043543
27MP0002796_impaired_skin_barrier2.33900788
28MP0001790_abnormal_immune_system2.29579637
29MP0005387_immune_system_phenotype2.29579637
30MP0001851_eye_inflammation2.28373571
31MP0004947_skin_inflammation2.28158923
32MP0000566_synostosis2.27779052
33* MP0002452_abnormal_antigen_presenting2.24016087
34MP0001800_abnormal_humoral_immune2.21811927
35MP0009840_abnormal_foam_cell2.20792718
36MP0008789_abnormal_olfactory_epithelium2.20217396
37MP0000678_abnormal_parathyroid_gland2.16499635
38MP0001984_abnormal_olfaction2.14294571
39MP0004264_abnormal_extraembryonic_tissu2.06952008
40MP0009278_abnormal_bone_marrow2.05999936
41MP0000383_abnormal_hair_follicle2.05553093
42* MP0002420_abnormal_adaptive_immunity2.04361770
43* MP0001819_abnormal_immune_cell2.01724488
44* MP0002723_abnormal_immune_serum2.00898489
45MP0010386_abnormal_urinary_bladder1.95839289
46MP0000343_altered_response_to1.94038780
47MP0003172_abnormal_lysosome_physiology1.89714452
48MP0003075_altered_response_to1.84781704
49MP0003566_abnormal_cell_adhesion1.84131979
50* MP0001845_abnormal_inflammatory_respons1.83983067
51MP0009333_abnormal_splenocyte_physiolog1.82777924
52MP0004272_abnormal_basement_membrane1.81631047
53MP0002405_respiratory_system_inflammati1.81070383
54MP0000465_gastrointestinal_hemorrhage1.79407501
55MP0004510_myositis1.74011022
56MP0001765_abnormal_ion_homeostasis1.71529663
57MP0002282_abnormal_trachea_morphology1.69045544
58MP0005165_increased_susceptibility_to1.66196809
59MP0002168_other_aberrant_phenotype1.66117710
60* MP0000716_abnormal_immune_system1.65091566
61MP0002166_altered_tumor_susceptibility1.63339255
62MP0004808_abnormal_hematopoietic_stem1.60084948
63MP0002006_tumorigenesis1.57926405
64MP0003950_abnormal_plasma_membrane1.57496538
65* MP0002398_abnormal_bone_marrow1.56551923
66MP0002139_abnormal_hepatobiliary_system1.54817958
67MP0001545_abnormal_hematopoietic_system1.54298512
68MP0005397_hematopoietic_system_phenotyp1.54298512
69MP0010155_abnormal_intestine_physiology1.48956552
70MP0005671_abnormal_response_to1.46819847
71MP0000689_abnormal_spleen_morphology1.46113749
72MP0001502_abnormal_circadian_rhythm1.45653843
73MP0002722_abnormal_immune_system1.45244327
74MP0002098_abnormal_vibrissa_morphology1.44816483
75MP0009379_abnormal_foot_pigmentation1.44146910
76MP0006082_CNS_inflammation1.44083901
77* MP0002429_abnormal_blood_cell1.40644915
78MP0003705_abnormal_hypodermis_morpholog1.37921886
79MP0010352_gastrointestinal_tract_polyps1.36559681
80MP0000762_abnormal_tongue_morphology1.36495694
81* MP0008469_abnormal_protein_level1.35153338
82MP0001853_heart_inflammation1.34309435
83MP0005076_abnormal_cell_differentiation1.33395989
84MP0000858_altered_metastatic_potential1.32362079
85MP0000681_abnormal_thyroid_gland1.30930352
86MP0000604_amyloidosis1.25787812
87MP0003448_altered_tumor_morphology1.23792165
88MP0003191_abnormal_cellular_cholesterol1.22762271
89MP0005394_taste/olfaction_phenotype1.20570974
90MP0005499_abnormal_olfactory_system1.20570974
91MP0010234_abnormal_vibrissa_follicle1.20220669
92MP0002249_abnormal_larynx_morphology1.19397697
93MP0002933_joint_inflammation1.18467328
94MP0005390_skeleton_phenotype1.18069411
95MP0002396_abnormal_hematopoietic_system1.17808239
96MP0001663_abnormal_digestive_system1.16783318
97MP0005636_abnormal_mineral_homeostasis1.16330446
98MP0005310_abnormal_salivary_gland1.16309210
99MP0005085_abnormal_gallbladder_physiolo1.15241275
100MP0008438_abnormal_cutaneous_collagen1.14810608
101MP0005501_abnormal_skin_physiology1.14705940
102MP0002877_abnormal_melanocyte_morpholog1.13727870
103MP0010307_abnormal_tumor_latency1.12374030
104MP0005377_hearing/vestibular/ear_phenot1.11719407
105MP0003878_abnormal_ear_physiology1.11719407
106MP0000490_abnormal_crypts_of1.11080551
107MP0005408_hypopigmentation1.09910983
108MP0002136_abnormal_kidney_physiology1.09452013
109MP0009643_abnormal_urine_homeostasis1.09191020
110MP0002998_abnormal_bone_remodeling1.06126289
111MP0001873_stomach_inflammation1.03604212
112MP0002060_abnormal_skin_morphology1.02064434
113MP0003656_abnormal_erythrocyte_physiolo1.00947603
114MP0000579_abnormal_nail_morphology0.98292112
115MP0003828_pulmonary_edema0.97681591
116MP0000249_abnormal_blood_vessel0.96265740
117MP0009764_decreased_sensitivity_to0.95233883
118* MP0005023_abnormal_wound_healing0.94468685
119MP0003941_abnormal_skin_development0.93199400
120MP0005174_abnormal_tail_pigmentation0.92143046
121MP0002089_abnormal_postnatal_growth/wei0.91568564
122MP0002876_abnormal_thyroid_physiology0.91248887
123MP0002160_abnormal_reproductive_system0.90974204
124MP0005166_decreased_susceptibility_to0.89071760
125MP0010771_integument_phenotype0.88257837
126MP0001270_distended_abdomen0.87591573
127MP0000467_abnormal_esophagus_morphology0.86871823
128MP0005395_other_phenotype0.85824804
129MP0001346_abnormal_lacrimal_gland0.84924769
130MP0008004_abnormal_stomach_pH0.84831737
131MP0001664_abnormal_digestion0.84060740
132* MP0009763_increased_sensitivity_to0.83285201
133MP0005365_abnormal_bile_salt0.83168704
134MP0004782_abnormal_surfactant_physiolog0.83125615
135MP0003195_calcinosis0.80951891
136MP0003221_abnormal_cardiomyocyte_apopto0.80313315
137MP0003453_abnormal_keratinocyte_physiol0.79711412
138MP0003795_abnormal_bone_structure0.79000919
139MP0005164_abnormal_response_to0.78929653
140MP0001849_ear_inflammation0.77903726
141MP0009931_abnormal_skin_appearance0.77672694
142MP0010030_abnormal_orbit_morphology0.75364771
143MP0003091_abnormal_cell_migration0.75040592
144MP0002019_abnormal_tumor_incidence0.74467343
145MP0008260_abnormal_autophagy0.73701815
146MP0001666_abnormal_nutrient_absorption0.73585555
147MP0009765_abnormal_xenobiotic_induced0.72695109
148MP0006054_spinal_hemorrhage0.71884222
149MP0005275_abnormal_skin_tensile0.71172490
150MP0001216_abnormal_epidermal_layer0.70176419
151MP0002233_abnormal_nose_morphology0.69621707
152MP0000703_abnormal_thymus_morphology0.69220539
153MP0001879_abnormal_lymphatic_vessel0.68710073
154MP0005084_abnormal_gallbladder_morpholo0.66987127
155MP0002133_abnormal_respiratory_system0.66105375
156MP0005388_respiratory_system_phenotype0.66105375
157MP0001915_intracranial_hemorrhage0.64891571
158MP0005381_digestive/alimentary_phenotyp0.64425866
159MP0008873_increased_physiological_sensi0.63182877
160MP0003252_abnormal_bile_duct0.63057221
161MP0001958_emphysema0.62473312
162MP0002896_abnormal_bone_mineralization0.61867893
163MP0003806_abnormal_nucleotide_metabolis0.59584967
164MP0002928_abnormal_bile_duct0.58770077
165MP0003186_abnormal_redox_activity0.56717745
166MP0000767_abnormal_smooth_muscle0.55049688
167MP0003638_abnormal_response/metabolism_0.54965174
168MP0000733_abnormal_muscle_development0.54745795
169MP0005621_abnormal_cell_physiology0.53985872
170MP0003045_fibrosis0.53366554
171MP0004883_abnormal_blood_vessel0.53187811
172MP0003866_abnormal_defecation0.52634015

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.90033197
2Absent/shortened dynein arms (HP:0200106)9.90033197
3Rhinitis (HP:0012384)9.84938617
4Chronic bronchitis (HP:0004469)8.23130665
5Eczematoid dermatitis (HP:0000976)7.49199506
6Bronchiectasis (HP:0002110)7.20317413
7Recurrent abscess formation (HP:0002722)6.88199829
8Recurrent gram-negative bacterial infections (HP:0005420)6.34545914
9Recurrent bacterial skin infections (HP:0005406)5.58407097
10Systemic lupus erythematosus (HP:0002725)5.38924262
11Bronchitis (HP:0012387)4.42994128
12Abnormality of macrophages (HP:0004311)4.22774806
13Recurrent sinusitis (HP:0011108)4.17641137
14Chronic obstructive pulmonary disease (HP:0006510)4.11995093
15Obstructive lung disease (HP:0006536)4.11995093
16Vacuolated lymphocytes (HP:0001922)4.01734294
17Mediastinal lymphadenopathy (HP:0100721)3.97391641
18Chronic sinusitis (HP:0011109)3.92045618
19Dysostosis multiplex (HP:0000943)3.89533312
20Male infertility (HP:0003251)3.81334313
21Infertility (HP:0000789)3.78571954
22Recurrent fungal infections (HP:0002841)3.78526726
23Recurrent otitis media (HP:0000403)3.76689798
24Gingivitis (HP:0000230)3.73005094
25Recurrent skin infections (HP:0001581)3.72236442
26Hyperactive renin-angiotensin system (HP:0000841)3.70296513
27Cellulitis (HP:0100658)3.67037327
28Interstitial pulmonary disease (HP:0006530)3.66186589
29Acute lymphatic leukemia (HP:0006721)3.56385551
30Spondylolisthesis (HP:0003302)3.51890144
31Elevated erythrocyte sedimentation rate (HP:0003565)3.48331930
32J-shaped sella turcica (HP:0002680)3.46544888
33Myositis (HP:0100614)3.42591559
34Pustule (HP:0200039)3.35833217
35Mucopolysacchariduria (HP:0008155)3.29852242
36Urinary glycosaminoglycan excretion (HP:0003541)3.29852242
37Occipital encephalocele (HP:0002085)3.20128317
38Cervical subluxation (HP:0003308)3.19418199
39Meningitis (HP:0001287)3.16521372
40Stomatitis (HP:0010280)3.15974717
41Chronic otitis media (HP:0000389)3.06640377
42Urticaria (HP:0001025)3.00368139
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.95560735
44Abnormality of polysaccharide metabolism (HP:0011012)2.95560735
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.95560735
46Atelectasis (HP:0100750)2.94961520
47Osteolytic defects of the hand bones (HP:0009699)2.91481015
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.91481015
49Papilledema (HP:0001085)2.90266802
50Thoracic kyphosis (HP:0002942)2.88445256
51Periodontitis (HP:0000704)2.85376782
52Orchitis (HP:0100796)2.84477338
53Abnormality of the lumbar spine (HP:0100712)2.83961687
54Glomerulonephritis (HP:0000099)2.81924666
55Osteomyelitis (HP:0002754)2.77022011
56True hermaphroditism (HP:0010459)2.72993905
57Recurrent cutaneous fungal infections (HP:0011370)2.72869144
58Chronic mucocutaneous candidiasis (HP:0002728)2.72869144
59Abnormality of complement system (HP:0005339)2.70169145
60Recurrent viral infections (HP:0004429)2.66109425
61Nasal polyposis (HP:0100582)2.65794909
62Absent frontal sinuses (HP:0002688)2.65614093
63IgM deficiency (HP:0002850)2.65363585
64Pancreatic fibrosis (HP:0100732)2.61096167
65Prolonged bleeding time (HP:0003010)2.59865660
66Thrombocytosis (HP:0001894)2.59027531
67Peritonitis (HP:0002586)2.51916446
68Arterial thrombosis (HP:0004420)2.49189720
69Leukocytosis (HP:0001974)2.48548065
70Menorrhagia (HP:0000132)2.48127355
71Bell-shaped thorax (HP:0001591)2.43180582
72Verrucae (HP:0200043)2.40865964
73Papilloma (HP:0012740)2.40865964
74Renal salt wasting (HP:0000127)2.39472655
75Increased IgE level (HP:0003212)2.36576857
76Deformed sella turcica (HP:0002681)2.33094516
77Inflammation of the large intestine (HP:0002037)2.32878996
78Abnormality of the nasal mucosa (HP:0000433)2.32720000
79Retrobulbar optic neuritis (HP:0100654)2.31108109
80Optic neuritis (HP:0100653)2.31108109
81Petechiae (HP:0000967)2.30357476
82Abnormality of the thoracic spine (HP:0100711)2.29055502
83Gastrointestinal infarctions (HP:0005244)2.27832058
84Cutaneous melanoma (HP:0012056)2.25869072
85Pancreatic cysts (HP:0001737)2.24887247
86Cystic liver disease (HP:0006706)2.23294321
87Molar tooth sign on MRI (HP:0002419)2.23181475
88Abnormality of midbrain morphology (HP:0002418)2.23181475
89Vasculitis (HP:0002633)2.21735903
90Gastrointestinal inflammation (HP:0004386)2.20382781
91Colitis (HP:0002583)2.20191981
92Chest pain (HP:0100749)2.18930655
93Thickened calvaria (HP:0002684)2.17938195
94Nephritis (HP:0000123)2.16860701
95Epistaxis (HP:0000421)2.16438497
96Tubulointerstitial nephritis (HP:0001970)2.12291831
97Severe short stature (HP:0003510)2.11513092
98Increased density of long bones (HP:0006392)2.09739145
99Spontaneous hematomas (HP:0007420)2.07974330
100Abnormal platelet volume (HP:0011876)2.07236436
101Sepsis (HP:0100806)2.06593013
102Hyperkalemia (HP:0002153)2.06339105
103Thoracolumbar scoliosis (HP:0002944)2.05458696
104Decreased circulating renin level (HP:0003351)2.04228176
105Broad face (HP:0000283)2.03828623
106Recurrent pneumonia (HP:0006532)2.03621618
107Skin ulcer (HP:0200042)2.01991577
108Gingival bleeding (HP:0000225)2.01760158
109Impaired platelet aggregation (HP:0003540)2.01533258
110Abnormal platelet function (HP:0011869)2.01533258
111Ulnar deviation of the wrist (HP:0003049)2.01405750
112Nephronophthisis (HP:0000090)2.00821822
113Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0702281
114Abnormal respiratory motile cilium physiology (HP:0012261)10.5357532
115Abnormal respiratory motile cilium morphology (HP:0005938)10.4022669
116Abnormal respiratory epithelium morphology (HP:0012253)10.4022669
117Abnormal ciliary motility (HP:0012262)10.1982869
118Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.99459117
119Syringomyelia (HP:0003396)1.97622383
120Spinal cord lesions (HP:0100561)1.97622383
121Abnormal delayed hypersensitivity skin test (HP:0002963)1.96460085
122Restrictive lung disease (HP:0002091)1.95507859
123Chronic hepatic failure (HP:0100626)1.94699658
124Eosinophilia (HP:0001880)1.92814893
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.92134616
126Shallow orbits (HP:0000586)1.90897092
127Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90218490
128Lip pit (HP:0100267)1.89936233
129Increased cerebral lipofuscin (HP:0011813)1.89418833
130Complement deficiency (HP:0004431)1.88151775
131Cerebral aneurysm (HP:0004944)1.86838531
132Persistence of primary teeth (HP:0006335)1.84505594
133Abnormality of the common coagulation pathway (HP:0010990)1.83669050
134Recurrent bronchitis (HP:0002837)1.81650258
135Tubular atrophy (HP:0000092)1.79977516
136Postaxial foot polydactyly (HP:0001830)1.78751970
137Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.77205211
138Hyperaldosteronism (HP:0000859)1.73559908
139Abnormality of the renal medulla (HP:0100957)1.73160879
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.69936817
141Abnormality of chloride homeostasis (HP:0011422)1.67308876
142Flat acetabular roof (HP:0003180)1.63328667
143Popliteal pterygium (HP:0009756)1.62153327
144Abnormality of renin-angiotensin system (HP:0000847)1.62093966
145Vascular calcification (HP:0004934)1.61951347
146Congenital hepatic fibrosis (HP:0002612)1.58089585
147Glucose intolerance (HP:0000833)1.57567854
148Abnormality of monocarboxylic acid metabolism (HP:0010996)1.56234429
149Medial flaring of the eyebrow (HP:0010747)1.55351815
150Male pseudohermaphroditism (HP:0000037)1.54966000
151Abnormality of the distal phalanges of the toes (HP:0010182)1.52896153
152Nephropathy (HP:0000112)1.52604055
153Congenital primary aphakia (HP:0007707)1.52050137
154Furrowed tongue (HP:0000221)1.52048593
155Anencephaly (HP:0002323)1.50941349
156Abnormality of permanent molar morphology (HP:0011071)1.50632501
157Abnormality of the dental root (HP:0006486)1.50632501
158Taurodontia (HP:0000679)1.50632501
159Muscle fiber splitting (HP:0003555)1.44413805
160Gait imbalance (HP:0002141)1.43864860
161Fibular aplasia (HP:0002990)1.42772353
162Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.42273989
163Cardiovascular calcification (HP:0011915)1.40863249
164Abnormality of molar (HP:0011077)1.40522490
165Abnormality of molar morphology (HP:0011070)1.40522490
166Distal lower limb muscle weakness (HP:0009053)1.39174649
167Hyponatremia (HP:0002902)1.37348487
168Abnormality of the dental pulp (HP:0006479)1.35332711
169Short thorax (HP:0010306)1.31661985
170Aplasia/hypoplasia of the uterus (HP:0008684)1.31494007
171Onycholysis (HP:0001806)1.31028809
172Nephrogenic diabetes insipidus (HP:0009806)1.30968674
173Hand muscle atrophy (HP:0009130)1.30882957
174Barrel-shaped chest (HP:0001552)1.28891048
175Cone-rod dystrophy (HP:0000548)1.27908604
176Hypokalemic alkalosis (HP:0001949)1.26380594
177Median cleft lip (HP:0000161)1.25793142
178Asplenia (HP:0001746)1.24982703
179Aplasia/Hypoplasia of the spleen (HP:0010451)1.23862736
180Carpal bone hypoplasia (HP:0001498)1.23739626
181Oculomotor apraxia (HP:0000657)1.23098328
182Tubulointerstitial fibrosis (HP:0005576)1.23015837
183Bifid scrotum (HP:0000048)1.22818827
184Postaxial hand polydactyly (HP:0001162)1.20887439
185Stage 5 chronic kidney disease (HP:0003774)1.19308719
186Decreased central vision (HP:0007663)1.16859059
187Short nail (HP:0001799)1.14478416
188Tubulointerstitial abnormality (HP:0001969)1.14122183
189Disproportionate short-trunk short stature (HP:0003521)1.12780317
190Hypoplasia of the uterus (HP:0000013)1.12079597
191Split foot (HP:0001839)1.10751550
192Abnormality of macular pigmentation (HP:0008002)1.09888910
193Spinal cord compression (HP:0002176)1.09615167
194Abnormality of sodium homeostasis (HP:0010931)1.07893099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.91778359
2EPHA26.96767540
3MST45.40519447
4BLK3.53862195
5IRAK43.43580738
6ERN13.12092723
7EPHB12.85814951
8TAOK32.85639153
9MAP4K12.74262129
10MAP3K22.67284084
11RIPK42.57851731
12MST1R2.53907309
13TRIB32.53132032
14TTN2.51385034
15STK242.50276358
16FES2.46677937
17GRK62.42785065
18STK102.28083309
19MAP3K32.26223088
20BTK2.15408736
21MAPKAPK32.12169094
22TESK22.09950399
23TEC2.08417979
24TESK12.07308306
25MAP3K142.04214897
26PKN21.98617362
27BCR1.83869970
28LRRK21.83292062
29MAP3K121.73419526
30TBK11.72389451
31MAP2K31.68977298
32KIT1.60929784
33TRPM71.60142571
34EEF2K1.55371643
35SYK1.53894931
36LIMK11.52954834
37LMTK21.51432530
38SMG11.48678285
39NME11.44010135
40MYLK1.42655226
41CAMK1D1.42445957
42CAMK1G1.41250990
43RIPK11.37964432
44PAK41.34588065
45EPHA31.34553625
46ZAP701.34221497
47MAPK41.31593274
48TYK21.31380516
49HCK1.29782206
50SIK21.28983852
51CSK1.28828956
52EIF2AK31.25883631
53PTK61.18844691
54IRAK31.16686499
55EPHB21.15598474
56BMX1.11850680
57ITK1.06050782
58RPS6KA41.03918683
59MAP3K111.01520573
60ARAF1.00381486
61CSF1R0.98086783
62LCK0.97512071
63NEK60.96817217
64LATS10.91990355
65CLK10.91774424
66LYN0.90368498
67MAP3K60.90363701
68RPS6KC10.90143881
69RPS6KL10.90143881
70TLK10.89906306
71ERBB30.89368322
72RPS6KA20.89244302
73RPS6KA60.89101997
74NEK20.87141714
75MARK30.83741713
76PIM10.82771243
77PTK20.82462657
78STK380.81825194
79PIM20.80850490
80ERBB20.79925066
81ALK0.78991028
82MAP3K70.78004375
83STK38L0.76622412
84MARK20.75505004
85PRKCI0.73317183
86IKBKB0.71408019
87SCYL20.71361207
88FER0.70446914
89FGR0.68974219
90MAP3K80.68650639
91TTK0.68444843
92IKBKE0.67720317
93STK390.65730790
94MATK0.64452130
95DAPK10.63823525
96PKN10.62350376
97PTK2B0.61043580
98CAMK2G0.60182556
99MAP3K130.60076710
100MAPKAPK20.59997985
101PRKCH0.59990834
102JAK10.59735322
103IRAK10.57669041
104TXK0.56817231
105FGFR30.56088454
106MAP3K100.54230706
107LATS20.53216291
108CDK120.52823151
109ROCK20.52654764
110BMPR20.52591454
111ADRBK10.51626486
112CDK40.51236892
113PIK3CG0.49655987
114PRKCD0.49282601
115JAK20.47750413
116CHUK0.47176366
117EGFR0.47162277
118STK160.47084429
119WNK40.45632227
120CDC42BPA0.45513017
121SIK30.44400503
122NTRK10.44158999
123PDPK10.43996441
124DMPK0.43117749
125HIPK20.42357914
126MELK0.41655847
127PDGFRB0.40014560
128FYN0.39639354
129ILK0.39249598
130CDC70.39150030
131CAMKK10.38940096
132RPS6KB20.36246931
133MAP3K10.35673324
134PRKCQ0.34379173
135NLK0.33919475
136TAOK20.33697016
137PBK0.32312442
138BRSK20.31876608
139CDK60.31609778
140PDK10.31552220
141DAPK30.31208545
142ABL10.31031541
143DYRK1B0.30856186
144ABL20.30411017
145ROCK10.30323155
146MET0.29517655
147PAK10.26947082
148ERBB40.26733190
149TAOK10.26463831
150PRKD10.26000733
151ATR0.25995115
152PRKG20.25905183
153KDR0.25338571
154IGF1R0.24827308
155ICK0.23924379
156SGK10.23676952
157CDK80.22722814
158AKT20.22514716
159PRKD20.21850663
160PRKCE0.21695738
161PRKAA20.21418608
162MAP2K10.20936773
163PRKCA0.20488962
164MAP2K60.19049876
165SRC0.16773157
166GRK10.15942965

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.88339496
2Staphylococcus aureus infection_Homo sapiens_hsa051504.58156881
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.55620425
4Phenylalanine metabolism_Homo sapiens_hsa003604.26560614
5Chemical carcinogenesis_Homo sapiens_hsa052043.93923891
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.93471196
7Leishmaniasis_Homo sapiens_hsa051403.83962093
8Other glycan degradation_Homo sapiens_hsa005113.36181544
9Tyrosine metabolism_Homo sapiens_hsa003503.35565155
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.84564501
11Pertussis_Homo sapiens_hsa051332.83312775
12Retinol metabolism_Homo sapiens_hsa008302.68384985
13beta-Alanine metabolism_Homo sapiens_hsa004102.51831969
14Legionellosis_Homo sapiens_hsa051342.46276671
15Sphingolipid metabolism_Homo sapiens_hsa006002.25815285
16Osteoclast differentiation_Homo sapiens_hsa043802.15576888
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.03970640
18Malaria_Homo sapiens_hsa051442.03575792
19Tuberculosis_Homo sapiens_hsa051522.03508253
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89274541
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.89089989
22Lysosome_Homo sapiens_hsa041421.88737740
23Hematopoietic cell lineage_Homo sapiens_hsa046401.83544924
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83210685
25Salmonella infection_Homo sapiens_hsa051321.82191241
26Phagosome_Homo sapiens_hsa041451.75464129
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.71969852
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.71949223
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71255351
30Huntingtons disease_Homo sapiens_hsa050161.68065432
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63897278
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.60207479
33Complement and coagulation cascades_Homo sapiens_hsa046101.60185247
34B cell receptor signaling pathway_Homo sapiens_hsa046621.59072324
35Tight junction_Homo sapiens_hsa045301.57222846
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56230445
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49616726
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.44765829
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42698261
40Circadian rhythm_Homo sapiens_hsa047101.41106135
41Linoleic acid metabolism_Homo sapiens_hsa005911.32868294
42Amoebiasis_Homo sapiens_hsa051461.31679425
43Toxoplasmosis_Homo sapiens_hsa051451.31388100
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31386731
45Shigellosis_Homo sapiens_hsa051311.30023529
46Chemokine signaling pathway_Homo sapiens_hsa040621.29595117
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28951561
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25128243
49Pentose phosphate pathway_Homo sapiens_hsa000301.25016563
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.24100893
51Apoptosis_Homo sapiens_hsa042101.15699336
52Rheumatoid arthritis_Homo sapiens_hsa053231.15117368
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13650280
54Caffeine metabolism_Homo sapiens_hsa002321.13600388
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12313974
56Graft-versus-host disease_Homo sapiens_hsa053321.06859000
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06827352
58Antigen processing and presentation_Homo sapiens_hsa046121.05763999
59TNF signaling pathway_Homo sapiens_hsa046681.04023449
60Platelet activation_Homo sapiens_hsa046111.02040621
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01360862
62Fatty acid degradation_Homo sapiens_hsa000710.94972236
63Measles_Homo sapiens_hsa051620.91784838
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90559454
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90505955
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.90262084
67Adherens junction_Homo sapiens_hsa045200.88166897
68Viral myocarditis_Homo sapiens_hsa054160.86460619
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84286531
70Chronic myeloid leukemia_Homo sapiens_hsa052200.83865219
71Galactose metabolism_Homo sapiens_hsa000520.82049600
72Histidine metabolism_Homo sapiens_hsa003400.81457039
73VEGF signaling pathway_Homo sapiens_hsa043700.81000395
74N-Glycan biosynthesis_Homo sapiens_hsa005100.80456263
75Hepatitis B_Homo sapiens_hsa051610.80441570
76Influenza A_Homo sapiens_hsa051640.79918171
77Starch and sucrose metabolism_Homo sapiens_hsa005000.79859696
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78453786
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77474216
80Acute myeloid leukemia_Homo sapiens_hsa052210.73973740
81Herpes simplex infection_Homo sapiens_hsa051680.73887040
82Prion diseases_Homo sapiens_hsa050200.73709535
83Peroxisome_Homo sapiens_hsa041460.71592139
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.70715070
85Arachidonic acid metabolism_Homo sapiens_hsa005900.70555893
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70423752
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69546415
88Allograft rejection_Homo sapiens_hsa053300.69499505
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69138995
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.69053512
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.68044888
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66060806
93ECM-receptor interaction_Homo sapiens_hsa045120.65011921
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64986719
95Asthma_Homo sapiens_hsa053100.63769213
96Pancreatic cancer_Homo sapiens_hsa052120.63354806
97African trypanosomiasis_Homo sapiens_hsa051430.62816030
98Type I diabetes mellitus_Homo sapiens_hsa049400.61229524
99Nitrogen metabolism_Homo sapiens_hsa009100.58868194
100HIF-1 signaling pathway_Homo sapiens_hsa040660.58469194
101DNA replication_Homo sapiens_hsa030300.57987422
102Proteoglycans in cancer_Homo sapiens_hsa052050.55884814
103Salivary secretion_Homo sapiens_hsa049700.55717718
104Choline metabolism in cancer_Homo sapiens_hsa052310.53126248
105Lysine degradation_Homo sapiens_hsa003100.52942311
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51272086
107Non-small cell lung cancer_Homo sapiens_hsa052230.50961371
108Glutathione metabolism_Homo sapiens_hsa004800.50350095
109Hepatitis C_Homo sapiens_hsa051600.50181222
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49693568
111Small cell lung cancer_Homo sapiens_hsa052220.48688971
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.48364179
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48253164
114Collecting duct acid secretion_Homo sapiens_hsa049660.47158965
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46498396
116Primary immunodeficiency_Homo sapiens_hsa053400.45347082
117Arginine and proline metabolism_Homo sapiens_hsa003300.44964656
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43634678
119ABC transporters_Homo sapiens_hsa020100.43410627
120Mineral absorption_Homo sapiens_hsa049780.38284091
121HTLV-I infection_Homo sapiens_hsa051660.37759115
122Viral carcinogenesis_Homo sapiens_hsa052030.36688049
123Bile secretion_Homo sapiens_hsa049760.36667880
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.36328879
125Glycerolipid metabolism_Homo sapiens_hsa005610.36216479
126Vibrio cholerae infection_Homo sapiens_hsa051100.35316351
127Vitamin B6 metabolism_Homo sapiens_hsa007500.32365076
128Hedgehog signaling pathway_Homo sapiens_hsa043400.31168310
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.29201877
130Endocytosis_Homo sapiens_hsa041440.29171604
131T cell receptor signaling pathway_Homo sapiens_hsa046600.28946932
132Epstein-Barr virus infection_Homo sapiens_hsa051690.28806839
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28676481
134p53 signaling pathway_Homo sapiens_hsa041150.28366513
135Notch signaling pathway_Homo sapiens_hsa043300.28298053
136Arginine biosynthesis_Homo sapiens_hsa002200.27755826
137Renal cell carcinoma_Homo sapiens_hsa052110.27592166
138Thyroid hormone synthesis_Homo sapiens_hsa049180.27225049
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27106344
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27103085
141Focal adhesion_Homo sapiens_hsa045100.26881160
142Insulin resistance_Homo sapiens_hsa049310.26605934
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.26070080
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26017299
145Type II diabetes mellitus_Homo sapiens_hsa049300.25644538
146Metabolic pathways_Homo sapiens_hsa011000.21022515
147Phototransduction_Homo sapiens_hsa047440.18894453
148Autoimmune thyroid disease_Homo sapiens_hsa053200.16079654
149Fructose and mannose metabolism_Homo sapiens_hsa000510.15685387

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