SLC9C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ventricular system development (GO:0021591)7.99123819
2sperm motility (GO:0030317)6.77622625
3axoneme assembly (GO:0035082)6.69731428
4regulation of cilium movement (GO:0003352)6.54926372
5intraciliary transport (GO:0042073)6.05860579
6cilium organization (GO:0044782)5.69305032
7cilium assembly (GO:0042384)5.58573424
8left/right axis specification (GO:0070986)5.58304976
9acrosome reaction (GO:0007340)4.72155186
10cilium morphogenesis (GO:0060271)4.64321525
11left/right pattern formation (GO:0060972)4.47296075
12sperm capacitation (GO:0048240)4.47261526
13negative regulation of inclusion body assembly (GO:0090084)4.45315448
14cellular component assembly involved in morphogenesis (GO:0010927)4.44666172
15multicellular organism reproduction (GO:0032504)4.34029704
16spermatid development (GO:0007286)4.33712172
17protein localization to cilium (GO:0061512)4.19836625
18protein polyglutamylation (GO:0018095)4.16851839
19microtubule-based movement (GO:0007018)4.06666374
20microtubule depolymerization (GO:0007019)3.96415707
21microtubule bundle formation (GO:0001578)3.91923012
22regulation of microtubule-based movement (GO:0060632)3.75162504
23photoreceptor cell maintenance (GO:0045494)3.72624129
24intra-S DNA damage checkpoint (GO:0031573)3.68976722
25microtubule polymerization or depolymerization (GO:0031109)3.68295040
26one-carbon compound transport (GO:0019755)3.67787819
27sperm-egg recognition (GO:0035036)3.60329129
28cell projection assembly (GO:0030031)3.57862211
29imidazole-containing compound metabolic process (GO:0052803)3.49801507
30determination of left/right symmetry (GO:0007368)3.40292223
31retinal rod cell development (GO:0046548)3.40285015
32regulation of interleukin-5 production (GO:0032674)3.38357774
33binding of sperm to zona pellucida (GO:0007339)3.37226724
34centriole assembly (GO:0098534)3.35877530
35single fertilization (GO:0007338)3.30335941
36regulation of phosphoprotein phosphatase activity (GO:0043666)3.30261458
37determination of bilateral symmetry (GO:0009855)3.25432734
38regulation of interleukin-13 production (GO:0032656)3.24088553
39fusion of sperm to egg plasma membrane (GO:0007342)3.20534605
40microtubule severing (GO:0051013)3.20044581
41gamma-aminobutyric acid transport (GO:0015812)3.19432543
42specification of symmetry (GO:0009799)3.18255953
43reproduction (GO:0000003)3.16411086
44indole-containing compound catabolic process (GO:0042436)3.15117181
45indolalkylamine catabolic process (GO:0046218)3.15117181
46tryptophan catabolic process (GO:0006569)3.15117181
47sex differentiation (GO:0007548)3.07339629
48nonmotile primary cilium assembly (GO:0035058)3.05094017
49smoothened signaling pathway (GO:0007224)3.00811726
50acrosome assembly (GO:0001675)2.99523263
51regulation of inclusion body assembly (GO:0090083)2.99061838
52cell-cell recognition (GO:0009988)2.98951976
53interkinetic nuclear migration (GO:0022027)2.81639126
54phosphatidylethanolamine biosynthetic process (GO:0006646)2.79782023
55lateral ventricle development (GO:0021670)2.77702075
56regulation of cilium assembly (GO:1902017)2.76514743
57phosphatidylethanolamine metabolic process (GO:0046337)2.74712819
58organic cation transport (GO:0015695)2.68416644
59negative regulation of cytosolic calcium ion concentration (GO:0051481)2.67693432
60organelle assembly (GO:0070925)2.66156820
61limb development (GO:0060173)2.65950485
62appendage development (GO:0048736)2.65950485
63ADP metabolic process (GO:0046031)2.65222290
64regulation of establishment of cell polarity (GO:2000114)2.64748127
65microtubule-based process (GO:0007017)2.58166128
66single strand break repair (GO:0000012)2.57859812
67positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.57366588
68coenzyme catabolic process (GO:0009109)2.55784442
69cranial nerve morphogenesis (GO:0021602)2.54144148
70nucleoside diphosphate phosphorylation (GO:0006165)2.53551172
71spermatogenesis (GO:0007283)2.52746149
72male gamete generation (GO:0048232)2.52028647
73tryptophan metabolic process (GO:0006568)2.51032442
74regulation of autophagic vacuole assembly (GO:2000785)2.48876171
75male meiosis (GO:0007140)2.48782875
76calcium ion-dependent exocytosis (GO:0017156)2.48524351
77response to pheromone (GO:0019236)2.47699175
78membrane depolarization during action potential (GO:0086010)2.46986621
79fertilization (GO:0009566)2.45286374
80androgen biosynthetic process (GO:0006702)2.45011500
81negative regulation of multicellular organism growth (GO:0040015)2.44966824
82positive regulation of catecholamine secretion (GO:0033605)2.41865872
83centriole replication (GO:0007099)2.41379617
84gamete generation (GO:0007276)2.36304089
85regulation of smoothened signaling pathway (GO:0008589)2.35058444
86germ cell development (GO:0007281)2.34666117
87retinal cone cell development (GO:0046549)2.34257196
88regulation of vacuole organization (GO:0044088)2.33275408
89plasma membrane fusion (GO:0045026)2.32360573
90glomerular epithelial cell development (GO:0072310)2.32224882
91auditory behavior (GO:0031223)2.30462998
92spermatid nucleus differentiation (GO:0007289)2.29916733
93cell wall macromolecule metabolic process (GO:0044036)2.28982002
94regulation of action potential (GO:0098900)2.27238460
95cilium or flagellum-dependent cell motility (GO:0001539)15.5139001
96axonemal dynein complex assembly (GO:0070286)14.4603353
97cilium movement (GO:0003341)13.0237905
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.9611826
99motile cilium assembly (GO:0044458)11.0509181
100epithelial cilium movement (GO:0003351)10.6541217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.26300720
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.05082702
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.29466715
4IGF1R_20145208_ChIP-Seq_DFB_Human3.03245981
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.90427953
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.83969983
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.65034806
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62524949
9FUS_26573619_Chip-Seq_HEK293_Human2.41423743
10EZH2_22144423_ChIP-Seq_EOC_Human2.35425858
11VDR_22108803_ChIP-Seq_LS180_Human2.29686671
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23565109
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16656429
14TAF15_26573619_Chip-Seq_HEK293_Human2.11353865
15AR_21572438_ChIP-Seq_LNCaP_Human2.08810219
16SMAD4_21799915_ChIP-Seq_A2780_Human2.07784804
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05519721
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02981061
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93556142
20DROSHA_22980978_ChIP-Seq_HELA_Human1.91930324
21STAT3_23295773_ChIP-Seq_U87_Human1.91213177
22P300_19829295_ChIP-Seq_ESCs_Human1.85902133
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84013464
24CBP_20019798_ChIP-Seq_JUKART_Human1.81106207
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.81106207
26ER_23166858_ChIP-Seq_MCF-7_Human1.80532737
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79998256
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79998256
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79235258
30BCAT_22108803_ChIP-Seq_LS180_Human1.76877531
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.74147049
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.69549737
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.67602925
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67350683
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66263538
36TCF4_23295773_ChIP-Seq_U87_Human1.62659599
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62135420
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61054459
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56336897
40AHR_22903824_ChIP-Seq_MCF-7_Human1.54123862
41AR_25329375_ChIP-Seq_VCAP_Human1.50718946
42RUNX2_22187159_ChIP-Seq_PCA_Human1.49322540
43TP53_18474530_ChIP-ChIP_U2OS_Human1.49297551
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48014844
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45830650
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42988583
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36181792
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35897535
49ZNF274_21170338_ChIP-Seq_K562_Hela1.33082529
50TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31807307
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31379719
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.31189783
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30373600
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29532411
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28145506
56SMAD4_21741376_ChIP-Seq_EPCs_Human1.26182801
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.26033745
58TBL1_22424771_ChIP-Seq_293T_Human1.25339960
59TCF4_22108803_ChIP-Seq_LS180_Human1.24701273
60WDR5_24793694_ChIP-Seq_LNCAP_Human1.20858611
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17339306
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16670647
63EWS_26573619_Chip-Seq_HEK293_Human1.16518910
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.14783775
65ETV1_20927104_ChIP-Seq_GIST48_Human1.13649945
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.12147905
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11860698
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11275078
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.10649049
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10462172
71NFYB_21822215_ChIP-Seq_K562_Human1.08970887
72OCT1_27270436_Chip-Seq_PROSTATE_Human1.06990389
73PHF8_20622853_ChIP-Seq_HELA_Human1.06716366
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06014268
75REST_21632747_ChIP-Seq_MESCs_Mouse1.05496949
76AR_19668381_ChIP-Seq_PC3_Human1.05133953
77RXR_22108803_ChIP-Seq_LS180_Human1.04723285
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03869227
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.03413863
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02767912
81SOX2_19829295_ChIP-Seq_ESCs_Human1.02336276
82NANOG_19829295_ChIP-Seq_ESCs_Human1.02336276
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.01859679
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01435606
85SMAD3_21741376_ChIP-Seq_ESCs_Human1.01278979
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01008410
87CDX2_22108803_ChIP-Seq_LS180_Human0.99817035
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99619337
89TP53_16413492_ChIP-PET_HCT116_Human0.99516269
90TP63_23658742_ChIP-Seq_EP156T_Human0.98623238
91NFYA_21822215_ChIP-Seq_K562_Human0.98309641
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96544731
93ERA_21632823_ChIP-Seq_H3396_Human0.96458534
94SMRT_27268052_Chip-Seq_Bcells_Human0.95972168
95ERG_20517297_ChIP-Seq_VCAP_Human0.95155740
96CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95000627
97OCT4_20526341_ChIP-Seq_ESCs_Human0.94521306
98HNFA_21074721_ChIP-Seq_CACO-2_Human0.94491962
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94423032
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92258545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.82263500
2MP0000569_abnormal_digit_pigmentation5.62654101
3MP0005410_abnormal_fertilization4.22835404
4MP0005623_abnormal_meninges_morphology3.41000373
5MP0001984_abnormal_olfaction3.10422734
6MP0005423_abnormal_somatic_nervous2.71890629
7MP0001485_abnormal_pinna_reflex2.50923184
8MP0003698_abnormal_male_reproductive2.23426080
9MP0002282_abnormal_trachea_morphology2.20137932
10MP0003136_yellow_coat_color2.16403138
11MP0009046_muscle_twitch2.12334423
12MP0003879_abnormal_hair_cell2.09161429
13MP0002132_abnormal_respiratory_system2.07693429
14MP0003880_abnormal_central_pattern2.01386411
15MP0003011_delayed_dark_adaptation1.98665479
16MP0005646_abnormal_pituitary_gland1.96783834
17MP0000566_synostosis1.82739123
18MP0001529_abnormal_vocalization1.79793912
19MP0003878_abnormal_ear_physiology1.79569177
20MP0005377_hearing/vestibular/ear_phenot1.79569177
21MP0001929_abnormal_gametogenesis1.71403970
22MP0004859_abnormal_synaptic_plasticity1.70707320
23MP0002638_abnormal_pupillary_reflex1.69254923
24MP0005253_abnormal_eye_physiology1.63808235
25MP0005551_abnormal_eye_electrophysiolog1.63483623
26MP0001968_abnormal_touch/_nociception1.63133710
27MP0001486_abnormal_startle_reflex1.59285383
28MP0005174_abnormal_tail_pigmentation1.55140463
29MP0010386_abnormal_urinary_bladder1.54209963
30MP0002160_abnormal_reproductive_system1.54199376
31MP0000026_abnormal_inner_ear1.47815303
32MP0002736_abnormal_nociception_after1.45299372
33MP0004133_heterotaxia1.39219933
34MP0004742_abnormal_vestibular_system1.36611861
35MP0002734_abnormal_mechanical_nocicepti1.35100864
36MP0002572_abnormal_emotion/affect_behav1.34643930
37MP0004270_analgesia1.31741138
38MP0005499_abnormal_olfactory_system1.31141590
39MP0005394_taste/olfaction_phenotype1.31141590
40MP0008875_abnormal_xenobiotic_pharmacok1.30062386
41MP0003633_abnormal_nervous_system1.24505342
42MP0002272_abnormal_nervous_system1.21152422
43MP0009745_abnormal_behavioral_response1.20967290
44MP0008789_abnormal_olfactory_epithelium1.20912850
45MP0004147_increased_porphyrin_level1.20675955
46MP0002161_abnormal_fertility/fecundity1.19182239
47MP0000383_abnormal_hair_follicle1.19162937
48MP0000631_abnormal_neuroendocrine_gland1.18511295
49MP0001970_abnormal_pain_threshold1.15827843
50MP0002735_abnormal_chemical_nociception1.12333614
51MP0001963_abnormal_hearing_physiology1.11808031
52MP0001293_anophthalmia1.10451436
53MP0003635_abnormal_synaptic_transmissio1.10334882
54MP0000427_abnormal_hair_cycle1.10120168
55MP0001501_abnormal_sleep_pattern1.08213143
56MP0005391_vision/eye_phenotype1.07258195
57MP0003252_abnormal_bile_duct1.05935640
58MP0003718_maternal_effect1.02670975
59MP0002822_catalepsy1.01808676
60MP0001905_abnormal_dopamine_level1.01372035
61MP0003315_abnormal_perineum_morphology1.00787570
62MP0008004_abnormal_stomach_pH1.00738900
63MP0003890_abnormal_embryonic-extraembry1.00114879
64MP0000778_abnormal_nervous_system1.00003698
65MP0004043_abnormal_pH_regulation0.98280374
66MP0002249_abnormal_larynx_morphology0.98101456
67MP0002067_abnormal_sensory_capabilities0.98078513
68MP0005389_reproductive_system_phenotype0.96287499
69MP0001986_abnormal_taste_sensitivity0.96096867
70MP0002210_abnormal_sex_determination0.94673127
71MP0006276_abnormal_autonomic_nervous0.94219115
72MP0002229_neurodegeneration0.93510090
73MP0003937_abnormal_limbs/digits/tail_de0.93268235
74MP0003631_nervous_system_phenotype0.90807095
75MP0010030_abnormal_orbit_morphology0.89874780
76MP0002063_abnormal_learning/memory/cond0.88783665
77MP0000955_abnormal_spinal_cord0.87118474
78MP0002064_seizures0.86622738
79MP0002233_abnormal_nose_morphology0.86268890
80MP0005647_abnormal_sex_gland0.85049234
81MP0001145_abnormal_male_reproductive0.83657852
82MP0005670_abnormal_white_adipose0.83149879
83MP0002882_abnormal_neuron_morphology0.80375811
84MP0006072_abnormal_retinal_apoptosis0.80146994
85MP0005248_abnormal_Harderian_gland0.79056646
86MP0002752_abnormal_somatic_nervous0.77446963
87MP0002557_abnormal_social/conspecific_i0.76191674
88MP0000653_abnormal_sex_gland0.75791116
89MP0001664_abnormal_digestion0.75584353
90MP0000049_abnormal_middle_ear0.75405003
91MP0002733_abnormal_thermal_nociception0.75219821
92MP0002277_abnormal_respiratory_mucosa0.75154736
93MP0005195_abnormal_posterior_eye0.74615651
94MP0002928_abnormal_bile_duct0.74442746
95MP0001502_abnormal_circadian_rhythm0.74420312
96MP0003938_abnormal_ear_development0.71905538
97MP0001919_abnormal_reproductive_system0.71076357
98MP0003119_abnormal_digestive_system0.70898575
99MP0002102_abnormal_ear_morphology0.70497040
100MP0005395_other_phenotype0.66398038

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.73868935
2Abnormal respiratory motile cilium physiology (HP:0012261)9.57779690
3Absent/shortened dynein arms (HP:0200106)9.17661746
4Dynein arm defect of respiratory motile cilia (HP:0012255)9.17661746
5Abnormal respiratory motile cilium morphology (HP:0005938)7.95178750
6Abnormal respiratory epithelium morphology (HP:0012253)7.95178750
7Rhinitis (HP:0012384)7.88218976
8Chronic bronchitis (HP:0004469)5.99814264
9Nasal polyposis (HP:0100582)5.64944480
10Chronic hepatic failure (HP:0100626)5.45970217
11Bronchiectasis (HP:0002110)5.39096207
12Occipital encephalocele (HP:0002085)4.95669019
13Pancreatic fibrosis (HP:0100732)4.67255917
14Abnormality of the nasal mucosa (HP:0000433)4.59847762
15True hermaphroditism (HP:0010459)4.23200177
16Recurrent sinusitis (HP:0011108)4.16479570
17Pancreatic cysts (HP:0001737)3.94866792
18Tubular atrophy (HP:0000092)3.62017650
19Cystic liver disease (HP:0006706)3.57147531
20Nephronophthisis (HP:0000090)3.56656395
21Abnormal biliary tract physiology (HP:0012439)3.52143150
22Bile duct proliferation (HP:0001408)3.52143150
23Bronchitis (HP:0012387)3.47433315
24Molar tooth sign on MRI (HP:0002419)3.19462408
25Abnormality of midbrain morphology (HP:0002418)3.19462408
26Recurrent otitis media (HP:0000403)3.09281190
27Infertility (HP:0000789)2.99813114
28Abnormality of the renal medulla (HP:0100957)2.99028920
29Bell-shaped thorax (HP:0001591)2.88837566
30Abnormal drinking behavior (HP:0030082)2.80863211
31Polydipsia (HP:0001959)2.80863211
32Genetic anticipation (HP:0003743)2.74067694
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.63736294
34Progressive cerebellar ataxia (HP:0002073)2.63210377
35Postaxial foot polydactyly (HP:0001830)2.57629827
36Anencephaly (HP:0002323)2.51559004
37Tubulointerstitial nephritis (HP:0001970)2.46701395
38Congenital hepatic fibrosis (HP:0002612)2.45275541
39Sclerocornea (HP:0000647)2.44797134
40Medial flaring of the eyebrow (HP:0010747)2.40974071
41Chronic sinusitis (HP:0011109)2.40680198
42Male pseudohermaphroditism (HP:0000037)2.39428423
43Abnormality of the renal cortex (HP:0011035)2.37426187
44Gait imbalance (HP:0002141)2.33530682
45Congenital primary aphakia (HP:0007707)2.33350936
46Bony spicule pigmentary retinopathy (HP:0007737)2.06164866
47Genital tract atresia (HP:0001827)2.04076942
48Nephrogenic diabetes insipidus (HP:0009806)2.03184422
49Abnormality of the hepatic vasculature (HP:0006707)2.00571058
50Oculomotor apraxia (HP:0000657)2.00484521
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.1262674
52Vaginal atresia (HP:0000148)1.93520065
53Polyuria (HP:0000103)1.91493522
54Male infertility (HP:0003251)1.91010662
55Furrowed tongue (HP:0000221)1.88522997
56Postaxial hand polydactyly (HP:0001162)1.84157771
57Abnormality of macular pigmentation (HP:0008002)1.82419237
58Renal dysplasia (HP:0000110)1.81662369
59Intellectual disability, moderate (HP:0002342)1.80980458
60Preaxial hand polydactyly (HP:0001177)1.79955158
61Poor coordination (HP:0002370)1.77415129
62Stage 5 chronic kidney disease (HP:0003774)1.75456323
63Anophthalmia (HP:0000528)1.74126097
64Abnormal rod and cone electroretinograms (HP:0008323)1.74032588
65Recurrent bronchitis (HP:0002837)1.73921413
66Abnormal urine output (HP:0012590)1.71227149
67Tubulointerstitial abnormality (HP:0001969)1.68790104
68Type II lissencephaly (HP:0007260)1.67433550
69Action tremor (HP:0002345)1.66536655
70Postural instability (HP:0002172)1.64491596
71Absent rod-and cone-mediated responses on ERG (HP:0007688)1.64463428
72Portal hypertension (HP:0001409)1.64456295
73Optic nerve coloboma (HP:0000588)1.58856079
74Median cleft lip (HP:0000161)1.58805539
75Atonic seizures (HP:0010819)1.57872943
76Abnormality of renal excretion (HP:0011036)1.53003765
77Narrow forehead (HP:0000341)1.51949631
78Focal motor seizures (HP:0011153)1.49350906
79Dysmetric saccades (HP:0000641)1.49074897
80Gaze-evoked nystagmus (HP:0000640)1.47333410
81Retinitis pigmentosa (HP:0000510)1.45978897
82Atelectasis (HP:0100750)1.44389441
83Hypoplasia of the pons (HP:0012110)1.44066404
84Cone-rod dystrophy (HP:0000548)1.42495082
85Highly arched eyebrow (HP:0002553)1.42360597
86Retinal dysplasia (HP:0007973)1.41881659
87Absence seizures (HP:0002121)1.41498224
88Focal seizures (HP:0007359)1.39144313
89Hyperglycinemia (HP:0002154)1.37709124
90Febrile seizures (HP:0002373)1.36922345
91Dysdiadochokinesis (HP:0002075)1.36906518
92Cerebellar dysplasia (HP:0007033)1.35183503
93Prominent nasal bridge (HP:0000426)1.35050413
94Supernumerary spleens (HP:0009799)1.33543802
95Chronic otitis media (HP:0000389)1.33041131
96Aganglionic megacolon (HP:0002251)1.32635121
97Hyperventilation (HP:0002883)1.32406615
98Abnormality of the pons (HP:0007361)1.28980165
99Facial cleft (HP:0002006)1.26811489
100Aplasia/Hypoplasia of the lens (HP:0008063)1.26186197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.30511816
2PINK14.83185226
3FRK4.77427702
4PNCK4.62851460
5BMPR1B2.23669792
6WNK32.19302802
7PTK2B2.02920797
8CASK1.83760393
9PRKD31.83312612
10CDK191.65688341
11ZAK1.65382246
12MARK31.64990708
13TLK11.62856825
14STK38L1.61345923
15BRD41.60327222
16MST41.57650512
17EPHA41.51862799
18MYLK1.51446452
19OXSR11.49190654
20STK381.46843248
21MET1.44380084
22MAP2K71.40101894
23NTRK21.33401119
24MAP3K41.31544513
25RPS6KA51.27494233
26LATS11.26129820
27PLK41.23955643
28INSRR1.23490927
29CAMK1G1.16193107
30DYRK31.14492356
31BCR1.09646760
32MAPK131.05096436
33SGK2231.03600320
34SGK4941.03600320
35TNIK1.03010228
36WNK41.02098048
37GRK10.98632060
38MAP3K70.90583826
39ACVR1B0.89342670
40MUSK0.87823613
41PIK3CA0.87314641
42ERBB20.87268058
43PLK20.85545617
44ADRBK20.85119846
45NEK20.81696353
46CDK120.81474493
47CAMKK20.79337409
48CDK30.73697525
49NTRK30.69943457
50CSNK1A1L0.66500925
51TGFBR10.64667977
52DDR20.62891237
53PAK20.62624242
54CDK50.59096166
55STK110.58033180
56WEE10.57765384
57MARK10.56945823
58CAMK10.56535768
59EPHB10.55564586
60STK390.55432794
61CAMK40.55313037
62ROCK10.54533545
63CSNK1G20.54213861
64RET0.53235930
65STK30.52716031
66MAPKAPK50.50333911
67TNK20.50193656
68PRKG10.48563440
69SGK10.48205964
70CAMK2A0.46992726
71OBSCN0.46959234
72MST1R0.45384587
73FGFR20.44927977
74MAP4K20.44454994
75EPHA20.44029073
76PRKCG0.43375071
77PRKCQ0.43222326
78MAP3K20.42764265
79TIE10.42717033
80DYRK1A0.42712518
81SGK20.41001102
82PDPK10.40974242
83FGR0.39931234
84RPS6KA30.38136567
85ADRBK10.37874064
86WNK10.37197530
87MARK20.36830655
88MAPK100.35009620
89PDK10.34814339
90TSSK60.34283216
91AKT30.33802367
92CSNK1G10.33560314
93PRKACB0.33027466
94CSNK1A10.32235249
95PRKACA0.32185631
96DYRK20.31226903
97PKN10.29818388
98NME10.29251325
99MKNK20.28774828
100CCNB10.28570505

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.83019152
2Nicotine addiction_Homo sapiens_hsa050332.78274814
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.70916524
4Olfactory transduction_Homo sapiens_hsa047402.69728359
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.51142023
6Chemical carcinogenesis_Homo sapiens_hsa052042.36971715
7Butanoate metabolism_Homo sapiens_hsa006502.22959426
8Fatty acid biosynthesis_Homo sapiens_hsa000612.21959759
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.07675942
10Huntingtons disease_Homo sapiens_hsa050162.04803268
11Hedgehog signaling pathway_Homo sapiens_hsa043402.03332260
12Systemic lupus erythematosus_Homo sapiens_hsa053222.00935689
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.00114597
14Taste transduction_Homo sapiens_hsa047421.99198101
15ABC transporters_Homo sapiens_hsa020101.97454788
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95196919
17Histidine metabolism_Homo sapiens_hsa003401.89524559
18Alcoholism_Homo sapiens_hsa050341.74339955
19beta-Alanine metabolism_Homo sapiens_hsa004101.69859135
20Retinol metabolism_Homo sapiens_hsa008301.69031990
21Propanoate metabolism_Homo sapiens_hsa006401.68428665
22Tryptophan metabolism_Homo sapiens_hsa003801.63235416
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56378637
24Gap junction_Homo sapiens_hsa045401.54628352
25Linoleic acid metabolism_Homo sapiens_hsa005911.53593507
26Dorso-ventral axis formation_Homo sapiens_hsa043201.42968331
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38373935
28Nitrogen metabolism_Homo sapiens_hsa009101.36963273
29Morphine addiction_Homo sapiens_hsa050321.35018445
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31910989
31Phenylalanine metabolism_Homo sapiens_hsa003601.31119480
32GABAergic synapse_Homo sapiens_hsa047271.31058771
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28939538
34One carbon pool by folate_Homo sapiens_hsa006701.23553145
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20938862
36Salivary secretion_Homo sapiens_hsa049701.20804171
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19259773
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18774331
39Circadian entrainment_Homo sapiens_hsa047131.16943767
40Glutamatergic synapse_Homo sapiens_hsa047241.15864430
41Fatty acid degradation_Homo sapiens_hsa000711.15678128
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15412735
43Tyrosine metabolism_Homo sapiens_hsa003501.11529039
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09551203
45Peroxisome_Homo sapiens_hsa041461.07093438
46Glutathione metabolism_Homo sapiens_hsa004801.04522975
47Fanconi anemia pathway_Homo sapiens_hsa034600.98153461
48PPAR signaling pathway_Homo sapiens_hsa033200.96577602
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95513215
50Phototransduction_Homo sapiens_hsa047440.93015531
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.89890465
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89226695
53Caffeine metabolism_Homo sapiens_hsa002320.88772198
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85336369
55Bile secretion_Homo sapiens_hsa049760.82754856
56Calcium signaling pathway_Homo sapiens_hsa040200.81882987
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.81504718
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80398369
59Cardiac muscle contraction_Homo sapiens_hsa042600.78150215
60Gastric acid secretion_Homo sapiens_hsa049710.78087183
61cAMP signaling pathway_Homo sapiens_hsa040240.76503049
62Renin secretion_Homo sapiens_hsa049240.73440841
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70277062
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69859885
65Circadian rhythm_Homo sapiens_hsa047100.69225072
66Basal cell carcinoma_Homo sapiens_hsa052170.66372736
67Purine metabolism_Homo sapiens_hsa002300.65814814
68Arachidonic acid metabolism_Homo sapiens_hsa005900.63608532
69Sphingolipid metabolism_Homo sapiens_hsa006000.62941546
70Axon guidance_Homo sapiens_hsa043600.58934810
71Oxytocin signaling pathway_Homo sapiens_hsa049210.56305378
72Basal transcription factors_Homo sapiens_hsa030220.56104448
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54794267
74Fatty acid metabolism_Homo sapiens_hsa012120.53157758
75Glycerolipid metabolism_Homo sapiens_hsa005610.52518024
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51898599
77Insulin secretion_Homo sapiens_hsa049110.51767697
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51206393
79Serotonergic synapse_Homo sapiens_hsa047260.50114155
80Cocaine addiction_Homo sapiens_hsa050300.48872501
81Amphetamine addiction_Homo sapiens_hsa050310.48181148
82Metabolic pathways_Homo sapiens_hsa011000.46488691
83Tight junction_Homo sapiens_hsa045300.43942628
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43399674
85Hippo signaling pathway_Homo sapiens_hsa043900.42086241
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41225511
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40385428
88Ether lipid metabolism_Homo sapiens_hsa005650.40284151
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40104164
90Phagosome_Homo sapiens_hsa041450.38840010
91Pyruvate metabolism_Homo sapiens_hsa006200.37852827
92Selenocompound metabolism_Homo sapiens_hsa004500.37073782
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36952085
94Starch and sucrose metabolism_Homo sapiens_hsa005000.36247508
95Pancreatic secretion_Homo sapiens_hsa049720.34738732
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34242969
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33650515
98Lysine degradation_Homo sapiens_hsa003100.32569008
99Sulfur relay system_Homo sapiens_hsa041220.31716161
100Cholinergic synapse_Homo sapiens_hsa047250.31459102

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