SLCO2A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)5.52201842
2glucocorticoid biosynthetic process (GO:0006704)5.20017709
3hemidesmosome assembly (GO:0031581)4.72404276
4regulation of transforming growth factor beta2 production (GO:0032909)4.43814495
5regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.39934721
6regulation of cardioblast differentiation (GO:0051890)4.38344509
7fibroblast migration (GO:0010761)4.37574154
8chemical homeostasis within a tissue (GO:0048875)4.33146183
9negative regulation of fibrinolysis (GO:0051918)4.00274558
10glucocorticoid metabolic process (GO:0008211)3.99830089
11glomerular filtration (GO:0003094)3.89603012
12positive regulation of astrocyte differentiation (GO:0048711)3.87794673
13positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.84532932
14peptidyl-glutamic acid carboxylation (GO:0017187)3.84084636
15protein carboxylation (GO:0018214)3.84084636
16complement activation, alternative pathway (GO:0006957)3.77387745
17regulation of fibrinolysis (GO:0051917)3.71847070
18adhesion of symbiont to host (GO:0044406)3.70476823
19L-phenylalanine catabolic process (GO:0006559)3.69802781
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.69802781
21endothelial cell chemotaxis (GO:0035767)3.69612132
22negative regulation of catenin import into nucleus (GO:0035414)3.65788889
23amyloid precursor protein catabolic process (GO:0042987)3.65742842
24regulation of protein activation cascade (GO:2000257)3.64018068
25epoxygenase P450 pathway (GO:0019373)3.58275451
26atrioventricular valve morphogenesis (GO:0003181)3.58133011
27regulation of complement activation (GO:0030449)3.55127895
28lymphangiogenesis (GO:0001946)3.54843857
29mesodermal cell differentiation (GO:0048333)3.53714974
30regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.51851424
31L-phenylalanine metabolic process (GO:0006558)3.51554598
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.51554598
33aromatic amino acid family catabolic process (GO:0009074)3.48622732
34cell adhesion mediated by integrin (GO:0033627)3.46172015
35calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.42453986
36cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.40605494
37actin filament depolymerization (GO:0030042)3.39441029
38sulfur amino acid catabolic process (GO:0000098)3.36633904
39regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.36247142
40fibrinolysis (GO:0042730)3.34794317
41indole-containing compound catabolic process (GO:0042436)3.31994537
42indolalkylamine catabolic process (GO:0046218)3.31994537
43tryptophan catabolic process (GO:0006569)3.31994537
44regulation of transforming growth factor beta1 production (GO:0032908)3.29289890
45cysteine metabolic process (GO:0006534)3.29006517
46endothelium development (GO:0003158)3.28460539
47sexual reproduction (GO:0019953)3.26138589
48cellular response to gonadotropin stimulus (GO:0071371)3.20646855
49bundle of His cell to Purkinje myocyte communication (GO:0086069)3.19451007
50high-density lipoprotein particle remodeling (GO:0034375)3.17879820
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.16477835
52vascular endothelial growth factor signaling pathway (GO:0038084)3.13899488
53glomerular visceral epithelial cell development (GO:0072015)3.13507065
54regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.12380177
55kynurenine metabolic process (GO:0070189)3.12340767
56endocrine hormone secretion (GO:0060986)3.12276345
57regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.10606922
58tryptophan metabolic process (GO:0006568)3.07830072
59androgen biosynthetic process (GO:0006702)3.07670975
60desmosome organization (GO:0002934)3.04835855
61homocysteine metabolic process (GO:0050667)3.04351028
62cellular response to hepatocyte growth factor stimulus (GO:0035729)3.04254446
63response to hepatocyte growth factor (GO:0035728)3.04254446
64retina vasculature morphogenesis in camera-type eye (GO:0061299)3.03942166
65alpha-linolenic acid metabolic process (GO:0036109)3.02064168
66urea metabolic process (GO:0019627)3.01581098
67urea cycle (GO:0000050)3.01581098
68regulation of apoptotic process involved in morphogenesis (GO:1902337)2.99570957
69cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.98910773
70regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.98030411
71lung vasculature development (GO:0060426)2.95953894
72vitamin A metabolic process (GO:0006776)2.95575113
73bile acid biosynthetic process (GO:0006699)2.93061388
74regulation of endothelial cell differentiation (GO:0045601)2.92653402
75cellular response to reactive nitrogen species (GO:1902170)2.89421652
76glomerular epithelial cell development (GO:0072310)2.89286425
77growth hormone secretion (GO:0030252)2.88974563
78reverse cholesterol transport (GO:0043691)2.85867475
79endothelial cell proliferation (GO:0001935)2.83777426
80positive regulation of endothelial cell differentiation (GO:0045603)2.83562573
81lymph vessel development (GO:0001945)2.82224947
82cytoskeletal anchoring at plasma membrane (GO:0007016)2.81954927
83negative regulation of blood coagulation (GO:0030195)2.80685301
84negative regulation of hemostasis (GO:1900047)2.80685301
85ethanol oxidation (GO:0006069)2.79651543
86dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.79246242
87epithelial cell-cell adhesion (GO:0090136)2.78676169
88regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.77702287
89regulation of triglyceride catabolic process (GO:0010896)2.75119810
90metanephric nephron epithelium development (GO:0072243)2.75036148
91response to follicle-stimulating hormone (GO:0032354)2.74501500
92omega-hydroxylase P450 pathway (GO:0097267)2.74136179
93peptide catabolic process (GO:0043171)2.73253926
94positive regulation of receptor recycling (GO:0001921)2.72516064
95semaphorin-plexin signaling pathway (GO:0071526)2.72475546
96complement activation, classical pathway (GO:0006958)2.72154211
97lung lobe morphogenesis (GO:0060463)2.71907399
98bile acid and bile salt transport (GO:0015721)2.71769161
99plasma lipoprotein particle clearance (GO:0034381)2.71034396
100drug catabolic process (GO:0042737)2.70978249
101regulation of plasminogen activation (GO:0010755)2.70645382
102glomerular basement membrane development (GO:0032836)2.70498280
103embryonic process involved in female pregnancy (GO:0060136)2.69867850
104regulation of cholesterol homeostasis (GO:2000188)2.69861669
105nitrogen cycle metabolic process (GO:0071941)2.69304316
106cell migration involved in sprouting angiogenesis (GO:0002042)2.68986439
107cellular response to nitric oxide (GO:0071732)2.68758168
108positive regulation of blood coagulation (GO:0030194)2.68407169
109positive regulation of hemostasis (GO:1900048)2.68407169
110vasculature development (GO:0001944)2.68088066
111regulation of bile acid biosynthetic process (GO:0070857)2.67782303
112outflow tract septum morphogenesis (GO:0003148)2.67182780
113renal filtration (GO:0097205)2.66703598
114positive regulation of protein kinase C signaling (GO:0090037)2.65933431
115fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.65547128
116negative regulation of coagulation (GO:0050819)2.65156019
117phospholipid efflux (GO:0033700)2.63802133
118negative regulation of lipase activity (GO:0060192)2.63569649
119basement membrane organization (GO:0071711)2.63080210
120peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.62991145
121triglyceride homeostasis (GO:0070328)2.62814510
122acylglycerol homeostasis (GO:0055090)2.62814510
123positive regulation of digestive system process (GO:0060456)2.60759827
124regulation of integrin-mediated signaling pathway (GO:2001044)2.60396916
125response to nitrosative stress (GO:0051409)2.59806163
126amino-acid betaine metabolic process (GO:0006577)2.58583629
127cellular glucuronidation (GO:0052695)2.58267153
128negative regulation of wound healing (GO:0061045)2.57563943
129regulation of p38MAPK cascade (GO:1900744)2.56935204
130protein-lipid complex remodeling (GO:0034368)2.56810784
131macromolecular complex remodeling (GO:0034367)2.56810784
132plasma lipoprotein particle remodeling (GO:0034369)2.56810784
133hormone catabolic process (GO:0042447)2.56628237
134response to gonadotropin (GO:0034698)2.55576746
135cholesterol efflux (GO:0033344)2.55497197
136glyoxylate metabolic process (GO:0046487)2.55355634
137bile acid metabolic process (GO:0008206)2.55096558
138regulation of tight junction assembly (GO:2000810)2.54696127
139cell volume homeostasis (GO:0006884)2.54511349
140pattern specification involved in kidney development (GO:0061004)2.54171159
141planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54047811
142positive regulation of coagulation (GO:0050820)2.52422233
143metanephric epithelium development (GO:0072207)2.52092193
144low-density lipoprotein particle clearance (GO:0034383)2.50697136
145cholesterol homeostasis (GO:0042632)2.50116153
146sterol homeostasis (GO:0055092)2.49471360
147extracellular fibril organization (GO:0043206)2.47959609
148cell-substrate junction assembly (GO:0007044)2.47209284
149adherens junction assembly (GO:0034333)2.47187831
150blood vessel endothelial cell migration (GO:0043534)2.46445252
151transcytosis (GO:0045056)2.46086847
152metanephric nephron tubule development (GO:0072234)2.45842101
153metanephric tubule development (GO:0072170)2.45842101
154regulation of cholesterol esterification (GO:0010872)2.45705873
155endothelial cell morphogenesis (GO:0001886)2.45696257
156negative regulation of activin receptor signaling pathway (GO:0032926)2.44930948
157positive regulation of p38MAPK cascade (GO:1900745)2.44905454
158branching involved in salivary gland morphogenesis (GO:0060445)2.44062754
159imidazole-containing compound metabolic process (GO:0052803)2.43920174
160negative regulation of cholesterol transport (GO:0032375)2.43298998
161negative regulation of sterol transport (GO:0032372)2.43298998
162cellular response to BMP stimulus (GO:0071773)2.43251757
163response to BMP (GO:0071772)2.43251757
164midgut development (GO:0007494)2.43250669
165extracellular matrix assembly (GO:0085029)2.43129925
166exogenous drug catabolic process (GO:0042738)2.42935128
167smooth muscle tissue development (GO:0048745)2.40198334
168interleukin-6-mediated signaling pathway (GO:0070102)2.40133045
169amyloid precursor protein metabolic process (GO:0042982)2.39670670
170cellular response to epinephrine stimulus (GO:0071872)2.38908743
171multicellular organismal water homeostasis (GO:0050891)2.38198514
172regulation of water loss via skin (GO:0033561)2.36958663
173regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.35650253
174positive regulation of metanephros development (GO:0072216)2.35600599
175vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.34251845
176cellular response to antibiotic (GO:0071236)2.30921044
177positive regulation of nitric-oxide synthase activity (GO:0051000)2.30643024
178angiogenesis involved in wound healing (GO:0060055)2.30501527
179complement activation (GO:0006956)2.30071926
180negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.29057512
181fibril organization (GO:0097435)2.25563675
182regulation of axon extension involved in axon guidance (GO:0048841)2.25087337
183establishment of skin barrier (GO:0061436)2.24601701
184regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.24221701
185sequestering of extracellular ligand from receptor (GO:0035581)2.23417511
186positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.23381850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.14025039
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.13202792
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.89268180
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.43349849
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.41148016
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.31385687
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.23281772
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.99844518
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.98497146
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.65060545
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60089816
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54172883
13* ESR1_21235772_ChIP-Seq_MCF-7_Human2.27938734
14CLOCK_20551151_ChIP-Seq_293T_Human2.21269387
15* ESR2_21235772_ChIP-Seq_MCF-7_Human2.17631071
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97144837
17PPAR_26484153_Chip-Seq_NCI-H1993_Human1.88023878
18GATA2_21666600_ChIP-Seq_HMVEC_Human1.86761736
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85809652
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.80584442
21CDX2_20551321_ChIP-Seq_CACO-2_Human1.79193523
22GATA1_22025678_ChIP-Seq_K562_Human1.76587683
23* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76210712
24SOX2_20726797_ChIP-Seq_SW620_Human1.73923088
25CJUN_26792858_Chip-Seq_BT549_Human1.70730111
26* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65223974
27* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60733687
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.58460435
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57792163
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56864271
31* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56807352
32* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55566298
33NFIB_24661679_ChIP-Seq_LUNG_Mouse1.55212635
34* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50363577
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48717894
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48331648
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48026893
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47895049
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47895049
40* GATA4_25053715_ChIP-Seq_YYC3_Human1.45964790
41* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.45522200
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44221528
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.44063268
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41917490
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41917490
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41917490
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41871778
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41175420
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.35653259
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35172337
51* FOXA2_19822575_ChIP-Seq_HepG2_Human1.33877373
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33817303
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33817303
54* AHR_22903824_ChIP-Seq_MCF-7_Human1.33699118
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31984037
56* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30955661
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24148938
58TP53_18474530_ChIP-ChIP_U2OS_Human1.23859214
59LXR_22292898_ChIP-Seq_THP-1_Human1.23619051
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22640996
61* SMAD4_21741376_ChIP-Seq_HESCs_Human1.22151619
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20409807
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19298671
64KDM2B_26808549_Chip-Seq_K562_Human1.18880500
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16276706
66* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15989741
67* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14784859
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14085824
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13192324
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12932430
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10981933
72TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09354116
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.08779201
74* ARNT_22903824_ChIP-Seq_MCF-7_Human1.08471702
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07299491
76* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06417684
77TCF4_18268006_ChIP-ChIP_LS174T_Human1.06225942
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05345293
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05138534
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.04645217
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.04633343
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04419460
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03061448
84* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01560003
85TP63_23658742_ChIP-Seq_EP156T_Human1.01448970
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00647638
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00647638
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00054992
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99400972
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97810702
91GATA1_19941826_ChIP-Seq_K562_Human0.97115974
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96978729
93P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96401570
94* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96366162
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96156832
96STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95932102
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94960639
98TBX20_22328084_ChIP-Seq_HEART_Mouse0.94578886
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.94578886
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93093524
101JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92368950
102GATA6_25053715_ChIP-Seq_YYC3_Human0.91426217
103BCAT_22108803_ChIP-Seq_LS180_Human0.91391427
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90862048
105TP53_16413492_ChIP-PET_HCT116_Human0.90787433
106FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90491057
107RACK7_27058665_Chip-Seq_MCF-7_Human0.90178305
108HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89968687
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89841785
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89818822
111BRD4_25478319_ChIP-Seq_HGPS_Human0.88281153
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87134015
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86529614
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85868876
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84884781
116* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84817162
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84076295
118DROSHA_22980978_ChIP-Seq_HELA_Human0.83781245
119KLF5_25053715_ChIP-Seq_YYC3_Human0.83701602
120* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83414620
121WT1_19549856_ChIP-ChIP_CCG9911_Human0.82393969
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.82380307
123* GATA3_24758297_ChIP-Seq_MCF-7_Human0.82143401
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81150108
125RUNX1_27514584_Chip-Seq_MCF-7_Human0.81041235
126BP1_19119308_ChIP-ChIP_Hs578T_Human0.80722232
127HNF4A_19822575_ChIP-Seq_HepG2_Human0.78750229
128RXR_22108803_ChIP-Seq_LS180_Human0.78002402
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77752218
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77449850
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76841412
132* EED_16625203_ChIP-ChIP_MESCs_Mouse0.74524142
133UBF1/2_26484160_Chip-Seq_HMECs_Human0.73314311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.33228429
2MP0002139_abnormal_hepatobiliary_system4.28131110
3MP0005085_abnormal_gallbladder_physiolo3.45012101
4MP0010368_abnormal_lymphatic_system3.33214931
5MP0008875_abnormal_xenobiotic_pharmacok3.18106526
6MP0002138_abnormal_hepatobiliary_system3.12875627
7MP0005365_abnormal_bile_salt3.01602821
8MP0005409_darkened_coat_color3.00104861
9MP0003252_abnormal_bile_duct2.90505673
10MP0004272_abnormal_basement_membrane2.75267094
11MP0002254_reproductive_system_inflammat2.57494944
12MP0004782_abnormal_surfactant_physiolog2.42138756
13MP0003705_abnormal_hypodermis_morpholog2.27357946
14MP0008004_abnormal_stomach_pH2.15553996
15MP0001879_abnormal_lymphatic_vessel2.12999166
16MP0001958_emphysema1.97906524
17MP0010329_abnormal_lipoprotein_level1.96766511
18MP0002796_impaired_skin_barrier1.88582463
19MP0003191_abnormal_cellular_cholesterol1.86075540
20MP0001666_abnormal_nutrient_absorption1.85059890
21MP0003724_increased_susceptibility_to1.83601936
22MP0003566_abnormal_cell_adhesion1.80407092
23MP0003011_delayed_dark_adaptation1.75863913
24MP0005083_abnormal_biliary_tract1.75549452
25MP0005503_abnormal_tendon_morphology1.72314529
26MP0005275_abnormal_skin_tensile1.71787831
27MP0010234_abnormal_vibrissa_follicle1.69830522
28MP0004019_abnormal_vitamin_homeostasis1.66221838
29MP0009384_cardiac_valve_regurgitation1.64281130
30MP0002060_abnormal_skin_morphology1.58632679
31MP0000566_synostosis1.56109024
32MP0000383_abnormal_hair_follicle1.54298644
33MP0010030_abnormal_orbit_morphology1.49729707
34MP0003453_abnormal_keratinocyte_physiol1.48703944
35MP0010678_abnormal_skin_adnexa1.48325715
36MP0004084_abnormal_cardiac_muscle1.47890662
37MP0003890_abnormal_embryonic-extraembry1.46801509
38MP0005332_abnormal_amino_acid1.45573584
39MP0000537_abnormal_urethra_morphology1.38551644
40MP0008438_abnormal_cutaneous_collagen1.37764430
41MP0005508_abnormal_skeleton_morphology1.36177502
42MP0009840_abnormal_foam_cell1.35923175
43MP0005167_abnormal_blood-brain_barrier1.34484531
44MP0002098_abnormal_vibrissa_morphology1.34104487
45MP0002933_joint_inflammation1.34025374
46MP0009053_abnormal_anal_canal1.32816450
47MP0005023_abnormal_wound_healing1.31524866
48MP0002127_abnormal_cardiovascular_syste1.31450404
49MP0003136_yellow_coat_color1.30805950
50MP0003941_abnormal_skin_development1.30212200
51MP0002877_abnormal_melanocyte_morpholog1.27885888
52MP0000465_gastrointestinal_hemorrhage1.27442499
53MP0003195_calcinosis1.26576882
54MP0009643_abnormal_urine_homeostasis1.26508627
55MP0004233_abnormal_muscle_weight1.23956752
56MP0010352_gastrointestinal_tract_polyps1.23318025
57MP0001346_abnormal_lacrimal_gland1.21585021
58MP0002118_abnormal_lipid_homeostasis1.20394622
59MP0001188_hyperpigmentation1.19155730
60MP0000579_abnormal_nail_morphology1.18285852
61MP0008775_abnormal_heart_ventricle1.18122764
62MP0003300_gastrointestinal_ulcer1.17289365
63MP0005084_abnormal_gallbladder_morpholo1.16767826
64MP0003868_abnormal_feces_composition1.14469583
65MP0002295_abnormal_pulmonary_circulatio1.14459642
66MP0005330_cardiomyopathy1.14028295
67MP0003283_abnormal_digestive_organ1.13207133
68MP0000609_abnormal_liver_physiology1.12959930
69MP0002998_abnormal_bone_remodeling1.11550092
70MP0005501_abnormal_skin_physiology1.11421040
71MP0000767_abnormal_smooth_muscle1.11299937
72MP0009764_decreased_sensitivity_to1.10801609
73MP0003806_abnormal_nucleotide_metabolis1.10271327
74MP0005623_abnormal_meninges_morphology1.09052308
75MP0003091_abnormal_cell_migration1.09051367
76MP0002925_abnormal_cardiovascular_devel1.04269093
77MP0005164_abnormal_response_to1.02759979
78MP0001614_abnormal_blood_vessel1.01083631
79MP0001851_eye_inflammation1.00376794
80MP0001216_abnormal_epidermal_layer0.98966859
81MP0000467_abnormal_esophagus_morphology0.98622399
82MP0001881_abnormal_mammary_gland0.97684889
83MP0004215_abnormal_myocardial_fiber0.96952852
84MP0002932_abnormal_joint_morphology0.96432398
85MP0005319_abnormal_enzyme/_coenzyme0.94119257
86MP0002136_abnormal_kidney_physiology0.93097724
87MP0000462_abnormal_digestive_system0.92160188
88MP0000751_myopathy0.92104224
89MP0005076_abnormal_cell_differentiation0.91895240
90MP0004036_abnormal_muscle_relaxation0.90743473
91MP0000516_abnormal_urinary_system0.89858972
92MP0005367_renal/urinary_system_phenotyp0.89858972
93MP0003385_abnormal_body_wall0.89163533
94MP0001756_abnormal_urination0.88077595
95MP0005666_abnormal_adipose_tissue0.87172784
96MP0000647_abnormal_sebaceous_gland0.86758254
97MP0000249_abnormal_blood_vessel0.86113981
98MP0002168_other_aberrant_phenotype0.85925147
99MP0005408_hypopigmentation0.85708968
100MP0001664_abnormal_digestion0.84250822
101MP0006138_congestive_heart_failure0.83598389
102MP0000013_abnormal_adipose_tissue0.83226203
103MP0005166_decreased_susceptibility_to0.82409223
104MP0003279_aneurysm0.82181645
105MP0005390_skeleton_phenotype0.82141915
106MP0004264_abnormal_extraembryonic_tissu0.81163922
107MP0002132_abnormal_respiratory_system0.80508234
108MP0005165_increased_susceptibility_to0.80121779
109MP0010630_abnormal_cardiac_muscle0.79971596
110MP0005595_abnormal_vascular_smooth0.79114528
111MP0005647_abnormal_sex_gland0.78718723
112MP0001873_stomach_inflammation0.77627994
113MP0003045_fibrosis0.77360584
114MP0000627_abnormal_mammary_gland0.77169051
115MP0006054_spinal_hemorrhage0.77045991
116MP0004510_myositis0.77012119
117MP0004858_abnormal_nervous_system0.76893316
118MP0005670_abnormal_white_adipose0.76654876
119MP0002133_abnormal_respiratory_system0.76475105
120MP0005388_respiratory_system_phenotype0.76475105
121MP0010771_integument_phenotype0.76056810
122MP0000762_abnormal_tongue_morphology0.75577782
123MP0000538_abnormal_urinary_bladder0.75479745
124MP0005375_adipose_tissue_phenotype0.75413911
125MP0000377_abnormal_hair_follicle0.73990038
126MP0005248_abnormal_Harderian_gland0.73475236
127MP0000534_abnormal_ureter_morphology0.70952507
128MP0002972_abnormal_cardiac_muscle0.70446410
129MP0003638_abnormal_response/metabolism_0.69983251
130MP0001849_ear_inflammation0.69272310
131MP0004883_abnormal_blood_vessel0.68707248
132MP0000681_abnormal_thyroid_gland0.68321246
133MP0002928_abnormal_bile_duct0.67789622
134MP0002135_abnormal_kidney_morphology0.67600127
135MP0001177_atelectasis0.67575570
136MP0002876_abnormal_thyroid_physiology0.67394114
137MP0002896_abnormal_bone_mineralization0.67191000
138MP0005220_abnormal_exocrine_pancreas0.67018650
139MP0000427_abnormal_hair_cycle0.66859560
140MP0010155_abnormal_intestine_physiology0.66163982
141MP0009780_abnormal_chondrocyte_physiolo0.65926028
142MP0004085_abnormal_heartbeat0.65326091
143MP0002128_abnormal_blood_circulation0.65262014
144MP0003828_pulmonary_edema0.65121914
145MP0005385_cardiovascular_system_phenoty0.64839913
146MP0001544_abnormal_cardiovascular_syste0.64839913
147MP0001175_abnormal_lung_morphology0.63276682

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.42534836
2Intrahepatic cholestasis (HP:0001406)4.21754800
3Onycholysis (HP:0001806)4.12825782
4Interstitial pulmonary disease (HP:0006530)4.09094345
5Esophageal varix (HP:0002040)3.99502232
6Complement deficiency (HP:0004431)3.97319226
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.95653886
8Right ventricular cardiomyopathy (HP:0011663)3.86421816
9Xanthomatosis (HP:0000991)3.78020393
10Prolonged partial thromboplastin time (HP:0003645)3.67057380
11Atrophic scars (HP:0001075)3.55678219
12Focal segmental glomerulosclerosis (HP:0000097)3.45785002
13Vascular calcification (HP:0004934)3.44389378
14Polycythemia (HP:0001901)3.42043950
15Joint hemorrhage (HP:0005261)3.36682484
16Hyperactive renin-angiotensin system (HP:0000841)3.36385795
17Milia (HP:0001056)3.34738490
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.26494626
19Cardiovascular calcification (HP:0011915)3.25947904
20Facial shape deformation (HP:0011334)3.08239219
21Potter facies (HP:0002009)3.08239219
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.05841140
23Abnormality of complement system (HP:0005339)3.04451347
24Protrusio acetabuli (HP:0003179)3.01070459
25Glomerulosclerosis (HP:0000096)2.99687441
26Cerebral aneurysm (HP:0004944)2.95875277
27Abnormality of the common coagulation pathway (HP:0010990)2.95726064
28Nephritis (HP:0000123)2.93314897
29Fragile nails (HP:0001808)2.92178611
30Ureteral duplication (HP:0000073)2.86903593
31Arterial tortuosity (HP:0005116)2.82618579
32Vascular tortuosity (HP:0004948)2.79658481
33Hyperlipoproteinemia (HP:0010980)2.78457368
34Anomalous pulmonary venous return (HP:0010772)2.78420365
35Hematochezia (HP:0002573)2.72834906
36Plantar hyperkeratosis (HP:0007556)2.72250385
37Abnormality of the pulmonary veins (HP:0011718)2.70862109
38Abnormal pancreas size (HP:0012094)2.68263678
39Myocardial infarction (HP:0001658)2.67653817
40Hypoalphalipoproteinemia (HP:0003233)2.66665091
41Pulmonary artery stenosis (HP:0004415)2.64608984
42Epidermoid cyst (HP:0200040)2.64458427
43Aortic aneurysm (HP:0004942)2.63469487
44Abnormal umbilical cord blood vessels (HP:0011403)2.63422005
45Single umbilical artery (HP:0001195)2.63422005
46Abnormality of the fetal cardiovascular system (HP:0010948)2.63422005
47Neonatal death (HP:0003811)2.61122003
48Abnormality of the intrinsic pathway (HP:0010989)2.61109202
49Bronchomalacia (HP:0002780)2.60141392
50Large earlobe (HP:0009748)2.59583288
51Hypobetalipoproteinemia (HP:0003563)2.58028377
52Alopecia of scalp (HP:0002293)2.54800152
53Spontaneous hematomas (HP:0007420)2.52083209
54Rhizomelia (HP:0008905)2.51623485
55Aortic regurgitation (HP:0001659)2.48621729
56Double outlet right ventricle (HP:0001719)2.47913748
57Congenital malformation of the right heart (HP:0011723)2.47913748
58Respiratory distress (HP:0002098)2.45763454
59Hypolipoproteinemia (HP:0010981)2.45685062
60Vertebral arch anomaly (HP:0008438)2.45501889
61Patent foramen ovale (HP:0001655)2.42842284
62Fat malabsorption (HP:0002630)2.40610087
63Cervical subluxation (HP:0003308)2.37005485
64Osteolytic defects of the hand bones (HP:0009699)2.36929253
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.36929253
66Pulmonary hypertension (HP:0002092)2.32329136
67Scotoma (HP:0000575)2.30593691
68Tubulointerstitial fibrosis (HP:0005576)2.29737982
69Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.29052327
70Small epiphyses (HP:0010585)2.24948007
71Hydroxyprolinuria (HP:0003080)2.20810278
72Abnormality of proline metabolism (HP:0010907)2.20810278
73Broad face (HP:0000283)2.19737115
74Aortic dissection (HP:0002647)2.19149054
75Conjugated hyperbilirubinemia (HP:0002908)2.18006681
76Ulnar bowing (HP:0003031)2.17168378
77Premature rupture of membranes (HP:0001788)2.16294898
78Wormian bones (HP:0002645)2.15286893
79Menorrhagia (HP:0000132)2.14907991
80Hemorrhage of the eye (HP:0011885)2.13914706
81Increased mean platelet volume (HP:0011877)2.13517371
82Aortic valve stenosis (HP:0001650)2.13108544
83Broad metatarsal (HP:0001783)2.12557302
84Abnormality of carpal bone ossification (HP:0006257)2.12274295
85Malnutrition (HP:0004395)2.11682130
86Abnormal hemoglobin (HP:0011902)2.10132912
87Limited hip movement (HP:0008800)2.09601675
88Short clavicles (HP:0000894)2.09249638
89Abnormality of sulfur amino acid metabolism (HP:0004339)2.06491266
90Amyloidosis (HP:0011034)2.05950069
91Vertebral clefting (HP:0008428)2.05425731
92Glomerulonephritis (HP:0000099)2.04659805
93Choroideremia (HP:0001139)2.03549517
94Abnormality of purine metabolism (HP:0004352)2.03405501
95Hypoglycemic coma (HP:0001325)2.03234418
96Visceral angiomatosis (HP:0100761)2.02553293
97Relative macrocephaly (HP:0004482)2.01119458
98Gout (HP:0001997)2.00864333
99Short nail (HP:0001799)2.00391664
100Persistence of primary teeth (HP:0006335)1.99517799
101Flat acetabular roof (HP:0003180)1.99376879
102Hypercholesterolemia (HP:0003124)1.98888258
103Shallow orbits (HP:0000586)1.98352665
104Renal salt wasting (HP:0000127)1.98205081
105Syncope (HP:0001279)1.98151899
106Abnormal ossification of hand bones (HP:0005921)1.97569503
107Thick nail (HP:0001805)1.96354042
108Hyperammonemia (HP:0001987)1.95749606
109Abnormality of the aortic arch (HP:0012303)1.95234738
110Hyperglycinuria (HP:0003108)1.95220879
111Hyperkalemia (HP:0002153)1.95220208
112Abnormality of chloride homeostasis (HP:0011422)1.94858002
113Portal hypertension (HP:0001409)1.93782400
114Ectopia lentis (HP:0001083)1.93104333
115Systemic lupus erythematosus (HP:0002725)1.93092753
116Lymphangioma (HP:0100764)1.92869623
117Aneurysm (HP:0002617)1.92165842
118Aplasia cutis congenita (HP:0001057)1.91459164
119Aplasia/Hypoplasia of the clavicles (HP:0006710)1.91045937
120Acanthosis nigricans (HP:0000956)1.89976771
121Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89755367
122Nail dystrophy (HP:0008404)1.87624424
123Abnormality of nucleobase metabolism (HP:0010932)1.86532212
124Coronal craniosynostosis (HP:0004440)1.86344396
125Hepatocellular carcinoma (HP:0001402)1.86189336
126Ventricular tachycardia (HP:0004756)1.85526202
127Hyperaldosteronism (HP:0000859)1.85463150
128Abnormality of the umbilical cord (HP:0010881)1.84958970
129Abnormal vertebral ossification (HP:0100569)1.84436805
130Hypoplasia of dental enamel (HP:0006297)1.84308917
131Rectal prolapse (HP:0002035)1.84077178
132Hemangiomatosis (HP:0007461)1.83852954
133Stenosis of the external auditory canal (HP:0000402)1.83331429
134Mitral valve prolapse (HP:0001634)1.82747096
135Oligodontia (HP:0000677)1.82672173
136Abnormality of the right ventricle (HP:0001707)1.82586335
137Recurrent gram-negative bacterial infections (HP:0005420)1.81377663
138Mitral stenosis (HP:0001718)1.81308770
139Abnormal hand bone ossification (HP:0010660)1.80591468
140Hypoplastic nipples (HP:0002557)1.80267983
141Abnormal platelet volume (HP:0011876)1.80036470
142Decreased circulating renin level (HP:0003351)1.79317691
143Stroke (HP:0001297)1.79309237
144Ileus (HP:0002595)1.78729793
145Abnormality of the dental root (HP:0006486)1.78021429
146Taurodontia (HP:0000679)1.78021429
147Abnormality of permanent molar morphology (HP:0011071)1.78021429
148Fragile skin (HP:0001030)1.77525187
149Distal lower limb muscle weakness (HP:0009053)1.77129353
150Joint laxity (HP:0001388)1.76845933
151Tachypnea (HP:0002789)1.75974995
152Abnormality of serine family amino acid metabolism (HP:0010894)1.75601473
153Abnormality of glycine metabolism (HP:0010895)1.75601473
154Abnormality of molar (HP:0011077)1.75106398
155Abnormality of molar morphology (HP:0011070)1.75106398
156Abnormality of the dental pulp (HP:0006479)1.75028187
157Mesangial abnormality (HP:0001966)1.74962481
158Blue sclerae (HP:0000592)1.74920470
159Wrist flexion contracture (HP:0001239)1.74795503
160Spinal rigidity (HP:0003306)1.74716465
161Hematuria (HP:0000790)1.73030375
162Long toe (HP:0010511)1.72930881
163Overgrowth (HP:0001548)1.71830061
164Short humerus (HP:0005792)1.71760880
165Striae distensae (HP:0001065)1.71086867
166Steatorrhea (HP:0002570)1.70463075
167Hyperglycinemia (HP:0002154)1.70197533
168Camptodactyly of toe (HP:0001836)1.69830050
169Abnormality of the hepatic vasculature (HP:0006707)1.69634472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.11317849
2EPHA23.76345782
3LMTK23.28893987
4TGFBR23.07073011
5LATS13.06513304
6EPHB22.79336459
7ERN12.76260059
8PRPF4B2.60294942
9FGFR42.49941798
10KDR2.41831885
11MST1R2.35904306
12FER2.25192892
13FRK2.24910414
14EPHB12.19455840
15MAP3K32.15914257
16SIK12.12074545
17MST42.01142743
18MYLK1.98932713
19TTN1.89247531
20PTK61.85394610
21EPHA31.77949417
22PTK21.77070909
23INSRR1.74384910
24RIPK11.70946065
25STK101.65300457
26MAP3K61.52956862
27FGFR21.48703186
28NME11.47215861
29LRRK21.47205018
30PDK21.44273378
31WNK41.43119033
32ERBB41.39860392
33STK38L1.36308442
34TRIB31.34434836
35MAPK151.31204182
36MET1.30577146
37STK381.21210041
38MAP3K141.19024507
39MAP3K21.16564849
40PDGFRA1.16059838
41GRK11.10510295
42IRAK31.09628619
43FGFR31.09598635
44ACVR1B1.09330515
45DDR21.08212272
46PIK3CG1.07561258
47NUAK11.04855440
48PAK41.04540332
49PRKD21.02826405
50TGFBR11.01166975
51PIK3CA1.01065318
52PAK20.98319694
53STK30.97501319
54RPS6KA20.97185210
55MAP2K20.92277997
56ILK0.91933926
57NEK90.91505105
58MAPK70.90948873
59MARK20.90218991
60CSK0.90180054
61BCKDK0.89274372
62TAOK30.89198747
63CAMK1D0.89078101
64DMPK0.88891895
65TESK10.84296079
66MAP3K120.83656015
67ICK0.82348303
68GSK3A0.82293303
69NTRK10.82050133
70ERBB20.81875944
71TRPM70.79341652
72JAK10.79094049
73AKT30.78442013
74MATK0.77010754
75BMX0.76270905
76MAP3K70.73815069
77TAOK20.72769160
78MAP2K30.69776531
79TYK20.67716633
80STK390.67531142
81MAP2K10.67433095
82PDGFRB0.65140346
83RPS6KL10.64847432
84RPS6KC10.64847432
85CDK60.62677630
86MELK0.61745869
87NLK0.61643823
88ROCK20.61476061
89PRKG20.60344429
90PRKD10.60063220
91MAPKAPK30.59040628
92ZAK0.58385231
93CHUK0.58153467
94LATS20.57693753
95PAK30.57655891
96PRKAA20.57553870
97PDPK10.56551927
98ROCK10.55035310
99HIPK20.53092073
100MAPK120.52562835
101EGFR0.50978692
102BMPR1B0.50855599
103MAP3K10.50830453
104DYRK1B0.49559328
105CDK90.49123479
106RPS6KA60.48933839
107FGFR10.48892268
108CAMK1G0.48764154
109TBK10.47710078
110ZAP700.47640009
111PKN20.47617005
112SGK30.45008983
113ABL20.44966208
114IGF1R0.44938569
115PTK2B0.44020214
116RPS6KA40.43780377
117MAPK30.43478421
118SGK20.40843977
119PRKCE0.40521228
120STK240.39786575
121NEK60.39654954
122IRAK10.38447417
123JAK20.38314467
124ABL10.37534846
125MTOR0.37336243
126PRKD30.37193146
127RET0.35605905
128CAMK2G0.35203741
129INSR0.34942986
130IKBKE0.34765181
131MAPK10.34473257
132CAMK40.34454223
133SRC0.34078706
134SGK4940.32036632
135SGK2230.32036632
136TNIK0.31575824
137MAPKAPK20.30619330
138RPS6KB20.29505767
139CDC42BPA0.27698365

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.31970986
2Complement and coagulation cascades_Homo sapiens_hsa046102.93181356
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.82381273
4Tryptophan metabolism_Homo sapiens_hsa003802.57254931
5Caffeine metabolism_Homo sapiens_hsa002322.51097253
6Nitrogen metabolism_Homo sapiens_hsa009102.44774212
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.34843552
8Histidine metabolism_Homo sapiens_hsa003402.21113130
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.19205914
10Arginine biosynthesis_Homo sapiens_hsa002202.17934692
11Fatty acid degradation_Homo sapiens_hsa000712.08677894
12Chemical carcinogenesis_Homo sapiens_hsa052042.08506777
13ECM-receptor interaction_Homo sapiens_hsa045122.00871289
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98596695
15PPAR signaling pathway_Homo sapiens_hsa033201.88271642
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.85809447
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83569365
18Retinol metabolism_Homo sapiens_hsa008301.77944879
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75964173
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74934376
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67485398
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61377567
23Staphylococcus aureus infection_Homo sapiens_hsa051501.60726716
24Sulfur metabolism_Homo sapiens_hsa009201.59425888
25Bile secretion_Homo sapiens_hsa049761.54065237
26Peroxisome_Homo sapiens_hsa041461.52670029
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48417917
28Pancreatic secretion_Homo sapiens_hsa049721.47245607
29Phenylalanine metabolism_Homo sapiens_hsa003601.45081644
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.44653133
31Vitamin digestion and absorption_Homo sapiens_hsa049771.43049262
32beta-Alanine metabolism_Homo sapiens_hsa004101.42760881
33Fatty acid metabolism_Homo sapiens_hsa012121.39018146
34Dilated cardiomyopathy_Homo sapiens_hsa054141.37685500
35ABC transporters_Homo sapiens_hsa020101.32760830
36Tyrosine metabolism_Homo sapiens_hsa003501.32053372
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30734592
38Selenocompound metabolism_Homo sapiens_hsa004501.25907333
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23032703
40Thyroid hormone synthesis_Homo sapiens_hsa049181.19304042
41Adherens junction_Homo sapiens_hsa045201.17403094
42Focal adhesion_Homo sapiens_hsa045101.17374763
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17174758
44Fat digestion and absorption_Homo sapiens_hsa049751.15248576
45Small cell lung cancer_Homo sapiens_hsa052221.11223374
46Starch and sucrose metabolism_Homo sapiens_hsa005001.09042850
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07822588
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.05919641
49Amoebiasis_Homo sapiens_hsa051461.05806510
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.03870337
51Notch signaling pathway_Homo sapiens_hsa043300.99997677
52Mineral absorption_Homo sapiens_hsa049780.98769358
53Butanoate metabolism_Homo sapiens_hsa006500.98643711
54Propanoate metabolism_Homo sapiens_hsa006400.97982023
55Choline metabolism in cancer_Homo sapiens_hsa052310.97416071
56Fatty acid biosynthesis_Homo sapiens_hsa000610.92183478
57Fatty acid elongation_Homo sapiens_hsa000620.90675297
58Renin secretion_Homo sapiens_hsa049240.89886854
59Other glycan degradation_Homo sapiens_hsa005110.89773372
60Gastric acid secretion_Homo sapiens_hsa049710.85604371
61Circadian rhythm_Homo sapiens_hsa047100.85525380
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82295050
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81656031
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81560000
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.80776168
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80683844
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79425517
68Galactose metabolism_Homo sapiens_hsa000520.78485980
69Protein digestion and absorption_Homo sapiens_hsa049740.77381497
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.75999105
71TNF signaling pathway_Homo sapiens_hsa046680.74599254
72Glutathione metabolism_Homo sapiens_hsa004800.74475756
73Bladder cancer_Homo sapiens_hsa052190.74226124
74Arginine and proline metabolism_Homo sapiens_hsa003300.71998865
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.69859824
76Lysine degradation_Homo sapiens_hsa003100.69517831
77Renal cell carcinoma_Homo sapiens_hsa052110.69210592
78Thyroid cancer_Homo sapiens_hsa052160.68670598
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.68448611
80Renin-angiotensin system_Homo sapiens_hsa046140.67972687
81Proteoglycans in cancer_Homo sapiens_hsa052050.67812129
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67472849
83GnRH signaling pathway_Homo sapiens_hsa049120.65816082
84Steroid biosynthesis_Homo sapiens_hsa001000.65226294
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63388188
86Tight junction_Homo sapiens_hsa045300.61479813
87Inositol phosphate metabolism_Homo sapiens_hsa005620.60989262
88Pathways in cancer_Homo sapiens_hsa052000.57932647
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57077902
90Dorso-ventral axis formation_Homo sapiens_hsa043200.56548238
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56526734
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56000855
93Estrogen signaling pathway_Homo sapiens_hsa049150.55971886
94Folate biosynthesis_Homo sapiens_hsa007900.55971411
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54331803
96Ether lipid metabolism_Homo sapiens_hsa005650.53970965
97Melanogenesis_Homo sapiens_hsa049160.53147601
98Wnt signaling pathway_Homo sapiens_hsa043100.52900847
99Hippo signaling pathway_Homo sapiens_hsa043900.52630071
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52388231
101Pyruvate metabolism_Homo sapiens_hsa006200.50290970
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49539875
103Toxoplasmosis_Homo sapiens_hsa051450.49309477
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49272311
105Ovarian steroidogenesis_Homo sapiens_hsa049130.49183786
106Glycerolipid metabolism_Homo sapiens_hsa005610.49051151
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48713413
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48249993
109Lysosome_Homo sapiens_hsa041420.46489590
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45651276
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43700993
112Endocytosis_Homo sapiens_hsa041440.42895005
113Malaria_Homo sapiens_hsa051440.42134849
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42077633
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41789754
116Prion diseases_Homo sapiens_hsa050200.40183538
117Arachidonic acid metabolism_Homo sapiens_hsa005900.39763529
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39162722
119TGF-beta signaling pathway_Homo sapiens_hsa043500.38388476
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.38332109
121Insulin resistance_Homo sapiens_hsa049310.37595734
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36941011
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.36633877
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34840016
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33718815
126Rap1 signaling pathway_Homo sapiens_hsa040150.33439883
127Linoleic acid metabolism_Homo sapiens_hsa005910.33332164
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33161033
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30703409
130Pertussis_Homo sapiens_hsa051330.30689816
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.30509794
132Hepatitis C_Homo sapiens_hsa051600.30025703
133Basal cell carcinoma_Homo sapiens_hsa052170.27095509
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25586405
135Sphingolipid metabolism_Homo sapiens_hsa006000.25436891
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25388005
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25211133
138Platelet activation_Homo sapiens_hsa046110.25029423

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