SLCO5A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion transporter superfamily. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)9.80089452
2regulation of dendritic cell antigen processing and presentation (GO:0002604)6.67388464
3response to prostaglandin E (GO:0034695)5.27281105
4positive regulation of cell size (GO:0045793)4.97945445
5sphingosine metabolic process (GO:0006670)4.89978693
6diol metabolic process (GO:0034311)4.59673887
7sphingoid metabolic process (GO:0046519)4.59411544
8myeloid dendritic cell differentiation (GO:0043011)4.49071276
9positive regulation of antigen processing and presentation (GO:0002579)4.37195340
10growth hormone receptor signaling pathway (GO:0060396)4.20451720
11negative regulation of necroptotic process (GO:0060546)4.17759002
12behavioral response to nicotine (GO:0035095)4.11729360
13regulation of RIG-I signaling pathway (GO:0039535)4.10940147
14T-helper cell differentiation (GO:0042093)4.10520229
15CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.10520229
16regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.06403905
17positive regulation of developmental pigmentation (GO:0048087)3.98168436
18response to prostaglandin (GO:0034694)3.97648443
19interferon-gamma secretion (GO:0072643)3.96661874
20pyrimidine nucleobase catabolic process (GO:0006208)3.92021777
21sarcoplasmic reticulum calcium ion transport (GO:0070296)3.90661840
22positive regulation of filopodium assembly (GO:0051491)3.80510169
23dendritic cell differentiation (GO:0097028)3.79755024
24neuron recognition (GO:0008038)3.78657724
25axonal fasciculation (GO:0007413)3.78309547
26cell migration in hindbrain (GO:0021535)3.77837993
27central nervous system projection neuron axonogenesis (GO:0021952)3.64827502
28ganglion development (GO:0061548)3.63695629
29DNA methylation involved in gamete generation (GO:0043046)3.62595593
30cellular response to growth hormone stimulus (GO:0071378)3.59797087
31regulation of antigen processing and presentation (GO:0002577)3.58285885
32myeloid dendritic cell activation (GO:0001773)3.57583821
33cellular response to prostaglandin stimulus (GO:0071379)3.57335073
34negative regulation of cytosolic calcium ion concentration (GO:0051481)3.56939121
35alpha-beta T cell differentiation involved in immune response (GO:0002293)3.55222557
36alpha-beta T cell activation involved in immune response (GO:0002287)3.55222557
37T cell differentiation involved in immune response (GO:0002292)3.55222557
38regulation of pigment cell differentiation (GO:0050932)3.51275743
39regulation of protein glycosylation (GO:0060049)3.47187510
40regulation of necroptotic process (GO:0060544)3.44522784
41actin-myosin filament sliding (GO:0033275)3.41063527
42muscle filament sliding (GO:0030049)3.41063527
43regulation of T-helper 1 cell differentiation (GO:0045625)3.40563670
44positive regulation of granulocyte chemotaxis (GO:0071624)3.36535340
45negative regulation of necrotic cell death (GO:0060547)3.34174263
46myofibril assembly (GO:0030239)3.33608685
47postsynaptic membrane organization (GO:0001941)3.25449813
48protein-chromophore linkage (GO:0018298)3.24407836
49regulation of skeletal muscle contraction (GO:0014819)3.23724839
50regulation of relaxation of muscle (GO:1901077)3.23481272
51regulation of meiosis I (GO:0060631)3.22232852
52necroptotic process (GO:0070266)3.20226077
53protein polyglutamylation (GO:0018095)3.10565329
54regulation of interleukin-12 biosynthetic process (GO:0045075)3.08420803
55regulation of MHC class I biosynthetic process (GO:0045343)3.06800022
56substrate-independent telencephalic tangential migration (GO:0021826)3.05195833
57substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.05195833
58skeletal muscle adaptation (GO:0043501)3.03180550
59negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.02489357
60neutrophil activation (GO:0042119)2.99311913
61nucleobase catabolic process (GO:0046113)2.93927799
62positive regulation of neutrophil chemotaxis (GO:0090023)2.93526209
63positive regulation of neutrophil migration (GO:1902624)2.93526209
64sulfate transmembrane transport (GO:1902358)2.93192960
65DNA deamination (GO:0045006)2.92986395
66regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.92486444
67response to inactivity (GO:0014854)2.90251090
68L-fucose catabolic process (GO:0042355)2.90188515
69fucose catabolic process (GO:0019317)2.90188515
70L-fucose metabolic process (GO:0042354)2.90188515
71piRNA metabolic process (GO:0034587)2.89588381
72heart field specification (GO:0003128)2.88851533
73secondary heart field specification (GO:0003139)2.88851533
74neural tube formation (GO:0001841)2.87926736
75negative thymic T cell selection (GO:0045060)2.86890298
76negative regulation of telomere maintenance (GO:0032205)2.85023087
77antigen processing and presentation of endogenous antigen (GO:0019883)2.84715092
78response to pheromone (GO:0019236)2.81271657
79regulation of telomere maintenance (GO:0032204)2.80492765
80regulation of sarcomere organization (GO:0060297)2.78920773
81positive regulation of natural killer cell differentiation (GO:0032825)2.78794955
82actin-mediated cell contraction (GO:0070252)2.78307774
83ionotropic glutamate receptor signaling pathway (GO:0035235)2.78221248
84positive regulation of interleukin-12 production (GO:0032735)2.78048084
85regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.77718185
86axon extension (GO:0048675)2.77484785
87response to nitric oxide (GO:0071731)2.74967952
88cerebral cortex radially oriented cell migration (GO:0021799)2.74277272
89olfactory bulb development (GO:0021772)2.71807348
90neuronal action potential propagation (GO:0019227)2.71424759
91snRNA transcription (GO:0009301)2.71330143
92membrane depolarization during action potential (GO:0086010)2.71246293
93positive regulation of glycoprotein biosynthetic process (GO:0010560)2.70638959
94indolalkylamine metabolic process (GO:0006586)2.69554014
95epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69297020
96response to muscle activity (GO:0014850)2.68674345
97presynaptic membrane assembly (GO:0097105)2.68655056
98retinal ganglion cell axon guidance (GO:0031290)2.68357824
99response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.67761959
100sarcomere organization (GO:0045214)2.66806098
101cardiac myofibril assembly (GO:0055003)2.65337711
102granulocyte activation (GO:0036230)2.65305700
103spinal cord motor neuron differentiation (GO:0021522)2.65015855
104neurotransmitter-gated ion channel clustering (GO:0072578)2.64310504
105adaptation of signaling pathway (GO:0023058)2.63241463
106CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.62463555
107dendrite morphogenesis (GO:0048813)2.61419727
108retinal cone cell development (GO:0046549)2.60519911
109myoblast migration (GO:0051451)2.60308031
110sympathetic nervous system development (GO:0048485)2.59672933
111neuron cell-cell adhesion (GO:0007158)2.59598848
112positive regulation of heat generation (GO:0031652)2.59272375
113auditory behavior (GO:0031223)2.58190517
114peristalsis (GO:0030432)2.57766326
115muscle atrophy (GO:0014889)2.57596025
116synaptic transmission, cholinergic (GO:0007271)2.57364910
117central nervous system neuron axonogenesis (GO:0021955)2.56892497
118natural killer cell mediated cytotoxicity (GO:0042267)2.56708266
119natural killer cell mediated immunity (GO:0002228)2.56708266
120negative T cell selection (GO:0043383)2.56570084
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.55958107
122synaptic transmission, glutamatergic (GO:0035249)2.55327014
123regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.55282947
124necrotic cell death (GO:0070265)2.55088452
125regulation of vesicle fusion (GO:0031338)2.55030822
126sulfate transport (GO:0008272)2.54845054
127striated muscle atrophy (GO:0014891)2.54666509
128membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.54653193
129gamma-aminobutyric acid transport (GO:0015812)2.54599260
130regulation of filopodium assembly (GO:0051489)2.54112266
131skeletal muscle contraction (GO:0003009)2.53798955
132organelle disassembly (GO:1903008)2.53657516
133somite development (GO:0061053)2.53193254
134behavioral response to ethanol (GO:0048149)2.52530243
135regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52281159
136mechanosensory behavior (GO:0007638)2.52118392
137positive regulation of meiosis (GO:0045836)2.52108375
138regulation of cellular extravasation (GO:0002691)2.51941586
139negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.51549333
140regulation of cell communication by electrical coupling (GO:0010649)2.51227786
141regulation of action potential (GO:0098900)2.51112942
142regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.51020720
143regulation of hexokinase activity (GO:1903299)2.50928489
144regulation of glucokinase activity (GO:0033131)2.50928489
145presynaptic membrane organization (GO:0097090)2.50766586
146phasic smooth muscle contraction (GO:0014821)2.50179379
147ribonucleoprotein complex disassembly (GO:0032988)2.50077826
148glutamate receptor signaling pathway (GO:0007215)2.50035088
149kynurenine metabolic process (GO:0070189)2.49970424
150pyrimidine dimer repair (GO:0006290)2.49949380
151regulation of T cell tolerance induction (GO:0002664)2.49789185
152facial nerve structural organization (GO:0021612)2.48369735
153regulation of cAMP-dependent protein kinase activity (GO:2000479)2.48139663
154regulation of transforming growth factor beta2 production (GO:0032909)2.47064415
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.46553682
156axon extension involved in axon guidance (GO:0048846)2.46553682
157tryptophan catabolic process (GO:0006569)2.46317275
158indole-containing compound catabolic process (GO:0042436)2.46317275
159indolalkylamine catabolic process (GO:0046218)2.46317275
160dendritic cell chemotaxis (GO:0002407)2.46023341
161positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.45600772
162neuronal action potential (GO:0019228)2.45394651
163opioid receptor signaling pathway (GO:0038003)2.45026820
164programmed necrotic cell death (GO:0097300)2.44351786
165negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.43936876
166negative regulation of translation, ncRNA-mediated (GO:0040033)2.43936876
167regulation of translation, ncRNA-mediated (GO:0045974)2.43936876
168negative regulation of transcription regulatory region DNA binding (GO:2000678)2.43466217
169response to muramyl dipeptide (GO:0032495)2.43127397
170regulation of protein polyubiquitination (GO:1902914)2.43015526
171plasma membrane repair (GO:0001778)2.42845493
172intraciliary transport (GO:0042073)2.42218444
173regulation of protein oligomerization (GO:0032459)2.42042268
174negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.40938384
175regulation of energy homeostasis (GO:2000505)2.40878256
176kidney morphogenesis (GO:0060993)2.39970941
177regulation of fever generation (GO:0031620)2.39549649
178positive regulation of protein oligomerization (GO:0032461)2.39542263
179neuromuscular synaptic transmission (GO:0007274)2.39534103
180interkinetic nuclear migration (GO:0022027)2.39033297
181histone H3-K36 demethylation (GO:0070544)2.36540627
182limb bud formation (GO:0060174)2.36531510
183regulation of interleukin-1 beta secretion (GO:0050706)2.36451771
184regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35639041
185positive regulation of protein homooligomerization (GO:0032464)2.33215605
186dendritic spine morphogenesis (GO:0060997)2.31674355
187glial cell proliferation (GO:0014009)2.31065360
188CD4-positive, alpha-beta T cell activation (GO:0035710)2.31022360
189neuron projection extension (GO:1990138)2.29221820
190dendritic cell migration (GO:0036336)2.26961298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.53780722
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.32704450
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.13624330
4* IGF1R_20145208_ChIP-Seq_DFB_Human2.89210991
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.84916086
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37734401
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.33373856
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30466037
9GBX2_23144817_ChIP-Seq_PC3_Human2.25869909
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22027621
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13224626
12PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.11820073
13TAF15_26573619_Chip-Seq_HEK293_Human2.06507801
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05652737
15* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98995208
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98694769
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98694769
18* RNF2_27304074_Chip-Seq_ESCs_Mouse1.94347989
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92383793
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.90510814
21TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90510814
22FUS_26573619_Chip-Seq_HEK293_Human1.87502329
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80935528
24* FLI1_27457419_Chip-Seq_LIVER_Mouse1.78208291
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76934795
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76251480
27* EZH2_27294783_Chip-Seq_ESCs_Mouse1.75387505
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75339181
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75221607
30AHR_22903824_ChIP-Seq_MCF-7_Human1.74998756
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73668166
32DROSHA_22980978_ChIP-Seq_HELA_Human1.70862930
33* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70089789
34* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64277564
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64131492
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.61787658
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59164870
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.57596663
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.57461128
40* STAT3_23295773_ChIP-Seq_U87_Human1.55799226
41* TCF4_23295773_ChIP-Seq_U87_Human1.54029878
42P53_22127205_ChIP-Seq_FIBROBLAST_Human1.52865009
43* RING1B_27294783_Chip-Seq_NPCs_Mouse1.52837979
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47947847
45* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47918502
46* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47240737
47* CBP_20019798_ChIP-Seq_JUKART_Human1.47240737
48* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46446985
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41361122
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40726993
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40411819
52* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38185914
53AR_21572438_ChIP-Seq_LNCaP_Human1.37333486
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37026479
55* P300_19829295_ChIP-Seq_ESCs_Human1.36890337
56EWS_26573619_Chip-Seq_HEK293_Human1.36632292
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35882694
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35557329
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34798243
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34680180
61BCAT_22108803_ChIP-Seq_LS180_Human1.32066576
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31653647
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.29942892
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29613639
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29251278
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29102663
67SOX2_19829295_ChIP-Seq_ESCs_Human1.27807187
68NANOG_19829295_ChIP-Seq_ESCs_Human1.27807187
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27622361
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27468331
71* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26505247
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26405381
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26209777
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.25529582
75* NFE2_27457419_Chip-Seq_LIVER_Mouse1.24991216
76* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24532625
77* EZH2_27294783_Chip-Seq_NPCs_Mouse1.21619634
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21417649
79* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21083188
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21072805
81* VDR_24787735_ChIP-Seq_THP-1_Human1.20755751
82KDM2B_26808549_Chip-Seq_K562_Human1.20715348
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20493600
84* RING1B_27294783_Chip-Seq_ESCs_Mouse1.19424058
85REST_21632747_ChIP-Seq_MESCs_Mouse1.18809341
86* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18663338
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18602017
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.18228619
89* REST_18959480_ChIP-ChIP_MESCs_Mouse1.17894647
90* ER_23166858_ChIP-Seq_MCF-7_Human1.17833508
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17500511
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17113968
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16889805
94* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16640072
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16101442
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.15752118
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.14850340
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14013237
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13723029
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13113223
101* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13009103
102AR_25329375_ChIP-Seq_VCAP_Human1.12918798
103SMAD4_21799915_ChIP-Seq_A2780_Human1.12371375
104TCF4_22108803_ChIP-Seq_LS180_Human1.11695204
105STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11381076
106* RUNX2_22187159_ChIP-Seq_PCA_Human1.11328582
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.11258362
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11199913
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10249972
110RNF2_27304074_Chip-Seq_NSC_Mouse1.09194242
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.09156471
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06727495
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.06660495
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.05761179
115* P53_22387025_ChIP-Seq_ESCs_Mouse1.05332682
116* E2F1_18555785_Chip-Seq_ESCs_Mouse1.05270862
117TP53_18474530_ChIP-ChIP_U2OS_Human1.04898593
118SMAD4_21741376_ChIP-Seq_HESCs_Human1.04683790
119VDR_22108803_ChIP-Seq_LS180_Human1.04142887
120TP53_22573176_ChIP-Seq_HFKS_Human1.04094208
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03996206
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03491121
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03363990
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03120912
125* AR_19668381_ChIP-Seq_PC3_Human1.02778028
126* CRX_20693478_ChIP-Seq_RETINA_Mouse1.02333200
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02002199
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01803629
129EP300_21415370_ChIP-Seq_HL-1_Mouse1.01696137
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01374156
131KDM2B_26808549_Chip-Seq_REH_Human1.00699261
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.00320931
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99897221
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99488709
135ISL1_27105846_Chip-Seq_CPCs_Mouse0.99050126
136* CMYC_18555785_Chip-Seq_ESCs_Mouse0.98965821
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98352261
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98275577
139* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97915550
140TP53_20018659_ChIP-ChIP_R1E_Mouse0.97654001
141ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97059782
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96803602
143TP63_19390658_ChIP-ChIP_HaCaT_Human0.96691381
144SMAD3_21741376_ChIP-Seq_ESCs_Human0.96488184
145* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95705986
146STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94386787
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93342057
148TBL1_22424771_ChIP-Seq_293T_Human0.93207934
149* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93135563
150* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92987883
151DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92983994
152ZNF274_21170338_ChIP-Seq_K562_Hela0.92483065
153NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91328323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat8.69110410
2MP0002138_abnormal_hepatobiliary_system5.15225189
3MP0004510_myositis4.57355185
4MP0001348_abnormal_lacrimal_gland4.52062385
5MP0000569_abnormal_digit_pigmentation4.38539077
6MP0001346_abnormal_lacrimal_gland4.07636818
7MP0003136_yellow_coat_color3.28424752
8MP0002009_preneoplasia2.96634869
9MP0000685_abnormal_immune_system2.70808572
10MP0002277_abnormal_respiratory_mucosa2.70094749
11MP0005171_absent_coat_pigmentation2.60792477
12MP0000778_abnormal_nervous_system2.60614999
13MP0003045_fibrosis2.58921393
14MP0002653_abnormal_ependyma_morphology2.58237303
15MP0002877_abnormal_melanocyte_morpholog2.35274089
16MP0005645_abnormal_hypothalamus_physiol2.28729124
17MP0002876_abnormal_thyroid_physiology2.20680266
18MP0005310_abnormal_salivary_gland2.19957418
19MP0003880_abnormal_central_pattern2.10657847
20MP0002163_abnormal_gland_morphology2.04420055
21MP0006072_abnormal_retinal_apoptosis1.95804588
22MP0005423_abnormal_somatic_nervous1.89830628
23MP0001835_abnormal_antigen_presentation1.80645117
24MP0004142_abnormal_muscle_tone1.78107032
25MP0001873_stomach_inflammation1.75171819
26MP0002822_catalepsy1.69019727
27MP0002166_altered_tumor_susceptibility1.65393467
28MP0002735_abnormal_chemical_nociception1.59303212
29MP0009745_abnormal_behavioral_response1.57991250
30MP0001984_abnormal_olfaction1.57567480
31MP0006276_abnormal_autonomic_nervous1.57268811
32MP0004043_abnormal_pH_regulation1.55631888
33MP0002272_abnormal_nervous_system1.53204515
34MP0005253_abnormal_eye_physiology1.51797974
35MP0002332_abnormal_exercise_endurance1.51568806
36MP0004859_abnormal_synaptic_plasticity1.42053627
37MP0003195_calcinosis1.41821540
38MP0002638_abnormal_pupillary_reflex1.41311518
39MP0003787_abnormal_imprinting1.41049447
40MP0000537_abnormal_urethra_morphology1.38902741
41MP0002184_abnormal_innervation1.35698261
42MP0005551_abnormal_eye_electrophysiolog1.33904068
43MP0001529_abnormal_vocalization1.29725310
44MP0003890_abnormal_embryonic-extraembry1.27507972
45MP0001968_abnormal_touch/_nociception1.26239399
46MP0004215_abnormal_myocardial_fiber1.25982730
47MP0002269_muscular_atrophy1.24976143
48MP0004270_analgesia1.23953116
49MP0004924_abnormal_behavior1.21402170
50MP0005386_behavior/neurological_phenoty1.21402170
51MP0002837_dystrophic_cardiac_calcinosis1.19512738
52MP0001501_abnormal_sleep_pattern1.18880989
53MP0005387_immune_system_phenotype1.17620496
54MP0001790_abnormal_immune_system1.17620496
55MP0002572_abnormal_emotion/affect_behav1.17069167
56MP0002006_tumorigenesis1.16018968
57MP0005670_abnormal_white_adipose1.15794547
58MP0002064_seizures1.15301811
59MP0002102_abnormal_ear_morphology1.13086629
60MP0004036_abnormal_muscle_relaxation1.11118898
61MP0000733_abnormal_muscle_development1.10029175
62MP0005646_abnormal_pituitary_gland1.08591103
63MP0008057_abnormal_DNA_replication1.08272888
64MP0002067_abnormal_sensory_capabilities1.07684128
65MP0004130_abnormal_muscle_cell1.06584793
66MP0000631_abnormal_neuroendocrine_gland1.06207273
67MP0002736_abnormal_nociception_after1.03843879
68MP0000538_abnormal_urinary_bladder1.03456988
69MP0001970_abnormal_pain_threshold1.03191325
70MP0000751_myopathy1.02779271
71MP0002168_other_aberrant_phenotype1.02428267
72MP0002234_abnormal_pharynx_morphology1.01073236
73MP0008872_abnormal_physiological_respon0.99927849
74MP0005266_abnormal_metabolism0.99512227
75MP0000516_abnormal_urinary_system0.98824243
76MP0005367_renal/urinary_system_phenotyp0.98824243
77MP0000372_irregular_coat_pigmentation0.98031828
78MP0008789_abnormal_olfactory_epithelium0.96075797
79MP0003091_abnormal_cell_migration0.95691290
80MP0004858_abnormal_nervous_system0.94684450
81MP0005330_cardiomyopathy0.93477149
82MP0000613_abnormal_salivary_gland0.93449265
83MP0002751_abnormal_autonomic_nervous0.91246429
84MP0010386_abnormal_urinary_bladder0.88630565
85MP0005076_abnormal_cell_differentiation0.87969791
86MP0008877_abnormal_DNA_methylation0.87572975
87MP0005167_abnormal_blood-brain_barrier0.86877414
88MP0002938_white_spotting0.85649350
89MP0004885_abnormal_endolymph0.85172149
90MP0004381_abnormal_hair_follicle0.84851283
91MP0002106_abnormal_muscle_physiology0.84482824
92MP0003121_genomic_imprinting0.83813465
93MP0000427_abnormal_hair_cycle0.83110311
94MP0003183_abnormal_peptide_metabolism0.83084515
95MP0001986_abnormal_taste_sensitivity0.82374571
96MP0004085_abnormal_heartbeat0.82335947
97MP0004084_abnormal_cardiac_muscle0.77055557
98MP0004233_abnormal_muscle_weight0.76165484
99MP0005187_abnormal_penis_morphology0.75800796
100MP0003879_abnormal_hair_cell0.75458885
101MP0002063_abnormal_learning/memory/cond0.75196007
102MP0005195_abnormal_posterior_eye0.74749349
103MP0001188_hyperpigmentation0.74395006
104MP0005671_abnormal_response_to0.73991847
105MP0003385_abnormal_body_wall0.73589398
106MP0002734_abnormal_mechanical_nocicepti0.73057808
107MP0004147_increased_porphyrin_level0.73048708
108MP0002229_neurodegeneration0.72464197
109MP0001440_abnormal_grooming_behavior0.71976771
110MP0004145_abnormal_muscle_electrophysio0.71939239
111MP0004484_altered_response_of0.70960014
112MP0003635_abnormal_synaptic_transmissio0.70284814
113MP0001879_abnormal_lymphatic_vessel0.69023790
114MP0004811_abnormal_neuron_physiology0.67205028
115MP0002148_abnormal_hypersensitivity_rea0.66139192
116MP0003646_muscle_fatigue0.65114954
117MP0001485_abnormal_pinna_reflex0.64792855
118MP0005379_endocrine/exocrine_gland_phen0.64432019
119MP0005620_abnormal_muscle_contractility0.62749414
120MP0001299_abnormal_eye_distance/0.61133438
121MP0002882_abnormal_neuron_morphology0.60080115
122MP0003861_abnormal_nervous_system0.60040727
123MP0005499_abnormal_olfactory_system0.59647410
124MP0005394_taste/olfaction_phenotype0.59647410
125MP0003315_abnormal_perineum_morphology0.59277293
126MP0003137_abnormal_impulse_conducting0.59172000
127MP0001800_abnormal_humoral_immune0.58818322
128MP0005369_muscle_phenotype0.58196073
129MP0001270_distended_abdomen0.57526781
130MP0002233_abnormal_nose_morphology0.57173062
131MP0000759_abnormal_skeletal_muscle0.56982325
132MP0008775_abnormal_heart_ventricle0.54837330
133MP0004087_abnormal_muscle_fiber0.54612570
134MP0002733_abnormal_thermal_nociception0.54520944
135MP0006292_abnormal_olfactory_placode0.53748722
136MP0009046_muscle_twitch0.53370420
137MP0000579_abnormal_nail_morphology0.48951796
138MP0000026_abnormal_inner_ear0.48821343
139MP0003755_abnormal_palate_morphology0.48746624
140MP0003119_abnormal_digestive_system0.48598174
141MP0002152_abnormal_brain_morphology0.48426815
142MP0000470_abnormal_stomach_morphology0.48230351
143MP0000955_abnormal_spinal_cord0.47661629
144MP0000049_abnormal_middle_ear0.47055014
145MP0002116_abnormal_craniofacial_bone0.46762343
146MP0000749_muscle_degeneration0.46157493
147MP0004134_abnormal_chest_morphology0.46083922
148MP0003937_abnormal_limbs/digits/tail_de0.45639887
149MP0001486_abnormal_startle_reflex0.44826241
150MP0002972_abnormal_cardiac_muscle0.44358189
151MP0004133_heterotaxia0.43135025
152MP0002752_abnormal_somatic_nervous0.42475543
153MP0005248_abnormal_Harderian_gland0.41958116
154MP0002557_abnormal_social/conspecific_i0.41257995
155MP0002452_abnormal_antigen_presenting0.40937492
156MP0000767_abnormal_smooth_muscle0.40754036

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.24835260
2Cortical dysplasia (HP:0002539)4.06444347
3Recurrent cutaneous fungal infections (HP:0011370)3.74210145
4Chronic mucocutaneous candidiasis (HP:0002728)3.74210145
5Muscle fiber inclusion bodies (HP:0100299)3.65147378
6Pancreatic cysts (HP:0001737)3.54058903
7Hyperventilation (HP:0002883)3.42931383
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.39143499
9Focal seizures (HP:0007359)3.36807291
10Type II lissencephaly (HP:0007260)3.20676317
11Nemaline bodies (HP:0003798)3.17672179
12Nephronophthisis (HP:0000090)3.11663493
13Increased IgE level (HP:0003212)3.10321907
14Keratoconjunctivitis (HP:0001096)3.07561954
15Exotropia (HP:0000577)3.05392525
16Dialeptic seizures (HP:0011146)2.99994357
17Abnormality of the renal cortex (HP:0011035)2.97508835
18Recurrent fungal infections (HP:0002841)2.96905714
19Abnormality of the gastric mucosa (HP:0004295)2.91378934
20Hydroxyprolinuria (HP:0003080)2.90186836
21Abnormality of proline metabolism (HP:0010907)2.90186836
22Exercise-induced muscle cramps (HP:0003710)2.86767888
23Proximal amyotrophy (HP:0007126)2.82863137
24Wrist flexion contracture (HP:0001239)2.78809106
25Molar tooth sign on MRI (HP:0002419)2.76048808
26Abnormality of midbrain morphology (HP:0002418)2.76048808
27Amelogenesis imperfecta (HP:0000705)2.73957337
28Abnormality of the renal medulla (HP:0100957)2.73258314
29Lip pit (HP:0100267)2.68783671
30Colon cancer (HP:0003003)2.64931831
31Papillary thyroid carcinoma (HP:0002895)2.62141906
32Persistence of primary teeth (HP:0006335)2.60799762
33Myopathic facies (HP:0002058)2.59928856
34Cerebellar dysplasia (HP:0007033)2.58544628
35Inability to walk (HP:0002540)2.57229605
36Pancreatic fibrosis (HP:0100732)2.55437837
37Hyporeflexia of lower limbs (HP:0002600)2.53510619
38Right ventricular cardiomyopathy (HP:0011663)2.53451722
39Muscle hypertrophy of the lower extremities (HP:0008968)2.52512460
40Chronic hepatic failure (HP:0100626)2.50036539
41Fatigue (HP:0012378)2.47391157
42Pachygyria (HP:0001302)2.44773598
43True hermaphroditism (HP:0010459)2.44338453
44Abnormality of the fingertips (HP:0001211)2.43928366
45Aplasia cutis congenita (HP:0001057)2.41633685
46Type 1 muscle fiber predominance (HP:0003803)2.40427774
47Exercise-induced myalgia (HP:0003738)2.38084801
48Calf muscle hypertrophy (HP:0008981)2.37758521
49Pendular nystagmus (HP:0012043)2.36716507
50Medial flaring of the eyebrow (HP:0010747)2.35812757
51Fatigable weakness (HP:0003473)2.35803077
52Abnormality of the neuromuscular junction (HP:0003398)2.35803077
53Shoulder girdle muscle weakness (HP:0003547)2.34435203
54Congenital stationary night blindness (HP:0007642)2.32901169
55Rimmed vacuoles (HP:0003805)2.30655612
56Lower limb amyotrophy (HP:0007210)2.29371581
57Retrobulbar optic neuritis (HP:0100654)2.28868027
58Optic neuritis (HP:0100653)2.28868027
59Gait imbalance (HP:0002141)2.27007015
60Myoglobinuria (HP:0002913)2.26414003
61Absent frontal sinuses (HP:0002688)2.26109678
62Urinary urgency (HP:0000012)2.25123261
63Renal cortical cysts (HP:0000803)2.24859506
64Febrile seizures (HP:0002373)2.23477832
65Gaze-evoked nystagmus (HP:0000640)2.20204135
66Difficulty running (HP:0009046)2.18890439
67Frequent falls (HP:0002359)2.17375239
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.17168501
69Progressive inability to walk (HP:0002505)2.14940292
70Intestinal atresia (HP:0011100)2.14756254
71Cystic liver disease (HP:0006706)2.14433406
72Abnormality of the intervertebral disk (HP:0005108)2.11535787
73Scapular winging (HP:0003691)2.11113680
74Abnormality of calcium-phosphate metabolism (HP:0100530)2.11022218
75Progressive cerebellar ataxia (HP:0002073)2.09542438
76Retinal dysplasia (HP:0007973)2.09234609
77Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06554758
78Hypoplasia of the brainstem (HP:0002365)2.06554758
79Stomach cancer (HP:0012126)2.06433608
80Decreased circulating renin level (HP:0003351)2.06335745
81Hyperkalemia (HP:0002153)2.05319750
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03316031
83Parakeratosis (HP:0001036)2.01519445
84Hypoplastic iliac wings (HP:0002866)2.00996657
85Absent speech (HP:0001344)1.99608811
86Failure to thrive in infancy (HP:0001531)1.99435168
87Impaired vibration sensation in the lower limbs (HP:0002166)1.98704339
88Sudden death (HP:0001699)1.98421619
89Distal lower limb amyotrophy (HP:0008944)1.98329902
90Tetraparesis (HP:0002273)1.98106884
91Congenital primary aphakia (HP:0007707)1.98039339
92Nephrogenic diabetes insipidus (HP:0009806)1.97541575
93Hepatic necrosis (HP:0002605)1.97065248
94Pelvic girdle muscle weakness (HP:0003749)1.95987912
95Abnormality of the shoulder girdle musculature (HP:0001435)1.94483210
96Anencephaly (HP:0002323)1.94381116
97Supranuclear gaze palsy (HP:0000605)1.93087580
98Genetic anticipation (HP:0003743)1.92758920
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.92385891
100Hepatocellular necrosis (HP:0001404)1.92204791
101Protruding tongue (HP:0010808)1.92001057
102Ventricular tachycardia (HP:0004756)1.90205126
103Abnormality of the corticospinal tract (HP:0002492)1.90067050
104Agammaglobulinemia (HP:0004432)1.87065673
105Abnormal drinking behavior (HP:0030082)1.86791206
106Polydipsia (HP:0001959)1.86791206
107Hypothermia (HP:0002045)1.86284227
108Hypercortisolism (HP:0001578)1.85506526
109Prostate neoplasm (HP:0100787)1.84525652
110Tinnitus (HP:0000360)1.84519313
111Urinary bladder sphincter dysfunction (HP:0002839)1.83261014
112Prolonged QT interval (HP:0001657)1.83013054
113Genital tract atresia (HP:0001827)1.81371785
114Poor eye contact (HP:0000817)1.80958997
115Hemiparesis (HP:0001269)1.79776835
116Vaginal atresia (HP:0000148)1.79345843
117Left ventricular hypertrophy (HP:0001712)1.79118546
118Large for gestational age (HP:0001520)1.78600232
119Abnormal finger flexion creases (HP:0006143)1.78307521
120EMG: neuropathic changes (HP:0003445)1.77272634
121Difficulty walking (HP:0002355)1.77076648
122High anterior hairline (HP:0009890)1.76255408
123Drooling (HP:0002307)1.74072145
124Excessive salivation (HP:0003781)1.74072145
125Hypsarrhythmia (HP:0002521)1.72906274
126Distal arthrogryposis (HP:0005684)1.72643316
127Hematochezia (HP:0002573)1.72629260
128Macroorchidism (HP:0000053)1.72576760
129Abnormality of the calf musculature (HP:0001430)1.72266385
130Lower limb muscle weakness (HP:0007340)1.71504989
131Abnormality of the hip-girdle musculature (HP:0001445)1.71261852
132Abnormality of the musculature of the pelvis (HP:0001469)1.71261852
133Sclerocornea (HP:0000647)1.71134574
134Abnormality of the pubic bones (HP:0003172)1.70686409
135Broad-based gait (HP:0002136)1.70286856
136Ulnar claw (HP:0001178)1.69954593
137Abnormality of the aortic arch (HP:0012303)1.69723126
138Myotonia (HP:0002486)1.69367247
139Generalized tonic-clonic seizures (HP:0002069)1.68980170
140Lissencephaly (HP:0001339)1.68768948
141Recurrent skin infections (HP:0001581)1.68427524
142Progressive sensorineural hearing impairment (HP:0000408)1.68334842
143Absent phalangeal crease (HP:0006109)1.67836020
144Porencephaly (HP:0002132)1.66815610
145EEG with generalized epileptiform discharges (HP:0011198)1.66726160
146Severe muscular hypotonia (HP:0006829)1.65763700
147Acanthocytosis (HP:0001927)1.65171212
148Clumsiness (HP:0002312)1.65103645
149Muscle fiber splitting (HP:0003555)1.64844476
150Hypoplastic ischia (HP:0003175)1.64798588
151Septo-optic dysplasia (HP:0100842)1.64173787
152Abnormality of the frontal sinuses (HP:0002687)1.64122249
153Absence seizures (HP:0002121)1.63899912
154Agitation (HP:0000713)1.63895480
155Absent hand (HP:0004050)1.63292338
156Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.63183099
157Hypokalemia (HP:0002900)1.63089991
158Polymicrogyria (HP:0002126)1.62088699
159Elfin facies (HP:0004428)1.62064629
160Congenital hepatic fibrosis (HP:0002612)1.61075461
161Acute lymphatic leukemia (HP:0006721)1.60593499
162Pulmonary infiltrates (HP:0002113)1.60402096
163Abnormality of potassium homeostasis (HP:0011042)1.60303650
164EMG: myopathic abnormalities (HP:0003458)1.59753049
165Hyperphosphatemia (HP:0002905)1.59300495
166Epileptic encephalopathy (HP:0200134)1.58964554
167Hip dysplasia (HP:0001385)1.58713295
168Esotropia (HP:0000565)1.58246797
169Colitis (HP:0002583)1.57269831
170Short philtrum (HP:0000322)1.56773015
171Pheochromocytoma (HP:0002666)1.56658768
172Midline defect of the nose (HP:0004122)1.56097402
173Spastic paraplegia (HP:0001258)1.55816948
174Malignant hyperthermia (HP:0002047)1.55543095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.74970842
2MARK14.28896639
3FRK4.16143446
4STK38L4.04816828
5EPHB22.95763461
6EPHA32.77651668
7PINK12.76732409
8CHUK2.74354982
9MAP3K132.63294993
10SIK32.36810948
11BCR2.31160667
12ADRBK22.28277964
13LATS22.28277705
14WNK32.20719864
15PKN12.20181582
16IKBKB2.09933128
17CDK122.07108095
18KSR12.01385088
19OBSCN1.97861413
20DAPK21.96936854
21ERBB31.95939944
22DYRK21.94980242
23PRKAA21.92573524
24DYRK31.86124609
25MAP4K21.81691031
26TTN1.79812060
27ACVR1B1.76837884
28MAPK131.76284211
29PHKG11.75663906
30PHKG21.75663906
31SIK21.72999604
32NME11.66825654
33JAK31.65688841
34TYK21.61310459
35TNIK1.58030837
36GRK11.54244096
37BMPR1B1.54001736
38FGFR41.50738971
39NTRK31.41705069
40INSRR1.37812877
41FGFR31.37369237
42JAK11.35131370
43MAP2K71.34715429
44MAP3K41.32381780
45NTRK21.32043121
46CSNK1A1L1.10217184
47PRKD31.09949935
48IRAK41.09099712
49NUAK11.07078879
50IRAK11.05759703
51EPHB11.01398294
52MAP3K91.00574272
53EIF2AK21.00550013
54IKBKE1.00260211
55RET1.00181933
56SGK11.00081204
57TBK10.97976583
58CDC42BPA0.97636153
59STK30.97627872
60CASK0.96458143
61PRKCZ0.95864428
62DYRK1B0.95659201
63TLK10.95559206
64CCNB10.94648414
65CSNK1G20.93330406
66MAP2K40.92832278
67PTK60.91121515
68ICK0.90875719
69OXSR10.90697981
70EIF2AK30.88325390
71CSNK1G30.87536443
72DMPK0.85614154
73PAK30.83572512
74CSNK1G10.83135767
75TRIM280.82279236
76MAP2K60.81352741
77MAP3K70.77663152
78FLT30.77124353
79MAPKAPK30.74805519
80SGK20.73690338
81PRPF4B0.73204653
82TGFBR10.73201806
83DYRK1A0.70385215
84EPHA40.69801904
85MUSK0.69489023
86GRK70.67925002
87STK110.67487944
88PRKAA10.66151671
89FGFR20.66073163
90MKNK20.65353840
91BRD40.62091857
92IRAK20.61623016
93UHMK10.60921603
94RPS6KA10.60174785
95PIK3CG0.59394249
96AKT10.58973832
97CDK50.57685473
98ROCK10.56498089
99WNK40.55474540
100PRKCG0.55282739
101MAPKAPK20.55039707
102PAK60.54044812
103SGK2230.53303762
104SGK4940.53303762
105EEF2K0.52301179
106RPS6KA20.50703102
107STK380.49439461
108NLK0.48222105
109MINK10.47022515
110CAMK40.46731796
111CAMK2A0.45244099
112PRKCE0.44894023
113MAPK80.44781241
114SGK30.44302315
115YES10.44271160
116CDK30.43942753
117TAF10.43714959
118TNK20.43285314
119FGR0.42515498
120KIT0.42167770
121PRKACA0.41609770
122CSNK1D0.41383119
123SYK0.41175872
124LIMK10.40530918
125BMPR20.39889369
126CAMKK20.39820788
127TAOK30.39788763
128TYRO30.38829190
129MELK0.38078697
130AKT30.37681226
131WNK10.36770040
132MAP3K100.35568981
133PDGFRA0.35094896
134NEK20.35088844
135ROCK20.34749970
136CAMK10.34680732
137RPS6KA50.33489102
138CSNK1A10.31882883
139NEK90.31616966
140PRKCH0.31134185
141PTK20.30119508
142MAPK120.29976784
143PRKG10.29963110
144PLK20.28934764
145ZAK0.28331293
146GSK3B0.28293749
147GSK3A0.27944306
148CDK90.27445175
149ADRBK10.27422340
150TRPM70.27178381
151PRKCB0.26342580
152PTK2B0.26034014
153PRKACB0.25336036
154PRKCQ0.24369748
155TXK0.23918472
156LATS10.23905899
157MAP2K20.19471010

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.36809775
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.83450701
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.56758738
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48500180
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.38519016
6Butanoate metabolism_Homo sapiens_hsa006502.32103899
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09216314
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.07163439
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81438419
10Axon guidance_Homo sapiens_hsa043601.74891009
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.73888513
12Dilated cardiomyopathy_Homo sapiens_hsa054141.70518424
13TNF signaling pathway_Homo sapiens_hsa046681.69798286
14Apoptosis_Homo sapiens_hsa042101.64686586
15Viral myocarditis_Homo sapiens_hsa054161.63649226
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.61387209
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61271641
18Toxoplasmosis_Homo sapiens_hsa051451.60462924
19Calcium signaling pathway_Homo sapiens_hsa040201.55762740
20Tryptophan metabolism_Homo sapiens_hsa003801.51522966
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48897809
22Insulin secretion_Homo sapiens_hsa049111.47283938
23Prolactin signaling pathway_Homo sapiens_hsa049171.42860492
24Osteoclast differentiation_Homo sapiens_hsa043801.41884185
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39754638
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38713822
27Small cell lung cancer_Homo sapiens_hsa052221.33880729
28Leishmaniasis_Homo sapiens_hsa051401.33552814
29Chemokine signaling pathway_Homo sapiens_hsa040621.31946871
30Propanoate metabolism_Homo sapiens_hsa006401.31469149
31Circadian rhythm_Homo sapiens_hsa047101.31324491
32Linoleic acid metabolism_Homo sapiens_hsa005911.29748403
33MAPK signaling pathway_Homo sapiens_hsa040101.29391561
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29093832
35Type II diabetes mellitus_Homo sapiens_hsa049301.26019934
36Allograft rejection_Homo sapiens_hsa053301.22976318
37Protein export_Homo sapiens_hsa030601.22726028
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21915013
39Sphingolipid metabolism_Homo sapiens_hsa006001.19101641
40Chronic myeloid leukemia_Homo sapiens_hsa052201.18708666
41Autoimmune thyroid disease_Homo sapiens_hsa053201.14268828
42Oxidative phosphorylation_Homo sapiens_hsa001901.12713506
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09546387
44ErbB signaling pathway_Homo sapiens_hsa040121.08490033
45MicroRNAs in cancer_Homo sapiens_hsa052061.08380444
46Colorectal cancer_Homo sapiens_hsa052101.07031424
47Pancreatic cancer_Homo sapiens_hsa052121.06084281
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05920021
49Olfactory transduction_Homo sapiens_hsa047401.04813570
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04323387
51Oxytocin signaling pathway_Homo sapiens_hsa049211.04291551
52Endometrial cancer_Homo sapiens_hsa052131.04215125
53Ether lipid metabolism_Homo sapiens_hsa005651.03564108
54Parkinsons disease_Homo sapiens_hsa050121.03469967
55Antigen processing and presentation_Homo sapiens_hsa046121.03071649
56Cholinergic synapse_Homo sapiens_hsa047250.99658797
57Nicotine addiction_Homo sapiens_hsa050330.98719659
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98375760
59Dopaminergic synapse_Homo sapiens_hsa047280.97986399
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97698778
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.97000877
62Morphine addiction_Homo sapiens_hsa050320.96319864
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96210141
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95553924
65Primary immunodeficiency_Homo sapiens_hsa053400.95522076
66ABC transporters_Homo sapiens_hsa020100.95116491
67Measles_Homo sapiens_hsa051620.93518748
68Dorso-ventral axis formation_Homo sapiens_hsa043200.92641314
69Serotonergic synapse_Homo sapiens_hsa047260.91675677
70T cell receptor signaling pathway_Homo sapiens_hsa046600.91556077
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.91258331
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90065323
73Insulin resistance_Homo sapiens_hsa049310.89619958
74Basal transcription factors_Homo sapiens_hsa030220.89558027
75Salivary secretion_Homo sapiens_hsa049700.89374013
76Taste transduction_Homo sapiens_hsa047420.88751812
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87698268
78Glutamatergic synapse_Homo sapiens_hsa047240.87467846
79Hippo signaling pathway_Homo sapiens_hsa043900.85804934
80Nitrogen metabolism_Homo sapiens_hsa009100.85700339
81Acute myeloid leukemia_Homo sapiens_hsa052210.85234763
82p53 signaling pathway_Homo sapiens_hsa041150.84922144
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84726299
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84665533
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83938805
86FoxO signaling pathway_Homo sapiens_hsa040680.83730943
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83583501
88Long-term depression_Homo sapiens_hsa047300.83247458
89Renin secretion_Homo sapiens_hsa049240.82986251
90Epstein-Barr virus infection_Homo sapiens_hsa051690.82820920
91Pathways in cancer_Homo sapiens_hsa052000.82504407
92Ras signaling pathway_Homo sapiens_hsa040140.81921685
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81893252
94Tuberculosis_Homo sapiens_hsa051520.81834393
95GnRH signaling pathway_Homo sapiens_hsa049120.79695126
96Circadian entrainment_Homo sapiens_hsa047130.79491493
97Sulfur metabolism_Homo sapiens_hsa009200.78689112
98B cell receptor signaling pathway_Homo sapiens_hsa046620.77066641
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76968889
100Basal cell carcinoma_Homo sapiens_hsa052170.76862428
101Fatty acid degradation_Homo sapiens_hsa000710.76605576
102Graft-versus-host disease_Homo sapiens_hsa053320.76547984
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76521077
104Fanconi anemia pathway_Homo sapiens_hsa034600.76452577
105Adherens junction_Homo sapiens_hsa045200.74835190
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74528892
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74499517
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74331093
109Cardiac muscle contraction_Homo sapiens_hsa042600.74327575
110Insulin signaling pathway_Homo sapiens_hsa049100.73829950
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73094327
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72216597
113Alzheimers disease_Homo sapiens_hsa050100.72207450
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.70091047
115VEGF signaling pathway_Homo sapiens_hsa043700.70044122
116GABAergic synapse_Homo sapiens_hsa047270.69449371
117HTLV-I infection_Homo sapiens_hsa051660.68329646
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66915506
119Renal cell carcinoma_Homo sapiens_hsa052110.66833566
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66708983
121Influenza A_Homo sapiens_hsa051640.66149952
122Lysine degradation_Homo sapiens_hsa003100.65969470
123mTOR signaling pathway_Homo sapiens_hsa041500.65851509
124Cocaine addiction_Homo sapiens_hsa050300.63750665
125Choline metabolism in cancer_Homo sapiens_hsa052310.63680903
126Herpes simplex infection_Homo sapiens_hsa051680.63417899
127Regulation of autophagy_Homo sapiens_hsa041400.62797883
128Selenocompound metabolism_Homo sapiens_hsa004500.62427985
129Ovarian steroidogenesis_Homo sapiens_hsa049130.62362976
130Glioma_Homo sapiens_hsa052140.62266678
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61873370
132Shigellosis_Homo sapiens_hsa051310.61835212
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61410554
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58940610
135beta-Alanine metabolism_Homo sapiens_hsa004100.58809308
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57517144
137Asthma_Homo sapiens_hsa053100.57053532
138Wnt signaling pathway_Homo sapiens_hsa043100.56926976
139cAMP signaling pathway_Homo sapiens_hsa040240.56863069
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56834194
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56134598
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55762044
143Hepatitis B_Homo sapiens_hsa051610.55650523
144Melanogenesis_Homo sapiens_hsa049160.55587770
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55005399
146Gastric acid secretion_Homo sapiens_hsa049710.54940948
147Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53623901
148Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52916284
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52192264
150Fatty acid metabolism_Homo sapiens_hsa012120.51815189
151Peroxisome_Homo sapiens_hsa041460.48737237
152Glucagon signaling pathway_Homo sapiens_hsa049220.47063515
153Amphetamine addiction_Homo sapiens_hsa050310.46390126
154Type I diabetes mellitus_Homo sapiens_hsa049400.45288065
155Huntingtons disease_Homo sapiens_hsa050160.43938483
156Glycerolipid metabolism_Homo sapiens_hsa005610.43879781
157Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42620034
158Steroid hormone biosynthesis_Homo sapiens_hsa001400.42030329
159Synaptic vesicle cycle_Homo sapiens_hsa047210.40717356
160Homologous recombination_Homo sapiens_hsa034400.39928200
161Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35760505
162Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34359478
163AMPK signaling pathway_Homo sapiens_hsa041520.32173087
164Collecting duct acid secretion_Homo sapiens_hsa049660.31107194
165Adipocytokine signaling pathway_Homo sapiens_hsa049200.30617954
166Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30029666
167RNA degradation_Homo sapiens_hsa030180.27508153

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