SLCO1B7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tachykinin receptor signaling pathway (GO:0007217)9.27091372
2positive regulation of digestive system process (GO:0060456)6.89828311
3positive regulation of action potential (GO:0045760)6.27960461
4regulation of glucocorticoid secretion (GO:2000849)5.39593957
5positive regulation of steroid hormone secretion (GO:2000833)5.36225165
6histone H3-K9 demethylation (GO:0033169)5.32480186
7regulation of corticosteroid hormone secretion (GO:2000846)5.20803971
8multicellular organism reproduction (GO:0032504)4.86400306
9positive regulation of synaptic transmission, GABAergic (GO:0032230)4.64415387
10negative regulation of heart rate (GO:0010459)4.61908670
11regulation of steroid hormone secretion (GO:2000831)4.53403210
12regulation of acrosome reaction (GO:0060046)4.48018563
13flavonoid metabolic process (GO:0009812)4.19773773
14cellular ketone body metabolic process (GO:0046950)3.96857018
15regulation of digestive system process (GO:0044058)3.86111166
16negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.85113874
17oocyte development (GO:0048599)3.82190725
18regulation of retinoic acid receptor signaling pathway (GO:0048385)3.62807779
19positive regulation of renal sodium excretion (GO:0035815)3.61851726
20regulation of action potential (GO:0098900)3.59142044
21meiotic cell cycle (GO:0051321)3.58516492
22male meiosis I (GO:0007141)3.58419671
23oxidative demethylation (GO:0070989)3.47985478
24ketone body metabolic process (GO:1902224)3.39982752
25negative regulation of hormone metabolic process (GO:0032351)3.33815887
26response to UV-C (GO:0010225)3.33038441
27protein K6-linked ubiquitination (GO:0085020)3.31820697
28negative regulation of protein activation cascade (GO:2000258)3.30994802
29binding of sperm to zona pellucida (GO:0007339)3.28099260
30negative regulation of hormone biosynthetic process (GO:0032353)3.26434964
31drug catabolic process (GO:0042737)3.26302013
32regulation of RIG-I signaling pathway (GO:0039535)3.24980956
33retinal cone cell development (GO:0046549)3.23998399
34indole-containing compound catabolic process (GO:0042436)3.19207807
35indolalkylamine catabolic process (GO:0046218)3.19207807
36tryptophan catabolic process (GO:0006569)3.19207807
37early endosome to late endosome transport (GO:0045022)3.14334812
38centriole replication (GO:0007099)3.14204886
39epoxygenase P450 pathway (GO:0019373)3.10392375
40single fertilization (GO:0007338)3.06050665
41regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.03703679
42phenylpropanoid metabolic process (GO:0009698)3.03092549
43sperm-egg recognition (GO:0035036)3.02378017
44reproduction (GO:0000003)3.01751377
45bile acid biosynthetic process (GO:0006699)3.01629150
46regulation of DNA endoreduplication (GO:0032875)3.00242610
47synaptonemal complex organization (GO:0070193)2.97630788
48omega-hydroxylase P450 pathway (GO:0097267)2.96389294
49establishment of protein localization to Golgi (GO:0072600)2.96256372
50centrosome duplication (GO:0051298)2.95789502
51water-soluble vitamin biosynthetic process (GO:0042364)2.95405017
52synaptonemal complex assembly (GO:0007130)2.94351126
53aromatic amino acid family catabolic process (GO:0009074)2.93453721
54positive regulation of protein autophosphorylation (GO:0031954)2.93061823
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.92902081
56L-phenylalanine metabolic process (GO:0006558)2.92902081
57regulation of female gonad development (GO:2000194)2.90229693
58bile acid metabolic process (GO:0008206)2.88802538
59respiratory tube development (GO:0030323)2.88526356
60meiosis I (GO:0007127)2.86375907
61sodium-independent organic anion transport (GO:0043252)2.84353966
62regulation of endocrine process (GO:0044060)2.84129492
63S-adenosylmethionine metabolic process (GO:0046500)2.84126675
64indolalkylamine metabolic process (GO:0006586)2.83963136
65negative regulation of complement activation (GO:0045916)2.81394352
66resolution of meiotic recombination intermediates (GO:0000712)2.79291733
67positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.78608347
68protein targeting to Golgi (GO:0000042)2.75929481
69fertilization (GO:0009566)2.75197378
70piRNA metabolic process (GO:0034587)2.75175191
71exogenous drug catabolic process (GO:0042738)2.75020834
72positive regulation of uterine smooth muscle contraction (GO:0070474)2.73960679
73protein K11-linked deubiquitination (GO:0035871)2.73567632
74cellular glucuronidation (GO:0052695)2.73236075
75protein K48-linked deubiquitination (GO:0071108)2.72669128
76gamma-aminobutyric acid transport (GO:0015812)2.72009477
77uronic acid metabolic process (GO:0006063)2.70254921
78glucuronate metabolic process (GO:0019585)2.70254921
79opsonization (GO:0008228)2.68843212
80regulation of female receptivity (GO:0045924)2.68473802
81regulation of exit from mitosis (GO:0007096)2.67534954
82positive regulation of meiotic cell cycle (GO:0051446)2.65718010
83positive regulation of meiosis (GO:0045836)2.65439553
84transcription from mitochondrial promoter (GO:0006390)2.64501974
85erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.64480375
86L-phenylalanine catabolic process (GO:0006559)2.64480375
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.64341106
88centrosome localization (GO:0051642)2.62304151
89protein localization to Golgi apparatus (GO:0034067)2.60893961
90regulation of fibrinolysis (GO:0051917)2.58389998
91negative regulation of keratinocyte proliferation (GO:0010839)2.57623087
92acrosome reaction (GO:0007340)2.56698458
93positive regulation of histone H3-K4 methylation (GO:0051571)2.56508188
94retrograde transport, vesicle recycling within Golgi (GO:0000301)2.53485444
95kynurenine metabolic process (GO:0070189)2.52344818
96positive regulation of endothelial cell differentiation (GO:0045603)2.52009380
97regulation of synaptic transmission, GABAergic (GO:0032228)2.51737815
98tryptophan metabolic process (GO:0006568)2.51278725
99protein K63-linked deubiquitination (GO:0070536)2.49655052
100aromatic amino acid family metabolic process (GO:0009072)2.49386769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.24747062
2VDR_22108803_ChIP-Seq_LS180_Human3.23037326
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.07023411
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.99860865
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.98235673
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.95964662
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91222294
8IGF1R_20145208_ChIP-Seq_DFB_Human2.64450560
9FUS_26573619_Chip-Seq_HEK293_Human2.49855875
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40944246
11ZNF274_21170338_ChIP-Seq_K562_Hela2.38929995
12EZH2_22144423_ChIP-Seq_EOC_Human2.35908582
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31745476
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28512117
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.27052257
16TAF15_26573619_Chip-Seq_HEK293_Human2.26733726
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.23298071
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21450578
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.10148574
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08602002
21SMAD4_21799915_ChIP-Seq_A2780_Human2.05919237
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02752046
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01919211
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.00111449
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96180972
26P300_19829295_ChIP-Seq_ESCs_Human1.91257870
27STAT3_23295773_ChIP-Seq_U87_Human1.83902821
28EWS_26573619_Chip-Seq_HEK293_Human1.82491743
29ER_23166858_ChIP-Seq_MCF-7_Human1.77336166
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76032555
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.68679648
32TCF4_23295773_ChIP-Seq_U87_Human1.68536003
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65016122
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59188235
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58804468
36CBP_20019798_ChIP-Seq_JUKART_Human1.57993408
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57993408
38FOXM1_26456572_ChIP-Seq_MCF-7_Human1.56275015
39AR_25329375_ChIP-Seq_VCAP_Human1.55522271
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53974500
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.52693356
42BCAT_22108803_ChIP-Seq_LS180_Human1.51348456
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.47207039
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42526007
45KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39440470
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38253626
47AHR_22903824_ChIP-Seq_MCF-7_Human1.37926574
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37878056
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37805539
50TCF4_22108803_ChIP-Seq_LS180_Human1.37456561
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34289953
52CBP_21632823_ChIP-Seq_H3396_Human1.34158275
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.33916570
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31388335
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30996339
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.30421734
57IRF1_19129219_ChIP-ChIP_H3396_Human1.25329392
58CDX2_22108803_ChIP-Seq_LS180_Human1.24948329
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24323485
60CJUN_26792858_Chip-Seq_BT549_Human1.23746690
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.23526855
62GATA4_25053715_ChIP-Seq_YYC3_Human1.22101716
63RUNX2_22187159_ChIP-Seq_PCA_Human1.21439260
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20678776
65TP53_16413492_ChIP-PET_HCT116_Human1.19313350
66ELK1_19687146_ChIP-ChIP_HELA_Human1.19242692
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18970012
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15588692
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15537780
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.15514885
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15213374
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14706383
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14418472
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14282442
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.10795073
76TP53_22573176_ChIP-Seq_HFKS_Human1.10654224
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.09869819
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.09696250
79TP63_23658742_ChIP-Seq_EP156T_Human1.08883603
80MYC_18940864_ChIP-ChIP_HL60_Human1.08382958
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07493410
82NANOG_19829295_ChIP-Seq_ESCs_Human1.06977910
83SOX2_19829295_ChIP-Seq_ESCs_Human1.06977910
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06428529
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06023132
86RNF2_27304074_Chip-Seq_NSC_Mouse1.05512931
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04150469
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04112241
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03645525
90KDM2B_26808549_Chip-Seq_REH_Human1.03079948
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.02616292
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.02329387
93TP53_18474530_ChIP-ChIP_U2OS_Human1.01100638
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01084640
95NCOR_22424771_ChIP-Seq_293T_Human0.99849630
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98809134
97GABP_17652178_ChIP-ChIP_JURKAT_Human0.98783817
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98458019
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97609823
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.95760949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.43871347
2MP0010386_abnormal_urinary_bladder4.13748458
3MP0001986_abnormal_taste_sensitivity4.07870302
4MP0003718_maternal_effect3.26922627
5MP0002138_abnormal_hepatobiliary_system2.81886537
6MP0005360_urolithiasis2.74152944
7MP0003879_abnormal_hair_cell2.51853284
8MP0005085_abnormal_gallbladder_physiolo2.44292505
9MP0008875_abnormal_xenobiotic_pharmacok2.44057608
10MP0006292_abnormal_olfactory_placode2.32163680
11MP0005410_abnormal_fertilization2.16056619
12MP0003195_calcinosis2.14522658
13MP0008877_abnormal_DNA_methylation2.09533870
14MP0003890_abnormal_embryonic-extraembry2.06878971
15MP0008057_abnormal_DNA_replication2.03216628
16MP0009780_abnormal_chondrocyte_physiolo1.93765893
17MP0008058_abnormal_DNA_repair1.90678074
18MP0003868_abnormal_feces_composition1.89569211
19MP0003252_abnormal_bile_duct1.86052350
20MP0003950_abnormal_plasma_membrane1.83757717
21MP0002160_abnormal_reproductive_system1.81757995
22MP0002234_abnormal_pharynx_morphology1.73490529
23MP0005670_abnormal_white_adipose1.73449877
24MP0000427_abnormal_hair_cycle1.72335486
25MP0003693_abnormal_embryo_hatching1.72053583
26MP0001929_abnormal_gametogenesis1.71447392
27MP0003119_abnormal_digestive_system1.68524766
28MP0002876_abnormal_thyroid_physiology1.68009349
29MP0003183_abnormal_peptide_metabolism1.66708629
30MP0005365_abnormal_bile_salt1.65990118
31MP0001666_abnormal_nutrient_absorption1.65078687
32MP0006054_spinal_hemorrhage1.52665701
33MP0004019_abnormal_vitamin_homeostasis1.50646025
34MP0005646_abnormal_pituitary_gland1.50479186
35MP0005551_abnormal_eye_electrophysiolog1.46945942
36MP0010329_abnormal_lipoprotein_level1.45990036
37MP0010094_abnormal_chromosome_stability1.44722051
38MP0000569_abnormal_digit_pigmentation1.43457006
39MP0002272_abnormal_nervous_system1.41572913
40MP0000647_abnormal_sebaceous_gland1.37106172
41MP0003699_abnormal_female_reproductive1.29377570
42MP0002210_abnormal_sex_determination1.27395350
43MP0006276_abnormal_autonomic_nervous1.26588055
44MP0001664_abnormal_digestion1.24036891
45MP0009840_abnormal_foam_cell1.15449328
46MP0004134_abnormal_chest_morphology1.15199048
47MP0000653_abnormal_sex_gland1.13580337
48MP0009046_muscle_twitch1.10899454
49MP0002090_abnormal_vision1.09708486
50MP0003698_abnormal_male_reproductive1.09417990
51MP0001486_abnormal_startle_reflex1.05139771
52MP0002734_abnormal_mechanical_nocicepti1.01337043
53MP0000678_abnormal_parathyroid_gland1.00711620
54MP0002751_abnormal_autonomic_nervous1.00140760
55MP0005647_abnormal_sex_gland0.99746811
56MP0008872_abnormal_physiological_respon0.99059930
57MP0001756_abnormal_urination0.97280084
58MP0004270_analgesia0.97189456
59MP0005266_abnormal_metabolism0.94262984
60MP0001984_abnormal_olfaction0.94081705
61MP0001145_abnormal_male_reproductive0.93664264
62MP0002161_abnormal_fertility/fecundity0.92682679
63MP0000631_abnormal_neuroendocrine_gland0.92258990
64MP0009697_abnormal_copulation0.92161206
65MP0003283_abnormal_digestive_organ0.91801761
66MP0001968_abnormal_touch/_nociception0.90375530
67MP0005395_other_phenotype0.89915865
68MP0001764_abnormal_homeostasis0.88977285
69MP0005408_hypopigmentation0.88606416
70MP0009745_abnormal_behavioral_response0.87734783
71MP0010234_abnormal_vibrissa_follicle0.86525036
72MP0004130_abnormal_muscle_cell0.86203112
73MP0005389_reproductive_system_phenotype0.85251195
74MP0002233_abnormal_nose_morphology0.84782734
75MP0009053_abnormal_anal_canal0.84201517
76MP0000358_abnormal_cell_content/0.84102829
77MP0002736_abnormal_nociception_after0.83616191
78MP0002089_abnormal_postnatal_growth/wei0.82864500
79MP0001485_abnormal_pinna_reflex0.79019285
80MP0004142_abnormal_muscle_tone0.78073503
81MP0005376_homeostasis/metabolism_phenot0.76754920
82MP0002184_abnormal_innervation0.76746575
83MP0002735_abnormal_chemical_nociception0.75894007
84MP0003077_abnormal_cell_cycle0.75727150
85MP0005187_abnormal_penis_morphology0.75450029
86MP0002332_abnormal_exercise_endurance0.74738365
87MP0001119_abnormal_female_reproductive0.74226201
88MP0003186_abnormal_redox_activity0.74202397
89MP0001970_abnormal_pain_threshold0.70280743
90MP0008789_abnormal_olfactory_epithelium0.69239015
91MP0003937_abnormal_limbs/digits/tail_de0.68546767
92MP0005332_abnormal_amino_acid0.67885221
93MP0001501_abnormal_sleep_pattern0.66042242
94MP0001502_abnormal_circadian_rhythm0.65393905
95MP0004215_abnormal_myocardial_fiber0.61601619
96MP0003880_abnormal_central_pattern0.60412418
97MP0009250_abnormal_appendicular_skeleto0.59676793
98MP0006072_abnormal_retinal_apoptosis0.57181179
99MP0008932_abnormal_embryonic_tissue0.56267610
100MP0002084_abnormal_developmental_patter0.56048583

Predicted human phenotypes

RankGene SetZ-score
1Conjugated hyperbilirubinemia (HP:0002908)4.58403486
2Aplasia/Hypoplasia of the tibia (HP:0005772)4.16411408
3Papillary thyroid carcinoma (HP:0002895)3.97511096
4Spontaneous abortion (HP:0005268)3.65202433
5Abnormality of methionine metabolism (HP:0010901)3.59711496
6Short tibia (HP:0005736)3.35120021
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.33637754
8Degeneration of the lateral corticospinal tracts (HP:0002314)3.33637754
9Epidermoid cyst (HP:0200040)3.20775085
10Abnormality of aspartate family amino acid metabolism (HP:0010899)3.18291132
11Gaze-evoked nystagmus (HP:0000640)3.16330041
12Intrahepatic cholestasis (HP:0001406)3.15195892
13Adrenal hypoplasia (HP:0000835)3.03526681
14Hypobetalipoproteinemia (HP:0003563)3.02905266
15Abnormality of aromatic amino acid family metabolism (HP:0004338)2.96630569
16Chronic hepatic failure (HP:0100626)2.96130300
17Congenital sensorineural hearing impairment (HP:0008527)2.83639178
18Renal cortical cysts (HP:0000803)2.82325277
19Genetic anticipation (HP:0003743)2.82126911
20Methylmalonic acidemia (HP:0002912)2.80470939
21Azoospermia (HP:0000027)2.79622059
22Fair hair (HP:0002286)2.76770606
23Prolonged partial thromboplastin time (HP:0003645)2.74394984
24Thyroid carcinoma (HP:0002890)2.71830851
25Hypophosphatemic rickets (HP:0004912)2.67451389
26Abnormality of the corticospinal tract (HP:0002492)2.66405478
27Abnormality of vitamin B metabolism (HP:0004340)2.65111457
28Pendular nystagmus (HP:0012043)2.65049331
29Abnormality of the vitamin B12 metabolism (HP:0004341)2.64126269
30Homocystinuria (HP:0002156)2.62296144
31Abnormality of homocysteine metabolism (HP:0010919)2.62296144
32Premature ovarian failure (HP:0008209)2.59011388
33Abnormality of chromosome stability (HP:0003220)2.56467214
34Male infertility (HP:0003251)2.54878216
35Agitation (HP:0000713)2.52792789
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.52696678
37Chromsome breakage (HP:0040012)2.47685667
38Abnormality of the common coagulation pathway (HP:0010990)2.46693328
39Attenuation of retinal blood vessels (HP:0007843)2.45978835
40Abnormality of the nasal septum (HP:0000419)2.45739947
41Confusion (HP:0001289)2.40330521
42Hyperlipoproteinemia (HP:0010980)2.40195222
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.36969885
44Termporal pattern (HP:0011008)2.36437844
45Insidious onset (HP:0003587)2.36437844
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35311476
47Megaloblastic anemia (HP:0001889)2.33455362
48Pancreatic fibrosis (HP:0100732)2.32330429
49Chorioretinal atrophy (HP:0000533)2.31876906
50Proximal tubulopathy (HP:0000114)2.26937377
51Abnormal auditory evoked potentials (HP:0006958)2.25336231
52Abnormality of vitamin metabolism (HP:0100508)2.23497265
53Poikiloderma (HP:0001029)2.22830831
54Abnormal spermatogenesis (HP:0008669)2.19854219
55Abnormality of the preputium (HP:0100587)2.19318142
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.18264752
57Sensory axonal neuropathy (HP:0003390)2.16822467
58Neonatal respiratory distress (HP:0002643)2.16116260
59Hypolipoproteinemia (HP:0010981)2.12479563
60Decreased central vision (HP:0007663)2.09177032
61Hypokinesia (HP:0002375)2.09168074
62Abnormality of DNA repair (HP:0003254)2.05406126
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.04906763
64Metaphyseal dysplasia (HP:0100255)2.04520460
65Prominent nose (HP:0000448)2.04335863
66Truncal obesity (HP:0001956)2.02299221
67Fat malabsorption (HP:0002630)2.00479795
68Hypoglycemic coma (HP:0001325)1.99808798
69Median cleft lip (HP:0000161)1.99361419
70Aplasia/Hypoplasia of the uvula (HP:0010293)1.94157196
71Methylmalonic aciduria (HP:0012120)1.92214202
72Entropion (HP:0000621)1.90010562
73Meckel diverticulum (HP:0002245)1.89842685
74Submucous cleft hard palate (HP:0000176)1.89681150
75Progressive cerebellar ataxia (HP:0002073)1.88718046
76Tongue fasciculations (HP:0001308)1.87992805
77Steatorrhea (HP:0002570)1.87229250
78Disinhibition (HP:0000734)1.85752018
79Bony spicule pigmentary retinopathy (HP:0007737)1.85513210
80Medial flaring of the eyebrow (HP:0010747)1.80960210
81Abnormality of the ileum (HP:0001549)1.79928113
82Pancreatic cysts (HP:0001737)1.79254329
83Generalized hypopigmentation of hair (HP:0011358)1.77796221
843-Methylglutaconic aciduria (HP:0003535)1.75867252
85Hypoalphalipoproteinemia (HP:0003233)1.74480580
86Horizontal nystagmus (HP:0000666)1.74364958
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74023399
88Optic nerve hypoplasia (HP:0000609)1.73568354
89Poor coordination (HP:0002370)1.72344696
90Impaired vibratory sensation (HP:0002495)1.71479550
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70910369
92Generalized aminoaciduria (HP:0002909)1.70729809
93Abnormality of the renal cortex (HP:0011035)1.70558636
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68273952
95Abnormality of alanine metabolism (HP:0010916)1.68273952
96Hyperalaninemia (HP:0003348)1.68273952
97Severe muscular hypotonia (HP:0006829)1.67767501
98Impaired vibration sensation in the lower limbs (HP:0002166)1.67744550
99Upper limb muscle weakness (HP:0003484)1.67364054
100Urinary urgency (HP:0000012)1.67313775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.31086194
2PDK24.32948841
3MST1R3.83274862
4PBK3.13619886
5MAP3K92.72362851
6MET2.67233670
7STK162.49968175
8EPHA22.38845306
9STK38L2.36295781
10CDC72.28693329
11TRIM282.27964067
12STK391.87314840
13EPHA41.73667088
14STK241.71010270
15EIF2AK31.64228720
16LATS11.62494445
17ZAK1.60885246
18NEK61.59624467
19ACVR1B1.57683558
20MST41.49559122
21PINK11.49550392
22TAOK31.36585432
23BMPR1B1.34572419
24AKT31.33997692
25TNIK1.28106434
26MAP3K41.24855394
27BRAF1.23578880
28ADRBK21.22154969
29STK31.21104699
30WNK41.20766943
31INSRR1.15150166
32PRKD31.14448081
33PRKCE1.13503767
34GRK11.11117323
35PLK11.07527978
36BRSK21.04210838
37SRPK11.02780964
38PLK41.02203661
39PRKCI1.01336221
40LATS20.99170209
41AURKA0.98299517
42NTRK30.94222277
43CASK0.93017896
44DYRK30.90663969
45EIF2AK10.88254196
46LMTK20.87008751
47OXSR10.85165678
48VRK10.82791233
49NUAK10.82276554
50MAP2K70.78944368
51AURKB0.78788152
52TTK0.78751154
53MKNK20.78338306
54MAPK130.77560058
55ARAF0.76075213
56CHEK20.74990055
57CDK90.74627495
58ERBB30.74399340
59BCR0.74300417
60PLK30.71956711
61ERBB40.71043305
62CAMK2A0.64849030
63BUB10.64706505
64MAP3K30.64233386
65FLT30.64194490
66WNK30.61148548
67RPS6KA40.58589004
68CDK120.57289079
69PIK3CG0.56801276
70CHEK10.56049628
71BMX0.53118702
72PRKD20.51822154
73CAMK2B0.51450843
74RPS6KA50.51124637
75FER0.50769046
76CSNK1G10.49543092
77PKN10.48974135
78TLK10.48382678
79PRKACB0.47917596
80MAP3K120.45677470
81AKT20.45450517
82SIK30.45391513
83MAP3K50.45138700
84CAMK2G0.42007910
85PLK20.40357256
86MKNK10.40131543
87ATM0.39670839
88MELK0.39551465
89ABL20.39518880
90CSNK1E0.38778550
91MAPKAPK30.38237030
92GSK3A0.35660203
93PHKG20.35554280
94PHKG10.35554280
95CAMKK20.34981969
96PRKG20.34393505
97CAMK40.34045743
98PRKACA0.33939049
99CSNK1G20.33099097
100PRKG10.33048556

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.42204132
2Caffeine metabolism_Homo sapiens_hsa002323.04322065
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.99921516
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.59440070
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.31163009
6Basal transcription factors_Homo sapiens_hsa030222.28750731
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.25379752
8Steroid hormone biosynthesis_Homo sapiens_hsa001402.23506919
9Chemical carcinogenesis_Homo sapiens_hsa052042.23233613
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22838635
11Retinol metabolism_Homo sapiens_hsa008302.22191505
12Nicotine addiction_Homo sapiens_hsa050332.12685067
13Non-homologous end-joining_Homo sapiens_hsa034502.09759241
14Butanoate metabolism_Homo sapiens_hsa006502.06603595
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.98098511
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93097866
17Sulfur metabolism_Homo sapiens_hsa009201.91952506
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91166469
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.72880017
20Complement and coagulation cascades_Homo sapiens_hsa046101.72442407
21Tryptophan metabolism_Homo sapiens_hsa003801.65321548
22Homologous recombination_Homo sapiens_hsa034401.54575994
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.50522398
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42829706
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42131099
26Fanconi anemia pathway_Homo sapiens_hsa034601.39352793
27Linoleic acid metabolism_Homo sapiens_hsa005911.35651913
28ABC transporters_Homo sapiens_hsa020101.33925823
29Starch and sucrose metabolism_Homo sapiens_hsa005001.33441759
30Selenocompound metabolism_Homo sapiens_hsa004501.32831589
31Sphingolipid metabolism_Homo sapiens_hsa006001.28893405
32Olfactory transduction_Homo sapiens_hsa047401.25938494
33Taste transduction_Homo sapiens_hsa047421.25082440
34* Bile secretion_Homo sapiens_hsa049761.23668327
35Systemic lupus erythematosus_Homo sapiens_hsa053221.22286021
36Fatty acid degradation_Homo sapiens_hsa000711.21883947
37Vitamin digestion and absorption_Homo sapiens_hsa049771.15972668
38Fatty acid elongation_Homo sapiens_hsa000621.12915732
39Circadian rhythm_Homo sapiens_hsa047101.10370193
40Nitrogen metabolism_Homo sapiens_hsa009101.08123060
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07967284
42PPAR signaling pathway_Homo sapiens_hsa033201.06363878
43beta-Alanine metabolism_Homo sapiens_hsa004101.04496167
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01035618
45Peroxisome_Homo sapiens_hsa041460.99927188
46RNA polymerase_Homo sapiens_hsa030200.98544670
47Fatty acid biosynthesis_Homo sapiens_hsa000610.97970379
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96968775
49Glycerolipid metabolism_Homo sapiens_hsa005610.95917767
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93804614
51Arachidonic acid metabolism_Homo sapiens_hsa005900.88383706
52Alcoholism_Homo sapiens_hsa050340.87693651
53Synaptic vesicle cycle_Homo sapiens_hsa047210.87639832
54Glutathione metabolism_Homo sapiens_hsa004800.84226465
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82375299
56Propanoate metabolism_Homo sapiens_hsa006400.82161623
57Oocyte meiosis_Homo sapiens_hsa041140.81121334
58Pyruvate metabolism_Homo sapiens_hsa006200.78193802
59Folate biosynthesis_Homo sapiens_hsa007900.77483194
60RNA transport_Homo sapiens_hsa030130.75889953
61Glutamatergic synapse_Homo sapiens_hsa047240.75465463
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74466936
63Fat digestion and absorption_Homo sapiens_hsa049750.74039846
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69852624
65Fatty acid metabolism_Homo sapiens_hsa012120.69682878
66Phototransduction_Homo sapiens_hsa047440.69485231
67Nucleotide excision repair_Homo sapiens_hsa034200.69160054
68Histidine metabolism_Homo sapiens_hsa003400.68271085
69Purine metabolism_Homo sapiens_hsa002300.67675399
70p53 signaling pathway_Homo sapiens_hsa041150.67411548
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66891659
72Pyrimidine metabolism_Homo sapiens_hsa002400.65422923
73Vitamin B6 metabolism_Homo sapiens_hsa007500.63869175
74RNA degradation_Homo sapiens_hsa030180.61996232
75Dorso-ventral axis formation_Homo sapiens_hsa043200.59232016
76Regulation of autophagy_Homo sapiens_hsa041400.59094415
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58112400
78Hippo signaling pathway_Homo sapiens_hsa043900.57165859
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53869401
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52909420
81Arginine biosynthesis_Homo sapiens_hsa002200.52330418
82GABAergic synapse_Homo sapiens_hsa047270.50696763
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50153471
84Cell cycle_Homo sapiens_hsa041100.48764919
85Metabolic pathways_Homo sapiens_hsa011000.48277975
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47417859
87Mismatch repair_Homo sapiens_hsa034300.46036855
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45184168
89Inositol phosphate metabolism_Homo sapiens_hsa005620.44736135
90Ovarian steroidogenesis_Homo sapiens_hsa049130.44143736
91Arginine and proline metabolism_Homo sapiens_hsa003300.43306611
92DNA replication_Homo sapiens_hsa030300.42554903
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42443276
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41989358
95Tyrosine metabolism_Homo sapiens_hsa003500.41455355
96Serotonergic synapse_Homo sapiens_hsa047260.40879913
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38689356
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37748074
99Protein export_Homo sapiens_hsa030600.35208295
100Morphine addiction_Homo sapiens_hsa050320.33681097

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