SLC7A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glycogen (starch) synthase activity (GO:2000465)5.73787747
2synaptic vesicle exocytosis (GO:0016079)5.66822761
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.58057796
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.42220888
5glutamate secretion (GO:0014047)5.03626294
6regulation of oxidative phosphorylation (GO:0002082)5.00491328
7vocalization behavior (GO:0071625)4.96901770
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.95983172
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.93532091
10proteasome assembly (GO:0043248)4.85842493
11regulation of synaptic vesicle exocytosis (GO:2000300)4.82579614
12protein localization to synapse (GO:0035418)4.57131409
13regulation of glutamate receptor signaling pathway (GO:1900449)4.52478674
14gamma-aminobutyric acid transport (GO:0015812)4.52350048
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.46923021
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.44894670
17regulation of synaptic vesicle transport (GO:1902803)4.35739743
18synaptic vesicle maturation (GO:0016188)4.33685804
19response to dietary excess (GO:0002021)4.32275100
20synaptic transmission, glutamatergic (GO:0035249)4.31616534
21neuron cell-cell adhesion (GO:0007158)4.31403662
22neuron-neuron synaptic transmission (GO:0007270)4.29706408
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.27824062
24estrogen biosynthetic process (GO:0006703)4.15885018
25glutamate receptor signaling pathway (GO:0007215)4.12213322
26neurotransmitter-gated ion channel clustering (GO:0072578)4.12102394
27neuronal action potential propagation (GO:0019227)4.10292948
28melanin biosynthetic process (GO:0042438)4.09139816
29negative regulation of synaptic transmission, GABAergic (GO:0032229)4.03297773
30positive regulation of neurotransmitter secretion (GO:0001956)4.03170097
31gamma-aminobutyric acid signaling pathway (GO:0007214)4.00740393
32establishment of protein localization to mitochondrial membrane (GO:0090151)4.00094913
33neurotransmitter secretion (GO:0007269)3.96635374
34energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.94285583
35ATP hydrolysis coupled proton transport (GO:0015991)3.94285583
36amyloid precursor protein catabolic process (GO:0042987)3.93946035
37locomotory exploration behavior (GO:0035641)3.91908158
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.87728481
39long-term synaptic potentiation (GO:0060291)3.86261058
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.85291739
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.84016606
42response to histamine (GO:0034776)3.82582553
43regulation of cellular respiration (GO:0043457)3.82120175
44postsynaptic membrane organization (GO:0001941)3.81623431
45presynaptic membrane assembly (GO:0097105)3.80335523
46regulation of neuronal synaptic plasticity (GO:0048168)3.76398256
47positive regulation of neurotransmitter transport (GO:0051590)3.72811673
48regulation of postsynaptic membrane potential (GO:0060078)3.69084850
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67795718
50regulation of synapse structural plasticity (GO:0051823)3.67735493
51transferrin transport (GO:0033572)3.67599441
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.65842981
53positive regulation of membrane potential (GO:0045838)3.58650686
54motile cilium assembly (GO:0044458)3.56932377
55presynaptic membrane organization (GO:0097090)3.56123781
56regulation of glutamate secretion (GO:0014048)3.55850521
57amyloid precursor protein metabolic process (GO:0042982)3.53515600
58regulation of synaptic plasticity (GO:0048167)3.51127810
59positive regulation of synapse maturation (GO:0090129)3.48962904
60exploration behavior (GO:0035640)3.48945003
61melanin metabolic process (GO:0006582)3.46246431
62female mating behavior (GO:0060180)3.45577832
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44466258
64secondary metabolite biosynthetic process (GO:0044550)3.41138664
65trivalent inorganic cation transport (GO:0072512)3.40580112
66ferric iron transport (GO:0015682)3.40580112
67regulation of neurotransmitter secretion (GO:0046928)3.40038025
68epithelial cilium movement (GO:0003351)3.39643233
69regulation of female receptivity (GO:0045924)3.38642687
70detection of calcium ion (GO:0005513)3.36493755
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.35852294
72adult feeding behavior (GO:0008343)3.34725517
73regulation of mitochondrial translation (GO:0070129)3.34248455
74proline transport (GO:0015824)3.34108087
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30769868
76neurotransmitter transport (GO:0006836)3.30319845
77synaptic vesicle endocytosis (GO:0048488)3.30236175
78long-term memory (GO:0007616)3.27648249
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.26514639
80galactose catabolic process (GO:0019388)3.24322348
81regulation of vesicle fusion (GO:0031338)3.22671303
82behavioral response to cocaine (GO:0048148)3.22011421
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21718108
84startle response (GO:0001964)3.21564209
85behavioral fear response (GO:0001662)3.19870541
86behavioral defense response (GO:0002209)3.19870541
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18991808
88positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17003814
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16500718
90neuron recognition (GO:0008038)3.16235415
91respiratory electron transport chain (GO:0022904)3.15256665
92electron transport chain (GO:0022900)3.13518148
93regulation of neurotransmitter transport (GO:0051588)3.12222069
94long term synaptic depression (GO:0060292)3.10675923
95fear response (GO:0042596)3.09760278
96positive regulation of synaptic transmission (GO:0050806)3.09547842
97serotonin metabolic process (GO:0042428)3.07421716
98synaptic transmission, dopaminergic (GO:0001963)3.04468789
99regulation of neurotransmitter levels (GO:0001505)3.04408809
100membrane depolarization (GO:0051899)3.01203283
101behavioral response to nicotine (GO:0035095)3.00075126
102calcium ion-dependent exocytosis (GO:0017156)2.99089253
103negative regulation of amino acid transport (GO:0051956)2.97358905
104innervation (GO:0060384)2.96028312
105relaxation of smooth muscle (GO:0044557)2.95960739
106synaptic transmission (GO:0007268)2.95883239
107establishment of synaptic vesicle localization (GO:0097480)2.95705572
108synaptic vesicle transport (GO:0048489)2.95705572
109toxin metabolic process (GO:0009404)2.95310172
110mechanosensory behavior (GO:0007638)2.95162048
111learning (GO:0007612)2.94179356
112regulation of synaptic transmission (GO:0050804)2.91951392
113protein polyglutamylation (GO:0018095)2.90583923
114protein localization to cilium (GO:0061512)2.90529852
115cellular response to ammonium ion (GO:0071242)2.89177703
116ATP synthesis coupled proton transport (GO:0015986)2.88948790
117energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88948790
118activation of protein kinase A activity (GO:0034199)2.88830356
119transmission of nerve impulse (GO:0019226)2.87349823
120regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.87117868
121inositol phosphate catabolic process (GO:0071545)2.85535020
122regulation of exocytosis (GO:0017157)2.83747644
123membrane hyperpolarization (GO:0060081)2.83469411
124regulation of calcium ion-dependent exocytosis (GO:0017158)2.83270989
125positive regulation of glycogen biosynthetic process (GO:0045725)2.82590230
126hydrogen ion transmembrane transport (GO:1902600)2.82483705
127regulation of transforming growth factor beta2 production (GO:0032909)2.82091417
128cellular potassium ion homeostasis (GO:0030007)2.81888311
129alanine transport (GO:0032328)2.80832933
130auditory behavior (GO:0031223)2.80304638
131response to auditory stimulus (GO:0010996)2.79971044
132striatum development (GO:0021756)2.79152353
133negative regulation of dendrite morphogenesis (GO:0050774)2.79148387
134glutathione derivative biosynthetic process (GO:1901687)2.79091890
135glutathione derivative metabolic process (GO:1901685)2.79091890
136cilium movement (GO:0003341)2.78763705
137regulation of synapse maturation (GO:0090128)2.78757930
138positive regulation of glycogen metabolic process (GO:0070875)2.78631693
139positive regulation of meiotic cell cycle (GO:0051446)2.76690869
140positive regulation of protein depolymerization (GO:1901881)2.70569571
141skin morphogenesis (GO:0043589)2.69498152
142dorsal/ventral neural tube patterning (GO:0021904)2.67222549
143social behavior (GO:0035176)2.65324063
144intraspecies interaction between organisms (GO:0051703)2.65324063
145nitric oxide biosynthetic process (GO:0006809)2.65303911
146negative regulation of receptor activity (GO:2000272)2.61530881
147negative regulation of microtubule polymerization (GO:0031115)2.57246053
148galactose metabolic process (GO:0006012)2.53600769
149proton transport (GO:0015992)2.53066011
150cardiac right ventricle morphogenesis (GO:0003215)2.52001271
151androgen biosynthetic process (GO:0006702)2.51979459
152cGMP biosynthetic process (GO:0006182)2.50838070
153epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49162563
154spinal cord motor neuron differentiation (GO:0021522)2.48340901
155hydrogen transport (GO:0006818)2.48161016
156regulation of energy homeostasis (GO:2000505)2.44948772
157regulation of cellular amino acid metabolic process (GO:0006521)2.44420154
158ribonucleoprotein complex disassembly (GO:0032988)2.44010036
159positive regulation of catecholamine secretion (GO:0033605)2.41922233
160axonemal dynein complex assembly (GO:0070286)2.41459750
161regulation of dopamine secretion (GO:0014059)2.40993652
162intracellular protein transmembrane import (GO:0044743)2.39528129
163keratinocyte development (GO:0003334)2.37547122
164negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.36890982
165spinal cord association neuron differentiation (GO:0021527)2.36719994
166* basic amino acid transport (GO:0015802)2.35678679
167cell migration in hindbrain (GO:0021535)2.34940705
168inner mitochondrial membrane organization (GO:0007007)2.31492551
169phenol-containing compound biosynthetic process (GO:0046189)2.30358703
170positive regulation of mitochondrial fission (GO:0090141)2.28094909
171ventricular septum development (GO:0003281)2.27053666
172positive regulation of TOR signaling (GO:0032008)2.25099836
173regulation of catecholamine metabolic process (GO:0042069)2.24725673
174regulation of dopamine metabolic process (GO:0042053)2.24725673
175placenta development (GO:0001890)2.23962962
176potassium ion import (GO:0010107)2.22025078
177regulation of feeding behavior (GO:0060259)2.21977849
178negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.21632267
179negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.20400695
180insulin secretion (GO:0030073)2.19492381
181cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.18738885
182glucocorticoid biosynthetic process (GO:0006704)2.18218642
183positive regulation of cGMP biosynthetic process (GO:0030828)2.16897395
184inositol phosphate dephosphorylation (GO:0046855)2.15777068
185phosphorylated carbohydrate dephosphorylation (GO:0046838)2.15777068
186secondary metabolic process (GO:0019748)2.13982088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.15588366
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.94513847
3GBX2_23144817_ChIP-Seq_PC3_Human4.29307086
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24550247
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11004202
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96275740
7REST_21632747_ChIP-Seq_MESCs_Mouse2.88367910
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67528741
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58361323
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.53672931
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51038079
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47915462
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45996323
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45102431
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45102431
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.44334814
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41768953
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.41389121
19TAF15_26573619_Chip-Seq_HEK293_Human2.40577218
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33444967
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32920530
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22207527
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.19432396
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10141873
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08934732
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03694992
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.02140124
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99394923
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.94008633
30DROSHA_22980978_ChIP-Seq_HELA_Human1.90262762
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85548425
32SMAD4_21799915_ChIP-Seq_A2780_Human1.81279150
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76731705
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72661964
35ZNF274_21170338_ChIP-Seq_K562_Hela1.71847417
36P300_19829295_ChIP-Seq_ESCs_Human1.69869729
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.69178708
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64962645
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61983858
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.61146792
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58267944
42AR_21572438_ChIP-Seq_LNCaP_Human1.57564701
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56714681
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56535705
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49697236
46AR_25329375_ChIP-Seq_VCAP_Human1.46739631
47CTCF_27219007_Chip-Seq_Bcells_Human1.42414639
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.41217993
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40365059
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40135201
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39913907
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39644102
53FUS_26573619_Chip-Seq_HEK293_Human1.38956028
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38536843
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36994893
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.35901064
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34988636
58IGF1R_20145208_ChIP-Seq_DFB_Human1.34784239
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.34267003
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34000171
61VDR_22108803_ChIP-Seq_LS180_Human1.32417754
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.29680987
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28103098
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28094780
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.27505038
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23391835
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.23157030
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19626646
69RNF2_27304074_Chip-Seq_NSC_Mouse1.18512195
70EOMES_21245162_ChIP-Seq_HESCs_Human1.18361430
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16200289
72TCF4_23295773_ChIP-Seq_U87_Human1.15494720
73STAT3_23295773_ChIP-Seq_U87_Human1.14646386
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.13982580
75HTT_18923047_ChIP-ChIP_STHdh_Human1.13403681
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11389536
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10462406
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.09562754
79RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08605711
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08098159
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07941104
82RUNX2_22187159_ChIP-Seq_PCA_Human1.07210321
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06803214
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06362666
85* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06231934
86AR_19668381_ChIP-Seq_PC3_Human1.04232063
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.02980803
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02731678
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.02418264
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02094231
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00484399
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98645394
93BCAT_22108803_ChIP-Seq_LS180_Human0.98530311
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98312318
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.97383198
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97254832
97ER_23166858_ChIP-Seq_MCF-7_Human0.97178036
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.95918298
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95550737
100RING1B_27294783_Chip-Seq_ESCs_Mouse0.95473188
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95114523
102CDX2_20551321_ChIP-Seq_CACO-2_Human0.94996008
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.94649520
104TBL1_22424771_ChIP-Seq_293T_Human0.94159185
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94125809
106JUN_21703547_ChIP-Seq_K562_Human0.93750123
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91429371
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91027247
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90763116
110AHR_22903824_ChIP-Seq_MCF-7_Human0.89654087
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89275132
112TET1_21490601_ChIP-Seq_MESCs_Mouse0.89015086
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.88783971
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.88636177
115JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88598373
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88597029
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87459714
118RAC3_21632823_ChIP-Seq_H3396_Human0.87378005
119KDM2B_26808549_Chip-Seq_REH_Human0.87195281
120SMC4_20622854_ChIP-Seq_HELA_Human0.87060007
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86425927
122MYC_19829295_ChIP-Seq_ESCs_Human0.85375726
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84435378
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84317086
125LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84185459
126* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84006741
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83762290
128WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83246716
129P53_22387025_ChIP-Seq_ESCs_Mouse0.82665841
130CBP_20019798_ChIP-Seq_JUKART_Human0.82342345
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82342345
132* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82155588
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81914100
134TCF4_22108803_ChIP-Seq_LS180_Human0.81157744
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80989426
136SMAD_19615063_ChIP-ChIP_OVARY_Human0.80552513
137SOX2_21211035_ChIP-Seq_LN229_Human0.79566632
138ERA_21632823_ChIP-Seq_H3396_Human0.77953324
139SMAD4_21741376_ChIP-Seq_EPCs_Human0.77805219
140* TP63_22573176_ChIP-Seq_HFKS_Human0.77145753
141HOXB7_26014856_ChIP-Seq_BT474_Human0.76474086
142ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76075040
143RXR_22108803_ChIP-Seq_LS180_Human0.75837245

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.49639817
2MP0003880_abnormal_central_pattern5.03952130
3MP0003635_abnormal_synaptic_transmissio3.92331282
4MP0009745_abnormal_behavioral_response3.43037690
5MP0004270_analgesia3.33683986
6MP0001968_abnormal_touch/_nociception3.24631508
7MP0005670_abnormal_white_adipose3.22373146
8MP0002063_abnormal_learning/memory/cond3.21520456
9MP0000566_synostosis3.18436510
10MP0002064_seizures3.06267208
11MP0002736_abnormal_nociception_after3.02172183
12MP0002822_catalepsy2.83519948
13MP0002572_abnormal_emotion/affect_behav2.79477781
14MP0009046_muscle_twitch2.74992496
15MP0002734_abnormal_mechanical_nocicepti2.60325492
16MP0003806_abnormal_nucleotide_metabolis2.57553558
17MP0002272_abnormal_nervous_system2.51912969
18MP0009780_abnormal_chondrocyte_physiolo2.43070438
19MP0002735_abnormal_chemical_nociception2.39360519
20MP0001501_abnormal_sleep_pattern2.35581874
21MP0005377_hearing/vestibular/ear_phenot2.28930569
22MP0003878_abnormal_ear_physiology2.28930569
23MP0001440_abnormal_grooming_behavior2.24535710
24MP0001486_abnormal_startle_reflex2.19901842
25MP0003136_yellow_coat_color2.16187205
26MP0005646_abnormal_pituitary_gland2.15906121
27MP0010386_abnormal_urinary_bladder2.11605516
28MP0003879_abnormal_hair_cell2.06924781
29MP0002909_abnormal_adrenal_gland2.04311653
30MP0001970_abnormal_pain_threshold2.01914968
31MP0002733_abnormal_thermal_nociception1.99733170
32MP0002067_abnormal_sensory_capabilities1.96810394
33MP0005171_absent_coat_pigmentation1.96033477
34MP0001529_abnormal_vocalization1.95381972
35MP0002876_abnormal_thyroid_physiology1.95037072
36MP0006276_abnormal_autonomic_nervous1.83445136
37MP0002837_dystrophic_cardiac_calcinosis1.81978839
38MP0003011_delayed_dark_adaptation1.81794304
39MP0005423_abnormal_somatic_nervous1.77893330
40MP0002557_abnormal_social/conspecific_i1.70211197
41MP0004019_abnormal_vitamin_homeostasis1.64637147
42MP0004924_abnormal_behavior1.62980746
43MP0005386_behavior/neurological_phenoty1.62980746
44MP0002184_abnormal_innervation1.61487746
45MP0008569_lethality_at_weaning1.60898214
46MP0000537_abnormal_urethra_morphology1.58825386
47MP0004133_heterotaxia1.56494578
48MP0001188_hyperpigmentation1.54810155
49MP0001984_abnormal_olfaction1.53862640
50MP0008875_abnormal_xenobiotic_pharmacok1.51758008
51MP0001905_abnormal_dopamine_level1.50303514
52MP0005645_abnormal_hypothalamus_physiol1.50227860
53MP0003890_abnormal_embryonic-extraembry1.49915919
54MP0003329_amyloid_beta_deposits1.49650969
55MP0003315_abnormal_perineum_morphology1.47124003
56MP0004043_abnormal_pH_regulation1.45545867
57MP0003183_abnormal_peptide_metabolism1.45274619
58MP0003787_abnormal_imprinting1.44756615
59MP0004811_abnormal_neuron_physiology1.42936008
60MP0003938_abnormal_ear_development1.39839943
61MP0005408_hypopigmentation1.37780491
62MP0000372_irregular_coat_pigmentation1.36992660
63MP0001664_abnormal_digestion1.36371098
64MP0001502_abnormal_circadian_rhythm1.33124487
65MP0003122_maternal_imprinting1.30041268
66MP0000647_abnormal_sebaceous_gland1.29858287
67MP0000778_abnormal_nervous_system1.29020577
68MP0000955_abnormal_spinal_cord1.27708246
69MP0002066_abnormal_motor_capabilities/c1.25793682
70MP0000013_abnormal_adipose_tissue1.24812915
71MP0001727_abnormal_embryo_implantation1.23977216
72MP0004858_abnormal_nervous_system1.22815178
73MP0004142_abnormal_muscle_tone1.22121904
74MP0003633_abnormal_nervous_system1.21659438
75MP0002882_abnormal_neuron_morphology1.19656403
76MP0000015_abnormal_ear_pigmentation1.19074230
77MP0002938_white_spotting1.18528168
78MP0008872_abnormal_physiological_respon1.08062400
79MP0005075_abnormal_melanosome_morpholog1.06769893
80MP0005551_abnormal_eye_electrophysiolog1.03009355
81MP0005174_abnormal_tail_pigmentation1.02518651
82MP0002069_abnormal_eating/drinking_beha0.99256590
83MP0005535_abnormal_body_temperature0.98908361
84MP0003186_abnormal_redox_activity0.98130181
85MP0002229_neurodegeneration0.98050372
86MP0001765_abnormal_ion_homeostasis0.96262310
87MP0008004_abnormal_stomach_pH0.95962820
88MP0003631_nervous_system_phenotype0.95374694
89MP0004885_abnormal_endolymph0.93081835
90MP0000026_abnormal_inner_ear0.91371576
91MP0004145_abnormal_muscle_electrophysio0.91315515
92MP0005379_endocrine/exocrine_gland_phen0.90910424
93MP0009379_abnormal_foot_pigmentation0.90555364
94MP0004085_abnormal_heartbeat0.87556687
95MP0008874_decreased_physiological_sensi0.86635856
96MP0005332_abnormal_amino_acid0.86157004
97MP0004147_increased_porphyrin_level0.86142390
98MP0005310_abnormal_salivary_gland0.86004210
99MP0005666_abnormal_adipose_tissue0.85947503
100MP0000631_abnormal_neuroendocrine_gland0.85756718
101MP0009697_abnormal_copulation0.85451463
102MP0010368_abnormal_lymphatic_system0.84982696
103MP0001963_abnormal_hearing_physiology0.84856382
104MP0002152_abnormal_brain_morphology0.84003853
105MP0000751_myopathy0.83431628
106MP0005410_abnormal_fertilization0.81089710
107MP0001661_extended_life_span0.79867887
108MP0002638_abnormal_pupillary_reflex0.78642542
109MP0002693_abnormal_pancreas_physiology0.77529759
110MP0003567_abnormal_fetal_cardiomyocyte0.76763281
111MP0002090_abnormal_vision0.76444509
112MP0003693_abnormal_embryo_hatching0.76123464
113MP0003632_abnormal_nervous_system0.75127495
114MP0004185_abnormal_adipocyte_glucose0.74708027
115MP0000681_abnormal_thyroid_gland0.73556571
116MP0000569_abnormal_digit_pigmentation0.71694404
117MP0000427_abnormal_hair_cycle0.70033327
118MP0002160_abnormal_reproductive_system0.69508024
119MP0004215_abnormal_myocardial_fiber0.68832610
120MP0005266_abnormal_metabolism0.68662084
121MP0002295_abnormal_pulmonary_circulatio0.64590454
122MP0001756_abnormal_urination0.63790688
123MP0000604_amyloidosis0.63577064
124MP0005394_taste/olfaction_phenotype0.63291513
125MP0005499_abnormal_olfactory_system0.63291513
126MP0005375_adipose_tissue_phenotype0.62921180
127MP0005253_abnormal_eye_physiology0.62679512
128MP0006072_abnormal_retinal_apoptosis0.62446791
129MP0005330_cardiomyopathy0.62212812
130MP0010030_abnormal_orbit_morphology0.62074282
131MP0002752_abnormal_somatic_nervous0.61867684
132MP0001485_abnormal_pinna_reflex0.59980698
133MP0004742_abnormal_vestibular_system0.59587129
134MP0001944_abnormal_pancreas_morphology0.57739948
135MP0003953_abnormal_hormone_level0.57072798
136MP0003283_abnormal_digestive_organ0.56991004
137MP0001986_abnormal_taste_sensitivity0.56381694
138MP0004484_altered_response_of0.56354295
139MP0006035_abnormal_mitochondrial_morpho0.55692511
140MP0005084_abnormal_gallbladder_morpholo0.54612466
141MP0002078_abnormal_glucose_homeostasis0.52803092
142MP0005448_abnormal_energy_balance0.52214777
143MP0003956_abnormal_body_size0.52103408
144MP0001177_atelectasis0.51943191
145MP0000230_abnormal_systemic_arterial0.51066354
146MP0003634_abnormal_glial_cell0.50510733

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.80346678
2Visual hallucinations (HP:0002367)5.47348241
3Epileptic encephalopathy (HP:0200134)5.37450619
4Myokymia (HP:0002411)5.31095951
5Atonic seizures (HP:0010819)5.05376936
6Focal seizures (HP:0007359)4.96933927
7Febrile seizures (HP:0002373)4.15600727
8Absence seizures (HP:0002121)4.09151538
9Hyperventilation (HP:0002883)3.98602319
10Dialeptic seizures (HP:0011146)3.81341578
11Aplasia cutis congenita (HP:0001057)3.68806183
12Generalized tonic-clonic seizures (HP:0002069)3.60651642
13Abnormality of alanine metabolism (HP:0010916)3.58480590
14Hyperalaninemia (HP:0003348)3.58480590
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.58480590
16Progressive cerebellar ataxia (HP:0002073)3.56156748
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.48234622
18Abnormal respiratory epithelium morphology (HP:0012253)3.26906703
19Abnormal respiratory motile cilium morphology (HP:0005938)3.26906703
20Abnormal ciliary motility (HP:0012262)3.20892756
21Increased circulating renin level (HP:0000848)3.20357368
22Abnormality of the dental root (HP:0006486)3.13671972
23Taurodontia (HP:0000679)3.13671972
24Abnormality of permanent molar morphology (HP:0011071)3.13671972
25Epileptiform EEG discharges (HP:0011182)3.04540902
26Gaze-evoked nystagmus (HP:0000640)3.00221119
27Amblyopia (HP:0000646)2.98488485
28Truncal ataxia (HP:0002078)2.95650235
29Anxiety (HP:0000739)2.94996029
30Abnormality of molar morphology (HP:0011070)2.94687547
31Abnormality of molar (HP:0011077)2.94687547
32Broad-based gait (HP:0002136)2.94477709
33Akinesia (HP:0002304)2.81889508
34Depression (HP:0000716)2.79705592
35Impaired vibration sensation in the lower limbs (HP:0002166)2.79430588
36Impaired smooth pursuit (HP:0007772)2.78271529
37Ankle clonus (HP:0011448)2.76848257
38Facial diplegia (HP:0001349)2.75941134
39Abnormality of the dental pulp (HP:0006479)2.75375657
40Poor eye contact (HP:0000817)2.74587943
41Protruding tongue (HP:0010808)2.72204979
42EEG with generalized epileptiform discharges (HP:0011198)2.70566892
43Abnormal eating behavior (HP:0100738)2.68509126
44Abnormal respiratory motile cilium physiology (HP:0012261)2.67063742
45Supranuclear gaze palsy (HP:0000605)2.64901830
46Abnormal mitochondria in muscle tissue (HP:0008316)2.62654356
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.61955863
48Hypoplasia of the fovea (HP:0007750)2.61955863
49Hypokinesia (HP:0002375)2.61818149
50Acute necrotizing encephalopathy (HP:0006965)2.60877923
51Poor suck (HP:0002033)2.59180986
52Gait imbalance (HP:0002141)2.57832047
53Retinal dysplasia (HP:0007973)2.55415031
54Pheochromocytoma (HP:0002666)2.53096256
55Hypsarrhythmia (HP:0002521)2.48676462
56Inability to walk (HP:0002540)2.47987423
57Abnormal hair whorl (HP:0010721)2.47523924
58Rhinitis (HP:0012384)2.46958207
59Bradykinesia (HP:0002067)2.46168042
60Diminished movement (HP:0002374)2.45743533
61Impaired social interactions (HP:0000735)2.42053498
62Abnormal social behavior (HP:0012433)2.42053498
63Dysmetria (HP:0001310)2.42003566
64Type II lissencephaly (HP:0007260)2.40957890
65Progressive inability to walk (HP:0002505)2.39421566
66Dysdiadochokinesis (HP:0002075)2.38254647
67Neuroendocrine neoplasm (HP:0100634)2.38057583
68Congenital primary aphakia (HP:0007707)2.37473675
69Medial flaring of the eyebrow (HP:0010747)2.36884509
70Resting tremor (HP:0002322)2.36289605
71Polyphagia (HP:0002591)2.35003111
72Nephrogenic diabetes insipidus (HP:0009806)2.32800670
73Hypothermia (HP:0002045)2.32558226
74Syncope (HP:0001279)2.31677120
75Scanning speech (HP:0002168)2.31199652
76Excessive salivation (HP:0003781)2.31171252
77Drooling (HP:0002307)2.31171252
78Delusions (HP:0000746)2.29337549
79Progressive macrocephaly (HP:0004481)2.29019331
80Popliteal pterygium (HP:0009756)2.28627298
81Renal tubular acidosis (HP:0001947)2.27107444
82Oligomenorrhea (HP:0000876)2.26733804
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.26701191
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26701191
85Dysmetric saccades (HP:0000641)2.26339081
86Postural instability (HP:0002172)2.26243186
87Ileus (HP:0002595)2.25200562
88Cerebral inclusion bodies (HP:0100314)2.24489964
89Hypomagnesemia (HP:0002917)2.22413086
90Mitochondrial inheritance (HP:0001427)2.22334655
91Urinary bladder sphincter dysfunction (HP:0002839)2.22229515
92Prolonged QT interval (HP:0001657)2.22193191
93Action tremor (HP:0002345)2.21645679
94Hyperthyroidism (HP:0000836)2.21644515
95Abnormality of ocular smooth pursuit (HP:0000617)2.19626207
96Focal dystonia (HP:0004373)2.15591529
97Abnormality of the aortic arch (HP:0012303)2.13586121
98Blue irides (HP:0000635)2.12941449
99Cortical visual impairment (HP:0100704)2.12339774
100Male pseudohermaphroditism (HP:0000037)2.12232950
101Abnormality of magnesium homeostasis (HP:0004921)2.12065067
102Hepatocellular necrosis (HP:0001404)2.12061222
103Disproportionate short-trunk short stature (HP:0003521)2.10272996
104Congenital stationary night blindness (HP:0007642)2.09269708
105Diplopia (HP:0000651)2.08576250
106Abnormality of binocular vision (HP:0011514)2.08576250
107Thyroid-stimulating hormone excess (HP:0002925)2.07706445
108Abnormality of the fovea (HP:0000493)2.07411513
109Torticollis (HP:0000473)2.07316212
110Stereotypic behavior (HP:0000733)2.06202453
111Limb dystonia (HP:0002451)2.06016582
112Abnormal drinking behavior (HP:0030082)2.05685276
113Polydipsia (HP:0001959)2.05685276
114Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04301163
115Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04301163
116Agitation (HP:0000713)2.03793328
117Failure to thrive in infancy (HP:0001531)2.03462969
118Cerebellar dysplasia (HP:0007033)2.02613361
119Psychosis (HP:0000709)2.02539045
120Absent speech (HP:0001344)2.01373944
121Impaired vibratory sensation (HP:0002495)2.01087242
122Median cleft lip (HP:0000161)2.00550264
123Turricephaly (HP:0000262)2.00379807
124Unsteady gait (HP:0002317)2.00200063
125Hemiparesis (HP:0001269)2.00087535
126Abnormality of renin-angiotensin system (HP:0000847)1.99122679
127Adrenal hypoplasia (HP:0000835)1.98377907
128Hypoventilation (HP:0002791)1.98344827
129Mutism (HP:0002300)1.97355294
130Opisthotonus (HP:0002179)1.97291825
131Optic disc pallor (HP:0000543)1.96244454
132Posterior embryotoxon (HP:0000627)1.95452926
133Craniofacial dystonia (HP:0012179)1.95342799
134Acute encephalopathy (HP:0006846)1.95157328
135Aplasia/Hypoplasia of the macula (HP:0008059)1.95035296
136Aplastic anemia (HP:0001915)1.94975320
137Generalized myoclonic seizures (HP:0002123)1.94410578
138Amelogenesis imperfecta (HP:0000705)1.93635332
139Neurofibrillary tangles (HP:0002185)1.90445845
140Abnormality of the corticospinal tract (HP:0002492)1.89726081
141Abnormality of the line of Schwalbe (HP:0008048)1.89242055
142Spastic paraparesis (HP:0002313)1.88511893
143Spastic tetraparesis (HP:0001285)1.88428216
144Limb ataxia (HP:0002070)1.88361203
145Renal tubular dysfunction (HP:0000124)1.88282739
146Redundant skin (HP:0001582)1.87287142
147Status epilepticus (HP:0002133)1.87087329
148Abnormality of the lower motor neuron (HP:0002366)1.85313638
149Specific learning disability (HP:0001328)1.85166637
150Increased CSF lactate (HP:0002490)1.85133419
151Aplasia of the musculature (HP:0100854)1.84215085
152Nasal polyposis (HP:0100582)1.83601654
153Gout (HP:0001997)1.83233177
154Abnormality of the vitreous humor (HP:0004327)1.82440869
155Large for gestational age (HP:0001520)1.82379118
156Dynein arm defect of respiratory motile cilia (HP:0012255)1.81723223
157Absent/shortened dynein arms (HP:0200106)1.81723223
158Aplasia/Hypoplasia affecting the retina (HP:0008061)1.81289010
159Cerebral hypomyelination (HP:0006808)1.80217450
160Genetic anticipation (HP:0003743)1.79526805
161Spastic gait (HP:0002064)1.79297564
162Gait ataxia (HP:0002066)1.78412485
163Abnormality of dental color (HP:0011073)1.77601358
164Fetal akinesia sequence (HP:0001989)1.77336003
165Esotropia (HP:0000565)1.76790058
166Truncus arteriosus (HP:0001660)1.76146039
167Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75956116
168Hypoplasia of the uterus (HP:0000013)1.74488376
169Conjunctival hamartoma (HP:0100780)1.72037848
170Chronic bronchitis (HP:0004469)1.71726981
171Palpitations (HP:0001962)1.71191589
172Bilateral sensorineural hearing impairment (HP:0008619)1.70492305
173Abnormal pupillary function (HP:0007686)1.70084419
174Widely spaced teeth (HP:0000687)1.69318021
175Right ventricular cardiomyopathy (HP:0011663)1.68767218
176Aplasia/hypoplasia of the uterus (HP:0008684)1.67400011
177Neonatal onset (HP:0003623)1.66428769
178Hypokalemic alkalosis (HP:0001949)1.62293171
179Retinal atrophy (HP:0001105)1.62155608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K114.62283277
2EPHA44.41959455
3NTRK34.04212479
4CASK3.85605404
5MAP3K123.53970069
6MAP2K73.33092379
7MAP3K43.29206683
8CDK193.01613201
9DAPK22.73944267
10MAP3K92.62826261
11DAPK12.41877117
12RIPK42.38643330
13MINK12.17226163
14AKT32.10995140
15MAP2K42.07650412
16PLK21.92492498
17PRPF4B1.91853670
18TNIK1.80895350
19MARK31.78328426
20ARAF1.77331525
21MAP3K51.76283647
22GRK51.71838747
23WNK41.71414329
24STK391.54025312
25NME11.53209885
26MARK11.51522788
27KSR21.49645829
28LATS21.45071068
29CCNB11.43231780
30OXSR11.41301267
31SIK31.36993183
32CDK51.31647570
33KSR11.27461242
34MAP3K21.26495535
35NTRK21.23759648
36EPHA21.21744621
37PTK2B1.20261570
38CAMKK21.19741811
39NTRK11.18219032
40MAPK131.17619390
41DYRK21.17218845
42PRKCG1.12718616
43FES1.10295358
44LATS11.09434715
45CAMKK11.09142469
46BMPR21.07261480
47PAK61.05850488
48CAMK2A1.03868998
49CAMK11.02376795
50BCKDK0.98460137
51PNCK0.96351932
52CAMK2B0.94052854
53MAP3K130.92893734
54MYLK0.91955973
55BRAF0.88622635
56RAF10.83463621
57PRKD30.82393595
58FRK0.81249420
59WEE10.80272472
60PDK40.80002830
61PDK30.80002830
62MAP2K60.77110730
63STK38L0.76435022
64FER0.75252805
65EPHB20.74773486
66GRK70.74286164
67TSSK60.73259274
68MAPK150.72589618
69SGK4940.72139615
70SGK2230.72139615
71CDK180.71922996
72INSRR0.70591034
73FGR0.70028786
74PBK0.69622657
75MAP3K10.67845069
76TNK20.66386470
77SIK20.65449157
78CSNK1G20.65152529
79CDK150.64102623
80SGK20.63605959
81DYRK1A0.63472301
82PRKCE0.63433605
83CDK140.62500413
84MARK20.62031940
85CSNK1G30.59392597
86MUSK0.58535517
87GRK10.58468828
88ADRBK10.58112044
89ABL20.58069225
90DAPK30.56578831
91CDK11A0.56559793
92CAMK2D0.56527355
93RET0.56002253
94UHMK10.53946002
95PRKCI0.53441599
96MAP3K60.53312654
97CSNK1A1L0.52639926
98ADRBK20.52303323
99STK380.52022529
100PDK10.51375079
101PDK20.51214320
102MAP4K20.50814492
103MET0.50560928
104STK110.50400368
105MAP2K10.50303111
106SGK10.49933260
107PDPK10.47490977
108PAK30.46538693
109LMTK20.46469384
110AKT20.46367600
111WNK30.46199614
112CSNK1G10.45260457
113TIE10.40787832
114CAMK2G0.40107416
115BMPR1B0.39720322
116MAPKAPK50.39109307
117TAOK30.37840051
118PINK10.36849026
119GRK60.36771259
120SCYL20.35320076
121MST40.35026961
122BCR0.34994645
123PAK10.34401032
124PRKACA0.33638268
125PHKG10.33417451
126PHKG20.33417451
127ILK0.33182783
128MAP3K70.32627067
129PRKCH0.31832358
130RPS6KA50.31798581
131MST1R0.31744617
132STK160.31516258
133TAOK10.28953280
134PRKCA0.28943895
135OBSCN0.28832279
136PRKG10.27603772
137BUB10.24059536
138PRKCZ0.22298795
139TGFBR10.20057109
140ROCK10.17599754
141PRKG20.15221690
142NEK20.14500216
143CDK80.14444377
144CSNK1A10.13789972
145NME20.13257507

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.03623145
2Synaptic vesicle cycle_Homo sapiens_hsa047213.92824047
3Collecting duct acid secretion_Homo sapiens_hsa049663.14337283
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74838572
5Olfactory transduction_Homo sapiens_hsa047402.63268459
6Long-term potentiation_Homo sapiens_hsa047202.58858237
7Amphetamine addiction_Homo sapiens_hsa050312.58845279
8Circadian entrainment_Homo sapiens_hsa047132.56592804
9GABAergic synapse_Homo sapiens_hsa047272.45599063
10Morphine addiction_Homo sapiens_hsa050322.45490826
11Vibrio cholerae infection_Homo sapiens_hsa051102.33521751
12Proteasome_Homo sapiens_hsa030502.31875550
13Glutamatergic synapse_Homo sapiens_hsa047242.27732354
14Insulin secretion_Homo sapiens_hsa049112.21554986
15Tyrosine metabolism_Homo sapiens_hsa003502.14717458
16Taste transduction_Homo sapiens_hsa047422.11702936
17Salivary secretion_Homo sapiens_hsa049702.07698507
18Dopaminergic synapse_Homo sapiens_hsa047282.06478672
19Phenylalanine metabolism_Homo sapiens_hsa003601.99345456
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89460840
21Oxidative phosphorylation_Homo sapiens_hsa001901.88713369
22Renin secretion_Homo sapiens_hsa049241.82377079
23Calcium signaling pathway_Homo sapiens_hsa040201.70126281
24Serotonergic synapse_Homo sapiens_hsa047261.66488814
25Gastric acid secretion_Homo sapiens_hsa049711.64619420
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60287702
27Cholinergic synapse_Homo sapiens_hsa047251.58610470
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57936999
29Cocaine addiction_Homo sapiens_hsa050301.57371668
30Ribosome_Homo sapiens_hsa030101.56826683
31Long-term depression_Homo sapiens_hsa047301.49052983
32Oxytocin signaling pathway_Homo sapiens_hsa049211.40485103
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37994500
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36888909
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36829417
36Alzheimers disease_Homo sapiens_hsa050101.34569923
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30176293
38Glutathione metabolism_Homo sapiens_hsa004801.29321272
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28600928
40Folate biosynthesis_Homo sapiens_hsa007901.27191134
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26992543
42Fatty acid elongation_Homo sapiens_hsa000621.26570589
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26078230
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24933812
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24085776
46Parkinsons disease_Homo sapiens_hsa050121.22906863
47Pancreatic secretion_Homo sapiens_hsa049721.22038207
48Chemical carcinogenesis_Homo sapiens_hsa052041.19103955
49cAMP signaling pathway_Homo sapiens_hsa040241.16515522
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14936941
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13029567
52GnRH signaling pathway_Homo sapiens_hsa049121.12710761
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11647459
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.08102708
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06929629
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05750175
57Cardiac muscle contraction_Homo sapiens_hsa042601.05459446
58Sphingolipid metabolism_Homo sapiens_hsa006001.05444613
59Gap junction_Homo sapiens_hsa045401.04113136
60Ovarian steroidogenesis_Homo sapiens_hsa049131.02212539
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96691969
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96393581
63Sulfur relay system_Homo sapiens_hsa041220.96328453
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94280922
65Protein export_Homo sapiens_hsa030600.92820161
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.92419169
67Tight junction_Homo sapiens_hsa045300.91759896
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91667465
69Histidine metabolism_Homo sapiens_hsa003400.89962957
70Phototransduction_Homo sapiens_hsa047440.88941534
71Peroxisome_Homo sapiens_hsa041460.88217549
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87684480
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86802464
74Type II diabetes mellitus_Homo sapiens_hsa049300.86503469
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85416990
76Nitrogen metabolism_Homo sapiens_hsa009100.84107695
77Rheumatoid arthritis_Homo sapiens_hsa053230.83169881
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80231150
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79362123
80Huntingtons disease_Homo sapiens_hsa050160.78370665
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78320805
82Estrogen signaling pathway_Homo sapiens_hsa049150.78138116
83Thyroid hormone synthesis_Homo sapiens_hsa049180.77797367
84Arginine biosynthesis_Homo sapiens_hsa002200.77028785
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74230745
86Steroid biosynthesis_Homo sapiens_hsa001000.71388883
87Metabolic pathways_Homo sapiens_hsa011000.71298120
88Melanogenesis_Homo sapiens_hsa049160.69203942
89Hedgehog signaling pathway_Homo sapiens_hsa043400.68158892
90Butanoate metabolism_Homo sapiens_hsa006500.67409237
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65486941
92PPAR signaling pathway_Homo sapiens_hsa033200.65399525
93Mineral absorption_Homo sapiens_hsa049780.62377965
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61968221
95ErbB signaling pathway_Homo sapiens_hsa040120.61882080
96Type I diabetes mellitus_Homo sapiens_hsa049400.61755512
97Glioma_Homo sapiens_hsa052140.61274657
98N-Glycan biosynthesis_Homo sapiens_hsa005100.60172784
99Glucagon signaling pathway_Homo sapiens_hsa049220.58874278
100Inositol phosphate metabolism_Homo sapiens_hsa005620.58638883
101Tryptophan metabolism_Homo sapiens_hsa003800.57520411
102Axon guidance_Homo sapiens_hsa043600.56538435
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53965378
104Oocyte meiosis_Homo sapiens_hsa041140.52711294
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52409680
106Sulfur metabolism_Homo sapiens_hsa009200.51208374
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.50354524
108Phagosome_Homo sapiens_hsa041450.50220040
109Arginine and proline metabolism_Homo sapiens_hsa003300.50021645
110Regulation of autophagy_Homo sapiens_hsa041400.48019249
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.47934740
112Pyruvate metabolism_Homo sapiens_hsa006200.46254666
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43629426
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43501876
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43458441
116Circadian rhythm_Homo sapiens_hsa047100.43181401
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42969129
118Hippo signaling pathway_Homo sapiens_hsa043900.41812919
119Fat digestion and absorption_Homo sapiens_hsa049750.39727515
120Alcoholism_Homo sapiens_hsa050340.39475871
121ECM-receptor interaction_Homo sapiens_hsa045120.38371845
122Fructose and mannose metabolism_Homo sapiens_hsa000510.38036662
123Purine metabolism_Homo sapiens_hsa002300.36523506
124MAPK signaling pathway_Homo sapiens_hsa040100.35782932
125Basal transcription factors_Homo sapiens_hsa030220.35312804
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35010218
127Fatty acid degradation_Homo sapiens_hsa000710.34478140
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33126647
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32740733
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.32280529
131Choline metabolism in cancer_Homo sapiens_hsa052310.30734141
132Dilated cardiomyopathy_Homo sapiens_hsa054140.30130457
133Ras signaling pathway_Homo sapiens_hsa040140.29835398
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.26291778
135Prion diseases_Homo sapiens_hsa050200.24857160
136African trypanosomiasis_Homo sapiens_hsa051430.24207283
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21662383
138VEGF signaling pathway_Homo sapiens_hsa043700.21494490
139Insulin signaling pathway_Homo sapiens_hsa049100.21225005
140Galactose metabolism_Homo sapiens_hsa000520.21050157
141Lysosome_Homo sapiens_hsa041420.20781592
142Rap1 signaling pathway_Homo sapiens_hsa040150.20260360
143Other glycan degradation_Homo sapiens_hsa005110.18890902
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.16632554

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