SLCO4A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.11391428
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.82806755
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.82806755
4ribosomal small subunit assembly (GO:0000028)4.53182558
5positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.51344961
6regulation of gamma-delta T cell differentiation (GO:0045586)4.47753829
7regulation of vitamin D biosynthetic process (GO:0060556)4.46382932
8positive regulation by symbiont of host defense response (GO:0052509)4.36000585
9modulation by symbiont of host defense response (GO:0052031)4.36000585
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.36000585
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.36000585
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.36000585
13modulation by symbiont of host immune response (GO:0052553)4.36000585
14positive regulation of B cell differentiation (GO:0045579)4.34371233
15valine metabolic process (GO:0006573)4.32523189
16positive regulation of natural killer cell differentiation (GO:0032825)4.32348313
17positive regulation of prostaglandin secretion (GO:0032308)4.31393674
18regulation of gamma-delta T cell activation (GO:0046643)4.26106487
19protein maturation by protein folding (GO:0022417)4.26047433
20COPI coating of Golgi vesicle (GO:0048205)4.17350888
21Golgi transport vesicle coating (GO:0048200)4.17350888
22protein localization to endosome (GO:0036010)4.00097531
23antigen processing and presentation of endogenous antigen (GO:0019883)3.99022076
24regulation of cytokine secretion involved in immune response (GO:0002739)3.92981757
25negative regulation of erythrocyte differentiation (GO:0045647)3.92387518
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88451762
27definitive hemopoiesis (GO:0060216)3.83335305
28neutrophil activation involved in immune response (GO:0002283)3.78734834
29positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.75657013
30regulation of prostaglandin secretion (GO:0032306)3.72529724
31regulation of chronic inflammatory response (GO:0002676)3.71467701
32negative regulation of phagocytosis (GO:0050765)3.68967477
33regulation of podosome assembly (GO:0071801)3.66889538
34positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.57257909
35regulation of vitamin metabolic process (GO:0030656)3.54835551
36antigen processing and presentation via MHC class Ib (GO:0002475)3.53291073
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.51104354
38nuclear envelope reassembly (GO:0031468)3.47495622
39mitotic nuclear envelope reassembly (GO:0007084)3.47495622
40low-density lipoprotein particle clearance (GO:0034383)3.46794549
41mucosal-associated lymphoid tissue development (GO:0048537)3.45142639
42Peyers patch development (GO:0048541)3.45142639
43protein retention in ER lumen (GO:0006621)3.44526011
44regulation of membrane protein ectodomain proteolysis (GO:0051043)3.42218577
45skin morphogenesis (GO:0043589)3.37950807
46activation of MAPKKK activity (GO:0000185)3.36837107
47interleukin-1-mediated signaling pathway (GO:0070498)3.35818548
48lipopolysaccharide-mediated signaling pathway (GO:0031663)3.35426911
49positive regulation of icosanoid secretion (GO:0032305)3.34639491
50eosinophil chemotaxis (GO:0048245)3.33030200
51negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.29140326
52myeloid dendritic cell activation (GO:0001773)3.28602675
53barbed-end actin filament capping (GO:0051016)3.26353777
54activation of Rac GTPase activity (GO:0032863)3.26111883
55negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.21782711
56natural killer cell differentiation (GO:0001779)3.19562365
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.19322078
58response to host (GO:0075136)3.19322078
59response to host defenses (GO:0052200)3.19322078
60DNA unwinding involved in DNA replication (GO:0006268)3.18439171
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18318077
62glycosphingolipid catabolic process (GO:0046479)3.17623095
63positive regulation of chemokine biosynthetic process (GO:0045080)3.17393705
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.16855584
65regulation of B cell differentiation (GO:0045577)3.16532969
66myeloid dendritic cell differentiation (GO:0043011)3.15731500
67oligosaccharide catabolic process (GO:0009313)3.15286329
68positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.12502444
69positive regulation of macrophage activation (GO:0043032)3.10452506
70T cell homeostasis (GO:0043029)3.10092619
71cellular response to arsenic-containing substance (GO:0071243)3.09645039
72regulation of mononuclear cell migration (GO:0071675)3.07849010
73positive regulation of antigen processing and presentation (GO:0002579)3.07804256
74mature B cell differentiation involved in immune response (GO:0002313)3.07796127
75regulation of rhodopsin mediated signaling pathway (GO:0022400)3.07552209
76rhodopsin mediated signaling pathway (GO:0016056)3.07179845
77myeloid cell activation involved in immune response (GO:0002275)3.03486730
78response to muramyl dipeptide (GO:0032495)3.03004707
79positive regulation of Cdc42 GTPase activity (GO:0043089)3.02217554
80regulation of chemokine biosynthetic process (GO:0045073)2.99730636
81regulation of cholesterol storage (GO:0010885)2.98378220
82B cell receptor signaling pathway (GO:0050853)2.97916551
83negative regulation of nitric oxide biosynthetic process (GO:0045019)2.97063190
84establishment of viral latency (GO:0019043)2.96671528
85branching involved in mammary gland duct morphogenesis (GO:0060444)2.95435228
86respiratory burst (GO:0045730)2.94674226
87positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.94157900
88ncRNA 3-end processing (GO:0043628)2.93798769
89regulation of interferon-beta biosynthetic process (GO:0045357)2.90672097
90eosinophil migration (GO:0072677)2.89709164
91regulation of natural killer cell differentiation (GO:0032823)2.88777231
92megakaryocyte development (GO:0035855)2.88747961
93negative regulation of myeloid cell apoptotic process (GO:0033033)2.88463633
94neutrophil activation (GO:0042119)2.88211640
95membrane raft organization (GO:0031579)2.87443062
96granulocyte activation (GO:0036230)2.85537095
97macrophage activation involved in immune response (GO:0002281)2.85268869
98pyrimidine nucleoside salvage (GO:0043097)2.84482393
99pyrimidine-containing compound salvage (GO:0008655)2.84482393
100neutrophil mediated immunity (GO:0002446)2.81699482
101regulation of icosanoid secretion (GO:0032303)2.81361531
102regulation of superoxide anion generation (GO:0032928)2.80313910
103regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80264416
104cell adhesion mediated by integrin (GO:0033627)2.79597471
105cellular copper ion homeostasis (GO:0006878)2.79515234
106regulation of erythrocyte differentiation (GO:0045646)2.79254176
107response to peptidoglycan (GO:0032494)2.79126414
108mast cell activation (GO:0045576)2.78679775
109negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.78558128
110response to interferon-beta (GO:0035456)2.78183131
111dendritic cell differentiation (GO:0097028)2.77927991
112Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77671127
113regulation of B cell receptor signaling pathway (GO:0050855)2.76813722
114mature B cell differentiation (GO:0002335)2.76745309
115glycolipid catabolic process (GO:0019377)2.76267399
116response to progesterone (GO:0032570)2.74166169
117mitotic sister chromatid cohesion (GO:0007064)2.73398290
118positive regulation of fatty acid biosynthetic process (GO:0045723)2.73072346
119leukocyte degranulation (GO:0043299)2.71999478
120NIK/NF-kappaB signaling (GO:0038061)2.71961994
121positive regulation of fatty acid transport (GO:2000193)2.70847863
122hemidesmosome assembly (GO:0031581)2.69692434
123regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.66337141
124endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.65592068
125positive regulation of natural killer cell activation (GO:0032816)2.64419120
126regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61831456
127macrophage chemotaxis (GO:0048246)2.61251000
128leukocyte homeostasis (GO:0001776)2.60420814
129pinocytosis (GO:0006907)2.60011174
130lymphocyte homeostasis (GO:0002260)2.59641432
131response to host immune response (GO:0052572)2.58860004
132response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.58860004
133positive regulation of interleukin-1 beta secretion (GO:0050718)2.58710490
134regulation of cholesterol homeostasis (GO:2000188)2.58618964
135negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.58437418
136regulation of immunoglobulin secretion (GO:0051023)2.56430710
137positive regulation of interleukin-17 production (GO:0032740)2.55303556
138diaphragm development (GO:0060539)2.55074152
139monocyte chemotaxis (GO:0002548)2.54883588
140cellular response to virus (GO:0098586)2.54002914
141negative regulation of cell killing (GO:0031342)2.53844471
142negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.53844471
143positive regulation of interleukin-1 beta production (GO:0032731)2.53651837
144establishment of integrated proviral latency (GO:0075713)2.53453037
145nucleotide salvage (GO:0043173)2.52380617
146negative regulation of interleukin-12 production (GO:0032695)2.52349467
147modulation by symbiont of host cellular process (GO:0044068)2.51817936
148regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51803606
149B cell mediated immunity (GO:0019724)2.50240866
150negative regulation of viral release from host cell (GO:1902187)2.49684699
151lymph node development (GO:0048535)2.48824246
152decidualization (GO:0046697)2.48507433
153purine nucleotide salvage (GO:0032261)2.48216193
154glycolytic process (GO:0006096)2.48029304
155negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.47482654
156response to protozoan (GO:0001562)2.47376635
157positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.47362629
158fibrinolysis (GO:0042730)2.47220495
159establishment of endothelial barrier (GO:0061028)2.46521628
160positive regulation of erythrocyte differentiation (GO:0045648)2.45938827
161glucocorticoid receptor signaling pathway (GO:0042921)2.45755584
162myeloid leukocyte activation (GO:0002274)2.45280064
163GMP metabolic process (GO:0046037)2.45182794
164negative regulation of lipid storage (GO:0010888)2.44070781
165tRNA methylation (GO:0030488)2.43997871
166natural killer cell mediated cytotoxicity (GO:0042267)2.43976916
167natural killer cell mediated immunity (GO:0002228)2.43976916
168negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.43646078
169cellular response to nicotine (GO:0071316)2.43446407
170positive regulation of B cell activation (GO:0050871)2.43276452
171regulation of antigen processing and presentation (GO:0002577)2.43230802
172branching involved in labyrinthine layer morphogenesis (GO:0060670)2.42356527
173maturation of SSU-rRNA (GO:0030490)2.41931739
174regulation of necrotic cell death (GO:0010939)2.40539380
175regulation of interleukin-17 production (GO:0032660)2.40311228
176positive regulation of interferon-alpha production (GO:0032727)2.40175213
177mesodermal cell differentiation (GO:0048333)2.37866190
178glucose catabolic process (GO:0006007)2.37578709
179regulation of heterotypic cell-cell adhesion (GO:0034114)2.36503879
180substrate-dependent cell migration (GO:0006929)2.36484442
181sphingosine metabolic process (GO:0006670)2.36226349
182response to type I interferon (GO:0034340)2.35696411
183glucose 6-phosphate metabolic process (GO:0051156)2.35679725
184type I interferon signaling pathway (GO:0060337)2.35134112
185cellular response to type I interferon (GO:0071357)2.35134112
186retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.34367772
187positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.34111225
188regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.33967099
189mitotic chromosome condensation (GO:0007076)2.33236242
190endothelial cell chemotaxis (GO:0035767)2.31044091
191negative regulation of ERBB signaling pathway (GO:1901185)2.30421974
192nucleobase-containing small molecule interconversion (GO:0015949)2.29686429
193cellular protein complex localization (GO:0034629)2.28637076
194T-helper 1 type immune response (GO:0042088)2.28304680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.00883020
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.74519011
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.71686395
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.57205404
5SCL_19346495_ChIP-Seq_HPC-7_Human3.52942282
6ZNF263_19887448_ChIP-Seq_K562_Human3.42331108
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.36255804
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.34184952
9MYC_22102868_ChIP-Seq_BL_Human3.32114981
10VDR_21846776_ChIP-Seq_THP-1_Human3.21110638
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70840836
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.67876921
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.64008376
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.53142421
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50229935
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47414362
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45088258
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.43761540
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42462549
20VDR_24763502_ChIP-Seq_THP-1_Human2.42163060
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.39754287
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37787963
23* TCF7_22412390_ChIP-Seq_EML_Mouse2.36993739
24* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35419524
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28761556
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28688002
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20893804
28SPI1_23547873_ChIP-Seq_NB4_Human2.19757202
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.16855070
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.15759241
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13982520
32BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03085680
33* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00409543
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95728850
35UTX_26944678_Chip-Seq_JUKART_Human1.94352007
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92287344
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87857197
38* RACK7_27058665_Chip-Seq_MCF-7_Human1.87067432
39GATA1_22025678_ChIP-Seq_K562_Human1.87040574
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84604360
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83039725
42MAF_26560356_Chip-Seq_TH1_Human1.77943274
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76156399
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74052640
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73857234
46* MYB_26560356_Chip-Seq_TH2_Human1.72779958
47* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71157133
48RUNX_20019798_ChIP-Seq_JUKART_Human1.70869613
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69881318
50SPI1_23127762_ChIP-Seq_K562_Human1.66437353
51ATF3_27146783_Chip-Seq_COLON_Human1.66008470
52* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65654749
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65444051
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65405341
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.63994648
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63837790
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63334406
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59011378
59KDM2B_26808549_Chip-Seq_DND41_Human1.58458051
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.56063652
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56044117
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.54362587
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53721838
64CLOCK_20551151_ChIP-Seq_293T_Human1.53271252
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.53110131
66MYB_26560356_Chip-Seq_TH1_Human1.52685649
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.52550202
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51649139
69* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51147174
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47944716
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45898390
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44670126
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44088387
74PU_27001747_Chip-Seq_BMDM_Mouse1.41606885
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40202202
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.40199781
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39785794
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38680476
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38672896
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.38148451
81* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37276152
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.37068670
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36245190
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36048994
85CIITA_25753668_ChIP-Seq_RAJI_Human1.35951100
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32116587
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31374696
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30633477
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28787473
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28397321
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27555720
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25423448
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25051423
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24345909
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23998209
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23974094
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.23903086
98MAF_26560356_Chip-Seq_TH2_Human1.23765124
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23141950
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22958379
101DCP1A_22483619_ChIP-Seq_HELA_Human1.22911236
102TET1_21451524_ChIP-Seq_MESCs_Mouse1.21691126
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20776697
104SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20776697
105UBF1/2_26484160_Chip-Seq_HMECs_Human1.20250726
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17721978
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16950672
108P68_20966046_ChIP-Seq_HELA_Human1.16770227
109GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16313223
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14843253
111ESR1_21235772_ChIP-Seq_MCF-7_Human1.14384868
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13475032
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13033660
114P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12849613
115NCOR1_26117541_ChIP-Seq_K562_Human1.11140779
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11075537
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.11069884
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10362767
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09399937
120ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08662310
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08439837
122MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08430383
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07938764
124* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07065943
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06149154
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05897801
127BCOR_27268052_Chip-Seq_Bcells_Human1.05532539
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04090028
129THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02620656
130LXR_22292898_ChIP-Seq_THP-1_Human1.01775818
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01357922
132TFEB_21752829_ChIP-Seq_HELA_Human1.01024892
133SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00478537
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00414291
135HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99267961
136AR_21909140_ChIP-Seq_LNCAP_Human0.98687456
137* GATA3_27048872_Chip-Seq_THYMUS_Human0.98255010
138JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97898751
139BCL6_27268052_Chip-Seq_Bcells_Human0.97874291
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97452717
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96862165
142MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96791595
143ELF1_20517297_ChIP-Seq_JURKAT_Human0.96754601
144SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96278684
145FOXP3_21729870_ChIP-Seq_TREG_Human0.95226111
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94041602
147FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91896228
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.91752421
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90554521
150MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88489805
151VDR_24787735_ChIP-Seq_THP-1_Human0.86482582
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85721697
153MYC_19030024_ChIP-ChIP_MESCs_Mouse0.80376326
154PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79725247
155CTCF_27219007_Chip-Seq_ERYTHROID_Human0.78718866
156GATA2_21666600_ChIP-Seq_HMVEC_Human0.77429144
157CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75926809
158XRN2_22483619_ChIP-Seq_HELA_Human0.74712004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow4.35890130
2MP0005451_abnormal_body_composition3.25299445
3MP0001835_abnormal_antigen_presentation3.14792330
4MP0003300_gastrointestinal_ulcer2.89459415
5MP0001545_abnormal_hematopoietic_system2.82300465
6MP0005397_hematopoietic_system_phenotyp2.82300465
7MP0000685_abnormal_immune_system2.80558414
8MP0003436_decreased_susceptibility_to2.78999541
9MP0004808_abnormal_hematopoietic_stem2.53481723
10MP0003303_peritoneal_inflammation2.42180807
11MP0002419_abnormal_innate_immunity2.37623113
12MP0000465_gastrointestinal_hemorrhage2.36202179
13MP0009785_altered_susceptibility_to2.28257564
14MP0001873_stomach_inflammation2.25759029
15MP0005025_abnormal_response_to2.24678807
16MP0001800_abnormal_humoral_immune2.23143032
17MP0005464_abnormal_platelet_physiology2.22019744
18MP0002396_abnormal_hematopoietic_system2.21589881
19MP0002452_abnormal_antigen_presenting2.19965282
20MP0005076_abnormal_cell_differentiation2.17117741
21MP0002723_abnormal_immune_serum2.08732304
22MP0003806_abnormal_nucleotide_metabolis2.04492127
23MP0001819_abnormal_immune_cell2.04371601
24MP0002420_abnormal_adaptive_immunity2.03673450
25MP0005671_abnormal_response_to2.03654897
26MP0005257_abnormal_intraocular_pressure2.03518176
27MP0002398_abnormal_bone_marrow2.01812922
28MP0010155_abnormal_intestine_physiology2.01486794
29MP0005000_abnormal_immune_tolerance2.01316948
30MP0009333_abnormal_splenocyte_physiolog1.99909952
31MP0010234_abnormal_vibrissa_follicle1.97787698
32MP0002332_abnormal_exercise_endurance1.90634088
33MP0000689_abnormal_spleen_morphology1.84905673
34MP0010307_abnormal_tumor_latency1.82139038
35MP0001790_abnormal_immune_system1.81130001
36MP0005387_immune_system_phenotype1.81130001
37MP0003011_delayed_dark_adaptation1.77435516
38MP0002722_abnormal_immune_system1.77023223
39MP0002148_abnormal_hypersensitivity_rea1.73806160
40MP0005058_abnormal_lysosome_morphology1.72337394
41MP0000716_abnormal_immune_system1.71156580
42MP0003763_abnormal_thymus_physiology1.70416838
43MP0004185_abnormal_adipocyte_glucose1.68293928
44MP0000566_synostosis1.66831653
45MP0002405_respiratory_system_inflammati1.66269579
46MP0000490_abnormal_crypts_of1.64854186
47MP0003693_abnormal_embryo_hatching1.64449305
48MP0005551_abnormal_eye_electrophysiolog1.62954555
49MP0000703_abnormal_thymus_morphology1.62886042
50MP0002796_impaired_skin_barrier1.62784492
51MP0003123_paternal_imprinting1.59348521
52MP0001845_abnormal_inflammatory_respons1.58479234
53MP0005165_increased_susceptibility_to1.57062309
54MP0002166_altered_tumor_susceptibility1.56706091
55MP0002429_abnormal_blood_cell1.55644799
56MP0000569_abnormal_digit_pigmentation1.55604291
57MP0004947_skin_inflammation1.53397212
58MP0003866_abnormal_defecation1.53198929
59MP0008260_abnormal_autophagy1.53117232
60MP0005166_decreased_susceptibility_to1.52345435
61MP0009764_decreased_sensitivity_to1.51561368
62MP0000858_altered_metastatic_potential1.49997166
63MP0005501_abnormal_skin_physiology1.49538252
64MP0003448_altered_tumor_morphology1.48291342
65MP0003172_abnormal_lysosome_physiology1.48003898
66MP0010352_gastrointestinal_tract_polyps1.47556663
67MP0003329_amyloid_beta_deposits1.46261062
68MP0001853_heart_inflammation1.45184160
69MP0004233_abnormal_muscle_weight1.43112939
70MP0002139_abnormal_hepatobiliary_system1.40722942
71MP0004510_myositis1.38904741
72MP0001216_abnormal_epidermal_layer1.34949953
73MP0009840_abnormal_foam_cell1.34295914
74MP0003705_abnormal_hypodermis_morpholog1.34200850
75MP0003656_abnormal_erythrocyte_physiolo1.33219633
76MP0001533_abnormal_skeleton_physiology1.32374378
77MP0001849_ear_inflammation1.32154474
78MP0002877_abnormal_melanocyte_morpholog1.32139368
79MP0003191_abnormal_cellular_cholesterol1.31930094
80MP0003566_abnormal_cell_adhesion1.31619326
81MP0004858_abnormal_nervous_system1.30336570
82MP0005174_abnormal_tail_pigmentation1.28909645
83MP0005253_abnormal_eye_physiology1.28680949
84MP0006082_CNS_inflammation1.27901064
85MP0002006_tumorigenesis1.27714507
86MP0005023_abnormal_wound_healing1.23525510
87MP0008057_abnormal_DNA_replication1.21889723
88MP0003091_abnormal_cell_migration1.21159718
89MP0005666_abnormal_adipose_tissue1.19423278
90MP0003077_abnormal_cell_cycle1.16422422
91MP0003724_increased_susceptibility_to1.16109321
92MP0002060_abnormal_skin_morphology1.09059412
93MP0002019_abnormal_tumor_incidence1.08942438
94MP0001764_abnormal_homeostasis1.08360993
95MP0008469_abnormal_protein_level1.08346809
96MP0001851_eye_inflammation1.08091497
97MP0005310_abnormal_salivary_gland1.05833840
98MP0000751_myopathy1.01472864
99MP0003315_abnormal_perineum_morphology1.00315302
100MP0000343_altered_response_to0.99551632
101MP0000750_abnormal_muscle_regeneration0.98833962
102MP0001915_intracranial_hemorrhage0.96257659
103MP0002933_joint_inflammation0.95210393
104MP0006072_abnormal_retinal_apoptosis0.94642422
105MP0005375_adipose_tissue_phenotype0.94605025
106MP0005167_abnormal_blood-brain_barrier0.91916249
107MP0000678_abnormal_parathyroid_gland0.90573110
108MP0005164_abnormal_response_to0.90291263
109MP0002254_reproductive_system_inflammat0.89408711
110MP0005197_abnormal_uvea_morphology0.87688947
111MP0000358_abnormal_cell_content/0.87511093
112MP0000313_abnormal_cell_death0.87162719
113MP0004883_abnormal_blood_vessel0.85622907
114MP0001663_abnormal_digestive_system0.84286893
115MP0000749_muscle_degeneration0.83066912
116MP0001324_abnormal_eye_pigmentation0.82826963
117MP0003111_abnormal_nucleus_morphology0.80645330
118MP0005330_cardiomyopathy0.79682012
119MP0010094_abnormal_chromosome_stability0.79376856
120MP0000604_amyloidosis0.79344800
121MP0005670_abnormal_white_adipose0.78554190
122MP0003950_abnormal_plasma_membrane0.78418134
123MP0000467_abnormal_esophagus_morphology0.76270147
124MP0001986_abnormal_taste_sensitivity0.75312056
125MP0000579_abnormal_nail_morphology0.74916534
126MP0010678_abnormal_skin_adnexa0.74043523
127MP0003075_altered_response_to0.72915915
128MP0002998_abnormal_bone_remodeling0.72718186
129MP0000733_abnormal_muscle_development0.71421495
130MP0004272_abnormal_basement_membrane0.71263464
131MP0000537_abnormal_urethra_morphology0.70477636
132MP0000003_abnormal_adipose_tissue0.69486278
133MP0004264_abnormal_extraembryonic_tissu0.68498139
134MP0010771_integument_phenotype0.68420684
135MP0005391_vision/eye_phenotype0.67360630
136MP0008007_abnormal_cellular_replicative0.67331898
137MP0004957_abnormal_blastocyst_morpholog0.67283468
138MP0000747_muscle_weakness0.66651700
139MP0005390_skeleton_phenotype0.66478483
140MP0000383_abnormal_hair_follicle0.66217561
141MP0000350_abnormal_cell_proliferation0.65109932
142MP0003453_abnormal_keratinocyte_physiol0.65035196
143MP0008004_abnormal_stomach_pH0.64614042
144MP0003828_pulmonary_edema0.63918122
145MP0005621_abnormal_cell_physiology0.62229627
146MP0005195_abnormal_posterior_eye0.61821089

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.29733746
2Abnormality of liposaccharide metabolism (HP:0010968)5.22636943
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.22636943
4Abnormality of glycolipid metabolism (HP:0010969)5.22636943
5Thrombocytosis (HP:0001894)4.87416406
6Interstitial pulmonary disease (HP:0006530)4.69128892
7Absent rod-and cone-mediated responses on ERG (HP:0007688)4.62990277
8Bony spicule pigmentary retinopathy (HP:0007737)4.43023074
9Recurrent abscess formation (HP:0002722)4.34837439
10Abnormal rod and cone electroretinograms (HP:0008323)4.31130060
11Recurrent bacterial skin infections (HP:0005406)4.18909049
12Axonal loss (HP:0003447)4.12399082
13Elevated erythrocyte sedimentation rate (HP:0003565)3.99363330
14Pendular nystagmus (HP:0012043)3.92746707
15Eczematoid dermatitis (HP:0000976)3.77489698
16Pigmentary retinal degeneration (HP:0001146)3.70880382
17Vacuolated lymphocytes (HP:0001922)3.63532789
18Nuclear cataract (HP:0100018)3.61990551
19Cellulitis (HP:0100658)3.47414466
20Myositis (HP:0100614)3.45218112
21Chorioretinal atrophy (HP:0000533)3.34123274
22Neurofibrillary tangles (HP:0002185)3.29572375
23Vertebral compression fractures (HP:0002953)3.28001820
24Loss of speech (HP:0002371)3.20547693
25Reduced subcutaneous adipose tissue (HP:0003758)3.18649364
26Impaired platelet aggregation (HP:0003540)3.16708907
27Abnormal platelet function (HP:0011869)3.16708907
28Increased cerebral lipofuscin (HP:0011813)3.15928369
29Distal lower limb amyotrophy (HP:0008944)3.14260858
30Increased neuronal autofluorescent lipopigment (HP:0002074)3.04821298
31Progressive muscle weakness (HP:0003323)3.00378694
32High pitched voice (HP:0001620)2.98613435
33Distal lower limb muscle weakness (HP:0009053)2.96772153
34Centrally nucleated skeletal muscle fibers (HP:0003687)2.95050350
35Amyloidosis (HP:0011034)2.89070550
36Poor head control (HP:0002421)2.86786430
37Cerebral inclusion bodies (HP:0100314)2.86786048
38IgM deficiency (HP:0002850)2.86571048
39Hyperacusis (HP:0010780)2.84991520
40Nonprogressive disorder (HP:0003680)2.82258734
41Petechiae (HP:0000967)2.82096652
42Chronic otitis media (HP:0000389)2.82085965
43Abolished electroretinogram (ERG) (HP:0000550)2.76962606
44Recurrent fungal infections (HP:0002841)2.76568682
45Spondylolisthesis (HP:0003302)2.72982218
46Achilles tendon contracture (HP:0001771)2.72839916
47Stomatitis (HP:0010280)2.72701186
48Cholecystitis (HP:0001082)2.67623928
49Abnormal gallbladder physiology (HP:0012438)2.67623928
50Abnormality of the fingertips (HP:0001211)2.67529826
51Myocardial infarction (HP:0001658)2.65487721
52Apathy (HP:0000741)2.60792988
53Poikiloderma (HP:0001029)2.59205320
54J-shaped sella turcica (HP:0002680)2.58115491
55Attenuation of retinal blood vessels (HP:0007843)2.55967966
56Abnormality of the distal phalanges of the toes (HP:0010182)2.54986837
57Increased connective tissue (HP:0009025)2.54706590
58Short nail (HP:0001799)2.54586985
59Abnormality of macrophages (HP:0004311)2.54515182
60Periodontitis (HP:0000704)2.53745090
61Supranuclear gaze palsy (HP:0000605)2.52694487
62Aortic aneurysm (HP:0004942)2.52552101
63Recurrent viral infections (HP:0004429)2.52187608
64Mediastinal lymphadenopathy (HP:0100721)2.51475659
65Hypokinesia (HP:0002375)2.51145058
66Chronic obstructive pulmonary disease (HP:0006510)2.51008627
67Obstructive lung disease (HP:0006536)2.51008627
68Deep venous thrombosis (HP:0002625)2.45347254
69Upper limb amyotrophy (HP:0009129)2.45182355
70Distal upper limb amyotrophy (HP:0007149)2.45182355
71Macular degeneration (HP:0000608)2.44564829
72Diminished motivation (HP:0000745)2.43442788
73Abnormality of the Achilles tendon (HP:0005109)2.43243096
74Restrictive lung disease (HP:0002091)2.42809725
75Weak cry (HP:0001612)2.42736854
76Recurrent skin infections (HP:0001581)2.42201562
77Ragged-red muscle fibers (HP:0003200)2.41017627
78Pustule (HP:0200039)2.38943340
79Gingivitis (HP:0000230)2.38775229
80Trismus (HP:0000211)2.38559219
81Neuronal loss in central nervous system (HP:0002529)2.35098330
82Abnormality of macular pigmentation (HP:0008002)2.34793939
83Upper motor neuron abnormality (HP:0002127)2.33733224
84Dyschromatopsia (HP:0007641)2.33325311
85Osteomyelitis (HP:0002754)2.31195361
86Insomnia (HP:0100785)2.30720909
87Upper limb muscle weakness (HP:0003484)2.29902769
88Meningitis (HP:0001287)2.28274833
89Photophobia (HP:0000613)2.25646329
90Difficulty climbing stairs (HP:0003551)2.23142393
91Broad face (HP:0000283)2.23080222
92Increased serum ferritin (HP:0003281)2.23061837
93Rough bone trabeculation (HP:0100670)2.22289388
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22070686
95Disinhibition (HP:0000734)2.21998636
96Generalized amyotrophy (HP:0003700)2.21161849
97Thyroiditis (HP:0100646)2.20971977
98Aplastic anemia (HP:0001915)2.16865652
99Chest pain (HP:0100749)2.16030778
100Constricted visual fields (HP:0001133)2.15254403
101Inflammation of the large intestine (HP:0002037)2.13970303
102Prolonged bleeding time (HP:0003010)2.13872362
103Lymphopenia (HP:0001888)2.13713885
104Osteolytic defects of the phalanges of the hand (HP:0009771)2.13700404
105Osteolytic defects of the hand bones (HP:0009699)2.13700404
106Prolonged neonatal jaundice (HP:0006579)2.12665188
107Gastrointestinal inflammation (HP:0004386)2.10958570
108Abnormal trabecular bone morphology (HP:0100671)2.10000800
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09781219
110Abnormality of polysaccharide metabolism (HP:0011012)2.09781219
111Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09781219
112Abnormality of cells of the lymphoid lineage (HP:0012140)2.09218819
113Leukocytosis (HP:0001974)2.07280147
114Epistaxis (HP:0000421)2.06269484
115Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05228760
116Increased IgE level (HP:0003212)2.04633453
117Nail dystrophy (HP:0008404)2.04623830
118Aplasia cutis congenita (HP:0001057)2.04475583
119Type II diabetes mellitus (HP:0005978)2.04220405
120Hemorrhage of the eye (HP:0011885)2.04090137
121Colitis (HP:0002583)2.03859262
122Agnosia (HP:0010524)2.03588939
123Progressive neurologic deterioration (HP:0002344)2.03442998
124Lower limb amyotrophy (HP:0007210)2.03203711
125Decreased central vision (HP:0007663)2.03082637
126Fatigue (HP:0012378)2.01500880
127Recurrent gram-negative bacterial infections (HP:0005420)2.00905973
128Reticulocytopenia (HP:0001896)1.99897015
129Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.99675465
130Hepatosplenomegaly (HP:0001433)1.99039658
131Severe visual impairment (HP:0001141)1.98689513
132Orchitis (HP:0100796)1.98274534
133Diaphragmatic weakness (HP:0009113)1.98210873
134Pulmonary infiltrates (HP:0002113)1.97376940
135Papilledema (HP:0001085)1.96651773
136Glucose intolerance (HP:0000833)1.95430968
137Mucopolysacchariduria (HP:0008155)1.94546797
138Urinary glycosaminoglycan excretion (HP:0003541)1.94546797
139Abnormality of cells of the erythroid lineage (HP:0012130)1.94335231
140Polygenic inheritance (HP:0010982)1.93331209
141Abnormal delayed hypersensitivity skin test (HP:0002963)1.93100976
142Recurrent bronchitis (HP:0002837)1.92537181
143Volvulus (HP:0002580)1.92450894
144Natal tooth (HP:0000695)1.92149681
145Urticaria (HP:0001025)1.91926387
146Increased density of long bones (HP:0006392)1.91016637
147Nasal polyposis (HP:0100582)1.90719605
148Dysostosis multiplex (HP:0000943)1.90152782
149Arterial thrombosis (HP:0004420)1.90107882
150Pallor (HP:0000980)1.89897646
151Abnormality of the nasal mucosa (HP:0000433)1.89624526
152Spontaneous hematomas (HP:0007420)1.89211268
153Progressive visual loss (HP:0000529)1.88836768
154Central scotoma (HP:0000603)1.88268513
155Acute lymphatic leukemia (HP:0006721)1.87897909
156Vasculitis (HP:0002633)1.86869952
157Personality changes (HP:0000751)1.86532672
158Segmental peripheral demyelination/remyelination (HP:0003481)1.86205042
159Gingival bleeding (HP:0000225)1.85725851
160Acute myeloid leukemia (HP:0004808)1.85410413
161Emphysema (HP:0002097)1.84365805
162Systemic lupus erythematosus (HP:0002725)1.82952510
163Abnormality of the prostate (HP:0008775)1.82796969
164Bone pain (HP:0002653)1.82791451
165Thoracic kyphosis (HP:0002942)1.82553724
166Hypergammaglobulinemia (HP:0010702)1.79819065
167Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78799780
168Sparse eyelashes (HP:0000653)1.78040171
169Scotoma (HP:0000575)1.77020619
170Vascular calcification (HP:0004934)1.76585493
171Premature rupture of membranes (HP:0001788)1.75870909
172Aplasia/Hypoplasia of the spleen (HP:0010451)1.75799158
173Ureteral duplication (HP:0000073)1.74071129
174Abnormality of glycolysis (HP:0004366)1.73555776
175Right ventricular cardiomyopathy (HP:0011663)1.73093489
176Purpura (HP:0000979)1.71498012
177Congenital ichthyosiform erythroderma (HP:0007431)1.70958269
178Hand muscle atrophy (HP:0009130)1.69525983
179Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.69509937
180Ureteral stenosis (HP:0000071)1.69489819
181Pathologic fracture (HP:0002756)1.68361209
182Entropion (HP:0000621)1.66587875
183Plantar hyperkeratosis (HP:0007556)1.66543027
184Hyperparathyroidism (HP:0000843)1.64602187
185Deviation of the thumb (HP:0009603)1.62194491
186Cardiomegaly (HP:0001640)1.61914568
187Dementia (HP:0000726)1.60902587
188Abnormal blistering of the skin (HP:0008066)1.60228635
189Onycholysis (HP:0001806)1.59768054
190Multiple lipomas (HP:0001012)1.59618641
191Elbow flexion contracture (HP:0002987)1.58789820
192Focal segmental glomerulosclerosis (HP:0000097)1.58771582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.30800108
2MAP3K44.39316054
3MST1R4.07011545
4MAP2K74.05382342
5TAOK23.66124809
6EEF2K3.13734782
7MAP4K12.97447117
8PKN22.66914030
9LMTK22.47216988
10CAMK1D2.46017867
11CDK32.41589882
12KIT2.38105233
13TESK22.25318046
14PIM22.24129562
15BTK2.19275304
16TESK12.13857187
17CAMK1G2.10761286
18MAP2K42.01827943
19ICK1.95196631
20PRPF4B1.82528511
21JAK31.80051839
22RPS6KB21.78897151
23TYK21.77961478
24ARAF1.77652207
25CSF1R1.73423719
26TBK11.67537977
27BLK1.67305923
28SIK11.60512002
29ERN11.59821867
30WNK31.58572706
31SYK1.57572004
32FLT31.54996920
33NME21.54072519
34CAMKK21.53481235
35MET1.53141863
36ABL21.52013020
37RET1.50248672
38SMG11.49133526
39ZAP701.48144374
40PTK61.47876549
41TAOK31.43747627
42MOS1.41730013
43CDK121.40517850
44MAP3K101.38781767
45FES1.34798261
46TRIB31.31780009
47HCK1.30770279
48MUSK1.23977445
49LIMK11.21252757
50IKBKE1.21225943
51BUB11.20950461
52TGFBR21.20747817
53IRAK41.19570730
54MAP2K31.17382055
55STK161.16335421
56MAP3K141.14958451
57TEC1.12724585
58IKBKB1.11139190
59VRK21.10379087
60ITK1.07567206
61LRRK21.04631473
62GRK71.04579834
63STK101.03673882
64LATS21.02818309
65NEK21.00728127
66TXK1.00722330
67DDR21.00439841
68PIM10.97452037
69RPS6KA40.96573888
70GRK10.96487343
71ALK0.95931580
72PTK20.94574463
73MAP3K10.91290129
74TRPM70.90027531
75LCK0.88853566
76PBK0.88383187
77MKNK20.88136704
78ERBB40.87179081
79MELK0.82470196
80LYN0.82080213
81IRAK30.81561017
82JAK10.81280183
83DAPK10.80420882
84MAPK40.79174456
85CDK40.77556819
86HIPK20.76848475
87PAK40.76444034
88IRAK20.75612442
89MAP3K80.74443163
90JAK20.73817542
91CDK80.73660235
92ATR0.70049678
93EPHB10.69497775
94CAMKK10.68938219
95SCYL20.66434011
96PRKG20.64291443
97CDC70.60154971
98MAPKAPK30.59078273
99BRAF0.58267437
100CDK60.57705011
101CHUK0.57074788
102GRK60.56115841
103CDK90.55002386
104PDGFRA0.54084610
105PHKG20.53983555
106PHKG10.53983555
107SIK20.53774578
108NEK10.51647019
109MATK0.50958611
110CSK0.50719606
111BRSK10.50631893
112AURKA0.50382919
113FGFR30.50129769
114MAP3K50.49101968
115MAP3K90.48784019
116EIF2AK30.48381315
117BRD40.48338876
118MAP3K110.48013031
119TTN0.45279120
120PDK10.45140761
121CAMK10.45080369
122RPS6KA20.44573596
123MAPKAPK20.43982169
124MTOR0.43761289
125MAP3K70.43663362
126CSNK1A1L0.41837770
127MAPK110.41748938
128CDC42BPA0.41647725
129TGFBR10.41624845
130MAP3K30.40072304
131MKNK10.38455108
132PAK10.37256739
133EGFR0.37253456
134CDK70.37072998
135EIF2AK20.36756893
136ABL10.36350317
137FGFR40.35296472
138EIF2AK10.34374863
139PASK0.33837174
140RPS6KA60.33650449
141TAOK10.33570602
142PRKCI0.33306688
143RPS6KB10.33281721
144RIPK10.33090232
145MAP3K130.32737964
146BMX0.32681915
147RIPK40.32575891
148SIK30.30520116
149GSK3A0.29937425
150CDK11A0.27310446
151CDK150.26205266
152CHEK20.25380310
153CAMK2G0.25185137
154SRPK10.23822845
155PDK20.23656675
156CDK140.23510030
157FGR0.23252037
158CDK180.23119279
159DAPK30.22921210
160PDPK10.20194101
161CCNB10.20055163
162NTRK10.19812755
163MAP2K60.16976177

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.65426030
2B cell receptor signaling pathway_Homo sapiens_hsa046622.42510939
3Osteoclast differentiation_Homo sapiens_hsa043802.40874823
4Leishmaniasis_Homo sapiens_hsa051402.26130629
5Fructose and mannose metabolism_Homo sapiens_hsa000512.22193777
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.11441746
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.04049169
8Galactose metabolism_Homo sapiens_hsa000522.03788816
9DNA replication_Homo sapiens_hsa030302.02401120
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.97026597
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.95155001
12Bladder cancer_Homo sapiens_hsa052191.94699792
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94601874
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.87694755
15Pertussis_Homo sapiens_hsa051331.74234838
16Pentose phosphate pathway_Homo sapiens_hsa000301.72739470
17Other glycan degradation_Homo sapiens_hsa005111.68850073
18Herpes simplex infection_Homo sapiens_hsa051681.67940386
19Proteasome_Homo sapiens_hsa030501.67688815
20Primary immunodeficiency_Homo sapiens_hsa053401.66463995
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60238282
22Biosynthesis of amino acids_Homo sapiens_hsa012301.59478307
23Hepatitis B_Homo sapiens_hsa051611.55936815
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53021826
25TNF signaling pathway_Homo sapiens_hsa046681.52109828
26Apoptosis_Homo sapiens_hsa042101.50466022
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49417585
28Shigellosis_Homo sapiens_hsa051311.46885171
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46752129
30Sulfur relay system_Homo sapiens_hsa041221.46176074
31Antigen processing and presentation_Homo sapiens_hsa046121.45122101
32Pancreatic cancer_Homo sapiens_hsa052121.44933725
33Mismatch repair_Homo sapiens_hsa034301.43529508
34Chronic myeloid leukemia_Homo sapiens_hsa052201.43097412
35Acute myeloid leukemia_Homo sapiens_hsa052211.42933529
36Prion diseases_Homo sapiens_hsa050201.42724197
37Measles_Homo sapiens_hsa051621.42488700
38Toxoplasmosis_Homo sapiens_hsa051451.42406342
39Vibrio cholerae infection_Homo sapiens_hsa051101.40086932
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39242138
41Tuberculosis_Homo sapiens_hsa051521.37013578
42Influenza A_Homo sapiens_hsa051641.34493436
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33960201
44T cell receptor signaling pathway_Homo sapiens_hsa046601.33636770
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31458318
46Folate biosynthesis_Homo sapiens_hsa007901.28925643
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27702916
48Hematopoietic cell lineage_Homo sapiens_hsa046401.26727913
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24786657
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21849181
51Salmonella infection_Homo sapiens_hsa051321.19870164
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.17490964
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.16414674
54Platelet activation_Homo sapiens_hsa046111.13021055
55Colorectal cancer_Homo sapiens_hsa052101.11979403
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.10360002
57Malaria_Homo sapiens_hsa051441.09673927
58Legionellosis_Homo sapiens_hsa051341.08215376
59Prolactin signaling pathway_Homo sapiens_hsa049171.08177163
60Pyrimidine metabolism_Homo sapiens_hsa002401.07155238
61Carbon metabolism_Homo sapiens_hsa012001.06367514
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06219523
63Lysosome_Homo sapiens_hsa041421.03361498
64Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03147830
65Staphylococcus aureus infection_Homo sapiens_hsa051501.02565337
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02555005
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01637800
68Ribosome_Homo sapiens_hsa030101.00698713
69Asthma_Homo sapiens_hsa053100.96464214
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.96023467
71Notch signaling pathway_Homo sapiens_hsa043300.95603619
72Base excision repair_Homo sapiens_hsa034100.95091503
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.92138687
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89538908
75Epstein-Barr virus infection_Homo sapiens_hsa051690.87739032
76HTLV-I infection_Homo sapiens_hsa051660.86975308
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86093610
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84702239
79Fatty acid elongation_Homo sapiens_hsa000620.84043909
80Sphingolipid metabolism_Homo sapiens_hsa006000.83714111
81Cell cycle_Homo sapiens_hsa041100.83444555
82Chemokine signaling pathway_Homo sapiens_hsa040620.82379254
83Hepatitis C_Homo sapiens_hsa051600.81264506
84Vitamin B6 metabolism_Homo sapiens_hsa007500.80211642
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79049745
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76750570
87p53 signaling pathway_Homo sapiens_hsa041150.76373037
88Viral carcinogenesis_Homo sapiens_hsa052030.75632909
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.75349041
90Rheumatoid arthritis_Homo sapiens_hsa053230.74871122
91Fatty acid biosynthesis_Homo sapiens_hsa000610.73573358
92Amoebiasis_Homo sapiens_hsa051460.72562247
93Non-small cell lung cancer_Homo sapiens_hsa052230.72507613
94Melanoma_Homo sapiens_hsa052180.70472118
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.69887008
96HIF-1 signaling pathway_Homo sapiens_hsa040660.69824637
97Viral myocarditis_Homo sapiens_hsa054160.69641429
98VEGF signaling pathway_Homo sapiens_hsa043700.68710370
99FoxO signaling pathway_Homo sapiens_hsa040680.67440254
100MicroRNAs in cancer_Homo sapiens_hsa052060.66547001
101Homologous recombination_Homo sapiens_hsa034400.66251592
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65797891
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65383617
104Type II diabetes mellitus_Homo sapiens_hsa049300.64179649
105Non-homologous end-joining_Homo sapiens_hsa034500.64076711
106African trypanosomiasis_Homo sapiens_hsa051430.63907210
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63378308
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.63316916
109Small cell lung cancer_Homo sapiens_hsa052220.62233534
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61810392
111Phagosome_Homo sapiens_hsa041450.60251492
112Choline metabolism in cancer_Homo sapiens_hsa052310.59473113
113Systemic lupus erythematosus_Homo sapiens_hsa053220.57925418
114Glutathione metabolism_Homo sapiens_hsa004800.56818124
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56484101
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56190721
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55895374
118mTOR signaling pathway_Homo sapiens_hsa041500.55705278
119Allograft rejection_Homo sapiens_hsa053300.54746514
120Spliceosome_Homo sapiens_hsa030400.54235292
121MAPK signaling pathway_Homo sapiens_hsa040100.53325758
122Proteoglycans in cancer_Homo sapiens_hsa052050.53211995
123Complement and coagulation cascades_Homo sapiens_hsa046100.53020374
124N-Glycan biosynthesis_Homo sapiens_hsa005100.51699071
125Endocytosis_Homo sapiens_hsa041440.50324372
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49374301
127Insulin resistance_Homo sapiens_hsa049310.48930951
128Pathways in cancer_Homo sapiens_hsa052000.47270886
129Inositol phosphate metabolism_Homo sapiens_hsa005620.46143948
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.45656412
131RNA polymerase_Homo sapiens_hsa030200.44560595
132Thyroid cancer_Homo sapiens_hsa052160.43966780
133Basal transcription factors_Homo sapiens_hsa030220.41707181
134ErbB signaling pathway_Homo sapiens_hsa040120.41654530
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40434872
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40432090
137Nucleotide excision repair_Homo sapiens_hsa034200.38331223
138Insulin signaling pathway_Homo sapiens_hsa049100.36603685
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34756044
140Salivary secretion_Homo sapiens_hsa049700.34551694

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