SLC9A3R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.71321754
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.06217885
3L-phenylalanine catabolic process (GO:0006559)5.06217885
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.05732575
5L-phenylalanine metabolic process (GO:0006558)5.05732575
6cysteine metabolic process (GO:0006534)4.96672264
7aromatic amino acid family catabolic process (GO:0009074)4.80045110
8regulation of cholesterol esterification (GO:0010872)4.68428040
9sulfur amino acid catabolic process (GO:0000098)4.65343070
10glyoxylate metabolic process (GO:0046487)4.60945306
11tryptophan catabolic process (GO:0006569)4.59136975
12indole-containing compound catabolic process (GO:0042436)4.59136975
13indolalkylamine catabolic process (GO:0046218)4.59136975
14alpha-linolenic acid metabolic process (GO:0036109)4.58423039
15negative regulation of sterol transport (GO:0032372)4.56817703
16negative regulation of cholesterol transport (GO:0032375)4.56817703
17intestinal cholesterol absorption (GO:0030299)4.55684827
18high-density lipoprotein particle remodeling (GO:0034375)4.55112689
19urea cycle (GO:0000050)4.54964991
20urea metabolic process (GO:0019627)4.54964991
21phospholipid efflux (GO:0033700)4.54840929
22kynurenine metabolic process (GO:0070189)4.44684341
23regulation of triglyceride catabolic process (GO:0010896)4.37308750
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.35297021
25homocysteine metabolic process (GO:0050667)4.34663767
26reverse cholesterol transport (GO:0043691)4.32904311
27tryptophan metabolic process (GO:0006568)4.29725436
28drug catabolic process (GO:0042737)4.29436000
29lysine metabolic process (GO:0006553)4.25896557
30lysine catabolic process (GO:0006554)4.25896557
31intestinal absorption (GO:0050892)4.21212013
32plasma lipoprotein particle assembly (GO:0034377)4.20164389
33nitrogen cycle metabolic process (GO:0071941)4.15720968
34regulation of cholesterol homeostasis (GO:2000188)4.14354683
35serine family amino acid catabolic process (GO:0009071)4.09932175
36bile acid biosynthetic process (GO:0006699)4.08019486
37antigen processing and presentation of endogenous antigen (GO:0019883)4.07279354
38plasma lipoprotein particle remodeling (GO:0034369)4.04610761
39protein-lipid complex remodeling (GO:0034368)4.04610761
40macromolecular complex remodeling (GO:0034367)4.04610761
41positive regulation of Cdc42 GTPase activity (GO:0043089)4.03398907
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.03022856
43negative regulation of cell killing (GO:0031342)4.03022856
44amino-acid betaine metabolic process (GO:0006577)4.01759100
45serine family amino acid biosynthetic process (GO:0009070)3.99623651
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.94616604
47protein-lipid complex assembly (GO:0065005)3.86516689
48flavonoid metabolic process (GO:0009812)3.85647818
49positive regulation of lipoprotein lipase activity (GO:0051006)3.85426945
50positive regulation of triglyceride lipase activity (GO:0061365)3.85426945
51serine family amino acid metabolic process (GO:0009069)3.82399842
52drug transmembrane transport (GO:0006855)3.82114713
53urate metabolic process (GO:0046415)3.77219346
54proline biosynthetic process (GO:0006561)3.75527093
55glycine metabolic process (GO:0006544)3.72268763
56cholesterol efflux (GO:0033344)3.71104397
57cellular modified amino acid catabolic process (GO:0042219)3.71006333
58Golgi transport vesicle coating (GO:0048200)3.70864732
59COPI coating of Golgi vesicle (GO:0048205)3.70864732
60drug transport (GO:0015893)3.68431855
61hepatocyte apoptotic process (GO:0097284)3.67699036
62NADH metabolic process (GO:0006734)3.66954671
63bile acid and bile salt transport (GO:0015721)3.66617057
64ethanol oxidation (GO:0006069)3.65121226
65bile acid metabolic process (GO:0008206)3.62534631
66lipoprotein metabolic process (GO:0042157)3.61789049
67regulation of gamma-delta T cell differentiation (GO:0045586)3.61531824
68negative regulation of fibrinolysis (GO:0051918)3.60742558
69cellular glucuronidation (GO:0052695)3.58654459
70protein carboxylation (GO:0018214)3.58577240
71peptidyl-glutamic acid carboxylation (GO:0017187)3.58577240
72cholesterol homeostasis (GO:0042632)3.57222406
73complement activation, alternative pathway (GO:0006957)3.56578964
74plasma lipoprotein particle clearance (GO:0034381)3.55762985
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.53885194
76antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.53885194
77very-low-density lipoprotein particle assembly (GO:0034379)3.53822042
78sterol homeostasis (GO:0055092)3.53093933
79aromatic amino acid family metabolic process (GO:0009072)3.52325122
80regulation of protein activation cascade (GO:2000257)3.50128317
81GDP-mannose metabolic process (GO:0019673)3.48275992
82regulation of bile acid biosynthetic process (GO:0070857)3.45602615
83alpha-amino acid catabolic process (GO:1901606)3.43409261
84phospholipid homeostasis (GO:0055091)3.41587521
85plasma lipoprotein particle organization (GO:0071827)3.38088642
86exogenous drug catabolic process (GO:0042738)3.37196136
87acylglycerol homeostasis (GO:0055090)3.36113846
88triglyceride homeostasis (GO:0070328)3.36113846
89glutamate metabolic process (GO:0006536)3.35019343
90proline metabolic process (GO:0006560)3.33706121
91low-density lipoprotein particle remodeling (GO:0034374)3.30989411
92positive regulation of triglyceride metabolic process (GO:0090208)3.29487951
93regulation of fibrinolysis (GO:0051917)3.29443395
94regulation of complement activation (GO:0030449)3.28636184
95thymic T cell selection (GO:0045061)3.27540513
96cellular amino acid catabolic process (GO:0009063)3.25679130
97protein-lipid complex subunit organization (GO:0071825)3.23846477
98response to nitrosative stress (GO:0051409)3.23311970
99angiotensin maturation (GO:0002003)3.21753624
100positive regulation of keratinocyte differentiation (GO:0045618)3.21577037
101uronic acid metabolic process (GO:0006063)3.21350645
102glucuronate metabolic process (GO:0019585)3.21350645
103regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.21027107
104interferon-gamma secretion (GO:0072643)3.20757824
105valine metabolic process (GO:0006573)3.20658603
106carnitine metabolic process (GO:0009437)3.19697371
107positive regulation of fatty acid biosynthetic process (GO:0045723)3.16802971
108regulation of gamma-delta T cell activation (GO:0046643)3.15099286
109indolalkylamine metabolic process (GO:0006586)3.14539339
110benzene-containing compound metabolic process (GO:0042537)3.14069366
111positive regulation of lipid catabolic process (GO:0050996)3.13412443
112positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12021372
1132-oxoglutarate metabolic process (GO:0006103)3.09856317
114drug metabolic process (GO:0017144)3.07183329
115regulation of cholesterol biosynthetic process (GO:0045540)3.06638370
116desmosome organization (GO:0002934)3.06376424
117amyloid precursor protein catabolic process (GO:0042987)3.05497832
118regulation of cholesterol metabolic process (GO:0090181)3.05317619
119ethanol metabolic process (GO:0006067)3.05034550
120arginine metabolic process (GO:0006525)3.04971794
121glucose 6-phosphate metabolic process (GO:0051156)3.04544552
122positive regulation of cellular amine metabolic process (GO:0033240)3.02786380
123amine catabolic process (GO:0009310)3.02569898
124regulation of extracellular matrix disassembly (GO:0010715)3.00230693
125positive regulation of gamma-delta T cell activation (GO:0046645)2.95398379
126detection of bacterium (GO:0016045)2.88700229
127epoxygenase P450 pathway (GO:0019373)2.88026325
128regulation of defense response to virus by virus (GO:0050690)2.80755407
129pentose-phosphate shunt (GO:0006098)2.79604343
130leukocyte aggregation (GO:0070486)2.79415386
131regulation of cellular extravasation (GO:0002691)2.76080025
132regulation of interleukin-13 production (GO:0032656)2.74203426
133positive regulation of interleukin-4 production (GO:0032753)2.72965947
134trophectodermal cell differentiation (GO:0001829)2.72199129
135positive thymic T cell selection (GO:0045059)2.71849426
136glutamine family amino acid biosynthetic process (GO:0009084)2.71084480
137T cell selection (GO:0045058)2.69999439
138negative T cell selection (GO:0043383)2.68199993
139negative thymic T cell selection (GO:0045060)2.67508547
140maintenance of gastrointestinal epithelium (GO:0030277)2.66407203
141detection of other organism (GO:0098543)2.66100389
142maternal placenta development (GO:0001893)2.64281555
143regulation of water loss via skin (GO:0033561)2.62527654
144positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61288703
145positive regulation of epidermal cell differentiation (GO:0045606)2.59498594
146multicellular organismal water homeostasis (GO:0050891)2.57932391
147glucose catabolic process (GO:0006007)2.56153396
148regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.54985067
149negative regulation of erythrocyte differentiation (GO:0045647)2.49014380
150amyloid precursor protein metabolic process (GO:0042982)2.48868920
151cellular zinc ion homeostasis (GO:0006882)2.47294019
152ear development (GO:0043583)2.46287292
153pentose metabolic process (GO:0019321)2.46204844
154negative regulation of cell size (GO:0045792)2.46108565
155antigen processing and presentation via MHC class Ib (GO:0002475)2.45631155
156NADPH regeneration (GO:0006740)2.42422472
157pinocytosis (GO:0006907)2.41729802
158embryonic process involved in female pregnancy (GO:0060136)2.40873705
159retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39596068
160cellular response to interleukin-4 (GO:0071353)2.37672339
161neutrophil activation involved in immune response (GO:0002283)2.37449698
162response to interleukin-15 (GO:0070672)2.37012623
163branching involved in mammary gland duct morphogenesis (GO:0060444)2.36027898
164epithelial cell differentiation involved in prostate gland development (GO:0060742)2.35575338
165intracellular estrogen receptor signaling pathway (GO:0030520)2.35502994
166regulation of mammary gland epithelial cell proliferation (GO:0033599)2.35469732
167fructose metabolic process (GO:0006000)2.34836233
168cellular response to interleukin-15 (GO:0071350)2.34464947
169negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.33722183
170positive regulation of T cell mediated cytotoxicity (GO:0001916)2.32319188
171vitamin transmembrane transport (GO:0035461)2.31948920
172Arp2/3 complex-mediated actin nucleation (GO:0034314)2.29872044
173regulation of extracellular matrix organization (GO:1903053)2.28972880
174modulation by symbiont of host defense response (GO:0052031)2.27829554
175modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.27829554
176positive regulation by organism of defense response of other organism involved in symbiotic interact2.27829554
177modulation by symbiont of host immune response (GO:0052553)2.27829554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.65313255
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.32715564
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.01331522
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.06431914
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.04800157
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.63212676
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.16820143
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.07733057
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.66898538
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.57133596
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.52041447
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.36276667
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30766099
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.26054610
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.15929312
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12483456
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09874850
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83687059
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75194019
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68567868
21* RUNX1_27514584_Chip-Seq_MCF-7_Human1.68186521
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67535024
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67140297
24* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65822154
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.63814140
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62709979
27MYC_22102868_ChIP-Seq_BL_Human1.59934112
28P68_20966046_ChIP-Seq_HELA_Human1.59865552
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57263651
30* TET1_21451524_ChIP-Seq_MESCs_Mouse1.53518810
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53020270
32* KDM2B_26808549_Chip-Seq_DND41_Human1.52916777
33* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52146592
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.49871048
35* CLOCK_20551151_ChIP-Seq_293T_Human1.46335996
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44482247
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43849543
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.43474060
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41929562
40VDR_21846776_ChIP-Seq_THP-1_Human1.41209870
41E2F7_22180533_ChIP-Seq_HELA_Human1.40952897
42CDX2_20551321_ChIP-Seq_CACO-2_Human1.40636055
43GATA1_22025678_ChIP-Seq_K562_Human1.40337826
44MAF_26560356_Chip-Seq_TH1_Human1.39339369
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38408351
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37978884
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.37056502
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35389392
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35135751
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.33970704
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33325822
52* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32096873
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31526998
54GATA4_25053715_ChIP-Seq_YYC3_Human1.31372515
55* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30375405
56SMC4_20622854_ChIP-Seq_HELA_Human1.26557688
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25273653
58GATA6_25053715_ChIP-Seq_YYC3_Human1.24580285
59* LXR_22292898_ChIP-Seq_THP-1_Human1.23889934
60* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23010369
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21668562
62* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19081682
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18350685
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.18299465
65* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18046415
66AR_21909140_ChIP-Seq_LNCAP_Human1.17654562
67* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16904967
68RACK7_27058665_Chip-Seq_MCF-7_Human1.16780896
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15851920
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15043134
71UTX_26944678_Chip-Seq_JUKART_Human1.14815030
72SCL_19346495_ChIP-Seq_HPC-7_Human1.14705437
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14430122
74* CREB1_26743006_Chip-Seq_LNCaP_Human1.13777308
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13559217
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12391169
77* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12144280
78* CTCF_26484167_Chip-Seq_Bcells_Mouse1.11808200
79MYB_26560356_Chip-Seq_TH1_Human1.11042199
80* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11024188
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.10862350
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10060551
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.09320163
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08291482
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.07993104
86MYB_26560356_Chip-Seq_TH2_Human1.07687761
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06553675
88TCF7_22412390_ChIP-Seq_EML_Mouse1.06334210
89* ETS1_21867929_ChIP-Seq_TH2_Mouse1.05677141
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04637661
91NCOR1_26117541_ChIP-Seq_K562_Human1.03958456
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03925711
93* HNF4A_19822575_ChIP-Seq_HepG2_Human1.03727036
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03497569
95SA1_27219007_Chip-Seq_Bcells_Human1.02448876
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01897085
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01792551
98* ELK3_25401928_ChIP-Seq_HUVEC_Human1.01642721
99E2F1_20622854_ChIP-Seq_HELA_Human1.01489406
100* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00898825
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00894975
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00627016
103* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00167515
104STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98879127
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97052201
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95789871
107SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95358847
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95027804
109ATF3_27146783_Chip-Seq_COLON_Human0.93239806
110MAF_26560356_Chip-Seq_TH2_Human0.91592281
111ESR2_21235772_ChIP-Seq_MCF-7_Human0.90875491
112VDR_24763502_ChIP-Seq_THP-1_Human0.90668965
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90177044
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88438154
115* FOXA2_19822575_ChIP-Seq_HepG2_Human0.88131660
116BCOR_27268052_Chip-Seq_Bcells_Human0.87828146
117* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87154657
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86585933
119ZNF263_19887448_ChIP-Seq_K562_Human0.86502956
120SPI1_23547873_ChIP-Seq_NB4_Human0.85688891
121BCL6_27268052_Chip-Seq_Bcells_Human0.85554554
122STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85314149
123* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84770733
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84097555
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83936813
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.83589406
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83173359
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.83138485
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82740117
130RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82443603
131Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82390045
132ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82367109
133FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.82316521
134* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82086247
135* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81470713
136FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80560819
137RUNX_20019798_ChIP-Seq_JUKART_Human0.79903628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.20070964
2MP0002139_abnormal_hepatobiliary_system5.94437587
3MP0005085_abnormal_gallbladder_physiolo4.37531131
4MP0005365_abnormal_bile_salt4.16991314
5MP0009840_abnormal_foam_cell3.91153188
6MP0008875_abnormal_xenobiotic_pharmacok3.87521315
7MP0001666_abnormal_nutrient_absorption3.09094739
8MP0003806_abnormal_nucleotide_metabolis3.03399103
9MP0003252_abnormal_bile_duct3.02451603
10MP0010329_abnormal_lipoprotein_level2.85443064
11MP0005332_abnormal_amino_acid2.47331487
12MP0004019_abnormal_vitamin_homeostasis2.42848638
13MP0003191_abnormal_cellular_cholesterol2.37362637
14MP0002138_abnormal_hepatobiliary_system1.92479497
15MP0010234_abnormal_vibrissa_follicle1.88541878
16MP0000609_abnormal_liver_physiology1.88467688
17MP0005083_abnormal_biliary_tract1.80487038
18MP0004381_abnormal_hair_follicle1.78618457
19* MP0009643_abnormal_urine_homeostasis1.64807425
20MP0008260_abnormal_autophagy1.63482768
21MP0002098_abnormal_vibrissa_morphology1.59420684
22MP0005319_abnormal_enzyme/_coenzyme1.55260914
23MP0005501_abnormal_skin_physiology1.53745727
24MP0003705_abnormal_hypodermis_morpholog1.53735188
25MP0002254_reproductive_system_inflammat1.53649884
26MP0003878_abnormal_ear_physiology1.53462567
27MP0005377_hearing/vestibular/ear_phenot1.53462567
28MP0002118_abnormal_lipid_homeostasis1.50874251
29MP0003436_decreased_susceptibility_to1.48991596
30MP0003300_gastrointestinal_ulcer1.48799272
31MP0002396_abnormal_hematopoietic_system1.43188013
32MP0003195_calcinosis1.41571877
33MP0004264_abnormal_extraembryonic_tissu1.41116017
34MP0005076_abnormal_cell_differentiation1.39440469
35MP0000678_abnormal_parathyroid_gland1.36792231
36MP0004782_abnormal_surfactant_physiolog1.34731533
37MP0000685_abnormal_immune_system1.33454224
38MP0000465_gastrointestinal_hemorrhage1.33425583
39MP0003186_abnormal_redox_activity1.32566463
40MP0005584_abnormal_enzyme/coenzyme_acti1.32363698
41MP0010155_abnormal_intestine_physiology1.29515438
42MP0003172_abnormal_lysosome_physiology1.29053096
43MP0001764_abnormal_homeostasis1.28495120
44MP0009785_altered_susceptibility_to1.26859726
45MP0005464_abnormal_platelet_physiology1.25891181
46MP0004947_skin_inflammation1.23638850
47MP0005075_abnormal_melanosome_morpholog1.22993698
48MP0008469_abnormal_protein_level1.22861321
49MP0009764_decreased_sensitivity_to1.21597846
50MP0010352_gastrointestinal_tract_polyps1.20954328
51MP0001835_abnormal_antigen_presentation1.20901838
52MP0004185_abnormal_adipocyte_glucose1.20235229
53MP0001873_stomach_inflammation1.19186737
54MP0009278_abnormal_bone_marrow1.15751891
55MP0005409_darkened_coat_color1.14480062
56MP0000598_abnormal_liver_morphology1.13184675
57MP0005025_abnormal_response_to1.13051425
58MP0000703_abnormal_thymus_morphology1.11801229
59MP0002089_abnormal_postnatal_growth/wei1.10401013
60MP0002136_abnormal_kidney_physiology1.10229536
61MP0001664_abnormal_digestion1.09022685
62MP0003866_abnormal_defecation1.07499775
63MP0001853_heart_inflammation1.05968459
64* MP0001765_abnormal_ion_homeostasis1.04200941
65MP0001845_abnormal_inflammatory_respons1.03591959
66MP0003868_abnormal_feces_composition1.03473636
67MP0000627_abnormal_mammary_gland1.03460322
68MP0006082_CNS_inflammation1.02027808
69MP0005451_abnormal_body_composition1.00882076
70MP0001800_abnormal_humoral_immune0.99594249
71MP0005058_abnormal_lysosome_morphology0.99427844
72MP0003763_abnormal_thymus_physiology0.99055936
73* MP0005636_abnormal_mineral_homeostasis0.98943437
74MP0004858_abnormal_nervous_system0.96926587
75MP0000604_amyloidosis0.95203025
76MP0009763_increased_sensitivity_to0.94434725
77MP0002419_abnormal_innate_immunity0.91908678
78MP0005387_immune_system_phenotype0.91851617
79MP0001790_abnormal_immune_system0.91851617
80MP0001849_ear_inflammation0.90929785
81MP0000462_abnormal_digestive_system0.90659123
82MP0003724_increased_susceptibility_to0.89769537
83MP0003656_abnormal_erythrocyte_physiolo0.88662787
84MP0005671_abnormal_response_to0.87270779
85MP0005084_abnormal_gallbladder_morpholo0.85840150
86* MP0003638_abnormal_response/metabolism_0.85796382
87MP0002166_altered_tumor_susceptibility0.85590088
88MP0003303_peritoneal_inflammation0.85018856
89MP0002723_abnormal_immune_serum0.84780596
90MP0002452_abnormal_antigen_presenting0.84303506
91MP0005000_abnormal_immune_tolerance0.83491746
92MP0009765_abnormal_xenobiotic_induced0.83471674
93MP0003183_abnormal_peptide_metabolism0.83370874
94MP0002796_impaired_skin_barrier0.81903826
95MP0010678_abnormal_skin_adnexa0.81380566
96MP0005310_abnormal_salivary_gland0.81357795
97* MP0009642_abnormal_blood_homeostasis0.81336431
98MP0001756_abnormal_urination0.81290025
99MP0001216_abnormal_epidermal_layer0.81118007
100MP0009379_abnormal_foot_pigmentation0.80819175
101MP0005166_decreased_susceptibility_to0.80572457
102MP0000566_synostosis0.80544966
103MP0009931_abnormal_skin_appearance0.80160145
104MP0005666_abnormal_adipose_tissue0.80048375
105MP0001819_abnormal_immune_cell0.77363945
106MP0001663_abnormal_digestive_system0.77093231
107MP0002420_abnormal_adaptive_immunity0.76476165
108MP0000490_abnormal_crypts_of0.76140770
109MP0003453_abnormal_keratinocyte_physiol0.75585585
110MP0009333_abnormal_splenocyte_physiolog0.75007472
111MP0000689_abnormal_spleen_morphology0.74471589
112MP0005023_abnormal_wound_healing0.72653845
113MP0002722_abnormal_immune_system0.72350696
114* MP0000477_abnormal_intestine_morphology0.71558030
115MP0000716_abnormal_immune_system0.69663486
116MP0002405_respiratory_system_inflammati0.69326896
117MP0003075_altered_response_to0.67187214
118MP0003011_delayed_dark_adaptation0.66894917
119MP0002398_abnormal_bone_marrow0.66586220
120MP0002148_abnormal_hypersensitivity_rea0.66345551
121MP0002429_abnormal_blood_cell0.64105465
122MP0000858_altered_metastatic_potential0.63580108
123MP0009697_abnormal_copulation0.62072815
124MP0002006_tumorigenesis0.61953237
125MP0002132_abnormal_respiratory_system0.61758082
126MP0009053_abnormal_anal_canal0.60172778
127MP0008873_increased_physiological_sensi0.60090739
128MP0001533_abnormal_skeleton_physiology0.58922004
129MP0005376_homeostasis/metabolism_phenot0.58783229
130MP0005381_digestive/alimentary_phenotyp0.58565721
131MP0004043_abnormal_pH_regulation0.57936251
132MP0001881_abnormal_mammary_gland0.57157882

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)5.42221748
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.35197127
3Intrahepatic cholestasis (HP:0001406)5.18568144
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.12830025
5Xanthomatosis (HP:0000991)5.08366330
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.95099458
7Deep venous thrombosis (HP:0002625)4.73300091
8Hyperglycinuria (HP:0003108)4.17269872
9Hyperammonemia (HP:0001987)3.92389557
10Abnormality of sulfur amino acid metabolism (HP:0004339)3.81794200
11Hypolipoproteinemia (HP:0010981)3.81686309
12Prolonged partial thromboplastin time (HP:0003645)3.69947446
13Abnormality of serine family amino acid metabolism (HP:0010894)3.68262516
14Abnormality of glycine metabolism (HP:0010895)3.68262516
15Fat malabsorption (HP:0002630)3.59963403
16Hyperlipoproteinemia (HP:0010980)3.59337946
17Abnormality of aspartate family amino acid metabolism (HP:0010899)3.54691708
18Complement deficiency (HP:0004431)3.38776006
19Abnormality of pyrimidine metabolism (HP:0004353)3.37659242
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.36119740
21Abnormality of nucleobase metabolism (HP:0010932)3.14942463
22Ketosis (HP:0001946)3.14935885
23Abnormality of the common coagulation pathway (HP:0010990)3.14625323
24Joint hemorrhage (HP:0005261)3.13186313
25Hyperglycinemia (HP:0002154)3.12024622
26Epidermoid cyst (HP:0200040)3.08995284
27Hydroxyprolinuria (HP:0003080)3.07920436
28Abnormality of proline metabolism (HP:0010907)3.07920436
29Hypercholesterolemia (HP:0003124)3.05989624
30Malnutrition (HP:0004395)3.05789702
31Abnormality of macrophages (HP:0004311)3.04399738
32Abnormality of purine metabolism (HP:0004352)3.03584074
33Myositis (HP:0100614)3.00054517
34Conjugated hyperbilirubinemia (HP:0002908)2.98272193
35Autoimmune thrombocytopenia (HP:0001973)2.97373529
36Acanthocytosis (HP:0001927)2.90992790
37Hypoalphalipoproteinemia (HP:0003233)2.86747127
38Abnormality of fatty-acid metabolism (HP:0004359)2.86653126
39Hypoglycemic coma (HP:0001325)2.84724863
40Flat acetabular roof (HP:0003180)2.82951739
41Recurrent abscess formation (HP:0002722)2.77741524
42Gout (HP:0001997)2.74833577
43Micronodular cirrhosis (HP:0001413)2.72437117
44J-shaped sella turcica (HP:0002680)2.72095517
45Distal lower limb muscle weakness (HP:0009053)2.70347547
46Thin bony cortex (HP:0002753)2.70177459
47Esophageal varix (HP:0002040)2.68784007
48Abnormality of complement system (HP:0005339)2.65537301
49Growth hormone excess (HP:0000845)2.65145439
50Hyperbilirubinemia (HP:0002904)2.64868451
51Orchitis (HP:0100796)2.64766703
52Increased IgE level (HP:0003212)2.64141072
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.64013721
54Abnormality of methionine metabolism (HP:0010901)2.63251173
55Systemic lupus erythematosus (HP:0002725)2.61407282
56Recurrent gram-negative bacterial infections (HP:0005420)2.60148068
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.59947119
58Myocardial infarction (HP:0001658)2.54843048
59Late onset (HP:0003584)2.54637544
60Spastic diplegia (HP:0001264)2.53818791
61Delayed CNS myelination (HP:0002188)2.49514201
62Vascular calcification (HP:0004934)2.45163205
63Asymmetry of the thorax (HP:0001555)2.44397423
64Widely patent fontanelles and sutures (HP:0004492)2.44062506
65Hypochromic anemia (HP:0001931)2.43656439
66Septate vagina (HP:0001153)2.43092551
67Seborrheic dermatitis (HP:0001051)2.42275546
68Metabolic acidosis (HP:0001942)2.41502880
69Increased cerebral lipofuscin (HP:0011813)2.41286405
70Steatorrhea (HP:0002570)2.39594908
71Gastrointestinal infarctions (HP:0005244)2.39042208
72Chronic obstructive pulmonary disease (HP:0006510)2.38212453
73Obstructive lung disease (HP:0006536)2.38212453
74Gastrointestinal inflammation (HP:0004386)2.36645460
75Ketoacidosis (HP:0001993)2.36203475
76Ileus (HP:0002595)2.35525469
77Purpura (HP:0000979)2.34159530
78Hepatocellular carcinoma (HP:0001402)2.30700727
79Meningitis (HP:0001287)2.30459050
80Recurrent bacterial skin infections (HP:0005406)2.29520247
81Gingival bleeding (HP:0000225)2.27912397
82Proximal tubulopathy (HP:0000114)2.26719669
83Right ventricular cardiomyopathy (HP:0011663)2.26166328
84Autoimmune hemolytic anemia (HP:0001890)2.24256460
85Pustule (HP:0200039)2.23050000
86Dicarboxylic aciduria (HP:0003215)2.22068700
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22068700
88Abnormality of the intrinsic pathway (HP:0010989)2.21667410
89Prolonged bleeding time (HP:0003010)2.16467552
90Hyperparathyroidism (HP:0000843)2.16216570
91Mucopolysacchariduria (HP:0008155)2.15615605
92Urinary glycosaminoglycan excretion (HP:0003541)2.15615605
93Vacuolated lymphocytes (HP:0001922)2.14851985
94Generalized aminoaciduria (HP:0002909)2.14441056
95Pancreatitis (HP:0001733)2.12789012
96Dysostosis multiplex (HP:0000943)2.12595576
97Alkalosis (HP:0001948)2.12265254
98Petechiae (HP:0000967)2.12144353
99Increased IgM level (HP:0003496)2.10783220
100Sensorimotor neuropathy (HP:0007141)2.09151961
101Abnormality of transition element cation homeostasis (HP:0011030)2.08869643
102Increased mean platelet volume (HP:0011877)2.07780429
103Cardiovascular calcification (HP:0011915)2.06582195
104Abnormal platelet volume (HP:0011876)2.06300131
105Optic neuritis (HP:0100653)2.05726576
106Retrobulbar optic neuritis (HP:0100654)2.05726576
107Poikilocytosis (HP:0004447)2.05657252
108Urticaria (HP:0001025)2.05605699
109Inflammation of the large intestine (HP:0002037)2.05557353
110Polygenic inheritance (HP:0010982)2.04990656
111Stomatitis (HP:0010280)2.04840635
112Granulocytopenia (HP:0001913)2.04569732
113Abnormal delayed hypersensitivity skin test (HP:0002963)2.04545503
114Recurrent fungal infections (HP:0002841)2.04457880
115Abnormality of serum amino acid levels (HP:0003112)2.03448263
116Pili torti (HP:0003777)2.03408781
117Vasculitis (HP:0002633)2.03101800
118Irritability (HP:0000737)2.02842461
119Chronic diarrhea (HP:0002028)2.01881737
120Abnormal platelet function (HP:0011869)2.01756499
121Impaired platelet aggregation (HP:0003540)2.01756499
122Sparse lateral eyebrow (HP:0005338)2.01371450
123Nausea (HP:0002018)2.01047607
124Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99614238
125Abnormality of polysaccharide metabolism (HP:0011012)1.99614238
126Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99614238
127Cellulitis (HP:0100658)1.99576932
128Encephalitis (HP:0002383)1.99422917
129Abnormal enzyme/coenzyme activity (HP:0012379)1.99335427
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99138568
131Joint swelling (HP:0001386)1.98114225
132Lethargy (HP:0001254)1.97749399
133Amyloidosis (HP:0011034)1.96385996
134Mediastinal lymphadenopathy (HP:0100721)1.94563140
135Amelogenesis imperfecta (HP:0000705)1.94071265
136Abnormality of iron homeostasis (HP:0011031)1.93768704
137Abnormal cartilage morphology (HP:0002763)1.93290767
138Wide cranial sutures (HP:0010537)1.92716269
139Acute hepatic failure (HP:0006554)1.92585228
140Glycosuria (HP:0003076)1.91020276
141Abnormality of urine glucose concentration (HP:0011016)1.91020276
142Eczematoid dermatitis (HP:0000976)1.90683437
143Easy fatigability (HP:0003388)1.90141440
144Thrombophlebitis (HP:0004418)1.89339879
145Menorrhagia (HP:0000132)1.89322010
146Nasal polyposis (HP:0100582)1.89210573
147Increased purine levels (HP:0004368)1.89078468
148Hyperuricemia (HP:0002149)1.89078468
149Epistaxis (HP:0000421)1.88309624
150Abnormality of small intestinal villus morphology (HP:0011472)1.86820756
151Villous atrophy (HP:0011473)1.86820756
152Colitis (HP:0002583)1.86713842
153* Nephrolithiasis (HP:0000787)1.86555460
154Polycythemia (HP:0001901)1.86231297
155Arterial thrombosis (HP:0004420)1.83718810
156Gingivitis (HP:0000230)1.82559978
157Increased serum ferritin (HP:0003281)1.82087422
158Gastrointestinal dysmotility (HP:0002579)1.81057150
159Abnormality of alkaline phosphatase activity (HP:0004379)1.81050987
160Testicular neoplasm (HP:0010788)1.80241612
161Combined immunodeficiency (HP:0005387)1.79882197
162Abnormality of T cells (HP:0002843)1.79774557
163Bone pain (HP:0002653)1.79531334
164Hemorrhage of the eye (HP:0011885)1.79092687
165Megaloblastic anemia (HP:0001889)1.78878755
166Confusion (HP:0001289)1.78799647
167Abdominal distention (HP:0003270)1.78322743
168Glomerulonephritis (HP:0000099)1.78109118
169Neonatal onset (HP:0003623)1.77468743
170Elevated erythrocyte sedimentation rate (HP:0003565)1.77420575
171Abnormal tarsal ossification (HP:0008369)1.76651627
172Concave nail (HP:0001598)1.73009888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.78842212
2BCKDK3.32530800
3MAP4K13.06902086
4FGFR43.02279261
5SMG12.83595296
6MAP3K102.69046288
7MST42.65908422
8TRIB32.58063161
9STK102.48472615
10TAOK32.40687086
11TYK22.27465259
12PKN22.19681275
13SIK12.19015063
14TBK12.09660988
15PTK62.02662987
16RIPK41.96882445
17MST1R1.83170736
18LRRK21.77910537
19PRPF4B1.76641289
20TESK21.69531337
21JAK31.65315445
22EPHA21.64169756
23EEF2K1.61482460
24ZAP701.59120226
25MUSK1.52407207
26FLT31.50146504
27KDR1.49922307
28MAP3K141.49538921
29EPHB11.49146713
30RIPK11.48505731
31IKBKE1.41698953
32MAP2K31.37119932
33BTK1.36778823
34BLK1.36246307
35IRAK31.33108696
36MAPK111.31349072
37TNK21.28835292
38VRK21.28723786
39FRK1.26656628
40TXK1.23884389
41MAP3K111.23815459
42MAP2K21.22839340
43ITK1.22177268
44NLK1.20950354
45NME21.20662476
46PIK3CA1.18644017
47KIT1.17745282
48CSK1.14524722
49PRKG21.14518595
50SIK31.14232299
51ICK1.13019711
52JAK11.12042131
53MAP3K31.09811021
54MAP3K81.09690966
55SCYL21.07823924
56PAK41.05120414
57LMTK21.04386643
58JAK20.99247518
59PDPK10.96444002
60TAOK20.96316259
61PIM10.94613393
62CDK40.93749338
63RPS6KA40.89823785
64TAOK10.89007154
65NEK60.86431617
66MAP3K70.85946509
67RET0.83858846
68PTK20.83550322
69CDK60.83520262
70FGFR30.82764045
71PDK10.80730189
72RPS6KB20.73672759
73ERBB40.72801413
74CSF1R0.72211891
75MAP2K60.70509596
76IKBKB0.69015586
77MATK0.68657037
78PRKD20.67553256
79LCK0.66909906
80CHUK0.66453965
81MAPKAPK20.66404675
82TGFBR20.65705308
83FES0.65648945
84BMX0.64772470
85NEK90.62725980
86TEC0.62430752
87NEK20.61945394
88TESK10.61469241
89RPS6KA20.59751882
90HIPK20.59099371
91SYK0.57541000
92NME10.56532772
93CDK120.56408678
94IRAK40.54440216
95MAP3K120.54200026
96STK40.52585594
97MAP3K130.52458296
98MAP2K10.50229443
99ABL20.49639289
100DYRK1B0.49393870
101RPS6KC10.48447448
102RPS6KL10.48447448
103LYN0.48407582
104HCK0.48000135
105CAMKK10.47902862
106MAPK40.46392294
107KSR20.46132981
108PRKAA20.45787363
109IRAK20.43910713
110ACVR1B0.43712014
111PRKCQ0.42391622
112MAP3K20.42193099
113MARK30.41734390
114TLK10.41196300
115DAPK10.40196642
116ERBB20.39749286
117MARK20.39092854
118MTOR0.37490644
119TGFBR10.37000307
120MAPKAPK30.35738177
121ILK0.34697371
122PIM20.32847749
123NEK10.30883325
124* GRK60.30566714
125CDK70.29516255
126MAP3K10.28949045
127MELK0.28730577
128EIF2AK10.28124786
129EGFR0.27938842
130PRKCI0.27667795
131MET0.27076018
132GSK3A0.26584851

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.43244985
2Nitrogen metabolism_Homo sapiens_hsa009103.41617716
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.35647091
4Arginine biosynthesis_Homo sapiens_hsa002202.62182515
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49989126
6Caffeine metabolism_Homo sapiens_hsa002322.44097670
7Tryptophan metabolism_Homo sapiens_hsa003802.42230383
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41846229
9Fatty acid degradation_Homo sapiens_hsa000712.35280317
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.32507636
11Fat digestion and absorption_Homo sapiens_hsa049752.16260156
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13202526
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98168329
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.96474866
15Histidine metabolism_Homo sapiens_hsa003401.93728860
16Complement and coagulation cascades_Homo sapiens_hsa046101.92525626
17Peroxisome_Homo sapiens_hsa041461.85946426
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83542217
19Vitamin digestion and absorption_Homo sapiens_hsa049771.80095153
20PPAR signaling pathway_Homo sapiens_hsa033201.80038321
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.77732286
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.76305329
23Folate biosynthesis_Homo sapiens_hsa007901.66598226
24Bile secretion_Homo sapiens_hsa049761.65670868
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64036010
26Chemical carcinogenesis_Homo sapiens_hsa052041.63375136
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62665001
28Selenocompound metabolism_Homo sapiens_hsa004501.61206180
29Starch and sucrose metabolism_Homo sapiens_hsa005001.55328128
30Staphylococcus aureus infection_Homo sapiens_hsa051501.54382436
31Butanoate metabolism_Homo sapiens_hsa006501.53893467
32beta-Alanine metabolism_Homo sapiens_hsa004101.53776886
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51596396
34Sulfur metabolism_Homo sapiens_hsa009201.49514997
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49077254
36Propanoate metabolism_Homo sapiens_hsa006401.48753666
37B cell receptor signaling pathway_Homo sapiens_hsa046621.47640635
38T cell receptor signaling pathway_Homo sapiens_hsa046601.46426990
39Fatty acid metabolism_Homo sapiens_hsa012121.45612425
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40819201
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39397113
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38722510
43Non-small cell lung cancer_Homo sapiens_hsa052231.35313040
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.33245721
45Biosynthesis of amino acids_Homo sapiens_hsa012301.30368726
46Retinol metabolism_Homo sapiens_hsa008301.29181446
47Thyroid cancer_Homo sapiens_hsa052161.28795990
48Sulfur relay system_Homo sapiens_hsa041221.26832900
49Pyruvate metabolism_Homo sapiens_hsa006201.26284716
50Carbon metabolism_Homo sapiens_hsa012001.24897252
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.19688941
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15585439
53Renin-angiotensin system_Homo sapiens_hsa046141.12742728
54Glutathione metabolism_Homo sapiens_hsa004801.12104039
55Pentose phosphate pathway_Homo sapiens_hsa000301.11852251
56Phenylalanine metabolism_Homo sapiens_hsa003601.11797444
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06609004
58ABC transporters_Homo sapiens_hsa020101.06436436
59Graft-versus-host disease_Homo sapiens_hsa053321.03962598
60Galactose metabolism_Homo sapiens_hsa000521.02890775
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00087081
62Arginine and proline metabolism_Homo sapiens_hsa003300.97839574
63Chronic myeloid leukemia_Homo sapiens_hsa052200.96991259
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95738011
65VEGF signaling pathway_Homo sapiens_hsa043700.94221175
66Endometrial cancer_Homo sapiens_hsa052130.93934069
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.93145342
68Osteoclast differentiation_Homo sapiens_hsa043800.91803265
69Allograft rejection_Homo sapiens_hsa053300.91717974
70One carbon pool by folate_Homo sapiens_hsa006700.91162893
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89674091
72Glycerolipid metabolism_Homo sapiens_hsa005610.89419237
73Steroid biosynthesis_Homo sapiens_hsa001000.89241154
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.86226264
75Autoimmune thyroid disease_Homo sapiens_hsa053200.84504071
76Fructose and mannose metabolism_Homo sapiens_hsa000510.83828109
77Tyrosine metabolism_Homo sapiens_hsa003500.80543798
78Mineral absorption_Homo sapiens_hsa049780.80531939
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79298152
80Lysine degradation_Homo sapiens_hsa003100.79167268
81Endocytosis_Homo sapiens_hsa041440.78154522
82Pancreatic cancer_Homo sapiens_hsa052120.77764336
83Notch signaling pathway_Homo sapiens_hsa043300.77650848
84Lysosome_Homo sapiens_hsa041420.72428359
85N-Glycan biosynthesis_Homo sapiens_hsa005100.71318089
86Prolactin signaling pathway_Homo sapiens_hsa049170.68537518
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68033716
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65374381
89Hepatitis B_Homo sapiens_hsa051610.64988958
90Arachidonic acid metabolism_Homo sapiens_hsa005900.63149649
91Chemokine signaling pathway_Homo sapiens_hsa040620.62541089
92Insulin signaling pathway_Homo sapiens_hsa049100.62207690
93Tuberculosis_Homo sapiens_hsa051520.59675839
94Primary immunodeficiency_Homo sapiens_hsa053400.59417831
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58427675
96Shigellosis_Homo sapiens_hsa051310.56834055
97Sphingolipid metabolism_Homo sapiens_hsa006000.55712940
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53973017
99Bladder cancer_Homo sapiens_hsa052190.53757005
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53753961
101Choline metabolism in cancer_Homo sapiens_hsa052310.53403733
102Inositol phosphate metabolism_Homo sapiens_hsa005620.52451248
103AMPK signaling pathway_Homo sapiens_hsa041520.52021771
104Vibrio cholerae infection_Homo sapiens_hsa051100.51854023
105TNF signaling pathway_Homo sapiens_hsa046680.51303873
106Fatty acid biosynthesis_Homo sapiens_hsa000610.47511558
107Fatty acid elongation_Homo sapiens_hsa000620.47437590
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46651276
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.42284223
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39081662
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37404760
112Metabolic pathways_Homo sapiens_hsa011000.35275192
113Leishmaniasis_Homo sapiens_hsa051400.31270979
114Legionellosis_Homo sapiens_hsa051340.31100757
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30201738
116Insulin resistance_Homo sapiens_hsa049310.30117754
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.29150416
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.28478120
119Other glycan degradation_Homo sapiens_hsa005110.28403311
120Hepatitis C_Homo sapiens_hsa051600.24881588
121Antigen processing and presentation_Homo sapiens_hsa046120.23050272
122Protein digestion and absorption_Homo sapiens_hsa049740.20867777
123Measles_Homo sapiens_hsa051620.18593862
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14840434
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.14550787
126Influenza A_Homo sapiens_hsa051640.12740040
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12625376
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.12025831
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.11941889
130Pertussis_Homo sapiens_hsa051330.11595570
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.11361197
132Vitamin B6 metabolism_Homo sapiens_hsa007500.10800192
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.10719219
134Hematopoietic cell lineage_Homo sapiens_hsa046400.09426434
135Acute myeloid leukemia_Homo sapiens_hsa052210.09359695
136Herpes simplex infection_Homo sapiens_hsa051680.08600115
137Apoptosis_Homo sapiens_hsa042100.06875238

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