SLC8A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.65109704
2synaptic vesicle maturation (GO:0016188)6.63704502
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.54919318
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.37667788
5vocalization behavior (GO:0071625)5.85517658
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.82369878
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.75337588
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.48773224
9regulation of glutamate receptor signaling pathway (GO:1900449)5.44161113
10synaptic vesicle exocytosis (GO:0016079)5.41725848
11glutamate secretion (GO:0014047)5.37924005
12regulation of neuronal synaptic plasticity (GO:0048168)5.08703893
13regulation of synaptic vesicle exocytosis (GO:2000300)5.06586217
14regulation of long-term neuronal synaptic plasticity (GO:0048169)5.03952812
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.99746692
16exploration behavior (GO:0035640)4.99673774
17cerebellar granule cell differentiation (GO:0021707)4.96430933
18protein localization to synapse (GO:0035418)4.91504358
19regulation of synapse structural plasticity (GO:0051823)4.90964159
20dendritic spine morphogenesis (GO:0060997)4.68994710
21layer formation in cerebral cortex (GO:0021819)4.54953137
22regulation of synaptic vesicle transport (GO:1902803)4.53415312
23neuronal action potential propagation (GO:0019227)4.52800643
24synaptic transmission, glutamatergic (GO:0035249)4.50025808
25neurotransmitter secretion (GO:0007269)4.48956400
26neurotransmitter-gated ion channel clustering (GO:0072578)4.45207716
27glutamate receptor signaling pathway (GO:0007215)4.33008620
28long-term memory (GO:0007616)4.31067817
29positive regulation of membrane potential (GO:0045838)4.22497163
30regulation of dendritic spine morphogenesis (GO:0061001)4.20465057
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.16777838
32neuron cell-cell adhesion (GO:0007158)4.15252200
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15023026
34potassium ion homeostasis (GO:0055075)4.12603430
35regulation of synapse maturation (GO:0090128)4.09249564
36neuron-neuron synaptic transmission (GO:0007270)4.07498135
37amino acid import (GO:0043090)4.00958305
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.99875501
39regulation of synaptic plasticity (GO:0048167)3.97324031
40positive regulation of synapse maturation (GO:0090129)3.93926355
41neuromuscular process controlling balance (GO:0050885)3.93014615
42cellular potassium ion homeostasis (GO:0030007)3.92779047
43gamma-aminobutyric acid transport (GO:0015812)3.89868840
44regulation of postsynaptic membrane potential (GO:0060078)3.89383660
45potassium ion import (GO:0010107)3.88859913
46proline transport (GO:0015824)3.87395480
47sodium ion export (GO:0071436)3.82148977
48axon ensheathment in central nervous system (GO:0032291)3.80660999
49central nervous system myelination (GO:0022010)3.80660999
50regulation of voltage-gated calcium channel activity (GO:1901385)3.80205440
51auditory behavior (GO:0031223)3.70778366
52G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.70654326
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.69298221
54activation of protein kinase A activity (GO:0034199)3.65610472
55negative regulation of dendrite morphogenesis (GO:0050774)3.65474538
56dendritic spine organization (GO:0097061)3.58943922
57cellular sodium ion homeostasis (GO:0006883)3.56869087
58positive regulation of neurotransmitter secretion (GO:0001956)3.54454502
59transmission of nerve impulse (GO:0019226)3.51422170
60long-term synaptic potentiation (GO:0060291)3.51200386
61neurotransmitter transport (GO:0006836)3.50689331
62regulation of neurotransmitter secretion (GO:0046928)3.50331134
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46989064
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.46709619
65positive regulation of dendritic spine development (GO:0060999)3.46623324
66regulation of dendritic spine development (GO:0060998)3.46520921
67prepulse inhibition (GO:0060134)3.46067565
68positive regulation of neurotransmitter transport (GO:0051590)3.42015266
69synaptic vesicle endocytosis (GO:0048488)3.41148187
70positive regulation of dendritic spine morphogenesis (GO:0061003)3.40991205
71neuron recognition (GO:0008038)3.38811793
72neuromuscular synaptic transmission (GO:0007274)3.38032790
73response to auditory stimulus (GO:0010996)3.37847244
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37281301
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33207701
76regulation of neurotransmitter levels (GO:0001505)3.31659144
77neuronal ion channel clustering (GO:0045161)3.30391434
78regulation of vesicle fusion (GO:0031338)3.29978338
79cell differentiation in hindbrain (GO:0021533)3.28757826
80cell communication by electrical coupling (GO:0010644)3.27762616
81regulation of ARF protein signal transduction (GO:0032012)3.27598453
82membrane depolarization (GO:0051899)3.26932384
83dendrite morphogenesis (GO:0048813)3.25136024
84regulation of neurotransmitter transport (GO:0051588)3.24947587
85L-amino acid import (GO:0043092)3.24384204
86postsynaptic membrane organization (GO:0001941)3.23851593
87axonal fasciculation (GO:0007413)3.20754764
88chemosensory behavior (GO:0007635)3.20474008
89synaptic transmission (GO:0007268)3.19818712
90cytoskeletal anchoring at plasma membrane (GO:0007016)3.19724890
91learning (GO:0007612)3.19583634
92presynaptic membrane organization (GO:0097090)3.18965667
93behavioral defense response (GO:0002209)3.17257557
94behavioral fear response (GO:0001662)3.17257557
95glycine transport (GO:0015816)3.16823119
96cerebellar Purkinje cell differentiation (GO:0021702)3.16001942
97cell migration in hindbrain (GO:0021535)3.14694191
98neuromuscular process controlling posture (GO:0050884)3.13566567
99acidic amino acid transport (GO:0015800)3.12537724
100regulation of synaptic transmission (GO:0050804)3.11960531
101gamma-aminobutyric acid signaling pathway (GO:0007214)3.11637050
102innervation (GO:0060384)3.11353523
103synaptic vesicle transport (GO:0048489)3.11159901
104establishment of synaptic vesicle localization (GO:0097480)3.11159901
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10392723
106membrane depolarization during action potential (GO:0086010)3.09945873
107neuromuscular process (GO:0050905)3.09923433
108positive regulation of synaptic transmission (GO:0050806)3.09666000
109vesicle docking involved in exocytosis (GO:0006904)3.09643588
110G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09429033
111regulation of exocytosis (GO:0017157)3.09411928
112membrane hyperpolarization (GO:0060081)3.08279828
113negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05828800
114regulation of calcium ion-dependent exocytosis (GO:0017158)3.05207910
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04476541
116regulation of female receptivity (GO:0045924)3.04265855
117intraspecies interaction between organisms (GO:0051703)3.03338586
118social behavior (GO:0035176)3.03338586
119positive regulation of dendrite development (GO:1900006)3.01839423
120vesicle transport along microtubule (GO:0047496)3.00454248
121cerebellar Purkinje cell layer development (GO:0021680)3.00229558
122signal release (GO:0023061)3.00062521
123long term synaptic depression (GO:0060292)2.96660326
124fear response (GO:0042596)2.94613443
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94534524

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22817232
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16197042
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14988330
4RARB_27405468_Chip-Seq_BRAIN_Mouse3.09557862
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07950956
6GBX2_23144817_ChIP-Seq_PC3_Human2.96881473
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85168677
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85168677
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.84393878
10DROSHA_22980978_ChIP-Seq_HELA_Human2.81540037
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75228932
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63346678
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62670216
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61080659
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51448601
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.50241825
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.50125787
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46944986
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39080771
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.37244045
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35128062
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.33026996
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.32775902
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.32093812
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.19160213
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02522738
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98591463
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86644482
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.81311426
30AR_21572438_ChIP-Seq_LNCaP_Human1.80699266
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56641049
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52477387
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46709317
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45824517
35* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43348271
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.43000592
37SMAD4_21799915_ChIP-Seq_A2780_Human1.41590319
38* KDM2B_26808549_Chip-Seq_K562_Human1.35084678
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33712866
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33650484
41* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28306780
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28144579
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27387087
44ZNF274_21170338_ChIP-Seq_K562_Hela1.25076452
45OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23960522
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.22714014
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22093774
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21932856
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21902226
50AR_19668381_ChIP-Seq_PC3_Human1.21698160
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.20353405
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.18848742
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16939181
54* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16138547
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13255327
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13204094
57* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12127928
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.11603471
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09426090
60AR_25329375_ChIP-Seq_VCAP_Human1.08115925
61P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07592614
62TAF15_26573619_Chip-Seq_HEK293_Human1.07029538
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06783225
64RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06570330
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06413677
66STAT3_23295773_ChIP-Seq_U87_Human1.06369651
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06223489
68LXR_22292898_ChIP-Seq_THP-1_Human1.04963393
69OCT4_19829295_ChIP-Seq_ESCs_Human1.02398475
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02155343
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.01641499
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00984643
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00761997
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00222408
75P300_19829295_ChIP-Seq_ESCs_Human0.99135860
76YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97558298
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97308033
78SMAD3_21741376_ChIP-Seq_HESCs_Human0.97169130
79CTCF_27219007_Chip-Seq_Bcells_Human0.96309100
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96217011
81* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95462561
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.93872289
83CBX2_27304074_Chip-Seq_ESCs_Mouse0.93751255
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93652770
85ARNT_22903824_ChIP-Seq_MCF-7_Human0.93158791
86* TET1_21490601_ChIP-Seq_MESCs_Mouse0.93041844
87* TCF4_23295773_ChIP-Seq_U87_Human0.92907800
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.92226804
89TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91869127
90BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91526713
91DPY_21335234_ChIP-Seq_ESCs_Mouse0.91475025
92KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91373378
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91160211
94RXR_22108803_ChIP-Seq_LS180_Human0.91002418
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90477381
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.90466021
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90180460
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90110753
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90069446
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89610769
101SMC4_20622854_ChIP-Seq_HELA_Human0.88786127
102TP53_16413492_ChIP-PET_HCT116_Human0.88550154
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88114585
104AHR_22903824_ChIP-Seq_MCF-7_Human0.87845093
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.86597991
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85542407
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84980754
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84835272
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84702501
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84445650
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84280638
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.83682657
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82676223
114KLF4_19829295_ChIP-Seq_ESCs_Human0.82410226
115* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82133111
116RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81190175
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.81104257
118SMAD4_21741376_ChIP-Seq_ESCs_Human0.80052791
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79724384
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79724384
121RNF2_27304074_Chip-Seq_NSC_Mouse0.79435099
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79365608
123RUNX2_22187159_ChIP-Seq_PCA_Human0.79178404
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77882323
125CREB1_26743006_Chip-Seq_LNCaP_Human0.77620371
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73873737
127NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.70124787
128P68_20966046_ChIP-Seq_HELA_Human0.69549558
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68769890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.88063738
2MP0003880_abnormal_central_pattern4.66930494
3* MP0003635_abnormal_synaptic_transmissio4.47299937
4MP0004270_analgesia3.91729454
5MP0002822_catalepsy3.64360698
6MP0009745_abnormal_behavioral_response3.62877638
7* MP0002063_abnormal_learning/memory/cond3.58948195
8MP0002064_seizures3.26407075
9MP0009046_muscle_twitch2.99791512
10MP0005423_abnormal_somatic_nervous2.88190871
11MP0002572_abnormal_emotion/affect_behav2.87662366
12MP0001968_abnormal_touch/_nociception2.85114599
13MP0001486_abnormal_startle_reflex2.67460172
14MP0002272_abnormal_nervous_system2.58628858
15MP0002734_abnormal_mechanical_nocicepti2.55950721
16MP0001501_abnormal_sleep_pattern2.25427157
17MP0009780_abnormal_chondrocyte_physiolo2.17445496
18MP0008569_lethality_at_weaning2.06466632
19MP0001440_abnormal_grooming_behavior2.05802478
20MP0002736_abnormal_nociception_after2.04845398
21MP0002735_abnormal_chemical_nociception1.98555352
22MP0004858_abnormal_nervous_system1.94068047
23MP0003329_amyloid_beta_deposits1.90307348
24MP0002733_abnormal_thermal_nociception1.90094452
25MP0003123_paternal_imprinting1.88499481
26MP0001970_abnormal_pain_threshold1.87457422
27* MP0004811_abnormal_neuron_physiology1.84287062
28MP0002909_abnormal_adrenal_gland1.81300570
29MP0003879_abnormal_hair_cell1.79295114
30MP0002067_abnormal_sensory_capabilities1.77448132
31MP0002557_abnormal_social/conspecific_i1.73330927
32MP0000778_abnormal_nervous_system1.69412634
33MP0002184_abnormal_innervation1.67402700
34MP0004924_abnormal_behavior1.65662164
35MP0005386_behavior/neurological_phenoty1.65662164
36MP0004885_abnormal_endolymph1.58044303
37MP0000955_abnormal_spinal_cord1.54619387
38MP0005646_abnormal_pituitary_gland1.51711836
39MP0003633_abnormal_nervous_system1.45737639
40MP0002066_abnormal_motor_capabilities/c1.42983002
41MP0002882_abnormal_neuron_morphology1.38909127
42MP0003075_altered_response_to1.34495861
43MP0001984_abnormal_olfaction1.28466827
44MP0003787_abnormal_imprinting1.25901109
45MP0003631_nervous_system_phenotype1.20829737
46MP0001502_abnormal_circadian_rhythm1.12440447
47MP0002152_abnormal_brain_morphology1.12054505
48MP0001905_abnormal_dopamine_level1.09215672
49MP0005645_abnormal_hypothalamus_physiol1.08922631
50MP0001529_abnormal_vocalization1.08414542
51MP0008872_abnormal_physiological_respon1.07955566
52MP0008877_abnormal_DNA_methylation1.04613850
53MP0001177_atelectasis1.03728832
54MP0008874_decreased_physiological_sensi1.03486988
55MP0000569_abnormal_digit_pigmentation1.02153698
56MP0008961_abnormal_basal_metabolism1.01987743
57MP0004142_abnormal_muscle_tone1.01625587
58MP0003283_abnormal_digestive_organ1.01121387
59MP0002638_abnormal_pupillary_reflex0.97590515
60MP0002069_abnormal_eating/drinking_beha0.96930118
61MP0001348_abnormal_lacrimal_gland0.94459049
62MP0003690_abnormal_glial_cell0.93812740
63MP0006276_abnormal_autonomic_nervous0.93367553
64MP0005167_abnormal_blood-brain_barrier0.93178992
65MP0000751_myopathy0.92048269
66MP0003121_genomic_imprinting0.90398052
67MP0004145_abnormal_muscle_electrophysio0.87099142
68MP0010234_abnormal_vibrissa_follicle0.86860616
69MP0000604_amyloidosis0.86828267
70MP0004510_myositis0.86797502
71MP0000920_abnormal_myelination0.85802367
72MP0002229_neurodegeneration0.84368735
73MP0003632_abnormal_nervous_system0.83503542
74MP0005535_abnormal_body_temperature0.83113099
75MP0004085_abnormal_heartbeat0.81449197
76MP0001986_abnormal_taste_sensitivity0.79216582
77MP0003634_abnormal_glial_cell0.78746184
78MP0004147_increased_porphyrin_level0.75432983
79MP0002090_abnormal_vision0.74857667
80MP0000013_abnormal_adipose_tissue0.73862335
81MP0001346_abnormal_lacrimal_gland0.73604090
82MP0004742_abnormal_vestibular_system0.72404606
83MP0001188_hyperpigmentation0.72175229
84MP0001963_abnormal_hearing_physiology0.72131576
85MP0003122_maternal_imprinting0.71967672
86MP0005394_taste/olfaction_phenotype0.70274891
87MP0005499_abnormal_olfactory_system0.70274891
88MP0005409_darkened_coat_color0.67335969
89MP0003172_abnormal_lysosome_physiology0.64717805
90MP0005623_abnormal_meninges_morphology0.64383521
91MP0005551_abnormal_eye_electrophysiolog0.64304036
92MP0004484_altered_response_of0.63272178
93MP0003137_abnormal_impulse_conducting0.63211287
94MP0000631_abnormal_neuroendocrine_gland0.63043319
95MP0010386_abnormal_urinary_bladder0.62419744
96MP0001485_abnormal_pinna_reflex0.61226210
97MP0002752_abnormal_somatic_nervous0.59675691
98MP0004233_abnormal_muscle_weight0.59590307
99MP0001664_abnormal_digestion0.58090493
100MP0004215_abnormal_myocardial_fiber0.57091003
101MP0003861_abnormal_nervous_system0.54994173
102MP0005166_decreased_susceptibility_to0.54745655
103MP0010768_mortality/aging0.54071634
104MP0010770_preweaning_lethality0.53677456
105MP0002082_postnatal_lethality0.53677456
106MP0002653_abnormal_ependyma_morphology0.52970804
107MP0010769_abnormal_survival0.52062925
108MP0004043_abnormal_pH_regulation0.51523449
109MP0000579_abnormal_nail_morphology0.50489178
110MP0005187_abnormal_penis_morphology0.50278555
111MP0001943_abnormal_respiration0.50254912
112MP0000026_abnormal_inner_ear0.50190679
113MP0004130_abnormal_muscle_cell0.50019728
114MP0003956_abnormal_body_size0.49444451
115MP0003938_abnormal_ear_development0.44847893

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.22065885
2Focal motor seizures (HP:0011153)7.69818013
3Focal seizures (HP:0007359)5.92317818
4Visual hallucinations (HP:0002367)5.58743347
5Epileptic encephalopathy (HP:0200134)4.67293171
6Action tremor (HP:0002345)4.41502156
7Progressive cerebellar ataxia (HP:0002073)4.39557305
8Atonic seizures (HP:0010819)4.10123417
9Febrile seizures (HP:0002373)4.04633270
10Absence seizures (HP:0002121)3.88415070
11Generalized tonic-clonic seizures (HP:0002069)3.80755289
12Poor eye contact (HP:0000817)3.77919044
13Impaired vibration sensation in the lower limbs (HP:0002166)3.76975027
14Ankle clonus (HP:0011448)3.64494832
15Broad-based gait (HP:0002136)3.63467242
16Gaze-evoked nystagmus (HP:0000640)3.58326318
17Dialeptic seizures (HP:0011146)3.58071789
18Cerebral hypomyelination (HP:0006808)3.57298378
19Supranuclear gaze palsy (HP:0000605)3.53208198
20Depression (HP:0000716)3.51816270
21Abnormality of the lower motor neuron (HP:0002366)3.44850414
22Dysdiadochokinesis (HP:0002075)3.40975080
23Abnormal social behavior (HP:0012433)3.36079040
24Impaired social interactions (HP:0000735)3.36079040
25Papilledema (HP:0001085)3.35491244
26Dysmetria (HP:0001310)3.34595268
27Urinary bladder sphincter dysfunction (HP:0002839)3.27475216
28Postural instability (HP:0002172)3.24477646
29Anxiety (HP:0000739)3.18872606
30Mutism (HP:0002300)3.18226191
31Annular pancreas (HP:0001734)3.10125892
32Torticollis (HP:0000473)3.06762974
33Akinesia (HP:0002304)3.03761899
34Impaired smooth pursuit (HP:0007772)3.00336232
35Abnormal eating behavior (HP:0100738)2.94822180
36Amblyopia (HP:0000646)2.94751156
37Genetic anticipation (HP:0003743)2.93380381
38Focal dystonia (HP:0004373)2.90845708
39Intention tremor (HP:0002080)2.90349857
40Truncal ataxia (HP:0002078)2.89190267
41Urinary urgency (HP:0000012)2.84655271
42Sleep apnea (HP:0010535)2.80598764
43Stereotypic behavior (HP:0000733)2.78688160
44Hemiplegia (HP:0002301)2.74847154
45Hyperventilation (HP:0002883)2.68312893
46Megalencephaly (HP:0001355)2.68185336
47Ventricular fibrillation (HP:0001663)2.67577903
48Spastic gait (HP:0002064)2.66406514
49Hemiparesis (HP:0001269)2.65490719
50Scanning speech (HP:0002168)2.63506296
51Abnormality of ocular smooth pursuit (HP:0000617)2.63461369
52Dysmetric saccades (HP:0000641)2.58474976
53Impaired vibratory sensation (HP:0002495)2.57846666
54Bradykinesia (HP:0002067)2.57771768
55Cerebral inclusion bodies (HP:0100314)2.57727061
56Polyphagia (HP:0002591)2.57382522
57Pointed chin (HP:0000307)2.56130837
58Neurofibrillary tangles (HP:0002185)2.55831551
59Craniofacial dystonia (HP:0012179)2.51488622
60Excessive salivation (HP:0003781)2.50408547
61Drooling (HP:0002307)2.50408547
62Diplopia (HP:0000651)2.50155858
63Abnormality of binocular vision (HP:0011514)2.50155858
64Obstructive sleep apnea (HP:0002870)2.40160470
65Peripheral hypomyelination (HP:0007182)2.37204634
66Bundle branch block (HP:0011710)2.37034839
67Epileptiform EEG discharges (HP:0011182)2.29277447
68Status epilepticus (HP:0002133)2.28932466
69Progressive inability to walk (HP:0002505)2.26619664
70Insomnia (HP:0100785)2.26436034
71CNS hypomyelination (HP:0003429)2.25410459
72Ankyloglossia (HP:0010296)2.21468523
73Morphological abnormality of the pyramidal tract (HP:0002062)2.21348229
74Choreoathetosis (HP:0001266)2.20720615
75EEG with generalized epileptiform discharges (HP:0011198)2.20475595
76Lower limb muscle weakness (HP:0007340)2.16664053
77Fetal akinesia sequence (HP:0001989)2.15235256
78Termporal pattern (HP:0011008)2.14588451
79Insidious onset (HP:0003587)2.14588451
80Hypsarrhythmia (HP:0002521)2.13010623
81Resting tremor (HP:0002322)2.12826091
82Abnormality of the corticospinal tract (HP:0002492)2.11604868
83Amyotrophic lateral sclerosis (HP:0007354)2.10125173
84Lower limb asymmetry (HP:0100559)2.09595023
85Absent speech (HP:0001344)2.09222571
86Incomplete penetrance (HP:0003829)2.09136923
87Generalized myoclonic seizures (HP:0002123)2.08348610
88Lower limb amyotrophy (HP:0007210)2.05528124
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04322332
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.04322332
91Clonus (HP:0002169)2.02530157
92Gait ataxia (HP:0002066)1.98683201
93Abnormality of saccadic eye movements (HP:0000570)1.93249496
94Apathy (HP:0000741)1.92065740
95Abnormality of the periventricular white matter (HP:0002518)1.91057422
96Abnormal EKG (HP:0003115)1.89451675
97Neuronal loss in central nervous system (HP:0002529)1.89431149
98Increased circulating renin level (HP:0000848)1.88237705
99Delusions (HP:0000746)1.86726186
100Rapidly progressive (HP:0003678)1.82908405
101Inability to walk (HP:0002540)1.82065476
102Rigidity (HP:0002063)1.81993357
103Inappropriate behavior (HP:0000719)1.80555947
104Aplasia involving bones of the upper limbs (HP:0009823)1.79660996
105Aplasia of the phalanges of the hand (HP:0009802)1.79660996
106Aplasia involving bones of the extremities (HP:0009825)1.79660996
107Intellectual disability, profound (HP:0002187)1.78936959
108Agitation (HP:0000713)1.77521601
109Unsteady gait (HP:0002317)1.77135385
110Memory impairment (HP:0002354)1.76444995
111Spastic tetraplegia (HP:0002510)1.75449847
112Tetraplegia (HP:0002445)1.70796091
113Limb dystonia (HP:0002451)1.70786200
114Spinal canal stenosis (HP:0003416)1.67870877
115Spastic tetraparesis (HP:0001285)1.67110207
116Anosmia (HP:0000458)1.66974139
117Diminished motivation (HP:0000745)1.66011764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.27010194
2NTRK34.41187153
3MAP3K94.09584149
4DAPK23.07090253
5PRKD32.81234941
6MARK12.68940877
7MINK12.65977506
8MAP3K42.53414952
9KSR22.52855683
10PAK62.50086062
11CAMKK12.26832650
12RIPK42.03406632
13NTRK22.02531004
14MAP2K71.93437588
15NTRK11.85985549
16DAPK11.77672407
17KSR11.76628255
18CDK51.62939898
19MAP2K41.59774243
20PRPF4B1.58969205
21STK381.51649592
22MAP3K131.46772931
23ARAF1.44659000
24TYRO31.44138879
25SIK21.39373555
26MAP3K21.34571650
27TAOK11.32381016
28FES1.31269954
29MAP3K121.30562319
30PLK21.25105660
31TNIK1.24380994
32GRK51.23912779
33PRKCG1.20737996
34CDK191.16543194
35CAMK11.12810558
36CAMKK21.12600575
37RAF11.05934521
38UHMK11.03438146
39MAPK130.99334551
40STK110.98926885
41ALK0.98617546
42PTK2B0.96042897
43PNCK0.93491678
44CDK150.92839995
45PRKCH0.92266936
46CDK180.92260103
47LATS20.91872182
48CAMK2A0.88587592
49RIPK10.86091546
50CDK140.85696471
51PDK10.84409996
52CDK11A0.81153949
53RET0.80268781
54PHKG10.80151506
55PHKG20.80151506
56MAPK120.79145494
57PINK10.78823891
58CASK0.77856444
59SGK4940.77062046
60SGK2230.77062046
61PKN10.76456675
62PDPK10.73946083
63BRAF0.73236176
64MARK20.73173831
65CAMK2B0.72886610
66BMPR20.70594121
67PAK30.69433043
68LMTK20.69167077
69SGK10.69094240
70MAP3K110.68869285
71SGK30.65354948
72WNK10.64936117
73MAP3K10.63072585
74SGK20.61760376
75DYRK1A0.60741915
76LIMK10.58900759
77CAMK40.58261145
78BRSK10.58172083
79MAP3K70.57879895
80FGFR20.54376187
81NEK10.54261052
82DAPK30.53223975
83NEK60.52022840
84RPS6KA30.51930380
85PRKCZ0.51780242
86DMPK0.51515766
87FYN0.48827171
88OXSR10.48732909
89CSNK1G20.46098140
90TNK20.45082928
91MAPK100.43448357
92CDC42BPA0.42105598
93MAP2K10.41445454
94CAMK1G0.40616510
95SCYL20.39916179
96ROCK20.39253365
97ERBB20.35991615
98CAMK2G0.35366001
99FGR0.35300584
100CAMK1D0.34825338
101TESK10.34361710
102DDR20.33511843
103NME10.33128663
104PRKCA0.32989935
105PRKCE0.31869614
106ICK0.31258855
107CAMK2D0.31164954
108MAPK80.30372112
109FER0.29587099
110DYRK20.29422042
111PRKCB0.29365393
112PRKD20.28949984
113RPS6KA20.27972454
114PRKG20.27104871
115CCNB10.26894583
116CSNK1E0.26551243
117PRKACA0.26421889
118PRKG10.26421746
119MAP2K60.25913969
120IRAK20.24702850

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.41086496
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09412793
3Long-term potentiation_Homo sapiens_hsa047202.84597521
4Circadian entrainment_Homo sapiens_hsa047132.79940919
5* Olfactory transduction_Homo sapiens_hsa047402.71702058
6Glutamatergic synapse_Homo sapiens_hsa047242.68789448
7Amphetamine addiction_Homo sapiens_hsa050312.57231053
8GABAergic synapse_Homo sapiens_hsa047272.56782919
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55340098
10Morphine addiction_Homo sapiens_hsa050322.47246382
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28262182
12Salivary secretion_Homo sapiens_hsa049702.28006257
13Dopaminergic synapse_Homo sapiens_hsa047282.15275864
14Gastric acid secretion_Homo sapiens_hsa049712.04566348
15Aldosterone synthesis and secretion_Homo sapiens_hsa049252.03127648
16Insulin secretion_Homo sapiens_hsa049112.02124543
17Cholinergic synapse_Homo sapiens_hsa047252.01779779
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78812289
19Oxytocin signaling pathway_Homo sapiens_hsa049211.77227947
20Long-term depression_Homo sapiens_hsa047301.67604438
21Renin secretion_Homo sapiens_hsa049241.65425003
22Cocaine addiction_Homo sapiens_hsa050301.64341789
23* Calcium signaling pathway_Homo sapiens_hsa040201.59823241
24GnRH signaling pathway_Homo sapiens_hsa049121.56725454
25Taste transduction_Homo sapiens_hsa047421.53123806
26Nitrogen metabolism_Homo sapiens_hsa009101.51193711
27Vitamin B6 metabolism_Homo sapiens_hsa007501.51152890
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49886526
29Serotonergic synapse_Homo sapiens_hsa047261.44638114
30Gap junction_Homo sapiens_hsa045401.39293267
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36290077
32Glioma_Homo sapiens_hsa052141.33649949
33cAMP signaling pathway_Homo sapiens_hsa040241.32911207
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27520362
35Type II diabetes mellitus_Homo sapiens_hsa049301.26623913
36Estrogen signaling pathway_Homo sapiens_hsa049151.21929975
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19839204
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15778420
39Melanogenesis_Homo sapiens_hsa049161.10946983
40ErbB signaling pathway_Homo sapiens_hsa040121.08895264
41Axon guidance_Homo sapiens_hsa043601.07277461
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03704056
43* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02949200
44Oocyte meiosis_Homo sapiens_hsa041140.97287808
45Collecting duct acid secretion_Homo sapiens_hsa049660.96904025
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.96836399
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.96436041
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94593858
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93565946
50Pancreatic secretion_Homo sapiens_hsa049720.90222330
51Dorso-ventral axis formation_Homo sapiens_hsa043200.87985752
52Thyroid hormone synthesis_Homo sapiens_hsa049180.84092388
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81652217
54VEGF signaling pathway_Homo sapiens_hsa043700.80546217
55Cardiac muscle contraction_Homo sapiens_hsa042600.80340439
56Choline metabolism in cancer_Homo sapiens_hsa052310.78335576
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76221691
58Dilated cardiomyopathy_Homo sapiens_hsa054140.74661993
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72844859
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.72688106
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72380121
62MAPK signaling pathway_Homo sapiens_hsa040100.71533772
63mTOR signaling pathway_Homo sapiens_hsa041500.64538074
64Rap1 signaling pathway_Homo sapiens_hsa040150.63783765
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63306755
66Glucagon signaling pathway_Homo sapiens_hsa049220.62329281
67Non-small cell lung cancer_Homo sapiens_hsa052230.60158494
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.59950056
69Vibrio cholerae infection_Homo sapiens_hsa051100.59822611
70Bile secretion_Homo sapiens_hsa049760.58482471
71Endocytosis_Homo sapiens_hsa041440.57264938
72Ras signaling pathway_Homo sapiens_hsa040140.57227854
73Phototransduction_Homo sapiens_hsa047440.54414185
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53028426
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49988814
76Alcoholism_Homo sapiens_hsa050340.49765313
77Endometrial cancer_Homo sapiens_hsa052130.49638320
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49375647
79Inositol phosphate metabolism_Homo sapiens_hsa005620.48840784
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47739322
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46748591
82Type I diabetes mellitus_Homo sapiens_hsa049400.44528402
83Prion diseases_Homo sapiens_hsa050200.43872176
84African trypanosomiasis_Homo sapiens_hsa051430.43708336
85Wnt signaling pathway_Homo sapiens_hsa043100.42342626
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41902700
87Chemokine signaling pathway_Homo sapiens_hsa040620.41892218
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41850821
89Renal cell carcinoma_Homo sapiens_hsa052110.41440081
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38947302
91Insulin signaling pathway_Homo sapiens_hsa049100.38917315
92Alzheimers disease_Homo sapiens_hsa050100.38900257
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37872072
94Arginine and proline metabolism_Homo sapiens_hsa003300.37630556
95Circadian rhythm_Homo sapiens_hsa047100.34502533
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34083865
97Ovarian steroidogenesis_Homo sapiens_hsa049130.32808354
98Arginine biosynthesis_Homo sapiens_hsa002200.32208426
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32115258
100Mineral absorption_Homo sapiens_hsa049780.31440556
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31011902
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29279285
103Platelet activation_Homo sapiens_hsa046110.29209447
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28669487
105AMPK signaling pathway_Homo sapiens_hsa041520.28634511
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28057303
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27904983
108Tight junction_Homo sapiens_hsa045300.25521097
109Fatty acid biosynthesis_Homo sapiens_hsa000610.25295652
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25154117
111Hippo signaling pathway_Homo sapiens_hsa043900.19604859
112HIF-1 signaling pathway_Homo sapiens_hsa040660.18809136

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