SLC8A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)8.39882377
2sarcomere organization (GO:0045214)7.35769903
3myofibril assembly (GO:0030239)6.96158318
4negative regulation of potassium ion transmembrane transport (GO:1901380)6.73747284
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.70534247
6* regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.33447532
7* cardiac muscle contraction (GO:0060048)6.16722006
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.07613217
9* cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.99124656
10* regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.79443794
11regulation of sarcomere organization (GO:0060297)5.74301655
12cardiac muscle hypertrophy (GO:0003300)5.74090848
13* regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.65419510
14muscle filament sliding (GO:0030049)5.59836521
15actin-myosin filament sliding (GO:0033275)5.59836521
16cardiac muscle tissue morphogenesis (GO:0055008)5.45615050
17striated muscle hypertrophy (GO:0014897)5.41228236
18* cardiac muscle cell development (GO:0055013)5.34316604
19ventricular cardiac muscle cell action potential (GO:0086005)5.29366340
20adult heart development (GO:0007512)5.29035404
21ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.26391037
22regulation of actin filament-based movement (GO:1903115)5.23899285
23* cell communication by electrical coupling (GO:0010644)5.22259156
24regulation of relaxation of muscle (GO:1901077)5.07790337
25actomyosin structure organization (GO:0031032)5.04440868
26regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.02870825
27* cardiac cell development (GO:0055006)4.98312318
28regulation of membrane repolarization (GO:0060306)4.95468840
29* cell communication involved in cardiac conduction (GO:0086065)4.95418503
30muscle hypertrophy (GO:0014896)4.81691497
31muscle tissue morphogenesis (GO:0060415)4.81567656
32actin-mediated cell contraction (GO:0070252)4.71207473
33negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.66906486
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.64412743
35tricarboxylic acid cycle (GO:0006099)4.63397669
36* striated muscle contraction (GO:0006941)4.51398811
37regulation of cell communication by electrical coupling (GO:0010649)4.48957648
38* regulation of the force of heart contraction (GO:0002026)4.38590854
39* regulation of striated muscle contraction (GO:0006942)4.35635661
40cardiac ventricle formation (GO:0003211)4.30221173
41membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.23524763
42heart trabecula formation (GO:0060347)4.20975786
43positive regulation of cardiac muscle cell differentiation (GO:2000727)4.19974520
44bundle of His cell to Purkinje myocyte communication (GO:0086069)4.19494680
45heart contraction (GO:0060047)4.16732475
46heart process (GO:0003015)4.16732475
47positive regulation of potassium ion transmembrane transport (GO:1901381)4.16343099
48cardiac muscle cell action potential (GO:0086001)4.09232689
49cardiac muscle adaptation (GO:0014887)4.08308396
50cardiac muscle hypertrophy in response to stress (GO:0014898)4.08308396
51muscle hypertrophy in response to stress (GO:0003299)4.08308396
52plasma membrane repair (GO:0001778)4.07217259
53cardiac muscle cell action potential involved in contraction (GO:0086002)4.05951569
54cardiac conduction (GO:0061337)4.05125284
55regulation of cardioblast differentiation (GO:0051890)4.02093569
56sarcoplasmic reticulum calcium ion transport (GO:0070296)3.97815985
57regulation of heart rate by cardiac conduction (GO:0086091)3.93722468
58* membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93645012
59carnitine shuttle (GO:0006853)3.92585728
60negative regulation of potassium ion transport (GO:0043267)3.92510474
61atrial septum morphogenesis (GO:0060413)3.87463026
62detection of calcium ion (GO:0005513)3.83098945
63* regulation of cardiac muscle contraction (GO:0055117)3.82129168
64positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.78781211
65regulation of cardiac muscle cell contraction (GO:0086004)3.78009121
66cellular potassium ion homeostasis (GO:0030007)3.77683548
67membrane repolarization during action potential (GO:0086011)3.77638483
68regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.77244163
69* regulation of heart rate (GO:0002027)3.75659743
70positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.73136761
71negative regulation of striated muscle cell apoptotic process (GO:0010664)3.69856575
72actin filament-based movement (GO:0030048)3.69249886
73regulation of skeletal muscle contraction (GO:0014819)3.63130043
74cardiac chamber formation (GO:0003207)3.61246508
75potassium ion export (GO:0071435)3.60379052
76* relaxation of cardiac muscle (GO:0055119)3.55355788
77positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.50842071
78adrenergic receptor signaling pathway (GO:0071875)3.50519218
79* negative regulation of cytosolic calcium ion concentration (GO:0051481)3.49954773
80* regulation of heart contraction (GO:0008016)3.49722732
81regulation of acyl-CoA biosynthetic process (GO:0050812)3.49226991
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.46278582
83negative regulation of protein localization to cell surface (GO:2000009)3.43766949
84outflow tract septum morphogenesis (GO:0003148)3.36675768
85regulation of calcium ion transmembrane transporter activity (GO:1901019)3.36114259
86regulation of calcium ion transmembrane transport (GO:1903169)3.36114259
87regulation of cofactor metabolic process (GO:0051193)3.35940481
88regulation of coenzyme metabolic process (GO:0051196)3.35940481
89fatty acid transmembrane transport (GO:1902001)3.34669563
90regulation of potassium ion transmembrane transport (GO:1901379)3.33827783
91regulation of potassium ion transmembrane transporter activity (GO:1901016)3.31042744
92positive regulation of sodium ion transport (GO:0010765)3.29726137
93membrane repolarization (GO:0086009)3.28709953
94ventricular cardiac muscle cell development (GO:0055015)3.28073708
95regulation of voltage-gated calcium channel activity (GO:1901385)3.25925167
96cellular response to epinephrine stimulus (GO:0071872)3.25147613
97positive regulation of potassium ion transport (GO:0043268)3.24195215
98positive regulation of cation channel activity (GO:2001259)3.16514783
99response to epinephrine (GO:0071871)3.15329164
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12851818
101gamma-aminobutyric acid signaling pathway (GO:0007214)3.11086932
102* relaxation of muscle (GO:0090075)3.10310039
103ionotropic glutamate receptor signaling pathway (GO:0035235)3.08528108
104regulation of ATP catabolic process (GO:1903289)3.06786869
105regulation of ATPase activity (GO:0043462)3.06786869
106positive regulation of muscle hypertrophy (GO:0014742)3.04424264
107positive regulation of cardiac muscle hypertrophy (GO:0010613)3.04424264
108regulation of cardiac muscle cell apoptotic process (GO:0010665)3.04285242
109* regulation of muscle contraction (GO:0006937)3.03929346
110sequestering of extracellular ligand from receptor (GO:0035581)3.03658552
111* sodium ion export (GO:0071436)3.03188388
112positive regulation of cardiac muscle tissue growth (GO:0055023)3.01901753
113positive regulation of ATP catabolic process (GO:1903291)3.01783735
114positive regulation of ATPase activity (GO:0032781)3.01783735
115positive regulation of heart contraction (GO:0045823)3.00832350
116regulation of cardiac muscle cell differentiation (GO:2000725)3.00209755
117regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.99435274
118positive regulation of heart rate (GO:0010460)2.98916932
119cardiac right ventricle morphogenesis (GO:0003215)2.97409657
120regulation of striated muscle cell apoptotic process (GO:0010662)2.96014373
121positive regulation of cardiac muscle tissue development (GO:0055025)2.92718719
122positive regulation of sodium ion transmembrane transport (GO:1902307)2.92635708
123regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.92589149
124venous blood vessel morphogenesis (GO:0048845)2.91160731
125negative regulation of heart rate (GO:0010459)2.88730090
126* striated muscle cell development (GO:0055002)2.87947697
127positive regulation of ion transmembrane transporter activity (GO:0032414)2.87095734
128presynaptic membrane assembly (GO:0097105)2.84576679
129potassium ion import (GO:0010107)2.83319095
130* membrane depolarization during action potential (GO:0086010)2.82190457
131negative regulation of hormone biosynthetic process (GO:0032353)2.79623699
132startle response (GO:0001964)2.77895881
133positive regulation of heart growth (GO:0060421)2.77697877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EP300_21415370_ChIP-Seq_HL-1_Mouse3.81889915
2EZH2_22144423_ChIP-Seq_EOC_Human3.54853967
3GBX2_23144817_ChIP-Seq_PC3_Human2.80635649
4* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56467987
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42473847
6DROSHA_22980978_ChIP-Seq_HELA_Human2.32003244
7* TBX20_22328084_ChIP-Seq_HEART_Mouse2.31911371
8* TBX20_22080862_ChIP-Seq_HEART_Mouse2.31911371
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.29737582
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15523764
11* MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.07361548
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.06515879
13* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99164788
14* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99017222
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.95276079
16VDR_22108803_ChIP-Seq_LS180_Human1.93636591
17* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91455886
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89738787
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89738787
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.88528220
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88064016
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83986786
23IGF1R_20145208_ChIP-Seq_DFB_Human1.80608677
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77358816
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.76879759
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69690764
27NR3C1_23031785_ChIP-Seq_PC12_Mouse1.68036792
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66922222
29FUS_26573619_Chip-Seq_HEK293_Human1.66817301
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66325119
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64913874
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.62215269
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61695556
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.60551600
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58906876
36* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57817815
37* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55239075
38* RNF2_27304074_Chip-Seq_ESCs_Mouse1.54347180
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.53366384
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.53028378
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49475338
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.45362432
43REST_21632747_ChIP-Seq_MESCs_Mouse1.44586507
44* SOX2_21211035_ChIP-Seq_LN229_Gbm1.44342195
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.44321959
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43794116
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43403707
48ZNF274_21170338_ChIP-Seq_K562_Hela1.41196636
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40355262
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40355262
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.39867364
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38430740
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38140093
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38140093
55* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36754905
56SMAD3_21741376_ChIP-Seq_HESCs_Human1.36496278
57AHR_22903824_ChIP-Seq_MCF-7_Human1.34732463
58* AR_19668381_ChIP-Seq_PC3_Human1.33740957
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33413955
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33169632
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29235346
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.26470201
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25603583
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24507351
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.24491963
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.24121265
67* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.23783394
68* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23160526
69* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23030471
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23002144
71* SMAD4_21741376_ChIP-Seq_HESCs_Human1.22072924
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21748081
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.21622491
74GATA1_22025678_ChIP-Seq_K562_Human1.21040991
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20436572
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19911196
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19199720
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19172901
79TP53_18474530_ChIP-ChIP_U2OS_Human1.18265110
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17356414
81TP53_16413492_ChIP-PET_HCT116_Human1.16988477
82RNF2_27304074_Chip-Seq_NSC_Mouse1.16798018
83* REST_18959480_ChIP-ChIP_MESCs_Mouse1.16194943
84ZNF263_19887448_ChIP-Seq_K562_Human1.15708970
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14258580
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13298098
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12909239
88* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11723780
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11493664
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11128007
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10145263
92AR_21572438_ChIP-Seq_LNCaP_Human1.10018020
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09784230
94WT1_19549856_ChIP-ChIP_CCG9911_Human1.09585132
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09321570
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08928949
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08270074
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07865055
99RUNX2_22187159_ChIP-Seq_PCA_Human1.07781092
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.07159339
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.06569162
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.06367244
103* TCF4_23295773_ChIP-Seq_U87_Human1.05685239
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05159494
105KDM2B_26808549_Chip-Seq_REH_Human1.05133411
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.04884027
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04351530
108BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04055190
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.03879672
110STAT3_23295773_ChIP-Seq_U87_Human1.03714170
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03696248
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03599620
113BCAT_22108803_ChIP-Seq_LS180_Human1.03187307
114* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01479400
115P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97933184
116CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97453238
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97291344
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95763449
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95741912
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95696369
121P300_19829295_ChIP-Seq_ESCs_Human0.93979700
122AR_25329375_ChIP-Seq_VCAP_Human0.92229550
123* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91725149
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90569248
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90488558
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89593357
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88815928
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88414498
129TAF15_26573619_Chip-Seq_HEK293_Human0.88178859
130KDM2B_26808549_Chip-Seq_K562_Human0.87497912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004084_abnormal_cardiac_muscle6.08066747
2MP0002837_dystrophic_cardiac_calcinosis5.96753155
3MP0004215_abnormal_myocardial_fiber5.04735745
4* MP0004036_abnormal_muscle_relaxation4.14403357
5MP0000751_myopathy4.06699570
6MP0005330_cardiomyopathy3.88128776
7MP0003646_muscle_fatigue3.45269690
8* MP0008775_abnormal_heart_ventricle3.36927967
9* MP0002972_abnormal_cardiac_muscle3.33070558
10MP0000749_muscle_degeneration3.27711674
11MP0003137_abnormal_impulse_conducting3.18280128
12MP0004510_myositis2.92998257
13* MP0005620_abnormal_muscle_contractility2.78626990
14* MP0004087_abnormal_muscle_fiber2.72517491
15* MP0010630_abnormal_cardiac_muscle2.57322490
16* MP0004085_abnormal_heartbeat2.53702458
17* MP0005385_cardiovascular_system_phenoty2.48346725
18* MP0001544_abnormal_cardiovascular_syste2.48346725
19MP0004145_abnormal_muscle_electrophysio2.44018217
20MP0004484_altered_response_of2.41213538
21MP0006138_congestive_heart_failure2.39879372
22MP0000569_abnormal_digit_pigmentation2.37178392
23MP0003828_pulmonary_edema2.33693924
24MP0004233_abnormal_muscle_weight2.32204529
25MP0005423_abnormal_somatic_nervous2.18418230
26MP0002106_abnormal_muscle_physiology2.14056858
27MP0004130_abnormal_muscle_cell2.09033663
28MP0002127_abnormal_cardiovascular_syste1.88952495
29MP0002269_muscular_atrophy1.88286819
30MP0000750_abnormal_muscle_regeneration1.81198796
31MP0005369_muscle_phenotype1.71088725
32* MP0003221_abnormal_cardiomyocyte_apopto1.67704542
33MP0002102_abnormal_ear_morphology1.66896826
34MP0003950_abnormal_plasma_membrane1.62401871
35MP0003567_abnormal_fetal_cardiomyocyte1.53398276
36MP0004859_abnormal_synaptic_plasticity1.53277727
37MP0002822_catalepsy1.49802555
38MP0000759_abnormal_skeletal_muscle1.41644493
39MP0000747_muscle_weakness1.41344660
40MP0001501_abnormal_sleep_pattern1.36384266
41MP0002332_abnormal_exercise_endurance1.34721390
42MP0002090_abnormal_vision1.27029855
43MP0002234_abnormal_pharynx_morphology1.26846032
44MP0010386_abnormal_urinary_bladder1.22741431
45MP0003122_maternal_imprinting1.21421655
46MP0002909_abnormal_adrenal_gland1.17826730
47MP0003045_fibrosis1.17354620
48* MP0000266_abnormal_heart_morphology1.17310651
49MP0010368_abnormal_lymphatic_system1.17047523
50MP0001970_abnormal_pain_threshold1.16468387
51MP0006276_abnormal_autonomic_nervous1.15347858
52MP0000778_abnormal_nervous_system1.11150987
53MP0005551_abnormal_eye_electrophysiolog1.10426735
54MP0001440_abnormal_grooming_behavior1.09703000
55MP0001968_abnormal_touch/_nociception1.08154396
56MP0003879_abnormal_hair_cell1.07549108
57MP0000462_abnormal_digestive_system1.00881686
58MP0005623_abnormal_meninges_morphology1.00204039
59MP0000230_abnormal_systemic_arterial0.97691333
60MP0005451_abnormal_body_composition0.96287564
61MP0003635_abnormal_synaptic_transmissio0.95983038
62MP0009780_abnormal_chondrocyte_physiolo0.95235935
63MP0006072_abnormal_retinal_apoptosis0.94958998
64MP0002638_abnormal_pupillary_reflex0.94675065
65MP0003279_aneurysm0.93237822
66MP0008874_decreased_physiological_sensi0.90013927
67MP0006036_abnormal_mitochondrial_physio0.88627727
68MP0001299_abnormal_eye_distance/0.83076431
69MP0002882_abnormal_neuron_morphology0.81204244
70MP0002733_abnormal_thermal_nociception0.80878060
71MP0005165_increased_susceptibility_to0.80180579
72MP0005670_abnormal_white_adipose0.80045802
73MP0002066_abnormal_motor_capabilities/c0.79000557
74MP0004272_abnormal_basement_membrane0.77776348
75MP0004142_abnormal_muscle_tone0.77025104
76MP0003690_abnormal_glial_cell0.76737588
77MP0002184_abnormal_innervation0.75624038
78MP0002063_abnormal_learning/memory/cond0.75586636
79MP0004811_abnormal_neuron_physiology0.75365523
80MP0000013_abnormal_adipose_tissue0.74410446
81MP0005595_abnormal_vascular_smooth0.74401141
82MP0005248_abnormal_Harderian_gland0.74221375
83MP0009046_muscle_twitch0.73526490
84MP0003787_abnormal_imprinting0.73406870
85MP0003566_abnormal_cell_adhesion0.72165730
86MP0005503_abnormal_tendon_morphology0.71799495
87MP0002557_abnormal_social/conspecific_i0.71682686
88MP0004742_abnormal_vestibular_system0.71099804
89MP0004924_abnormal_behavior0.70939280
90MP0005386_behavior/neurological_phenoty0.70939280
91MP0005666_abnormal_adipose_tissue0.70302160
92MP0003329_amyloid_beta_deposits0.69660082
93MP0003631_nervous_system_phenotype0.69505191
94MP0002064_seizures0.68464378
95* MP0002128_abnormal_blood_circulation0.68369906
96MP0000955_abnormal_spinal_cord0.67821259
97MP0009745_abnormal_behavioral_response0.67065606
98MP0009384_cardiac_valve_regurgitation0.63734202
99MP0004858_abnormal_nervous_system0.63475649
100MP0001529_abnormal_vocalization0.62014220
101MP0002108_abnormal_muscle_morphology0.59545003
102MP0003880_abnormal_central_pattern0.59196676
103MP0003890_abnormal_embryonic-extraembry0.58740927
104MP0000343_altered_response_to0.58341384
105MP0001986_abnormal_taste_sensitivity0.57278515
106MP0003121_genomic_imprinting0.55594794
107MP0008961_abnormal_basal_metabolism0.54545227
108MP0002229_neurodegeneration0.54446363
109MP0002272_abnormal_nervous_system0.54416188
110* MP0002925_abnormal_cardiovascular_devel0.54151551
111MP0001984_abnormal_olfaction0.53797693
112MP0004270_analgesia0.53717322
113MP0002067_abnormal_sensory_capabilities0.53205693
114MP0000920_abnormal_myelination0.53017991
115MP0001963_abnormal_hearing_physiology0.52459978
116MP0001879_abnormal_lymphatic_vessel0.52358800
117MP0001486_abnormal_startle_reflex0.50932884
118MP0001502_abnormal_circadian_rhythm0.50429721
119MP0005375_adipose_tissue_phenotype0.49925163
120MP0002734_abnormal_mechanical_nocicepti0.49806555
121MP0005253_abnormal_eye_physiology0.49415844
122* MP0006035_abnormal_mitochondrial_morpho0.48836471
123MP0008569_lethality_at_weaning0.48632777
124MP0005266_abnormal_metabolism0.48530214
125MP0000767_abnormal_smooth_muscle0.47428398
126MP0005187_abnormal_penis_morphology0.47341348
127MP0003633_abnormal_nervous_system0.45919138
128MP0002735_abnormal_chemical_nociception0.44133309
129MP0003172_abnormal_lysosome_physiology0.43332446
130MP0002078_abnormal_glucose_homeostasis0.42913677
131MP0000003_abnormal_adipose_tissue0.42396240
132MP0004043_abnormal_pH_regulation0.41882112
133MP0003948_abnormal_gas_homeostasis0.41269273
134* MP0001784_abnormal_fluid_regulation0.40389462
135MP0003705_abnormal_hypodermis_morpholog0.38620426
136MP0002572_abnormal_emotion/affect_behav0.38103920
137MP0005535_abnormal_body_temperature0.37616678

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)9.08178642
2Atrial fibrillation (HP:0005110)6.80099118
3Ventricular tachycardia (HP:0004756)6.39796981
4Primary atrial arrhythmia (HP:0001692)6.38659976
5Supraventricular tachycardia (HP:0004755)6.12113909
6Supraventricular arrhythmia (HP:0005115)6.00429313
7Syncope (HP:0001279)5.96949784
8Exercise-induced muscle cramps (HP:0003710)5.61128902
9Prolonged QT interval (HP:0001657)5.46107061
10Subaortic stenosis (HP:0001682)5.44866414
11Abnormality of the left ventricular outflow tract (HP:0011103)5.44866414
12Lipoatrophy (HP:0100578)5.26527017
13Calf muscle hypertrophy (HP:0008981)5.24888424
14Abnormality of the calf musculature (HP:0001430)5.02639949
15Ventricular arrhythmia (HP:0004308)4.87908054
16Exercise-induced myalgia (HP:0003738)4.86687545
17Ventricular fibrillation (HP:0001663)4.80181842
18Right ventricular cardiomyopathy (HP:0011663)4.76316693
19Muscle hypertrophy of the lower extremities (HP:0008968)4.61395702
20Focal motor seizures (HP:0011153)4.59075604
21Atonic seizures (HP:0010819)4.47472604
22Febrile seizures (HP:0002373)4.39151276
23Palpitations (HP:0001962)4.35775937
24Dilated cardiomyopathy (HP:0001644)4.28890370
25Myoglobinuria (HP:0002913)4.18594177
26Muscle fiber splitting (HP:0003555)4.11944493
27Abnormal EKG (HP:0003115)4.09445026
28Asymmetric septal hypertrophy (HP:0001670)4.07404937
29Bundle branch block (HP:0011710)4.02583828
30Hyporeflexia of lower limbs (HP:0002600)3.96034258
31EMG: myopathic abnormalities (HP:0003458)3.78731246
32Hip contracture (HP:0003273)3.72039401
33Heart block (HP:0012722)3.38824936
34Atrioventricular block (HP:0001678)3.38688835
35Focal seizures (HP:0007359)3.37666535
36Left ventricular hypertrophy (HP:0001712)3.36132089
37Myokymia (HP:0002411)3.32824233
38Broad-based gait (HP:0002136)3.31716686
39Hyperventilation (HP:0002883)3.30879062
40Action tremor (HP:0002345)3.28542105
41Abnormal atrioventricular conduction (HP:0005150)3.13032729
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.98437438
43Progressive cerebellar ataxia (HP:0002073)2.88562977
44Limited hip movement (HP:0008800)2.88023900
45Rhabdomyolysis (HP:0003201)2.81705342
46Pheochromocytoma (HP:0002666)2.78846141
47Central scotoma (HP:0000603)2.77431055
48Dialeptic seizures (HP:0011146)2.77398151
49Ragged-red muscle fibers (HP:0003200)2.75912807
50Gaze-evoked nystagmus (HP:0000640)2.75671249
51Absence seizures (HP:0002121)2.73670509
52Aplasia of the musculature (HP:0100854)2.60897138
53Congenital stationary night blindness (HP:0007642)2.57640307
54Drooling (HP:0002307)2.56480833
55Sudden cardiac death (HP:0001645)2.48368346
56Congenital malformation of the right heart (HP:0011723)2.48187793
57Double outlet right ventricle (HP:0001719)2.48187793
58Neuroendocrine neoplasm (HP:0100634)2.46917825
59Fetal akinesia sequence (HP:0001989)2.46592544
60Myotonia (HP:0002486)2.44271701
61Palmoplantar keratoderma (HP:0000982)2.42992990
62Excessive salivation (HP:0003781)2.38938163
63Truncal ataxia (HP:0002078)2.34981946
64Generalized tonic-clonic seizures (HP:0002069)2.33209787
65Increased connective tissue (HP:0009025)2.30840127
66Difficulty running (HP:0009046)2.24647229
67Neoplasm of the adrenal gland (HP:0100631)2.23266888
68Hip dysplasia (HP:0001385)2.22847034
69Dysdiadochokinesis (HP:0002075)2.22086053
70Ketoacidosis (HP:0001993)2.21766057
71Lymphangioma (HP:0100764)2.20489400
72Papillary thyroid carcinoma (HP:0002895)2.20386128
73EMG: neuropathic changes (HP:0003445)2.18373729
74Diaphragmatic weakness (HP:0009113)2.17953875
75Hamartoma of the eye (HP:0010568)2.17113163
76Congestive heart failure (HP:0001635)2.15716146
77Type 1 muscle fiber predominance (HP:0003803)2.12694055
78Abnormality of the foot musculature (HP:0001436)2.08092066
79Patent foramen ovale (HP:0001655)2.07576907
80Dysmetric saccades (HP:0000641)2.06852356
81Conjunctival hamartoma (HP:0100780)2.05093376
82Scanning speech (HP:0002168)2.03262051
83Mildly elevated creatine phosphokinase (HP:0008180)2.01368056
84Rimmed vacuoles (HP:0003805)2.00430706
85Hypoglycemic coma (HP:0001325)1.97121308
86Neck muscle weakness (HP:0000467)1.96660146
87Urinary urgency (HP:0000012)1.96532170
88Postural instability (HP:0002172)1.93581135
89Scapular winging (HP:0003691)1.93011203
90Obstructive sleep apnea (HP:0002870)1.90989547
91Protruding tongue (HP:0010808)1.88775951
92Gowers sign (HP:0003391)1.88220992
93Knee flexion contracture (HP:0006380)1.87007418
94Generalized muscle weakness (HP:0003324)1.85284552
95Inability to walk (HP:0002540)1.84361079
96Steppage gait (HP:0003376)1.80779300
97Difficulty climbing stairs (HP:0003551)1.78986843
98Scotoma (HP:0000575)1.77681248
99Abnormality of the tricuspid valve (HP:0001702)1.77228921
100Lower limb muscle weakness (HP:0007340)1.77127058
101Bradycardia (HP:0001662)1.76799687
102Complete atrioventricular canal defect (HP:0001674)1.76727286
103Spinal muscular atrophy (HP:0007269)1.76116035
104Hypoplastic left heart (HP:0004383)1.75669865
105Epileptiform EEG discharges (HP:0011182)1.74859907
106Toxemia of pregnancy (HP:0100603)1.73619813
107Pancreatic islet-cell hyperplasia (HP:0004510)1.73025118
108Broad metatarsal (HP:0001783)1.72050144
109Decreased circulating renin level (HP:0003351)1.70569404
110Foot dorsiflexor weakness (HP:0009027)1.68515079
111Abnormal mitochondria in muscle tissue (HP:0008316)1.67800142
112Increased variability in muscle fiber diameter (HP:0003557)1.66731679
113Abnormality of the endocardium (HP:0004306)1.66116157
114Large for gestational age (HP:0001520)1.65698844
115Progressive inability to walk (HP:0002505)1.64633924
116Muscle stiffness (HP:0003552)1.64185874
117Papilledema (HP:0001085)1.63975223
118Hypoplastic ischia (HP:0003175)1.63861309
119Absent speech (HP:0001344)1.62849667
120Hepatic necrosis (HP:0002605)1.62152438
121Dysmetria (HP:0001310)1.60744285
122Hyperinsulinemic hypoglycemia (HP:0000825)1.59017967
123Abnormality of salivation (HP:0100755)1.57739665
124Tinnitus (HP:0000360)1.56833671
125Hemiplegia (HP:0002301)1.55814471
126Hemiparesis (HP:0001269)1.55800790
127Urinary bladder sphincter dysfunction (HP:0002839)1.54596231
128Atrioventricular canal defect (HP:0006695)1.54351874
129Vitreoretinal degeneration (HP:0000655)1.53673811
130Limb-girdle muscle atrophy (HP:0003797)1.52176770
131Pulmonary artery stenosis (HP:0004415)1.52037109
132Bicuspid aortic valve (HP:0001647)1.51877076
133Genetic anticipation (HP:0003743)1.51404463
134Impaired vibration sensation in the lower limbs (HP:0002166)1.51311972
135Lower limb amyotrophy (HP:0007210)1.50902253
136Distal lower limb muscle weakness (HP:0009053)1.50673783
137Muscular dystrophy (HP:0003560)1.50581170
138Poor eye contact (HP:0000817)1.50324536
139Neoplasm of the peripheral nervous system (HP:0100007)1.50060957
140Athetosis (HP:0002305)1.49225626
141Aneurysm (HP:0002617)1.48866589
142Hyperglycemia (HP:0003074)1.47757245
143Subacute progressive viral hepatitis (HP:0006572)1.47283711
144Cerebral aneurysm (HP:0004944)1.47131229
145Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.47058219
146Childhood onset (HP:0011463)1.47015368
147Preauricular pit (HP:0004467)1.46986085
148Periauricular skin pits (HP:0100277)1.46986085
149Acute necrotizing encephalopathy (HP:0006965)1.46693273
150Epileptic encephalopathy (HP:0200134)1.46420014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.29520536
2PKN23.84654016
3MYLK3.56728622
4PHKG23.49587880
5PHKG13.49587880
6CASK3.32548158
7DMPK3.23756349
8LMTK23.11501022
9TTN2.92449289
10STK242.65089749
11NEK12.64384567
12FRK2.56809538
13PDK42.23470766
14PDK32.23470766
15PIK3CA1.94675250
16INSRR1.82491270
17TRIB31.82331556
18MARK11.76473712
19CDC42BPA1.75138069
20RIPK11.71299003
21AKT31.70680253
22TIE11.60139246
23PAK31.59321434
24CAMK2D1.39432615
25ILK1.37729628
26MAP3K71.36631944
27TNIK1.34275575
28ZAK1.27579747
29EPHA31.26782808
30ROCK11.26621870
31GRK71.24681129
32MAP2K71.19273880
33STK381.13821369
34PDK21.12617003
35PRKD11.11680995
36CAMK2B1.10680183
37PINK11.08398620
38DAPK31.07673747
39MAP3K121.05220153
40WNK41.04318145
41PRKAA11.01343313
42MINK10.99919431
43PAK60.98894396
44CAMK10.97114029
45MAP3K40.95040158
46STK38L0.92224210
47EPHA40.91091471
48PTK2B0.88721436
49FLT30.88659840
50CAMK2A0.88168875
51CCNB10.86520025
52PKN10.84518347
53MAPK120.83439785
54WNK30.83378421
55CAMK40.81789879
56MUSK0.80262814
57PRKD30.78715945
58MAP3K90.78713596
59CAMKK10.78450490
60WNK10.77188249
61PDGFRA0.73293449
62FER0.72323791
63MAPK70.71170225
64PRKAA20.70376734
65LATS10.69540874
66NTRK30.68166821
67MAP3K60.67928307
68MAP3K50.66628429
69PRKCG0.66320599
70NEK90.66105609
71PRKCE0.63009835
72TRPM70.62578186
73KSR10.61921908
74CSNK1G20.60375151
75ADRBK10.60306614
76OXSR10.59556436
77ROCK20.59486293
78PRKACB0.59196399
79RET0.58181130
80PRPF4B0.57950116
81CAMK1D0.54516015
82NTRK10.54333418
83ADRBK20.53546576
84TGFBR20.53363143
85DAPK20.52378639
86UHMK10.52086793
87BLK0.51844283
88ERBB30.51762735
89MAP3K100.51626390
90GRK50.49585982
91PDK10.48356302
92LIMK10.47926445
93CAMK2G0.47833386
94STK390.47636282
95ACVR1B0.47623435
96CSNK1A1L0.46785684
97PRKACG0.46675599
98CAMK1G0.46504678
99ICK0.46495710
100PRKG10.46418654
101MARK20.45868860
102NTRK20.45666051
103CDK50.45544418
104PRKACA0.45360802
105KSR20.45175112
106SGK4940.40401927
107SGK2230.40401927
108SGK30.40319079
109RAF10.39734730
110SGK10.39687941
111PRKCH0.39659048
112PDPK10.38769009
113RPS6KA20.38631413
114STK40.37839298
115RPS6KA30.37160548
116LATS20.37014673
117MAP2K40.36969651
118PTK60.36587150
119SGK20.36562647
120STK110.35234638
121BCR0.34612748
122BCKDK0.34582876
123MAPK100.33989356
124PRKCZ0.32624110
125FYN0.32210615
126RPS6KC10.31888938
127RPS6KL10.31888938
128DYRK1A0.31752458
129FGFR10.30186838
130MAPK130.29638315
131CAMKK20.29274997
132PLK20.27822477

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.36045607
2* Cardiac muscle contraction_Homo sapiens_hsa042603.89798740
3* Dilated cardiomyopathy_Homo sapiens_hsa054143.80446272
4* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.58899581
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.02234188
6* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.40308130
7* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.38021529
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31559154
9Circadian entrainment_Homo sapiens_hsa047131.84396748
10* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.67827366
11Carbon metabolism_Homo sapiens_hsa012001.64833032
12Parkinsons disease_Homo sapiens_hsa050121.52576801
13Oxytocin signaling pathway_Homo sapiens_hsa049211.50327965
14Insulin secretion_Homo sapiens_hsa049111.50255149
15Fatty acid degradation_Homo sapiens_hsa000711.49240956
16Propanoate metabolism_Homo sapiens_hsa006401.47872385
17Dorso-ventral axis formation_Homo sapiens_hsa043201.47850690
18Renin secretion_Homo sapiens_hsa049241.46843387
19Type II diabetes mellitus_Homo sapiens_hsa049301.45164592
20GABAergic synapse_Homo sapiens_hsa047271.39769714
21Morphine addiction_Homo sapiens_hsa050321.38590824
22Nicotine addiction_Homo sapiens_hsa050331.38575799
23Oxidative phosphorylation_Homo sapiens_hsa001901.36285332
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35037158
25Alzheimers disease_Homo sapiens_hsa050101.30603925
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29395914
27* Calcium signaling pathway_Homo sapiens_hsa040201.23313920
28Viral myocarditis_Homo sapiens_hsa054161.21641512
29Glucagon signaling pathway_Homo sapiens_hsa049221.21140599
30Salivary secretion_Homo sapiens_hsa049701.18504247
31Fatty acid metabolism_Homo sapiens_hsa012121.17882754
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14137642
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.14027237
34Cholinergic synapse_Homo sapiens_hsa047251.10351626
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.05283377
36* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05204839
37Circadian rhythm_Homo sapiens_hsa047101.03791667
38cAMP signaling pathway_Homo sapiens_hsa040241.03586352
39Synaptic vesicle cycle_Homo sapiens_hsa047211.02902062
40Glutamatergic synapse_Homo sapiens_hsa047241.02243079
41Gastric acid secretion_Homo sapiens_hsa049711.00912744
42HIF-1 signaling pathway_Homo sapiens_hsa040660.98353222
43Long-term potentiation_Homo sapiens_hsa047200.95495619
44Insulin resistance_Homo sapiens_hsa049310.95361156
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94815454
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94149766
47* Olfactory transduction_Homo sapiens_hsa047400.93029138
48Insulin signaling pathway_Homo sapiens_hsa049100.92752819
49Biosynthesis of amino acids_Homo sapiens_hsa012300.92154607
50Dopaminergic synapse_Homo sapiens_hsa047280.89303907
51Pyruvate metabolism_Homo sapiens_hsa006200.88706090
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88700796
53Regulation of autophagy_Homo sapiens_hsa041400.88567689
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87771518
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85082650
56Huntingtons disease_Homo sapiens_hsa050160.84141857
57Fructose and mannose metabolism_Homo sapiens_hsa000510.83813135
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82873464
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82321531
60Thyroid hormone synthesis_Homo sapiens_hsa049180.78855147
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78799359
62Gap junction_Homo sapiens_hsa045400.78793089
63Focal adhesion_Homo sapiens_hsa045100.78584438
64Amphetamine addiction_Homo sapiens_hsa050310.78289698
65Taste transduction_Homo sapiens_hsa047420.76022585
66Butanoate metabolism_Homo sapiens_hsa006500.75256379
67Bile secretion_Homo sapiens_hsa049760.72121039
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.71160541
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71124833
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70826644
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67257599
72Galactose metabolism_Homo sapiens_hsa000520.65695952
73AMPK signaling pathway_Homo sapiens_hsa041520.64334357
74mTOR signaling pathway_Homo sapiens_hsa041500.64317256
75GnRH signaling pathway_Homo sapiens_hsa049120.64018559
76Tight junction_Homo sapiens_hsa045300.63431203
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62902259
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61052253
79Starch and sucrose metabolism_Homo sapiens_hsa005000.60354850
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58296998
81Serotonergic synapse_Homo sapiens_hsa047260.58167090
82Estrogen signaling pathway_Homo sapiens_hsa049150.56776983
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55171851
84Rap1 signaling pathway_Homo sapiens_hsa040150.54334409
85* Mineral absorption_Homo sapiens_hsa049780.53667790
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52409197
87Phototransduction_Homo sapiens_hsa047440.51893920
88Lysine degradation_Homo sapiens_hsa003100.51678370
89Inositol phosphate metabolism_Homo sapiens_hsa005620.49897939
90Ras signaling pathway_Homo sapiens_hsa040140.49586764
91Adherens junction_Homo sapiens_hsa045200.48837437
92Renal cell carcinoma_Homo sapiens_hsa052110.48247691
93Pancreatic secretion_Homo sapiens_hsa049720.47495366
94Long-term depression_Homo sapiens_hsa047300.45958954
95Axon guidance_Homo sapiens_hsa043600.45521610
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43404036
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43215606
98Amoebiasis_Homo sapiens_hsa051460.41876464
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.41651019
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41147224
101Endometrial cancer_Homo sapiens_hsa052130.40964664
102Platelet activation_Homo sapiens_hsa046110.40320108
103ECM-receptor interaction_Homo sapiens_hsa045120.39972291
104Hippo signaling pathway_Homo sapiens_hsa043900.39636898
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39024991
106Glioma_Homo sapiens_hsa052140.38769954
107FoxO signaling pathway_Homo sapiens_hsa040680.37971601
108ErbB signaling pathway_Homo sapiens_hsa040120.35944090
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35796432
110MAPK signaling pathway_Homo sapiens_hsa040100.35516845
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34182793
112PPAR signaling pathway_Homo sapiens_hsa033200.33996761
113Ovarian steroidogenesis_Homo sapiens_hsa049130.33648750
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33106341
115Melanogenesis_Homo sapiens_hsa049160.32839723
116TGF-beta signaling pathway_Homo sapiens_hsa043500.32752295
117Cocaine addiction_Homo sapiens_hsa050300.32001951
118Oocyte meiosis_Homo sapiens_hsa041140.31571497
119Proteoglycans in cancer_Homo sapiens_hsa052050.29816189
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.28991743
121Ether lipid metabolism_Homo sapiens_hsa005650.28892676
122Nitrogen metabolism_Homo sapiens_hsa009100.28514267
123* Protein digestion and absorption_Homo sapiens_hsa049740.28077668
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.26709178
125Choline metabolism in cancer_Homo sapiens_hsa052310.26429122
126ABC transporters_Homo sapiens_hsa020100.21625901

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