SLC9C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family (see SLC9A1, MIM 107310) and is required for male fertility and sperm motility (Wang et al., 2003 [PubMed 14634667]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.88722473
2reproduction (GO:0000003)9.72087490
3male meiosis (GO:0007140)9.35323979
4motile cilium assembly (GO:0044458)9.27303399
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.97720633
6cilium movement (GO:0003341)8.96523898
7spermatid development (GO:0007286)8.95497429
8synaptonemal complex organization (GO:0070193)8.35998849
9synaptonemal complex assembly (GO:0007130)8.06911753
10single fertilization (GO:0007338)7.74513929
11regulation of cilium movement (GO:0003352)7.55499678
12sperm capacitation (GO:0048240)6.91227086
13DNA methylation involved in gamete generation (GO:0043046)6.70967660
14fertilization (GO:0009566)6.54845170
15male meiosis I (GO:0007141)5.93613614
16chromosome organization involved in meiosis (GO:0070192)5.73661423
17establishment of protein localization to Golgi (GO:0072600)5.68617622
18protein targeting to Golgi (GO:0000042)5.63047368
19* spermatogenesis (GO:0007283)5.61391140
20ventricular system development (GO:0021591)5.60760243
21* male gamete generation (GO:0048232)5.59339605
22negative regulation of inclusion body assembly (GO:0090084)5.59335552
23retrograde transport, vesicle recycling within Golgi (GO:0000301)5.49589909
24meiotic nuclear division (GO:0007126)5.32919506
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.24769820
26germ cell development (GO:0007281)5.19257700
27* gamete generation (GO:0007276)5.14394550
28microtubule depolymerization (GO:0007019)5.02374384
29regulation of type B pancreatic cell apoptotic process (GO:2000674)4.90406334
30cell recognition (GO:0008037)4.89284570
31meiosis I (GO:0007127)4.79879183
32seminiferous tubule development (GO:0072520)4.76604279
33organic cation transport (GO:0015695)4.69191853
34monoubiquitinated protein deubiquitination (GO:0035520)4.62408872
35calcium ion-dependent exocytosis (GO:0017156)4.61361784
36regulation of inclusion body assembly (GO:0090083)4.55873505
37meiotic cell cycle (GO:0051321)4.54241965
38protein localization to cilium (GO:0061512)4.49841610
39microtubule severing (GO:0051013)4.49390343
40regulation of microtubule-based movement (GO:0060632)4.42116009
41protein localization to Golgi apparatus (GO:0034067)4.28171659
42spermatid nucleus differentiation (GO:0007289)4.26035310
43genitalia morphogenesis (GO:0035112)4.14305457
44* multicellular organismal reproductive process (GO:0048609)4.03774978
45diterpenoid biosynthetic process (GO:0016102)3.99075770
46left/right pattern formation (GO:0060972)3.97670931
47gene silencing by RNA (GO:0031047)3.96928638
48intraciliary transport (GO:0042073)3.92962970
49auditory receptor cell differentiation (GO:0042491)3.78885479
50intra-Golgi vesicle-mediated transport (GO:0006891)3.70541302
51regulation of transmission of nerve impulse (GO:0051969)3.69082193
52chaperone-mediated protein complex assembly (GO:0051131)3.55415668
53lactate metabolic process (GO:0006089)3.54179409
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.53170107
55protein polyglutamylation (GO:0018095)3.52692582
56negative regulation of gluconeogenesis (GO:0045721)3.51522530
57synapsis (GO:0007129)3.49651964
58negative regulation of organelle assembly (GO:1902116)3.48824772
59microtubule-based movement (GO:0007018)3.47963349
60glycerol ether metabolic process (GO:0006662)3.45898924
61regulation of centriole replication (GO:0046599)3.44536864
62axoneme assembly (GO:0035082)3.42538932
63terpenoid biosynthetic process (GO:0016114)3.35616198
64meiotic cell cycle process (GO:1903046)3.33598743
65regulation of protein polyubiquitination (GO:1902914)3.29850480
66alditol metabolic process (GO:0019400)3.28830154
67* multicellular organismal development (GO:0007275)3.28277308
68keratinocyte development (GO:0003334)3.26675595
69insulin secretion (GO:0030073)3.24952009
70response to pheromone (GO:0019236)3.24363823
71protein K11-linked deubiquitination (GO:0035871)3.22770004
72centriole replication (GO:0007099)3.21571655
73cilium organization (GO:0044782)3.20431970
74ether metabolic process (GO:0018904)3.19203220
75centriole assembly (GO:0098534)3.13470019
76peptide hormone processing (GO:0016486)3.13136093
77carnitine transmembrane transport (GO:1902603)3.12883857
78amino-acid betaine transport (GO:0015838)3.12642865
79carnitine transport (GO:0015879)3.12642865
80snRNA transcription (GO:0009301)3.11429833
81regulation of meiosis I (GO:0060631)3.09778365
82endocrine pancreas development (GO:0031018)3.09416223
83nuclear pore complex assembly (GO:0051292)3.09060774
84nucleoside diphosphate phosphorylation (GO:0006165)3.06994013
85positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.06930957
86cilium assembly (GO:0042384)3.04499181
87regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.02070288
88polyol catabolic process (GO:0046174)3.00103563
89cellular component assembly involved in morphogenesis (GO:0010927)2.99442536
90negative regulation of protein localization to cell surface (GO:2000009)2.98982436
91glycerol metabolic process (GO:0006071)2.98704947
92photoreceptor cell maintenance (GO:0045494)2.95526792
93regulation of acrosome reaction (GO:0060046)2.94280188
94regulation of axon regeneration (GO:0048679)2.94073558
95regulation of neuron projection regeneration (GO:0070570)2.94073558
96positive regulation of protein autophosphorylation (GO:0031954)2.93915871
97positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.93854838
98GTP biosynthetic process (GO:0006183)2.91782712
99cilium morphogenesis (GO:0060271)2.91223447
100negative regulation of DNA repair (GO:0045738)2.90970379
101positive regulation of calcium ion import (GO:0090280)2.88410378
102positive regulation of glycolytic process (GO:0045821)2.87140591
103positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.86904709
104retinal metabolic process (GO:0042574)2.85028233
105negative regulation of hormone biosynthetic process (GO:0032353)2.83431712
106regulation of protein glycosylation (GO:0060049)2.80986481
107UDP-N-acetylglucosamine metabolic process (GO:0006047)2.80800921
108retinol metabolic process (GO:0042572)2.78016472
109sphingoid metabolic process (GO:0046519)2.77489246
110protein refolding (GO:0042026)2.77442908
111regulation of spindle checkpoint (GO:0090231)2.76974628
112regulation of transforming growth factor beta1 production (GO:0032908)2.76335289
113protein targeting to lysosome (GO:0006622)2.75565186
114establishment of protein localization to vacuole (GO:0072666)2.75565186
115protein targeting to vacuole (GO:0006623)2.75565186
116signal peptide processing (GO:0006465)2.73701067
117gene silencing (GO:0016458)2.72728048
118interleukin-6-mediated signaling pathway (GO:0070102)2.72473047
119Leydig cell differentiation (GO:0033327)2.72331730
120glycolytic process (GO:0006096)2.70657777
121negative regulation of keratinocyte proliferation (GO:0010839)2.67692000
122response to redox state (GO:0051775)2.67314642
123nitric oxide mediated signal transduction (GO:0007263)2.66056601
124cellular ketone body metabolic process (GO:0046950)2.65190580
125single strand break repair (GO:0000012)2.64475749
126mitotic sister chromatid cohesion (GO:0007064)2.63910718
127sphingomyelin metabolic process (GO:0006684)2.63490528
128tachykinin receptor signaling pathway (GO:0007217)2.63108945
129bicarbonate transport (GO:0015701)2.62588832
130urinary tract smooth muscle contraction (GO:0014848)2.61554153
131basic amino acid transport (GO:0015802)2.60547419
132microtubule polymerization or depolymerization (GO:0031109)2.59265514
133UTP biosynthetic process (GO:0006228)2.58587785
134chromosome condensation (GO:0030261)2.57763334
135peptide hormone secretion (GO:0030072)2.56936793
136positive regulation of glycoprotein biosynthetic process (GO:0010560)2.56442119
137peptide secretion (GO:0002790)2.55974044
138regulation of glucokinase activity (GO:0033131)2.55905349
139regulation of hexokinase activity (GO:1903299)2.55905349
140calcium ion import (GO:0070509)2.55389810
141cytochrome complex assembly (GO:0017004)2.55288176
142nucleus organization (GO:0006997)2.55172592
143early endosome to late endosome transport (GO:0045022)2.55083651
144fatty acid transmembrane transport (GO:1902001)2.53650912
145respiratory chain complex IV assembly (GO:0008535)2.52871076
146bundle of His cell to Purkinje myocyte communication (GO:0086069)2.51857210
147peptidyl-glutamic acid modification (GO:0018200)2.50043524
148behavioral response to ethanol (GO:0048149)2.49566138
149DNA packaging (GO:0006323)2.49402426
150protein localization to vacuole (GO:0072665)2.48429575
151protein localization to lysosome (GO:0061462)2.48429575
152DNA alkylation (GO:0006305)2.47209223
153xenobiotic catabolic process (GO:0042178)2.47165180
154positive regulation of uterine smooth muscle contraction (GO:0070474)2.46777394
155endosome to pigment granule transport (GO:0043485)2.43880081
156endosome to melanosome transport (GO:0035646)2.43880081
157female gonad development (GO:0008585)2.43245021
158positive regulation of neurological system process (GO:0031646)2.42502430
159negative regulation of hormone metabolic process (GO:0032351)2.42308974
160inner ear receptor cell differentiation (GO:0060113)2.41895370
161eosinophil chemotaxis (GO:0048245)2.37792929
162regulation of calcium ion import (GO:0090279)2.37636090
163glycerophospholipid catabolic process (GO:0046475)2.36280183
164regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.33707972
165carnitine shuttle (GO:0006853)2.33652135
166dopamine transport (GO:0015872)2.33477310
167cilium or flagellum-dependent cell motility (GO:0001539)16.1457693
168fusion of sperm to egg plasma membrane (GO:0007342)14.3622634
169acrosome assembly (GO:0001675)11.9501238
170multicellular organism reproduction (GO:0032504)11.8491196
171* sperm motility (GO:0030317)11.4948616
172sperm-egg recognition (GO:0035036)11.3179737
173axonemal dynein complex assembly (GO:0070286)11.0132087
174plasma membrane fusion (GO:0045026)10.9467320
175cell wall macromolecule metabolic process (GO:0044036)10.7234652
176cell wall macromolecule catabolic process (GO:0016998)10.7234652
177piRNA metabolic process (GO:0034587)10.6324310
178binding of sperm to zona pellucida (GO:0007339)10.3242273
179epithelial cilium movement (GO:0003351)10.2298530
180cell-cell recognition (GO:0009988)10.1380980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22521131
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.18953504
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.81477402
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.42213857
5GBX2_23144817_ChIP-Seq_PC3_Human2.93141932
6IGF1R_20145208_ChIP-Seq_DFB_Human2.76962947
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.73958929
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.69099130
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.63033092
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61760052
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.61414208
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.56230036
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55515255
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.48627419
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36180552
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32683251
17FUS_26573619_Chip-Seq_HEK293_Human2.29188676
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27738107
19PIAS1_25552417_ChIP-Seq_VCAP_Human2.26948349
20ZNF217_24962896_ChIP-Seq_MCF-7_Human2.22989468
21ZNF274_21170338_ChIP-Seq_K562_Hela2.19919584
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09051308
23P300_19829295_ChIP-Seq_ESCs_Human2.07242517
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.1232169
25CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.97269524
26SMAD4_21799915_ChIP-Seq_A2780_Human1.95021599
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.89775353
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86181788
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83212450
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.82441020
31CDX2_22108803_ChIP-Seq_LS180_Human1.78630700
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.78052386
33TP53_18474530_ChIP-ChIP_U2OS_Human1.77016149
34VDR_22108803_ChIP-Seq_LS180_Human1.74575993
35KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.74514439
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.74457781
37GATA1_26923725_Chip-Seq_HPCs_Mouse1.73421410
38TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72133673
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70772447
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70449315
41KAP1_22055183_ChIP-Seq_ESCs_Mouse1.69560167
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.69495127
43STAT3_23295773_ChIP-Seq_U87_Human1.68624577
44CJUN_26792858_Chip-Seq_BT549_Human1.66568801
45TP53_16413492_ChIP-PET_HCT116_Human1.65494706
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.63856779
47AR_25329375_ChIP-Seq_VCAP_Human1.62382569
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.61494183
49AHR_22903824_ChIP-Seq_MCF-7_Human1.59472033
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59314316
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58990617
52STAT1_17558387_ChIP-Seq_HELA_Human1.58318320
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.58202798
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57378022
55GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.55075063
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53964775
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.51888224
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51773145
59WDR5_24793694_ChIP-Seq_LNCAP_Human1.51350169
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51203289
61EWS_26573619_Chip-Seq_HEK293_Human1.50146546
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48967398
63TCF4_22108803_ChIP-Seq_LS180_Human1.48752257
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48544174
65KDM2B_26808549_Chip-Seq_REH_Human1.48200216
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43166194
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43105378
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42163742
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41913455
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41885096
71CBP_20019798_ChIP-Seq_JUKART_Human1.40824491
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40824491
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40815509
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39698911
75TP63_23658742_ChIP-Seq_EP156T_Human1.38051250
76NFYB_21822215_ChIP-Seq_K562_Human1.32636336
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32366975
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31493426
79BRD4_25478319_ChIP-Seq_HGPS_Human1.30256174
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29047617
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.28405658
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.28295684
83FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28109689
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26963284
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.26397150
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26097050
87TBL1_22424771_ChIP-Seq_293T_Human1.24901965
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24163394
89PHF8_20622853_ChIP-Seq_HELA_Human1.23477581
90OCT4_18555785_Chip-Seq_ESCs_Mouse1.22968730
91SOX2_19829295_ChIP-Seq_ESCs_Human1.22109672
92NANOG_19829295_ChIP-Seq_ESCs_Human1.22109672
93GATA3_21867929_ChIP-Seq_CD8_Mouse1.21935463
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.21641224
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21579811
96SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21130344
97HNFA_21074721_ChIP-Seq_CACO-2_Human1.21060022
98RNF2_27304074_Chip-Seq_NSC_Mouse1.20903754
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.20026928
100RUNX2_22187159_ChIP-Seq_PCA_Human1.19480473
101GATA3_21867929_ChIP-Seq_TH1_Mouse1.19426185
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.19390158
103PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17487584
104LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17369360
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.17172767
106P53_22387025_ChIP-Seq_ESCs_Mouse1.17016469
107REST_21632747_ChIP-Seq_MESCs_Mouse1.16913865
108RBPJ_21746931_ChIP-Seq_IB4_Human1.16480608
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16389248
110P300_18555785_Chip-Seq_ESCs_Mouse1.15942210
111CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14899629
112ETV1_20927104_ChIP-Seq_GIST48_Human1.14374794
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13946374
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13328976
115CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12149349
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.12037056
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11878712
118SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11666702
119GATA4_25053715_ChIP-Seq_YYC3_Human1.11600711
120KLF4_18555785_Chip-Seq_ESCs_Mouse1.11400101
121SMAD3_21741376_ChIP-Seq_HESCs_Human1.10354977
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09844096
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09844096
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09485872
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09453710
126STAT3_18555785_Chip-Seq_ESCs_Mouse1.08321251
127NFYA_21822215_ChIP-Seq_K562_Human1.07288698
128ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06484587
129P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03665573
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03601723
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02685320
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02643649
133GF1_26923725_Chip-Seq_HPCs_Mouse1.02433130
134CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02349389
135FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02282946
136SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01459515
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01186364
138AR_21572438_ChIP-Seq_LNCaP_Human1.00727793
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00693684
140MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00012961
141P53_21459846_ChIP-Seq_SAOS-2_Human0.99934333
142RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99393584
143CBX2_22325352_ChIP-Seq_293T-Rex_Human0.99369199
144RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97514495
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96150974
146CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95745738
147PU1_27457419_Chip-Seq_LIVER_Mouse0.95469249
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93652449
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93627734
150SOX2_18555785_Chip-Seq_ESCs_Mouse0.92404106
151ER_23166858_ChIP-Seq_MCF-7_Human0.92273280
152EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92095127
153E2F1_18555785_Chip-Seq_ESCs_Mouse0.91808886
154CTCF_18555785_Chip-Seq_ESCs_Mouse0.91785315
155ESET_19884257_ChIP-Seq_ESCs_Mouse0.91685936
156TCF4_23295773_ChIP-Seq_U87_Human0.89960083
157ZFX_18555785_Chip-Seq_ESCs_Mouse0.89352935
158FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89303515
159RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88914085
160PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88435016
161TAF15_26573619_Chip-Seq_HEK293_Human0.88040094
162ERG_20517297_ChIP-Seq_VCAP_Human0.87844758
163PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87829992
164SMAD1_18555785_Chip-Seq_ESCs_Mouse0.87349175
165PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87001691
166EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86853706
167SOX9_26525672_Chip-Seq_HEART_Mouse0.85841623
168NMYC_18555785_Chip-Seq_ESCs_Mouse0.85265631
169BCAT_22108803_ChIP-Seq_LS180_Human0.84420443
170SPI1_26923725_Chip-Seq_HPCs_Mouse0.83921695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis8.59694059
2MP0003698_abnormal_male_reproductive6.05995371
3MP0008877_abnormal_DNA_methylation5.60745006
4MP0001929_abnormal_gametogenesis5.59824266
5MP0002210_abnormal_sex_determination3.94898764
6MP0002653_abnormal_ependyma_morphology3.49052684
7MP0001145_abnormal_male_reproductive3.30117975
8MP0002161_abnormal_fertility/fecundity3.26603960
9MP0006082_CNS_inflammation3.13158529
10MP0002163_abnormal_gland_morphology3.12646711
11MP0009780_abnormal_chondrocyte_physiolo3.11772883
12MP0000653_abnormal_sex_gland2.88012116
13MP0000013_abnormal_adipose_tissue2.73320574
14MP0005379_endocrine/exocrine_gland_phen2.72223648
15MP0002254_reproductive_system_inflammat2.71754390
16MP0002837_dystrophic_cardiac_calcinosis2.60069900
17MP0004272_abnormal_basement_membrane2.57801553
18MP0005623_abnormal_meninges_morphology2.48302806
19MP0006054_spinal_hemorrhage2.47489462
20MP0010234_abnormal_vibrissa_follicle2.28351637
21MP0008057_abnormal_DNA_replication2.13865116
22MP0010678_abnormal_skin_adnexa2.12789136
23MP0003787_abnormal_imprinting2.06325784
24MP0010386_abnormal_urinary_bladder2.04684713
25MP0001501_abnormal_sleep_pattern2.04371861
26MP0002876_abnormal_thyroid_physiology2.02294018
27MP0005410_abnormal_fertilization15.1534732
28MP0002160_abnormal_reproductive_system1.89678082
29MP0005084_abnormal_gallbladder_morpholo1.88426180
30MP0003252_abnormal_bile_duct1.69477812
31MP0005645_abnormal_hypothalamus_physiol1.67485361
32MP0003283_abnormal_digestive_organ1.65982815
33MP0002282_abnormal_trachea_morphology1.62408431
34MP0005332_abnormal_amino_acid1.55452921
35MP0008058_abnormal_DNA_repair1.53338982
36MP0000383_abnormal_hair_follicle1.52335382
37MP0001944_abnormal_pancreas_morphology1.50994218
38MP0000003_abnormal_adipose_tissue1.47639115
39MP0005670_abnormal_white_adipose1.43844844
40MP0009046_muscle_twitch1.43034859
41MP0005220_abnormal_exocrine_pancreas1.41385515
42MP0002693_abnormal_pancreas_physiology1.34312005
43MP0005646_abnormal_pituitary_gland1.33437862
44MP0005647_abnormal_sex_gland1.32911598
45MP0005085_abnormal_gallbladder_physiolo1.31782119
46MP0002909_abnormal_adrenal_gland1.29819793
47MP0005174_abnormal_tail_pigmentation1.28963396
48MP0010094_abnormal_chromosome_stability1.25393189
49MP0000015_abnormal_ear_pigmentation1.21844815
50MP0003718_maternal_effect1.16056389
51MP0001348_abnormal_lacrimal_gland1.14343027
52MP0004215_abnormal_myocardial_fiber1.14253469
53MP0002168_other_aberrant_phenotype1.13532474
54MP0003646_muscle_fatigue1.13279745
55MP0005310_abnormal_salivary_gland1.11253007
56MP0001756_abnormal_urination1.09311810
57MP0003011_delayed_dark_adaptation1.07947072
58MP0005395_other_phenotype1.06866041
59MP0002332_abnormal_exercise_endurance1.03108406
60MP0001765_abnormal_ion_homeostasis1.02050470
61MP0010329_abnormal_lipoprotein_level1.01777960
62MP0004085_abnormal_heartbeat1.01162699
63MP0004233_abnormal_muscle_weight1.00218623
64MP0008995_early_reproductive_senescence0.99180740
65MP0005389_reproductive_system_phenotype0.98475858
66MP0002138_abnormal_hepatobiliary_system0.98335948
67MP0008007_abnormal_cellular_replicative0.97300279
68MP0001666_abnormal_nutrient_absorption0.96926082
69MP0001984_abnormal_olfaction0.96086112
70MP0003786_premature_aging0.95233722
71MP0005164_abnormal_response_to0.95087922
72MP0005365_abnormal_bile_salt0.93501204
73MP0002734_abnormal_mechanical_nocicepti0.93114826
74MP0000230_abnormal_systemic_arterial0.92477887
75MP0000470_abnormal_stomach_morphology0.87694176
76MP0003950_abnormal_plasma_membrane0.85070447
77MP0000639_abnormal_adrenal_gland0.81667002
78MP0003136_yellow_coat_color0.80963356
79MP0002295_abnormal_pulmonary_circulatio0.80941241
80MP0002078_abnormal_glucose_homeostasis0.80744308
81MP0002972_abnormal_cardiac_muscle0.79426237
82MP0008872_abnormal_physiological_respon0.74966512
83MP0004134_abnormal_chest_morphology0.74866436
84MP0002938_white_spotting0.73478881
85MP0001485_abnormal_pinna_reflex0.71743227
86MP0003953_abnormal_hormone_level0.69983899
87MP0002090_abnormal_vision0.69479924
88MP0001873_stomach_inflammation0.68243515
89MP0008775_abnormal_heart_ventricle0.68063463
90MP0002118_abnormal_lipid_homeostasis0.66948869
91MP0005620_abnormal_muscle_contractility0.66434333
92MP0000631_abnormal_neuroendocrine_gland0.66237775
93MP0009643_abnormal_urine_homeostasis0.65595470
94MP0003941_abnormal_skin_development0.64702084
95MP0005075_abnormal_melanosome_morpholog0.64500930
96MP0003868_abnormal_feces_composition0.63026904
97MP0000358_abnormal_cell_content/0.61136947
98MP0000569_abnormal_digit_pigmentation0.61017943
99MP0004883_abnormal_blood_vessel0.60209835
100MP0005376_homeostasis/metabolism_phenot0.58114753
101MP0002136_abnormal_kidney_physiology0.57639430
102MP0004808_abnormal_hematopoietic_stem0.56913778
103MP0002928_abnormal_bile_duct0.56284882
104MP0001664_abnormal_digestion0.56218074
105MP0009745_abnormal_behavioral_response0.55625153
106MP0010307_abnormal_tumor_latency0.54196135
107MP0001545_abnormal_hematopoietic_system0.53778347
108MP0005397_hematopoietic_system_phenotyp0.53778347
109MP0005266_abnormal_metabolism0.52312597
110MP0003878_abnormal_ear_physiology0.51528934
111MP0005377_hearing/vestibular/ear_phenot0.51528934
112MP0003699_abnormal_female_reproductive0.50775824
113MP0005636_abnormal_mineral_homeostasis0.50745011
114MP0001119_abnormal_female_reproductive0.48477205
115MP0004019_abnormal_vitamin_homeostasis0.48407431
116MP0002234_abnormal_pharynx_morphology0.45238197
117MP0003115_abnormal_respiratory_system0.44973834
118MP0005551_abnormal_eye_electrophysiolog0.43909694
119MP0003111_abnormal_nucleus_morphology0.43407568
120MP0005253_abnormal_eye_physiology0.42868114
121MP0001324_abnormal_eye_pigmentation0.42156365
122MP0002102_abnormal_ear_morphology0.41430046
123MP0003329_amyloid_beta_deposits0.39012340
124MP0004133_heterotaxia0.37869090
125MP0001293_anophthalmia0.37746072
126MP0001851_eye_inflammation0.37221700
127MP0009278_abnormal_bone_marrow0.37118991
128MP0000427_abnormal_hair_cycle0.35659808
129MP0004036_abnormal_muscle_relaxation0.35260619
130MP0005391_vision/eye_phenotype0.33489317
131MP0005666_abnormal_adipose_tissue0.33195673
132MP0002971_abnormal_brown_adipose0.32150654
133MP0001730_embryonic_growth_arrest0.31181935
134MP0000313_abnormal_cell_death0.29287965
135MP0001727_abnormal_embryo_implantation0.28876524
136MP0003633_abnormal_nervous_system0.28470975
137MP0003077_abnormal_cell_cycle0.27077749
138MP0001764_abnormal_homeostasis0.24196744
139MP0002269_muscular_atrophy0.24160623
140MP0002405_respiratory_system_inflammati0.23378276
141MP0006036_abnormal_mitochondrial_physio0.22378991
142MP0003861_abnormal_nervous_system0.22080946
143MP0003045_fibrosis0.21902300
144MP0002152_abnormal_brain_morphology0.21775204
145MP0003631_nervous_system_phenotype0.21036912
146MP0000647_abnormal_sebaceous_gland0.20825593
147MP0006072_abnormal_retinal_apoptosis0.20676091
148MP0001986_abnormal_taste_sensitivity0.20483632
149MP0000604_amyloidosis0.20034130
150MP0009115_abnormal_fat_cell0.19658545
151MP0004811_abnormal_neuron_physiology0.18573595
152MP0002139_abnormal_hepatobiliary_system0.18570388
153MP0002084_abnormal_developmental_patter0.18057460
154MP0005388_respiratory_system_phenotype0.16723390
155MP0002133_abnormal_respiratory_system0.16723390
156MP0002092_abnormal_eye_morphology0.16488593
157MP0006138_congestive_heart_failure0.15155284
158MP0000432_abnormal_head_morphology0.15113915
159MP0005503_abnormal_tendon_morphology0.14923738
160MP0002229_neurodegeneration0.14823770
161MP0002108_abnormal_muscle_morphology0.14610231
162MP0005195_abnormal_posterior_eye0.13338506
163MP0002233_abnormal_nose_morphology0.11341751
164MP0003879_abnormal_hair_cell0.11327020
165MP0001919_abnormal_reproductive_system0.10866524
166MP0002169_no_abnormal_phenotype0.10615413
167MP0002132_abnormal_respiratory_system0.10587372
168MP0002873_normal_phenotype0.10405967
169MP0001661_extended_life_span0.10198905
170MP0000001_mammalian_phenotype0.09697720
171MP0003936_abnormal_reproductive_system0.09577746
172MP0002970_abnormal_white_adipose0.09378327
173MP0004043_abnormal_pH_regulation0.08239129

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.63145297
2Abnormal respiratory motile cilium morphology (HP:0005938)8.94731024
3Abnormal respiratory epithelium morphology (HP:0012253)8.94731024
4Rhinitis (HP:0012384)8.04976042
5Abnormal ciliary motility (HP:0012262)7.99178660
6Chronic bronchitis (HP:0004469)7.40239394
7Nasal polyposis (HP:0100582)6.43396953
8Infertility (HP:0000789)6.05051082
9Hyperkalemia (HP:0002153)5.73480295
10Abnormality of the nasal mucosa (HP:0000433)5.28477017
11Bronchiectasis (HP:0002110)4.65020235
12Bronchitis (HP:0012387)4.54566953
13Nephronophthisis (HP:0000090)4.47500180
14Recurrent sinusitis (HP:0011108)3.67937811
15Abnormality of the lower motor neuron (HP:0002366)3.55721563
16Sensory axonal neuropathy (HP:0003390)3.51379894
17Pancreatic cysts (HP:0001737)3.49529153
18Abnormality of the renal medulla (HP:0100957)3.44119254
19Hyperglycemia (HP:0003074)3.37448052
20Recurrent otitis media (HP:0000403)3.34098344
21Hypothermia (HP:0002045)3.25087499
22Male infertility (HP:0003251)3.04608916
23Tubulointerstitial nephritis (HP:0001970)2.97813771
24Febrile seizures (HP:0002373)2.86905855
25Gonadotropin excess (HP:0000837)2.81923523
26Amyotrophic lateral sclerosis (HP:0007354)2.79524016
27Menstrual irregularities (HP:0000858)2.76218477
28Abnormal spermatogenesis (HP:0008669)2.75974353
29Abnormality of potassium homeostasis (HP:0011042)2.75611275
30Medial flaring of the eyebrow (HP:0010747)2.73765232
31Abnormality of proline metabolism (HP:0010907)2.72478844
32Hydroxyprolinuria (HP:0003080)2.72478844
33Hemiparesis (HP:0001269)2.69233762
34Abnormal pancreas size (HP:0012094)2.69217920
35Hyponatremia (HP:0002902)2.66335628
36Recurrent bronchitis (HP:0002837)2.64118659
37Abnormality of midbrain morphology (HP:0002418)2.62985899
38Molar tooth sign on MRI (HP:0002419)2.62985899
39Chronic hepatic failure (HP:0100626)2.62639956
40Fibular hypoplasia (HP:0003038)2.62217815
41Gaze-evoked nystagmus (HP:0000640)2.58840848
42Proximal tubulopathy (HP:0000114)2.55982285
43Tongue fasciculations (HP:0001308)2.52206591
44Hypoglycemic seizures (HP:0002173)2.50278271
45Abnormality of macular pigmentation (HP:0008002)2.48147572
46Fair hair (HP:0002286)2.46514411
47Tubular atrophy (HP:0000092)2.46250422
48Severe visual impairment (HP:0001141)2.46034256
49Increased CSF protein (HP:0002922)2.42563514
50Type I transferrin isoform profile (HP:0003642)2.40588661
51Tubulointerstitial abnormality (HP:0001969)2.40331680
52Cone-rod dystrophy (HP:0000548)2.36881909
53Intrahepatic cholestasis (HP:0001406)2.36485441
54Abnormal albumin level (HP:0012116)2.33522401
55Hypoalbuminemia (HP:0003073)2.33522401
56Hyperinsulinemic hypoglycemia (HP:0000825)2.28741133
57Abnormal biliary tract morphology (HP:0012440)2.28298353
58Attenuation of retinal blood vessels (HP:0007843)2.27497992
59Pheochromocytoma (HP:0002666)2.26229292
60Abnormality of vitamin B metabolism (HP:0004340)2.26171392
61Absent speech (HP:0001344)2.25576000
62Albinism (HP:0001022)2.25144041
63Exocrine pancreatic insufficiency (HP:0001738)2.23473992
64Biliary tract neoplasm (HP:0100574)2.22074653
65Late onset (HP:0003584)2.19926460
66Postaxial foot polydactyly (HP:0001830)2.17323846
67Azoospermia (HP:0000027)2.16965969
68Neuroendocrine neoplasm (HP:0100634)2.13504689
69Sex reversal (HP:0012245)2.13035863
70Abnormal sex determination (HP:0012244)2.13035863
71Bony spicule pigmentary retinopathy (HP:0007737)2.12884520
72Upper motor neuron abnormality (HP:0002127)2.12491684
73Abnormality of sodium homeostasis (HP:0010931)2.12209498
74Impaired proprioception (HP:0010831)2.11137532
75Right ventricular cardiomyopathy (HP:0011663)2.05969592
76Aplasia/hypoplasia of the uterus (HP:0008684)2.04819776
77Palpitations (HP:0001962)2.03152359
78Muscle fibrillation (HP:0010546)2.02255130
79Vascular calcification (HP:0004934)2.01850182
80Stage 5 chronic kidney disease (HP:0003774)2.00891437
81Absent frontal sinuses (HP:0002688)2.00850064
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.9153833
83Dynein arm defect of respiratory motile cilia (HP:0012255)12.8410689
84Absent/shortened dynein arms (HP:0200106)12.8410689
85Stenosis of the external auditory canal (HP:0000402)1.98985023
86Hypoglycemic coma (HP:0001325)1.97654324
87Impulsivity (HP:0100710)1.96961484
88Degeneration of anterior horn cells (HP:0002398)1.94971839
89Abnormality of the anterior horn cell (HP:0006802)1.94971839
90Bundle branch block (HP:0011710)1.93846976
91Neonatal hypoglycemia (HP:0001998)1.93646325
92Constricted visual fields (HP:0001133)1.93224830
93Generalized hypopigmentation of hair (HP:0011358)1.92812845
94Microglossia (HP:0000171)1.92732268
95Congenital hepatic fibrosis (HP:0002612)1.92394835
96Congenital sensorineural hearing impairment (HP:0008527)1.91700273
97Unilateral renal agenesis (HP:0000122)1.89916122
98Polar cataract (HP:0010696)1.89704394
99J-shaped sella turcica (HP:0002680)1.88388342
100Abnormality of the renal cortex (HP:0011035)1.88108838
101Chronic sinusitis (HP:0011109)1.87795185
102Abnormality of endocrine pancreas physiology (HP:0012093)1.87586918
103Abnormality of the pancreatic islet cells (HP:0006476)1.87586918
104Steatorrhea (HP:0002570)1.87170439
105Metaphyseal dysplasia (HP:0100255)1.86697840
106Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86652818
107Hypokinesia (HP:0002375)1.86416529
108Lip pit (HP:0100267)1.84620446
109Hamartoma of the eye (HP:0010568)1.82574998
110Tubulointerstitial fibrosis (HP:0005576)1.82307365
111Insulin-resistant diabetes mellitus (HP:0000831)1.81890942
112Abnormality of the dental root (HP:0006486)1.81658679
113Taurodontia (HP:0000679)1.81658679
114Abnormality of permanent molar morphology (HP:0011071)1.81658679
115Hypomagnesemia (HP:0002917)1.81252433
116Mitral stenosis (HP:0001718)1.80976921
117Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80886472
118Abnormal protein N-linked glycosylation (HP:0012347)1.80886472
119Abnormal protein glycosylation (HP:0012346)1.80886472
120Abnormal glycosylation (HP:0012345)1.80886472
121Symptomatic seizures (HP:0011145)1.80023828
122Ketoacidosis (HP:0001993)1.79832523
123Short ribs (HP:0000773)1.79428898
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.78564962
125Chorioretinal atrophy (HP:0000533)1.78419764
126Nuclear cataract (HP:0100018)1.78402107
127Abnormality of vitamin metabolism (HP:0100508)1.78226339
128Renal cortical cysts (HP:0000803)1.77979659
129Supernumerary spleens (HP:0009799)1.74460515
130Oculomotor apraxia (HP:0000657)1.74390216
131Abnormality of molar morphology (HP:0011070)1.71044605
132Abnormality of molar (HP:0011077)1.71044605
133Renal dysplasia (HP:0000110)1.71014253
134Abnormality of dentin (HP:0010299)1.70469085
13511 pairs of ribs (HP:0000878)1.70269064
136Abnormal drinking behavior (HP:0030082)1.69119623
137Polydipsia (HP:0001959)1.69119623
138Congenital primary aphakia (HP:0007707)1.65461635
139Gait imbalance (HP:0002141)1.65274271
140Abnormality of the dental pulp (HP:0006479)1.65074727
141Aplasia/Hypoplasia of the fibula (HP:0006492)1.64878101
142Facial cleft (HP:0002006)1.64610966
143Postaxial hand polydactyly (HP:0001162)1.63880795
144Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.60384430
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.59609599
146Spastic tetraparesis (HP:0001285)1.56352931
147Pancreatic fibrosis (HP:0100732)1.54070873
148Abnormality of renal excretion (HP:0011036)1.53186972
149Median cleft lip (HP:0000161)1.52605479
150Cystic liver disease (HP:0006706)1.48782974
151Breast carcinoma (HP:0003002)1.47661786
152Absent epiphyses (HP:0010577)1.46316705
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.46316705
154Nephrogenic diabetes insipidus (HP:0009806)1.41238869
155Bell-shaped thorax (HP:0001591)1.41052926
156Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.40895750
157Heterotopia (HP:0002282)1.40276847
158Deformed sella turcica (HP:0002681)1.38971797
159Conjunctival telangiectasia (HP:0000524)1.37992508
160Short thorax (HP:0010306)1.37981797
161Bile duct proliferation (HP:0001408)1.37380648
162Abnormal biliary tract physiology (HP:0012439)1.37380648
163True hermaphroditism (HP:0010459)1.34336408
164Abnormality of ocular smooth pursuit (HP:0000617)1.33823247
165Large eyes (HP:0001090)1.30501307
166Selective tooth agenesis (HP:0001592)1.29721374
167Nephropathy (HP:0000112)1.29317166
168Hypoplasia of dental enamel (HP:0006297)1.29226866
169Poor coordination (HP:0002370)1.26608256
170Abnormal gallbladder physiology (HP:0012438)1.26309723
171Cholecystitis (HP:0001082)1.26309723
172Aplasia/Hypoplasia of the lens (HP:0008063)1.25727679
173Broad distal phalanx of finger (HP:0009836)1.25697794
174Genital tract atresia (HP:0001827)1.25007842
175Pachygyria (HP:0001302)1.23501530
176Dyschromatopsia (HP:0007641)1.23412336
177Vaginal atresia (HP:0000148)1.23107060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.66357196
2PDK49.66357196
3PDK26.34500998
4CASK4.17531890
5TNIK4.01487336
6TESK13.47355690
7MST43.44843228
8MST1R3.16745321
9BCR2.99739258
10PRKD32.89992735
11ICK2.42285453
12WNK42.38612747
13STK392.38606135
14PNCK2.37755614
15PTK2B2.32929932
16PLK22.09283106
17ACVR1B1.89862898
18GRK11.87500599
19EIF2AK31.78089894
20MYLK1.71288369
21TRIM281.69290587
22ADRBK21.66862426
23NEK21.66336599
24BRD41.61175493
25INSRR1.58764623
26MAP3K121.57452141
27PAK31.55246152
28STK241.52744251
29MET1.46088822
30FER1.36189849
31MKNK21.36108026
32PRKCE1.29734212
33DAPK21.21305604
34TRPM71.15813150
35PIK3CG1.14602977
36FGFR21.11328604
37WNK11.07477301
38STK381.04201560
39CDK80.99024249
40EPHA20.98711388
41AKT30.97391110
42ADRBK10.96622992
43MAPK150.95021334
44PHKG20.88202330
45PHKG10.88202330
46MAP3K20.87859752
47CCNB10.87699096
48PDK10.87146954
49CDC70.85768459
50STK30.85744287
51TYRO30.85495011
52ERBB30.84190413
53OXSR10.79741976
54PASK0.79082035
55NLK0.78979639
56NUAK10.77322085
57NTRK30.75683679
58DYRK1B0.75104434
59PTK20.71431101
60LMTK20.69568370
61WEE10.68812069
62PRKCI0.68074895
63PIK3CA0.67375293
64OBSCN0.66057712
65IRAK30.65676590
66IRAK10.63698309
67TEC0.63409745
68TTK0.61795229
69DYRK30.59899506
70ERBB40.53281881
71PLK40.51416257
72BMPR1B0.51128074
73PLK30.50406950
74CHEK10.50166536
75ATR0.49754573
76CHEK20.46969105
77PINK10.46873799
78MAP2K10.45849576
79CSNK1G10.45653472
80CAMK1G0.44776363
81MAP3K70.43946756
82TGFBR10.42192448
83LATS10.41625626
84ABL20.40912438
85CAMK2D0.40214494
86CSNK1G20.39979951
87CDK120.39377309
88ROCK10.38981407
89TIE10.36701171
90PRKAA20.36471195
91ATM0.35385029
92MAP2K60.34454130
93GSK3A0.34223017
94EIF2AK10.34128848
95BMX0.34056931
96DAPK30.31848594
97MAP4K20.31186009
98DAPK10.30953521
99STK38L0.30567723
100TESK20.30459811
101FGFR10.30029001
102SGK20.27365534
103IKBKB0.27031739
104PLK10.24857338
105MUSK0.23778022
106NEK10.23589054
107MTOR0.23546913
108PAK10.23531398
109PDPK10.23165270
110ABL10.22027096
111AKT20.21570662
112PAK20.21187324
113NTRK20.20947202
114CSNK1G30.20324692
115RIPK40.17430042
116PRKCG0.16547773
117CAMKK10.16270736
118MAPKAPK50.16186301
119RPS6KB10.15621095
120NEK60.15616953
121IRAK20.14344197
122PRKAA10.14028219
123EEF2K0.13770252
124MAP3K40.13581675
125BRSK20.12355276
126MAP2K70.11671114
127WNK30.09856609
128CSNK1D0.09487917
129MARK20.07921500
130PRKG10.07458472
131CDK10.05994012
132PRKACG0.05915831
133PRKCQ0.05733219
134CSNK2A10.05518628
135MARK30.05392860
136PRKACB0.04862355
137PRKDC0.04582862
138STK100.04271686
139YES10.03939098
140CDK20.03751145
141ZAP700.03571246
142MAPK80.03222044
143PDGFRB0.02865220
144GSK3B0.02848937
145BRAF0.02410180
146CDK150.02040574
147CSNK2A20.01778289
148PRKCZ0.01741758
149EGFR0.01554941
150PKN10.01031111
151PRKG20.00445459
152CSK0.00301938
153CDK180.00071888
154BRSK1-0.0348256
155MAPK1-0.0310621
156PRKACA-0.0304965
157PRKCA-0.0276428
158FRK-0.0265968
159CAMK2A-0.0251314
160STK11-0.0250491
161RPS6KA1-0.0210401
162CDK14-0.0206666
163PRKCB-0.0153516
164PAK6-0.0134142
165RPS6KA3-0.0090440
166MAPK10-0.0060816
167CDK11A-0.0051491
168CSF1R-0.0026719
169CDK3-0.0026213

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.36031066
2Nitrogen metabolism_Homo sapiens_hsa009105.21050234
3Pyruvate metabolism_Homo sapiens_hsa006204.56123902
4Maturity onset diabetes of the young_Homo sapiens_hsa049504.55255318
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.21592740
6Propanoate metabolism_Homo sapiens_hsa006403.66669426
7Glucagon signaling pathway_Homo sapiens_hsa049222.89625270
8Basal transcription factors_Homo sapiens_hsa030222.87433513
9Pentose phosphate pathway_Homo sapiens_hsa000302.86899652
10Fatty acid biosynthesis_Homo sapiens_hsa000612.77312786
11Selenocompound metabolism_Homo sapiens_hsa004502.65309356
12Dorso-ventral axis formation_Homo sapiens_hsa043202.60990011
13Fanconi anemia pathway_Homo sapiens_hsa034602.57915009
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29068550
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.25261390
16Sulfur metabolism_Homo sapiens_hsa009202.21534153
17Linoleic acid metabolism_Homo sapiens_hsa005912.20318699
18Circadian rhythm_Homo sapiens_hsa047102.20017927
19Oocyte meiosis_Homo sapiens_hsa041142.12131316
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11189374
21Huntingtons disease_Homo sapiens_hsa050162.06046921
22Sphingolipid metabolism_Homo sapiens_hsa006002.06007277
23Protein export_Homo sapiens_hsa030601.94554311
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.89219657
25Glycerolipid metabolism_Homo sapiens_hsa005611.86610457
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.84974935
27Butanoate metabolism_Homo sapiens_hsa006501.81298388
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.72543770
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.64830551
30Phototransduction_Homo sapiens_hsa047441.60815083
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55589236
32PPAR signaling pathway_Homo sapiens_hsa033201.53786437
33Carbon metabolism_Homo sapiens_hsa012001.48690329
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.46099411
35Amphetamine addiction_Homo sapiens_hsa050311.45973758
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.37857014
37Renin secretion_Homo sapiens_hsa049241.37090334
38African trypanosomiasis_Homo sapiens_hsa051431.32312046
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31536740
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28650790
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27476065
42Fructose and mannose metabolism_Homo sapiens_hsa000511.23802000
43mRNA surveillance pathway_Homo sapiens_hsa030151.23556315
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21271539
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17778715
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15746237
47RNA transport_Homo sapiens_hsa030131.15652170
48ECM-receptor interaction_Homo sapiens_hsa045121.15274226
49Cardiac muscle contraction_Homo sapiens_hsa042601.15058994
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.10543489
51Starch and sucrose metabolism_Homo sapiens_hsa005001.07617587
52Serotonergic synapse_Homo sapiens_hsa047261.07009287
53Antigen processing and presentation_Homo sapiens_hsa046121.04868463
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04797208
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04176683
56Biosynthesis of amino acids_Homo sapiens_hsa012301.04115719
57Non-homologous end-joining_Homo sapiens_hsa034501.01281172
58Olfactory transduction_Homo sapiens_hsa047401.01180671
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99646290
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99590136
61Purine metabolism_Homo sapiens_hsa002300.97714970
62Ether lipid metabolism_Homo sapiens_hsa005650.97112983
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94928933
64Tryptophan metabolism_Homo sapiens_hsa003800.94759465
65Tight junction_Homo sapiens_hsa045300.92388681
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92105992
67Mineral absorption_Homo sapiens_hsa049780.88789328
68Fat digestion and absorption_Homo sapiens_hsa049750.88175592
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83817587
70ABC transporters_Homo sapiens_hsa020100.81698169
71Long-term potentiation_Homo sapiens_hsa047200.81327772
72Fatty acid elongation_Homo sapiens_hsa000620.79127897
73Fatty acid metabolism_Homo sapiens_hsa012120.78835288
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78716688
75GABAergic synapse_Homo sapiens_hsa047270.74571530
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73788404
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73493908
78Regulation of autophagy_Homo sapiens_hsa041400.73464531
79Fatty acid degradation_Homo sapiens_hsa000710.72690046
80Long-term depression_Homo sapiens_hsa047300.72134934
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71068247
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69308997
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68065164
84Adherens junction_Homo sapiens_hsa045200.64767653
85Calcium signaling pathway_Homo sapiens_hsa040200.63279264
86Glutathione metabolism_Homo sapiens_hsa004800.61416397
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61303191
88Dopaminergic synapse_Homo sapiens_hsa047280.60754732
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.58998885
90Dilated cardiomyopathy_Homo sapiens_hsa054140.58614874
91Chemical carcinogenesis_Homo sapiens_hsa052040.57666795
92Peroxisome_Homo sapiens_hsa041460.57397787
93Estrogen signaling pathway_Homo sapiens_hsa049150.55836653
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55693295
95N-Glycan biosynthesis_Homo sapiens_hsa005100.55641049
96Legionellosis_Homo sapiens_hsa051340.54366793
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51998268
98VEGF signaling pathway_Homo sapiens_hsa043700.51136078
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50311020
100Arachidonic acid metabolism_Homo sapiens_hsa005900.50003811
101Collecting duct acid secretion_Homo sapiens_hsa049660.49708273
102Renin-angiotensin system_Homo sapiens_hsa046140.49703030
103Caffeine metabolism_Homo sapiens_hsa002320.49405955
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49382204
105Inositol phosphate metabolism_Homo sapiens_hsa005620.49016747
106Type I diabetes mellitus_Homo sapiens_hsa049400.48738035
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48374572
108Oxidative phosphorylation_Homo sapiens_hsa001900.48323230
109p53 signaling pathway_Homo sapiens_hsa041150.47771190
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46428078
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45488162
112Cocaine addiction_Homo sapiens_hsa050300.45441774
113Type II diabetes mellitus_Homo sapiens_hsa049300.44641397
114Insulin resistance_Homo sapiens_hsa049310.43566882
115Homologous recombination_Homo sapiens_hsa034400.43288636
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43263133
117Morphine addiction_Homo sapiens_hsa050320.42396867
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39315205
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37940365
120Metabolic pathways_Homo sapiens_hsa011000.37475552
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.37367679
122Vitamin digestion and absorption_Homo sapiens_hsa049770.37272558
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35990309
124Endocytosis_Homo sapiens_hsa041440.34488703
125AMPK signaling pathway_Homo sapiens_hsa041520.33492450
126Hedgehog signaling pathway_Homo sapiens_hsa043400.33137782
127Taste transduction_Homo sapiens_hsa047420.32982410
128Systemic lupus erythematosus_Homo sapiens_hsa053220.31434035
129RNA degradation_Homo sapiens_hsa030180.30937512
130B cell receptor signaling pathway_Homo sapiens_hsa046620.30935666
131Cell cycle_Homo sapiens_hsa041100.30827821
132Thyroid hormone synthesis_Homo sapiens_hsa049180.29901238
133Insulin secretion_Homo sapiens_hsa049110.29867616
134Bile secretion_Homo sapiens_hsa049760.27436220
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26988772
136Protein digestion and absorption_Homo sapiens_hsa049740.25762890
137Salmonella infection_Homo sapiens_hsa051320.24297302
138Circadian entrainment_Homo sapiens_hsa047130.22075564
139Pancreatic secretion_Homo sapiens_hsa049720.21052681
140Retinol metabolism_Homo sapiens_hsa008300.19499876
141Synaptic vesicle cycle_Homo sapiens_hsa047210.17951168
142Wnt signaling pathway_Homo sapiens_hsa043100.17268283
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.16613699
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16550786
145Viral carcinogenesis_Homo sapiens_hsa052030.15664175
146Pyrimidine metabolism_Homo sapiens_hsa002400.14880662
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.14747378
148cAMP signaling pathway_Homo sapiens_hsa040240.14696884
149Glutamatergic synapse_Homo sapiens_hsa047240.12416240
150Salivary secretion_Homo sapiens_hsa049700.11785459
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10951816
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.10694545
153Gastric acid secretion_Homo sapiens_hsa049710.08769274

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