SLFN12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)4.69286872
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.66636329
3cellular extravasation (GO:0045123)4.13165555
4regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.01578337
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96770447
6positive regulation by organism of defense response of other organism involved in symbiotic interact3.96770447
7modulation by symbiont of host immune response (GO:0052553)3.96770447
8positive regulation by symbiont of host defense response (GO:0052509)3.96770447
9modulation by symbiont of host defense response (GO:0052031)3.96770447
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96770447
11response to interferon-alpha (GO:0035455)3.86133012
12positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.57287409
13macrophage activation involved in immune response (GO:0002281)3.55709820
14negative regulation of interleukin-12 production (GO:0032695)3.53371560
15response to peptidoglycan (GO:0032494)3.48663558
16neutrophil activation involved in immune response (GO:0002283)3.47345161
17cellular response to type I interferon (GO:0071357)3.37035976
18type I interferon signaling pathway (GO:0060337)3.37035976
19response to type I interferon (GO:0034340)3.33639912
20regulation of B cell receptor signaling pathway (GO:0050855)3.32636187
21membrane raft organization (GO:0031579)3.31809530
22wound healing, spreading of epidermal cells (GO:0035313)3.23978710
23microglial cell activation (GO:0001774)3.21995384
24positive regulation of interferon-alpha production (GO:0032727)3.19044873
25regulation of interferon-alpha production (GO:0032647)3.18869763
26detection of external biotic stimulus (GO:0098581)3.15668321
27response to host immune response (GO:0052572)3.13031812
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.13031812
29regulation of interferon-beta biosynthetic process (GO:0045357)3.08514370
30UDP-N-acetylglucosamine metabolic process (GO:0006047)3.05434898
31response to host (GO:0075136)3.04970731
32response to host defenses (GO:0052200)3.04970731
33response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.04970731
34retina vasculature morphogenesis in camera-type eye (GO:0061299)3.00701089
35positive regulation of toll-like receptor signaling pathway (GO:0034123)2.94952402
36cellular response to interferon-alpha (GO:0035457)2.92468864
37macrophage activation (GO:0042116)2.90345388
38cellular response to ethanol (GO:0071361)2.90157809
39positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.89620924
40regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.89341872
41regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89162110
42regulation of macrophage cytokine production (GO:0010935)2.88104175
43negative regulation of B cell proliferation (GO:0030889)2.87789938
44positive regulation of interferon-beta production (GO:0032728)2.85910885
45positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.82238552
46regulation of platelet aggregation (GO:0090330)2.82072627
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78081973
48cell adhesion mediated by integrin (GO:0033627)2.77685762
49detection of biotic stimulus (GO:0009595)2.76999693
50positive regulation of vasculogenesis (GO:2001214)2.72836072
51interleukin-6-mediated signaling pathway (GO:0070102)2.70242898
52positive regulation of macrophage cytokine production (GO:0060907)2.69149784
53substrate-dependent cell migration (GO:0006929)2.69118355
54wound healing, spreading of cells (GO:0044319)2.66232078
55phagocytosis, recognition (GO:0006910)2.65773136
56positive regulation of mast cell activation (GO:0033005)2.65765236
57B cell mediated immunity (GO:0019724)2.65259024
58positive regulation of gamma-delta T cell activation (GO:0046645)2.64793363
59detection of other organism (GO:0098543)2.64241219
60positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.61756970
61phagocytosis, engulfment (GO:0006911)2.60522054
62regulation of dendritic cell antigen processing and presentation (GO:0002604)2.58783286
63lipopolysaccharide-mediated signaling pathway (GO:0031663)2.58651025
64intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.58190690
65response to muramyl dipeptide (GO:0032495)2.57617179
66regulation of mast cell activation (GO:0033003)2.55720441
67myeloid cell activation involved in immune response (GO:0002275)2.55402010
68interferon-gamma-mediated signaling pathway (GO:0060333)2.50161972
69sprouting angiogenesis (GO:0002040)2.50122880
70positive regulation of interleukin-8 secretion (GO:2000484)2.47939062
71negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47533787
72negative regulation of cell killing (GO:0031342)2.47533787
73Rap protein signal transduction (GO:0032486)2.46994873
74histamine secretion (GO:0001821)2.46639376
75negative regulation of homotypic cell-cell adhesion (GO:0034111)2.45732857
76response to interferon-beta (GO:0035456)2.44996424
77immunoglobulin mediated immune response (GO:0016064)2.44833227
78positive regulation of interleukin-6 production (GO:0032755)2.43272427
79cellular response to exogenous dsRNA (GO:0071360)2.42016159
80platelet-derived growth factor receptor signaling pathway (GO:0048008)2.41229863
81T cell migration (GO:0072678)2.40186379
82regulation of T-helper 1 cell differentiation (GO:0045625)2.38974416
83negative regulation of nitric oxide biosynthetic process (GO:0045019)2.36835768
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35800780
85antigen processing and presentation of endogenous antigen (GO:0019883)2.35362001
86response to increased oxygen levels (GO:0036296)2.34149436
87response to hyperoxia (GO:0055093)2.34149436
88negative regulation of interleukin-17 production (GO:0032700)2.33615193
89positive regulation of interleukin-1 beta secretion (GO:0050718)2.33264720
90superoxide anion generation (GO:0042554)2.32945189
91prenylation (GO:0097354)2.32002885
92protein prenylation (GO:0018342)2.32002885
93regulation of vasculogenesis (GO:2001212)2.28582523
94regulation of platelet activation (GO:0010543)2.28241979
95defense response to virus (GO:0051607)2.28170790
96neutrophil mediated immunity (GO:0002446)2.26932611
97regulation of interferon-beta production (GO:0032648)2.26504648
98endothelium development (GO:0003158)2.26058271
99dendritic cell migration (GO:0036336)2.25858091
100negative regulation of viral genome replication (GO:0045071)2.24946329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.05570326
2SMAD_19615063_ChIP-ChIP_OVARY_Human4.30191976
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.79213977
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.41690309
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.87128334
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.70384522
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67052207
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59526086
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.50473209
10GATA2_21666600_ChIP-Seq_HMVEC_Human2.44737234
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43230941
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40823329
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.37342391
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36767523
15BRD4_25478319_ChIP-Seq_HGPS_Human2.29050454
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.28148213
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12849707
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10830120
19* CJUN_26792858_Chip-Seq_BT549_Human2.03805402
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02036661
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91763034
22ELK1_19687146_ChIP-ChIP_HELA_Human1.84263739
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.81779594
24GATA1_22025678_ChIP-Seq_K562_Human1.79735318
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79729194
26VDR_24787735_ChIP-Seq_THP-1_Human1.76387760
27NRF2_20460467_ChIP-Seq_MEFs_Mouse1.69836387
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.69836387
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67019327
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.66854398
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.66180684
32* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65387073
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.64555146
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62282325
35TP53_16413492_ChIP-PET_HCT116_Human1.61748957
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60480317
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.60065617
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55990486
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55990486
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55944952
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.51161460
42SPI1_23547873_ChIP-Seq_NB4_Human1.49001147
43TAF15_26573619_Chip-Seq_HEK293_Human1.46351767
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.42365287
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41737088
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38999004
47TP53_18474530_ChIP-ChIP_U2OS_Human1.37313596
48* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36202592
49EWS_26573619_Chip-Seq_HEK293_Human1.36178001
50* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34867834
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27656286
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26812656
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26502411
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26492280
55RUNX_20019798_ChIP-Seq_JUKART_Human1.24775057
56MYB_26560356_Chip-Seq_TH2_Human1.22513231
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21795488
58TP63_23658742_ChIP-Seq_EP156T_Human1.21549825
59P300_19829295_ChIP-Seq_ESCs_Human1.21351301
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.19799971
61CDX2_22108803_ChIP-Seq_LS180_Human1.18572286
62GATA3_26560356_Chip-Seq_TH2_Human1.17852906
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.17444100
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13633308
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13352050
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12537389
67GBX2_23144817_ChIP-Seq_PC3_Human1.11893632
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11058582
69PU_27001747_Chip-Seq_BMDM_Mouse1.10448140
70SPI1_23127762_ChIP-Seq_K562_Human1.10089386
71SALL4_22934838_ChIP-ChIP_CD34+_Human1.09956112
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09797361
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09293338
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09075607
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04789071
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.04423778
77* MYB_26560356_Chip-Seq_TH1_Human1.03537126
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02928224
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02429393
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00692054
81ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99808221
82ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97422527
83SCL_19346495_ChIP-Seq_HPC-7_Human0.96452912
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95817225
85BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93958882
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93917305
87* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92955145
88SMAD4_21799915_ChIP-Seq_A2780_Human0.92744711
89FOXM1_23109430_ChIP-Seq_U2OS_Human0.91460266
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91206240
91PIAS1_25552417_ChIP-Seq_VCAP_Human0.90938069
92ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90606474
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90484405
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90319927
95STAT3_23295773_ChIP-Seq_U87_Human0.90242705
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.89695703
97VDR_22108803_ChIP-Seq_LS180_Human0.88267118
98TFEB_21752829_ChIP-Seq_HELA_Human0.87692402
99E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87535944
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.86960950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.62704023
2MP0003724_increased_susceptibility_to3.28146599
3MP0003950_abnormal_plasma_membrane3.02314725
4MP0008438_abnormal_cutaneous_collagen2.92258613
5MP0001835_abnormal_antigen_presentation2.81935298
6MP0003828_pulmonary_edema2.78021126
7MP0000569_abnormal_digit_pigmentation2.58787138
8MP0003279_aneurysm2.51765233
9MP0004272_abnormal_basement_membrane2.51458038
10MP0006082_CNS_inflammation2.20702531
11MP0003191_abnormal_cellular_cholesterol2.14451006
12MP0003303_peritoneal_inflammation2.13722730
13MP0003566_abnormal_cell_adhesion2.12311850
14MP0010368_abnormal_lymphatic_system2.11019920
15MP0003300_gastrointestinal_ulcer2.03506538
16MP0003091_abnormal_cell_migration1.97794230
17MP0000685_abnormal_immune_system1.83998840
18MP0002419_abnormal_innate_immunity1.83912831
19MP0009785_altered_susceptibility_to1.83249489
20MP0002148_abnormal_hypersensitivity_rea1.80823635
21MP0010352_gastrointestinal_tract_polyps1.80518296
22MP0009764_decreased_sensitivity_to1.72387409
23MP0008260_abnormal_autophagy1.69342797
24MP0005464_abnormal_platelet_physiology1.66315390
25MP0005164_abnormal_response_to1.65875098
26MP0002452_abnormal_antigen_presenting1.65751847
27MP0003436_decreased_susceptibility_to1.58851600
28MP0003705_abnormal_hypodermis_morpholog1.58819535
29MP0001790_abnormal_immune_system1.58605565
30MP0005387_immune_system_phenotype1.58605565
31MP0001800_abnormal_humoral_immune1.55959515
32MP0000343_altered_response_to1.55711929
33MP0002723_abnormal_immune_serum1.53346638
34MP0004883_abnormal_blood_vessel1.53180406
35MP0005000_abnormal_immune_tolerance1.50284307
36MP0000015_abnormal_ear_pigmentation1.50264011
37MP0003045_fibrosis1.45669327
38MP0001879_abnormal_lymphatic_vessel1.43018104
39MP0003448_altered_tumor_morphology1.42630988
40MP0005275_abnormal_skin_tensile1.40636698
41MP0001533_abnormal_skeleton_physiology1.40059754
42MP0000767_abnormal_smooth_muscle1.38954882
43MP0005623_abnormal_meninges_morphology1.37678952
44MP0005025_abnormal_response_to1.37588199
45MP0002405_respiratory_system_inflammati1.35002777
46MP0005023_abnormal_wound_healing1.34339526
47MP0001819_abnormal_immune_cell1.31464685
48MP0002420_abnormal_adaptive_immunity1.30684788
49MP0005310_abnormal_salivary_gland1.29898510
50MP0001958_emphysema1.28555554
51MP0000858_altered_metastatic_potential1.25048934
52MP0008057_abnormal_DNA_replication1.23257360
53MP0005397_hematopoietic_system_phenotyp1.22591710
54MP0001545_abnormal_hematopoietic_system1.22591710
55MP0002168_other_aberrant_phenotype1.17772506
56MP0002254_reproductive_system_inflammat1.17495446
57MP0001853_heart_inflammation1.16823215
58MP0005174_abnormal_tail_pigmentation1.15284228
59MP0005595_abnormal_vascular_smooth1.14083929
60MP0005671_abnormal_response_to1.12988710
61MP0005171_absent_coat_pigmentation1.12685919
62MP0003941_abnormal_skin_development1.12265357
63MP0002332_abnormal_exercise_endurance1.12118323
64MP0001542_abnormal_bone_strength1.07308974
65MP0003763_abnormal_thymus_physiology1.06193681
66MP0001915_intracranial_hemorrhage1.05005056
67MP0001845_abnormal_inflammatory_respons1.04949727
68MP0000465_gastrointestinal_hemorrhage1.03707901
69MP0004947_skin_inflammation1.03394326
70MP0000249_abnormal_blood_vessel1.02840778
71MP0002998_abnormal_bone_remodeling1.01077353
72MP0002396_abnormal_hematopoietic_system0.99932714
73MP0004808_abnormal_hematopoietic_stem0.99239958
74MP0009384_cardiac_valve_regurgitation0.98517349
75MP0000716_abnormal_immune_system0.96376377
76MP0002877_abnormal_melanocyte_morpholog0.95473799
77MP0004484_altered_response_of0.95199738
78MP0001851_eye_inflammation0.94902538
79MP0002398_abnormal_bone_marrow0.93715357
80MP0002133_abnormal_respiratory_system0.93360942
81MP0005388_respiratory_system_phenotype0.93360942
82MP0008469_abnormal_protein_level0.90249259
83MP0008004_abnormal_stomach_pH0.90161475
84MP0005165_increased_susceptibility_to0.89909998
85MP0010155_abnormal_intestine_physiology0.89761058
86MP0002166_altered_tumor_susceptibility0.88171329
87MP0000371_diluted_coat_color0.86202579
88MP0002006_tumorigenesis0.85017684
89MP0009697_abnormal_copulation0.81657408
90MP0002138_abnormal_hepatobiliary_system0.81404190
91MP0005390_skeleton_phenotype0.80861853
92MP0000689_abnormal_spleen_morphology0.80377130
93MP0002429_abnormal_blood_cell0.77428242
94MP0003183_abnormal_peptide_metabolism0.77343666
95MP0005621_abnormal_cell_physiology0.77143109
96MP0002722_abnormal_immune_system0.76524448
97MP0005408_hypopigmentation0.76408782
98MP0002928_abnormal_bile_duct0.76013864
99MP0005167_abnormal_blood-brain_barrier0.75721599
100MP0002295_abnormal_pulmonary_circulatio0.75451089

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)3.83678243
2Recurrent bacterial skin infections (HP:0005406)3.55241515
3Hematochezia (HP:0002573)3.49240901
4Orchitis (HP:0100796)3.38998823
5Spondylolisthesis (HP:0003302)3.38025950
6Peritonitis (HP:0002586)3.37527277
7Aortic dissection (HP:0002647)3.34170536
8Myositis (HP:0100614)3.33481588
9Aortic aneurysm (HP:0004942)3.29111035
10Retrobulbar optic neuritis (HP:0100654)3.21976957
11Optic neuritis (HP:0100653)3.21976957
12Abnormality of T cell number (HP:0011839)3.19232488
13Recurrent abscess formation (HP:0002722)3.15476335
14Premature rupture of membranes (HP:0001788)3.06202340
15Vascular tortuosity (HP:0004948)3.00439926
16Arterial tortuosity (HP:0005116)2.98785854
17T lymphocytopenia (HP:0005403)2.89406781
18Abnormality of macrophages (HP:0004311)2.84704337
19Osteolytic defects of the hand bones (HP:0009699)2.81717907
20Osteolytic defects of the phalanges of the hand (HP:0009771)2.81717907
21Abnormal platelet volume (HP:0011876)2.79016113
22Conjunctival telangiectasia (HP:0000524)2.78425106
23Increased mean platelet volume (HP:0011877)2.78118299
24Myocardial infarction (HP:0001658)2.74671428
25Thoracolumbar scoliosis (HP:0002944)2.74169131
26Abnormality of the vasculature of the conjunctiva (HP:0008054)2.71044866
27Facial diplegia (HP:0001349)2.65912391
28Chronic mucocutaneous candidiasis (HP:0002728)2.56338112
29Recurrent cutaneous fungal infections (HP:0011370)2.56338112
30Eczematoid dermatitis (HP:0000976)2.55851394
31Subacute progressive viral hepatitis (HP:0006572)2.54150209
32Elevated erythrocyte sedimentation rate (HP:0003565)2.54002064
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.50705137
34Delayed closure of the anterior fontanelle (HP:0001476)2.50693958
35Abnormality of glycolipid metabolism (HP:0010969)2.47775158
36Abnormality of liposaccharide metabolism (HP:0010968)2.47775158
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.47775158
38Hemoptysis (HP:0002105)2.44968568
39Recurrent skin infections (HP:0001581)2.44132262
40Gastrointestinal infarctions (HP:0005244)2.43555191
41Absent frontal sinuses (HP:0002688)2.43509350
42Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.41259054
43Autoimmune thrombocytopenia (HP:0001973)2.38698329
44Dilatation of the ascending aorta (HP:0005111)2.36020653
45Amaurosis fugax (HP:0100576)2.32929207
46Recurrent fungal infections (HP:0002841)2.32073346
47Autoimmune hemolytic anemia (HP:0001890)2.27589202
48Choroideremia (HP:0001139)2.25725732
49Follicular hyperkeratosis (HP:0007502)2.22900592
50Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.20848223
51Pulmonary infiltrates (HP:0002113)2.20218558
52Vertebral arch anomaly (HP:0008438)2.19909839
53Eosinophilia (HP:0001880)2.17501103
54Basal ganglia calcification (HP:0002135)2.17157300
55Mucosal telangiectasiae (HP:0100579)2.13074318
56Arterial thrombosis (HP:0004420)2.12402544
57Aortic regurgitation (HP:0001659)2.11313988
58Cutaneous melanoma (HP:0012056)2.10819911
59Albinism (HP:0001022)2.10594062
60Soft skin (HP:0000977)2.10076077
61Thick nail (HP:0001805)2.09971397
62Prolonged bleeding time (HP:0003010)2.09685902
63Epistaxis (HP:0000421)2.09475194
64Vasculitis (HP:0002633)2.05986129
65Keratoconjunctivitis sicca (HP:0001097)2.05949650
66Protrusio acetabuli (HP:0003179)2.04860958
67Keratoconjunctivitis (HP:0001096)2.02981781
68Entropion (HP:0000621)2.01493259
69Tetraparesis (HP:0002273)2.00837947
70Aortic valve stenosis (HP:0001650)1.99228190
71Increased IgM level (HP:0003496)1.98175517
72Abnormal auditory evoked potentials (HP:0006958)1.97371610
73Portal hypertension (HP:0001409)1.96949614
74Recurrent viral infections (HP:0004429)1.96025072
75Poikiloderma (HP:0001029)1.95247824
76Abnormality of the peritoneum (HP:0002585)1.94128352
77Broad ribs (HP:0000885)1.93325770
78Hypoplasia of the iris (HP:0007676)1.91546852
79Chest pain (HP:0100749)1.90245206
80Thrombocytosis (HP:0001894)1.88619015
81IgA deficiency (HP:0002720)1.88158943
82Leukocytosis (HP:0001974)1.88001269
83Periodontitis (HP:0000704)1.87322908
84Abnormality of T cells (HP:0002843)1.86355413
85Fatigue (HP:0012378)1.85969059
86Prostate neoplasm (HP:0100787)1.84565219
87Abnormality of the frontal sinuses (HP:0002687)1.84313161
88Cerebral hemorrhage (HP:0001342)1.84167830
89Abnormality of the pericardium (HP:0001697)1.84051030
90Porencephaly (HP:0002132)1.82790143
91Recurrent bronchitis (HP:0002837)1.82175845
92Cervical subluxation (HP:0003308)1.81544967
93Persistence of primary teeth (HP:0006335)1.77924608
94Viral hepatitis (HP:0006562)1.76318743
95Ankle contracture (HP:0006466)1.75267319
96Keratitis (HP:0000491)1.75069318
97Atrophic scars (HP:0001075)1.75057116
98Premature loss of primary teeth (HP:0006323)1.74589265
99Deep philtrum (HP:0002002)1.74501811
100Spinal cord lesions (HP:0100561)1.74191838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.62993409
2BLK3.01258219
3TGFBR22.61064731
4TYK22.43820750
5TAF12.41139187
6TIE12.37644132
7MYLK2.22043520
8JAK32.11654335
9MST42.06232458
10BRSK22.05789631
11ACVR1B2.03083855
12ERBB41.94585441
13MAP3K141.91581343
14JAK11.91405427
15PIK3CG1.87012861
16TEC1.85527341
17EIF2AK31.79127501
18MAP3K31.77881430
19GRK71.75388614
20CSK1.71032204
21IRAK41.69689716
22NEK91.66997100
23FGR1.53853542
24NUAK11.53069061
25MAP3K121.50430292
26STK31.48830514
27MAP2K31.46942653
28BMPR21.44096231
29MELK1.38279417
30YES11.35894086
31KIT1.35484281
32PTK2B1.33888534
33IKBKE1.30366277
34WEE11.29878855
35STK101.25378476
36NEK11.22658474
37ZAP701.17398831
38IRAK11.14060446
39TGFBR11.13896212
40TRIM281.09047501
41PAK41.05856757
42RIPK41.03618265
43ADRBK21.02954820
44HCK1.02359554
45IKBKB1.00883306
46SIK31.00511025
47MARK30.99763675
48FER0.98763919
49NLK0.97526744
50TXK0.96157304
51MOS0.95021577
52PLK20.93831989
53BTK0.92761672
54PDGFRB0.92715542
55TBK10.91287632
56TRPM70.87468345
57LYN0.84056798
58DDR20.84054258
59MAPK70.83747269
60BMPR1B0.82555306
61EIF2AK20.79901503
62ADRBK10.79793873
63PLK30.78903087
64PAK20.78307304
65LATS10.77845390
66MKNK20.77704944
67PDGFRA0.76589760
68SYK0.73433030
69EGFR0.73085053
70JAK20.72973810
71TTN0.72778899
72CSF1R0.71619941
73GRK50.69231475
74FES0.68756850
75LCK0.66721009
76BCR0.66355314
77CDK60.62339252
78EPHB10.60957924
79MKNK10.59594491
80PTK20.57173372
81FLT30.57016262
82CLK10.56670795
83CAMKK20.56061787
84KSR10.55597947
85STK380.52917168
86ABL10.52506076
87EIF2AK10.51826337
88ERBB30.50653271
89TSSK60.48117112
90MET0.47411273
91MAP3K20.46910638
92IGF1R0.46909319
93STK38L0.45611796
94STK240.44364378
95INSR0.41277472
96NEK20.40561334
97ITK0.39984597
98PRKCE0.39770927
99GSK3A0.39392022
100BRD40.38576937

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.50777787
2Leishmaniasis_Homo sapiens_hsa051402.36155907
3Graft-versus-host disease_Homo sapiens_hsa053322.05306508
4Osteoclast differentiation_Homo sapiens_hsa043801.95692497
5Malaria_Homo sapiens_hsa051441.95178389
6Allograft rejection_Homo sapiens_hsa053301.94627581
7Staphylococcus aureus infection_Homo sapiens_hsa051501.93924400
8Measles_Homo sapiens_hsa051621.93533338
9Legionellosis_Homo sapiens_hsa051341.92568369
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88269943
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87317962
12p53 signaling pathway_Homo sapiens_hsa041151.83347957
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82821761
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.79524235
15Autoimmune thyroid disease_Homo sapiens_hsa053201.77252258
16Toxoplasmosis_Homo sapiens_hsa051451.76176054
17Influenza A_Homo sapiens_hsa051641.75122029
18Tuberculosis_Homo sapiens_hsa051521.74932240
19Viral myocarditis_Homo sapiens_hsa054161.70155867
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63013429
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62407998
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.61324033
23Asthma_Homo sapiens_hsa053101.61317400
24Hematopoietic cell lineage_Homo sapiens_hsa046401.54380700
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53478288
26TNF signaling pathway_Homo sapiens_hsa046681.47979467
27Platelet activation_Homo sapiens_hsa046111.47592337
28Herpes simplex infection_Homo sapiens_hsa051681.45426573
29ECM-receptor interaction_Homo sapiens_hsa045121.45377339
30Hepatitis B_Homo sapiens_hsa051611.40241155
31Focal adhesion_Homo sapiens_hsa045101.38744727
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38051191
33Rheumatoid arthritis_Homo sapiens_hsa053231.37461026
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36135769
35Small cell lung cancer_Homo sapiens_hsa052221.35284284
36Antigen processing and presentation_Homo sapiens_hsa046121.33614635
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.28741047
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.25496226
39Phagosome_Homo sapiens_hsa041451.24003652
40Shigellosis_Homo sapiens_hsa051311.23793162
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.22391775
42African trypanosomiasis_Homo sapiens_hsa051431.20361211
43Apoptosis_Homo sapiens_hsa042101.17634484
44Dorso-ventral axis formation_Homo sapiens_hsa043201.17100964
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16663474
46Chemokine signaling pathway_Homo sapiens_hsa040621.12525664
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11265290
48B cell receptor signaling pathway_Homo sapiens_hsa046621.10144035
49Pertussis_Homo sapiens_hsa051331.09861747
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06672402
51Proteoglycans in cancer_Homo sapiens_hsa052051.04548348
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03618919
53Amoebiasis_Homo sapiens_hsa051461.03577512
54Selenocompound metabolism_Homo sapiens_hsa004501.01788574
55Lysosome_Homo sapiens_hsa041421.01114752
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96276451
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90174510
58Salmonella infection_Homo sapiens_hsa051320.88481837
59Pancreatic cancer_Homo sapiens_hsa052120.88312537
60Type I diabetes mellitus_Homo sapiens_hsa049400.87940184
61Viral carcinogenesis_Homo sapiens_hsa052030.86126700
62Adherens junction_Homo sapiens_hsa045200.85095135
63Hepatitis C_Homo sapiens_hsa051600.84800535
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81583908
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80667116
66Systemic lupus erythematosus_Homo sapiens_hsa053220.80213618
67Chronic myeloid leukemia_Homo sapiens_hsa052200.79374107
68MicroRNAs in cancer_Homo sapiens_hsa052060.78552603
69TGF-beta signaling pathway_Homo sapiens_hsa043500.72729945
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66724587
71Basal transcription factors_Homo sapiens_hsa030220.63753522
72T cell receptor signaling pathway_Homo sapiens_hsa046600.63683134
73Prostate cancer_Homo sapiens_hsa052150.62709636
74HTLV-I infection_Homo sapiens_hsa051660.62356590
75Other glycan degradation_Homo sapiens_hsa005110.62005003
76Pathways in cancer_Homo sapiens_hsa052000.61572963
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61559763
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61146184
79Epstein-Barr virus infection_Homo sapiens_hsa051690.59569363
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58587110
81Primary immunodeficiency_Homo sapiens_hsa053400.57899427
82Renal cell carcinoma_Homo sapiens_hsa052110.56639979
83FoxO signaling pathway_Homo sapiens_hsa040680.53271993
84Bladder cancer_Homo sapiens_hsa052190.49964648
85Melanoma_Homo sapiens_hsa052180.48749361
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46834812
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45789431
88HIF-1 signaling pathway_Homo sapiens_hsa040660.44824500
89Endocytosis_Homo sapiens_hsa041440.44462503
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43232406
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.42646714
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.40045936
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39616786
94Fanconi anemia pathway_Homo sapiens_hsa034600.38884620
95Homologous recombination_Homo sapiens_hsa034400.38870095
96Sphingolipid metabolism_Homo sapiens_hsa006000.37758504
97Non-homologous end-joining_Homo sapiens_hsa034500.37203772
98N-Glycan biosynthesis_Homo sapiens_hsa005100.37151788
99Proteasome_Homo sapiens_hsa030500.36759806
100Complement and coagulation cascades_Homo sapiens_hsa046100.35768607

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