SLC9A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of gastrointestinal epithelium (GO:0030277)7.64184756
2oligosaccharide biosynthetic process (GO:0009312)7.03518829
3behavioral response to nicotine (GO:0035095)6.44389873
4O-glycan processing (GO:0016266)6.05968767
5epithelial structure maintenance (GO:0010669)5.78180693
6regulation of proton transport (GO:0010155)5.47374017
7indole-containing compound catabolic process (GO:0042436)4.55171295
8indolalkylamine catabolic process (GO:0046218)4.55171295
9tryptophan catabolic process (GO:0006569)4.55171295
10kynurenine metabolic process (GO:0070189)4.54843192
11thioester biosynthetic process (GO:0035384)4.51321213
12acyl-CoA biosynthetic process (GO:0071616)4.51321213
13digestion (GO:0007586)4.45675590
14fatty-acyl-CoA biosynthetic process (GO:0046949)4.35231773
15regulation of sequestering of triglyceride (GO:0010889)4.26618240
16carnitine shuttle (GO:0006853)4.22235523
17extracellular fibril organization (GO:0043206)4.19354916
18long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.18761159
19indolalkylamine metabolic process (GO:0006586)4.16925533
20alpha-linolenic acid metabolic process (GO:0036109)4.09078286
21protein O-linked glycosylation (GO:0006493)4.04314004
22fatty acid transmembrane transport (GO:1902001)4.04222073
23L-fucose catabolic process (GO:0042355)3.99693885
24fucose catabolic process (GO:0019317)3.99693885
25L-fucose metabolic process (GO:0042354)3.99693885
26regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.94837811
27positive regulation of macrophage cytokine production (GO:0060907)3.91131341
28positive regulation by symbiont of host defense response (GO:0052509)3.86460072
29modulation by symbiont of host defense response (GO:0052031)3.86460072
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.86460072
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.86460072
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.86460072
33modulation by symbiont of host immune response (GO:0052553)3.86460072
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86382608
35regulation of phospholipase A2 activity (GO:0032429)3.82995126
36neuronal action potential (GO:0019228)3.82355865
37positive regulation of p38MAPK cascade (GO:1900745)3.73363470
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.73239458
39tryptophan metabolic process (GO:0006568)3.71538945
40fibril organization (GO:0097435)3.69478963
41arachidonic acid secretion (GO:0050482)3.68680145
42icosanoid secretion (GO:0032309)3.68680145
43primary amino compound metabolic process (GO:1901160)3.68652338
44long-chain fatty acid transport (GO:0015909)3.66694510
45cilium or flagellum-dependent cell motility (GO:0001539)3.66462760
46pyrimidine-containing compound transmembrane transport (GO:0072531)3.65203173
47mammary gland epithelial cell differentiation (GO:0060644)3.65140772
48serotonin metabolic process (GO:0042428)3.62348937
49indole-containing compound metabolic process (GO:0042430)3.59061802
50* digestive system process (GO:0022600)3.57871523
51positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.56608019
52detection of light stimulus involved in visual perception (GO:0050908)3.49556719
53detection of light stimulus involved in sensory perception (GO:0050962)3.49556719
54regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.44964220
55linoleic acid metabolic process (GO:0043651)3.44355084
56regulation of action potential (GO:0098900)3.42002932
57biotin metabolic process (GO:0006768)3.39551677
58icosanoid transport (GO:0071715)3.35541188
59fatty acid derivative transport (GO:1901571)3.35541188
60positive regulation of action potential (GO:0045760)3.33514417
61glutathione derivative metabolic process (GO:1901685)3.32887980
62glutathione derivative biosynthetic process (GO:1901687)3.32887980
63response to pheromone (GO:0019236)3.32644712
64regulation of clathrin-mediated endocytosis (GO:2000369)3.31786035
65cellular ketone body metabolic process (GO:0046950)3.31021297
66gamma-aminobutyric acid transport (GO:0015812)3.30577005
67behavioral response to ethanol (GO:0048149)3.28186903
68long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.27465874
69fatty acid transport (GO:0015908)3.23623083
70macrophage activation involved in immune response (GO:0002281)3.22109067
71ectoderm development (GO:0007398)3.21749770
72negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18489984
73response to iron ion (GO:0010039)3.18272769
74reflex (GO:0060004)3.17779868
75fatty-acyl-CoA metabolic process (GO:0035337)3.17668311
76energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.16512848
77ATP hydrolysis coupled proton transport (GO:0015991)3.16512848
78cellular biogenic amine catabolic process (GO:0042402)3.16280258
79amine catabolic process (GO:0009310)3.16280258
80DNA deamination (GO:0045006)3.15939582
81thyroid hormone metabolic process (GO:0042403)3.15558418
82pattern specification involved in kidney development (GO:0061004)3.14962081
83triglyceride biosynthetic process (GO:0019432)3.14726793
84positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.13212985
85apoptotic cell clearance (GO:0043277)3.12984886
86regulation of interferon-beta biosynthetic process (GO:0045357)3.12819174
87epithelial cilium movement (GO:0003351)3.12543004
88pH reduction (GO:0045851)3.10661350
89cornea development in camera-type eye (GO:0061303)3.09791114
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08155374
91negative regulation of mast cell activation (GO:0033004)3.07970734
92carnitine transmembrane transport (GO:1902603)3.06754599
93regulation of macrophage cytokine production (GO:0010935)3.04037877
94acylglycerol biosynthetic process (GO:0046463)3.03787765
95neutral lipid biosynthetic process (GO:0046460)3.03787765
96negative regulation of telomere maintenance (GO:0032205)3.03543866
97neutrophil mediated immunity (GO:0002446)3.01805261
98neural tube formation (GO:0001841)3.01593586
99regulation of early endosome to late endosome transport (GO:2000641)3.00715954
100ketone body metabolic process (GO:1902224)3.00029327
101rRNA catabolic process (GO:0016075)2.98572750
102regulation of p38MAPK cascade (GO:1900744)2.97309007
103intracellular lipid transport (GO:0032365)2.97010636
104cellular response to ATP (GO:0071318)2.96401494
105pyrimidine nucleobase catabolic process (GO:0006208)2.96391256
106lactation (GO:0007595)2.94217915
107protein localization to endosome (GO:0036010)2.93515177
108N-acetylneuraminate metabolic process (GO:0006054)2.92564630
109platelet dense granule organization (GO:0060155)2.92112039
110synaptic transmission, cholinergic (GO:0007271)2.90331289
111leukotriene metabolic process (GO:0006691)2.89974916
112piRNA metabolic process (GO:0034587)2.88481002
113microglial cell activation (GO:0001774)2.87649744
114nephron tubule morphogenesis (GO:0072078)2.86788055
115nephron epithelium morphogenesis (GO:0072088)2.86788055
116startle response (GO:0001964)2.86407979
117carnitine transport (GO:0015879)2.86057713
118amino-acid betaine transport (GO:0015838)2.86057713
119secretion by tissue (GO:0032941)2.85662215
120nonmotile primary cilium assembly (GO:0035058)2.85577535
121response to host (GO:0075136)2.84916822
122response to host defenses (GO:0052200)2.84916822
123response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.84916822
124leukotriene biosynthetic process (GO:0019370)2.83935802
125membrane depolarization during action potential (GO:0086010)2.83475212
126sodium ion export (GO:0071436)2.82226130
127response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78723919
128response to host immune response (GO:0052572)2.78723919
129axoneme assembly (GO:0035082)2.78579457
130thyroid hormone generation (GO:0006590)2.78575787
131protein polyglutamylation (GO:0018095)2.78142327
132parturition (GO:0007567)2.77802710
133sulfation (GO:0051923)2.77145322
134water-soluble vitamin biosynthetic process (GO:0042364)2.76844172
135action potential (GO:0001508)2.76542222
136cilium movement (GO:0003341)2.76312019
137acetyl-CoA metabolic process (GO:0006084)2.75277969
138positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.74521907
139nucleobase catabolic process (GO:0046113)2.73039272
140positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71998761
141regulation of hippo signaling (GO:0035330)2.67985833
142phosphatidylinositol acyl-chain remodeling (GO:0036149)2.67574644
143vitamin transport (GO:0051180)2.66899701
144hindbrain development (GO:0030902)2.66737687
145protein localization to cilium (GO:0061512)2.66285383
146bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65324415
147auditory receptor cell stereocilium organization (GO:0060088)2.64741749
148regulation of gene silencing by RNA (GO:0060966)2.63074113
149regulation of posttranscriptional gene silencing (GO:0060147)2.63074113
150regulation of gene silencing by miRNA (GO:0060964)2.63074113
151glycerophospholipid catabolic process (GO:0046475)2.62567390
152detection of mechanical stimulus involved in sensory perception (GO:0050974)2.61769598
153G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61676510
154positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.60966216
155benzene-containing compound metabolic process (GO:0042537)2.60599603
156intestinal absorption (GO:0050892)2.59866083
157aromatic amino acid family catabolic process (GO:0009074)2.58669488
158cilium morphogenesis (GO:0060271)2.57739540
159pentose-phosphate shunt (GO:0006098)2.57344684
160postsynaptic membrane organization (GO:0001941)2.56510210
161NAD biosynthetic process (GO:0009435)2.56000950
162photoreceptor cell maintenance (GO:0045494)2.55888380
163cilium organization (GO:0044782)2.55150300
164positive regulation of lipid storage (GO:0010884)2.52762535
165sialylation (GO:0097503)2.52396681
166negative regulation of reactive oxygen species metabolic process (GO:2000378)2.51933928
167axonemal dynein complex assembly (GO:0070286)2.51773769
168cellular response to arsenic-containing substance (GO:0071243)2.50930359
169cAMP catabolic process (GO:0006198)2.50702799
170nitric oxide biosynthetic process (GO:0006809)2.50250730
171* regulation of pH (GO:0006885)2.50229402
172inner ear receptor stereocilium organization (GO:0060122)2.49912925
173production of molecular mediator of immune response (GO:0002440)2.49384815
174kidney morphogenesis (GO:0060993)2.48697010
175retinal cone cell development (GO:0046549)2.48138679
176transmission of nerve impulse (GO:0019226)2.47707277
177positive regulation of sodium ion transmembrane transport (GO:1902307)2.47233120
178cilium assembly (GO:0042384)2.47103116
179cell proliferation in forebrain (GO:0021846)2.46486469
180DNA methylation involved in gamete generation (GO:0043046)2.45082419
181neuronal action potential propagation (GO:0019227)2.44860051
182lipid storage (GO:0019915)2.44531900
183oligosaccharide metabolic process (GO:0009311)2.43951365
184photoreceptor cell development (GO:0042461)2.43136813
185exogenous drug catabolic process (GO:0042738)2.42784398
186regulation of nuclear cell cycle DNA replication (GO:0033262)2.41762360
187negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39178805
188rhodopsin mediated signaling pathway (GO:0016056)2.38972223
189regulation of rhodopsin mediated signaling pathway (GO:0022400)2.38353533
190drug catabolic process (GO:0042737)2.38141732
191regulation of cilium movement (GO:0003352)2.37466374
192neurotransmitter metabolic process (GO:0042133)2.37250634
193positive regulation of fatty acid transport (GO:2000193)2.36939264
194oxidative demethylation (GO:0070989)2.36493069
195regulation of translation, ncRNA-mediated (GO:0045974)2.34448361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human4.29110249
2* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.93434403
3ZNF274_21170338_ChIP-Seq_K562_Hela3.58354075
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.56987072
5VDR_22108803_ChIP-Seq_LS180_Human3.23840878
6GBX2_23144817_ChIP-Seq_PC3_Human3.20741028
7ESR1_15608294_ChIP-ChIP_MCF-7_Human3.04116677
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.90349212
9SOX2_27498859_Chip-Seq_STOMACH_Mouse2.85964790
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.80391667
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74325537
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62276601
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61207720
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30684596
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.24906965
16ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.18528901
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14833282
18TAF15_26573619_Chip-Seq_HEK293_Human2.08545680
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07368237
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.06639166
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00317997
22SOX2_20726797_ChIP-Seq_SW620_Human1.95558150
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95477410
24* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90805442
25P300_19829295_ChIP-Seq_ESCs_Human1.90428994
26EWS_26573619_Chip-Seq_HEK293_Human1.86012780
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85500586
28* FLI1_27457419_Chip-Seq_LIVER_Mouse1.83276404
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82766666
30GATA4_25053715_ChIP-Seq_YYC3_Human1.81919453
31ER_23166858_ChIP-Seq_MCF-7_Human1.79722680
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78582253
33REST_21632747_ChIP-Seq_MESCs_Mouse1.73977536
34FUS_26573619_Chip-Seq_HEK293_Human1.71361671
35RXR_22108803_ChIP-Seq_LS180_Human1.70843434
36CLOCK_20551151_ChIP-Seq_293T_Human1.67584018
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.67489092
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66834642
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.66024176
40AR_21572438_ChIP-Seq_LNCaP_Human1.62981071
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61325319
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.59298314
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57769010
44AHR_22903824_ChIP-Seq_MCF-7_Human1.57027451
45STAT3_23295773_ChIP-Seq_U87_Human1.55893711
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55413896
47* KLF5_25053715_ChIP-Seq_YYC3_Human1.55403601
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55267546
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52326629
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52203107
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51875652
52* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50953483
53* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48930853
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48521651
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47824285
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46390779
57TP53_16413492_ChIP-PET_HCT116_Human1.46270471
58RNF2_27304074_Chip-Seq_NSC_Mouse1.45908545
59TCF4_23295773_ChIP-Seq_U87_Human1.45879590
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.45090095
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44362695
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44104576
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43372224
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43035264
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.40118770
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39719730
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39719730
68IRF1_19129219_ChIP-ChIP_H3396_Human1.39559073
69* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39411014
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.38975122
71TP53_22573176_ChIP-Seq_HFKS_Human1.37925643
72AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37111372
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35673382
74CBP_20019798_ChIP-Seq_JUKART_Human1.35673382
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.33786598
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33336840
77DROSHA_22980978_ChIP-Seq_HELA_Human1.30304866
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30070142
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29929640
80RUNX2_22187159_ChIP-Seq_PCA_Human1.29046285
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28366648
82LXR_22158963_ChIP-Seq_LIVER_Mouse1.27515524
83* SMAD3_21741376_ChIP-Seq_EPCs_Human1.26581412
84LXR_22292898_ChIP-Seq_THP-1_Human1.25249978
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25044947
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.24872766
87SOX2_19829295_ChIP-Seq_ESCs_Human1.24737907
88NANOG_19829295_ChIP-Seq_ESCs_Human1.24737907
89GATA6_25053715_ChIP-Seq_YYC3_Human1.24717919
90* EP300_21415370_ChIP-Seq_HL-1_Mouse1.24500658
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24334168
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23750525
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.23750525
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23673495
95* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23535982
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23323725
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22470818
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21307972
99SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19657992
100IGF1R_20145208_ChIP-Seq_DFB_Human1.19539052
101TCF4_22108803_ChIP-Seq_LS180_Human1.19249603
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18643543
103TP63_17297297_ChIP-ChIP_HaCaT_Human1.18520943
104GATA3_21878914_ChIP-Seq_MCF-7_Human1.18312271
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18292170
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17662145
107NCOR_22424771_ChIP-Seq_293T_Human1.17541965
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17315147
109* SMAD4_21741376_ChIP-Seq_EPCs_Human1.16944461
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.15578881
111KDM2B_26808549_Chip-Seq_K562_Human1.15475443
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14900821
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.14280551
114SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14257023
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14245632
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13684578
117RACK7_27058665_Chip-Seq_MCF-7_Human1.13230572
118IRF8_27001747_Chip-Seq_BMDM_Mouse1.12426754
119EZH2_22144423_ChIP-Seq_EOC_Human1.12039346
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11994274
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11897086
122SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11373423
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11133943
124MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10756296
125SALL1_21062744_ChIP-ChIP_HESCs_Human1.10687463
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10425350
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10056181
128ARNT_22903824_ChIP-Seq_MCF-7_Human1.09836415
129REST_18959480_ChIP-ChIP_MESCs_Mouse1.09420462
130GATA2_21666600_ChIP-Seq_HMVEC_Human1.09163542
131ZNF263_19887448_ChIP-Seq_K562_Human1.08982859
132* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08535406
133GATA3_24758297_ChIP-Seq_MCF-7_Human1.07445617
134NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07181799
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07181799
136SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07095378
137RNF2_27304074_Chip-Seq_ESCs_Mouse1.06890435
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06290230
139* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05911769
140* EZH2_27294783_Chip-Seq_NPCs_Mouse1.04804497
141MYC_18940864_ChIP-ChIP_HL60_Human1.04591658
142AR_20517297_ChIP-Seq_VCAP_Human1.04563583
143FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04273814
144* NFE2_27457419_Chip-Seq_LIVER_Mouse1.03578773
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03407036
146TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02231306
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02203715
148P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01798825
149RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00758527
150IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00254876
151RXR_22158963_ChIP-Seq_LIVER_Mouse0.99579068
152* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99477580
153TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99159688
154HOXB7_26014856_ChIP-Seq_BT474_Human0.98765239
155SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98665772
156* NANOG_18555785_Chip-Seq_ESCs_Mouse0.97643591
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.96770429
158FOXA2_19822575_ChIP-Seq_HepG2_Human0.96085318
159TBX20_22328084_ChIP-Seq_HEART_Mouse0.95173371
160TBX20_22080862_ChIP-Seq_HEART_Mouse0.95173371
161TP53_18474530_ChIP-ChIP_U2OS_Human0.95006930
162KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93746365
163SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93384238
164KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92903814
165CJUN_26792858_Chip-Seq_BT549_Human0.92762452
166SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92265652
167IRF8_21731497_ChIP-ChIP_J774_Mouse0.92093410
168SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91254716
169VDR_24787735_ChIP-Seq_THP-1_Human0.90482108
170SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90064707
171CDX2_20551321_ChIP-Seq_CACO-2_Human0.89542368
172GATA1_19941826_ChIP-Seq_K562_Human0.88378975
173PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88290684
174* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88149894
175BCAT_22108803_ChIP-Seq_LS180_Human0.87778271
176FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87494045
177EGR1_19032775_ChIP-ChIP_M12_Human0.87449003
178JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87379627
179TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86053838
180JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85784219
181GATA2_19941826_ChIP-Seq_K562_Human0.85769008
182TP63_23658742_ChIP-Seq_EP156T_Human0.85564794
183RARB_27405468_Chip-Seq_BRAIN_Mouse0.85015298
184AR_25329375_ChIP-Seq_VCAP_Human0.84863649
185STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84049216
186ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83242187
187ERG_21242973_ChIP-ChIP_JURKAT_Human0.83111159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001881_abnormal_mammary_gland6.14373943
2MP0010234_abnormal_vibrissa_follicle3.84140847
3* MP0001664_abnormal_digestion3.76611714
4MP0005083_abnormal_biliary_tract2.92249412
5MP0003303_peritoneal_inflammation2.74788040
6MP0003195_calcinosis2.73891723
7MP0001968_abnormal_touch/_nociception2.63217085
8* MP0001873_stomach_inflammation2.61531091
9* MP0000470_abnormal_stomach_morphology2.46541887
10MP0008877_abnormal_DNA_methylation2.46356911
11MP0003646_muscle_fatigue2.44761970
12MP0000569_abnormal_digit_pigmentation2.40704609
13MP0005551_abnormal_eye_electrophysiolog2.36719913
14MP0001666_abnormal_nutrient_absorption2.27696841
15MP0003787_abnormal_imprinting2.25222572
16MP0002736_abnormal_nociception_after2.24211590
17MP0002102_abnormal_ear_morphology2.22577793
18MP0004859_abnormal_synaptic_plasticity2.20408757
19MP0009046_muscle_twitch2.20186645
20MP0001986_abnormal_taste_sensitivity2.15697558
21MP0006292_abnormal_olfactory_placode2.09874281
22MP0004130_abnormal_muscle_cell2.07823109
23MP0002653_abnormal_ependyma_morphology2.03326628
24MP0004885_abnormal_endolymph2.02973760
25MP0003705_abnormal_hypodermis_morpholog2.01275146
26MP0008004_abnormal_stomach_pH12.8242766
27MP0004142_abnormal_muscle_tone1.99913800
28MP0002837_dystrophic_cardiac_calcinosis1.95414426
29MP0001485_abnormal_pinna_reflex1.91477198
30MP0008872_abnormal_physiological_respon1.90556809
31MP0006276_abnormal_autonomic_nervous1.88073258
32MP0002272_abnormal_nervous_system1.86518220
33MP0005645_abnormal_hypothalamus_physiol1.78345036
34MP0003878_abnormal_ear_physiology1.75275298
35MP0005377_hearing/vestibular/ear_phenot1.75275298
36MP0000627_abnormal_mammary_gland1.74622491
37MP0003300_gastrointestinal_ulcer1.73632249
38MP0000427_abnormal_hair_cycle1.72672940
39MP0004043_abnormal_pH_regulation1.71712093
40MP0004264_abnormal_extraembryonic_tissu1.69928647
41MP0003075_altered_response_to1.69543193
42MP0008875_abnormal_xenobiotic_pharmacok1.69247355
43MP0002735_abnormal_chemical_nociception1.67013623
44MP0005646_abnormal_pituitary_gland1.66974667
45MP0004133_heterotaxia1.66782975
46MP0002064_seizures1.64041798
47MP0005165_increased_susceptibility_to1.63293974
48MP0002572_abnormal_emotion/affect_behav1.59395472
49MP0006072_abnormal_retinal_apoptosis1.57189516
50MP0004742_abnormal_vestibular_system1.56815626
51MP0002733_abnormal_thermal_nociception1.55871067
52MP0001486_abnormal_startle_reflex1.55538918
53MP0004510_myositis1.54612541
54* MP0001663_abnormal_digestive_system1.54240189
55MP0004145_abnormal_muscle_electrophysio1.53530225
56MP0002876_abnormal_thyroid_physiology1.53428543
57MP0000631_abnormal_neuroendocrine_gland1.50239386
58MP0003806_abnormal_nucleotide_metabolis1.49931953
59MP0005253_abnormal_eye_physiology1.48651875
60MP0001970_abnormal_pain_threshold1.48545208
61MP0004185_abnormal_adipocyte_glucose1.48374908
62MP0002938_white_spotting1.47871948
63MP0000372_irregular_coat_pigmentation1.42033050
64MP0001919_abnormal_reproductive_system1.41810935
65MP0005389_reproductive_system_phenotype1.40919699
66MP0002557_abnormal_social/conspecific_i1.38126155
67MP0003880_abnormal_central_pattern1.37273374
68MP0003191_abnormal_cellular_cholesterol1.34849809
69MP0005058_abnormal_lysosome_morphology1.34156884
70MP0004484_altered_response_of1.32734717
71MP0002638_abnormal_pupillary_reflex1.32191797
72MP0002928_abnormal_bile_duct1.30474873
73MP0002067_abnormal_sensory_capabilities1.29947504
74MP0004019_abnormal_vitamin_homeostasis1.27500340
75MP0002160_abnormal_reproductive_system1.27251963
76MP0005084_abnormal_gallbladder_morpholo1.25260607
77* MP0005381_digestive/alimentary_phenotyp1.24746419
78MP0002734_abnormal_mechanical_nocicepti1.22526762
79MP0004924_abnormal_behavior1.22086703
80MP0005386_behavior/neurological_phenoty1.22086703
81MP0005174_abnormal_tail_pigmentation1.18848155
82MP0001440_abnormal_grooming_behavior1.18267088
83MP0002234_abnormal_pharynx_morphology1.16426424
84MP0005310_abnormal_salivary_gland1.15971124
85MP0005076_abnormal_cell_differentiation1.15318577
86MP0002163_abnormal_gland_morphology1.15300923
87MP0010329_abnormal_lipoprotein_level1.13972760
88MP0003718_maternal_effect1.13468598
89MP0000778_abnormal_nervous_system1.10347160
90MP0005085_abnormal_gallbladder_physiolo1.08031268
91MP0003137_abnormal_impulse_conducting1.07957567
92MP0002254_reproductive_system_inflammat1.06425825
93MP0005166_decreased_susceptibility_to1.05807796
94MP0003283_abnormal_digestive_organ1.04442058
95MP0005195_abnormal_posterior_eye1.03783634
96MP0002796_impaired_skin_barrier1.03272550
97MP0002118_abnormal_lipid_homeostasis1.03027006
98MP0000026_abnormal_inner_ear1.02246344
99MP0000230_abnormal_systemic_arterial1.01082118
100MP0008961_abnormal_basal_metabolism1.00145610
101MP0001905_abnormal_dopamine_level0.97696406
102MP0009840_abnormal_foam_cell0.96060141
103MP0001963_abnormal_hearing_physiology0.93723483
104MP0003252_abnormal_bile_duct0.93385151
105MP0004947_skin_inflammation0.91873850
106MP0002752_abnormal_somatic_nervous0.91352038
107MP0005423_abnormal_somatic_nervous0.90260930
108MP0005410_abnormal_fertilization0.89861739
109MP0005167_abnormal_blood-brain_barrier0.89541142
110MP0002419_abnormal_innate_immunity0.89332039
111MP0004215_abnormal_myocardial_fiber0.89254956
112MP0002909_abnormal_adrenal_gland0.88718148
113MP0004147_increased_porphyrin_level0.88497153
114MP0003121_genomic_imprinting0.88475139
115MP0003119_abnormal_digestive_system0.88466696
116MP0003122_maternal_imprinting0.87772817
117MP0002095_abnormal_skin_pigmentation0.87719441
118MP0004858_abnormal_nervous_system0.87123369
119MP0001984_abnormal_olfaction0.86244711
120MP0003329_amyloid_beta_deposits0.85569487
121MP0000490_abnormal_crypts_of0.85368656
122MP0008775_abnormal_heart_ventricle0.83684811
123MP0002184_abnormal_innervation0.83168768
124MP0009384_cardiac_valve_regurgitation0.83147602
125MP0000383_abnormal_hair_follicle0.83095152
126MP0005379_endocrine/exocrine_gland_phen0.83092966
127MP0003011_delayed_dark_adaptation0.82003061
128MP0005334_abnormal_fat_pad0.80943142
129MP0002229_neurodegeneration0.80581089
130MP0005666_abnormal_adipose_tissue0.79488377
131MP0005670_abnormal_white_adipose0.78908864
132MP0002971_abnormal_brown_adipose0.77528934
133MP0003172_abnormal_lysosome_physiology0.77152817
134MP0001529_abnormal_vocalization0.76367341
135MP0003879_abnormal_hair_cell0.76012322
136MP0002277_abnormal_respiratory_mucosa0.75692087
137MP0005584_abnormal_enzyme/coenzyme_acti0.74828837
138MP0003136_yellow_coat_color0.74765950
139MP0000049_abnormal_middle_ear0.74672964
140MP0002882_abnormal_neuron_morphology0.74333700
141MP0003566_abnormal_cell_adhesion0.73995077
142MP0003724_increased_susceptibility_to0.72946840
143MP0000477_abnormal_intestine_morphology0.72196830
144MP0001849_ear_inflammation0.71021980
145MP0003690_abnormal_glial_cell0.69312759
146MP0000604_amyloidosis0.68814862
147MP0005375_adipose_tissue_phenotype0.67860694
148MP0005395_other_phenotype0.66145170
149MP0001765_abnormal_ion_homeostasis0.65673837
150MP0006054_spinal_hemorrhage0.65618365
151MP0003635_abnormal_synaptic_transmissio0.64877024
152MP0002970_abnormal_white_adipose0.64831221
153MP0005636_abnormal_mineral_homeostasis0.64138609
154MP0001958_emphysema0.63604071
155MP0005360_urolithiasis0.62140754
156MP0003828_pulmonary_edema0.61951622
157MP0002009_preneoplasia0.61539138
158MP0003453_abnormal_keratinocyte_physiol0.60560714
159MP0010678_abnormal_skin_adnexa0.59175099
160MP0000343_altered_response_to0.58238545
161MP0002078_abnormal_glucose_homeostasis0.58179827
162MP0003448_altered_tumor_morphology0.54700418
163MP0002148_abnormal_hypersensitivity_rea0.54414933
164MP0008873_increased_physiological_sensi0.53067379
165MP0001533_abnormal_skeleton_physiology0.52640667
166MP0004270_analgesia0.51676734
167MP0010386_abnormal_urinary_bladder0.50813838
168MP0003953_abnormal_hormone_level0.49631871
169MP0004782_abnormal_surfactant_physiolog0.49280127
170MP0001851_eye_inflammation0.49022462
171MP0001501_abnormal_sleep_pattern0.48793832
172MP0000465_gastrointestinal_hemorrhage0.47781190
173MP0002693_abnormal_pancreas_physiology0.47628704
174MP0005452_abnormal_adipose_tissue0.47166738
175MP0002063_abnormal_learning/memory/cond0.47031546
176MP0003436_decreased_susceptibility_to0.46345789
177MP0005319_abnormal_enzyme/_coenzyme0.46328032
178MP0005448_abnormal_energy_balance0.45336027
179MP0002452_abnormal_antigen_presenting0.44669546
180MP0005266_abnormal_metabolism0.44275126
181MP0000609_abnormal_liver_physiology0.43655568
182* MP0001845_abnormal_inflammatory_respons0.43592717
183MP0002896_abnormal_bone_mineralization0.42165395
184MP0008469_abnormal_protein_level0.41803774
185MP0009745_abnormal_behavioral_response0.40316151
186MP0002139_abnormal_hepatobiliary_system0.40186815
187MP0009780_abnormal_chondrocyte_physiolo0.40012087

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)5.31305252
2Abnormality of purine metabolism (HP:0004352)5.08996266
3Abnormal number of erythroid precursors (HP:0012131)4.84453418
4Right ventricular cardiomyopathy (HP:0011663)4.78795859
5Pancreatic cysts (HP:0001737)4.51356733
6Axonal loss (HP:0003447)4.45856528
7Abnormality of midbrain morphology (HP:0002418)4.26479205
8Molar tooth sign on MRI (HP:0002419)4.26479205
9Abnormality of cells of the erythroid lineage (HP:0012130)4.15916646
10Pancreatic fibrosis (HP:0100732)4.14337860
11Arterial tortuosity (HP:0005116)4.10192400
12True hermaphroditism (HP:0010459)4.01822771
13Congenital stationary night blindness (HP:0007642)3.88919297
14Nephronophthisis (HP:0000090)3.75559175
15Tubulointerstitial fibrosis (HP:0005576)3.63498493
16Vascular tortuosity (HP:0004948)3.55122569
17Hyperventilation (HP:0002883)3.54452625
18Tubulointerstitial nephritis (HP:0001970)3.41184495
19Absent/shortened dynein arms (HP:0200106)3.32595802
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.32595802
21Vacuolated lymphocytes (HP:0001922)3.29077584
22Abnormality of the renal medulla (HP:0100957)3.23602485
23Stridor (HP:0010307)3.16170732
24Abnormality of the renal cortex (HP:0011035)3.13919122
25Attenuation of retinal blood vessels (HP:0007843)3.13850162
26Hyperuricemia (HP:0002149)3.11478383
27Increased purine levels (HP:0004368)3.11478383
28Amelogenesis imperfecta (HP:0000705)3.11014931
29Type II lissencephaly (HP:0007260)3.07996431
30Tubular atrophy (HP:0000092)3.04807772
31Increased cerebral lipofuscin (HP:0011813)2.97122183
32Cystic liver disease (HP:0006706)2.93910166
33Medial flaring of the eyebrow (HP:0010747)2.93582293
34Cerebral inclusion bodies (HP:0100314)2.93521461
35Abolished electroretinogram (ERG) (HP:0000550)2.89055756
36Abnormal respiratory motile cilium morphology (HP:0005938)2.86918099
37Abnormal respiratory epithelium morphology (HP:0012253)2.86918099
38Thin bony cortex (HP:0002753)2.84658977
39Abnormality of nucleobase metabolism (HP:0010932)2.83430995
40Large for gestational age (HP:0001520)2.82945520
41Progressive cerebellar ataxia (HP:0002073)2.82745972
42Polydipsia (HP:0001959)2.79213743
43Abnormal drinking behavior (HP:0030082)2.79213743
44Genetic anticipation (HP:0003743)2.79014299
45Congenital, generalized hypertrichosis (HP:0004540)2.78077348
46Abnormality of the vitamin B12 metabolism (HP:0004341)2.74867899
47Inability to walk (HP:0002540)2.74383861
48Aortic aneurysm (HP:0004942)2.71976627
49Increased corneal curvature (HP:0100692)2.71917028
50Keratoconus (HP:0000563)2.71917028
51Syncope (HP:0001279)2.68400764
52Protruding tongue (HP:0010808)2.67929079
53Chronic hepatic failure (HP:0100626)2.63606117
54Congenital ichthyosiform erythroderma (HP:0007431)2.60904235
55Cortical dysplasia (HP:0002539)2.60239860
56Decreased circulating renin level (HP:0003351)2.60135468
57Neurodegeneration (HP:0002180)2.59740071
58Abnormal rod and cone electroretinograms (HP:0008323)2.59415836
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59373063
60Abnormality of alanine metabolism (HP:0010916)2.59373063
61Hyperalaninemia (HP:0003348)2.59373063
62Visual hallucinations (HP:0002367)2.58332592
63Abnormality of renal excretion (HP:0011036)2.57636209
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57517796
65Aortic dissection (HP:0002647)2.57481799
66Abnormality of vitamin B metabolism (HP:0004340)2.55609117
67Sclerocornea (HP:0000647)2.55106342
68Osteolytic defects of the hand bones (HP:0009699)2.54168474
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.54168474
70Eczematoid dermatitis (HP:0000976)2.50458306
71Megaloblastic anemia (HP:0001889)2.50457092
72Glomerulosclerosis (HP:0000096)2.50023374
73Decreased central vision (HP:0007663)2.49499898
74Renal salt wasting (HP:0000127)2.47822440
75Gait imbalance (HP:0002141)2.47195158
76Gaze-evoked nystagmus (HP:0000640)2.46720012
77Progressive inability to walk (HP:0002505)2.43935712
78Cerebral aneurysm (HP:0004944)2.43921857
79Furrowed tongue (HP:0000221)2.43435120
80Subcapsular cataract (HP:0000523)2.43383094
81Bony spicule pigmentary retinopathy (HP:0007737)2.40801331
82Dysostosis multiplex (HP:0000943)2.39587210
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.34738047
84Concave nail (HP:0001598)2.33902585
85Lissencephaly (HP:0001339)2.33866476
86Curly hair (HP:0002212)2.33205190
87Goiter (HP:0000853)2.32838513
88Clumsiness (HP:0002312)2.31806121
89Congenital primary aphakia (HP:0007707)2.31680899
90Abnormal ciliary motility (HP:0012262)2.30942358
91Ketoacidosis (HP:0001993)2.29683513
92Frequent falls (HP:0002359)2.29436141
93Pendular nystagmus (HP:0012043)2.28820902
94Supranuclear gaze palsy (HP:0000605)2.26499100
95Nephrogenic diabetes insipidus (HP:0009806)2.26438796
96Ventricular fibrillation (HP:0001663)2.26263757
97Pili torti (HP:0003777)2.25825085
98Patellar aplasia (HP:0006443)2.24314921
99Broad-based gait (HP:0002136)2.24139923
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.22453255
101Hypoplasia of the fovea (HP:0007750)2.22331952
102Aplasia/Hypoplasia of the fovea (HP:0008060)2.22331952
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22054985
104Pustule (HP:0200039)2.22004808
105Metaphyseal dysplasia (HP:0100255)2.21247762
106Polyuria (HP:0000103)2.21141467
107Bilateral microphthalmos (HP:0007633)2.21044014
108Interstitial pulmonary disease (HP:0006530)2.20158494
109Protuberant abdomen (HP:0001538)2.20016226
110Febrile seizures (HP:0002373)2.19671719
111Congenital hepatic fibrosis (HP:0002612)2.19547665
112Aplasia/Hypoplasia of the patella (HP:0006498)2.17506771
113Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16949223
114Nephritis (HP:0000123)2.16803206
115Neurofibrillary tangles (HP:0002185)2.16539100
116Male pseudohermaphroditism (HP:0000037)2.13810320
117Abnormality of vitamin metabolism (HP:0100508)2.11658419
118Spastic tetraparesis (HP:0001285)2.11584285
119Hematochezia (HP:0002573)2.11130617
120Poor eye contact (HP:0000817)2.11099785
121Fatigue (HP:0012378)2.11091065
122Anencephaly (HP:0002323)2.10745060
123Aplasia/Hypoplasia of the tongue (HP:0010295)2.10098284
124Abnormal social behavior (HP:0012433)2.09272701
125Impaired social interactions (HP:0000735)2.09272701
126Congenital sensorineural hearing impairment (HP:0008527)2.09017525
127Cerebellar dysplasia (HP:0007033)2.07483932
128Recurrent bacterial skin infections (HP:0005406)2.04359478
129Focal motor seizures (HP:0011153)2.03005154
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02713980
131Urinary glycosaminoglycan excretion (HP:0003541)2.02147049
132Mucopolysacchariduria (HP:0008155)2.02147049
133Renal cortical cysts (HP:0000803)1.98890203
134Abnormality of polysaccharide metabolism (HP:0011012)1.98825607
135Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98825607
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98825607
137Apathy (HP:0000741)1.97254606
138Hemiparesis (HP:0001269)1.96969354
139Focal seizures (HP:0007359)1.95946550
140Abnormality of liposaccharide metabolism (HP:0010968)1.95798654
141Abnormality of glycosphingolipid metabolism (HP:0004343)1.95798654
142Abnormality of glycolipid metabolism (HP:0010969)1.95798654
143Genital tract atresia (HP:0001827)1.95337198
144Abnormality of macrophages (HP:0004311)1.94654175
145Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94398659
146Vaginal atresia (HP:0000148)1.93351729
147Abnormality of the pons (HP:0007361)1.93066108
148Hypoplasia of the pons (HP:0012110)1.92017675
149Hyperglycinuria (HP:0003108)1.91276373
150Vascular calcification (HP:0004934)1.91224800
151Bile duct proliferation (HP:0001408)1.91114209
152Abnormal biliary tract physiology (HP:0012439)1.91114209
153Agitation (HP:0000713)1.89202933
154Recurrent gram-negative bacterial infections (HP:0005420)1.88489523
155Rapidly progressive (HP:0003678)1.85981008
156Recurrent abscess formation (HP:0002722)1.85525867
157Aneurysm (HP:0002617)1.85346165
158Hyperkalemia (HP:0002153)1.84237981
159Abnormal respiratory motile cilium physiology (HP:0012261)1.84160464
160Fair hair (HP:0002286)1.84089114
161Dialeptic seizures (HP:0011146)1.83411339
162Severe muscular hypotonia (HP:0006829)1.82586129
163Diminished motivation (HP:0000745)1.82180058
164Achilles tendon contracture (HP:0001771)1.80439563
165Hypoplasia of dental enamel (HP:0006297)1.80121058
166Bone cyst (HP:0012062)1.78737907
167Striae distensae (HP:0001065)1.78721673
168Constricted visual fields (HP:0001133)1.78545309
169Hypothermia (HP:0002045)1.78300001
170Postaxial foot polydactyly (HP:0001830)1.78229336
171Periodontitis (HP:0000704)1.77227992
172Abdominal distention (HP:0003270)1.76698946
173Optic nerve hypoplasia (HP:0000609)1.76399178
174Abnormality of the fovea (HP:0000493)1.76051821
175Paresthesia (HP:0003401)1.75651406
176Abnormality of calcium-phosphate metabolism (HP:0100530)1.75367381
177Tubulointerstitial abnormality (HP:0001969)1.74931988
178Epiphyseal dysplasia (HP:0002656)1.74491320
179Chorioretinal atrophy (HP:0000533)1.73947152
180Abnormal urine output (HP:0012590)1.73333766
181Tachypnea (HP:0002789)1.73324343
182Ventricular arrhythmia (HP:0004308)1.72057889
183Chronic sinusitis (HP:0011109)1.72031579
184Birth length less than 3rd percentile (HP:0003561)1.71751284
185Deep venous thrombosis (HP:0002625)1.71604505
186Hyperactive renin-angiotensin system (HP:0000841)1.71314838
187Absent speech (HP:0001344)1.71191196
188Hypoplastic ischia (HP:0003175)1.70832911
189Long toe (HP:0010511)1.70401495
190Woolly hair (HP:0002224)1.70103579
191Abnormality of vision evoked potentials (HP:0000649)1.69751746
192Poor coordination (HP:0002370)1.69509551
193Premature loss of primary teeth (HP:0006323)1.69217942
194Cardiovascular calcification (HP:0011915)1.69123145
195Enlarged penis (HP:0000040)1.68769129
196Retinitis pigmentosa (HP:0000510)1.67323123
197Global brain atrophy (HP:0002283)1.64842373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB44.89700890
2PKN23.86820272
3TRIB33.53599822
4ADRBK23.48094309
5CAMK1D3.37627790
6BMPR1B2.86384801
7CAMK1G2.80144870
8KSR22.77278540
9CASK2.71063453
10GRK12.67386656
11INSRR2.66096842
12PINK12.51546314
13ZAK2.47947336
14MST42.44946629
15WNK32.43277306
16MAP3K92.40644629
17ACVR1B2.38008021
18SIK12.26669062
19TLK12.15464424
20MST1R2.10546617
21EEF2K2.08533642
22PDK22.06527587
23FGR2.00297009
24MAP4K21.94810459
25RIPK41.94370495
26MAPK131.89422744
27ERN11.86561642
28PDK31.80382025
29PDK41.80382025
30MAP3K131.79832644
31TXK1.73736999
32OXSR11.72141130
33TGFBR21.53282771
34PNCK1.47248029
35MAP3K41.46631758
36LRRK21.44299094
37MARK11.43918413
38PDGFRB1.43906552
39STK101.42959520
40ZAP701.42829646
41PTK61.41371487
42RIPK11.39216563
43DAPK21.38494771
44MAP3K21.34466575
45CAMKK21.33602019
46FER1.31166966
47ADRBK11.28578326
48MAP4K11.27685983
49MOS1.27565197
50SIK21.20438490
51MAP3K71.18804530
52FES1.18291867
53TNIK1.17251057
54PTK2B1.16299431
55PRKCG1.14226214
56BCKDK1.11782447
57CAMKK11.10772968
58ARAF1.10645095
59DYRK21.10277817
60PRKAA21.07211930
61DMPK1.05217675
62RET1.04918105
63NTRK31.02726030
64MAPK151.02140525
65MAP2K71.02080440
66PAK30.97506538
67LMTK20.97429258
68MKNK20.96565720
69MYLK0.95220798
70TTN0.94479622
71CDK190.94351142
72TGFBR10.94178441
73TIE10.93873565
74GRK60.92787003
75MAP2K10.90502905
76NME10.90180851
77FRK0.89701745
78NTRK20.89311686
79PRKCE0.88933455
80PAK60.87999861
81STK380.87289867
82PDPK10.85190207
83MAPKAPK30.84989516
84PDK10.82973808
85BMX0.82248367
86EPHA40.81668702
87KSR10.80929598
88TYRO30.80309152
89RAF10.78683117
90MET0.75974424
91STK110.75133365
92PHKG10.74548594
93PHKG20.74548594
94GRK50.74161214
95PIK3CG0.73329550
96RPS6KA20.71378553
97CSNK1G20.70958491
98NEK20.67822338
99PRKD30.66913837
100TAOK10.65983808
101MUSK0.65607437
102TEC0.64857490
103NTRK10.64574839
104DDR20.64316733
105PKN10.64162224
106EPHB10.63819069
107MAP3K120.62403321
108IRAK10.62326778
109PLK20.60762092
110MATK0.60055029
111PTK20.58922797
112TRPM70.58690935
113GRK70.58334681
114CDK90.57311611
115MAP3K10.57023551
116MAPKAPK50.56465448
117JAK20.56021940
118CSK0.55922029
119STK38L0.55496635
120PRKACA0.54593962
121FGFR20.54415602
122DAPK10.54140878
123ITK0.52937026
124OBSCN0.51870894
125CSNK1G10.51614548
126MAP2K60.51401353
127WNK40.50731723
128RPS6KA50.50021108
129TAOK30.49278027
130CSNK1G30.49214173
131KIT0.49196787
132MAP2K40.48784277
133TBK10.48654434
134VRK10.48309472
135MINK10.48207511
136PRKCZ0.47917482
137IKBKB0.47284654
138FYN0.46717616
139BCR0.44375894
140PRKCH0.44136455
141EPHA30.44104456
142RPS6KA60.43983288
143PRKCA0.43279658
144MAP2K20.42557037
145ERBB20.42334193
146PLK40.41940500
147MAPK120.41589271
148LIMK10.41472853
149ABL20.40779162
150TAF10.40747262
151STK30.40674304
152CAMK2A0.40321442
153CSNK1A10.40242257
154PRKCQ0.39610284
155PIK3CA0.39152514
156STK390.39068640
157JAK10.38637311
158CSNK1A1L0.38504287
159PRKAA10.38123776
160LATS10.37350795
161CDK50.37083118
162SYK0.36954058
163MAP3K60.36745707
164EGFR0.35969979
165CAMK10.35828350
166DYRK1A0.35784549
167TRIM280.35511818
168BMPR20.35230778
169PRKG10.34860159
170PRKCI0.34686773
171CHUK0.34566280
172MAP3K80.34365087
173CSNK1D0.34113717
174SRC0.33451728
175MAP3K110.31850959
176WEE10.31384087
177SGK20.31137739
178NUAK10.30157033
179CAMK40.30118200

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.99993058
2Caffeine metabolism_Homo sapiens_hsa002324.93555218
3Collecting duct acid secretion_Homo sapiens_hsa049664.32657919
4Phototransduction_Homo sapiens_hsa047442.93181457
5* Gastric acid secretion_Homo sapiens_hsa049712.80763397
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.77977969
7Butanoate metabolism_Homo sapiens_hsa006502.38705855
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.20018996
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.16222912
10Selenocompound metabolism_Homo sapiens_hsa004502.14903480
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14470840
12Tryptophan metabolism_Homo sapiens_hsa003801.99777739
13Galactose metabolism_Homo sapiens_hsa000521.91167446
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90523687
15Olfactory transduction_Homo sapiens_hsa047401.85673462
16Morphine addiction_Homo sapiens_hsa050321.73207139
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72737227
18Fat digestion and absorption_Homo sapiens_hsa049751.70067217
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69005187
20Taste transduction_Homo sapiens_hsa047421.66373223
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62765879
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59080081
23ABC transporters_Homo sapiens_hsa020101.57407839
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52386495
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.48722094
26Propanoate metabolism_Homo sapiens_hsa006401.48507910
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46303761
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45635053
29Pyruvate metabolism_Homo sapiens_hsa006201.44398140
30Fatty acid metabolism_Homo sapiens_hsa012121.42354015
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36856375
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.36280160
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.30607673
34Serotonergic synapse_Homo sapiens_hsa047261.29082949
35Cardiac muscle contraction_Homo sapiens_hsa042601.25141068
36Arachidonic acid metabolism_Homo sapiens_hsa005901.24223715
37Lysosome_Homo sapiens_hsa041421.18928951
38Homologous recombination_Homo sapiens_hsa034401.15080577
39Mineral absorption_Homo sapiens_hsa049781.14367202
40Ovarian steroidogenesis_Homo sapiens_hsa049131.10841900
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10634601
42Parkinsons disease_Homo sapiens_hsa050121.10406804
43Vitamin digestion and absorption_Homo sapiens_hsa049771.10114662
44Retinol metabolism_Homo sapiens_hsa008301.09721369
45Salivary secretion_Homo sapiens_hsa049701.08853582
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08756083
47Prolactin signaling pathway_Homo sapiens_hsa049171.06899628
48Basal transcription factors_Homo sapiens_hsa030221.05565020
49Peroxisome_Homo sapiens_hsa041461.04598581
50Histidine metabolism_Homo sapiens_hsa003401.03249721
51Pancreatic secretion_Homo sapiens_hsa049721.01969966
52Sulfur metabolism_Homo sapiens_hsa009201.00296053
53Calcium signaling pathway_Homo sapiens_hsa040200.97962591
54Glycerolipid metabolism_Homo sapiens_hsa005610.97830639
55RNA polymerase_Homo sapiens_hsa030200.96632966
56Protein export_Homo sapiens_hsa030600.95918146
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94126022
58Asthma_Homo sapiens_hsa053100.93344902
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93225824
60Long-term potentiation_Homo sapiens_hsa047200.92806130
61Fanconi anemia pathway_Homo sapiens_hsa034600.92593973
62Chemical carcinogenesis_Homo sapiens_hsa052040.92147039
63Synaptic vesicle cycle_Homo sapiens_hsa047210.90639305
64Glutathione metabolism_Homo sapiens_hsa004800.89391421
65PPAR signaling pathway_Homo sapiens_hsa033200.88722150
66Tuberculosis_Homo sapiens_hsa051520.88076920
67Linoleic acid metabolism_Homo sapiens_hsa005910.86845686
68beta-Alanine metabolism_Homo sapiens_hsa004100.83348562
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80656620
70Cocaine addiction_Homo sapiens_hsa050300.79034092
71Alzheimers disease_Homo sapiens_hsa050100.78614380
72Primary immunodeficiency_Homo sapiens_hsa053400.75944367
73Vibrio cholerae infection_Homo sapiens_hsa051100.75885690
74Ether lipid metabolism_Homo sapiens_hsa005650.73044827
75Huntingtons disease_Homo sapiens_hsa050160.72830780
76Rheumatoid arthritis_Homo sapiens_hsa053230.70224942
77Thyroid hormone synthesis_Homo sapiens_hsa049180.69734533
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69696774
79Graft-versus-host disease_Homo sapiens_hsa053320.69231002
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68536877
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67541391
82GnRH signaling pathway_Homo sapiens_hsa049120.66952245
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65960138
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.65104840
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65102720
86VEGF signaling pathway_Homo sapiens_hsa043700.64661749
87Bile secretion_Homo sapiens_hsa049760.64402691
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64257642
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63526121
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63162283
91Type I diabetes mellitus_Homo sapiens_hsa049400.62990895
92Fatty acid degradation_Homo sapiens_hsa000710.62531473
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61549296
94One carbon pool by folate_Homo sapiens_hsa006700.61260767
95Phagosome_Homo sapiens_hsa041450.60007736
96Osteoclast differentiation_Homo sapiens_hsa043800.59624910
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.59216832
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59182767
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58858936
100Renin secretion_Homo sapiens_hsa049240.58652813
101Allograft rejection_Homo sapiens_hsa053300.58041134
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57414449
103RNA degradation_Homo sapiens_hsa030180.57135663
104Estrogen signaling pathway_Homo sapiens_hsa049150.56989016
105Dorso-ventral axis formation_Homo sapiens_hsa043200.56114586
106Autoimmune thyroid disease_Homo sapiens_hsa053200.56086482
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55534083
108Regulation of autophagy_Homo sapiens_hsa041400.55367853
109Oxytocin signaling pathway_Homo sapiens_hsa049210.52935607
110Nitrogen metabolism_Homo sapiens_hsa009100.52836238
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52232692
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51169370
113Glutamatergic synapse_Homo sapiens_hsa047240.51019376
114Circadian entrainment_Homo sapiens_hsa047130.50942206
115Endocytosis_Homo sapiens_hsa041440.49462168
116Leishmaniasis_Homo sapiens_hsa051400.48341115
117Cholinergic synapse_Homo sapiens_hsa047250.47526829
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.47336772
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46864452
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46719444
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46395264
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.46225738
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46080654
124Insulin secretion_Homo sapiens_hsa049110.46032162
125Metabolic pathways_Homo sapiens_hsa011000.45428262
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44865904
127Pancreatic cancer_Homo sapiens_hsa052120.44838978
128Other glycan degradation_Homo sapiens_hsa005110.44527307
129Salmonella infection_Homo sapiens_hsa051320.41751436
130Glucagon signaling pathway_Homo sapiens_hsa049220.41748924
131Carbon metabolism_Homo sapiens_hsa012000.41211690
132Dopaminergic synapse_Homo sapiens_hsa047280.40381646
133Insulin resistance_Homo sapiens_hsa049310.39889875
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39243280
135Long-term depression_Homo sapiens_hsa047300.38864765
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38711511
137B cell receptor signaling pathway_Homo sapiens_hsa046620.38020705
138AMPK signaling pathway_Homo sapiens_hsa041520.37505441
139Sulfur relay system_Homo sapiens_hsa041220.36767946
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36596961
141Toxoplasmosis_Homo sapiens_hsa051450.36452705
142cAMP signaling pathway_Homo sapiens_hsa040240.35616823
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35545714
144Amoebiasis_Homo sapiens_hsa051460.35107181
145Nicotine addiction_Homo sapiens_hsa050330.35033831
146Tight junction_Homo sapiens_hsa045300.34730383
147Choline metabolism in cancer_Homo sapiens_hsa052310.33938158
148Amphetamine addiction_Homo sapiens_hsa050310.33920473
149GABAergic synapse_Homo sapiens_hsa047270.33672614
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.33638400
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33353522
152N-Glycan biosynthesis_Homo sapiens_hsa005100.33269813
153Oxidative phosphorylation_Homo sapiens_hsa001900.33213320
154Hedgehog signaling pathway_Homo sapiens_hsa043400.32863863
155Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31712835

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