SLFN13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.76329515
2cilium or flagellum-dependent cell motility (GO:0001539)9.72654174
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.96544660
4cilium movement (GO:0003341)7.64817654
5motile cilium assembly (GO:0044458)6.97739988
6epithelial cilium movement (GO:0003351)6.37683851
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.54224741
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.53902201
9antigen processing and presentation of endogenous antigen (GO:0019883)5.16119126
10tolerance induction (GO:0002507)5.12906090
11axoneme assembly (GO:0035082)5.11770054
12positive regulation of gamma-delta T cell activation (GO:0046645)4.95046685
13leukocyte aggregation (GO:0070486)4.76112255
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55977464
15regulation of B cell receptor signaling pathway (GO:0050855)4.51579241
16regulation of gamma-delta T cell differentiation (GO:0045586)4.32125944
17regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.30885883
18regulation of gamma-delta T cell activation (GO:0046643)4.28568764
19negative thymic T cell selection (GO:0045060)4.25023413
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.24911795
21negative regulation of cell killing (GO:0031342)4.24911795
22negative T cell selection (GO:0043383)4.20407991
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.17620908
24regulation of germinal center formation (GO:0002634)4.09225532
25T cell migration (GO:0072678)3.90999306
26B cell receptor signaling pathway (GO:0050853)3.67924940
27cellular response to interleukin-15 (GO:0071350)3.64580819
28positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.52276204
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.51565110
30positive regulation of tolerance induction (GO:0002645)3.49357401
31regulation of cilium movement (GO:0003352)3.49305867
32response to interleukin-15 (GO:0070672)3.43970259
33regulation of alpha-beta T cell proliferation (GO:0046640)3.39761175
34left/right axis specification (GO:0070986)3.37595529
35response to type I interferon (GO:0034340)3.37554513
36type I interferon signaling pathway (GO:0060337)3.32056125
37cellular response to type I interferon (GO:0071357)3.32056125
38regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.30227903
39negative regulation of immunoglobulin mediated immune response (GO:0002890)3.28451912
40negative regulation of B cell mediated immunity (GO:0002713)3.28451912
41positive thymic T cell selection (GO:0045059)3.28305053
42regulation of tolerance induction (GO:0002643)3.27737714
43positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25491806
44positive regulation of defense response to virus by host (GO:0002230)3.24480436
45positive regulation of granulocyte differentiation (GO:0030854)3.24144747
46regulation of regulatory T cell differentiation (GO:0045589)3.21678265
47left/right pattern formation (GO:0060972)3.18843132
48detection of bacterium (GO:0016045)3.16689647
49positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14977291
50negative regulation of adaptive immune response (GO:0002820)3.14802096
51activated T cell proliferation (GO:0050798)3.14788206
52histone H3-K36 demethylation (GO:0070544)3.06854552
53negative regulation of leukocyte mediated immunity (GO:0002704)3.06246095
54interferon-gamma production (GO:0032609)3.05841344
55positive T cell selection (GO:0043368)3.05712548
56thymic T cell selection (GO:0045061)3.05415975
57regulation of B cell differentiation (GO:0045577)3.05322783
58CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.05121053
59negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.00289557
60detection of other organism (GO:0098543)2.97522783
61G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.95852449
62T cell selection (GO:0045058)2.93502150
63centriole assembly (GO:0098534)2.93300708
64regulation of interleukin-4 production (GO:0032673)2.88594672
65negative regulation of B cell proliferation (GO:0030889)2.87564471
66positive regulation of B cell differentiation (GO:0045579)2.87390672
67regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.85346531
68regulation of natural killer cell mediated immunity (GO:0002715)2.81076222
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81076222
70mast cell activation (GO:0045576)2.80318454
71cellular response to exogenous dsRNA (GO:0071360)2.79522948
72negative regulation of T cell mediated immunity (GO:0002710)2.79046211
73interferon-gamma-mediated signaling pathway (GO:0060333)2.78491185
74vitamin transmembrane transport (GO:0035461)2.77124010
75positive regulation of signal transduction by p53 class mediator (GO:1901798)2.75311845
76negative regulation of bone resorption (GO:0045779)2.74572448
77antigen receptor-mediated signaling pathway (GO:0050851)2.72499283
78positive regulation of T cell mediated cytotoxicity (GO:0001916)2.71443862
79immunoglobulin mediated immune response (GO:0016064)2.70838600
80regulation of T cell mediated cytotoxicity (GO:0001914)2.70641330
81primary alcohol catabolic process (GO:0034310)2.70527313
82cilium organization (GO:0044782)2.64801119
83negative regulation of B cell activation (GO:0050869)2.63278612
84positive regulation of antigen processing and presentation (GO:0002579)2.62450657
85regulation of antigen processing and presentation (GO:0002577)2.62282197
86ventricular system development (GO:0021591)2.61946320
87response to interferon-beta (GO:0035456)2.61326958
88regulation of interleukin-13 production (GO:0032656)2.59389868
89negative regulation of T cell differentiation in thymus (GO:0033085)2.58379155
90lymphocyte migration (GO:0072676)2.57109631
91negative regulation of viral genome replication (GO:0045071)2.56975465
92germinal center formation (GO:0002467)2.53179590
93cellular extravasation (GO:0045123)2.51393444
94regulation of leukocyte mediated cytotoxicity (GO:0001910)2.51256175
95B cell homeostasis (GO:0001782)2.51232531
96B cell mediated immunity (GO:0019724)2.51020966
97positive regulation of interleukin-2 production (GO:0032743)2.50067636
98positive regulation of interleukin-4 production (GO:0032753)2.49857115
99positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.49421862
100cilium assembly (GO:0042384)2.48972894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.99255278
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.27245294
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.44631990
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.29818246
5MYB_26560356_Chip-Seq_TH2_Human3.38939112
6RUNX_20019798_ChIP-Seq_JUKART_Human3.04262604
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91858965
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.66327811
9MYB_26560356_Chip-Seq_TH1_Human2.52580648
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44230753
11E2F7_22180533_ChIP-Seq_HELA_Human2.42078641
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40197575
13SCL_19346495_ChIP-Seq_HPC-7_Human2.36685151
14GATA3_27048872_Chip-Seq_THYMUS_Human2.34155865
15MAF_26560356_Chip-Seq_TH1_Human2.32344173
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.30736861
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.21016159
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16128068
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.16089757
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13887194
21* SPI1_23547873_ChIP-Seq_NB4_Human1.98099479
22* GATA3_26560356_Chip-Seq_TH2_Human1.97892947
23UTX_26944678_Chip-Seq_JUKART_Human1.94898453
24MYC_22102868_ChIP-Seq_BL_Human1.92926591
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.92877544
26VDR_24763502_ChIP-Seq_THP-1_Human1.85364201
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83366380
28CIITA_25753668_ChIP-Seq_RAJI_Human1.72689396
29DROSHA_22980978_ChIP-Seq_HELA_Human1.69838019
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69751789
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69639441
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64994687
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64522875
34VDR_21846776_ChIP-Seq_THP-1_Human1.63893885
35MAF_26560356_Chip-Seq_TH2_Human1.63479358
36SMRT_27268052_Chip-Seq_Bcells_Human1.53458353
37SPI1_23127762_ChIP-Seq_K562_Human1.52097643
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.49865336
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49440018
40GATA1_22025678_ChIP-Seq_K562_Human1.46685640
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43691769
42VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.40893956
43VDR_22108803_ChIP-Seq_LS180_Human1.40204986
44VDR_24787735_ChIP-Seq_THP-1_Human1.38869751
45STAT1_20625510_ChIP-Seq_HELA_Human1.34588178
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30361558
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.27220885
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.25286213
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23219781
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23127156
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22807106
52RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19784385
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19517945
54TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17729713
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17496711
56GATA1_19941826_ChIP-Seq_K562_Human1.16848106
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14655703
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14115974
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13148718
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12765693
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12081651
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10169612
63CEBPB_22108803_ChIP-Seq_LS180_Human1.06691470
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05176473
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.02539442
66P300_27268052_Chip-Seq_Bcells_Human1.01376829
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00013618
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97227235
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96223598
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95458712
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94168746
72TCF7_22412390_ChIP-Seq_EML_Mouse0.94045758
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92902758
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92844234
75FLI1_27457419_Chip-Seq_LIVER_Mouse0.92146988
76TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.91999384
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.91872490
78FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91872490
79AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90517398
80GATA2_19941826_ChIP-Seq_K562_Human0.89978759
81AR_20517297_ChIP-Seq_VCAP_Human0.89957363
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89922938
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88937622
84GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87672907
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85791212
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85457421
87BCL6_27268052_Chip-Seq_Bcells_Human0.84289631
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.82813476
89E2F4_17652178_ChIP-ChIP_JURKAT_Human0.81656040
90GATA3_26560356_Chip-Seq_TH1_Human0.81527397
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79680120
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79234359
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.77774748
94BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.76804951
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76450030
96ZNF274_21170338_ChIP-Seq_K562_Hela0.76149501
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75991450
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75709652
99SPI1_20517297_ChIP-Seq_HL60_Human0.74578099
100* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73936038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.99920070
2MP0005671_abnormal_response_to3.92993084
3MP0003763_abnormal_thymus_physiology3.81993456
4MP0001800_abnormal_humoral_immune3.21221819
5MP0005387_immune_system_phenotype2.99844603
6MP0001790_abnormal_immune_system2.99844603
7MP0000685_abnormal_immune_system2.80119128
8MP0003436_decreased_susceptibility_to2.74645644
9MP0008057_abnormal_DNA_replication2.58117939
10MP0002723_abnormal_immune_serum2.52392806
11MP0002452_abnormal_antigen_presenting2.50833659
12MP0002420_abnormal_adaptive_immunity2.49030591
13MP0002132_abnormal_respiratory_system2.48791502
14MP0001819_abnormal_immune_cell2.46634766
15MP0005000_abnormal_immune_tolerance2.45614733
16MP0005025_abnormal_response_to2.33812248
17MP0003724_increased_susceptibility_to2.31888521
18MP0002653_abnormal_ependyma_morphology2.27541007
19MP0002398_abnormal_bone_marrow2.23916233
20MP0009785_altered_susceptibility_to2.20903400
21MP0010155_abnormal_intestine_physiology2.19012035
22MP0002166_altered_tumor_susceptibility2.12568957
23MP0002419_abnormal_innate_immunity2.06294258
24MP0002277_abnormal_respiratory_mucosa2.06195641
25MP0000716_abnormal_immune_system1.99773928
26MP0000689_abnormal_spleen_morphology1.98526291
27MP0008875_abnormal_xenobiotic_pharmacok1.96871671
28MP0002396_abnormal_hematopoietic_system1.95098065
29MP0003656_abnormal_erythrocyte_physiolo1.93424537
30MP0009333_abnormal_splenocyte_physiolog1.90527227
31MP0002405_respiratory_system_inflammati1.89567196
32MP0000703_abnormal_thymus_morphology1.87331361
33MP0002722_abnormal_immune_system1.86064407
34MP0005623_abnormal_meninges_morphology1.86022725
35MP0002148_abnormal_hypersensitivity_rea1.81548427
36MP0003866_abnormal_defecation1.64675432
37MP0002006_tumorigenesis1.63796880
38MP0002429_abnormal_blood_cell1.63358688
39MP0004947_skin_inflammation1.62102423
40MP0003303_peritoneal_inflammation1.55183218
41MP0003878_abnormal_ear_physiology1.53411707
42MP0005377_hearing/vestibular/ear_phenot1.53411707
43MP0001845_abnormal_inflammatory_respons1.50819048
44MP0004043_abnormal_pH_regulation1.48332721
45MP0004147_increased_porphyrin_level1.48002612
46MP0000858_altered_metastatic_potential1.47973788
47MP0006082_CNS_inflammation1.47100403
48MP0002138_abnormal_hepatobiliary_system1.41996896
49MP0001873_stomach_inflammation1.37107578
50MP0005310_abnormal_salivary_gland1.32482758
51MP0010094_abnormal_chromosome_stability1.27599127
52MP0003045_fibrosis1.24054780
53MP0009278_abnormal_bone_marrow1.23704148
54MP0005075_abnormal_melanosome_morpholog1.19201866
55MP0002019_abnormal_tumor_incidence1.19150098
56MP0001545_abnormal_hematopoietic_system1.16195278
57MP0005397_hematopoietic_system_phenotyp1.16195278
58MP0005464_abnormal_platelet_physiology1.13249681
59MP0004381_abnormal_hair_follicle1.07058480
60MP0001533_abnormal_skeleton_physiology1.06995552
61MP0008469_abnormal_protein_level1.06052653
62MP0003786_premature_aging1.02033052
63MP0004808_abnormal_hematopoietic_stem1.01059532
64MP0001851_eye_inflammation0.94281387
65MP0000490_abnormal_crypts_of0.90316204
66MP0010307_abnormal_tumor_latency0.89630608
67MP0002933_joint_inflammation0.89595184
68MP0004264_abnormal_extraembryonic_tissu0.87996432
69MP0000465_gastrointestinal_hemorrhage0.87704022
70MP0002168_other_aberrant_phenotype0.87484254
71MP0003300_gastrointestinal_ulcer0.86640207
72MP0001663_abnormal_digestive_system0.84587562
73MP0002638_abnormal_pupillary_reflex0.83794054
74MP0009764_decreased_sensitivity_to0.83655115
75MP0002009_preneoplasia0.81810903
76MP0001765_abnormal_ion_homeostasis0.81179669
77MP0009763_increased_sensitivity_to0.80616683
78MP0003787_abnormal_imprinting0.79835976
79MP0008872_abnormal_physiological_respon0.78064532
80MP0008877_abnormal_DNA_methylation0.78007921
81MP0005083_abnormal_biliary_tract0.77142571
82MP0009765_abnormal_xenobiotic_induced0.76214246
83MP0003183_abnormal_peptide_metabolism0.75488865
84MP0005220_abnormal_exocrine_pancreas0.74836439
85MP0003943_abnormal_hepatobiliary_system0.69420530
86MP0005389_reproductive_system_phenotype0.69120690
87MP0002928_abnormal_bile_duct0.69059682
88MP0002163_abnormal_gland_morphology0.68920251
89MP0008995_early_reproductive_senescence0.67841598
90MP0002136_abnormal_kidney_physiology0.67066322
91MP0003950_abnormal_plasma_membrane0.65200533
92MP0008789_abnormal_olfactory_epithelium0.65000499
93MP0000470_abnormal_stomach_morphology0.64749039
94MP0000383_abnormal_hair_follicle0.63636721
95MP0001984_abnormal_olfaction0.63325196
96MP0002876_abnormal_thyroid_physiology0.62632013
97MP0002693_abnormal_pancreas_physiology0.61773655
98MP0004883_abnormal_blood_vessel0.61312462
99MP0005164_abnormal_response_to0.60478698
100MP0001853_heart_inflammation0.59722410

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.17333455
2Absent/shortened dynein arms (HP:0200106)8.17333455
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.97894505
4Abnormal respiratory epithelium morphology (HP:0012253)7.94235018
5Abnormal respiratory motile cilium morphology (HP:0005938)7.94235018
6Abnormal ciliary motility (HP:0012262)7.79649190
7Abnormal respiratory motile cilium physiology (HP:0012261)7.59911584
8Rhinitis (HP:0012384)6.58509610
9Bronchiectasis (HP:0002110)6.27138512
10Chronic bronchitis (HP:0004469)5.76224468
11Nasal polyposis (HP:0100582)5.31770944
12Recurrent sinusitis (HP:0011108)4.72867569
13Bronchitis (HP:0012387)4.68527379
14Chronic sinusitis (HP:0011109)4.28570748
15Abnormality of the nasal mucosa (HP:0000433)4.18033669
16Chronic otitis media (HP:0000389)4.17085161
17Recurrent bronchitis (HP:0002837)3.94485630
18Recurrent otitis media (HP:0000403)3.53439135
19Panhypogammaglobulinemia (HP:0003139)3.31390353
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.21087352
21IgG deficiency (HP:0004315)3.00286649
22T lymphocytopenia (HP:0005403)2.87784375
23Pancreatic fibrosis (HP:0100732)2.84961526
24Abnormality of T cell number (HP:0011839)2.82117212
25Pancreatic cysts (HP:0001737)2.75977476
26Elevated erythrocyte sedimentation rate (HP:0003565)2.74928872
27Hyperactive renin-angiotensin system (HP:0000841)2.69414139
28Infertility (HP:0000789)2.65735351
29True hermaphroditism (HP:0010459)2.62557302
30Chronic hepatic failure (HP:0100626)2.61289078
31IgM deficiency (HP:0002850)2.59031937
32Agammaglobulinemia (HP:0004432)2.55547830
33Recurrent viral infections (HP:0004429)2.55025773
34Abnormality of T cells (HP:0002843)2.54131190
35Encephalitis (HP:0002383)2.51276554
36Recurrent fungal infections (HP:0002841)2.49367744
37Molar tooth sign on MRI (HP:0002419)2.48342365
38Abnormality of midbrain morphology (HP:0002418)2.48342365
39Cystic liver disease (HP:0006706)2.45458045
40Recurrent cutaneous fungal infections (HP:0011370)2.40103481
41Chronic mucocutaneous candidiasis (HP:0002728)2.40103481
42Meningitis (HP:0001287)2.36665307
43Recurrent bacterial skin infections (HP:0005406)2.34597983
44Myositis (HP:0100614)2.26996754
45Asplenia (HP:0001746)2.24178142
46Aplasia/Hypoplasia of the spleen (HP:0010451)2.21278147
47Recurrent abscess formation (HP:0002722)2.19635674
48Eczematoid dermatitis (HP:0000976)2.19221831
49Abnormality of T cell physiology (HP:0011840)2.19156278
50Nephronophthisis (HP:0000090)2.15683843
51Abnormality of B cell number (HP:0010975)2.15502405
52Severe combined immunodeficiency (HP:0004430)2.12984529
53Male infertility (HP:0003251)2.11453958
54Papilledema (HP:0001085)2.08937679
55Eosinophilia (HP:0001880)2.06130512
56Abnormality of the pons (HP:0007361)2.05980213
57Hypoplasia of the pons (HP:0012110)2.03006870
58Decreased circulating renin level (HP:0003351)2.01281904
59Abnormality of eosinophils (HP:0001879)2.00842534
60Granulocytopenia (HP:0001913)2.00732327
61IgA deficiency (HP:0002720)1.91833563
62Autoimmune hemolytic anemia (HP:0001890)1.91024755
63Retrobulbar optic neuritis (HP:0100654)1.89366489
64Optic neuritis (HP:0100653)1.89366489
65Increased IgM level (HP:0003496)1.86820291
66Abnormality of the renal medulla (HP:0100957)1.86817234
67Colitis (HP:0002583)1.86707435
68B lymphocytopenia (HP:0010976)1.86706710
69Fatigue (HP:0012378)1.86355944
70Vasculitis (HP:0002633)1.85366386
71Pustule (HP:0200039)1.84233658
72Recurrent skin infections (HP:0001581)1.81746335
73Lymphopenia (HP:0001888)1.81722298
74Hyperkalemia (HP:0002153)1.80860995
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80683232
76Inflammation of the large intestine (HP:0002037)1.78905708
77Hypochromic microcytic anemia (HP:0004840)1.76794486
78Abnormality of cells of the lymphoid lineage (HP:0012140)1.75777051
79Cone-rod dystrophy (HP:0000548)1.75774937
80Occipital encephalocele (HP:0002085)1.73805807
81Leukocytosis (HP:0001974)1.73505721
82Postaxial foot polydactyly (HP:0001830)1.72689163
83Cerebellar dysplasia (HP:0007033)1.72469286
84Abolished electroretinogram (ERG) (HP:0000550)1.71001580
85Stomatitis (HP:0010280)1.70693106
86Combined immunodeficiency (HP:0005387)1.70589083
87Type II lissencephaly (HP:0007260)1.70387810
88Stomach cancer (HP:0012126)1.69814122
89Gastrointestinal stroma tumor (HP:0100723)1.69403030
90Mediastinal lymphadenopathy (HP:0100721)1.69061606
91Orchitis (HP:0100796)1.68198160
92Gastrointestinal inflammation (HP:0004386)1.67410125
93Congenital hepatic fibrosis (HP:0002612)1.67021565
94Increased IgE level (HP:0003212)1.66258517
95Chronic diarrhea (HP:0002028)1.62946319
96Absent frontal sinuses (HP:0002688)1.62345709
97Hypochromic anemia (HP:0001931)1.60154449
98Recurrent pneumonia (HP:0006532)1.59135982
99Abnormality of chloride homeostasis (HP:0011422)1.58863278
100Hypoplasia of the thymus (HP:0000778)1.58085845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.90840450
2MAPK153.59659459
3STK103.58510468
4MST43.31079664
5MARK33.22282192
6TXK2.98768207
7RIPK42.78859709
8TYK22.21453577
9ACVR1B2.18701448
10FRK2.10722103
11TEC2.03164233
12TAOK32.00048458
13BTK1.89299387
14KIT1.83301213
15GRK61.75246505
16MAP3K141.68809528
17CSK1.66816709
18ITK1.63925490
19JAK11.63856347
20IKBKE1.59108296
21SYK1.56471514
22PASK1.53675657
23BLK1.49389813
24MAP3K131.47126614
25PTK2B1.44880112
26TESK21.42862808
27TNK21.41991033
28PIM11.39191982
29IRAK41.36627212
30NLK1.35766038
31JAK31.29417247
32LCK1.22810134
33PRKCQ1.21825832
34ZAP701.21800493
35TBK11.15148914
36CSF1R1.14604382
37MAPKAPK31.12315340
38MAP3K71.12079380
39LYN1.11329267
40IKBKB1.09882957
41SIK21.09549375
42SMG11.07571776
43FES1.04648905
44HIPK21.03925737
45STK111.02350157
46MAP2K21.01424655
47SIK31.00093882
48HCK0.98621530
49PRKCH0.98359924
50TLK10.97176995
51PRPF4B0.95232740
52MAP3K100.94453611
53NUAK10.94041086
54MELK0.89516426
55CDK190.78235994
56CDK40.76481722
57BRSK20.76138630
58TRPM70.73513476
59MATK0.72718596
60EPHA20.71890029
61GRK10.67281195
62ERN10.65849525
63FGFR30.65253567
64IRAK10.65126515
65EPHB10.61839273
66MAPK110.61289610
67MAP2K30.59152300
68MAPK70.59126134
69MAP3K30.59023544
70NME10.58352668
71CAMKK10.58032801
72ATR0.56750471
73CDC70.56418111
74STK240.55935244
75EEF2K0.55334966
76RPS6KB20.53983659
77BMPR20.51961671
78MARK20.51827823
79JAK20.49448150
80CLK10.47444734
81INSRR0.46499442
82PRKCI0.45983784
83FLT30.45785332
84FGR0.44105186
85CDC42BPA0.43638206
86YES10.41649400
87PDK10.41284471
88CHUK0.40678576
89FYN0.37514691
90CDK120.36354298
91FGFR40.36218677
92EIF2AK30.36080234
93MST1R0.34974015
94TTK0.34640396
95PRKCD0.33784206
96NEK20.32726677
97LRRK20.32670150
98ABL10.32560166
99PIK3CG0.32212944
100MAP3K110.30123660

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.30235226
2Graft-versus-host disease_Homo sapiens_hsa053323.68935775
3Allograft rejection_Homo sapiens_hsa053303.31768137
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.19026524
5Autoimmune thyroid disease_Homo sapiens_hsa053203.10255545
6Asthma_Homo sapiens_hsa053102.56572659
7Type I diabetes mellitus_Homo sapiens_hsa049402.53208142
8Antigen processing and presentation_Homo sapiens_hsa046122.48015742
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35313921
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.21056639
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.08779198
12Leishmaniasis_Homo sapiens_hsa051402.08720547
13B cell receptor signaling pathway_Homo sapiens_hsa046622.02913240
14Hematopoietic cell lineage_Homo sapiens_hsa046401.93451242
15Herpes simplex infection_Homo sapiens_hsa051681.86528508
16T cell receptor signaling pathway_Homo sapiens_hsa046601.81762284
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80508138
18Measles_Homo sapiens_hsa051621.77388460
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58491619
20Viral myocarditis_Homo sapiens_hsa054161.58409849
21Staphylococcus aureus infection_Homo sapiens_hsa051501.55414146
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49031888
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48306113
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42175439
25Influenza A_Homo sapiens_hsa051641.41169448
26Caffeine metabolism_Homo sapiens_hsa002321.39927163
27Osteoclast differentiation_Homo sapiens_hsa043801.39598882
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.34453010
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29252070
30Homologous recombination_Homo sapiens_hsa034401.28167174
31Chemical carcinogenesis_Homo sapiens_hsa052041.21210392
32Toxoplasmosis_Homo sapiens_hsa051451.19336095
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15279223
34TNF signaling pathway_Homo sapiens_hsa046681.13252366
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10041351
36Hepatitis C_Homo sapiens_hsa051601.09323872
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07802160
38Linoleic acid metabolism_Homo sapiens_hsa005911.04260435
39Tuberculosis_Homo sapiens_hsa051521.03626407
40Mismatch repair_Homo sapiens_hsa034300.99375795
41Epstein-Barr virus infection_Homo sapiens_hsa051690.96806008
42Fanconi anemia pathway_Homo sapiens_hsa034600.92264517
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90676512
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89524074
45Chemokine signaling pathway_Homo sapiens_hsa040620.89316673
46Apoptosis_Homo sapiens_hsa042100.87480100
47DNA replication_Homo sapiens_hsa030300.87447493
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.86620692
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85919159
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85142585
51ABC transporters_Homo sapiens_hsa020100.82181041
52Histidine metabolism_Homo sapiens_hsa003400.80448132
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80270604
54Hepatitis B_Homo sapiens_hsa051610.79963746
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77719282
56Acute myeloid leukemia_Homo sapiens_hsa052210.77447723
57Malaria_Homo sapiens_hsa051440.76066202
58Nucleotide excision repair_Homo sapiens_hsa034200.72254171
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.69571810
60HTLV-I infection_Homo sapiens_hsa051660.67695538
61p53 signaling pathway_Homo sapiens_hsa041150.64928577
62Non-homologous end-joining_Homo sapiens_hsa034500.63185926
63African trypanosomiasis_Homo sapiens_hsa051430.60663143
64Base excision repair_Homo sapiens_hsa034100.58945995
65Viral carcinogenesis_Homo sapiens_hsa052030.58426685
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58101971
67Phenylalanine metabolism_Homo sapiens_hsa003600.53516990
68Arachidonic acid metabolism_Homo sapiens_hsa005900.52886561
69Non-small cell lung cancer_Homo sapiens_hsa052230.52291175
70Pancreatic cancer_Homo sapiens_hsa052120.52268512
71Rheumatoid arthritis_Homo sapiens_hsa053230.51366638
72Retinol metabolism_Homo sapiens_hsa008300.50394401
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49684503
74Platelet activation_Homo sapiens_hsa046110.45170657
75Glycerolipid metabolism_Homo sapiens_hsa005610.43611241
76Systemic lupus erythematosus_Homo sapiens_hsa053220.43211673
77Legionellosis_Homo sapiens_hsa051340.41741989
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40496484
79Choline metabolism in cancer_Homo sapiens_hsa052310.39622506
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39305171
81Phototransduction_Homo sapiens_hsa047440.39195420
82Notch signaling pathway_Homo sapiens_hsa043300.37770370
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37523898
84Tyrosine metabolism_Homo sapiens_hsa003500.35715490
85Prostate cancer_Homo sapiens_hsa052150.34742465
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.28524448
87Glutathione metabolism_Homo sapiens_hsa004800.27319281
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26647967
89mRNA surveillance pathway_Homo sapiens_hsa030150.26256320
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26158182
91Chronic myeloid leukemia_Homo sapiens_hsa052200.22755914
92Taste transduction_Homo sapiens_hsa047420.22387937
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22121593
94FoxO signaling pathway_Homo sapiens_hsa040680.21945831
95Olfactory transduction_Homo sapiens_hsa047400.20920467
96Ether lipid metabolism_Homo sapiens_hsa005650.20063714
97Colorectal cancer_Homo sapiens_hsa052100.19988992
98Small cell lung cancer_Homo sapiens_hsa052220.19905620
99Prolactin signaling pathway_Homo sapiens_hsa049170.19866566
100Insulin resistance_Homo sapiens_hsa049310.18334073

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