SLITRK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.17192840
2cellular response to vitamin D (GO:0071305)7.00462445
3desmosome organization (GO:0002934)6.54968029
4regulation of sister chromatid cohesion (GO:0007063)6.14985107
5ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043166.09011133
6COPI coating of Golgi vesicle (GO:0048205)5.56407375
7Golgi transport vesicle coating (GO:0048200)5.56407375
8bundle of His cell to Purkinje myocyte communication (GO:0086069)5.24634380
9regulation of cardioblast proliferation (GO:0003264)5.08705696
10regulation of secondary heart field cardioblast proliferation (GO:0003266)5.08705696
11dorsal/ventral axis specification (GO:0009950)4.95539477
12dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.83957614
13cellular response to vitamin (GO:0071295)4.79543642
14axonemal dynein complex assembly (GO:0070286)4.73793766
15hair cell differentiation (GO:0035315)4.72485368
16negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.57554698
17gland morphogenesis (GO:0022612)4.56957923
18auditory receptor cell differentiation (GO:0042491)4.52457155
19endocrine pancreas development (GO:0031018)4.47970297
20mesenchymal-epithelial cell signaling (GO:0060638)4.43631979
21regulation of somitogenesis (GO:0014807)4.42236893
22intestinal epithelial cell development (GO:0060576)4.39542905
23mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.29929482
24keratinocyte development (GO:0003334)4.28234959
25type B pancreatic cell development (GO:0003323)4.25794617
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.21832503
27cilium or flagellum-dependent cell motility (GO:0001539)4.18489583
28establishment of planar polarity (GO:0001736)4.16962479
29establishment of tissue polarity (GO:0007164)4.16962479
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.10118336
31negative regulation of keratinocyte proliferation (GO:0010839)4.06799455
32heparin biosynthetic process (GO:0030210)4.06353800
33heparin metabolic process (GO:0030202)4.06353800
34glandular epithelial cell development (GO:0002068)4.03987739
35cilium movement (GO:0003341)3.95955843
36glandular epithelial cell differentiation (GO:0002067)3.89616009
37genitalia morphogenesis (GO:0035112)3.88509281
38positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.86922369
39face development (GO:0060324)3.82446696
40peptide hormone processing (GO:0016486)3.82315594
41mesenchymal cell differentiation (GO:0048762)3.80617525
42protein maturation by protein folding (GO:0022417)3.76098025
43positive regulation of nitric-oxide synthase activity (GO:0051000)3.74941432
44* innervation (GO:0060384)3.72534848
45protein retention in ER lumen (GO:0006621)3.70109655
46regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.69482594
47nephron tubule formation (GO:0072079)3.69377042
48regulation of type B pancreatic cell apoptotic process (GO:2000674)3.66204265
49cardiac right ventricle morphogenesis (GO:0003215)3.64655399
50exocrine pancreas development (GO:0031017)3.62828666
51cellular response to prostaglandin stimulus (GO:0071379)3.61175490
52negative regulation of cell fate specification (GO:0009996)3.57634986
53L-serine transport (GO:0015825)3.57018362
54regulation of cardioblast differentiation (GO:0051890)3.54685795
55inner ear receptor cell development (GO:0060119)3.53673881
56insulin secretion (GO:0030073)3.53600872
57apical protein localization (GO:0045176)3.46848556
58pancreas development (GO:0031016)3.43804143
59attachment of spindle microtubules to kinetochore (GO:0008608)3.42606959
60epithelial cilium movement (GO:0003351)3.41570813
61inner ear receptor cell differentiation (GO:0060113)3.41147759
62lung lobe morphogenesis (GO:0060463)3.35722478
63negative regulation of axon guidance (GO:1902668)3.34177950
64asymmetric protein localization (GO:0008105)3.31313610
65ectodermal placode formation (GO:0060788)3.28705218
66retinal ganglion cell axon guidance (GO:0031290)3.27549205
67epithelial cell differentiation involved in prostate gland development (GO:0060742)3.27542193
68negative chemotaxis (GO:0050919)3.23828948
69regulation of cell fate specification (GO:0042659)3.22941672
70somite development (GO:0061053)3.20024525
71negative regulation of axon extension involved in axon guidance (GO:0048843)3.19037219
72retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.18573776
73fat-soluble vitamin catabolic process (GO:0042363)3.18252163
74vitamin catabolic process (GO:0009111)3.18252163
75regulation of phospholipid biosynthetic process (GO:0071071)3.17175007
76columnar/cuboidal epithelial cell development (GO:0002066)3.15254435
77glial cell proliferation (GO:0014009)3.15207015
78COPII vesicle coating (GO:0048208)3.13682470
79membrane budding (GO:0006900)3.13482136
80magnesium ion transport (GO:0015693)3.13232965
81cytoskeletal anchoring at plasma membrane (GO:0007016)3.12360709
82protein localization to cilium (GO:0061512)3.11777428
83polarized epithelial cell differentiation (GO:0030859)3.11497705
84branch elongation of an epithelium (GO:0060602)3.11393155
85detection of calcium ion (GO:0005513)3.09130822
86establishment or maintenance of monopolar cell polarity (GO:0061339)3.07031516
87establishment of monopolar cell polarity (GO:0061162)3.07031516
88regulation of insulin secretion (GO:0050796)3.06915487
89epithelial cell maturation (GO:0002070)3.06892978
90ganglion development (GO:0061548)3.05691696
91ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.05685892
92regulation of keratinocyte proliferation (GO:0010837)3.05339649
93epithelial cell fate commitment (GO:0072148)3.04942417
94establishment of apical/basal cell polarity (GO:0035089)3.04429089
95keratinocyte proliferation (GO:0043616)3.03910845
96oligodendrocyte differentiation (GO:0048709)3.02939580
97endocardial cushion morphogenesis (GO:0003203)3.02333040
98midgut development (GO:0007494)3.01712764
99layer formation in cerebral cortex (GO:0021819)3.01509187
100male meiosis (GO:0007140)3.00182975
101positive regulation of insulin secretion (GO:0032024)2.98300260
102heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.96735402
103hindbrain development (GO:0030902)2.96434283
104multicellular organismal water homeostasis (GO:0050891)2.93776020
105mesenchymal to epithelial transition (GO:0060231)2.93074594
106positive regulation of glycoprotein metabolic process (GO:1903020)2.91208011
107regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.89740829
108sequestering of metal ion (GO:0051238)2.89633350
109intraciliary transport (GO:0042073)2.89369556
110activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.88504575
111cell-substrate junction assembly (GO:0007044)2.86131070
112lung-associated mesenchyme development (GO:0060484)2.85819815
113regulation of inositol phosphate biosynthetic process (GO:0010919)2.85636882
114regulation of axon guidance (GO:1902667)2.85465475
115regulation of water loss via skin (GO:0033561)2.84105602
116negative regulation of hormone biosynthetic process (GO:0032353)2.81901866
117negative regulation of hormone metabolic process (GO:0032351)2.81901866
118establishment of skin barrier (GO:0061436)2.81248764
119ER overload response (GO:0006983)2.81040985
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80245274
121epidermis development (GO:0008544)2.79848170
122positive regulation of glycoprotein biosynthetic process (GO:0010560)2.79507034
123pathway-restricted SMAD protein phosphorylation (GO:0060389)2.79102009
124regulation of peptide hormone secretion (GO:0090276)2.78561650
125calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.78535251
126serine transport (GO:0032329)2.78355176
127facial nerve structural organization (GO:0021612)2.78067873
128proximal/distal pattern formation (GO:0009954)2.76774156
129lateral sprouting from an epithelium (GO:0060601)2.76271977
130positive regulation of embryonic development (GO:0040019)2.76052200
131gastrulation with mouth forming second (GO:0001702)2.75748894
132nitric oxide mediated signal transduction (GO:0007263)2.75518087
133homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.74329970
134positive regulation of alcohol biosynthetic process (GO:1902932)2.73647267
135negative regulation of cartilage development (GO:0061037)2.73460208
136pyrimidine-containing compound transmembrane transport (GO:0072531)2.73071441
137regulation of peptide secretion (GO:0002791)2.72569108
138surfactant homeostasis (GO:0043129)2.72011297
139regulation of axon extension involved in axon guidance (GO:0048841)2.69886040
140nucleotide transmembrane transport (GO:1901679)2.69322332
141mechanoreceptor differentiation (GO:0042490)2.68985396
142positive regulation of nuclease activity (GO:0032075)2.68501557
143negative regulation of oligodendrocyte differentiation (GO:0048715)2.68100642
144embryonic foregut morphogenesis (GO:0048617)2.66399673
145ectoderm development (GO:0007398)2.65455490
146axis elongation (GO:0003401)2.65450547
147positive regulation of organelle assembly (GO:1902117)2.63927360
148peptide hormone secretion (GO:0030072)2.63865691
149growth hormone secretion (GO:0030252)2.62690396
150NLS-bearing protein import into nucleus (GO:0006607)2.61526097
151chemical homeostasis within a tissue (GO:0048875)2.61453698
152endoplasmic reticulum organization (GO:0007029)2.60817914
153oocyte development (GO:0048599)2.60117815
154axon extension involved in axon guidance (GO:0048846)2.59586483
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.59586483
156* cochlea development (GO:0090102)2.59415500
157cellular response to nutrient (GO:0031670)2.59182202
158regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.59172790
159protein kinase C signaling (GO:0070528)2.59011152
160regulation of cilium movement (GO:0003352)2.58705875
161negative regulation of catecholamine secretion (GO:0033604)2.58177894
162Sertoli cell development (GO:0060009)2.53985136
163regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.53232745
164branching involved in mammary gland duct morphogenesis (GO:0060444)2.50506575
165type B pancreatic cell proliferation (GO:0044342)2.48429166
166regulation of oligodendrocyte differentiation (GO:0048713)2.45330978
167cardiac ventricle morphogenesis (GO:0003208)2.45179747
168renal system development (GO:0072001)2.44648987
169negative regulation of T cell differentiation in thymus (GO:0033085)2.42236509
170microtubule anchoring (GO:0034453)2.41967787
171ear development (GO:0043583)2.39057072
172molting cycle (GO:0042303)2.37360669
173hair cycle (GO:0042633)2.37360669
174axonal fasciculation (GO:0007413)2.34966451
175G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.34306387
176amyloid precursor protein catabolic process (GO:0042987)2.34115343
177mammary gland development (GO:0030879)2.33891184
178cornea development in camera-type eye (GO:0061303)2.32576990
179cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.32319722
180cell-cell adhesion (GO:0098609)2.31127059
181drinking behavior (GO:0042756)2.30460198
182cell adhesion mediated by integrin (GO:0033627)2.30316723
183positive regulation of glycogen biosynthetic process (GO:0045725)2.30176821
184phosphatidylinositol 3-kinase signaling (GO:0014065)2.29957917
185water homeostasis (GO:0030104)2.27480477
186regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.25530823
187semaphorin-plexin signaling pathway (GO:0071526)2.23966714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human4.18464444
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.74214531
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.47684745
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.39338895
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.22532914
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.68955678
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.66465896
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.63868125
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.62834659
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61528310
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.53646311
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.52097159
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43054978
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40749666
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34273339
16GBX2_23144817_ChIP-Seq_PC3_Human2.33925081
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32286597
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.28618099
19TAF15_26573619_Chip-Seq_HEK293_Human2.21783732
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19920085
21EZH2_22144423_ChIP-Seq_EOC_Human2.18535831
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17967535
23PIAS1_25552417_ChIP-Seq_VCAP_Human2.16940889
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16738356
25ZNF263_19887448_ChIP-Seq_K562_Human2.05743622
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.04702326
27IGF1R_20145208_ChIP-Seq_DFB_Human2.04121581
28* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99506567
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98488286
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92820206
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92820206
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87388079
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85518062
34* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85410994
35NR3C1_23031785_ChIP-Seq_PC12_Mouse1.80371343
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80188378
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76828064
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73786244
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.70468685
40AHR_22903824_ChIP-Seq_MCF-7_Human1.69398215
41ZNF274_21170338_ChIP-Seq_K562_Hela1.67625419
42TCF4_18268006_ChIP-ChIP_LS174T_Human1.67366945
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.67209088
44GATA3_24758297_ChIP-Seq_MCF-7_Human1.65756063
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65202142
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.61546435
47ER_23166858_ChIP-Seq_MCF-7_Human1.60952553
48* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60482316
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59167713
50REST_21632747_ChIP-Seq_MESCs_Mouse1.56469693
51* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56202815
52* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53646587
53CJUN_26792858_Chip-Seq_BT549_Human1.51891278
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51237904
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.50244530
56SMAD4_21799915_ChIP-Seq_A2780_Human1.49757032
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.49410824
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.48756662
59* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48185715
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47443490
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46334970
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44957941
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42942044
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42942044
65BCAT_22108803_ChIP-Seq_LS180_Human1.42553297
66* SOX2_21211035_ChIP-Seq_LN229_Gbm1.40631327
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40195442
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39976420
69* FUS_26573619_Chip-Seq_HEK293_Human1.38354421
70STAT3_23295773_ChIP-Seq_U87_Human1.37243168
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36731052
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35548021
73AR_19668381_ChIP-Seq_PC3_Human1.34882713
74TBX3_20139965_ChIP-Seq_MESCs_Mouse1.34414702
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33508098
76TP63_23658742_ChIP-Seq_EP156T_Human1.33460540
77* P300_19829295_ChIP-Seq_ESCs_Human1.33388752
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32829093
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.32456260
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32263198
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32012175
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31881701
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31217495
84* SMAD3_21741376_ChIP-Seq_EPCs_Human1.31095500
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30958344
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30003383
87* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29086115
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28825145
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.26910569
90TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26647783
91CDX2_20551321_ChIP-Seq_CACO-2_Human1.25979888
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25894496
93DROSHA_22980978_ChIP-Seq_HELA_Human1.25376960
94TP53_18474530_ChIP-ChIP_U2OS_Human1.24259945
95SMAD3_21741376_ChIP-Seq_ESCs_Human1.23322124
96FOXA1_25552417_ChIP-Seq_VCAP_Human1.23187354
97KLF5_25053715_ChIP-Seq_YYC3_Human1.22098330
98* EWS_26573619_Chip-Seq_HEK293_Human1.21791494
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20114776
100ELF5_23300383_ChIP-Seq_T47D_Human1.19727778
101GF1B_26923725_Chip-Seq_HPCs_Mouse1.18724471
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.18437460
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17670359
104GATA4_25053715_ChIP-Seq_YYC3_Human1.17622918
105PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17618734
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17175670
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.17121726
108SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16404070
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15469690
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14660072
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14098730
112* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12990054
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.12782892
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12680566
115TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06742500
116CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06713934
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06471478
118* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06114804
119NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05919649
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04933809
121RING1B_27294783_Chip-Seq_ESCs_Mouse1.04529151
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03948707
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02650645
124CBP_20019798_ChIP-Seq_JUKART_Human1.02650645
125CLOCK_20551151_ChIP-Seq_293T_Human1.02194813
126P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01626179
127* TCF4_22108803_ChIP-Seq_LS180_Human1.01180632
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01093683
129NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01093683
130ESR1_21235772_ChIP-Seq_MCF-7_Human1.00810999
131* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99935692
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.99526109
133* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99017827
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98958295
135AR_25329375_ChIP-Seq_VCAP_Human0.98781235
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98681392
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98054314
138GATA6_25053715_ChIP-Seq_YYC3_Human0.97913408
139RNF2_27304074_Chip-Seq_NSC_Mouse0.97505327
140* SOX2_20726797_ChIP-Seq_SW620_Human0.96400566
141* TAL1_26923725_Chip-Seq_HPCs_Mouse0.95071583
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94799834
143REST_18959480_ChIP-ChIP_MESCs_Mouse0.94582212
144PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89798250
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86831129
146NANOG_18555785_Chip-Seq_ESCs_Mouse0.85811771
147* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85188785
148FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84120307
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83421687
150CDX2_22108803_ChIP-Seq_LS180_Human0.82177549
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80444148
152ELK4_26923725_Chip-Seq_MESODERM_Mouse0.80323680
153HOXB7_26014856_ChIP-Seq_BT474_Human0.79618427
154EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.78352947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.79366248
2MP0003283_abnormal_digestive_organ4.00824701
3MP0006054_spinal_hemorrhage4.00429758
4MP0005248_abnormal_Harderian_gland3.66622967
5MP0009780_abnormal_chondrocyte_physiolo3.22396490
6MP0008961_abnormal_basal_metabolism3.09738314
7MP0005220_abnormal_exocrine_pancreas2.96065957
8MP0000537_abnormal_urethra_morphology2.65695426
9MP0002693_abnormal_pancreas_physiology2.59559219
10MP0001944_abnormal_pancreas_morphology2.58880007
11MP0002877_abnormal_melanocyte_morpholog2.51090060
12MP0000566_synostosis2.49326860
13MP0003122_maternal_imprinting2.46731992
14MP0004043_abnormal_pH_regulation2.44735300
15MP0001346_abnormal_lacrimal_gland2.35870051
16MP0005275_abnormal_skin_tensile2.29730585
17MP0003879_abnormal_hair_cell2.14760866
18MP0003195_calcinosis2.12996206
19MP0003121_genomic_imprinting2.10234185
20MP0000762_abnormal_tongue_morphology2.08419052
21MP0005187_abnormal_penis_morphology2.04716773
22MP0000467_abnormal_esophagus_morphology2.03038396
23MP0002736_abnormal_nociception_after2.00091767
24MP0001502_abnormal_circadian_rhythm1.99552692
25MP0000427_abnormal_hair_cycle1.98411624
26MP0005257_abnormal_intraocular_pressure1.97292778
27MP0001485_abnormal_pinna_reflex1.94871071
28MP0002909_abnormal_adrenal_gland1.90254612
29MP0010386_abnormal_urinary_bladder1.88071328
30MP0002796_impaired_skin_barrier1.87496202
31MP0005379_endocrine/exocrine_gland_phen1.82049429
32MP0000377_abnormal_hair_follicle1.79874697
33MP0003315_abnormal_perineum_morphology1.76612332
34MP0010678_abnormal_skin_adnexa1.74656162
35MP0002938_white_spotting1.71825595
36MP0005409_darkened_coat_color1.67175860
37MP0000013_abnormal_adipose_tissue1.64635875
38MP0001849_ear_inflammation1.60594979
39MP0003890_abnormal_embryonic-extraembry1.57329364
40MP0001216_abnormal_epidermal_layer1.55778035
41MP0003878_abnormal_ear_physiology1.51142015
42MP0005377_hearing/vestibular/ear_phenot1.51142015
43MP0004782_abnormal_surfactant_physiolog1.50460587
44MP0003942_abnormal_urinary_system1.50091944
45MP0002751_abnormal_autonomic_nervous1.49316792
46MP0005394_taste/olfaction_phenotype1.49300876
47MP0005499_abnormal_olfactory_system1.49300876
48MP0000678_abnormal_parathyroid_gland1.46962014
49MP0002896_abnormal_bone_mineralization1.45292225
50MP0000631_abnormal_neuroendocrine_gland1.43975906
51MP0003941_abnormal_skin_development1.43465627
52MP0002928_abnormal_bile_duct1.37749571
53MP0009053_abnormal_anal_canal1.36585592
54MP0002078_abnormal_glucose_homeostasis1.35960094
55MP0000613_abnormal_salivary_gland1.32339886
56MP0003119_abnormal_digestive_system1.30069630
57MP0004264_abnormal_extraembryonic_tissu1.27139375
58MP0000627_abnormal_mammary_gland1.26314981
59MP0010771_integument_phenotype1.25242762
60MP0005501_abnormal_skin_physiology1.24676385
61MP0006072_abnormal_retinal_apoptosis1.24501531
62MP0001963_abnormal_hearing_physiology1.24469347
63MP0004859_abnormal_synaptic_plasticity1.22496258
64MP0005367_renal/urinary_system_phenotyp1.19435711
65MP0000516_abnormal_urinary_system1.19435711
66MP0003755_abnormal_palate_morphology1.18253131
67* MP0002184_abnormal_innervation1.18157950
68MP0000428_abnormal_craniofacial_morphol1.13554327
69* MP0000026_abnormal_inner_ear1.13009434
70MP0001270_distended_abdomen1.12626372
71MP0003566_abnormal_cell_adhesion1.11325182
72MP0000462_abnormal_digestive_system1.08728329
73MP0003136_yellow_coat_color1.08298072
74MP0004130_abnormal_muscle_cell1.07091983
75MP0000647_abnormal_sebaceous_gland1.06607413
76MP0000778_abnormal_nervous_system1.06015751
77MP0001299_abnormal_eye_distance/1.05906605
78MP0002233_abnormal_nose_morphology1.04750560
79MP0001968_abnormal_touch/_nociception1.03456591
80MP0000163_abnormal_cartilage_morphology1.02996342
81MP0008995_early_reproductive_senescence1.02031318
82MP0002837_dystrophic_cardiac_calcinosis1.01302121
83MP0002234_abnormal_pharynx_morphology1.01293347
84MP0003183_abnormal_peptide_metabolism1.01254093
85MP0003115_abnormal_respiratory_system1.00012083
86MP0003936_abnormal_reproductive_system0.99551882
87MP0002090_abnormal_vision0.97615174
88MP0003252_abnormal_bile_duct0.97160872
89MP0001177_atelectasis0.96371700
90MP0001984_abnormal_olfaction0.95828023
91MP0002116_abnormal_craniofacial_bone0.95250402
92MP0003453_abnormal_keratinocyte_physiol0.95065523
93MP0005645_abnormal_hypothalamus_physiol0.92235019
94MP0005076_abnormal_cell_differentiation0.90217055
95MP0002653_abnormal_ependyma_morphology0.89976882
96MP0005646_abnormal_pituitary_gland0.88699505
97MP0005408_hypopigmentation0.88453661
98MP0004133_heterotaxia0.87140021
99MP0000003_abnormal_adipose_tissue0.84033412
100MP0002098_abnormal_vibrissa_morphology0.83859418
101MP0005253_abnormal_eye_physiology0.82774209
102MP0003953_abnormal_hormone_level0.79682165
103MP0002249_abnormal_larynx_morphology0.78281069
104MP0005508_abnormal_skeleton_morphology0.78233362
105MP0002733_abnormal_thermal_nociception0.78162382
106MP0003123_paternal_imprinting0.76452475
107MP0001664_abnormal_digestion0.76051834
108MP0001340_abnormal_eyelid_morphology0.75887433
109MP0009703_decreased_birth_body0.75113723
110MP0002009_preneoplasia0.74817194
111MP0003935_abnormal_craniofacial_develop0.73179209
112MP0002127_abnormal_cardiovascular_syste0.72982980
113MP0003567_abnormal_fetal_cardiomyocyte0.71545712
114MP0000538_abnormal_urinary_bladder0.71426214
115MP0004272_abnormal_basement_membrane0.71040368
116MP0002177_abnormal_outer_ear0.70281672
117MP0000534_abnormal_ureter_morphology0.70272367
118MP0002282_abnormal_trachea_morphology0.70082033
119MP0000470_abnormal_stomach_morphology0.69451224
120MP0005623_abnormal_meninges_morphology0.69183035
121MP0003861_abnormal_nervous_system0.68671969
122MP0002115_abnormal_skeleton_extremities0.68472048
123MP0000579_abnormal_nail_morphology0.66939289
124MP0005167_abnormal_blood-brain_barrier0.66518109
125MP0008875_abnormal_xenobiotic_pharmacok0.66079534
126MP0000367_abnormal_coat/_hair0.65882732
127MP0002697_abnormal_eye_size0.65873037
128MP0002638_abnormal_pupillary_reflex0.65472110
129MP0009384_cardiac_valve_regurgitation0.65332552
130MP0009672_abnormal_birth_weight0.65280420
131MP0009931_abnormal_skin_appearance0.64551438
132MP0002089_abnormal_postnatal_growth/wei0.64518012
133MP0004270_analgesia0.63841042
134MP0008789_abnormal_olfactory_epithelium0.63420418
135MP0004134_abnormal_chest_morphology0.62958814
136MP0002932_abnormal_joint_morphology0.62748982
137MP0005448_abnormal_energy_balance0.62113099
138MP0000383_abnormal_hair_follicle0.61779478
139MP0000955_abnormal_spinal_cord0.61723251
140MP0004381_abnormal_hair_follicle0.61383338
141MP0010030_abnormal_orbit_morphology0.61236688
142MP0002060_abnormal_skin_morphology0.61195659
143MP0002163_abnormal_gland_morphology0.60631113
144MP0003937_abnormal_limbs/digits/tail_de0.59949578
145MP0008260_abnormal_autophagy0.59790257
146MP0004019_abnormal_vitamin_homeostasis0.59770431
147MP0003880_abnormal_central_pattern0.59140981
148MP0004084_abnormal_cardiac_muscle0.58146253
149MP0003943_abnormal_hepatobiliary_system0.57942781
150MP0000049_abnormal_middle_ear0.57689866

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)5.76011200
2Milia (HP:0001056)5.36478890
3Abnormality of nail color (HP:0100643)5.29059827
4Fragile nails (HP:0001808)5.18492401
5Concave nail (HP:0001598)5.04365027
6Hyperinsulinemic hypoglycemia (HP:0000825)4.99083723
7Atrophic scars (HP:0001075)4.94324804
8Hypoglycemic seizures (HP:0002173)4.85870787
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.45527473
10Plantar hyperkeratosis (HP:0007556)4.38939372
11Volvulus (HP:0002580)4.32331994
12Symptomatic seizures (HP:0011145)4.14342335
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.13844260
14Right ventricular cardiomyopathy (HP:0011663)4.12715559
15Insulin-resistant diabetes mellitus (HP:0000831)3.86110200
16Sparse lateral eyebrow (HP:0005338)3.85531251
17Germ cell neoplasia (HP:0100728)3.79587725
18Subacute progressive viral hepatitis (HP:0006572)3.77979716
19Hypoglycemic coma (HP:0001325)3.67443031
20Humeroradial synostosis (HP:0003041)3.48532144
21Synostosis involving the elbow (HP:0003938)3.48532144
22Abnormal respiratory motile cilium physiology (HP:0012261)3.41514859
23Abnormal respiratory epithelium morphology (HP:0012253)3.37475369
24Abnormal respiratory motile cilium morphology (HP:0005938)3.37475369
25Increased nuchal translucency (HP:0010880)3.36772654
26Rhinitis (HP:0012384)3.35478698
27Alopecia of scalp (HP:0002293)3.35424325
28Chronic bronchitis (HP:0004469)3.33876604
29Hyperglycemia (HP:0003074)3.28276545
30Abnormal umbilical cord blood vessels (HP:0011403)3.27411533
31Single umbilical artery (HP:0001195)3.27411533
32Abnormality of the fetal cardiovascular system (HP:0010948)3.27411533
33Termporal pattern (HP:0011008)3.22057213
34Insidious onset (HP:0003587)3.22057213
35Pancreatic islet-cell hyperplasia (HP:0004510)3.10915917
36Hypoplasia of dental enamel (HP:0006297)3.07330035
37Unilateral renal agenesis (HP:0000122)3.03745037
38Occipital encephalocele (HP:0002085)3.03027330
39Abnormal ciliary motility (HP:0012262)3.01976986
40Abnormal pancreas size (HP:0012094)3.01824337
41Abnormality of endocrine pancreas physiology (HP:0012093)3.01292219
42Abnormality of the pancreatic islet cells (HP:0006476)3.01292219
43Abnormality of the proximal phalanges of the hand (HP:0009834)2.89053047
44Flat capital femoral epiphysis (HP:0003370)2.88936494
45Congenital sensorineural hearing impairment (HP:0008527)2.88054336
46Abnormality of the dental root (HP:0006486)2.79708075
47Taurodontia (HP:0000679)2.79708075
48Abnormality of permanent molar morphology (HP:0011071)2.79708075
49Nail dystrophy (HP:0008404)2.77130886
50Mixed hearing impairment (HP:0000410)2.70811494
51Palmar hyperkeratosis (HP:0010765)2.67062020
52Palmoplantar hyperkeratosis (HP:0000972)2.63368985
53Pterygium (HP:0001059)2.62791523
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.60986240
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.57621485
56Absent/shortened dynein arms (HP:0200106)2.57621485
57Hypoplastic ischia (HP:0003175)2.55810427
58Abnormality of molar (HP:0011077)2.54857028
59Abnormality of molar morphology (HP:0011070)2.54857028
60Turricephaly (HP:0000262)2.53598594
61Breast carcinoma (HP:0003002)2.52951203
62Abnormality of calcium-phosphate metabolism (HP:0100530)2.52399623
63Aqueductal stenosis (HP:0002410)2.51975317
64Epiphyseal dysplasia (HP:0002656)2.51698711
65Brachycephaly (HP:0000248)2.49461837
66Round ear (HP:0100830)2.49302120
67Ketoacidosis (HP:0001993)2.49251489
68Abnormality of the umbilical cord (HP:0010881)2.48271355
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.47551637
70Hypoplasia of the fovea (HP:0007750)2.47551637
71Absent eyelashes (HP:0000561)2.42174146
72Thick nail (HP:0001805)2.39032303
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39008388
74Abnormality of the dental pulp (HP:0006479)2.37574709
75Hepatoblastoma (HP:0002884)2.36931202
76Spastic gait (HP:0002064)2.35082508
77Abnormality of the ischium (HP:0003174)2.34393113
78Hypoplastic labia majora (HP:0000059)2.34255125
79Large for gestational age (HP:0001520)2.32197171
80Hyperactive renin-angiotensin system (HP:0000841)2.30757406
81Renal duplication (HP:0000075)2.28710758
82Hyperacusis (HP:0010780)2.27938292
83Down-sloping shoulders (HP:0200021)2.27456145
84Hypodontia (HP:0000668)2.27015604
85Absent eyebrow (HP:0002223)2.26876506
86Pili torti (HP:0003777)2.25938715
87Hypotrichosis (HP:0001006)2.22907612
88Bilateral microphthalmos (HP:0007633)2.22492076
89Exostoses (HP:0100777)2.21557043
90Aplasia involving forearm bones (HP:0009822)2.19359650
91Absent forearm bone (HP:0003953)2.19359650
92Oligodactyly (HP:0012165)2.19312521
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19174376
94Degeneration of the lateral corticospinal tracts (HP:0002314)2.19174376
95Woolly hair (HP:0002224)2.15110367
96Chronic hepatic failure (HP:0100626)2.14034734
97Absent radius (HP:0003974)2.13166398
98Urinary glycosaminoglycan excretion (HP:0003541)2.12420438
99Mucopolysacchariduria (HP:0008155)2.12420438
100Insomnia (HP:0100785)2.11434779
101Elfin facies (HP:0004428)2.09753240
102Cystic liver disease (HP:0006706)2.08298365
103Overriding aorta (HP:0002623)2.07873732
104Abnormality of the labia majora (HP:0012881)2.07610596
105Long toe (HP:0010511)2.06642126
106Toxemia of pregnancy (HP:0100603)2.05219612
107Micronodular cirrhosis (HP:0001413)2.04267723
108Bronchiectasis (HP:0002110)2.03045452
109Ridged nail (HP:0001807)2.00538938
110Failure to thrive in infancy (HP:0001531)2.00355481
111Abnormality of the fovea (HP:0000493)1.99533855
112Intestinal polyposis (HP:0200008)1.98951901
113Late onset (HP:0003584)1.98823671
114Cutaneous finger syndactyly (HP:0010554)1.98416781
115Obsessive-compulsive behavior (HP:0000722)1.98173635
116Popliteal pterygium (HP:0009756)1.97891604
117Abnormality of polysaccharide metabolism (HP:0011012)1.97488300
118Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97488300
119Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97488300
120Infantile muscular hypotonia (HP:0008947)1.97471880
121Abnormal biliary tract morphology (HP:0012440)1.97203267
122Aplasia/Hypoplasia of the nipples (HP:0006709)1.96655357
123Abnormality of the corticospinal tract (HP:0002492)1.94433673
124Abnormality of the pubic bones (HP:0003172)1.94131499
125Flat acetabular roof (HP:0003180)1.93219254
126Agitation (HP:0000713)1.92045448
127Renovascular hypertension (HP:0100817)1.91834020
128Leiomyosarcoma (HP:0100243)1.91679142
129Uterine leiomyosarcoma (HP:0002891)1.91679142
130Hypokalemia (HP:0002900)1.91475647
131Molar tooth sign on MRI (HP:0002419)1.91102558
132Abnormality of midbrain morphology (HP:0002418)1.91102558
133Arterial tortuosity (HP:0005116)1.90770241
134Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90515854
135Adrenal hypoplasia (HP:0000835)1.90279570
136Short nail (HP:0001799)1.90046106
137Increased number of teeth (HP:0011069)1.89385562
138Neoplasm of the heart (HP:0100544)1.88950296
139Skull defect (HP:0001362)1.88921341
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.88845353
141Polyphagia (HP:0002591)1.88624983
142Labial hypoplasia (HP:0000066)1.88283608
143Bowel diverticulosis (HP:0005222)1.86620742
144Ependymoma (HP:0002888)1.85918360
145Septate vagina (HP:0001153)1.85898014
146Round face (HP:0000311)1.85802897
147Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.85679111
148Low anterior hairline (HP:0000294)1.85485427
149Insulin resistance (HP:0000855)1.84321655
150Amelogenesis imperfecta (HP:0000705)1.83822399
151Protuberant abdomen (HP:0001538)1.83123438
152Renal agenesis (HP:0000104)1.81988692
153Spastic diplegia (HP:0001264)1.81877535
154Decreased circulating renin level (HP:0003351)1.81161749
155Slow-growing hair (HP:0002217)1.81090915
156Abnormality of hair growth rate (HP:0011363)1.81090915
157Abnormality of the intrinsic pathway (HP:0010989)1.79946400
158Morphological abnormality of the middle ear (HP:0008609)1.79276879
159True hermaphroditism (HP:0010459)1.78510038
160Lip pit (HP:0100267)1.78319600
161Intestinal polyp (HP:0005266)1.77587785
162Tracheomalacia (HP:0002779)1.77552281
163Ectopic anus (HP:0004397)1.77011987
164Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76128691
165Vertebral hypoplasia (HP:0008417)1.76128691
166Exocrine pancreatic insufficiency (HP:0001738)1.76093527
167Midline defect of the nose (HP:0004122)1.75404194
168Abnormal vertebral ossification (HP:0100569)1.74932686
169Anteriorly placed anus (HP:0001545)1.74700079
170Malignant gastrointestinal tract tumors (HP:0006749)1.74646142
171Gastrointestinal carcinoma (HP:0002672)1.74646142
172Curly hair (HP:0002212)1.73112344
173Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.72169716
174Tubulointerstitial nephritis (HP:0001970)1.69206245
175Abnormality of the distal phalanges of the toes (HP:0010182)1.68462547
176Papillary thyroid carcinoma (HP:0002895)1.67582585
177Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66657087
178Open mouth (HP:0000194)1.66416405
179Short metatarsal (HP:0010743)1.64490540
180Broad face (HP:0000283)1.61924352
181Hypoplastic pelvis (HP:0008839)1.61851357
182Natal tooth (HP:0000695)1.61777420
183Absent frontal sinuses (HP:0002688)1.61558012
184Aplasia cutis congenita (HP:0001057)1.61324233
185Vertebral clefting (HP:0008428)1.61016400
186Abnormal blistering of the skin (HP:0008066)1.60649966
187Abnormality of the astrocytes (HP:0100707)1.59953065
188Astrocytoma (HP:0009592)1.59953065
189Esophageal atresia (HP:0002032)1.59711323
190Sparse eyelashes (HP:0000653)1.59666295
191Hypoplastic female external genitalia (HP:0012815)1.59140424
192Broad nasal tip (HP:0000455)1.57583117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.36520531
2NEK14.53787906
3PASK4.50783042
4BCR4.46935481
5TRIM283.99668523
6NTRK23.99282614
7DDR23.67271285
8EPHA23.63762350
9STK38L3.24137532
10SIK33.19864970
11FER3.00815522
12PTK62.81193180
13MAPK152.48941309
14CSNK1A1L2.24996681
15HIPK22.13630085
16FRK2.13220619
17PRKD32.12477870
18PAK41.91619567
19MUSK1.89013412
20LMTK21.88907187
21CSNK1G31.88293527
22MAP3K21.83882159
23EPHB21.83108331
24SIK11.74636248
25MATK1.68091147
26CSNK1G11.62025312
27TAOK31.59675438
28CSNK1G21.59202025
29KSR11.56936558
30CDK61.50932405
31PDGFRA1.50660354
32UHMK11.41524352
33LATS11.41427870
34MAPKAPK31.37465237
35TESK11.29623932
36MINK11.29293063
37CDC42BPA1.28722189
38STK381.27515726
39EPHA41.26313056
40TNIK1.15979686
41EPHB11.15620791
42DYRK1B1.15198366
43WNK41.14416822
44PIK3CA1.14241516
45NTRK11.13828523
46MAP4K21.13724082
47CSF1R1.13697924
48NTRK31.12355629
49STK391.10731379
50EPHA31.09382213
51MAP3K11.09310646
52ERBB21.07179052
53RIPK11.05657799
54PKN21.03040740
55BCKDK1.02664895
56PRKCH1.01468272
57MAP3K121.01433171
58DYRK31.00514275
59MST41.00120916
60PAK30.95379376
61SRPK10.90861852
62MARK20.88119197
63STK240.86388681
64MAPKAPK50.85278155
65MET0.84967723
66PTK20.84601692
67MARK10.84430870
68ERN10.84273082
69PRKD20.81655052
70PRKD10.81278812
71MAP2K40.81167200
72WNK30.78951719
73CAMK1G0.74775690
74CASK0.74616336
75YES10.74151550
76FGFR20.74112643
77WNK10.71373996
78MAP3K60.67638273
79MAP3K40.66855787
80ICK0.65990184
81CDK50.65621006
82ARAF0.61320802
83ERBB30.61111297
84PIK3CG0.60816822
85CHUK0.60303771
86NEK60.60108412
87GSK3A0.59220739
88PIM20.58831233
89STK110.57888630
90KSR20.57061841
91OXSR10.56975532
92RPS6KB20.56537395
93TRIB30.55993896
94BMPR1B0.54501174
95FGFR30.52977018
96PRKCI0.52187350
97CAMKK20.51857079
98NME10.51843946
99JAK20.49439743
100PRKCE0.48025352
101ADRBK10.46937656
102FLT30.46724040
103CAMK2B0.46149107
104BRSK20.43061733
105FGFR10.42771271
106PRKAA10.42571714
107TAOK10.42504096
108CAMK2D0.42278879
109BTK0.41885407
110ROCK20.41677519
111RPS6KA20.41004370
112DYRK1A0.38006511
113CAMK2G0.37973901
114NEK20.36943377
115CSNK1A10.36942598
116ROCK10.36345781
117RET0.35835369
118MAP2K70.35564042
119TTK0.35223644
120ATM0.34663109
121IGF1R0.32987881
122PRKDC0.32753435
123EGFR0.31842935
124SCYL20.31535728
125AKT30.30642762
126MAP3K70.30194818
127RPS6KB10.29794778
128FYN0.29554025
129CAMKK10.29508593
130MKNK10.28606027
131PRKACB0.27802774
132SRC0.27706414
133PNCK0.27435774
134CAMK1D0.27047242
135AKT20.26963919
136CAMK2A0.26710624
137EIF2AK20.26411880
138MAPK90.25629087
139DYRK20.25018939
140PRKCZ0.23994995
141CSNK1D0.23913362
142MTOR0.23583555
143SGK30.23566445
144SGK20.23397971
145PRKACG0.23266010
146TGFBR10.22979315
147MAPK100.22923714
148SGK10.22805411
149MST1R0.22533679
150MAP3K110.22527991
151PLK10.22109835
152MAP2K10.22107810
153PDGFRB0.21860076
154BRD40.20633419
155PRKACA0.19801448

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.40943785
2Insulin secretion_Homo sapiens_hsa049113.36840375
3Protein export_Homo sapiens_hsa030603.12299092
4Steroid biosynthesis_Homo sapiens_hsa001002.68563960
5Type II diabetes mellitus_Homo sapiens_hsa049302.58645263
6Caffeine metabolism_Homo sapiens_hsa002322.55017180
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.53298418
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.32149986
9Sulfur metabolism_Homo sapiens_hsa009202.21852318
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.07482468
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94892655
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64753592
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64615578
14Circadian entrainment_Homo sapiens_hsa047131.59547418
15Renin secretion_Homo sapiens_hsa049241.57812134
16Sphingolipid metabolism_Homo sapiens_hsa006001.57493525
17Basal cell carcinoma_Homo sapiens_hsa052171.56849764
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.54379257
19Cocaine addiction_Homo sapiens_hsa050301.51984187
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49512730
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.46772640
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45728837
23Taste transduction_Homo sapiens_hsa047421.44340480
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.43344722
25Amphetamine addiction_Homo sapiens_hsa050311.37120873
26N-Glycan biosynthesis_Homo sapiens_hsa005101.34545480
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30802022
28Long-term potentiation_Homo sapiens_hsa047201.30484777
29Melanogenesis_Homo sapiens_hsa049161.23634601
30Vibrio cholerae infection_Homo sapiens_hsa051101.21202867
31Pancreatic secretion_Homo sapiens_hsa049721.20288843
32Thyroid cancer_Homo sapiens_hsa052161.20254862
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.19816121
34ErbB signaling pathway_Homo sapiens_hsa040121.18420317
35Lysine degradation_Homo sapiens_hsa003101.17923528
36Hedgehog signaling pathway_Homo sapiens_hsa043401.17399127
37Linoleic acid metabolism_Homo sapiens_hsa005911.14776997
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14644023
39Protein digestion and absorption_Homo sapiens_hsa049741.13531864
40GABAergic synapse_Homo sapiens_hsa047271.12183166
41Type I diabetes mellitus_Homo sapiens_hsa049401.11843239
42Butanoate metabolism_Homo sapiens_hsa006501.10735066
43Fatty acid metabolism_Homo sapiens_hsa012121.10046246
44Circadian rhythm_Homo sapiens_hsa047101.05171791
45Hippo signaling pathway_Homo sapiens_hsa043901.03165644
46Wnt signaling pathway_Homo sapiens_hsa043101.02652832
47Serotonergic synapse_Homo sapiens_hsa047261.01080779
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99481960
49Dopaminergic synapse_Homo sapiens_hsa047280.99175701
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98276068
51Inositol phosphate metabolism_Homo sapiens_hsa005620.98164567
52ECM-receptor interaction_Homo sapiens_hsa045120.96220793
53Insulin resistance_Homo sapiens_hsa049310.94667424
54Endometrial cancer_Homo sapiens_hsa052130.92124753
55Vitamin digestion and absorption_Homo sapiens_hsa049770.92084958
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91906503
57Thyroid hormone synthesis_Homo sapiens_hsa049180.91676489
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.91411634
59Starch and sucrose metabolism_Homo sapiens_hsa005000.90406499
60Propanoate metabolism_Homo sapiens_hsa006400.89904786
61Gap junction_Homo sapiens_hsa045400.89631376
62TGF-beta signaling pathway_Homo sapiens_hsa043500.89352091
63Fatty acid elongation_Homo sapiens_hsa000620.89290187
64Fatty acid biosynthesis_Homo sapiens_hsa000610.88206473
65Adherens junction_Homo sapiens_hsa045200.87959373
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87405859
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87164412
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86650281
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86047532
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.85224670
71Dorso-ventral axis formation_Homo sapiens_hsa043200.85138398
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84994513
73Histidine metabolism_Homo sapiens_hsa003400.84193882
74Prostate cancer_Homo sapiens_hsa052150.83691464
75Estrogen signaling pathway_Homo sapiens_hsa049150.83603314
76Glucagon signaling pathway_Homo sapiens_hsa049220.82462562
77AMPK signaling pathway_Homo sapiens_hsa041520.82183559
78Cholinergic synapse_Homo sapiens_hsa047250.82030885
79Insulin signaling pathway_Homo sapiens_hsa049100.81673772
80Nicotine addiction_Homo sapiens_hsa050330.79143023
81Selenocompound metabolism_Homo sapiens_hsa004500.78450250
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78412286
83Small cell lung cancer_Homo sapiens_hsa052220.78347883
84Bladder cancer_Homo sapiens_hsa052190.77946693
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77782705
86Axon guidance_Homo sapiens_hsa043600.77090621
87Chemical carcinogenesis_Homo sapiens_hsa052040.76860227
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75439353
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74172251
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73489272
91Tyrosine metabolism_Homo sapiens_hsa003500.73216208
92Glutamatergic synapse_Homo sapiens_hsa047240.70988885
93cAMP signaling pathway_Homo sapiens_hsa040240.70103709
94mTOR signaling pathway_Homo sapiens_hsa041500.69111179
95Endocytosis_Homo sapiens_hsa041440.69012037
96Lysosome_Homo sapiens_hsa041420.68851420
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68746259
98Amoebiasis_Homo sapiens_hsa051460.68648401
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65685765
100Fat digestion and absorption_Homo sapiens_hsa049750.63793172
101Morphine addiction_Homo sapiens_hsa050320.63432389
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.62017426
103Prolactin signaling pathway_Homo sapiens_hsa049170.61037328
104Prion diseases_Homo sapiens_hsa050200.60049093
105Basal transcription factors_Homo sapiens_hsa030220.58722034
106Focal adhesion_Homo sapiens_hsa045100.58010660
107Ether lipid metabolism_Homo sapiens_hsa005650.57897381
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57227099
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57146089
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56263091
111Choline metabolism in cancer_Homo sapiens_hsa052310.56090950
112Peroxisome_Homo sapiens_hsa041460.55735067
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55321679
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54139154
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53430835
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51970947
117ABC transporters_Homo sapiens_hsa020100.51922205
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51821350
119Oocyte meiosis_Homo sapiens_hsa041140.51780231
120Notch signaling pathway_Homo sapiens_hsa043300.50687543
121Dilated cardiomyopathy_Homo sapiens_hsa054140.50536501
122Retinol metabolism_Homo sapiens_hsa008300.49794452
123Fatty acid degradation_Homo sapiens_hsa000710.49707612
124Regulation of autophagy_Homo sapiens_hsa041400.49660548
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49505282
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49229016
127beta-Alanine metabolism_Homo sapiens_hsa004100.49190371
128Synaptic vesicle cycle_Homo sapiens_hsa047210.48791971
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48187598
130Renal cell carcinoma_Homo sapiens_hsa052110.48117255
131GnRH signaling pathway_Homo sapiens_hsa049120.47735716
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45165324
133Proteoglycans in cancer_Homo sapiens_hsa052050.44956137
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44428239
135Calcium signaling pathway_Homo sapiens_hsa040200.44361935
136Long-term depression_Homo sapiens_hsa047300.43453976
137MicroRNAs in cancer_Homo sapiens_hsa052060.42747062
138Tight junction_Homo sapiens_hsa045300.41785869
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41320912
140Phenylalanine metabolism_Homo sapiens_hsa003600.40966394
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40735527
142Alcoholism_Homo sapiens_hsa050340.39343716
143Ovarian steroidogenesis_Homo sapiens_hsa049130.38692430
144Gastric acid secretion_Homo sapiens_hsa049710.38346418
145Ras signaling pathway_Homo sapiens_hsa040140.37405682
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37156417
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36886394

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