SLC9A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoskeletal anchoring at plasma membrane (GO:0007016)3.88521645
2positive regulation of histone deacetylation (GO:0031065)3.67326031
3skin morphogenesis (GO:0043589)3.65271796
4hemidesmosome assembly (GO:0031581)3.57369349
5regulation of ARF protein signal transduction (GO:0032012)3.47460464
6positive regulation of Cdc42 GTPase activity (GO:0043089)3.37860566
7regulation of water loss via skin (GO:0033561)3.17300832
8COPI coating of Golgi vesicle (GO:0048205)3.14387885
9Golgi transport vesicle coating (GO:0048200)3.14387885
10basement membrane organization (GO:0071711)3.12542094
11cell-substrate junction assembly (GO:0007044)3.12417970
12positive regulation of receptor recycling (GO:0001921)3.08267679
13negative regulation of erythrocyte differentiation (GO:0045647)2.97480165
14planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96968676
15cytoplasmic mRNA processing body assembly (GO:0033962)2.95911502
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87727780
17regulation of p38MAPK cascade (GO:1900744)2.85944073
18* sodium ion export (GO:0071436)2.85894869
19vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.85262445
20protein retention in ER lumen (GO:0006621)2.82989827
21surfactant homeostasis (GO:0043129)2.82877372
22bundle of His cell to Purkinje myocyte communication (GO:0086069)2.82498729
23activation of Rac GTPase activity (GO:0032863)2.79805790
24endothelial cell chemotaxis (GO:0035767)2.79392811
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76599538
26regulation of apoptotic process involved in morphogenesis (GO:1902337)2.75883071
27hypotonic response (GO:0006971)2.75529555
28dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.73645683
29branching involved in mammary gland duct morphogenesis (GO:0060444)2.73379500
30regulation of clathrin-mediated endocytosis (GO:2000369)2.72845644
31negative regulation of cell size (GO:0045792)2.69642986
32semaphorin-plexin signaling pathway (GO:0071526)2.69627200
33regulation of ARF GTPase activity (GO:0032312)2.69579798
34atrioventricular valve morphogenesis (GO:0003181)2.68030963
35regulation of T-helper 2 cell differentiation (GO:0045628)2.67918027
36regulation of NFAT protein import into nucleus (GO:0051532)2.67216426
37protein localization to endosome (GO:0036010)2.66606382
38positive regulation of fibroblast migration (GO:0010763)2.64505035
39plasma membrane repair (GO:0001778)2.62130242
40regulation of extracellular matrix disassembly (GO:0010715)2.60602381
41insulin-like growth factor receptor signaling pathway (GO:0048009)2.59712859
42regulation of early endosome to late endosome transport (GO:2000641)2.59094860
43stress fiber assembly (GO:0043149)2.58808780
44membrane protein ectodomain proteolysis (GO:0006509)2.57605419
45establishment of skin barrier (GO:0061436)2.55526018
46negative regulation of adherens junction organization (GO:1903392)2.52632283
47negative regulation of focal adhesion assembly (GO:0051895)2.52632283
48negative regulation of cell junction assembly (GO:1901889)2.52632283
49cell-cell junction maintenance (GO:0045217)2.50313849
50adherens junction assembly (GO:0034333)2.49984199
51peptidyl-tyrosine autophosphorylation (GO:0038083)2.47918856
52decidualization (GO:0046697)2.47838435
53negative regulation of homotypic cell-cell adhesion (GO:0034111)2.47725281
54response to laminar fluid shear stress (GO:0034616)2.45667901
55platelet formation (GO:0030220)2.45323087
56modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.43539857
57positive regulation by organism of defense response of other organism involved in symbiotic interact2.43539857
58modulation by symbiont of host immune response (GO:0052553)2.43539857
59positive regulation by symbiont of host defense response (GO:0052509)2.43539857
60modulation by symbiont of host defense response (GO:0052031)2.43539857
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.43539857
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.42086415
63antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.42086415
64cortical actin cytoskeleton organization (GO:0030866)2.40584818
65megakaryocyte development (GO:0035855)2.40280234
66positive regulation of protein deacetylation (GO:0090312)2.38683089
67pinocytosis (GO:0006907)2.37785348
68protein targeting to plasma membrane (GO:0072661)2.37560457
69antigen processing and presentation of endogenous antigen (GO:0019883)2.37108052
70focal adhesion assembly (GO:0048041)2.36951222
71cell-substrate adherens junction assembly (GO:0007045)2.36951222
72retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.36703214
73regulation of integrin activation (GO:0033623)2.36445916
74receptor catabolic process (GO:0032801)2.36323891
75regulation of interleukin-12 biosynthetic process (GO:0045075)2.35532449
76apoptotic cell clearance (GO:0043277)2.35392954
77positive regulation of p38MAPK cascade (GO:1900745)2.35128172
78regulation of transforming growth factor beta1 production (GO:0032908)2.34769098
79barbed-end actin filament capping (GO:0051016)2.34467959
80mesodermal cell differentiation (GO:0048333)2.34253526
81negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.33293846
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.32942402
83negative regulation of cell killing (GO:0031342)2.32942402
84regulation of macrophage cytokine production (GO:0010935)2.32792674
85regulation of erythrocyte differentiation (GO:0045646)2.32038470
86mammary gland epithelial cell proliferation (GO:0033598)2.31911859
87desmosome organization (GO:0002934)2.31772536
88renal filtration (GO:0097205)2.31408914
89regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.30481008
90positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.29389515
91negative regulation of viral release from host cell (GO:1902187)2.29202716
92epithelial cell-cell adhesion (GO:0090136)2.28223086
93maternal placenta development (GO:0001893)2.28067965
94endocytic recycling (GO:0032456)2.27730739
95substrate-dependent cell migration (GO:0006929)2.27620715
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.26928401
97positive regulation of keratinocyte differentiation (GO:0045618)2.25617433
98ear development (GO:0043583)2.25452993
99embryonic hemopoiesis (GO:0035162)2.23716384
100NLS-bearing protein import into nucleus (GO:0006607)2.23540505
101wound healing, spreading of epidermal cells (GO:0035313)2.23025231
102negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.22939305
103signal complex assembly (GO:0007172)2.22233899
104JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.22129422
105cellular potassium ion homeostasis (GO:0030007)2.21807097
106thymic T cell selection (GO:0045061)2.21650878
107negative regulation of nucleotide catabolic process (GO:0030812)2.20875079
108activation of JUN kinase activity (GO:0007257)2.19572975
109cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.19443583
110endodermal cell differentiation (GO:0035987)2.19015678
111modulation by symbiont of host cellular process (GO:0044068)2.18315358
112embryonic process involved in female pregnancy (GO:0060136)2.18146106
113multicellular organismal water homeostasis (GO:0050891)2.18007320
114synaptic vesicle maturation (GO:0016188)2.16957627
115negative regulation of fatty acid transport (GO:2000192)2.16940702
116growth hormone receptor signaling pathway (GO:0060396)2.16423870
117extracellular matrix disassembly (GO:0022617)2.16423529
118cell junction assembly (GO:0034329)2.15632312
119positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.14531760
120positive regulation of gamma-delta T cell activation (GO:0046645)2.14510713
121cell volume homeostasis (GO:0006884)2.14407731
122peptidyl-proline hydroxylation (GO:0019511)2.14134593
123wound healing, spreading of cells (GO:0044319)2.14124521
124endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.13532805
125regulation of endothelial cell chemotaxis (GO:2001026)2.12744845
126modulation by virus of host morphology or physiology (GO:0019048)2.12656923
127positive thymic T cell selection (GO:0045059)2.12337113
128cell junction organization (GO:0034330)2.12270495
129glucocorticoid receptor signaling pathway (GO:0042921)2.11125710
130negative regulation of keratinocyte proliferation (GO:0010839)2.10936858
131extracellular matrix assembly (GO:0085029)2.10661475
132mannose metabolic process (GO:0006013)2.10611393
133Rho protein signal transduction (GO:0007266)2.10513476
134cell adhesion mediated by integrin (GO:0033627)2.10416423
135actin filament bundle assembly (GO:0051017)2.10379758
136actin filament bundle organization (GO:0061572)2.10379758
137positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.09327723
138layer formation in cerebral cortex (GO:0021819)2.09044523
139response to fluid shear stress (GO:0034405)2.07038589
140actin filament capping (GO:0051693)2.06771451
141regulation of gamma-delta T cell differentiation (GO:0045586)2.05976982
142locomotory exploration behavior (GO:0035641)2.05962920
143heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.05085827
144cellular response to growth hormone stimulus (GO:0071378)2.04720416
145cell communication by electrical coupling (GO:0010644)2.04030586
146cortical cytoskeleton organization (GO:0030865)2.03969948
147regulation of histone deacetylation (GO:0031063)2.03266144
148apoptotic process involved in morphogenesis (GO:0060561)2.01998430
149negative regulation of stress fiber assembly (GO:0051497)2.01199041
150negative regulation of catenin import into nucleus (GO:0035414)2.00547079
151cellular response to vascular endothelial growth factor stimulus (GO:0035924)1.99801136
152substrate adhesion-dependent cell spreading (GO:0034446)1.99594887
153G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)1.99501498
154epithelial cell differentiation involved in prostate gland development (GO:0060742)1.98722216
155positive regulation of blood vessel endothelial cell migration (GO:0043536)1.98680299
156positive regulation of Rap GTPase activity (GO:0032854)1.98610918
157intracellular estrogen receptor signaling pathway (GO:0030520)1.98539049
158cell communication involved in cardiac conduction (GO:0086065)1.98084668
159cerebellar Purkinje cell differentiation (GO:0021702)1.95332057
160receptor recycling (GO:0001881)1.95273895
161vascular endothelial growth factor signaling pathway (GO:0038084)1.95179574
162protein heterotrimerization (GO:0070208)1.95091258

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.20883591
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.22183901
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.05361592
4* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.80570606
5KDM2B_26808549_Chip-Seq_DND41_Human2.53759674
6* MYC_22102868_ChIP-Seq_BL_Human2.45763905
7TCF7_22412390_ChIP-Seq_EML_Mouse2.40888467
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36419583
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.32551772
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26461740
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.24033391
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20406579
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.19044706
14VDR_21846776_ChIP-Seq_THP-1_Human2.16364201
15* KDM2B_26808549_Chip-Seq_K562_Human2.15906223
16LXR_22292898_ChIP-Seq_THP-1_Human2.08768775
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97110967
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95124185
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88703548
20KDM2B_26808549_Chip-Seq_JURKAT_Human1.88044412
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81948802
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80689742
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80369149
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.78424963
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69685139
26MAF_26560356_Chip-Seq_TH1_Human1.68977959
27* RACK7_27058665_Chip-Seq_MCF-7_Human1.67856147
28GATA1_19941826_ChIP-Seq_K562_Human1.67203446
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.63084245
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62272298
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57541525
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56463473
33* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.56122209
34* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.55903118
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55800983
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55269567
37GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52196135
38SCL_19346495_ChIP-Seq_HPC-7_Human1.49142720
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46543578
40* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45090482
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44310825
42SPI1_23127762_ChIP-Seq_K562_Human1.44176921
43VDR_24763502_ChIP-Seq_THP-1_Human1.44110334
44* GATA1_19941827_ChIP-Seq_MEL_Mouse1.42845954
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41448960
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40902926
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40557639
48* UTX_26944678_Chip-Seq_JUKART_Human1.40220409
49* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38778379
50* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38530005
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36784092
52DROSHA_22980978_ChIP-Seq_HELA_Human1.36405046
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35977452
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.34729923
55* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31519566
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.29561615
57* CREB1_26743006_Chip-Seq_LNCaP_Human1.28723854
58RUNX1_27514584_Chip-Seq_MCF-7_Human1.27400780
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26745019
60* UBF1/2_26484160_Chip-Seq_HMECs_Human1.25962737
61* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25277255
62ZNF263_19887448_ChIP-Seq_K562_Human1.24897636
63* ATF3_27146783_Chip-Seq_COLON_Human1.24690900
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24322699
65* NCOR1_26117541_ChIP-Seq_K562_Human1.24210045
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24203480
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24150607
68* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23752277
69* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23752277
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22354506
71* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21419113
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21379339
73* GATA2_21666600_ChIP-Seq_HMVEC_Human1.18969490
74* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18621197
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.18042829
76* GATA2_19941826_ChIP-Seq_K562_Human1.17531228
77* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17346066
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.17107929
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16716191
80* RARB_27405468_Chip-Seq_BRAIN_Mouse1.15426053
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14959768
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14302165
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13862698
84RUNX_20019798_ChIP-Seq_JUKART_Human1.12271699
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12069616
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10796750
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10726952
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10440565
89P68_20966046_ChIP-Seq_HELA_Human1.10309591
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09648484
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09179387
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08501520
93TP53_22127205_ChIP-Seq_IMR90_Human1.08411461
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.07744662
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07571363
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06686317
97GATA1_22025678_ChIP-Seq_K562_Human1.06539478
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05312463
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05191694
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05147451
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.04948117
102* TET1_21490601_ChIP-Seq_MESCs_Mouse1.04894800
103* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03309160
104KLF5_25053715_ChIP-Seq_YYC3_Human1.03256337
105SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02936926
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.02924768
107ESR1_21235772_ChIP-Seq_MCF-7_Human1.02835080
108BP1_19119308_ChIP-ChIP_Hs578T_Human1.02477158
109* TBX20_22328084_ChIP-Seq_HEART_Mouse1.02105846
110* TBX20_22080862_ChIP-Seq_HEART_Mouse1.02105846
111* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01438395
112CTCF_27219007_Chip-Seq_Bcells_Human1.01330229
113IRF8_27001747_Chip-Seq_BMDM_Mouse1.00863881
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99888494
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98511311
116SMC4_20622854_ChIP-Seq_HELA_Human0.98048232
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97881510
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97790692
119BCOR_27268052_Chip-Seq_Bcells_Human0.96814139
120* TP63_22573176_ChIP-Seq_HFKS_Human0.95997405
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95143821
122HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95087457
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94856149
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94651525
125* GATA6_25053715_ChIP-Seq_YYC3_Human0.93054204
126CLOCK_20551151_ChIP-Seq_293T_Human0.92645840
127MYB_26560356_Chip-Seq_TH2_Human0.92149796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.91175875
2MP0003300_gastrointestinal_ulcer3.18230917
3MP0008961_abnormal_basal_metabolism2.69153596
4MP0004510_myositis2.62248205
5MP0003566_abnormal_cell_adhesion2.58580242
6MP0005076_abnormal_cell_differentiation2.49769774
7MP0005409_darkened_coat_color2.48059811
8MP0004859_abnormal_synaptic_plasticity2.37392268
9MP0010352_gastrointestinal_tract_polyps2.31420644
10MP0003303_peritoneal_inflammation2.22783004
11MP0000579_abnormal_nail_morphology2.20443728
12MP0010234_abnormal_vibrissa_follicle2.16355391
13MP0008260_abnormal_autophagy2.13333360
14MP0005451_abnormal_body_composition2.10077259
15MP0003191_abnormal_cellular_cholesterol2.04848366
16MP0009278_abnormal_bone_marrow1.99119260
17MP0005257_abnormal_intraocular_pressure1.95551305
18MP0005275_abnormal_skin_tensile1.90002213
19MP0000678_abnormal_parathyroid_gland1.86004603
20MP0003172_abnormal_lysosome_physiology1.86001860
21MP0008438_abnormal_cutaneous_collagen1.85933381
22MP0002254_reproductive_system_inflammat1.82975342
23MP0003045_fibrosis1.79819807
24MP0001849_ear_inflammation1.79459653
25MP0004947_skin_inflammation1.77672501
26MP0009840_abnormal_foam_cell1.76484356
27MP0004858_abnormal_nervous_system1.72091692
28MP0003091_abnormal_cell_migration1.70791654
29MP0002877_abnormal_melanocyte_morpholog1.69514005
30MP0001873_stomach_inflammation1.68965222
31MP0004185_abnormal_adipocyte_glucose1.61323920
32MP0010368_abnormal_lymphatic_system1.61287354
33MP0008004_abnormal_stomach_pH1.60779444
34MP0000733_abnormal_muscle_development1.60620819
35MP0000685_abnormal_immune_system1.59192218
36MP0000467_abnormal_esophagus_morphology1.52387816
37MP0003453_abnormal_keratinocyte_physiol1.47330172
38MP0005023_abnormal_wound_healing1.45919073
39MP0005623_abnormal_meninges_morphology1.42533186
40MP0002098_abnormal_vibrissa_morphology1.41173413
41MP0002653_abnormal_ependyma_morphology1.40578758
42MP0005397_hematopoietic_system_phenotyp1.40509445
43MP0001545_abnormal_hematopoietic_system1.40509445
44MP0002909_abnormal_adrenal_gland1.36764078
45MP0000858_altered_metastatic_potential1.32747363
46MP0000751_myopathy1.32556113
47MP0004782_abnormal_surfactant_physiolog1.31659944
48MP0004381_abnormal_hair_follicle1.30223756
49MP0003075_altered_response_to1.27838641
50MP0008770_decreased_survivor_rate1.27755070
51* MP0005310_abnormal_salivary_gland1.27669179
52MP0003941_abnormal_skin_development1.26758656
53MP0000003_abnormal_adipose_tissue1.23305262
54MP0004233_abnormal_muscle_weight1.21806616
55MP0000569_abnormal_digit_pigmentation1.20477649
56MP0002796_impaired_skin_barrier1.19970572
57MP0002166_altered_tumor_susceptibility1.17911169
58MP0000465_gastrointestinal_hemorrhage1.16798622
59MP0005387_immune_system_phenotype1.15059818
60MP0001790_abnormal_immune_system1.15059818
61MP0000762_abnormal_tongue_morphology1.14876807
62MP0004808_abnormal_hematopoietic_stem1.12928082
63MP0003436_decreased_susceptibility_to1.12727874
64MP0003279_aneurysm1.12694030
65MP0003866_abnormal_defecation1.11866336
66MP0002060_abnormal_skin_morphology1.10885473
67MP0001958_emphysema1.10301118
68MP0009053_abnormal_anal_canal1.08749464
69MP0001851_eye_inflammation1.05925488
70MP0009780_abnormal_chondrocyte_physiolo1.05914170
71MP0010771_integument_phenotype1.04773249
72MP0003828_pulmonary_edema1.03193983
73MP0005375_adipose_tissue_phenotype1.01841639
74MP0001348_abnormal_lacrimal_gland1.00351152
75MP0010155_abnormal_intestine_physiology0.99571987
76MP0005464_abnormal_platelet_physiology0.99541625
77MP0000377_abnormal_hair_follicle0.97396835
78MP0000767_abnormal_smooth_muscle0.97117061
79MP0002234_abnormal_pharynx_morphology0.96303395
80MP0001915_intracranial_hemorrhage0.96113465
81MP0004087_abnormal_muscle_fiber0.96067403
82MP0006054_spinal_hemorrhage0.95374655
83MP0005423_abnormal_somatic_nervous0.94934098
84MP0005390_skeleton_phenotype0.94586221
85MP0004084_abnormal_cardiac_muscle0.91676458
86MP0002089_abnormal_postnatal_growth/wei0.91518797
87MP0003448_altered_tumor_morphology0.91395090
88MP0001533_abnormal_skeleton_physiology0.90691761
89MP0010307_abnormal_tumor_latency0.90141397
90MP0002925_abnormal_cardiovascular_devel0.89486185
91MP0010630_abnormal_cardiac_muscle0.89440187
92MP0009384_cardiac_valve_regurgitation0.89108892
93MP0003646_muscle_fatigue0.88046000
94MP0005058_abnormal_lysosome_morphology0.87637042
95MP0000537_abnormal_urethra_morphology0.87480112
96MP0000627_abnormal_mammary_gland0.86786737
97MP0002398_abnormal_bone_marrow0.84400273
98MP0004264_abnormal_extraembryonic_tissu0.84192941
99MP0001800_abnormal_humoral_immune0.84180132
100MP0006138_congestive_heart_failure0.83894569
101MP0005164_abnormal_response_to0.83768632
102MP0002998_abnormal_bone_remodeling0.83553136
103MP0005508_abnormal_skeleton_morphology0.83056946
104MP0005621_abnormal_cell_physiology0.82385646
105MP0005167_abnormal_blood-brain_barrier0.80688041
106MP0002006_tumorigenesis0.80418242
107MP0004272_abnormal_basement_membrane0.79689393
108MP0002452_abnormal_antigen_presenting0.79357598
109MP0003329_amyloid_beta_deposits0.78721106
110MP0006082_CNS_inflammation0.78554186
111MP0003283_abnormal_digestive_organ0.77418578
112MP0005000_abnormal_immune_tolerance0.76255664
113* MP0001216_abnormal_epidermal_layer0.75944686
114MP0002396_abnormal_hematopoietic_system0.75570353
115MP0010678_abnormal_skin_adnexa0.75345591
116MP0000534_abnormal_ureter_morphology0.75053571
117MP0001614_abnormal_blood_vessel0.74634812
118MP0005595_abnormal_vascular_smooth0.74618656
119MP0005501_abnormal_skin_physiology0.74259769
120MP0001243_abnormal_dermal_layer0.73788964
121MP0002419_abnormal_innate_immunity0.72440697
122* MP0008569_lethality_at_weaning0.72392310
123* MP0009931_abnormal_skin_appearance0.72213962
124MP0003724_increased_susceptibility_to0.71594404
125MP0000249_abnormal_blood_vessel0.71188175
126MP0002249_abnormal_larynx_morphology0.71145444
127MP0001819_abnormal_immune_cell0.71061842
128MP0002420_abnormal_adaptive_immunity0.70206773
129MP0000750_abnormal_muscle_regeneration0.69858853
130MP0005165_increased_susceptibility_to0.69639115
131MP0003183_abnormal_peptide_metabolism0.69482501
132MP0002295_abnormal_pulmonary_circulatio0.69416803
133MP0001542_abnormal_bone_strength0.68018676
134MP0002896_abnormal_bone_mineralization0.67822287
135MP0001784_abnormal_fluid_regulation0.67730112
136MP0002405_respiratory_system_inflammati0.67600945
137MP0005503_abnormal_tendon_morphology0.67459639
138MP0002722_abnormal_immune_system0.67224216
139MP0001879_abnormal_lymphatic_vessel0.67218115
140MP0002723_abnormal_immune_serum0.66706772
141MP0005410_abnormal_fertilization0.66537876
142MP0008874_decreased_physiological_sensi0.65161165
143MP0003795_abnormal_bone_structure0.65019099

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.59729906
2Protrusio acetabuli (HP:0003179)3.13355992
3Hyperacusis (HP:0010780)3.11877178
4Broad face (HP:0000283)3.11770605
5Milia (HP:0001056)3.02333668
6Shallow orbits (HP:0000586)3.00384780
7Distal upper limb amyotrophy (HP:0007149)3.00238800
8Upper limb amyotrophy (HP:0009129)3.00238800
9Obstructive sleep apnea (HP:0002870)2.85452528
10Vascular tortuosity (HP:0004948)2.74716294
11Hand muscle atrophy (HP:0009130)2.67495861
12Distal lower limb muscle weakness (HP:0009053)2.66330867
13Atrophic scars (HP:0001075)2.65816854
14Broad metatarsal (HP:0001783)2.64878440
15Abnormality of nail color (HP:0100643)2.54810020
16Right ventricular cardiomyopathy (HP:0011663)2.52597193
17Vertebral compression fractures (HP:0002953)2.47880190
18Fragile nails (HP:0001808)2.40979291
19Genu recurvatum (HP:0002816)2.37697898
20Mitral valve prolapse (HP:0001634)2.36329801
21Spinal rigidity (HP:0003306)2.36161792
22Blue sclerae (HP:0000592)2.34577690
23Ankle contracture (HP:0006466)2.34231448
24Polycythemia (HP:0001901)2.31681534
25Aortic aneurysm (HP:0004942)2.28656288
26Cervical subluxation (HP:0003308)2.28042797
27Fragile skin (HP:0001030)2.26163335
28Wormian bones (HP:0002645)2.25249263
29Abnormality of the fingertips (HP:0001211)2.24665271
30Premature rupture of membranes (HP:0001788)2.23147109
31Increased connective tissue (HP:0009025)2.23037494
32Insomnia (HP:0100785)2.21044363
33Enlarged penis (HP:0000040)2.17465808
34Dysmetric saccades (HP:0000641)2.17360457
35Macroorchidism (HP:0000053)2.17262775
36Distal lower limb amyotrophy (HP:0008944)2.15157171
37Alopecia of scalp (HP:0002293)2.14896805
38Increased IgE level (HP:0003212)2.13032135
39Onycholysis (HP:0001806)2.12385388
40Aneurysm (HP:0002617)2.12199750
41Hypercortisolism (HP:0001578)2.11401040
42Dilatation of the ascending aorta (HP:0005111)2.08764531
43Increased density of long bones (HP:0006392)2.08038061
44Natal tooth (HP:0000695)2.08011651
45Advanced eruption of teeth (HP:0006288)2.07656310
46Plantar hyperkeratosis (HP:0007556)2.06781998
47Lower limb amyotrophy (HP:0007210)2.06773218
48Nail dystrophy (HP:0008404)2.06772827
49Elfin facies (HP:0004428)2.05987802
50Neoplasm of the heart (HP:0100544)2.02943741
51Long palpebral fissure (HP:0000637)2.02329460
52Bladder diverticulum (HP:0000015)2.01407563
53Disproportionate tall stature (HP:0001519)2.01247208
54Follicular hyperkeratosis (HP:0007502)1.97692990
55Abnormality of the nasal mucosa (HP:0000433)1.97372908
56Osteolytic defects of the hand bones (HP:0009699)1.97100862
57Osteolytic defects of the phalanges of the hand (HP:0009771)1.97100862
58Nasal polyposis (HP:0100582)1.95917825
59Cerebral inclusion bodies (HP:0100314)1.95349327
60Hyperparathyroidism (HP:0000843)1.95247998
61Flat acetabular roof (HP:0003180)1.95198289
62Short nail (HP:0001799)1.95176298
63Abnormality of the distal phalanx of the thumb (HP:0009617)1.94577902
64Joint laxity (HP:0001388)1.90773174
65Neurofibrillary tangles (HP:0002185)1.89925120
66Increased variability in muscle fiber diameter (HP:0003557)1.88410285
67Hemiplegia (HP:0002301)1.87925606
68Axonal loss (HP:0003447)1.87667031
69Pustule (HP:0200039)1.87450410
70Urethral obstruction (HP:0000796)1.87355370
71Mildly elevated creatine phosphokinase (HP:0008180)1.85822670
72Malnutrition (HP:0004395)1.85809741
73Hyporeflexia of lower limbs (HP:0002600)1.85344345
74Aortic dissection (HP:0002647)1.85043946
75Segmental peripheral demyelination/remyelination (HP:0003481)1.84657366
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84534872
77Short 4th metacarpal (HP:0010044)1.84534872
78Abnormality of the gastric mucosa (HP:0004295)1.84467965
79Tetraparesis (HP:0002273)1.84038778
80Hematochezia (HP:0002573)1.83027795
81Spondylolisthesis (HP:0003302)1.82856138
82Lip pit (HP:0100267)1.82378535
83Ulnar bowing (HP:0003031)1.81118435
84Dysostosis multiplex (HP:0000943)1.80672084
85Abnormality of the distal phalanges of the toes (HP:0010182)1.79973636
86Ventricular fibrillation (HP:0001663)1.79802185
87Neonatal short-limb short stature (HP:0008921)1.79750361
88Fatigue (HP:0012378)1.79073324
89Broad palm (HP:0001169)1.78846882
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78496916
91Increased cerebral lipofuscin (HP:0011813)1.78482114
92Abnormal blistering of the skin (HP:0008066)1.78081186
93Slender build (HP:0001533)1.78054970
94Mitral regurgitation (HP:0001653)1.76632098
95Striae distensae (HP:0001065)1.76403990
96Supranuclear gaze palsy (HP:0000605)1.75969768
97Hemorrhage of the eye (HP:0011885)1.75850812
98Peritonitis (HP:0002586)1.74132208
99Abnormal ossification of hand bones (HP:0005921)1.74017098
100Abnormality of macrophages (HP:0004311)1.72805741
101Achilles tendon contracture (HP:0001771)1.71866473
102Reticulocytosis (HP:0001923)1.71352481
103Spinal cord compression (HP:0002176)1.69427985
104Autoimmune thrombocytopenia (HP:0001973)1.69129099
105Sparse lateral eyebrow (HP:0005338)1.69103209
106Eczematoid dermatitis (HP:0000976)1.69047953
107Long toe (HP:0010511)1.68849005
108Radial bowing (HP:0002986)1.68246262
109J-shaped sella turcica (HP:0002680)1.68015322
110Difficulty running (HP:0009046)1.67979067
111Abnormality of the Achilles tendon (HP:0005109)1.66506922
112Ankyloglossia (HP:0010296)1.65744611
113Pointed chin (HP:0000307)1.65492019
114Rapidly progressive (HP:0003678)1.65263566
115Urinary glycosaminoglycan excretion (HP:0003541)1.65253220
116Mucopolysacchariduria (HP:0008155)1.65253220
117Heterotopia (HP:0002282)1.65131505
118Interstitial pulmonary disease (HP:0006530)1.64750193
119Elbow flexion contracture (HP:0002987)1.64127116
120Hyperextensible skin (HP:0000974)1.63872434
121Hypoplasia of dental enamel (HP:0006297)1.63761219
122Abnormality of skeletal muscle fiber size (HP:0012084)1.63039851
123Loss of speech (HP:0002371)1.62998367
124Abnormality of polysaccharide metabolism (HP:0011012)1.62669561
125Abnormality of glycosaminoglycan metabolism (HP:0004371)1.62669561
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.62669561
127Ridged nail (HP:0001807)1.62590801
128Trigonocephaly (HP:0000243)1.62464406
129Abnormality of carpal bone ossification (HP:0006257)1.61923097
130Asymmetric septal hypertrophy (HP:0001670)1.61902827
131Abnormality of oral frenula (HP:0000190)1.61696929
132Flat cornea (HP:0007720)1.61444780
133Deviation of the hallux (HP:0010051)1.61385161
134Polygenic inheritance (HP:0010982)1.61143270
135Coxa vara (HP:0002812)1.60437518
136Bowel diverticulosis (HP:0005222)1.59930573
137Periodontitis (HP:0000704)1.59466530
138Hallux valgus (HP:0001822)1.59228010
139Arterial tortuosity (HP:0005116)1.58370512
140Persistence of primary teeth (HP:0006335)1.57962089
141Petechiae (HP:0000967)1.57902476
142Difficulty climbing stairs (HP:0003551)1.57728542
143Frequent falls (HP:0002359)1.57482924
144Cellulitis (HP:0100658)1.56843069
145Type 1 muscle fiber predominance (HP:0003803)1.56735164
146Genetic anticipation (HP:0003743)1.55903666
147Thick nail (HP:0001805)1.55612337
148Narrow palate (HP:0000189)1.55477756
149Thin bony cortex (HP:0002753)1.54922324
150Bowed forearm bones (HP:0003956)1.54829825
151Bowing of the arm (HP:0006488)1.54829825
152Ventricular tachycardia (HP:0004756)1.52346453
153Emphysema (HP:0002097)1.51044642
154Pili torti (HP:0003777)1.50142993
155Abnormality of the lower motor neuron (HP:0002366)1.49507748
156Renovascular hypertension (HP:0100817)1.49386035
157Sudden death (HP:0001699)1.49077859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.01865086
2CDK123.43249139
3EPHA23.19457341
4ERN13.09509727
5PKN22.65295406
6SMG12.64613593
7EEF2K2.63369652
8RIPK12.44044154
9EPHA32.25595878
10TESK12.25232476
11PRPF4B2.22038061
12TAOK12.02808446
13MAP3K101.93652887
14PRKD31.86302668
15MST1R1.80692423
16TTN1.79705740
17PTK61.72977968
18BMX1.71401192
19SIK21.70388954
20KSR21.68457973
21CAMKK11.65629221
22MAP3K31.65247731
23MAP3K91.63531513
24IRAK31.63292884
25ICK1.61754891
26EPHB11.60538805
27CAMK1G1.59072416
28SIK11.51784737
29CAMK1D1.41614741
30ARAF1.41486187
31DMPK1.38653898
32BRD41.34751440
33MAP4K11.34013826
34PDGFRA1.33976012
35ALK1.27550812
36MAP3K71.26083804
37MAP3K131.25868794
38MAP2K31.21741892
39MET1.21707674
40TESK21.18002855
41RIPK41.17721703
42PAK61.15320071
43LRRK21.15245481
44JAK11.15177697
45TYK21.14075682
46PTK21.10756508
47STK101.03990275
48PRKCH1.03930531
49TBK11.03150924
50MAP3K21.02738064
51TAOK21.02495236
52MYLK1.01779933
53RET1.00432098
54MTOR0.99352858
55TYRO30.96304592
56PRKD20.95443886
57PAK40.95292049
58LATS10.94027640
59MAP3K110.91998076
60GRK60.87172663
61MARK20.86994842
62LATS20.86557244
63STK380.86036322
64DDR20.85412279
65HCK0.84928045
66TAOK30.84922485
67FGFR30.83309074
68JAK30.80487595
69JAK20.80050303
70PDGFRB0.79533080
71TGFBR20.78627568
72* RPS6KA20.76291593
73STK110.75312541
74PAK20.73881407
75MAPKAPK30.70012194
76NTRK10.69841843
77FGFR40.69375081
78ERBB20.69307419
79IKBKE0.65793913
80SGK30.64113499
81LMTK20.60942255
82PRKG20.60802462
83CDK60.60515567
84PIM20.60070701
85ZAP700.59996061
86IRAK40.59352212
87PTK2B0.59173225
88CHUK0.58735259
89MAP3K10.58142468
90PRKD10.58071389
91MAP3K80.57302819
92MAP2K20.56420306
93FES0.55964869
94TNK20.55796236
95CSK0.54643210
96HIPK20.53641952
97AKT30.52862369
98FER0.51739851
99CDK70.51413190
100CDC42BPA0.50496744
101RPS6KA40.49274640
102KIT0.48128650
103CDK90.47398549
104BRAF0.47211292
105MOS0.47205128
106MAP2K10.46851385
107CAMK40.45789517
108MAPKAPK20.45302786
109EPHB20.44773492
110PDPK10.44629938
111DYRK1B0.44594963
112PDK10.43440727
113MATK0.43416379
114KSR10.42803206
115SIK30.41298296
116BTK0.40475115
117PRKAA20.40380548
118MAPK70.39971759
119STK30.39709325
120DAPK20.39646382
121MAP3K140.39018345
122SRC0.38396244
123MAPK120.38381455
124MAP3K60.37897856
125NTRK20.37718812
126FYN0.36411830
127WNK10.35439946
128RAF10.35114747
129BLK0.34955081
130TRPM70.34259085
131* RPS6KL10.33401000
132* RPS6KC10.33401000
133MAPK110.30668696

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20361514
2Other glycan degradation_Homo sapiens_hsa005111.83323177
3Chronic myeloid leukemia_Homo sapiens_hsa052201.56134516
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45733745
5Osteoclast differentiation_Homo sapiens_hsa043801.40587061
6VEGF signaling pathway_Homo sapiens_hsa043701.34977262
7Dorso-ventral axis formation_Homo sapiens_hsa043201.33469620
8B cell receptor signaling pathway_Homo sapiens_hsa046621.33249159
9Thyroid cancer_Homo sapiens_hsa052161.32702422
10Neurotrophin signaling pathway_Homo sapiens_hsa047221.32655678
11Leishmaniasis_Homo sapiens_hsa051401.31580773
12Toxoplasmosis_Homo sapiens_hsa051451.29941794
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29548918
14mTOR signaling pathway_Homo sapiens_hsa041501.26106842
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25839452
16Glioma_Homo sapiens_hsa052141.25398728
17Acute myeloid leukemia_Homo sapiens_hsa052211.24350271
18Focal adhesion_Homo sapiens_hsa045101.23327059
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22687592
20* Gastric acid secretion_Homo sapiens_hsa049711.21534438
21Dilated cardiomyopathy_Homo sapiens_hsa054141.20945746
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20453724
23Pancreatic cancer_Homo sapiens_hsa052121.18353106
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17408337
25* Proteoglycans in cancer_Homo sapiens_hsa052051.15119664
26ECM-receptor interaction_Homo sapiens_hsa045121.14680736
27Small cell lung cancer_Homo sapiens_hsa052221.14467780
28Amoebiasis_Homo sapiens_hsa051461.13915750
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13812663
30* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12930600
31Non-small cell lung cancer_Homo sapiens_hsa052231.12464932
32Type II diabetes mellitus_Homo sapiens_hsa049301.11329149
33GnRH signaling pathway_Homo sapiens_hsa049121.11253003
34Prion diseases_Homo sapiens_hsa050201.10531156
35Lysosome_Homo sapiens_hsa041421.09359034
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09231984
37Estrogen signaling pathway_Homo sapiens_hsa049151.08771753
38Notch signaling pathway_Homo sapiens_hsa043301.08152080
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06485547
40Endometrial cancer_Homo sapiens_hsa052131.05486553
41Platelet activation_Homo sapiens_hsa046111.05453967
42Hepatitis C_Homo sapiens_hsa051601.05232326
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04051494
44Renal cell carcinoma_Homo sapiens_hsa052111.03895101
45Olfactory transduction_Homo sapiens_hsa047401.03148365
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02948726
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02892466
48* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01538382
49Prostate cancer_Homo sapiens_hsa052150.99200342
50Insulin resistance_Homo sapiens_hsa049310.97701539
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97091180
52Oxytocin signaling pathway_Homo sapiens_hsa049210.96781696
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96595777
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95453868
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.95240872
56MicroRNAs in cancer_Homo sapiens_hsa052060.94390373
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.94140426
58Chemokine signaling pathway_Homo sapiens_hsa040620.93100514
59Prolactin signaling pathway_Homo sapiens_hsa049170.92812128
60Adherens junction_Homo sapiens_hsa045200.92274625
61Long-term potentiation_Homo sapiens_hsa047200.91544079
62Endocytosis_Homo sapiens_hsa041440.91381292
63T cell receptor signaling pathway_Homo sapiens_hsa046600.90281920
64* Salivary secretion_Homo sapiens_hsa049700.90042818
65Malaria_Homo sapiens_hsa051440.89823099
66Apoptosis_Homo sapiens_hsa042100.89762393
67Vibrio cholerae infection_Homo sapiens_hsa051100.89167810
68Bladder cancer_Homo sapiens_hsa052190.89056943
69Tuberculosis_Homo sapiens_hsa051520.88870074
70* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88458283
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.88399266
72TNF signaling pathway_Homo sapiens_hsa046680.88336163
73Protein digestion and absorption_Homo sapiens_hsa049740.87368406
74ErbB signaling pathway_Homo sapiens_hsa040120.87110322
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86724053
76Galactose metabolism_Homo sapiens_hsa000520.86067094
77Hepatitis B_Homo sapiens_hsa051610.86032994
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84749267
79Influenza A_Homo sapiens_hsa051640.83654167
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83522012
81Rap1 signaling pathway_Homo sapiens_hsa040150.83090406
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83071063
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82656320
84MAPK signaling pathway_Homo sapiens_hsa040100.81606888
85Colorectal cancer_Homo sapiens_hsa052100.81466099
86Gap junction_Homo sapiens_hsa045400.80531415
87Fructose and mannose metabolism_Homo sapiens_hsa000510.80173713
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79582992
89Shigellosis_Homo sapiens_hsa051310.79303093
90Renin secretion_Homo sapiens_hsa049240.79137385
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.78758457
92HIF-1 signaling pathway_Homo sapiens_hsa040660.78351042
93Viral myocarditis_Homo sapiens_hsa054160.78111239
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77025633
95Circadian entrainment_Homo sapiens_hsa047130.75249761
96Choline metabolism in cancer_Homo sapiens_hsa052310.75038926
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74844095
98Axon guidance_Homo sapiens_hsa043600.74195063
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.73729015
100Salmonella infection_Homo sapiens_hsa051320.73571739
101Cholinergic synapse_Homo sapiens_hsa047250.73541893
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73134404
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.72966302
104Tight junction_Homo sapiens_hsa045300.70943729
105* cAMP signaling pathway_Homo sapiens_hsa040240.69650084
106Inositol phosphate metabolism_Homo sapiens_hsa005620.69352617
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.69217410
108Lysine degradation_Homo sapiens_hsa003100.67921658
109Insulin signaling pathway_Homo sapiens_hsa049100.67417715
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65250126
111AMPK signaling pathway_Homo sapiens_hsa041520.65060960
112Melanogenesis_Homo sapiens_hsa049160.64963903
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64660659
114HTLV-I infection_Homo sapiens_hsa051660.63803837
115Cocaine addiction_Homo sapiens_hsa050300.62697055
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.62480197
117FoxO signaling pathway_Homo sapiens_hsa040680.62386885
118Pathways in cancer_Homo sapiens_hsa052000.61803401
119Sphingolipid metabolism_Homo sapiens_hsa006000.60871609
120Pentose phosphate pathway_Homo sapiens_hsa000300.60156261
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57189434
122Phagosome_Homo sapiens_hsa041450.55607707
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52762013

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