SLITRK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Slitrk family of structurally related transmembrane proteins that are involved in controlling neurite outgrowth. The encoded protein contains two leucine-rich repeat (LRR) domains and a C-terminal domain that is partially similar to Trk neurotrophin receptor protein. Enhanced expression of this gene was found in tissue from several different types of tumors. Alternative splicing results in multiple transcript variants, all encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.03062007
2vocalization behavior (GO:0071625)5.65790439
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.59935883
4pyrimidine nucleobase catabolic process (GO:0006208)5.53279511
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.39642811
6locomotory exploration behavior (GO:0035641)5.27782401
7synaptic vesicle exocytosis (GO:0016079)5.25931954
8neuron cell-cell adhesion (GO:0007158)5.20155224
9synaptic vesicle maturation (GO:0016188)5.10056966
10ionotropic glutamate receptor signaling pathway (GO:0035235)5.08526961
11regulation of glutamate receptor signaling pathway (GO:1900449)5.02958438
12protein localization to synapse (GO:0035418)5.02730973
13glutamate secretion (GO:0014047)4.92250093
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.86584385
15glutamate receptor signaling pathway (GO:0007215)4.73392567
16neuronal action potential propagation (GO:0019227)4.68883523
17regulation of synaptic vesicle exocytosis (GO:2000300)4.64351751
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.59366232
19synaptic transmission, glutamatergic (GO:0035249)4.51793487
20exploration behavior (GO:0035640)4.47091080
21nucleobase catabolic process (GO:0046113)4.47046329
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.39700514
23neuron-neuron synaptic transmission (GO:0007270)4.39079241
24regulation of neuronal synaptic plasticity (GO:0048168)4.34367087
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.33680090
26neurotransmitter-gated ion channel clustering (GO:0072578)4.22507082
27regulation of synaptic vesicle transport (GO:1902803)4.19672031
28neurotransmitter secretion (GO:0007269)4.12555282
29long-term memory (GO:0007616)4.00624915
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.00395548
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.99785966
32positive regulation of synapse maturation (GO:0090129)3.96526814
33regulation of synapse structural plasticity (GO:0051823)3.95731882
34presynaptic membrane assembly (GO:0097105)3.94059139
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.94020914
36neuron recognition (GO:0008038)3.91885455
37cellular potassium ion homeostasis (GO:0030007)3.86549871
38regulation of postsynaptic membrane potential (GO:0060078)3.84061358
39positive regulation of membrane potential (GO:0045838)3.83287860
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.81056639
41establishment of mitochondrion localization (GO:0051654)3.79918319
42neurofilament cytoskeleton organization (GO:0060052)3.75654946
43transmission of nerve impulse (GO:0019226)3.73759886
44cell migration in hindbrain (GO:0021535)3.72498980
45presynaptic membrane organization (GO:0097090)3.70685176
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67367777
47regulation of synaptic plasticity (GO:0048167)3.65358807
48long-term synaptic potentiation (GO:0060291)3.64843868
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.64177708
50positive regulation of synapse assembly (GO:0051965)3.64142718
51layer formation in cerebral cortex (GO:0021819)3.63886940
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62243009
53response to histamine (GO:0034776)3.61908675
54behavioral defense response (GO:0002209)3.61748036
55behavioral fear response (GO:0001662)3.61748036
56negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.60261720
57dendritic spine morphogenesis (GO:0060997)3.58743143
58regulation of dendritic spine morphogenesis (GO:0061001)3.56235967
59L-amino acid import (GO:0043092)3.53186037
60axonal fasciculation (GO:0007413)3.52513600
61gamma-aminobutyric acid transport (GO:0015812)3.52479876
62postsynaptic membrane organization (GO:0001941)3.51744892
63synaptic vesicle endocytosis (GO:0048488)3.45558456
64neurotransmitter transport (GO:0006836)3.42675388
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.42422313
66neuromuscular synaptic transmission (GO:0007274)3.40045548
67innervation (GO:0060384)3.39133231
68righting reflex (GO:0060013)3.37819496
69amino acid import (GO:0043090)3.36819745
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36599262
71fear response (GO:0042596)3.32158564
72proline transport (GO:0015824)3.31280865
73membrane hyperpolarization (GO:0060081)3.30972104
74central nervous system projection neuron axonogenesis (GO:0021952)3.25813167
75membrane depolarization (GO:0051899)3.24483220
76regulation of neurotransmitter secretion (GO:0046928)3.22964877
77cerebellar Purkinje cell differentiation (GO:0021702)3.22100797
78learning (GO:0007612)3.20741245
79regulation of vesicle fusion (GO:0031338)3.18956786
80startle response (GO:0001964)3.18878914
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18814007
82regulation of synapse maturation (GO:0090128)3.18374528
83regulation of neurotransmitter levels (GO:0001505)3.15151344
84G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.14785279
85synapse organization (GO:0050808)3.14566849
86C4-dicarboxylate transport (GO:0015740)3.10030854
87cerebellar granule cell differentiation (GO:0021707)3.09899993
88regulation of dendritic spine development (GO:0060998)3.09334480
89mechanosensory behavior (GO:0007638)3.07666183
90synapse assembly (GO:0007416)3.07575025
91activation of protein kinase A activity (GO:0034199)3.06997199
92synaptic transmission (GO:0007268)3.06270331
93neuromuscular process controlling balance (GO:0050885)3.06247021
94membrane depolarization during action potential (GO:0086010)3.05582979
95positive regulation of dendritic spine morphogenesis (GO:0061003)3.05403470
96regulation of synaptic transmission (GO:0050804)3.04364075
97positive regulation of action potential (GO:0045760)3.03691530
98positive regulation of dendritic spine development (GO:0060999)3.03601328
99response to auditory stimulus (GO:0010996)3.03088079
100positive regulation of synaptic transmission (GO:0050806)3.03087545
101neuromuscular process controlling posture (GO:0050884)3.02379668
102acidic amino acid transport (GO:0015800)3.01988142
103regulation of neurotransmitter transport (GO:0051588)3.01544215
104potassium ion import (GO:0010107)3.00736473
105cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00535532
106positive regulation of neurotransmitter transport (GO:0051590)3.00018043
107sodium ion export (GO:0071436)2.99994911
108long term synaptic depression (GO:0060292)2.99689860
109neuronal ion channel clustering (GO:0045161)2.99038140
110neurotransmitter uptake (GO:0001504)2.98935820
111positive regulation of neurotransmitter secretion (GO:0001956)2.98583592
112regulation of glutamate secretion (GO:0014048)2.98510210
113dendrite morphogenesis (GO:0048813)2.96266678
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93312693
115auditory behavior (GO:0031223)2.90861986
116regulation of synaptic transmission, GABAergic (GO:0032228)2.90043966
117adult walking behavior (GO:0007628)2.89587761
118glycosphingolipid biosynthetic process (GO:0006688)2.88564203
119behavioral response to cocaine (GO:0048148)2.87422576
120regulation of synapse assembly (GO:0051963)2.86988200
121behavioral response to nicotine (GO:0035095)2.84774558
122cellular sodium ion homeostasis (GO:0006883)2.83403555
123adult behavior (GO:0030534)2.83270277
124regulation of respiratory system process (GO:0044065)2.81609064
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79507914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94560806
2GBX2_23144817_ChIP-Seq_PC3_Human4.10184840
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17905954
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16722300
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08367660
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71529644
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71529644
8REST_21632747_ChIP-Seq_MESCs_Mouse2.67125594
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66150501
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63970101
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56557564
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.50129928
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47276672
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47207696
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45599405
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.37482771
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.34985594
18DROSHA_22980978_ChIP-Seq_HELA_Human2.30644941
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.21287455
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20987877
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.15450094
22TAF15_26573619_Chip-Seq_HEK293_Human2.15362892
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.12860935
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11462363
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06053525
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98769651
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97056349
28AR_21572438_ChIP-Seq_LNCaP_Human1.96313813
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93809898
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93527592
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84294575
32SMAD4_21799915_ChIP-Seq_A2780_Human1.77207218
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76163767
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75229793
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73493739
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63533391
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61375931
38* P300_19829295_ChIP-Seq_ESCs_Human1.60314970
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55915820
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50335332
41* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45230201
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.44868698
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.44789988
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.42674019
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41110063
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41003304
47* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38459505
48* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37312516
49AR_25329375_ChIP-Seq_VCAP_Human1.35208497
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34776149
51IGF1R_20145208_ChIP-Seq_DFB_Human1.34062470
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33482045
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32160320
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.31993209
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31584302
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31384478
57ZNF274_21170338_ChIP-Seq_K562_Hela1.30410144
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.29541067
59STAT3_23295773_ChIP-Seq_U87_Human1.29458102
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.29168473
61FUS_26573619_Chip-Seq_HEK293_Human1.25989804
62EWS_26573619_Chip-Seq_HEK293_Human1.25723638
63* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25244354
64* RING1B_27294783_Chip-Seq_ESCs_Mouse1.24479391
65RNF2_27304074_Chip-Seq_NSC_Mouse1.22135554
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21538402
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19933657
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18153493
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.17819243
70AR_19668381_ChIP-Seq_PC3_Human1.17146943
71VDR_22108803_ChIP-Seq_LS180_Human1.16442280
72TCF4_23295773_ChIP-Seq_U87_Human1.15497818
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12724441
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.11042369
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10754536
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10547198
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08604091
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08582821
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08172028
80* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07661838
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06171386
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.05884255
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.05847694
84ER_23166858_ChIP-Seq_MCF-7_Human1.04666799
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04599743
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04527695
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03795271
88RUNX2_22187159_ChIP-Seq_PCA_Human1.02969001
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02786995
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02480263
91CBP_20019798_ChIP-Seq_JUKART_Human1.02480263
92* SOX9_26525672_Chip-Seq_HEART_Mouse1.02396213
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02299012
94JUN_21703547_ChIP-Seq_K562_Human1.01114205
95AHR_22903824_ChIP-Seq_MCF-7_Human1.00876335
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00432628
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99933620
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99849097
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99849097
100* TAL1_26923725_Chip-Seq_HPCs_Mouse0.99789757
101TP53_16413492_ChIP-PET_HCT116_Human0.99656405
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98619911
103* KDM2B_26808549_Chip-Seq_REH_Human0.98395026
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98112123
105* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97351653
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96576826
107GATA1_26923725_Chip-Seq_HPCs_Mouse0.96151804
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95973575
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95436173
110TP53_18474530_ChIP-ChIP_U2OS_Human0.95081719
111* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94779488
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94396387
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.93052688
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91022065
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90774350
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.89817254
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.89591726
118BCAT_22108803_ChIP-Seq_LS180_Human0.89400587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.46404531
2MP0003880_abnormal_central_pattern5.38238094
3MP0003635_abnormal_synaptic_transmissio4.15793079
4MP0004270_analgesia3.66711349
5MP0009745_abnormal_behavioral_response3.54723625
6MP0002063_abnormal_learning/memory/cond3.38949319
7MP0002064_seizures3.25308302
8MP0001968_abnormal_touch/_nociception3.13430788
9MP0009046_muscle_twitch3.09357950
10MP0002572_abnormal_emotion/affect_behav2.87438089
11MP0002272_abnormal_nervous_system2.79345102
12MP0002735_abnormal_chemical_nociception2.67377726
13MP0002822_catalepsy2.65743070
14MP0005423_abnormal_somatic_nervous2.64520456
15MP0001486_abnormal_startle_reflex2.62632899
16MP0002734_abnormal_mechanical_nocicepti2.57534958
17MP0002736_abnormal_nociception_after2.54645012
18MP0001501_abnormal_sleep_pattern2.33509109
19MP0001440_abnormal_grooming_behavior2.16853475
20MP0002067_abnormal_sensory_capabilities2.09288014
21MP0002733_abnormal_thermal_nociception1.98469851
22MP0001970_abnormal_pain_threshold1.95252391
23MP0002184_abnormal_innervation1.87826209
24MP0000778_abnormal_nervous_system1.86012162
25MP0006276_abnormal_autonomic_nervous1.83371475
26MP0003329_amyloid_beta_deposits1.82973429
27MP0001529_abnormal_vocalization1.75165682
28MP0008569_lethality_at_weaning1.73901360
29MP0002557_abnormal_social/conspecific_i1.71842681
30MP0004858_abnormal_nervous_system1.70949161
31MP0003879_abnormal_hair_cell1.70586869
32MP0005386_behavior/neurological_phenoty1.70132516
33MP0004924_abnormal_behavior1.70132516
34MP0004811_abnormal_neuron_physiology1.66935851
35MP0009780_abnormal_chondrocyte_physiolo1.61866629
36MP0001984_abnormal_olfaction1.60667685
37MP0005646_abnormal_pituitary_gland1.55963049
38MP0002909_abnormal_adrenal_gland1.54409019
39MP0000955_abnormal_spinal_cord1.53558790
40MP0001188_hyperpigmentation1.52424654
41MP0002882_abnormal_neuron_morphology1.45906073
42MP0002066_abnormal_motor_capabilities/c1.42418847
43MP0003787_abnormal_imprinting1.41826990
44MP0001905_abnormal_dopamine_level1.39577188
45MP0004885_abnormal_endolymph1.38391090
46MP0003136_yellow_coat_color1.38253675
47MP0008877_abnormal_DNA_methylation1.37502835
48MP0004142_abnormal_muscle_tone1.34483504
49MP0003633_abnormal_nervous_system1.29077807
50MP0001502_abnormal_circadian_rhythm1.26507532
51MP0005645_abnormal_hypothalamus_physiol1.24901909
52MP0003121_genomic_imprinting1.23300733
53MP0005551_abnormal_eye_electrophysiolog1.21571235
54MP0004147_increased_porphyrin_level1.18987300
55MP0001986_abnormal_taste_sensitivity1.17715170
56MP0010386_abnormal_urinary_bladder1.15864671
57MP0005187_abnormal_penis_morphology1.15725599
58MP0003631_nervous_system_phenotype1.12598062
59MP0003122_maternal_imprinting1.11125907
60MP0002102_abnormal_ear_morphology1.10265288
61MP0002229_neurodegeneration1.09947837
62MP0002653_abnormal_ependyma_morphology1.06483956
63MP0002152_abnormal_brain_morphology1.06384118
64MP0003283_abnormal_digestive_organ1.05079086
65MP0005253_abnormal_eye_physiology0.99509973
66MP0001963_abnormal_hearing_physiology0.97894847
67MP0004742_abnormal_vestibular_system0.96702820
68MP0000920_abnormal_myelination0.96303169
69MP0000751_myopathy0.95263610
70MP0002234_abnormal_pharynx_morphology0.94758193
71MP0005409_darkened_coat_color0.94747438
72MP0002751_abnormal_autonomic_nervous0.93251288
73MP0008872_abnormal_physiological_respon0.92732095
74MP0008874_decreased_physiological_sensi0.92537859
75MP0002069_abnormal_eating/drinking_beha0.92403861
76MP0004133_heterotaxia0.90946249
77MP0003634_abnormal_glial_cell0.89166916
78MP0004145_abnormal_muscle_electrophysio0.88411580
79MP0002752_abnormal_somatic_nervous0.88246046
80MP0004085_abnormal_heartbeat0.85429189
81MP0001177_atelectasis0.83836342
82MP0005171_absent_coat_pigmentation0.82154968
83MP0002090_abnormal_vision0.81599607
84MP0003632_abnormal_nervous_system0.81205171
85MP0000604_amyloidosis0.80227434
86MP0005535_abnormal_body_temperature0.77339470
87MP0003119_abnormal_digestive_system0.76991737
88MP0002876_abnormal_thyroid_physiology0.76070578
89MP0005499_abnormal_olfactory_system0.73931551
90MP0005394_taste/olfaction_phenotype0.73931551
91MP0002837_dystrophic_cardiac_calcinosis0.73891549
92MP0001485_abnormal_pinna_reflex0.73665204
93MP0001664_abnormal_digestion0.73183695
94MP0003690_abnormal_glial_cell0.73077919
95MP0004043_abnormal_pH_regulation0.73063042
96MP0000631_abnormal_neuroendocrine_gland0.72653322
97MP0003075_altered_response_to0.65789790
98MP0003011_delayed_dark_adaptation0.65618573
99MP0005167_abnormal_blood-brain_barrier0.64526242
100MP0004215_abnormal_myocardial_fiber0.64270594
101MP0002638_abnormal_pupillary_reflex0.64068082
102MP0004233_abnormal_muscle_weight0.61440993
103MP0000026_abnormal_inner_ear0.61246135
104MP0004484_altered_response_of0.60506286
105MP0003938_abnormal_ear_development0.59724444
106MP0004510_myositis0.57269099
107MP0001943_abnormal_respiration0.55948573
108MP0006072_abnormal_retinal_apoptosis0.55371932
109MP0003890_abnormal_embryonic-extraembry0.55243252
110MP0003137_abnormal_impulse_conducting0.54899030
111MP0003861_abnormal_nervous_system0.52043065
112MP0010769_abnormal_survival0.51988429
113MP0002082_postnatal_lethality0.51357772
114MP0010770_preweaning_lethality0.51357772
115MP0000569_abnormal_digit_pigmentation0.49864731
116MP0005623_abnormal_meninges_morphology0.49747509
117MP0001299_abnormal_eye_distance/0.48882097
118MP0010768_mortality/aging0.48737163
119MP0003956_abnormal_body_size0.48734650

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.63797752
2Myokymia (HP:0002411)6.69700210
3Focal seizures (HP:0007359)5.95258054
4Epileptic encephalopathy (HP:0200134)5.41971350
5Atonic seizures (HP:0010819)5.17668429
6Febrile seizures (HP:0002373)4.99914449
7Visual hallucinations (HP:0002367)4.72620041
8Absence seizures (HP:0002121)4.69525342
9Progressive cerebellar ataxia (HP:0002073)4.38649317
10Dialeptic seizures (HP:0011146)4.37939758
11Hyperventilation (HP:0002883)4.18122782
12Generalized tonic-clonic seizures (HP:0002069)4.05483795
13Broad-based gait (HP:0002136)3.66844276
14Supranuclear gaze palsy (HP:0000605)3.58060964
15Ulnar claw (HP:0001178)3.51512845
16Gaze-evoked nystagmus (HP:0000640)3.50622472
17Action tremor (HP:0002345)3.50471495
18Ankle clonus (HP:0011448)3.22128340
19Amyotrophic lateral sclerosis (HP:0007354)3.21939229
20Impaired vibration sensation in the lower limbs (HP:0002166)3.21585929
21Dysmetria (HP:0001310)3.19232036
22Dysdiadochokinesis (HP:0002075)3.14795220
23Truncal ataxia (HP:0002078)3.11487553
24Poor eye contact (HP:0000817)3.06747646
25Urinary bladder sphincter dysfunction (HP:0002839)3.02087638
26Depression (HP:0000716)3.01663417
27Peripheral hypomyelination (HP:0007182)3.01087241
28Amblyopia (HP:0000646)3.00889277
29Drooling (HP:0002307)2.91423049
30Excessive salivation (HP:0003781)2.91423049
31Abnormal eating behavior (HP:0100738)2.90738041
32Anxiety (HP:0000739)2.87633873
33Abnormal social behavior (HP:0012433)2.85193431
34Impaired social interactions (HP:0000735)2.85193431
35Scanning speech (HP:0002168)2.81687902
36Absent speech (HP:0001344)2.80501649
37Neurofibrillary tangles (HP:0002185)2.76519179
38Postural instability (HP:0002172)2.75157077
39Epileptiform EEG discharges (HP:0011182)2.74619234
40Mutism (HP:0002300)2.73467289
41Morphological abnormality of the pyramidal tract (HP:0002062)2.72403987
42Lissencephaly (HP:0001339)2.71884843
43Cerebral inclusion bodies (HP:0100314)2.71536401
44Spastic gait (HP:0002064)2.71524631
45Progressive inability to walk (HP:0002505)2.65174532
46Urinary urgency (HP:0000012)2.65067262
47Genetic anticipation (HP:0003743)2.62174264
48Insidious onset (HP:0003587)2.61836947
49Termporal pattern (HP:0011008)2.61836947
50Spastic tetraplegia (HP:0002510)2.55346810
51Diplopia (HP:0000651)2.54540194
52Abnormality of binocular vision (HP:0011514)2.54540194
53Hemiparesis (HP:0001269)2.53826565
54EEG with generalized epileptiform discharges (HP:0011198)2.53100561
55Impaired smooth pursuit (HP:0007772)2.52448208
56Congenital primary aphakia (HP:0007707)2.50776928
57Abnormality of the corticospinal tract (HP:0002492)2.46841919
58Pheochromocytoma (HP:0002666)2.45809372
59Fetal akinesia sequence (HP:0001989)2.44086144
60Bradykinesia (HP:0002067)2.42245573
61Poor suck (HP:0002033)2.41458320
62Nephrogenic diabetes insipidus (HP:0009806)2.40807605
63Torticollis (HP:0000473)2.40716398
64Inability to walk (HP:0002540)2.38424448
65Medial flaring of the eyebrow (HP:0010747)2.34405517
66Sleep apnea (HP:0010535)2.34326886
67Stereotypic behavior (HP:0000733)2.32557138
68Genital tract atresia (HP:0001827)2.30786034
69Abnormality of the labia minora (HP:0012880)2.29066005
70Vaginal atresia (HP:0000148)2.28941645
71Focal dystonia (HP:0004373)2.28016932
72Abnormality of the lower motor neuron (HP:0002366)2.27436609
73Polyphagia (HP:0002591)2.26358572
74Intention tremor (HP:0002080)2.24764470
75Retinal dysplasia (HP:0007973)2.23694033
76Hypsarrhythmia (HP:0002521)2.23230618
77Abnormality of ocular smooth pursuit (HP:0000617)2.19336260
78Impaired vibratory sensation (HP:0002495)2.19018002
79Generalized myoclonic seizures (HP:0002123)2.17751772
80Neuroendocrine neoplasm (HP:0100634)2.17291029
81Blue irides (HP:0000635)2.17163089
82Pachygyria (HP:0001302)2.16844057
83Limb dystonia (HP:0002451)2.16567748
84Lower limb muscle weakness (HP:0007340)2.15984386
85Status epilepticus (HP:0002133)2.14129835
86Dysmetric saccades (HP:0000641)2.09571152
87Papilledema (HP:0001085)2.09198563
88Degeneration of the lateral corticospinal tracts (HP:0002314)2.08668378
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08668378
90Poor coordination (HP:0002370)2.05719616
91Hypoplasia of the corpus callosum (HP:0002079)2.03900466
92Abnormality of salivation (HP:0100755)2.02354878
93Thickened helices (HP:0000391)2.02325661
94Protruding tongue (HP:0010808)2.02323859
95Incomplete penetrance (HP:0003829)2.01367662
96Craniofacial dystonia (HP:0012179)1.99607848
97Cerebral hypomyelination (HP:0006808)1.99199211
98Optic nerve hypoplasia (HP:0000609)1.98142154
99Gait imbalance (HP:0002141)1.95566339
100Thyroid-stimulating hormone excess (HP:0002925)1.95498161
101Gait ataxia (HP:0002066)1.93904927
102Hemiplegia (HP:0002301)1.93762745
103Split foot (HP:0001839)1.93551093
104Megalencephaly (HP:0001355)1.87610893
105Muscular hypotonia of the trunk (HP:0008936)1.87558462
106Atrophy/Degeneration involving motor neurons (HP:0007373)1.84600923
107Hypoplasia of the brainstem (HP:0002365)1.84282888
108Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84282888
109Akinesia (HP:0002304)1.83494580
110Delusions (HP:0000746)1.83203480
111Failure to thrive in infancy (HP:0001531)1.83020299
112Ventricular fibrillation (HP:0001663)1.80383111
113Type II lissencephaly (HP:0007260)1.79987547
114Intellectual disability, severe (HP:0010864)1.78244701
115Specific learning disability (HP:0001328)1.77892265
116Psychosis (HP:0000709)1.77355254
117Neuronal loss in central nervous system (HP:0002529)1.76794777
118Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76309469
119Esotropia (HP:0000565)1.75453845
120Cerebellar dysplasia (HP:0007033)1.74183588
121Dynein arm defect of respiratory motile cilia (HP:0012255)1.73461255
122Absent/shortened dynein arms (HP:0200106)1.73461255
123Widely spaced teeth (HP:0000687)1.72188381
124Abnormality of saccadic eye movements (HP:0000570)1.71308032
125Agitation (HP:0000713)1.70806385
126Rigidity (HP:0002063)1.69929799
127Annular pancreas (HP:0001734)1.68856959
128Clonus (HP:0002169)1.68703072
129Paraplegia (HP:0010550)1.66686209
130Cortical dysplasia (HP:0002539)1.66566947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.75192310
2EPHA44.56256176
3MAP3K93.61568925
4CASK3.11932400
5MAP3K42.92851621
6MARK12.82907762
7MAP2K72.63633013
8MINK12.62289611
9RIPK42.05581762
10DAPK22.05541758
11KSR22.01893118
12MAP3K121.98146300
13NTRK21.96693464
14PAK61.96506005
15PRPF4B1.78042293
16TRIM281.75553725
17MAP2K41.75136728
18EPHA31.74362894
19DYRK21.74350272
20KSR11.71387370
21TNIK1.70036721
22PLK21.64814332
23ARAF1.63266211
24NTRK11.63113161
25DAPK11.56748376
26PNCK1.53826503
27CDK51.51237606
28PRKD31.50443305
29MAPK131.45654202
30MAP3K131.44800751
31CDK191.43718189
32CAMKK11.40709795
33MAP4K21.37987745
34FES1.37195181
35GRK51.36122533
36CSNK1A1L1.29944380
37PRKCG1.27220424
38SIK21.23603828
39CSNK1G31.20184810
40CAMK2A1.16158550
41CAMK2B1.10421179
42OXSR11.08244588
43FRK1.05279540
44STK381.04706272
45MAP3K21.02693228
46UHMK11.01214071
47CSNK1G10.97093282
48SGK4940.95228543
49SGK2230.95228543
50PTK2B0.94437137
51TYRO30.91813929
52NME10.91323175
53CAMK10.91308319
54PHKG20.89978720
55PHKG10.89978720
56CDK180.87925169
57RAF10.86637099
58CDK140.86218540
59BMPR20.84506879
60CAMKK20.84242328
61CDK150.84184200
62ERBB30.79645953
63DYRK1A0.78652981
64SGK20.77245267
65CAMK1D0.74832291
66STK110.74245749
67CDK11A0.72672198
68STK390.70799173
69CSNK1G20.68724020
70MARK20.68467266
71FGR0.68439186
72SGK10.67392378
73PRKCE0.66502868
74SIK30.65844330
75LATS20.65595087
76PAK30.65573515
77CAMK2D0.65347066
78NEK60.64773677
79ADRBK20.64047440
80GRK10.63049888
81PRKCH0.61209026
82PDK10.60602478
83AKT30.60094349
84RET0.59932949
85MKNK20.59550249
86BCR0.58730469
87LMTK20.57320052
88PINK10.56539365
89PDPK10.55117680
90SGK30.54590094
91TAOK10.54220219
92FER0.53829974
93CAMK2G0.53039923
94BRAF0.52380953
95PRKCZ0.51482724
96GRK70.50581547
97BMPR1B0.50530531
98CSNK1A10.50178114
99TNK20.50120165
100MAP3K10.48885306
101CAMK1G0.46105515
102CSNK1D0.46063888
103LIMK10.46044856
104WNK10.45032247
105CDK30.44291269
106MAP3K70.43850724
107RPS6KA30.43794145
108MUSK0.43755085
109ROCK20.43199338
110PRKACA0.42771148
111MAP2K10.42692229
112MAPK100.42638800
113FYN0.42194089
114CSNK1E0.41693881
115PKN10.39827032
116DMPK0.39207928
117WNK30.39108504
118PRKACB0.38422431
119ALK0.37655446
120CCNB10.34214494
121INSRR0.34065787
122PRKCB0.34065473
123STK38L0.33602408
124PRKG10.33564562
125CAMK40.33363731
126MAP3K60.33003755
127TAOK30.32666184
128MAPKAPK50.31323452
129PRKAA10.30631132
130TSSK60.30111294
131PRKCA0.29996310
132ERBB20.29488290
133MAPK120.28550977
134DYRK30.28042635

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.21252149
2Synaptic vesicle cycle_Homo sapiens_hsa047213.29170663
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.91176834
4GABAergic synapse_Homo sapiens_hsa047272.83544071
5Circadian entrainment_Homo sapiens_hsa047132.78155005
6Long-term potentiation_Homo sapiens_hsa047202.73638892
7Glutamatergic synapse_Homo sapiens_hsa047242.71094979
8Olfactory transduction_Homo sapiens_hsa047402.67636547
9Morphine addiction_Homo sapiens_hsa050322.64276459
10Amphetamine addiction_Homo sapiens_hsa050312.44266810
11Salivary secretion_Homo sapiens_hsa049702.28139552
12Dopaminergic synapse_Homo sapiens_hsa047282.17133923
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08115454
14Taste transduction_Homo sapiens_hsa047422.01371023
15Insulin secretion_Homo sapiens_hsa049111.97164997
16Cholinergic synapse_Homo sapiens_hsa047251.90655028
17Long-term depression_Homo sapiens_hsa047301.82047182
18Serotonergic synapse_Homo sapiens_hsa047261.81648625
19Gastric acid secretion_Homo sapiens_hsa049711.79096306
20Collecting duct acid secretion_Homo sapiens_hsa049661.77893164
21Renin secretion_Homo sapiens_hsa049241.73204630
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72345467
23Calcium signaling pathway_Homo sapiens_hsa040201.69900715
24Oxytocin signaling pathway_Homo sapiens_hsa049211.65443893
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58211417
26Cocaine addiction_Homo sapiens_hsa050301.54562885
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36984944
28GnRH signaling pathway_Homo sapiens_hsa049121.36230483
29Gap junction_Homo sapiens_hsa045401.34186330
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32867689
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32803215
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32678832
33cAMP signaling pathway_Homo sapiens_hsa040241.26902711
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26703360
35Axon guidance_Homo sapiens_hsa043601.24838247
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20977188
37Vibrio cholerae infection_Homo sapiens_hsa051101.11333915
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08085227
39Cardiac muscle contraction_Homo sapiens_hsa042601.07801040
40Phototransduction_Homo sapiens_hsa047441.05585775
41Glioma_Homo sapiens_hsa052141.02834117
42ErbB signaling pathway_Homo sapiens_hsa040121.02825597
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02387423
44Estrogen signaling pathway_Homo sapiens_hsa049151.02117455
45Type II diabetes mellitus_Homo sapiens_hsa049301.00040555
46Melanogenesis_Homo sapiens_hsa049160.99163799
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.98782794
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96328472
49Butanoate metabolism_Homo sapiens_hsa006500.90885683
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90032584
51Pancreatic secretion_Homo sapiens_hsa049720.85915986
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85735927
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85088553
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82482623
55Dorso-ventral axis formation_Homo sapiens_hsa043200.82305424
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82134155
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.81431164
58Histidine metabolism_Homo sapiens_hsa003400.77173481
59Oocyte meiosis_Homo sapiens_hsa041140.77095967
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75886081
61Choline metabolism in cancer_Homo sapiens_hsa052310.72577071
62beta-Alanine metabolism_Homo sapiens_hsa004100.71623523
63Ether lipid metabolism_Homo sapiens_hsa005650.71394663
64Thyroid hormone synthesis_Homo sapiens_hsa049180.69719679
65MAPK signaling pathway_Homo sapiens_hsa040100.69039716
66Dilated cardiomyopathy_Homo sapiens_hsa054140.68944953
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64044562
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63529602
69Ras signaling pathway_Homo sapiens_hsa040140.61503072
70Alzheimers disease_Homo sapiens_hsa050100.61225969
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56057824
72Arginine and proline metabolism_Homo sapiens_hsa003300.56003715
73Mineral absorption_Homo sapiens_hsa049780.55989693
74Rap1 signaling pathway_Homo sapiens_hsa040150.53509790
75VEGF signaling pathway_Homo sapiens_hsa043700.52286229
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52147558
77Oxidative phosphorylation_Homo sapiens_hsa001900.51548353
78Alcoholism_Homo sapiens_hsa050340.49714472
79Regulation of autophagy_Homo sapiens_hsa041400.49062301
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48984658
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.48708584
82African trypanosomiasis_Homo sapiens_hsa051430.48665044
83Hippo signaling pathway_Homo sapiens_hsa043900.48380445
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48302896
85Linoleic acid metabolism_Homo sapiens_hsa005910.47163267
86Inositol phosphate metabolism_Homo sapiens_hsa005620.46871091
87Glucagon signaling pathway_Homo sapiens_hsa049220.46640432
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46025561
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.45852025
90Fatty acid biosynthesis_Homo sapiens_hsa000610.45752358
91Arginine biosynthesis_Homo sapiens_hsa002200.45533591
92Protein export_Homo sapiens_hsa030600.45417358
93Circadian rhythm_Homo sapiens_hsa047100.44665364
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43712145
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43642471
96Type I diabetes mellitus_Homo sapiens_hsa049400.43605205
97Prion diseases_Homo sapiens_hsa050200.42889745
98Phenylalanine metabolism_Homo sapiens_hsa003600.42810791
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.41163990
100Wnt signaling pathway_Homo sapiens_hsa043100.41014687
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40699007
102Propanoate metabolism_Homo sapiens_hsa006400.40572016
103Endocytosis_Homo sapiens_hsa041440.39893368
104Nitrogen metabolism_Homo sapiens_hsa009100.38797868
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37479361
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37088802
107Rheumatoid arthritis_Homo sapiens_hsa053230.35624294
108Ovarian steroidogenesis_Homo sapiens_hsa049130.35105231
109Tight junction_Homo sapiens_hsa045300.34929417
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34876016
111mTOR signaling pathway_Homo sapiens_hsa041500.33307877
112Renal cell carcinoma_Homo sapiens_hsa052110.33215148
113Bile secretion_Homo sapiens_hsa049760.32985182
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30306796
115Parkinsons disease_Homo sapiens_hsa050120.28944508
116Chemokine signaling pathway_Homo sapiens_hsa040620.28239628
117Non-small cell lung cancer_Homo sapiens_hsa052230.28141885
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26187900
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26138036
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25415022
121Endometrial cancer_Homo sapiens_hsa052130.25218491
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25046047
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24928156
124Insulin signaling pathway_Homo sapiens_hsa049100.24541978

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