SLITRK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)6.04280928
2neuron cell-cell adhesion (GO:0007158)5.74174606
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.56415593
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.41486088
5synaptic vesicle exocytosis (GO:0016079)5.28858299
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.20271453
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.13420747
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.10967538
9protein localization to synapse (GO:0035418)5.07846311
10regulation of glutamate receptor signaling pathway (GO:1900449)5.02750211
11presynaptic membrane assembly (GO:0097105)4.98094805
12glutamate secretion (GO:0014047)4.95022286
13glutamate receptor signaling pathway (GO:0007215)4.88568802
14neurotransmitter-gated ion channel clustering (GO:0072578)4.80115403
15behavioral response to nicotine (GO:0035095)4.74147196
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.72589474
17regulation of synaptic vesicle exocytosis (GO:2000300)4.64514222
18neuronal action potential propagation (GO:0019227)4.63584723
19presynaptic membrane organization (GO:0097090)4.59273958
20locomotory exploration behavior (GO:0035641)4.56730344
21synaptic transmission, glutamatergic (GO:0035249)4.54307084
22neuron-neuron synaptic transmission (GO:0007270)4.53522222
23postsynaptic membrane organization (GO:0001941)4.46544331
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.40460215
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.39765222
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.34164053
27exploration behavior (GO:0035640)4.18715212
28regulation of synaptic vesicle transport (GO:1902803)4.18606755
29neurotransmitter secretion (GO:0007269)4.16121028
30synaptic vesicle maturation (GO:0016188)4.11343489
31positive regulation of synapse maturation (GO:0090129)4.09693753
32regulation of long-term neuronal synaptic plasticity (GO:0048169)4.00150454
33neuron recognition (GO:0008038)3.96071919
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.95431241
35response to histamine (GO:0034776)3.94491994
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.93684013
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.89370104
38long-term synaptic potentiation (GO:0060291)3.86190474
39cerebellar granule cell differentiation (GO:0021707)3.82176207
40regulation of postsynaptic membrane potential (GO:0060078)3.79815450
41pyrimidine nucleobase catabolic process (GO:0006208)3.76532971
42regulation of neuronal synaptic plasticity (GO:0048168)3.76290899
43regulation of synaptic transmission, glutamatergic (GO:0051966)3.73242117
44negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.72890908
45startle response (GO:0001964)3.70594581
46long-term memory (GO:0007616)3.65836637
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63677803
48gamma-aminobutyric acid transport (GO:0015812)3.59921258
49serotonin metabolic process (GO:0042428)3.57012963
50axonal fasciculation (GO:0007413)3.53641250
51positive regulation of membrane potential (GO:0045838)3.53258527
52regulation of synaptic plasticity (GO:0048167)3.46985110
53regulation of synapse maturation (GO:0090128)3.46928902
54neurotransmitter transport (GO:0006836)3.45553658
55transmission of nerve impulse (GO:0019226)3.45313869
56positive regulation of synapse assembly (GO:0051965)3.41899195
57positive regulation of potassium ion transmembrane transport (GO:1901381)3.39433046
58positive regulation of neurotransmitter secretion (GO:0001956)3.39077770
59synapse assembly (GO:0007416)3.35218379
60regulation of synapse structural plasticity (GO:0051823)3.35215515
61behavioral defense response (GO:0002209)3.34458376
62behavioral fear response (GO:0001662)3.34458376
63proline transport (GO:0015824)3.33634819
64regulation of neurotransmitter secretion (GO:0046928)3.32469042
65cerebellar Purkinje cell differentiation (GO:0021702)3.32400669
66primary amino compound metabolic process (GO:1901160)3.28494711
67auditory behavior (GO:0031223)3.25782747
68regulation of glutamate secretion (GO:0014048)3.25707778
69synaptic vesicle endocytosis (GO:0048488)3.24856060
70mechanosensory behavior (GO:0007638)3.24041322
71membrane depolarization (GO:0051899)3.23725619
72fear response (GO:0042596)3.21655264
73positive regulation of neurotransmitter transport (GO:0051590)3.18873013
74regulation of neurotransmitter levels (GO:0001505)3.18456263
75negative regulation of appetite (GO:0032099)3.17361258
76negative regulation of response to food (GO:0032096)3.17361258
77learning (GO:0007612)3.16448744
78positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16318579
79neuronal action potential (GO:0019228)3.15993003
80dendritic spine morphogenesis (GO:0060997)3.15624411
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13097630
82regulation of dendritic spine morphogenesis (GO:0061001)3.12423183
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12020361
84protein polyglutamylation (GO:0018095)3.09885338
85nucleobase catabolic process (GO:0046113)3.09738613
86innervation (GO:0060384)3.09592503
87synaptic transmission (GO:0007268)3.09187438
88regulation of neurotransmitter uptake (GO:0051580)3.09074712
89regulation of vesicle fusion (GO:0031338)3.08994303
90cell proliferation in forebrain (GO:0021846)3.07651899
91behavioral response to cocaine (GO:0048148)3.07148562
92positive regulation of synaptic transmission (GO:0050806)3.06785742
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05934748
94regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.05313728
95regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.05313728
96regulation of membrane repolarization (GO:0060306)3.04484736
97regulation of neurotransmitter transport (GO:0051588)3.04348265
98layer formation in cerebral cortex (GO:0021819)3.03717581
99membrane hyperpolarization (GO:0060081)3.03053166
100membrane depolarization during action potential (GO:0086010)3.01964832
101response to auditory stimulus (GO:0010996)3.01062114
102short-term memory (GO:0007614)3.00911675
103negative regulation of dendrite morphogenesis (GO:0050774)3.00555836
104cochlea development (GO:0090102)2.99629191
105regulation of synaptic transmission (GO:0050804)2.98543507
106regulation of synapse assembly (GO:0051963)2.97467441
107positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.97407380
108detection of calcium ion (GO:0005513)2.96709640
109negative regulation of neurotransmitter transport (GO:0051589)2.94967470
110response to amphetamine (GO:0001975)2.94939311
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93771606
112cellular potassium ion homeostasis (GO:0030007)2.93449584
113somite development (GO:0061053)2.91971719
114ATP hydrolysis coupled proton transport (GO:0015991)2.91011165
115energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91011165
116long term synaptic depression (GO:0060292)2.90338810
117regulation of synaptic transmission, GABAergic (GO:0032228)2.89466035
118activation of protein kinase A activity (GO:0034199)2.88793787
119negative regulation of dendrite development (GO:2000171)2.88647847
120regulation of action potential (GO:0098900)2.87524319
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84708857
122neurofilament cytoskeleton organization (GO:0060052)2.81105618
123action potential (GO:0001508)2.80488295
124sulfation (GO:0051923)2.79896270
125regulation of voltage-gated calcium channel activity (GO:1901385)2.79817251
126dopamine transport (GO:0015872)2.78774009
127multicellular organismal signaling (GO:0035637)2.76384419
128behavioral response to ethanol (GO:0048149)2.75675843
129adaptation of signaling pathway (GO:0023058)2.73840774
130membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.70975147
131mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63943552
132mitochondrial respiratory chain complex I assembly (GO:0032981)2.63943552
133NADH dehydrogenase complex assembly (GO:0010257)2.63943552
134positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.62909697
135neuromuscular synaptic transmission (GO:0007274)2.61747128
136positive regulation of amino acid transport (GO:0051957)2.59617145
137regulation of dopamine secretion (GO:0014059)2.58275380
138regulation of response to food (GO:0032095)2.56256528
139adult walking behavior (GO:0007628)2.55608209
140neuromuscular process controlling posture (GO:0050884)2.54251085
141regulation of female receptivity (GO:0045924)2.53972421
142adult behavior (GO:0030534)2.53589614
143cAMP catabolic process (GO:0006198)2.52313444
144potassium ion import (GO:0010107)2.51386967
145membrane repolarization during action potential (GO:0086011)2.51127915
146regulation of potassium ion transmembrane transport (GO:1901379)2.50922010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.82990377
2GBX2_23144817_ChIP-Seq_PC3_Human4.49129741
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09803666
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00346647
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98310098
6TAF15_26573619_Chip-Seq_HEK293_Human2.72762786
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60278541
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51334143
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51334143
10REST_21632747_ChIP-Seq_MESCs_Mouse2.49454252
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48473876
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.47456577
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44232753
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42262377
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39716873
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.32513348
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30995334
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26953493
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25595270
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22425171
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16253137
22* RNF2_27304074_Chip-Seq_ESCs_Mouse1.99951275
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97854643
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.96456761
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96161438
26DROSHA_22980978_ChIP-Seq_HELA_Human1.94545576
27SMAD4_21799915_ChIP-Seq_A2780_Human1.93871981
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93457958
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.93330719
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93246671
31P300_19829295_ChIP-Seq_ESCs_Human1.93109742
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.92582489
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91624259
34AR_21572438_ChIP-Seq_LNCaP_Human1.90524544
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87548287
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86856297
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85722376
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84242524
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75511778
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73162961
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72840625
42FUS_26573619_Chip-Seq_HEK293_Human1.70214238
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.62507794
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.60012471
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.57399182
46VDR_22108803_ChIP-Seq_LS180_Human1.55295938
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54267909
48IGF1R_20145208_ChIP-Seq_DFB_Human1.53179287
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51418008
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50179638
51AR_25329375_ChIP-Seq_VCAP_Human1.49231848
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.45903736
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45612659
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44395799
55* RNF2_27304074_Chip-Seq_NSC_Mouse1.43511722
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41867672
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40058981
58ZNF274_21170338_ChIP-Seq_K562_Hela1.38908144
59STAT3_23295773_ChIP-Seq_U87_Human1.36428359
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35864483
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32382571
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31772852
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29378541
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26825374
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26356500
66ER_23166858_ChIP-Seq_MCF-7_Human1.25266302
67TCF4_23295773_ChIP-Seq_U87_Human1.24913683
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22610001
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.19964530
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19271336
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18855790
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.18081709
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.17597912
74JUN_21703547_ChIP-Seq_K562_Human1.16977641
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16914809
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16656740
77CBP_20019798_ChIP-Seq_JUKART_Human1.16656740
78* RUNX2_22187159_ChIP-Seq_PCA_Human1.16394563
79TP53_18474530_ChIP-ChIP_U2OS_Human1.16310940
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14512277
81TP53_16413492_ChIP-PET_HCT116_Human1.11529436
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.09927782
83AR_19668381_ChIP-Seq_PC3_Human1.09500416
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.08958193
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08841353
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08841353
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08129922
88IRF1_19129219_ChIP-ChIP_H3396_Human1.07464524
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.06858165
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.05214736
91AHR_22903824_ChIP-Seq_MCF-7_Human1.04912771
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.04704048
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.04655814
94BCAT_22108803_ChIP-Seq_LS180_Human1.04453900
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04093823
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03197893
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02750135
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02342360
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01984845
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01322313
101EWS_26573619_Chip-Seq_HEK293_Human1.01198363
102KDM2B_26808549_Chip-Seq_REH_Human1.00883705
103* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00794305
104TCF4_22108803_ChIP-Seq_LS180_Human0.99887532
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99717769
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99264567
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98920110
108P53_22387025_ChIP-Seq_ESCs_Mouse0.98882464
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98471001
110KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98024947
111SMAD4_21741376_ChIP-Seq_EPCs_Human0.97595757
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96819075
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.96583555
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96400299
115SOX9_26525672_Chip-Seq_HEART_Mouse0.96018539
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95716090
117CMYC_18555785_Chip-Seq_ESCs_Mouse0.95672117
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93632514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.58811494
2MP0003880_abnormal_central_pattern5.57785590
3MP0003635_abnormal_synaptic_transmissio4.02328150
4MP0009745_abnormal_behavioral_response3.53790396
5MP0004270_analgesia3.34806336
6MP0009046_muscle_twitch3.32932839
7MP0002063_abnormal_learning/memory/cond3.29642913
8MP0001968_abnormal_touch/_nociception3.24916018
9MP0002064_seizures3.22852557
10MP0002572_abnormal_emotion/affect_behav2.95506719
11MP0002736_abnormal_nociception_after2.89119838
12MP0002272_abnormal_nervous_system2.71271881
13MP0002735_abnormal_chemical_nociception2.69758564
14MP0001501_abnormal_sleep_pattern2.56850326
15MP0001486_abnormal_startle_reflex2.54707882
16MP0002734_abnormal_mechanical_nocicepti2.53012796
17MP0005423_abnormal_somatic_nervous2.43703278
18MP0001440_abnormal_grooming_behavior2.26867318
19MP0002067_abnormal_sensory_capabilities2.22737529
20MP0001188_hyperpigmentation2.18603842
21MP0006276_abnormal_autonomic_nervous2.11328740
22MP0002822_catalepsy2.03927000
23MP0002733_abnormal_thermal_nociception1.97108915
24MP0002184_abnormal_innervation1.96132054
25MP0001529_abnormal_vocalization1.93292106
26MP0005646_abnormal_pituitary_gland1.91864680
27MP0001970_abnormal_pain_threshold1.90363660
28MP0009780_abnormal_chondrocyte_physiolo1.90082377
29MP0000778_abnormal_nervous_system1.89181680
30MP0003787_abnormal_imprinting1.81397379
31MP0002557_abnormal_social/conspecific_i1.81175751
32MP0005386_behavior/neurological_phenoty1.79908681
33MP0004924_abnormal_behavior1.79908681
34MP0003879_abnormal_hair_cell1.77346503
35MP0001984_abnormal_olfaction1.71195383
36MP0008569_lethality_at_weaning1.58511651
37MP0003122_maternal_imprinting1.56082509
38MP0001905_abnormal_dopamine_level1.52029054
39MP0003646_muscle_fatigue1.50154669
40MP0005645_abnormal_hypothalamus_physiol1.47774818
41MP0004811_abnormal_neuron_physiology1.47213461
42MP0006072_abnormal_retinal_apoptosis1.46475303
43MP0004142_abnormal_muscle_tone1.44590174
44MP0003329_amyloid_beta_deposits1.44021624
45MP0004133_heterotaxia1.42333961
46MP0002066_abnormal_motor_capabilities/c1.38449073
47MP0000955_abnormal_spinal_cord1.38136986
48MP0000569_abnormal_digit_pigmentation1.34836879
49MP0000049_abnormal_middle_ear1.34239065
50MP0002837_dystrophic_cardiac_calcinosis1.32399385
51MP0002882_abnormal_neuron_morphology1.32374128
52MP0004858_abnormal_nervous_system1.30678267
53MP0002876_abnormal_thyroid_physiology1.27387773
54MP0001502_abnormal_circadian_rhythm1.27061975
55MP0003283_abnormal_digestive_organ1.25728424
56MP0004742_abnormal_vestibular_system1.21458714
57MP0002909_abnormal_adrenal_gland1.19869240
58MP0005253_abnormal_eye_physiology1.13339244
59MP0003633_abnormal_nervous_system1.12780430
60MP0003011_delayed_dark_adaptation1.12152500
61MP0003938_abnormal_ear_development1.08439100
62MP0004130_abnormal_muscle_cell1.08394456
63MP0010386_abnormal_urinary_bladder1.07723058
64MP0005171_absent_coat_pigmentation1.06283935
65MP0002160_abnormal_reproductive_system1.03803245
66MP0004885_abnormal_endolymph1.03257827
67MP0004145_abnormal_muscle_electrophysio1.01897666
68MP0004147_increased_porphyrin_level1.01768613
69MP0009379_abnormal_foot_pigmentation1.00926840
70MP0002152_abnormal_brain_morphology1.00706028
71MP0003631_nervous_system_phenotype0.99815851
72MP0005084_abnormal_gallbladder_morpholo0.99060862
73MP0001963_abnormal_hearing_physiology0.98729608
74MP0005409_darkened_coat_color0.97206807
75MP0002928_abnormal_bile_duct0.93624907
76MP0003119_abnormal_digestive_system0.93552475
77MP0008872_abnormal_physiological_respon0.91833031
78MP0005551_abnormal_eye_electrophysiolog0.91036205
79MP0004484_altered_response_of0.91032778
80MP0000751_myopathy0.90578843
81MP0004085_abnormal_heartbeat0.89530856
82MP0002229_neurodegeneration0.88037584
83MP0002234_abnormal_pharynx_morphology0.87621132
84MP0004215_abnormal_myocardial_fiber0.87358873
85MP0005195_abnormal_posterior_eye0.87181472
86MP0002069_abnormal_eating/drinking_beha0.85587956
87MP0008874_decreased_physiological_sensi0.82868608
88MP0000631_abnormal_neuroendocrine_gland0.82849593
89MP0005389_reproductive_system_phenotype0.81364797
90MP0003136_yellow_coat_color0.80866145
91MP0009250_abnormal_appendicular_skeleto0.77979421
92MP0002752_abnormal_somatic_nervous0.77065301
93MP0001485_abnormal_pinna_reflex0.76431723
94MP0005499_abnormal_olfactory_system0.76360952
95MP0005394_taste/olfaction_phenotype0.76360952
96MP0000013_abnormal_adipose_tissue0.75844917
97MP0001293_anophthalmia0.75665373
98MP0001664_abnormal_digestion0.75353495
99MP0005535_abnormal_body_temperature0.73963866
100MP0001986_abnormal_taste_sensitivity0.73428625
101MP0002653_abnormal_ependyma_morphology0.70712254
102MP0000230_abnormal_systemic_arterial0.70323253
103MP0005167_abnormal_blood-brain_barrier0.70179231
104MP0003121_genomic_imprinting0.69912033
105MP0000026_abnormal_inner_ear0.69221325
106MP0003937_abnormal_limbs/digits/tail_de0.67920939
107MP0003632_abnormal_nervous_system0.66675226
108MP0001177_atelectasis0.66078497
109MP0003634_abnormal_glial_cell0.64956909
110MP0004043_abnormal_pH_regulation0.63876098
111MP0004134_abnormal_chest_morphology0.62305385
112MP0002102_abnormal_ear_morphology0.62126150
113MP0003183_abnormal_peptide_metabolism0.60842348
114MP0003137_abnormal_impulse_conducting0.59403390
115MP0002638_abnormal_pupillary_reflex0.57448950
116MP0001943_abnormal_respiration0.57432740
117MP0006292_abnormal_olfactory_placode0.54871231
118MP0003123_paternal_imprinting0.53894114
119MP0008877_abnormal_DNA_methylation0.53721482
120MP0000604_amyloidosis0.53687017
121MP0000015_abnormal_ear_pigmentation0.53037525
122MP0002082_postnatal_lethality0.52098720
123MP0010770_preweaning_lethality0.52098720
124MP0010769_abnormal_survival0.49775216
125MP0000920_abnormal_myelination0.48852820
126MP0003861_abnormal_nervous_system0.47275444
127MP0004233_abnormal_muscle_weight0.47121921
128MP0010768_mortality/aging0.46952105

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.57167077
2Epileptic encephalopathy (HP:0200134)5.97320881
3Focal seizures (HP:0007359)5.87935579
4Atonic seizures (HP:0010819)5.85393598
5Hyperventilation (HP:0002883)5.49396753
6Febrile seizures (HP:0002373)5.38987892
7Myokymia (HP:0002411)5.31580456
8Absence seizures (HP:0002121)4.61956994
9Progressive cerebellar ataxia (HP:0002073)4.38148127
10Dialeptic seizures (HP:0011146)4.31893053
11Visual hallucinations (HP:0002367)4.24655117
12Broad-based gait (HP:0002136)4.24577864
13Generalized tonic-clonic seizures (HP:0002069)3.96377898
14Gaze-evoked nystagmus (HP:0000640)3.37972630
15Poor eye contact (HP:0000817)3.25680580
16Drooling (HP:0002307)3.24443138
17Excessive salivation (HP:0003781)3.24443138
18Congenital stationary night blindness (HP:0007642)3.11872196
19Amblyopia (HP:0000646)3.11530854
20Protruding tongue (HP:0010808)3.03179441
21Pancreatic cysts (HP:0001737)3.02541823
22Nephronophthisis (HP:0000090)3.00034284
23True hermaphroditism (HP:0010459)2.98286063
24Absent speech (HP:0001344)2.96308474
25Impaired social interactions (HP:0000735)2.93698056
26Abnormal social behavior (HP:0012433)2.93698056
27Epileptiform EEG discharges (HP:0011182)2.92822233
28Progressive inability to walk (HP:0002505)2.91091597
29Pheochromocytoma (HP:0002666)2.91009958
30Pancreatic fibrosis (HP:0100732)2.88497837
31Inability to walk (HP:0002540)2.87787057
32Abnormality of midbrain morphology (HP:0002418)2.87761308
33Molar tooth sign on MRI (HP:0002419)2.87761308
34Fetal akinesia sequence (HP:0001989)2.85009610
35Truncal ataxia (HP:0002078)2.84152968
36Impaired vibration sensation in the lower limbs (HP:0002166)2.83279702
37Dysdiadochokinesis (HP:0002075)2.82570255
38Limb dystonia (HP:0002451)2.80129417
39Action tremor (HP:0002345)2.79973566
40Abnormality of binocular vision (HP:0011514)2.78586038
41Diplopia (HP:0000651)2.78586038
42Abnormal eating behavior (HP:0100738)2.77735397
43Abolished electroretinogram (ERG) (HP:0000550)2.74037235
44Neuroendocrine neoplasm (HP:0100634)2.67474348
45Anxiety (HP:0000739)2.67445638
46Stenosis of the external auditory canal (HP:0000402)2.66624517
47EEG with generalized epileptiform discharges (HP:0011198)2.61929974
48Dysmetria (HP:0001310)2.60624528
49Polyphagia (HP:0002591)2.60373697
50Blue irides (HP:0000635)2.60009422
51Hemiplegia (HP:0002301)2.58757355
52Abnormal hair whorl (HP:0010721)2.58397646
53Type II lissencephaly (HP:0007260)2.57404547
54Gait imbalance (HP:0002141)2.50342596
55Pendular nystagmus (HP:0012043)2.47313392
56Supranuclear gaze palsy (HP:0000605)2.45517324
57Scanning speech (HP:0002168)2.44520167
58Urinary bladder sphincter dysfunction (HP:0002839)2.44263434
59Depression (HP:0000716)2.43390844
60Abnormality of the renal medulla (HP:0100957)2.41060756
61Hypsarrhythmia (HP:0002521)2.39076389
62Abnormal rod and cone electroretinograms (HP:0008323)2.35854072
63Genetic anticipation (HP:0003743)2.33441881
64Impaired smooth pursuit (HP:0007772)2.32254685
65Abnormality of the renal collecting system (HP:0004742)2.30709156
66Fair hair (HP:0002286)2.27270225
67Abnormality of the corticospinal tract (HP:0002492)2.27094376
68Abnormality of salivation (HP:0100755)2.23762624
69Megalencephaly (HP:0001355)2.23293673
70Insidious onset (HP:0003587)2.23232336
71Termporal pattern (HP:0011008)2.23232336
72Hemiparesis (HP:0001269)2.20845627
73Congenital, generalized hypertrichosis (HP:0004540)2.17926310
74Morphological abnormality of the middle ear (HP:0008609)2.16505760
75Optic nerve hypoplasia (HP:0000609)2.15537132
76Generalized hypopigmentation of hair (HP:0011358)2.15316726
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.14808891
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14410969
79Hyperthyroidism (HP:0000836)2.13845446
80Bradykinesia (HP:0002067)2.12812382
81Medial flaring of the eyebrow (HP:0010747)2.12702235
82Septo-optic dysplasia (HP:0100842)2.11399199
83Decreased circulating renin level (HP:0003351)2.11193022
84Dysmetric saccades (HP:0000641)2.11107793
85Status epilepticus (HP:0002133)2.10860437
86Symphalangism affecting the phalanges of the hand (HP:0009773)2.10056030
87Congenital primary aphakia (HP:0007707)2.09635658
88Cerebral inclusion bodies (HP:0100314)2.09614735
89Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09240065
90Mutism (HP:0002300)2.09041994
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09008343
92Stereotypic behavior (HP:0000733)2.07791504
93Urinary urgency (HP:0000012)2.07394056
94Abnormality of the renal cortex (HP:0011035)2.06635240
95Ankle clonus (HP:0011448)2.06371151
96Postural instability (HP:0002172)2.04025468
97Failure to thrive in infancy (HP:0001531)2.03511647
98Nephrogenic diabetes insipidus (HP:0009806)2.02681437
99Generalized myoclonic seizures (HP:0002123)2.02219055
100Poor suck (HP:0002033)2.01429608
101Acute necrotizing encephalopathy (HP:0006965)2.00161894
102Impaired vibratory sensation (HP:0002495)1.98896879
103Abnormality of the middle phalanges of the toes (HP:0010183)1.98175390
104Abnormality of ocular smooth pursuit (HP:0000617)1.98131588
105Decreased central vision (HP:0007663)1.97106104
106Thickened helices (HP:0000391)1.96717516
107Short tibia (HP:0005736)1.96627812
108Genital tract atresia (HP:0001827)1.96489507
109Vaginal atresia (HP:0000148)1.96473077
110Spastic gait (HP:0002064)1.95060467
111Morphological abnormality of the pyramidal tract (HP:0002062)1.94986647
112Dyskinesia (HP:0100660)1.93001972
113Specific learning disability (HP:0001328)1.92721629
114Widely spaced teeth (HP:0000687)1.92210603
115Progressive macrocephaly (HP:0004481)1.91494625
116Incomplete penetrance (HP:0003829)1.91422058
117Keratoconus (HP:0000563)1.91100015
118Increased corneal curvature (HP:0100692)1.91100015
119Lissencephaly (HP:0001339)1.90279449
120Humeroradial synostosis (HP:0003041)1.89789516
121Synostosis involving the elbow (HP:0003938)1.89789516
122Esotropia (HP:0000565)1.89278201
123Gait ataxia (HP:0002066)1.89241948
124Akinesia (HP:0002304)1.88962572
125Absent/shortened dynein arms (HP:0200106)1.88493043
126Dynein arm defect of respiratory motile cilia (HP:0012255)1.88493043
127Inappropriate behavior (HP:0000719)1.87429529
128Abnormal mitochondria in muscle tissue (HP:0008316)1.87377229
129Pachygyria (HP:0001302)1.86951288
130Exotropia (HP:0000577)1.86644908
131Aplasia/Hypoplasia of the hallux (HP:0008362)1.86066009
132Short hallux (HP:0010109)1.85813877
133Abnormality of the proximal phalanges of the hand (HP:0009834)1.85364307
134Torticollis (HP:0000473)1.84959958
135Gastroesophageal reflux (HP:0002020)1.84798936
136Neurofibrillary tangles (HP:0002185)1.84748910
137Myotonia (HP:0002486)1.83203234
138Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.82769818
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82065593
140Degeneration of the lateral corticospinal tracts (HP:0002314)1.82065593
141Agitation (HP:0000713)1.80718183
142Abnormality of the lower motor neuron (HP:0002366)1.80632036
143Abnormality of the labia minora (HP:0012880)1.79856256
144Cystic liver disease (HP:0006706)1.79761348
145Abnormality of cochlea (HP:0000375)1.78863218
146Abnormality of the phalanges of the 5th finger (HP:0004213)1.76359963
147Focal dystonia (HP:0004373)1.75797777
148Lower limb muscle weakness (HP:0007340)1.75520140
149Sclerocornea (HP:0000647)1.75214041
150Psychosis (HP:0000709)1.75093180
151Asplenia (HP:0001746)1.73530172
152Polydipsia (HP:0001959)1.73316288
153Abnormal drinking behavior (HP:0030082)1.73316288
154Methylmalonic acidemia (HP:0002912)1.73182194
155Morphological abnormality of the inner ear (HP:0011390)1.72169321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.08851545
2NTRK34.42325730
3EPHA43.93619978
4MAP2K73.32677785
5MAP3K43.26237381
6MAP3K123.02957686
7FRK2.90306796
8MARK12.81144396
9MAP3K92.77281719
10MINK12.35518329
11RIPK42.27021024
12DAPK22.18326974
13MAP2K42.12724135
14PLK22.10644838
15GRK11.97305747
16CDK191.96780915
17MAP4K21.87575875
18DAPK11.84094332
19BMPR1B1.80495595
20DYRK21.77305455
21PRPF4B1.76116890
22TAOK31.75350952
23TIE11.74053672
24NTRK21.73693138
25PNCK1.61016402
26SIK31.59890334
27MAPK131.58582367
28AKT31.52831260
29KSR11.49903503
30CCNB11.46351893
31TNIK1.41770298
32PAK61.41457566
33GRK51.37788645
34PRKCG1.29243281
35CDK51.28627372
36BMPR21.27913570
37SIK21.26125363
38TLK11.24377617
39OXSR11.23856832
40BCKDK1.21772095
41MAPKAPK51.21179963
42CAMK2A1.20289023
43TXK1.15822501
44KSR21.15821208
45ZAK1.14830735
46WNK41.14616009
47NME11.10543086
48ARAF1.07525182
49NTRK11.07414781
50SGK21.04222966
51CAMK2B1.00163696
52OBSCN0.98455903
53CAMKK10.96209457
54SGK2230.94154507
55SGK4940.94154507
56INSRR0.93026536
57PTK2B0.92903517
58FES0.92420923
59CAMKK20.90621314
60CSNK1G10.82813540
61PRKCE0.78106143
62CSNK1G30.77763061
63MAP3K130.77460786
64NUAK10.75514588
65PHKG10.75358859
66PHKG20.75358859
67CDK180.75094459
68ACVR1B0.74707486
69SGK10.68604709
70CSNK1G20.68444106
71MAPK150.68355734
72CDK140.67565388
73CDK150.67526807
74FGR0.67413323
75BCR0.66542694
76DYRK1A0.64928481
77STK380.63783281
78UHMK10.63775507
79PIK3CA0.62916408
80LATS20.62364950
81MAP3K60.60983550
82CAMK10.60506726
83CAMK40.60137011
84BRAF0.60024451
85MAP3K20.58995962
86SGK30.57233745
87TSSK60.57215076
88CDK11A0.55763908
89GRK70.55454775
90CAMK2D0.54624800
91CSNK1A10.54450706
92MUSK0.53703228
93RAF10.53435675
94RPS6KA50.53130590
95STK110.52151363
96ADRBK20.51694700
97CSNK1A1L0.51524759
98CAMK2G0.48847625
99PRKG10.48763875
100RET0.48433919
101MAPK120.47567065
102PAK30.47166331
103CDK30.46124798
104WNK30.44721482
105PDK40.44229714
106PDK30.44229714
107FER0.43778553
108PRKCA0.43731040
109PKN10.43660929
110NEK60.42831696
111RPS6KA20.42653740
112TNK20.41459217
113EPHA30.41192091
114VRK10.40999390
115TYRO30.40710927
116PDK10.40127738
117MAP2K10.40074945
118MAP2K20.39339557
119CSNK1D0.38630575
120ADRBK10.38536124
121PDPK10.38195407
122EPHB20.38009717
123MARK20.37865755
124PRKCQ0.37753999
125TRIM280.37335438
126PRKD30.37036311
127PINK10.36807511
128KIT0.36255734
129PRKCZ0.35803775
130TGFBR10.35093855
131PRKCH0.34948138
132PRKACA0.34756093
133FYN0.34443143
134RPS6KA30.33696449
135RPS6KA60.33577934
136ERBB20.33367359
137PRKACG0.32187845
138ERBB30.31441583
139STK390.31023225
140DAPK30.30830364
141MAPK70.30668520

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.58324457
2Synaptic vesicle cycle_Homo sapiens_hsa047213.50198525
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.04685455
4Long-term potentiation_Homo sapiens_hsa047202.82679644
5Circadian entrainment_Homo sapiens_hsa047132.73182429
6GABAergic synapse_Homo sapiens_hsa047272.70630060
7Glutamatergic synapse_Homo sapiens_hsa047242.64389434
8Morphine addiction_Homo sapiens_hsa050322.62629365
9Amphetamine addiction_Homo sapiens_hsa050312.59060926
10Collecting duct acid secretion_Homo sapiens_hsa049662.45380813
11Olfactory transduction_Homo sapiens_hsa047402.40037257
12Salivary secretion_Homo sapiens_hsa049702.21464505
13Dopaminergic synapse_Homo sapiens_hsa047282.20426033
14Taste transduction_Homo sapiens_hsa047422.19656906
15Serotonergic synapse_Homo sapiens_hsa047261.97413964
16Long-term depression_Homo sapiens_hsa047301.95332232
17Insulin secretion_Homo sapiens_hsa049111.84891034
18Renin secretion_Homo sapiens_hsa049241.84670614
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78493995
20Calcium signaling pathway_Homo sapiens_hsa040201.74368055
21Cholinergic synapse_Homo sapiens_hsa047251.74258534
22Gastric acid secretion_Homo sapiens_hsa049711.67735812
23Cocaine addiction_Homo sapiens_hsa050301.60005076
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59056186
25Oxytocin signaling pathway_Homo sapiens_hsa049211.55903511
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53089308
27Nitrogen metabolism_Homo sapiens_hsa009101.44942186
28Vibrio cholerae infection_Homo sapiens_hsa051101.44275431
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44241750
30Oxidative phosphorylation_Homo sapiens_hsa001901.42227932
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38951677
32Linoleic acid metabolism_Homo sapiens_hsa005911.36976753
33Gap junction_Homo sapiens_hsa045401.25437344
34GnRH signaling pathway_Homo sapiens_hsa049121.24714637
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23962615
36Axon guidance_Homo sapiens_hsa043601.22438783
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19127855
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18321249
39cAMP signaling pathway_Homo sapiens_hsa040241.18194456
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17514164
41Cardiac muscle contraction_Homo sapiens_hsa042601.17203680
42Alzheimers disease_Homo sapiens_hsa050101.16757561
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14957431
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08547467
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.07572374
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05276646
47Butanoate metabolism_Homo sapiens_hsa006501.04265591
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99332549
49Ether lipid metabolism_Homo sapiens_hsa005650.98494755
50Estrogen signaling pathway_Homo sapiens_hsa049150.98387139
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98338406
52ErbB signaling pathway_Homo sapiens_hsa040120.98261610
53Phototransduction_Homo sapiens_hsa047440.96669709
54Parkinsons disease_Homo sapiens_hsa050120.95352458
55Melanogenesis_Homo sapiens_hsa049160.92369275
56Type II diabetes mellitus_Homo sapiens_hsa049300.90370708
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.89135693
58Tryptophan metabolism_Homo sapiens_hsa003800.87794681
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86682741
60Glioma_Homo sapiens_hsa052140.84391163
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78787048
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74740602
63Pancreatic secretion_Homo sapiens_hsa049720.74324678
64Oocyte meiosis_Homo sapiens_hsa041140.71668003
65Rheumatoid arthritis_Homo sapiens_hsa053230.71513436
66Protein export_Homo sapiens_hsa030600.71229590
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70871564
68Hedgehog signaling pathway_Homo sapiens_hsa043400.70576163
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68991108
70Huntingtons disease_Homo sapiens_hsa050160.67465901
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65554232
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65502372
73MAPK signaling pathway_Homo sapiens_hsa040100.65110392
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64391156
75Dilated cardiomyopathy_Homo sapiens_hsa054140.63237430
76African trypanosomiasis_Homo sapiens_hsa051430.62090808
77Thyroid hormone synthesis_Homo sapiens_hsa049180.61641374
78Sulfur metabolism_Homo sapiens_hsa009200.58529918
79Choline metabolism in cancer_Homo sapiens_hsa052310.57428222
80Dorso-ventral axis formation_Homo sapiens_hsa043200.57290171
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.56926719
82Ras signaling pathway_Homo sapiens_hsa040140.56843879
83Selenocompound metabolism_Homo sapiens_hsa004500.55877737
84Retinol metabolism_Homo sapiens_hsa008300.55776480
85Regulation of autophagy_Homo sapiens_hsa041400.55593872
86Bile secretion_Homo sapiens_hsa049760.54803084
87Chemical carcinogenesis_Homo sapiens_hsa052040.54476002
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54106412
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.53440730
90Type I diabetes mellitus_Homo sapiens_hsa049400.53428890
91RNA degradation_Homo sapiens_hsa030180.50334873
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49545837
93Glucagon signaling pathway_Homo sapiens_hsa049220.49402499
94Basal cell carcinoma_Homo sapiens_hsa052170.47703338
95Glycerolipid metabolism_Homo sapiens_hsa005610.46019457
96Circadian rhythm_Homo sapiens_hsa047100.44555281
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44460037
98Basal transcription factors_Homo sapiens_hsa030220.44246140
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43688501
100Ribosome_Homo sapiens_hsa030100.43471859
101Alcoholism_Homo sapiens_hsa050340.42930894
102Rap1 signaling pathway_Homo sapiens_hsa040150.42571876
103Inositol phosphate metabolism_Homo sapiens_hsa005620.42421303
104Phagosome_Homo sapiens_hsa041450.41947636
105ABC transporters_Homo sapiens_hsa020100.40223185
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39353064
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39332653
108Wnt signaling pathway_Homo sapiens_hsa043100.39090702
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38844031
110Sulfur relay system_Homo sapiens_hsa041220.38088197
111Fatty acid biosynthesis_Homo sapiens_hsa000610.37912556
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.36669458
113Peroxisome_Homo sapiens_hsa041460.36440372
114Arachidonic acid metabolism_Homo sapiens_hsa005900.35206297
115VEGF signaling pathway_Homo sapiens_hsa043700.34956188
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34009420
117Histidine metabolism_Homo sapiens_hsa003400.33765413
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.33685682
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33400369
120Caffeine metabolism_Homo sapiens_hsa002320.33350142
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32742593
122Ovarian steroidogenesis_Homo sapiens_hsa049130.32575209
123Mineral absorption_Homo sapiens_hsa049780.32385903
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29002040
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28365710
126Renal cell carcinoma_Homo sapiens_hsa052110.26154828
127Melanoma_Homo sapiens_hsa052180.25811014
128Prion diseases_Homo sapiens_hsa050200.25454737
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24452234
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24140086
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23597956
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20955990
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20914696
134Insulin signaling pathway_Homo sapiens_hsa049100.20577547
135Endometrial cancer_Homo sapiens_hsa052130.18351547
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17881543

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