SLC7A6OS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.76099570
2negative regulation of cell killing (GO:0031342)5.76099570
3positive regulation of gamma-delta T cell activation (GO:0046645)4.72951564
4interferon-gamma production (GO:0032609)4.63196039
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.35938922
6protein localization to kinetochore (GO:0034501)4.34368039
7regulation of B cell receptor signaling pathway (GO:0050855)4.32927588
8antigen processing and presentation of endogenous antigen (GO:0019883)4.28582092
9DNA deamination (GO:0045006)4.10663917
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.06681784
11DNA strand elongation involved in DNA replication (GO:0006271)3.96197153
12folic acid-containing compound biosynthetic process (GO:0009396)3.95518513
13DNA replication initiation (GO:0006270)3.94559480
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93419325
15negative thymic T cell selection (GO:0045060)3.88967902
16DNA unwinding involved in DNA replication (GO:0006268)3.86472767
17negative T cell selection (GO:0043383)3.86110863
18mitotic nuclear envelope disassembly (GO:0007077)3.84480316
19protein localization to chromosome, centromeric region (GO:0071459)3.78658911
20DNA strand elongation (GO:0022616)3.76131682
21formation of translation preinitiation complex (GO:0001731)3.72393788
22ribosome biogenesis (GO:0042254)3.72365450
23DNA replication-dependent nucleosome assembly (GO:0006335)3.71546946
24DNA replication-dependent nucleosome organization (GO:0034723)3.71546946
25telomere maintenance via semi-conservative replication (GO:0032201)3.71311864
26mitotic metaphase plate congression (GO:0007080)3.70027913
27DNA replication checkpoint (GO:0000076)3.69578056
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.68415171
29nuclear pore organization (GO:0006999)3.68402508
30nuclear pore complex assembly (GO:0051292)3.64601912
31maturation of SSU-rRNA (GO:0030490)3.61809641
32ribosomal small subunit assembly (GO:0000028)3.60609496
33response to interleukin-15 (GO:0070672)3.55962210
34nuclear envelope disassembly (GO:0051081)3.55260526
35membrane disassembly (GO:0030397)3.55260526
36regulation of B cell differentiation (GO:0045577)3.53109060
37nucleobase biosynthetic process (GO:0046112)3.50140655
38positive regulation of granulocyte differentiation (GO:0030854)3.47333756
39cellular response to interleukin-15 (GO:0071350)3.47135703
40positive regulation of B cell differentiation (GO:0045579)3.44506317
41ribosome assembly (GO:0042255)3.40612097
42negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.38505430
43positive thymic T cell selection (GO:0045059)3.36221747
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.34888702
45mitotic sister chromatid segregation (GO:0000070)3.33996178
46response to muramyl dipeptide (GO:0032495)3.33353514
47ribonucleoprotein complex biogenesis (GO:0022613)3.33318383
48telomere maintenance via recombination (GO:0000722)3.32696969
49positive regulation by symbiont of host defense response (GO:0052509)3.28863312
50modulation by symbiont of host defense response (GO:0052031)3.28863312
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.28863312
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.28863312
53positive regulation by organism of defense response of other organism involved in symbiotic interact3.28863312
54modulation by symbiont of host immune response (GO:0052553)3.28863312
55mitotic chromosome condensation (GO:0007076)3.27597811
56viral transcription (GO:0019083)3.27491348
57purine nucleobase biosynthetic process (GO:0009113)3.24605456
58translational termination (GO:0006415)3.23843447
59response to peptidoglycan (GO:0032494)3.23762674
60positive T cell selection (GO:0043368)3.23051091
61B cell receptor signaling pathway (GO:0050853)3.22463459
62metaphase plate congression (GO:0051310)3.19845228
63regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19749835
64cellular extravasation (GO:0045123)3.19302364
65folic acid metabolic process (GO:0046655)3.19181364
66leukocyte aggregation (GO:0070486)3.19029554
67regulation of alpha-beta T cell proliferation (GO:0046640)3.16553804
68T cell selection (GO:0045058)3.15197518
69mitotic recombination (GO:0006312)3.14927473
70regulation of gamma-delta T cell activation (GO:0046643)3.13324396
71T cell migration (GO:0072678)3.12422642
72translational initiation (GO:0006413)3.11499098
73natural killer cell differentiation (GO:0001779)3.10503363
74negative regulation of phagocytosis (GO:0050765)3.09050508
75ribosomal small subunit biogenesis (GO:0042274)3.08975981
76negative regulation of innate immune response (GO:0045824)3.08891367
77regulation of interferon-beta biosynthetic process (GO:0045357)3.08758926
78regulation of spindle organization (GO:0090224)3.07686425
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07446650
80IMP biosynthetic process (GO:0006188)3.07089243
81DNA duplex unwinding (GO:0032508)3.04208903
82respiratory burst (GO:0045730)3.03899375
83positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03315785
84rRNA processing (GO:0006364)3.03050803
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01660748
86somatic hypermutation of immunoglobulin genes (GO:0016446)3.01660748
87translational elongation (GO:0006414)3.01549766
88DNA geometric change (GO:0032392)3.01398776
89sister chromatid segregation (GO:0000819)3.01267202
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.00383981
91negative regulation of RNA splicing (GO:0033119)2.99214355
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97828490
93detection of other organism (GO:0098543)2.97376693
94telomere maintenance via telomere lengthening (GO:0010833)2.97067955
95regulation of gamma-delta T cell differentiation (GO:0045586)2.96918303
96detection of bacterium (GO:0016045)2.96195001
97positive regulation of isotype switching (GO:0045830)2.95359544
98rRNA metabolic process (GO:0016072)2.95287854
99GDP-mannose metabolic process (GO:0019673)2.94602948
100positive regulation of chromosome segregation (GO:0051984)2.94212048
101negative regulation of mRNA processing (GO:0050686)2.94095803
102negative regulation of leukocyte mediated immunity (GO:0002704)2.91489061
103thymic T cell selection (GO:0045061)2.90727334
104negative regulation of T-helper cell differentiation (GO:0045623)2.90473432
105negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.90473432
106positive regulation of interferon-alpha production (GO:0032727)2.89202453
107ribosomal large subunit biogenesis (GO:0042273)2.89010478
108Arp2/3 complex-mediated actin nucleation (GO:0034314)2.87844605
109regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87194063
110nuclear envelope organization (GO:0006998)2.86416556
111rRNA modification (GO:0000154)2.86397791
112CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.85719443
113regulation of granulocyte differentiation (GO:0030852)2.84800837
114regulation of RNA export from nucleus (GO:0046831)2.83745608
115pteridine-containing compound biosynthetic process (GO:0042559)2.83243212
116regulation of translational termination (GO:0006449)2.82925336
117neutrophil activation involved in immune response (GO:0002283)2.80443404
118pseudouridine synthesis (GO:0001522)2.79490135
119termination of RNA polymerase II transcription (GO:0006369)2.79392690
120regulation of sister chromatid cohesion (GO:0007063)2.78509609
121positive regulation of interferon-beta production (GO:0032728)2.78449415
122nucleotide-excision repair, DNA gap filling (GO:0006297)2.77958170
123RNA splicing, via transesterification reactions (GO:0000375)2.77527259
124regulation of telomere maintenance via telomerase (GO:0032210)2.77350097
125RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.75920244
126mRNA splicing, via spliceosome (GO:0000398)2.75920244
127spliceosomal snRNP assembly (GO:0000387)2.75430250
128pore complex assembly (GO:0046931)2.74993652
129IMP metabolic process (GO:0046040)2.73330585
130pre-miRNA processing (GO:0031054)2.72814932
131kinetochore organization (GO:0051383)2.72374691
132positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.71670513
133chromatin remodeling at centromere (GO:0031055)2.71318900
134DNA replication-independent nucleosome assembly (GO:0006336)2.70804973
135DNA replication-independent nucleosome organization (GO:0034724)2.70804973
136chromatin assembly or disassembly (GO:0006333)2.70575215
137tolerance induction (GO:0002507)2.70457173
138establishment of chromosome localization (GO:0051303)2.70125236
139protein localization to chromosome (GO:0034502)2.69412460
140CENP-A containing nucleosome assembly (GO:0034080)2.68983170
141megakaryocyte development (GO:0035855)2.67590895
142regulation of interferon-beta production (GO:0032648)2.67224737
143regulation of gene silencing by RNA (GO:0060966)2.67179024
144regulation of posttranscriptional gene silencing (GO:0060147)2.67179024
145regulation of gene silencing by miRNA (GO:0060964)2.67179024
146regulation of translation in response to stress (GO:0043555)2.66513725
147heterochromatin organization (GO:0070828)2.65559258
148mitotic G1 DNA damage checkpoint (GO:0031571)2.65375770
149G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.65243372
150NIK/NF-kappaB signaling (GO:0038061)2.64695717
151negative regulation of interleukin-12 production (GO:0032695)2.64538380
152metallo-sulfur cluster assembly (GO:0031163)2.63292174
153iron-sulfur cluster assembly (GO:0016226)2.63292174
154dosage compensation (GO:0007549)2.62946763
155regulation of interferon-alpha production (GO:0032647)2.62892544
156maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61746633
157macrophage activation involved in immune response (GO:0002281)2.61683548
158regulation of translational fidelity (GO:0006450)2.60580839
1593-UTR-mediated mRNA stabilization (GO:0070935)2.60213306
160histone H2A monoubiquitination (GO:0035518)2.60088096
161immunoglobulin mediated immune response (GO:0016064)2.59746547
162SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.59643798
163positive regulation of DNA recombination (GO:0045911)2.59050512
164negative regulation of mRNA metabolic process (GO:1903312)2.58627395
165nuclear-transcribed mRNA catabolic process (GO:0000956)2.58622711
166regulation of natural killer cell mediated immunity (GO:0002715)2.57424210
167regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.57424210
168attachment of spindle microtubules to kinetochore (GO:0008608)2.56718253
169RNA export from nucleus (GO:0006405)2.55747478
170T cell homeostasis (GO:0043029)2.55651472
171negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.55441837
172mitochondrial DNA metabolic process (GO:0032042)2.55075143
173negative regulation of T cell mediated immunity (GO:0002710)2.54866203
174regulation of mitotic spindle organization (GO:0060236)2.54802414
175rRNA transcription (GO:0009303)2.54027045
176maturation of 5.8S rRNA (GO:0000460)2.53792618
177B cell mediated immunity (GO:0019724)2.52485773
178cellular response to virus (GO:0098586)2.52130640
179purinergic nucleotide receptor signaling pathway (GO:0035590)2.48744323
180myeloid cell activation involved in immune response (GO:0002275)2.46993289
181base-excision repair, AP site formation (GO:0006285)2.44165068
182negative regulation of type I interferon production (GO:0032480)2.43839908
183antigen receptor-mediated signaling pathway (GO:0050851)2.43825033
184negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.40856185
185mast cell activation (GO:0045576)2.40762043
186defense response to protozoan (GO:0042832)2.40569597
187myeloid dendritic cell activation (GO:0001773)2.36332048
188positive regulation of interleukin-2 production (GO:0032743)2.35935730
189activated T cell proliferation (GO:0050798)2.35771636
190granulocyte differentiation (GO:0030851)2.34459303
191neutrophil activation (GO:0042119)2.34254490
192regulation of T-helper 1 cell differentiation (GO:0045625)2.33098597
193regulation of isotype switching to IgG isotypes (GO:0048302)2.32766006
194regulation of mast cell degranulation (GO:0043304)2.32749230
195pyrimidine nucleotide catabolic process (GO:0006244)2.29773843
196T cell proliferation (GO:0042098)2.26048959
197positive regulation of B cell activation (GO:0050871)2.25940008
198regulation of isotype switching (GO:0045191)2.25653200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.01761745
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.75077830
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.73661004
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32225166
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03850756
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87252948
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68634026
8MYC_22102868_ChIP-Seq_BL_Human2.50215556
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49337220
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47104302
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.42174668
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.25369866
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.20731910
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.17982668
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17440650
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12225558
17* XRN2_22483619_ChIP-Seq_HELA_Human2.07920105
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.05145016
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04169952
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.03240884
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02136276
22* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01162237
23VDR_24763502_ChIP-Seq_THP-1_Human1.94231454
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91963450
25* VDR_23849224_ChIP-Seq_CD4+_Human1.89741278
26MYB_26560356_Chip-Seq_TH2_Human1.81175747
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79679556
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76344710
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75034914
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74180764
31* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71564374
32AR_21909140_ChIP-Seq_LNCAP_Human1.70464412
33DCP1A_22483619_ChIP-Seq_HELA_Human1.70333784
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69909483
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69486835
36FOXP3_21729870_ChIP-Seq_TREG_Human1.66987348
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66134867
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65995859
39GABP_19822575_ChIP-Seq_HepG2_Human1.65142001
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64956367
41* E2F1_21310950_ChIP-Seq_MCF-7_Human1.62563597
42CIITA_25753668_ChIP-Seq_RAJI_Human1.62216528
43VDR_21846776_ChIP-Seq_THP-1_Human1.61572645
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60223063
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59187109
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59181950
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57248699
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56823631
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55256210
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54858848
51KDM5A_27292631_Chip-Seq_BREAST_Human1.54198121
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53865847
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53483999
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.47461651
55TTF2_22483619_ChIP-Seq_HELA_Human1.46641699
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46073064
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43963758
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.42146786
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41739614
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41179581
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41063014
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40819754
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38112669
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37830226
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.36208445
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36054743
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35658349
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34056283
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33491814
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32208111
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32058326
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31851706
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31725459
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30695323
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26403855
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26227642
77RUNX_20019798_ChIP-Seq_JUKART_Human1.25076823
78BCL6_27268052_Chip-Seq_Bcells_Human1.23821319
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23138417
80SCL_19346495_ChIP-Seq_HPC-7_Human1.23114964
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.22441767
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20202292
83KDM2B_26808549_Chip-Seq_DND41_Human1.19905782
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18799237
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18073665
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.17855162
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16904876
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16749022
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15562563
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15062964
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14594671
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14017539
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13190750
94GATA3_27048872_Chip-Seq_THYMUS_Human1.13012113
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12998377
96TFEB_21752829_ChIP-Seq_HELA_Human1.11213999
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10453967
98NCOR1_26117541_ChIP-Seq_K562_Human1.10360588
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10056925
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09330603
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08739400
102ELK1_19687146_ChIP-ChIP_HELA_Human1.08727496
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06810729
104UTX_26944678_Chip-Seq_JUKART_Human1.06081887
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05688199
106TCF7_22412390_ChIP-Seq_EML_Mouse1.05294430
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05246644
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05246644
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05246644
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04081353
111MAF_26560356_Chip-Seq_TH1_Human1.03311309
112* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03019573
113* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02957927
114SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01861993
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00881326
116NANOG_21062744_ChIP-ChIP_HESCs_Human0.98504601
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97881979
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97850188
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96291017
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95666986
121MYB_26560356_Chip-Seq_TH1_Human0.95318629
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95113823
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95071447
124MAF_26560356_Chip-Seq_TH2_Human0.94539884
125* SPI1_23547873_ChIP-Seq_NB4_Human0.94058285
126ZNF263_19887448_ChIP-Seq_K562_Human0.92459887
127PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91031760
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90662386
129SRF_21415370_ChIP-Seq_HL-1_Mouse0.90225938
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.89719043
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89002072

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.34492213
2MP0004957_abnormal_blastocyst_morpholog3.66153839
3MP0010094_abnormal_chromosome_stability3.64445694
4MP0008057_abnormal_DNA_replication3.60517477
5MP0003111_abnormal_nucleus_morphology3.46113391
6MP0003077_abnormal_cell_cycle3.26298582
7MP0003303_peritoneal_inflammation3.09768574
8MP0001835_abnormal_antigen_presentation2.72387096
9MP0010352_gastrointestinal_tract_polyps2.61859524
10MP0003724_increased_susceptibility_to2.44720067
11MP0008058_abnormal_DNA_repair2.43885441
12MP0008007_abnormal_cellular_replicative2.37326121
13MP0002396_abnormal_hematopoietic_system2.36741061
14MP0005000_abnormal_immune_tolerance2.32638203
15MP0005025_abnormal_response_to2.25685945
16MP0005423_abnormal_somatic_nervous2.19785119
17MP0000350_abnormal_cell_proliferation2.14482259
18MP0001730_embryonic_growth_arrest2.09561574
19MP0005387_immune_system_phenotype2.02562676
20MP0001790_abnormal_immune_system2.02562676
21MP0001986_abnormal_taste_sensitivity1.97472157
22MP0002419_abnormal_innate_immunity1.95180608
23MP0008932_abnormal_embryonic_tissue1.91561387
24MP0003763_abnormal_thymus_physiology1.90609932
25MP0004381_abnormal_hair_follicle1.89424518
26MP0000490_abnormal_crypts_of1.83718621
27MP0003806_abnormal_nucleotide_metabolis1.79641719
28MP0005380_embryogenesis_phenotype1.73976350
29MP0001672_abnormal_embryogenesis/_devel1.73976350
30MP0005076_abnormal_cell_differentiation1.71505594
31MP0010307_abnormal_tumor_latency1.67802691
32MP0009785_altered_susceptibility_to1.67655888
33MP0000015_abnormal_ear_pigmentation1.63762501
34MP0001697_abnormal_embryo_size1.63234017
35MP0005084_abnormal_gallbladder_morpholo1.62807140
36MP0009333_abnormal_splenocyte_physiolog1.62252927
37MP0003984_embryonic_growth_retardation1.60267664
38MP0002088_abnormal_embryonic_growth/wei1.58946293
39MP0006082_CNS_inflammation1.58813575
40MP0004264_abnormal_extraembryonic_tissu1.58238157
41MP0003705_abnormal_hypodermis_morpholog1.56650197
42MP0008260_abnormal_autophagy1.53849246
43MP0005464_abnormal_platelet_physiology1.53117371
44MP0005083_abnormal_biliary_tract1.51511526
45MP0002086_abnormal_extraembryonic_tissu1.50143761
46MP0002148_abnormal_hypersensitivity_rea1.49525447
47MP0003172_abnormal_lysosome_physiology1.48224177
48MP0003136_yellow_coat_color1.47060578
49MP0002019_abnormal_tumor_incidence1.46597238
50MP0002080_prenatal_lethality1.45972705
51MP0002085_abnormal_embryonic_tissue1.45821510
52MP0009840_abnormal_foam_cell1.44936265
53MP0004197_abnormal_fetal_growth/weight/1.44403435
54MP0002084_abnormal_developmental_patter1.43050961
55MP0003786_premature_aging1.42831987
56MP0004808_abnormal_hematopoietic_stem1.40717900
57MP0002398_abnormal_bone_marrow1.37663930
58MP0001545_abnormal_hematopoietic_system1.36148257
59MP0005397_hematopoietic_system_phenotyp1.36148257
60MP0000703_abnormal_thymus_morphology1.33814810
61MP0000689_abnormal_spleen_morphology1.30517961
62MP0002722_abnormal_immune_system1.28000572
63MP0000313_abnormal_cell_death1.25985598
64MP0005174_abnormal_tail_pigmentation1.25698769
65MP0001845_abnormal_inflammatory_respons1.22856299
66MP0010030_abnormal_orbit_morphology1.22595231
67MP0003123_paternal_imprinting1.19884632
68MP0005023_abnormal_wound_healing1.19358328
69MP0003828_pulmonary_edema1.17612354
70MP0003718_maternal_effect1.17349217
71MP0003890_abnormal_embryonic-extraembry1.14512702
72MP0001849_ear_inflammation1.13874812
73MP0000751_myopathy1.13516083
74MP0008469_abnormal_protein_level1.12443407
75MP0003567_abnormal_fetal_cardiomyocyte1.12414265
76MP0000685_abnormal_immune_system1.09119777
77MP0006035_abnormal_mitochondrial_morpho1.07454302
78MP0001188_hyperpigmentation1.07111913
79MP0002429_abnormal_blood_cell1.04086818
80MP0009053_abnormal_anal_canal1.01725969
81MP0005171_absent_coat_pigmentation1.01347428
82MP0001800_abnormal_humoral_immune1.01275119
83MP0008877_abnormal_DNA_methylation0.98132739
84MP0001853_heart_inflammation0.97426385
85MP0002132_abnormal_respiratory_system0.96506642
86MP0000716_abnormal_immune_system0.95853077
87MP0003566_abnormal_cell_adhesion0.95786572
88MP0005451_abnormal_body_composition0.95597512
89MP0005075_abnormal_melanosome_morpholog0.95074525
90MP0000858_altered_metastatic_potential0.94139243
91MP0001293_anophthalmia0.93299096
92MP0002653_abnormal_ependyma_morphology0.92275856
93MP0003866_abnormal_defecation0.92157761
94MP0000477_abnormal_intestine_morphology0.91941888
95MP0002405_respiratory_system_inflammati0.91345050
96MP0000465_gastrointestinal_hemorrhage0.91231321
97MP0009278_abnormal_bone_marrow0.90613646
98MP0005501_abnormal_skin_physiology0.89164809
99MP0005310_abnormal_salivary_gland0.87544180
100MP0002166_altered_tumor_susceptibility0.85763302
101MP0005671_abnormal_response_to0.84018346
102MP0003453_abnormal_keratinocyte_physiol0.83959526
103MP0006054_spinal_hemorrhage0.83123967
104MP0002111_abnormal_tail_morphology0.82520512
105MP0001533_abnormal_skeleton_physiology0.82395817
106MP0001727_abnormal_embryo_implantation0.81406250
107MP0009672_abnormal_birth_weight0.80681762
108MP0003119_abnormal_digestive_system0.80466958
109MP0002210_abnormal_sex_determination0.80268945
110MP0000598_abnormal_liver_morphology0.79345540
111MP0010155_abnormal_intestine_physiology0.79106009
112MP0008995_early_reproductive_senescence0.78886433
113MP0000358_abnormal_cell_content/0.78861572
114MP0002420_abnormal_adaptive_immunity0.77547055
115MP0001145_abnormal_male_reproductive0.77017923
116MP0005621_abnormal_cell_physiology0.76789325
117MP0006292_abnormal_olfactory_placode0.76531666
118MP0000750_abnormal_muscle_regeneration0.76004989
119MP0001919_abnormal_reproductive_system0.75567531
120MP0003436_decreased_susceptibility_to0.75534349
121MP0004185_abnormal_adipocyte_glucose0.75460673
122MP0002877_abnormal_melanocyte_morpholog0.75018165
123MP0001819_abnormal_immune_cell0.74176264
124MP0003656_abnormal_erythrocyte_physiolo0.73778263
125MP0001119_abnormal_female_reproductive0.73079449
126MP0005384_cellular_phenotype0.73064314
127MP0000609_abnormal_liver_physiology0.73044477
128MP0002092_abnormal_eye_morphology0.72787621
129MP0002452_abnormal_antigen_presenting0.72506954
130MP0001243_abnormal_dermal_layer0.72314356
131MP0005584_abnormal_enzyme/coenzyme_acti0.71971253
132MP0004130_abnormal_muscle_cell0.71823910
133MP0003448_altered_tumor_morphology0.70319284
134MP0001929_abnormal_gametogenesis0.69808003
135MP0002723_abnormal_immune_serum0.69783063
136MP0001915_intracranial_hemorrhage0.69102904
137MP0008770_decreased_survivor_rate0.69089327
138MP0005058_abnormal_lysosome_morphology0.68597144
139MP0000653_abnormal_sex_gland0.67083399
140MP0010234_abnormal_vibrissa_follicle0.66495950
141MP0002932_abnormal_joint_morphology0.65038858
142MP0001663_abnormal_digestive_system0.63833554
143MP0003221_abnormal_cardiomyocyte_apopto0.63516463
144MP0004947_skin_inflammation0.63361283
145MP0001873_stomach_inflammation0.63139800
146MP0008004_abnormal_stomach_pH0.62759409

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.22624750
2Stomatitis (HP:0010280)4.16768792
3Hypochromic anemia (HP:0001931)4.02570861
4Panhypogammaglobulinemia (HP:0003139)3.97864230
5Recurrent abscess formation (HP:0002722)3.90676410
6Recurrent bacterial skin infections (HP:0005406)3.90046744
7Birth length less than 3rd percentile (HP:0003561)3.88598847
8Eczematoid dermatitis (HP:0000976)3.63954309
9Myositis (HP:0100614)3.60045754
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.42229428
11Recurrent fungal infections (HP:0002841)3.20829918
12Abnormality of cells of the erythroid lineage (HP:0012130)3.18834137
13Ependymoma (HP:0002888)3.16828627
14Breast hypoplasia (HP:0003187)3.16035907
15Encephalitis (HP:0002383)3.13091341
16Retrobulbar optic neuritis (HP:0100654)3.11726832
17Optic neuritis (HP:0100653)3.11726832
18Abnormal number of erythroid precursors (HP:0012131)3.10635689
19Vaginal fistula (HP:0004320)3.09770777
20Recurrent cutaneous fungal infections (HP:0011370)3.09397635
21Chronic mucocutaneous candidiasis (HP:0002728)3.09397635
22Orchitis (HP:0100796)3.09378928
23Aplastic anemia (HP:0001915)3.09281342
24Gastrointestinal infarctions (HP:0005244)3.07205030
25Meningitis (HP:0001287)3.04753948
26Carpal bone hypoplasia (HP:0001498)3.02999034
27Selective tooth agenesis (HP:0001592)3.01119090
28Multiple enchondromatosis (HP:0005701)2.98011858
29Patellar aplasia (HP:0006443)2.90726443
30Oral leukoplakia (HP:0002745)2.89424192
31Abnormality of macrophages (HP:0004311)2.88219198
32Rhabdomyosarcoma (HP:0002859)2.80359367
33Reticulocytopenia (HP:0001896)2.80323970
34T lymphocytopenia (HP:0005403)2.79774477
35Mediastinal lymphadenopathy (HP:0100721)2.74294558
36Microcytic anemia (HP:0001935)2.71011484
37Basal cell carcinoma (HP:0002671)2.70514187
38Reduced antithrombin III activity (HP:0001976)2.69947011
39Aplasia/Hypoplasia of the patella (HP:0006498)2.67965983
40Recurrent skin infections (HP:0001581)2.66794199
41Microvesicular hepatic steatosis (HP:0001414)2.66022534
42Colitis (HP:0002583)2.65574615
43Rib fusion (HP:0000902)2.64497116
44Fatigue (HP:0012378)2.63202342
45Abnormality of T cell number (HP:0011839)2.61789627
46Premature ovarian failure (HP:0008209)2.58683707
47Recurrent viral infections (HP:0004429)2.57511819
48Chronic obstructive pulmonary disease (HP:0006510)2.56946404
49Obstructive lung disease (HP:0006536)2.56946404
50Microretrognathia (HP:0000308)2.56352743
51Agammaglobulinemia (HP:0004432)2.54740146
52Medulloblastoma (HP:0002885)2.54267347
53Degeneration of anterior horn cells (HP:0002398)2.50554819
54Abnormality of the anterior horn cell (HP:0006802)2.50554819
55Severe combined immunodeficiency (HP:0004430)2.49935731
56Chest pain (HP:0100749)2.45365913
57Colon cancer (HP:0003003)2.39503262
58Rough bone trabeculation (HP:0100670)2.37744584
59IgG deficiency (HP:0004315)2.36361896
60Anorexia (HP:0002039)2.35810789
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33683729
62Abnormality of the labia minora (HP:0012880)2.32024966
63Poikiloderma (HP:0001029)2.31627604
64Increased IgM level (HP:0003496)2.30631744
65Keratoconjunctivitis sicca (HP:0001097)2.30245942
66Lymphopenia (HP:0001888)2.29555406
67Elevated erythrocyte sedimentation rate (HP:0003565)2.26508989
68Squamous cell carcinoma (HP:0002860)2.26209346
69Prominent nose (HP:0000448)2.24425498
70Abnormality of DNA repair (HP:0003254)2.23735643
71Facial hemangioma (HP:0000329)2.22579662
72Keratoconjunctivitis (HP:0001096)2.22298073
73Trismus (HP:0000211)2.21309486
74Neoplasm of striated muscle (HP:0009728)2.20620527
75Facial diplegia (HP:0001349)2.20228575
76Granulocytopenia (HP:0001913)2.19151232
77Papilledema (HP:0001085)2.18816344
78IgM deficiency (HP:0002850)2.18255313
79Myelodysplasia (HP:0002863)2.18090173
80Abnormality of the ileum (HP:0001549)2.17914957
81Secondary amenorrhea (HP:0000869)2.17432654
82Thrombocytosis (HP:0001894)2.16046308
83Gastrointestinal inflammation (HP:0004386)2.15567519
84Impulsivity (HP:0100710)2.14511009
85Meckel diverticulum (HP:0002245)2.14274086
86Neoplasm of the pancreas (HP:0002894)2.12956491
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.12551696
88Vasculitis (HP:0002633)2.12486995
89Petechiae (HP:0000967)2.12468546
90Progressive muscle weakness (HP:0003323)2.11714645
91Abnormality of the astrocytes (HP:0100707)2.11703277
92Astrocytoma (HP:0009592)2.11703277
93Sparse lateral eyebrow (HP:0005338)2.09546287
94Combined immunodeficiency (HP:0005387)2.07567430
95Inflammation of the large intestine (HP:0002037)2.07259050
96Macrocytic anemia (HP:0001972)2.07122450
97Recurrent gram-negative bacterial infections (HP:0005420)2.05882495
98Abnormality of the fingertips (HP:0001211)2.05002089
99Chromsome breakage (HP:0040012)2.04228182
100Arterial thrombosis (HP:0004420)2.03701797
101Exertional dyspnea (HP:0002875)2.03437772
102Increased IgE level (HP:0003212)2.03316471
103Atresia of the external auditory canal (HP:0000413)2.03246201
104Entropion (HP:0000621)2.03210687
105Pallor (HP:0000980)2.02003447
106Absent thumb (HP:0009777)2.01620815
107Abnormality of chromosome stability (HP:0003220)2.00735082
108Lymphoma (HP:0002665)2.00561165
109Cellulitis (HP:0100658)2.00497392
110Anteriorly placed anus (HP:0001545)1.99639183
111Urticaria (HP:0001025)1.99181299
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.94810346
113Papilloma (HP:0012740)1.94657053
114Verrucae (HP:0200043)1.94657053
115Increased density of long bones (HP:0006392)1.92565903
116Absent radius (HP:0003974)1.91415307
117Deviation of the thumb (HP:0009603)1.90941234
118Premature graying of hair (HP:0002216)1.89706651
119Preauricular skin tag (HP:0000384)1.88480857
120Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88194763
121Spontaneous hematomas (HP:0007420)1.86580464
122Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86410953
123Neutropenia (HP:0001875)1.85073202
124Proximal placement of thumb (HP:0009623)1.84385474
125Acute hepatic failure (HP:0006554)1.84206098
126Pseudobulbar signs (HP:0002200)1.83559617
127Overlapping toe (HP:0001845)1.83010264
128Abnormality of the preputium (HP:0100587)1.82994040
129Cerebral hypomyelination (HP:0006808)1.82065138
130Abnormality of B cell number (HP:0010975)1.81722525
131B lymphocytopenia (HP:0010976)1.81722525
132Testicular atrophy (HP:0000029)1.80974219
133Hypoplasia of the thymus (HP:0000778)1.80593178
134Agnosia (HP:0010524)1.80571763
135Missing ribs (HP:0000921)1.79248105
136Skin tags (HP:0010609)1.78675215
137Atrophy/Degeneration involving motor neurons (HP:0007373)1.78509479
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.78330265
139Viral hepatitis (HP:0006562)1.77376592
140Short 5th finger (HP:0009237)1.74588373
141Epistaxis (HP:0000421)1.74381031
142Abnormality of eosinophils (HP:0001879)1.72946299
143Absent forearm bone (HP:0003953)1.72688963
144Aplasia involving forearm bones (HP:0009822)1.72688963
145Sloping forehead (HP:0000340)1.72534913
146Increased muscle lipid content (HP:0009058)1.72431686
1473-Methylglutaconic aciduria (HP:0003535)1.71733067
148Leukocytosis (HP:0001974)1.71719617
149Bone marrow hypocellularity (HP:0005528)1.71155796
150Hyperinsulinemic hypoglycemia (HP:0000825)1.70902136
151Increased intramyocellular lipid droplets (HP:0012240)1.70561258
152Aplasia/hypoplasia of the humerus (HP:0006507)1.70508071
153Pancytopenia (HP:0001876)1.70153476
154Cellular immunodeficiency (HP:0005374)1.69993765
155Glioma (HP:0009733)1.69685508
156Prolonged bleeding time (HP:0003010)1.69635933
157Optic nerve coloboma (HP:0000588)1.69492727
158Abnormality of T cells (HP:0002843)1.66788957
159Abnormality of pyrimidine metabolism (HP:0004353)1.65947045
160Duodenal stenosis (HP:0100867)1.65670397
161Small intestinal stenosis (HP:0012848)1.65670397
162Muscle fiber atrophy (HP:0100295)1.65542400
163Intestinal fistula (HP:0100819)1.65502957
164Leukopenia (HP:0001882)1.64889605
165Amaurosis fugax (HP:0100576)1.63920362
166Cafe-au-lait spot (HP:0000957)1.63597521
167Slender long bone (HP:0003100)1.62548211
168Increased nuchal translucency (HP:0010880)1.62257158
169Abnormality of T cell physiology (HP:0011840)1.61250175
170Rectovaginal fistula (HP:0000143)1.60149068
171Rectal fistula (HP:0100590)1.60149068
172Tracheoesophageal fistula (HP:0002575)1.60138471
173Spastic diplegia (HP:0001264)1.59622966
174Abnormality of the lower motor neuron (HP:0002366)1.59089675
175Hypobetalipoproteinemia (HP:0003563)1.57471957
176Abnormal number of incisors (HP:0011064)1.57339453
177Glossoptosis (HP:0000162)1.56623449
178Pustule (HP:0200039)1.56087436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.28708311
2WEE13.26883254
3RIPK43.09324421
4CDC72.86492314
5BUB12.86212096
6BLK2.55386662
7NEK22.48821181
8ACVR1B2.38549554
9SIK32.37649189
10CDK192.33541353
11EEF2K2.25208419
12PRPF4B2.15964231
13STK102.12393462
14SRPK12.04414245
15MAP4K12.03933724
16DYRK31.99744782
17VRK21.97778161
18IRAK41.96670720
19RPS6KB21.94085874
20MAP3K101.93793948
21CDK71.93193775
22NME21.92531678
23TESK21.91870329
24RPS6KA41.91152308
25IKBKE1.81665818
26MAP3K111.79672270
27FES1.79613464
28TTK1.78317269
29SIK21.76255598
30EPHA21.65811013
31CDK41.64376716
32EIF2AK11.62356215
33TLK11.57592388
34PLK11.56784297
35PDK21.55155611
36BRSK21.50838160
37CDK91.50687051
38TRIB31.48873837
39TSSK61.48012492
40SMG11.47631572
41PIM11.41812778
42NUAK11.39457123
43NEK11.38996126
44LYN1.38703873
45PKN21.38598212
46AURKB1.36285573
47CHEK21.35764773
48GRK61.35257904
49MAP3K81.32627290
50LCK1.32035868
51TNIK1.31953379
52SYK1.30619012
53ATR1.27756137
54ERN11.27110625
55HCK1.26857863
56MAPKAPK31.25460685
57PIK3CG1.18900321
58MAP3K141.18275792
59EIF2AK31.16577190
60VRK11.15217663
61MAP3K61.13170388
62SCYL21.11849797
63PLK41.06175705
64CHEK11.05954914
65MUSK1.05058455
66TEC1.04780789
67PAK41.04707773
68MAPK151.03796142
69BRSK11.00781912
70IRAK21.00327449
71AURKA0.98689447
72TGFBR10.97740777
73CDK60.97187685
74RAF10.96854076
75KDR0.95680297
76PIM20.93867689
77STK30.93265747
78MARK30.92497882
79TNK20.90934699
80LRRK20.89669219
81FLT30.89391397
82ALK0.87331001
83TYRO30.86606859
84LATS20.85381549
85ZAP700.85260451
86KIT0.84216494
87MAPK110.80468699
88CDK20.79471917
89STK40.78846516
90LATS10.77266817
91CSF1R0.76138559
92MAP2K20.75120707
93CDK80.74761172
94MAP2K30.74641042
95MTOR0.74329667
96JAK30.74186177
97TAOK10.72970064
98NLK0.71315851
99TAF10.71045985
100BRD40.69438896
101PASK0.68999403
102TXK0.68068509
103MKNK10.67942438
104YES10.66579231
105ATM0.66486396
106EPHB10.65869482
107MAP4K20.64910354
108PBK0.61937770
109ICK0.61091466
110MELK0.60557018
111SIK10.59360965
112CDK30.58358760
113TGFBR20.57547322
114KSR20.56950405
115TRIM280.56049727
116STK160.54874452
117DYRK1B0.54802691
118JAK10.52716205
119CHUK0.52670913
120IKBKB0.51514706
121PLK30.51333041
122MAPK120.51137473
123TYK20.50475607
124MATK0.50122715
125PRKCQ0.49014435
126FGFR40.48984789
127CSK0.48282672
128CSNK2A20.48061310
129PRKCI0.46288630
130JAK20.45865011
131CDK10.45632794
132TBK10.44567268
133DYRK20.43986670
134TAOK30.43833249
135BRAF0.43745357
136BTK0.43347385
137ITK0.43300775
138FGR0.42251723
139AKT20.41952099
140MAP3K30.41465922
141BCKDK0.39925999
142MKNK20.39883442
143DDR20.39631843
144CSNK2A10.38974766
145STK110.38104322
146PDK10.36401271
147RPS6KB10.32390074
148FYN0.30925796
149MAPKAPK20.30552615
150RPS6KL10.28250775
151RPS6KC10.28250775

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.27882447
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52717367
3Mismatch repair_Homo sapiens_hsa034303.47985435
4Spliceosome_Homo sapiens_hsa030403.12409760
5RNA transport_Homo sapiens_hsa030132.91181300
6Base excision repair_Homo sapiens_hsa034102.81490655
7Ribosome_Homo sapiens_hsa030102.81365948
8One carbon pool by folate_Homo sapiens_hsa006702.60818422
9Cell cycle_Homo sapiens_hsa041102.48133826
10RNA polymerase_Homo sapiens_hsa030202.42046041
11Nucleotide excision repair_Homo sapiens_hsa034202.30811939
12Allograft rejection_Homo sapiens_hsa053302.12947435
13Homologous recombination_Homo sapiens_hsa034402.06092155
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04008874
15Autoimmune thyroid disease_Homo sapiens_hsa053201.98508415
16Pyrimidine metabolism_Homo sapiens_hsa002401.96072995
17Leishmaniasis_Homo sapiens_hsa051401.87642968
18Proteasome_Homo sapiens_hsa030501.85951482
19Graft-versus-host disease_Homo sapiens_hsa053321.80294422
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76783891
21RNA degradation_Homo sapiens_hsa030181.74172587
22p53 signaling pathway_Homo sapiens_hsa041151.73483345
23mRNA surveillance pathway_Homo sapiens_hsa030151.71591608
24Osteoclast differentiation_Homo sapiens_hsa043801.65621747
25Non-homologous end-joining_Homo sapiens_hsa034501.59953448
26Fanconi anemia pathway_Homo sapiens_hsa034601.56457417
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55440557
28Sulfur relay system_Homo sapiens_hsa041221.53337107
29Basal transcription factors_Homo sapiens_hsa030221.50572798
30Viral myocarditis_Homo sapiens_hsa054161.49542389
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43537167
32Folate biosynthesis_Homo sapiens_hsa007901.37419905
33Vitamin B6 metabolism_Homo sapiens_hsa007501.31136376
34Selenocompound metabolism_Homo sapiens_hsa004501.29082473
35Primary immunodeficiency_Homo sapiens_hsa053401.28617391
36Tuberculosis_Homo sapiens_hsa051521.27685266
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27664681
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24257489
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23514133
40Biosynthesis of amino acids_Homo sapiens_hsa012301.21134828
41Herpes simplex infection_Homo sapiens_hsa051681.16293651
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.13729291
43Epstein-Barr virus infection_Homo sapiens_hsa051691.10897618
44Pentose phosphate pathway_Homo sapiens_hsa000301.08079742
45Asthma_Homo sapiens_hsa053101.07583972
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.06231138
47Systemic lupus erythematosus_Homo sapiens_hsa053221.05288722
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04220231
49Antigen processing and presentation_Homo sapiens_hsa046121.02223876
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.01148815
51Other glycan degradation_Homo sapiens_hsa005110.98700286
52Viral carcinogenesis_Homo sapiens_hsa052030.98392524
53Chemokine signaling pathway_Homo sapiens_hsa040620.96650371
54Thyroid cancer_Homo sapiens_hsa052160.96300881
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94564894
56HTLV-I infection_Homo sapiens_hsa051660.91525250
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90185428
58Type I diabetes mellitus_Homo sapiens_hsa049400.89259999
59Toxoplasmosis_Homo sapiens_hsa051450.84228730
60Small cell lung cancer_Homo sapiens_hsa052220.83807839
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81087721
62Staphylococcus aureus infection_Homo sapiens_hsa051500.80365132
63Inositol phosphate metabolism_Homo sapiens_hsa005620.78973532
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77530241
65MicroRNAs in cancer_Homo sapiens_hsa052060.74880501
66Bladder cancer_Homo sapiens_hsa052190.72513346
67Endometrial cancer_Homo sapiens_hsa052130.72375768
68Purine metabolism_Homo sapiens_hsa002300.72105700
69Acute myeloid leukemia_Homo sapiens_hsa052210.70857682
70Hepatitis C_Homo sapiens_hsa051600.70852525
71Apoptosis_Homo sapiens_hsa042100.69899738
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.69513059
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.66096539
74Chronic myeloid leukemia_Homo sapiens_hsa052200.65899736
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.65014396
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64627868
77Malaria_Homo sapiens_hsa051440.63070732
78mTOR signaling pathway_Homo sapiens_hsa041500.63057064
79Colorectal cancer_Homo sapiens_hsa052100.62311532
80Legionellosis_Homo sapiens_hsa051340.60310057
81TNF signaling pathway_Homo sapiens_hsa046680.60002320
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.59533194
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59301694
84Fructose and mannose metabolism_Homo sapiens_hsa000510.59264221
85Notch signaling pathway_Homo sapiens_hsa043300.57616171
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56756549
87Hepatitis B_Homo sapiens_hsa051610.56494882
88Carbon metabolism_Homo sapiens_hsa012000.56359235
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55250940
90Regulation of autophagy_Homo sapiens_hsa041400.53725674
91Measles_Homo sapiens_hsa051620.53679759
92Shigellosis_Homo sapiens_hsa051310.53592649
93Lysine degradation_Homo sapiens_hsa003100.53009964
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52697204
95Glutathione metabolism_Homo sapiens_hsa004800.52185712
96Oocyte meiosis_Homo sapiens_hsa041140.51732678
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51407076
98Endocytosis_Homo sapiens_hsa041440.51349032
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50461486
100Basal cell carcinoma_Homo sapiens_hsa052170.50217873
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49535501
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.49072819
103Caffeine metabolism_Homo sapiens_hsa002320.49045763
104Prostate cancer_Homo sapiens_hsa052150.49025777
105B cell receptor signaling pathway_Homo sapiens_hsa046620.47500245
106T cell receptor signaling pathway_Homo sapiens_hsa046600.47290184
107Hippo signaling pathway_Homo sapiens_hsa043900.47022418
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45675943
109FoxO signaling pathway_Homo sapiens_hsa040680.44684888
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44321568
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43430439
112Platelet activation_Homo sapiens_hsa046110.43165460
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.42059483
114Pancreatic cancer_Homo sapiens_hsa052120.41209518
115Salmonella infection_Homo sapiens_hsa051320.41139938
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41008455
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40835616
118Galactose metabolism_Homo sapiens_hsa000520.40493168
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39415618
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39408199
121Prolactin signaling pathway_Homo sapiens_hsa049170.39288468
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38261303
123Phagosome_Homo sapiens_hsa041450.37715328
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33998609
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33901815
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33620499
127TGF-beta signaling pathway_Homo sapiens_hsa043500.33232353
128Arginine biosynthesis_Homo sapiens_hsa002200.33198483
129N-Glycan biosynthesis_Homo sapiens_hsa005100.32208941
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31863572
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31192553
132Non-small cell lung cancer_Homo sapiens_hsa052230.30994889
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.30755878
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.30699810
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28300728
136Arginine and proline metabolism_Homo sapiens_hsa003300.27894911
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27085708
138Pathways in cancer_Homo sapiens_hsa052000.27011431
139Adherens junction_Homo sapiens_hsa045200.26711683
140Influenza A_Homo sapiens_hsa051640.25821134
141Circadian rhythm_Homo sapiens_hsa047100.24413531
142Hematopoietic cell lineage_Homo sapiens_hsa046400.24274755

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