SLK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)4.77785165
2nuclear pore organization (GO:0006999)4.43702847
3pore complex assembly (GO:0046931)3.89096457
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.73061099
5cytoplasmic mRNA processing body assembly (GO:0033962)3.70290332
6cytoskeletal anchoring at plasma membrane (GO:0007016)3.33400279
7regulation of transforming growth factor beta2 production (GO:0032909)3.31934133
8plasma membrane repair (GO:0001778)3.29872279
9embryonic process involved in female pregnancy (GO:0060136)3.29633635
10keratinization (GO:0031424)3.22723788
11growth hormone receptor signaling pathway (GO:0060396)3.18794946
12establishment of skin barrier (GO:0061436)3.16724510
13negative regulation of DNA repair (GO:0045738)3.16248793
14histone H3-K4 trimethylation (GO:0080182)3.13407176
15regulation of water loss via skin (GO:0033561)3.09532604
16keratinocyte differentiation (GO:0030216)3.07863863
17hemidesmosome assembly (GO:0031581)3.07768547
18cardiac myofibril assembly (GO:0055003)3.05332614
19cell adhesion mediated by integrin (GO:0033627)2.98411133
20surfactant homeostasis (GO:0043129)2.96763108
21mitotic sister chromatid cohesion (GO:0007064)2.95663459
22cortical actin cytoskeleton organization (GO:0030866)2.93929633
23chemical homeostasis within a tissue (GO:0048875)2.89426973
24early endosome to late endosome transport (GO:0045022)2.86973030
25keratinocyte proliferation (GO:0043616)2.86908502
26establishment of endothelial barrier (GO:0061028)2.85420543
27negative regulation of fatty acid transport (GO:2000192)2.85402222
28interkinetic nuclear migration (GO:0022027)2.84897521
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82961395
30regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.82676546
31sarcomere organization (GO:0045214)2.81821716
32negative regulation of keratinocyte proliferation (GO:0010839)2.81496330
33mammary gland epithelial cell proliferation (GO:0033598)2.80407136
34peptide cross-linking (GO:0018149)2.78981915
35negative regulation of potassium ion transmembrane transport (GO:1901380)2.78268571
36mesodermal cell differentiation (GO:0048333)2.75521341
37regulation of RNA export from nucleus (GO:0046831)2.74696151
38negative regulation of anoikis (GO:2000811)2.74528444
39positive regulation of histone deacetylation (GO:0031065)2.73006893
40monoubiquitinated protein deubiquitination (GO:0035520)2.72023457
41regulation of transforming growth factor beta1 production (GO:0032908)2.71757885
42positive regulation of p38MAPK cascade (GO:1900745)2.70089776
43positive regulation of Rho protein signal transduction (GO:0035025)2.69443171
44definitive hemopoiesis (GO:0060216)2.69078968
45positive regulation of cellular response to insulin stimulus (GO:1900078)2.68497383
46cellular response to growth hormone stimulus (GO:0071378)2.67058145
47mRNA transcription (GO:0009299)2.65855840
48COPII vesicle coating (GO:0048208)2.65539512
49myofibril assembly (GO:0030239)2.65523246
50hypotonic response (GO:0006971)2.64221062
51peptidyl-tyrosine autophosphorylation (GO:0038083)2.62879799
52macroautophagy (GO:0016236)2.60334536
53regulation of nucleobase-containing compound transport (GO:0032239)2.60049995
54cell-substrate junction assembly (GO:0007044)2.60043440
55retrograde transport, vesicle recycling within Golgi (GO:0000301)2.59582232
56negative regulation of complement activation (GO:0045916)2.59073502
57renal filtration (GO:0097205)2.58846671
58nuclear pore complex assembly (GO:0051292)2.57804993
59regulation of p38MAPK cascade (GO:1900744)2.57785232
60regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.57445022
61insulin-like growth factor receptor signaling pathway (GO:0048009)2.55930184
62intestinal epithelial cell development (GO:0060576)2.54755645
63regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.54423421
64angiogenesis involved in wound healing (GO:0060055)2.52977942
65phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.52216254
66positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51171635
67NLS-bearing protein import into nucleus (GO:0006607)2.50778543
68retina vasculature morphogenesis in camera-type eye (GO:0061299)2.50099188
69negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.49975547
70positive regulation of receptor recycling (GO:0001921)2.49818430
71vascular endothelial growth factor signaling pathway (GO:0038084)2.49782040
72peptidyl-threonine modification (GO:0018210)2.49288734
73epidermal cell differentiation (GO:0009913)2.48186033
74cortical cytoskeleton organization (GO:0030865)2.47723631
75glomerular filtration (GO:0003094)2.46126685
76embryonic retina morphogenesis in camera-type eye (GO:0060059)2.46032953
77positive regulation of insulin receptor signaling pathway (GO:0046628)2.46004346
78positive regulation of macroautophagy (GO:0016239)2.44737220
79germ cell migration (GO:0008354)2.44371343
80regulation of protein polyubiquitination (GO:1902914)2.43743209
81hepatocyte apoptotic process (GO:0097284)2.42992274
82membrane raft organization (GO:0031579)2.42098558
83regulation of DNA endoreduplication (GO:0032875)2.40919913
84integrin-mediated signaling pathway (GO:0007229)2.39857425
85epithelial cell-cell adhesion (GO:0090136)2.39675433
86Golgi transport vesicle coating (GO:0048200)2.38715811
87COPI coating of Golgi vesicle (GO:0048205)2.38715811
88platelet-derived growth factor receptor signaling pathway (GO:0048008)2.36467923
89focal adhesion assembly (GO:0048041)2.36205337
90cell-substrate adherens junction assembly (GO:0007045)2.36205337
91regulation of keratinocyte differentiation (GO:0045616)2.36032560
92regulation of interleukin-12 biosynthetic process (GO:0045075)2.34456965
93positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.33782211
94regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.33782211
95activation of Rac GTPase activity (GO:0032863)2.33132490
96positive regulation of natural killer cell differentiation (GO:0032825)2.32718234
97peptidyl-threonine phosphorylation (GO:0018107)2.32714602
98bundle of His cell to Purkinje myocyte communication (GO:0086069)2.32617159
99nerve growth factor signaling pathway (GO:0038180)2.32527622
100response to laminar fluid shear stress (GO:0034616)2.32301193
101positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.31923123
102coronary vasculature morphogenesis (GO:0060977)2.31922800
103iron ion import (GO:0097286)2.31760415
104regulation of anoikis (GO:2000209)2.31697691
105apoptotic cell clearance (GO:0043277)2.30910089
106negative regulation of protein localization to plasma membrane (GO:1903077)2.29870637
107blood vessel maturation (GO:0001955)2.29311024
108megakaryocyte development (GO:0035855)2.28848505
109dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.28708609
110regulation of glucocorticoid metabolic process (GO:0031943)2.28420729
111interleukin-6-mediated signaling pathway (GO:0070102)2.28369870
112actomyosin structure organization (GO:0031032)2.27342376
113gap junction assembly (GO:0016264)2.25989399
114desmosome organization (GO:0002934)2.25839399
115mRNA transcription from RNA polymerase II promoter (GO:0042789)2.25817938
116morphogenesis of an epithelial sheet (GO:0002011)2.25309990
117pinocytosis (GO:0006907)2.25301094
118protein targeting to Golgi (GO:0000042)2.25109649
119semaphorin-plexin signaling pathway (GO:0071526)2.24608652
120heart morphogenesis (GO:0003007)2.24549130
121negative regulation of protein activation cascade (GO:2000258)2.23243659
122protein localization to microtubule (GO:0035372)2.23092678
123import into cell (GO:0098657)2.23027717
124regulation of Rac protein signal transduction (GO:0035020)2.22119559
125Golgi to plasma membrane protein transport (GO:0043001)2.21915750
126heterotypic cell-cell adhesion (GO:0034113)2.21608701
127wound healing, spreading of epidermal cells (GO:0035313)2.20529261
128vesicle coating (GO:0006901)2.20211557
129histone H2B ubiquitination (GO:0033523)2.19533429
130phospholipid translocation (GO:0045332)2.19155841
131lipid translocation (GO:0034204)2.19155841
132regulation of transforming growth factor beta production (GO:0071634)2.19061905
133negative regulation of vascular permeability (GO:0043116)2.18959567
134response to fluid shear stress (GO:0034405)2.18539186
135Golgi to plasma membrane transport (GO:0006893)2.18492871
136endothelial cell morphogenesis (GO:0001886)2.18411556
137regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.17975696
138positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.17975696
139substrate-dependent cell migration (GO:0006929)2.17878654
140positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.17375357
141glomerular visceral epithelial cell development (GO:0072015)2.16953731
142positive regulation of protein import into nucleus, translocation (GO:0033160)2.16856547
143cellular response to osmotic stress (GO:0071470)2.16725752
144actin filament-based movement (GO:0030048)2.16585735
145stress fiber assembly (GO:0043149)2.16394863
146embryonic viscerocranium morphogenesis (GO:0048703)2.15543230
147establishment of protein localization to Golgi (GO:0072600)2.15533526
148pathway-restricted SMAD protein phosphorylation (GO:0060389)2.15098999
149leukocyte migration involved in inflammatory response (GO:0002523)2.14102825
150adherens junction assembly (GO:0034333)2.13979225
151viral entry into host cell (GO:0046718)2.13971539
152glucocorticoid receptor signaling pathway (GO:0042921)2.13223468
153negative regulation of neurotransmitter secretion (GO:0046929)2.12827806
154adhesion of symbiont to host cell (GO:0044650)2.12298657
155virion attachment to host cell (GO:0019062)2.12298657
156positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.11914774
157regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.10368934
158regulation of cell communication by electrical coupling (GO:0010649)2.09574403
159regulation of sarcomere organization (GO:0060297)2.09377749
160regulation of cardioblast differentiation (GO:0051890)2.08890750
161cell migration involved in sprouting angiogenesis (GO:0002042)2.08835063
162regulation of necroptotic process (GO:0060544)2.07135655
163skin morphogenesis (GO:0043589)2.06571360
164regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.06256313
165hippo signaling (GO:0035329)2.04293388
166corticosteroid receptor signaling pathway (GO:0031958)2.03374938
167striated muscle atrophy (GO:0014891)2.02806438
168histone H3-K9 demethylation (GO:0033169)2.02646414
169regulation of ARF GTPase activity (GO:0032312)2.02017775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.62964613
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.49811153
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84820832
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.71327821
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.64817608
6FOXO3_23340844_ChIP-Seq_DLD1_Human2.16266362
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15000955
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.13182471
9GATA1_22025678_ChIP-Seq_K562_Human2.11274780
10AR_21909140_ChIP-Seq_LNCAP_Human2.06929149
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03817407
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96275847
13BP1_19119308_ChIP-ChIP_Hs578T_Human1.92650994
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92152466
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.90207510
16MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89989388
17TP53_16413492_ChIP-PET_HCT116_Human1.87239451
18GATA2_21666600_ChIP-Seq_HMVEC_Human1.84142861
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83357631
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.82638704
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.78730126
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77781690
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.77317455
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77041199
25SCL_19346495_ChIP-Seq_HPC-7_Human1.76638934
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75418797
27RUNX_20019798_ChIP-Seq_JUKART_Human1.73094861
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72253620
29* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72224072
30FOXM1_26456572_ChIP-Seq_MCF-7_Human1.68825590
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68810881
32TCF7_22412390_ChIP-Seq_EML_Mouse1.64491983
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.64308390
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63618206
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60913553
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59037064
37CLOCK_20551151_ChIP-Seq_293T_Human1.57355423
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.56998547
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56874736
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56874736
41* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56462552
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54903899
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.50870307
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.50870307
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.50730635
46SPI1_23127762_ChIP-Seq_K562_Human1.48347444
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48156969
48* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45464254
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45309361
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45264372
51* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43349587
52* TP63_23658742_ChIP-Seq_EP156T_Human1.41941349
53KDM2B_26808549_Chip-Seq_DND41_Human1.40880023
54GATA1_19941826_ChIP-Seq_K562_Human1.39428615
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39164915
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38055758
57VDR_24787735_ChIP-Seq_THP-1_Human1.36478041
58* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35403516
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34260634
60CJUN_26792858_Chip-Seq_BT549_Human1.34180954
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33851504
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.33758045
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33301974
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32509724
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.32362323
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32192227
67* BRD4_25478319_ChIP-Seq_HGPS_Human1.31450342
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31169940
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.31001965
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.30904031
71* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30877028
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29992844
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.29434207
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29381470
75FOXM1_23109430_ChIP-Seq_U2OS_Human1.29217743
76* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27358849
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26680850
78PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.26550551
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25705357
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25477588
81GATA2_19941826_ChIP-Seq_K562_Human1.25068316
82* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24960248
83VDR_24763502_ChIP-Seq_THP-1_Human1.24821559
84ZNF263_19887448_ChIP-Seq_K562_Human1.22360896
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21688449
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20858540
87* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20016986
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19023617
89VDR_21846776_ChIP-Seq_THP-1_Human1.18768979
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18343199
91AHR_22903824_ChIP-Seq_MCF-7_Human1.17844918
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.17599142
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.17579370
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16321081
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15733342
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15184843
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14317029
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14113963
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.13886960
100FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12641308
101* MAF_26560356_Chip-Seq_TH1_Human1.10852891
102NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10832410
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10213629
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10213629
105* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08365915
106FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07922405
107* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07555717
108GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05933283
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05752362
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05664885
111* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04754144
112RXR_22108803_ChIP-Seq_LS180_Human1.03638652
113GATA6_25053715_ChIP-Seq_YYC3_Human1.03348214
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03274438
115CHD1_26751641_Chip-Seq_LNCaP_Human1.02484447
116SOX2_20726797_ChIP-Seq_SW620_Human1.01855417
117GATA3_24758297_ChIP-Seq_MCF-7_Human1.01060016
118E2F7_22180533_ChIP-Seq_HELA_Human0.99281399
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98400620
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98056271
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97943356
122EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97723903
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96719055
124* ATF3_27146783_Chip-Seq_COLON_Human0.95539418
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92807770
126* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92345523
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89862198
128CDX2_20551321_ChIP-Seq_CACO-2_Human0.89648689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.53048350
2MP0003300_gastrointestinal_ulcer3.29999197
3MP0003950_abnormal_plasma_membrane3.16131077
4MP0008057_abnormal_DNA_replication2.92685876
5MP0003705_abnormal_hypodermis_morpholog2.87225635
6MP0003566_abnormal_cell_adhesion2.65005859
7MP0008438_abnormal_cutaneous_collagen2.48901824
8MP0004084_abnormal_cardiac_muscle2.46116051
9MP0005409_darkened_coat_color2.38478011
10MP0002877_abnormal_melanocyte_morpholog2.16806254
11MP0003828_pulmonary_edema2.14467947
12MP0003303_peritoneal_inflammation2.10545901
13MP0010234_abnormal_vibrissa_follicle2.09916005
14MP0003045_fibrosis2.08915200
15MP0010678_abnormal_skin_adnexa1.96326064
16MP0010630_abnormal_cardiac_muscle1.96097466
17MP0005076_abnormal_cell_differentiation1.94179019
18MP0000579_abnormal_nail_morphology1.92831520
19MP0010368_abnormal_lymphatic_system1.92518144
20MP0004185_abnormal_adipocyte_glucose1.90942721
21MP0000733_abnormal_muscle_development1.89973293
22MP0003941_abnormal_skin_development1.89895181
23MP0000751_myopathy1.89780343
24MP0002166_altered_tumor_susceptibility1.84837754
25MP0010352_gastrointestinal_tract_polyps1.84761092
26MP0000383_abnormal_hair_follicle1.84033324
27MP0004087_abnormal_muscle_fiber1.79114878
28MP0004510_myositis1.73563910
29MP0003091_abnormal_cell_migration1.71864052
30MP0005275_abnormal_skin_tensile1.70800384
31MP0004272_abnormal_basement_membrane1.69680331
32MP0008775_abnormal_heart_ventricle1.57872287
33MP0005501_abnormal_skin_physiology1.56762972
34MP0003191_abnormal_cellular_cholesterol1.50335006
35MP0005451_abnormal_body_composition1.47780383
36MP0005330_cardiomyopathy1.47415318
37MP0006054_spinal_hemorrhage1.45805613
38MP0009278_abnormal_bone_marrow1.44516199
39MP0002009_preneoplasia1.43894795
40MP0005623_abnormal_meninges_morphology1.43436424
41MP0001879_abnormal_lymphatic_vessel1.42122173
42MP0004036_abnormal_muscle_relaxation1.40405669
43MP0002396_abnormal_hematopoietic_system1.38859421
44MP0004808_abnormal_hematopoietic_stem1.35740643
45MP0001958_emphysema1.34254088
46MP0002006_tumorigenesis1.31294297
47MP0005023_abnormal_wound_healing1.29981019
48MP0004947_skin_inflammation1.26663652
49MP0004215_abnormal_myocardial_fiber1.25876325
50MP0004130_abnormal_muscle_cell1.25629543
51MP0000920_abnormal_myelination1.24613772
52MP0003453_abnormal_keratinocyte_physiol1.23408484
53MP0000465_gastrointestinal_hemorrhage1.22172889
54MP0002098_abnormal_vibrissa_morphology1.21679923
55MP0002972_abnormal_cardiac_muscle1.21608545
56MP0010307_abnormal_tumor_latency1.21360670
57MP0000767_abnormal_smooth_muscle1.17938889
58MP0002925_abnormal_cardiovascular_devel1.16547927
59MP0004484_altered_response_of1.14376122
60MP0000749_muscle_degeneration1.13182688
61MP0005167_abnormal_blood-brain_barrier1.13128617
62MP0005385_cardiovascular_system_phenoty1.12557443
63MP0001544_abnormal_cardiovascular_syste1.12557443
64MP0003656_abnormal_erythrocyte_physiolo1.12179851
65MP0000747_muscle_weakness1.12003703
66MP0002128_abnormal_blood_circulation1.10185242
67MP0000003_abnormal_adipose_tissue1.09267177
68MP0005058_abnormal_lysosome_morphology1.09004825
69MP0001851_eye_inflammation1.07946645
70MP0004782_abnormal_surfactant_physiolog1.07835250
71MP0002060_abnormal_skin_morphology1.07770387
72MP0000467_abnormal_esophagus_morphology1.04810805
73MP0003567_abnormal_fetal_cardiomyocyte1.04662922
74MP0000762_abnormal_tongue_morphology1.04473946
75MP0005164_abnormal_response_to1.03602246
76MP0003279_aneurysm1.01676606
77MP0000266_abnormal_heart_morphology1.00749936
78MP0010771_integument_phenotype1.00604093
79MP0004233_abnormal_muscle_weight0.99658825
80MP0005666_abnormal_adipose_tissue0.99436226
81MP0000750_abnormal_muscle_regeneration0.99015324
82MP0000627_abnormal_mammary_gland0.98703306
83MP0006138_congestive_heart_failure0.95220997
84MP0000427_abnormal_hair_cycle0.95153718
85MP0000343_altered_response_to0.92958097
86MP0003436_decreased_susceptibility_to0.92865035
87MP0000537_abnormal_urethra_morphology0.92722074
88MP0005464_abnormal_platelet_physiology0.92223815
89MP0000013_abnormal_adipose_tissue0.91968865
90MP0008260_abnormal_autophagy0.91891439
91MP0002837_dystrophic_cardiac_calcinosis0.91490095
92MP0004264_abnormal_extraembryonic_tissu0.91436399
93MP0002106_abnormal_muscle_physiology0.90606100
94MP0005621_abnormal_cell_physiology0.89492305
95MP0000377_abnormal_hair_follicle0.89318253
96MP0001784_abnormal_fluid_regulation0.87405559
97MP0001299_abnormal_eye_distance/0.86343873
98MP0001614_abnormal_blood_vessel0.85749719
99MP0001243_abnormal_dermal_layer0.85233796
100MP0004147_increased_porphyrin_level0.84886863
101MP0010155_abnormal_intestine_physiology0.84831160
102MP0002998_abnormal_bone_remodeling0.84725744
103MP0005375_adipose_tissue_phenotype0.83432456
104MP0001191_abnormal_skin_condition0.82934499
105MP0002419_abnormal_innate_immunity0.82755460
106MP0001849_ear_inflammation0.82303665
107MP0001915_intracranial_hemorrhage0.82056127
108MP0005620_abnormal_muscle_contractility0.81948901
109MP0003221_abnormal_cardiomyocyte_apopto0.81198017
110MP0003984_embryonic_growth_retardation0.80644391
111MP0002086_abnormal_extraembryonic_tissu0.80575137
112MP0002088_abnormal_embryonic_growth/wei0.80328415
113MP0002332_abnormal_exercise_endurance0.80149019
114MP0009384_cardiac_valve_regurgitation0.79828724
115MP0002896_abnormal_bone_mineralization0.79358183
116MP0005503_abnormal_tendon_morphology0.79352016
117MP0000759_abnormal_skeletal_muscle0.79167572
118MP0009931_abnormal_skin_appearance0.78071555
119MP0001533_abnormal_skeleton_physiology0.76966655
120MP0003690_abnormal_glial_cell0.76336509
121MP0001216_abnormal_epidermal_layer0.76188785
122MP0003448_altered_tumor_morphology0.74075799
123MP0005397_hematopoietic_system_phenotyp0.73417695
124MP0001545_abnormal_hematopoietic_system0.73417695
125MP0002133_abnormal_respiratory_system0.73308778
126MP0005388_respiratory_system_phenotype0.73308778
127MP0009780_abnormal_chondrocyte_physiolo0.73055625
128MP0002796_impaired_skin_barrier0.73018875
129MP0008004_abnormal_stomach_pH0.71514203
130MP0002168_other_aberrant_phenotype0.70811513
131MP0005248_abnormal_Harderian_gland0.70040142
132MP0002108_abnormal_muscle_morphology0.66465377
133MP0000428_abnormal_craniofacial_morphol0.66161850
134MP0003868_abnormal_feces_composition0.63405897
135MP0005380_embryogenesis_phenotype0.62420383
136MP0001672_abnormal_embryogenesis/_devel0.62420383
137MP0009115_abnormal_fat_cell0.61799858
138MP0009053_abnormal_anal_canal0.59739399
139MP0002971_abnormal_brown_adipose0.59702031

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.46912151
2Abnormality of nail color (HP:0100643)3.45805074
3Hyporeflexia of lower limbs (HP:0002600)3.38392803
4Right ventricular cardiomyopathy (HP:0011663)3.30822252
5Increased connective tissue (HP:0009025)3.18105719
6Arterial tortuosity (HP:0005116)3.10872353
7Onycholysis (HP:0001806)3.08429706
8Osteolytic defects of the hand bones (HP:0009699)3.03906662
9Osteolytic defects of the phalanges of the hand (HP:0009771)3.03906662
10Alopecia of scalp (HP:0002293)3.01987483
11Ankyloglossia (HP:0010296)3.01140114
12Sudden death (HP:0001699)2.94807931
13Volvulus (HP:0002580)2.91538785
14Cerebral aneurysm (HP:0004944)2.91130413
15Broad metatarsal (HP:0001783)2.89150458
16Plantar hyperkeratosis (HP:0007556)2.86236687
17Macroorchidism (HP:0000053)2.83419416
18Vascular tortuosity (HP:0004948)2.77372963
19Overgrowth (HP:0001548)2.69569071
20Muscle fiber splitting (HP:0003555)2.67859147
21Hypoplastic ischia (HP:0003175)2.66187365
22Absent frontal sinuses (HP:0002688)2.65495299
23Ventricular tachycardia (HP:0004756)2.63586556
24Hematochezia (HP:0002573)2.60576928
25Subaortic stenosis (HP:0001682)2.49793771
26Abnormality of the left ventricular outflow tract (HP:0011103)2.49793771
27Shallow orbits (HP:0000586)2.49399255
28Palmoplantar hyperkeratosis (HP:0000972)2.46846476
29Subacute progressive viral hepatitis (HP:0006572)2.45726675
30Ulnar bowing (HP:0003031)2.45635533
31Scapular winging (HP:0003691)2.42861687
32Atrial fibrillation (HP:0005110)2.42277125
33Persistence of primary teeth (HP:0006335)2.40075925
34Palmar hyperkeratosis (HP:0010765)2.36824698
35Fragile skin (HP:0001030)2.36329469
36Abnormality of the fingertips (HP:0001211)2.35527486
37Difficulty running (HP:0009046)2.34656072
38Premature rupture of membranes (HP:0001788)2.34486146
39Aortic aneurysm (HP:0004942)2.31704662
40Syringomyelia (HP:0003396)2.31515819
41Spinal cord lesions (HP:0100561)2.31515819
42Abnormality of the ischium (HP:0003174)2.31309121
43Curly hair (HP:0002212)2.28006746
44Thick nail (HP:0001805)2.26780244
45Short nail (HP:0001799)2.24337402
46Distal lower limb amyotrophy (HP:0008944)2.24231451
47Lip pit (HP:0100267)2.23391284
48Aplasia cutis congenita (HP:0001057)2.22266502
49Narrow palate (HP:0000189)2.20486885
50Vertebral arch anomaly (HP:0008438)2.18858446
51Aneurysm (HP:0002617)2.17077706
52Deep philtrum (HP:0002002)2.16403974
53Exercise-induced muscle cramps (HP:0003710)2.16059149
54Primary atrial arrhythmia (HP:0001692)2.15468720
55Periodontitis (HP:0000704)2.15331938
56Ankle contracture (HP:0006466)2.12396543
57Mitral valve prolapse (HP:0001634)2.11871686
58Increased density of long bones (HP:0006392)2.09424934
59Cubitus valgus (HP:0002967)2.07359173
60Increased mean platelet volume (HP:0011877)2.06214317
61Termporal pattern (HP:0011008)2.05420014
62Insidious onset (HP:0003587)2.05420014
63Advanced eruption of teeth (HP:0006288)2.03657121
64Hypoplasia of dental enamel (HP:0006297)2.03274941
65Exostoses (HP:0100777)2.01634045
66Ridged nail (HP:0001807)1.99333527
67Milia (HP:0001056)1.98079011
68Lipoatrophy (HP:0100578)1.97997408
69Abnormal platelet volume (HP:0011876)1.97921847
70Fragile nails (HP:0001808)1.97584187
71Supraventricular arrhythmia (HP:0005115)1.96193719
72Aortic dissection (HP:0002647)1.95050378
73Abnormality of the calf musculature (HP:0001430)1.94979096
74Spondylolisthesis (HP:0003302)1.94245089
75Nail dystrophy (HP:0008404)1.94184752
76Flat acetabular roof (HP:0003180)1.93415333
77Difficulty climbing stairs (HP:0003551)1.92701917
78Calf muscle hypertrophy (HP:0008981)1.92316974
79Supraventricular tachycardia (HP:0004755)1.92179288
80Thyroid carcinoma (HP:0002890)1.91890195
81Disproportionate tall stature (HP:0001519)1.91562149
82EMG: myopathic abnormalities (HP:0003458)1.91513083
83Neonatal hypoglycemia (HP:0001998)1.90490141
84Long eyelashes (HP:0000527)1.90100780
85Atrophic scars (HP:0001075)1.89943611
86Eczematoid dermatitis (HP:0000976)1.88938531
87Lower limb amyotrophy (HP:0007210)1.86487861
88Rectal prolapse (HP:0002035)1.85851890
89Abnormality of the nasal septum (HP:0000419)1.85578108
90Interstitial pulmonary disease (HP:0006530)1.85372815
91Coarse hair (HP:0002208)1.83713193
92Dysmetric saccades (HP:0000641)1.83202333
93Autoamputation (HP:0001218)1.83129235
94Protrusio acetabuli (HP:0003179)1.82543063
95Hyperkalemia (HP:0002153)1.81941550
96Abnormality of the frontal sinuses (HP:0002687)1.81551179
97Bundle branch block (HP:0011710)1.80669084
98Cellulitis (HP:0100658)1.77764527
99Cystic hygroma (HP:0000476)1.77555021
100Heterotopia (HP:0002282)1.77278135
101Urethral obstruction (HP:0000796)1.77141443
102Mildly elevated creatine phosphokinase (HP:0008180)1.77093884
103Spontaneous hematomas (HP:0007420)1.77071442
104Type 1 muscle fiber predominance (HP:0003803)1.77040878
105Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76968198
106Natal tooth (HP:0000695)1.76815427
107Increased variability in muscle fiber diameter (HP:0003557)1.75775923
108Blepharitis (HP:0000498)1.74508029
109Broad face (HP:0000283)1.73683508
110Muscle hypertrophy of the lower extremities (HP:0008968)1.73315706
111Hypoplastic labia majora (HP:0000059)1.71908987
112Abnormality of the salivary glands (HP:0010286)1.71304752
113Acute myeloid leukemia (HP:0004808)1.70179279
114Low anterior hairline (HP:0000294)1.69791314
115Frequent falls (HP:0002359)1.69438471
116Abnormality of the distal phalanges of the toes (HP:0010182)1.67972502
117Thoracolumbar scoliosis (HP:0002944)1.67090249
118Micronodular cirrhosis (HP:0001413)1.66784051
119Abnormality of skeletal muscle fiber size (HP:0012084)1.66258358
120Sparse scalp hair (HP:0002209)1.65479466
121Lymphangioma (HP:0100764)1.64718178
122Abnormal foot bone ossification (HP:0010675)1.64128566
123Myocardial infarction (HP:0001658)1.63773806
124Limited elbow extension (HP:0001377)1.63752791
125Deviation of the thumb (HP:0009603)1.63228119
126Distal lower limb muscle weakness (HP:0009053)1.62524050
127Syncope (HP:0001279)1.62499467
128Menstrual irregularities (HP:0000858)1.60273626
129Dilatation of the ascending aorta (HP:0005111)1.60185562
130Bladder neoplasm (HP:0009725)1.59520630
131Bladder carcinoma (HP:0002862)1.59520630
132Dilated cardiomyopathy (HP:0001644)1.59324873
133Abnormality of the peritoneum (HP:0002585)1.59314611
134Germ cell neoplasia (HP:0100728)1.58940481
135Abnormality of the distal phalanx of the thumb (HP:0009617)1.58908568
136Transitional cell carcinoma of the bladder (HP:0006740)1.58787387
137Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57582856
138Missing ribs (HP:0000921)1.57532990
139Cervical subluxation (HP:0003308)1.57379798
140Recurrent abscess formation (HP:0002722)1.56676781
141Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.55144234
142Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54591626
143Abnormality of the labia majora (HP:0012881)1.54187137
144Centrally nucleated skeletal muscle fibers (HP:0003687)1.54149815
145Increased IgE level (HP:0003212)1.53962213
146Relative macrocephaly (HP:0004482)1.53849704
147Abnormal blistering of the skin (HP:0008066)1.53825255
148Hypotrichosis (HP:0001006)1.53667859
149Distal upper limb amyotrophy (HP:0007149)1.53625642
150Upper limb amyotrophy (HP:0009129)1.53625642
151Hypoplasia of the iris (HP:0007676)1.53179225
152Asymmetry of the thorax (HP:0001555)1.53034933
153Peritonitis (HP:0002586)1.52949007
154Recurrent bacterial skin infections (HP:0005406)1.52576973
155Sparse lateral eyebrow (HP:0005338)1.52383155
156Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.52353223
157Short 4th metacarpal (HP:0010044)1.50892772
158Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.50892772
159Abnormality of oral frenula (HP:0000190)1.50310515
160Wormian bones (HP:0002645)1.50096005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.57390101
2DMPK3.43565134
3CDK122.66981636
4EPHB12.58246849
5PKN22.49606319
6RIPK12.27099913
7EPHA22.24565549
8TRIB32.21902831
9TRPM72.20221419
10NUAK12.13937321
11LATS12.12941909
12AKT31.99536172
13LATS21.95146258
14PIK3CA1.94809051
15CAMK1D1.89375421
16STK38L1.82600702
17CAMK1G1.80856519
18PTK61.80466022
19STK391.77148223
20MET1.71363020
21MST1R1.61297008
22FGFR21.59273978
23WNK11.55681399
24STK101.49031333
25STK31.42243592
26PRPF4B1.41803999
27MAP3K61.34368633
28TIE11.29641460
29EEF2K1.29236077
30BMX1.27702300
31FGFR31.23512528
32MAP3K71.22702614
33CDK61.22148277
34NEK91.21543517
35JAK11.16259020
36PDGFRA1.15148269
37ITK1.13520260
38LRRK21.11141560
39IRAK31.10989191
40BMPR21.10979177
41PNCK1.05924382
42YES11.04523631
43TGFBR21.02916829
44SGK21.02538534
45TAOK31.01064008
46KSR21.01042138
47SCYL21.00689803
48ERBB31.00329000
49STK380.96369288
50MTOR0.95876329
51FRK0.94207782
52OBSCN0.93587180
53ICK0.92033012
54STK40.89915793
55PRKD10.89209393
56ALK0.87919981
57SIK10.86796029
58RET0.86116650
59* PDGFRB0.85531316
60RPS6KB20.85258827
61BRSK20.83903781
62TEC0.83204979
63MAP4K10.82784181
64PBK0.82214704
65MAP2K30.80832669
66KSR10.79143621
67PTK20.78489536
68MAP3K10.76938272
69PTK2B0.75627972
70PAK20.75048181
71PDPK10.74120137
72MARK30.73226289
73HCK0.73161395
74WNK40.72604809
75EIF2AK30.72154722
76MAP3K20.71751485
77NEK60.70726914
78PRKCQ0.70344173
79PRKCH0.70229323
80LMTK20.69824881
81DDR20.69619221
82PIK3CG0.68232317
83SGK30.68214941
84BRD40.67725800
85CLK10.66473947
86KIT0.66354129
87FGFR10.65577899
88NLK0.65365868
89ROCK20.64265728
90PDK10.64201458
91JAK20.63286142
92NEK20.62076939
93MAP3K100.61621865
94PAK40.60967954
95MAP3K130.59669587
96MARK20.58860430
97EPHB20.58821025
98MAP3K120.58662433
99STK240.57520814
100PRKAA20.57505631
101FGR0.57069252
102MAP3K140.57068086
103SMG10.56324502
104FER0.55873157
105ILK0.55110892
106JAK30.54171563
107EGFR0.54041990
108OXSR10.53580853
109CSNK1A1L0.51049974
110ERBB40.50108708
111MAP3K30.49495427
112MOS0.49453156
113MAP3K80.49385886
114MELK0.49234459
115RPS6KB10.48807734
116FGFR40.48770167
117GSK3A0.47874784
118MST40.47650867
119CDK90.46730291
120SGK2230.46328037
121SGK4940.46328037
122TAOK10.46273740
123TYK20.45758483
124RAF10.45680920
125ROCK10.45469052
126CSNK1D0.44892105
127SGK10.44368650
128ABL10.44219175
129PAK30.43652335
130ZAP700.43609987
131MAPK100.41586425
132* FYN0.40108011
133CSF1R0.39358520
134CAMK2D0.39089849
135CDC70.38910069
136IRAK40.38751339
137MAP3K90.38074816
138ACVR1B0.36662951
139MYLK0.36299310
140IRAK20.36251800
141TGFBR10.33994028
142CDC42BPA0.31788917

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.09324135
2Focal adhesion_Homo sapiens_hsa045102.00145259
3Dilated cardiomyopathy_Homo sapiens_hsa054141.94148299
4Leukocyte transendothelial migration_Homo sapiens_hsa046701.90238394
5Thyroid cancer_Homo sapiens_hsa052161.89653713
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.83632901
7Adherens junction_Homo sapiens_hsa045201.82282608
8Proteoglycans in cancer_Homo sapiens_hsa052051.73299204
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.73170198
10Platelet activation_Homo sapiens_hsa046111.69312270
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67332701
12Small cell lung cancer_Homo sapiens_hsa052221.67237195
13Osteoclast differentiation_Homo sapiens_hsa043801.59298145
14Toxoplasmosis_Homo sapiens_hsa051451.57823355
15Circadian rhythm_Homo sapiens_hsa047101.53600716
16Leishmaniasis_Homo sapiens_hsa051401.53306921
17Chronic myeloid leukemia_Homo sapiens_hsa052201.51950505
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51287952
19Lysine degradation_Homo sapiens_hsa003101.50176491
20Viral myocarditis_Homo sapiens_hsa054161.49633194
21Dorso-ventral axis formation_Homo sapiens_hsa043201.49417390
22Amoebiasis_Homo sapiens_hsa051461.43665180
23Regulation of actin cytoskeleton_Homo sapiens_hsa048101.43204504
24Renal cell carcinoma_Homo sapiens_hsa052111.33579925
25MicroRNAs in cancer_Homo sapiens_hsa052061.29139850
26B cell receptor signaling pathway_Homo sapiens_hsa046621.26862912
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26091056
28Prolactin signaling pathway_Homo sapiens_hsa049171.25481320
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25407871
30Salmonella infection_Homo sapiens_hsa051321.19185423
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16134779
32Insulin resistance_Homo sapiens_hsa049311.16113521
33Pancreatic cancer_Homo sapiens_hsa052121.13606338
34Malaria_Homo sapiens_hsa051441.11834598
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11744487
36Bladder cancer_Homo sapiens_hsa052191.10575286
37Tight junction_Homo sapiens_hsa045301.10128318
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09967899
39Insulin signaling pathway_Homo sapiens_hsa049101.05158042
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03944822
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02142504
42Colorectal cancer_Homo sapiens_hsa052101.01764698
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.01685681
44Non-small cell lung cancer_Homo sapiens_hsa052231.01683956
45Type II diabetes mellitus_Homo sapiens_hsa049300.97073689
46TNF signaling pathway_Homo sapiens_hsa046680.95933352
47mTOR signaling pathway_Homo sapiens_hsa041500.95561723
48Endocytosis_Homo sapiens_hsa041440.95040788
49Rap1 signaling pathway_Homo sapiens_hsa040150.94479157
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94180339
51VEGF signaling pathway_Homo sapiens_hsa043700.93707976
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93107651
53Prostate cancer_Homo sapiens_hsa052150.92798071
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92771355
55T cell receptor signaling pathway_Homo sapiens_hsa046600.92744277
56Chemokine signaling pathway_Homo sapiens_hsa040620.91051570
57Acute myeloid leukemia_Homo sapiens_hsa052210.89474510
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89093893
59Glioma_Homo sapiens_hsa052140.88663454
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.87488235
61Pertussis_Homo sapiens_hsa051330.86424480
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86196701
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85711132
64Tuberculosis_Homo sapiens_hsa051520.85157217
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84391840
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.84036111
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.83284837
68Endometrial cancer_Homo sapiens_hsa052130.82433267
69Hematopoietic cell lineage_Homo sapiens_hsa046400.82168936
70Fatty acid biosynthesis_Homo sapiens_hsa000610.81450192
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81141750
72ErbB signaling pathway_Homo sapiens_hsa040120.80880257
73Staphylococcus aureus infection_Homo sapiens_hsa051500.80683254
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80543799
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79845739
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79673108
77HIF-1 signaling pathway_Homo sapiens_hsa040660.79332100
78Melanoma_Homo sapiens_hsa052180.79078987
79PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78994392
80Shigellosis_Homo sapiens_hsa051310.77944112
81Long-term potentiation_Homo sapiens_hsa047200.77445364
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77171130
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.76498250
84Pathways in cancer_Homo sapiens_hsa052000.76328728
85Notch signaling pathway_Homo sapiens_hsa043300.74050930
86Pancreatic secretion_Homo sapiens_hsa049720.73221574
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.72634866
88Inositol phosphate metabolism_Homo sapiens_hsa005620.71960617
89Measles_Homo sapiens_hsa051620.70777178
90Hepatitis B_Homo sapiens_hsa051610.70708437
91Axon guidance_Homo sapiens_hsa043600.70603958
92Apoptosis_Homo sapiens_hsa042100.70543654
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69689171
94Estrogen signaling pathway_Homo sapiens_hsa049150.69624649
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.69569506
96MAPK signaling pathway_Homo sapiens_hsa040100.68948213
97Sphingolipid metabolism_Homo sapiens_hsa006000.68032982
98Viral carcinogenesis_Homo sapiens_hsa052030.67559075
99TGF-beta signaling pathway_Homo sapiens_hsa043500.67454069
100Nitrogen metabolism_Homo sapiens_hsa009100.67338690
101cAMP signaling pathway_Homo sapiens_hsa040240.65817726
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65502035
103Hippo signaling pathway_Homo sapiens_hsa043900.64437524
104Influenza A_Homo sapiens_hsa051640.62848434
105AMPK signaling pathway_Homo sapiens_hsa041520.62152588
106Renin secretion_Homo sapiens_hsa049240.62091572
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61993157
108Gastric acid secretion_Homo sapiens_hsa049710.61662016
109Choline metabolism in cancer_Homo sapiens_hsa052310.61201986
110Oxytocin signaling pathway_Homo sapiens_hsa049210.60739674
111Ras signaling pathway_Homo sapiens_hsa040140.59780823
112Hepatitis C_Homo sapiens_hsa051600.59701906
113FoxO signaling pathway_Homo sapiens_hsa040680.59530134
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58533640
115Glucagon signaling pathway_Homo sapiens_hsa049220.58525121
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57041887
117p53 signaling pathway_Homo sapiens_hsa041150.57036070
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.56815686
119HTLV-I infection_Homo sapiens_hsa051660.55207226
120Protein digestion and absorption_Homo sapiens_hsa049740.54496295
121GnRH signaling pathway_Homo sapiens_hsa049120.52646471
122Antigen processing and presentation_Homo sapiens_hsa046120.51717894
123Lysosome_Homo sapiens_hsa041420.50850222

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