SLC7A14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is predicted to encode a glycosylated, cationic amino acid transporter protein with 14 transmembrane domains. This gene is primarily expressed in skin fibroblasts, neural tissue, and primary endothelial cells and its protein is predicted to mediate lysosomal uptake of cationic amino acids. Mutations in this gene are associated with autosomal recessive retinitis pigmentosa. In mice, this gene is expressed in the photoreceptor layer of the retina where its expression increases over the course of retinal development and persists in the mature retina. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.58788902
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.37595593
3synaptic vesicle maturation (GO:0016188)4.88061653
4synaptic vesicle exocytosis (GO:0016079)4.59788418
5regulation of synaptic vesicle exocytosis (GO:2000300)4.48818124
6locomotory exploration behavior (GO:0035641)4.38993736
7detection of calcium ion (GO:0005513)4.26370559
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.16244346
9Golgi transport vesicle coating (GO:0048200)4.12336806
10COPI coating of Golgi vesicle (GO:0048205)4.12336806
11regulation of synaptic vesicle transport (GO:1902803)4.03693714
12vocalization behavior (GO:0071625)4.03096374
13negative regulation of synaptic transmission, GABAergic (GO:0032229)3.97105124
14glutamate secretion (GO:0014047)3.96579722
15neuronal action potential propagation (GO:0019227)3.95543704
16postsynaptic membrane organization (GO:0001941)3.84615767
17neurotransmitter secretion (GO:0007269)3.82687644
18negative regulation of cytosolic calcium ion concentration (GO:0051481)3.80674717
19behavioral response to nicotine (GO:0035095)3.78981482
20insulin secretion (GO:0030073)3.76865440
21regulation of glutamate receptor signaling pathway (GO:1900449)3.73984953
22neuron cell-cell adhesion (GO:0007158)3.73123987
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.72361245
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70584168
25regulation of neuronal synaptic plasticity (GO:0048168)3.70013454
26serotonin metabolic process (GO:0042428)3.65209605
27positive regulation of synaptic transmission, GABAergic (GO:0032230)3.60939898
28chemosensory behavior (GO:0007635)3.58891129
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.58630877
30presynaptic membrane assembly (GO:0097105)3.54023942
31regulation of neurotransmitter uptake (GO:0051580)3.53235773
32axon ensheathment in central nervous system (GO:0032291)3.52127818
33central nervous system myelination (GO:0022010)3.52127818
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.51504383
35protein localization to synapse (GO:0035418)3.49415821
36regulation of vesicle fusion (GO:0031338)3.48775162
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48275639
38exploration behavior (GO:0035640)3.47733412
39glycine transport (GO:0015816)3.45759917
40regulation of calcium ion-dependent exocytosis (GO:0017158)3.45465122
41presynaptic membrane organization (GO:0097090)3.45448899
42primary amino compound metabolic process (GO:1901160)3.40881612
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40694656
44synaptic transmission, glutamatergic (GO:0035249)3.39565198
45activation of protein kinase A activity (GO:0034199)3.38401716
46positive regulation of membrane potential (GO:0045838)3.36139122
47neuromuscular process controlling posture (GO:0050884)3.32492831
48protein maturation by protein folding (GO:0022417)3.28201109
49peptide hormone processing (GO:0016486)3.28109442
50positive regulation of vesicle fusion (GO:0031340)3.27753356
51innervation (GO:0060384)3.25795275
52proline transport (GO:0015824)3.24745445
53neuron-neuron synaptic transmission (GO:0007270)3.24470397
54auditory behavior (GO:0031223)3.18846452
55long-term memory (GO:0007616)3.18382726
56neurotransmitter transport (GO:0006836)3.15201001
57glutamate receptor signaling pathway (GO:0007215)3.11881351
58cerebellar Purkinje cell layer development (GO:0021680)3.11408062
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11176233
60neuronal action potential (GO:0019228)3.09699120
61cerebellar Purkinje cell differentiation (GO:0021702)3.09555808
62positive regulation of exocytosis (GO:0045921)3.08142486
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06270971
64regulation of insulin secretion (GO:0050796)3.04092504
65neuromuscular synaptic transmission (GO:0007274)3.03500146
66potassium ion import (GO:0010107)3.03422710
67regulation of exocytosis (GO:0017157)3.03222418
68neurotransmitter-gated ion channel clustering (GO:0072578)3.03045938
69regulation of synapse structural plasticity (GO:0051823)3.01134651
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00776596
71regulation of excitatory postsynaptic membrane potential (GO:0060079)2.99915691
72glycosphingolipid biosynthetic process (GO:0006688)2.98208251
73neurotransmitter uptake (GO:0001504)2.97209617
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96992638
75retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96936947
76regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.96216679
77membrane depolarization during action potential (GO:0086010)2.95565711
78membrane depolarization (GO:0051899)2.94833084
79vesicle transport along microtubule (GO:0047496)2.94792000
80protein targeting to Golgi (GO:0000042)2.93187145
81long-term synaptic potentiation (GO:0060291)2.93064367
82gamma-aminobutyric acid transport (GO:0015812)2.92613393
83regulation of neurotransmitter secretion (GO:0046928)2.92459389
84transmission of nerve impulse (GO:0019226)2.92307926
85regulation of synaptic plasticity (GO:0048167)2.91168524
86signal release (GO:0023061)2.90767293
87startle response (GO:0001964)2.89879498
88regulation of respiratory system process (GO:0044065)2.89604881
89dendritic spine morphogenesis (GO:0060997)2.89573602
90regulation of postsynaptic membrane potential (GO:0060078)2.89021390
91membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.88697259
92endocrine pancreas development (GO:0031018)2.88425272
93L-fucose catabolic process (GO:0042355)2.87260630
94fucose catabolic process (GO:0019317)2.87260630
95L-fucose metabolic process (GO:0042354)2.87260630
96potassium ion transmembrane transport (GO:0071805)2.87231971
97cellular potassium ion transport (GO:0071804)2.87231971
98suckling behavior (GO:0001967)2.86993383
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86873217
100detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86551973
101positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.86023399
102positive regulation of insulin secretion (GO:0032024)2.84982496
103regulation of type B pancreatic cell apoptotic process (GO:2000674)2.83512902
104cellular response to glucagon stimulus (GO:0071377)2.83205240
105protein polyglutamylation (GO:0018095)2.83202406
106alanine transport (GO:0032328)2.82151058
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81412769
108synaptic transmission (GO:0007268)2.81163938
109regulation of neurotransmitter levels (GO:0001505)2.81036965
110regulation of beta-amyloid formation (GO:1902003)2.80350101
111synaptic vesicle endocytosis (GO:0048488)2.79993478
112peptide hormone secretion (GO:0030072)2.78127621
113regulation of peptide hormone secretion (GO:0090276)2.77374541
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77003584
115regulation of peptide secretion (GO:0002791)2.76757999
116calcium ion-dependent exocytosis (GO:0017156)2.76216557
117regulation of amyloid precursor protein catabolic process (GO:1902991)2.75405604
118neuron recognition (GO:0008038)2.75131389
119inner ear receptor cell development (GO:0060119)2.74757351
120retinal cone cell development (GO:0046549)2.74661919
121layer formation in cerebral cortex (GO:0021819)2.74037217
122C4-dicarboxylate transport (GO:0015740)2.73659160
123gamma-aminobutyric acid signaling pathway (GO:0007214)2.72897017
124glycerophospholipid catabolic process (GO:0046475)2.72715448
125potassium ion transport (GO:0006813)2.72603528
126cell communication by electrical coupling (GO:0010644)2.72357748
127regulation of synaptic transmission, glutamatergic (GO:0051966)2.71423194
128protein localization to cilium (GO:0061512)2.71405681
129regulation of neurotransmitter transport (GO:0051588)2.71128408
130cellular potassium ion homeostasis (GO:0030007)2.71059356
131action potential (GO:0001508)2.69782130
132peptide secretion (GO:0002790)2.69319724
133regulation of synaptic transmission, GABAergic (GO:0032228)2.68245859
134neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.68071337
135response to pheromone (GO:0019236)2.67959713
136potassium ion homeostasis (GO:0055075)2.67853277
137mechanosensory behavior (GO:0007638)2.67822504
138regulation of ARF protein signal transduction (GO:0032012)2.67692936
139neuronal ion channel clustering (GO:0045161)2.67150983
140positive regulation of potassium ion transport (GO:0043268)2.66311791
141positive regulation of neurotransmitter transport (GO:0051590)2.65616911
142nephron tubule morphogenesis (GO:0072078)2.63593399
143nephron epithelium morphogenesis (GO:0072088)2.63593399
144negative regulation of neurotransmitter transport (GO:0051589)2.63400174
145reflex (GO:0060004)2.61101089
146cyclic nucleotide catabolic process (GO:0009214)2.59574396
147adult walking behavior (GO:0007628)2.58573291
148water-soluble vitamin biosynthetic process (GO:0042364)2.56832547
149regulation of action potential (GO:0098900)2.56505015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.79263102
2GBX2_23144817_ChIP-Seq_PC3_Human3.65114164
3* REST_21632747_ChIP-Seq_MESCs_Mouse2.90980555
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87620049
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67251664
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65421242
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59469360
8* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42330506
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35927240
10* REST_18959480_ChIP-ChIP_MESCs_Mouse2.35898328
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33348782
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.31541809
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29608838
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27029408
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.25946167
16DROSHA_22980978_ChIP-Seq_HELA_Human2.23097857
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17578862
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17578862
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15451080
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.04446566
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03406672
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02993300
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95988589
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.94601216
25IGF1R_20145208_ChIP-Seq_DFB_Human1.90619994
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.89400653
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89056210
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.86825381
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82628045
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.81514598
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.80422316
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73707180
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73296408
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73100278
35ZNF274_21170338_ChIP-Seq_K562_Hela1.65995118
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64007489
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63175834
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61631827
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59104600
40* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58241890
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.51622823
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50891344
43* STAT3_23295773_ChIP-Seq_U87_Human1.48866282
44ER_23166858_ChIP-Seq_MCF-7_Human1.48344643
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47200218
46* P300_19829295_ChIP-Seq_ESCs_Human1.45271779
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44455136
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.41802517
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40442097
50TAF15_26573619_Chip-Seq_HEK293_Human1.39603032
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39483112
52EWS_26573619_Chip-Seq_HEK293_Human1.34956620
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33779755
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30819575
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30197852
56CBP_20019798_ChIP-Seq_JUKART_Human1.30197852
57AR_25329375_ChIP-Seq_VCAP_Human1.29486441
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.29071134
59AR_21572438_ChIP-Seq_LNCaP_Human1.27244999
60* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26989466
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26458397
62* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26405922
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25642570
64TCF4_23295773_ChIP-Seq_U87_Human1.23643169
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22952883
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21864376
67* AR_19668381_ChIP-Seq_PC3_Human1.21435102
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21308987
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21308987
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21240604
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20699099
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18847390
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17515391
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.15694165
75VDR_22108803_ChIP-Seq_LS180_Human1.15502895
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14514608
77TP53_22573176_ChIP-Seq_HFKS_Human1.14419404
78TCF4_22108803_ChIP-Seq_LS180_Human1.13876220
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12692919
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12175584
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.12013697
82RUNX2_22187159_ChIP-Seq_PCA_Human1.11012958
83RNF2_27304074_Chip-Seq_NSC_Mouse1.09402110
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.07341510
85* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06908869
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.06793077
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06657051
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.06525572
89SOX2_19829295_ChIP-Seq_ESCs_Human1.04905062
90NANOG_19829295_ChIP-Seq_ESCs_Human1.04905062
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04773051
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04244840
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03970749
94* NANOG_18555785_Chip-Seq_ESCs_Mouse1.03679178
95* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02982376
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.02852658
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.02654250
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02358758
99FUS_26573619_Chip-Seq_HEK293_Human1.02214697
100JUN_21703547_ChIP-Seq_K562_Human1.00927969
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00199399
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.00097577
103BCAT_22108803_ChIP-Seq_LS180_Human0.99234544
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99130297
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98919337
106* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96879987
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95805038
108RING1B_27294783_Chip-Seq_ESCs_Mouse0.95741579
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95558857
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95012665
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.94215580
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93925879
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93870821
114OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93491004
115FLI1_21867929_ChIP-Seq_TH2_Mouse0.92614231
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.92347408
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92021869
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.90784994
119AHR_22903824_ChIP-Seq_MCF-7_Human0.89386707
120* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87551049
121P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87426167
122* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85081962
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85048542
124* P53_22387025_ChIP-Seq_ESCs_Mouse0.84436539
125E2F1_18555785_Chip-Seq_ESCs_Mouse0.82206072

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.67763757
2MP0004270_analgesia3.50954173
3MP0003635_abnormal_synaptic_transmissio3.29245733
4MP0002909_abnormal_adrenal_gland3.25627940
5MP0003880_abnormal_central_pattern3.18294939
6MP0009780_abnormal_chondrocyte_physiolo2.89097582
7MP0000013_abnormal_adipose_tissue2.81991695
8MP0009745_abnormal_behavioral_response2.67907844
9MP0010386_abnormal_urinary_bladder2.67020511
10MP0002822_catalepsy2.60188308
11MP0002063_abnormal_learning/memory/cond2.58974691
12MP0003283_abnormal_digestive_organ2.52390606
13MP0002064_seizures2.48801826
14MP0002734_abnormal_mechanical_nocicepti2.47910688
15MP0005645_abnormal_hypothalamus_physiol2.47590307
16MP0002572_abnormal_emotion/affect_behav2.40683790
17MP0005646_abnormal_pituitary_gland2.36487384
18MP0003183_abnormal_peptide_metabolism2.31029182
19MP0002272_abnormal_nervous_system2.31021421
20MP0008877_abnormal_DNA_methylation2.30791686
21MP0009046_muscle_twitch2.26370180
22MP0001968_abnormal_touch/_nociception2.21269314
23MP0002735_abnormal_chemical_nociception2.17367165
24MP0003122_maternal_imprinting2.16113135
25MP0004043_abnormal_pH_regulation2.13918407
26MP0001501_abnormal_sleep_pattern2.12297394
27MP0005379_endocrine/exocrine_gland_phen2.07112071
28MP0002733_abnormal_thermal_nociception2.05582292
29MP0002693_abnormal_pancreas_physiology2.02989693
30MP0002877_abnormal_melanocyte_morpholog1.95455955
31MP0003787_abnormal_imprinting1.92810874
32MP0001970_abnormal_pain_threshold1.88390248
33MP0002638_abnormal_pupillary_reflex1.82845683
34MP0001486_abnormal_startle_reflex1.82780093
35MP0006276_abnormal_autonomic_nervous1.75964627
36MP0001944_abnormal_pancreas_morphology1.74341723
37MP0005423_abnormal_somatic_nervous1.73330990
38MP0001440_abnormal_grooming_behavior1.64056490
39MP0002837_dystrophic_cardiac_calcinosis1.62952886
40MP0004147_increased_porphyrin_level1.61036826
41MP0002067_abnormal_sensory_capabilities1.60514900
42MP0002184_abnormal_innervation1.59072390
43MP0002736_abnormal_nociception_after1.57984784
44MP0002557_abnormal_social/conspecific_i1.56087071
45MP0008569_lethality_at_weaning1.52092648
46MP0001986_abnormal_taste_sensitivity1.51231229
47MP0000678_abnormal_parathyroid_gland1.49933096
48MP0003195_calcinosis1.48571108
49MP0001502_abnormal_circadian_rhythm1.47027800
50MP0003879_abnormal_hair_cell1.46759643
51MP0005386_behavior/neurological_phenoty1.43394546
52MP0004924_abnormal_behavior1.43394546
53MP0008872_abnormal_physiological_respon1.42376663
54MP0000955_abnormal_spinal_cord1.40131064
55MP0004811_abnormal_neuron_physiology1.39773003
56MP0001984_abnormal_olfaction1.36052925
57MP0001188_hyperpigmentation1.34408251
58MP0008961_abnormal_basal_metabolism1.34143139
59MP0001529_abnormal_vocalization1.33056591
60MP0003172_abnormal_lysosome_physiology1.30308216
61MP0006072_abnormal_retinal_apoptosis1.28336363
62MP0004858_abnormal_nervous_system1.27898103
63MP0001485_abnormal_pinna_reflex1.21793050
64MP0003329_amyloid_beta_deposits1.21124832
65MP0002078_abnormal_glucose_homeostasis1.20602728
66MP0004742_abnormal_vestibular_system1.18975176
67MP0002102_abnormal_ear_morphology1.18822229
68MP0000003_abnormal_adipose_tissue1.17108122
69MP0003633_abnormal_nervous_system1.14827956
70MP0004133_heterotaxia1.14612587
71MP0002876_abnormal_thyroid_physiology1.14206106
72MP0002066_abnormal_motor_capabilities/c1.14061478
73MP0002882_abnormal_neuron_morphology1.12939021
74MP0005535_abnormal_body_temperature1.12518292
75MP0000778_abnormal_nervous_system1.05525384
76MP0000631_abnormal_neuroendocrine_gland1.04260807
77MP0000427_abnormal_hair_cycle1.04016928
78MP0005167_abnormal_blood-brain_barrier1.00326270
79MP0004145_abnormal_muscle_electrophysio1.00262805
80MP0002069_abnormal_eating/drinking_beha0.98623872
81MP0001905_abnormal_dopamine_level0.98229711
82MP0002229_neurodegeneration0.96357160
83MP0001765_abnormal_ion_homeostasis0.96018993
84MP0004885_abnormal_endolymph0.94398954
85MP0002234_abnormal_pharynx_morphology0.93193381
86MP0004142_abnormal_muscle_tone0.92867323
87MP0003953_abnormal_hormone_level0.92143290
88MP0003646_muscle_fatigue0.86473548
89MP0004085_abnormal_heartbeat0.85008976
90MP0003631_nervous_system_phenotype0.84653428
91MP0002163_abnormal_gland_morphology0.84352189
92MP0006292_abnormal_olfactory_placode0.81994587
93MP0002752_abnormal_somatic_nervous0.79254258
94MP0005551_abnormal_eye_electrophysiolog0.78768536
95MP0004215_abnormal_myocardial_fiber0.78629107
96MP0003632_abnormal_nervous_system0.78427588
97MP0005174_abnormal_tail_pigmentation0.77620701
98MP0003045_fibrosis0.76809865
99MP0003123_paternal_imprinting0.76172969
100MP0010329_abnormal_lipoprotein_level0.75404314
101MP0003121_genomic_imprinting0.75071476
102MP0000920_abnormal_myelination0.75051042
103MP0001299_abnormal_eye_distance/0.74862771
104MP0002152_abnormal_brain_morphology0.74774541
105MP0005084_abnormal_gallbladder_morpholo0.74252904
106MP0003690_abnormal_glial_cell0.73595296
107MP0003137_abnormal_impulse_conducting0.71226767
108MP0008875_abnormal_xenobiotic_pharmacok0.70255529
109MP0002751_abnormal_autonomic_nervous0.69973020
110MP0003634_abnormal_glial_cell0.69506705
111MP0001664_abnormal_digestion0.69405305
112MP0005220_abnormal_exocrine_pancreas0.68082621
113MP0000230_abnormal_systemic_arterial0.67716234
114MP0000015_abnormal_ear_pigmentation0.64577986
115MP0005253_abnormal_eye_physiology0.62673325
116MP0001963_abnormal_hearing_physiology0.61683591
117MP0005448_abnormal_energy_balance0.61353587
118MP0002090_abnormal_vision0.58907647
119MP0005394_taste/olfaction_phenotype0.58895190
120MP0005499_abnormal_olfactory_system0.58895190
121MP0000538_abnormal_urinary_bladder0.58037960
122MP0000569_abnormal_digit_pigmentation0.58036267

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.88324264
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.52233129
3Hyperinsulinemic hypoglycemia (HP:0000825)4.72630329
4Visual hallucinations (HP:0002367)4.70512305
5Myokymia (HP:0002411)4.43023007
6Hypoglycemic seizures (HP:0002173)4.22336043
7Focal seizures (HP:0007359)4.12058221
8Atonic seizures (HP:0010819)3.98120325
9Symptomatic seizures (HP:0011145)3.89674272
10Abnormality of calcium-phosphate metabolism (HP:0100530)3.83030711
11Epileptic encephalopathy (HP:0200134)3.68530573
12Papilledema (HP:0001085)3.66402509
13Febrile seizures (HP:0002373)3.63515848
14Agitation (HP:0000713)3.60927475
15Absence seizures (HP:0002121)3.49694747
16Congenital stationary night blindness (HP:0007642)3.40897307
17Decreased circulating renin level (HP:0003351)3.27166309
18Epileptiform EEG discharges (HP:0011182)3.25633455
19Progressive cerebellar ataxia (HP:0002073)3.24501279
20EEG with generalized epileptiform discharges (HP:0011198)3.20900210
21Generalized tonic-clonic seizures (HP:0002069)3.20845242
22Insulin-resistant diabetes mellitus (HP:0000831)3.18207096
23Dialeptic seizures (HP:0011146)3.18197718
24Pheochromocytoma (HP:0002666)3.11474000
25Hypsarrhythmia (HP:0002521)3.09574215
26Nephronophthisis (HP:0000090)3.05069828
27Pancreatic cysts (HP:0001737)3.03726193
28Action tremor (HP:0002345)3.02539287
29Hypothermia (HP:0002045)2.99237293
30Anxiety (HP:0000739)2.92532035
31Pancreatic fibrosis (HP:0100732)2.87013980
32Hyperglycemia (HP:0003074)2.84555338
33Medial flaring of the eyebrow (HP:0010747)2.83837803
34Depression (HP:0000716)2.82876687
35Abnormality of midbrain morphology (HP:0002418)2.82080477
36Molar tooth sign on MRI (HP:0002419)2.82080477
37Pancreatic islet-cell hyperplasia (HP:0004510)2.81966671
38Supranuclear gaze palsy (HP:0000605)2.81602406
39Abnormal drinking behavior (HP:0030082)2.76112148
40Polydipsia (HP:0001959)2.76112148
41Large for gestational age (HP:0001520)2.75294487
42Neuroendocrine neoplasm (HP:0100634)2.74769136
43True hermaphroditism (HP:0010459)2.67354437
44Abnormality of the renal cortex (HP:0011035)2.66104492
45Inability to walk (HP:0002540)2.62837858
46Polyphagia (HP:0002591)2.62366960
47Truncal ataxia (HP:0002078)2.61028158
48Abnormality of the renal medulla (HP:0100957)2.61021313
49Abnormality of the pancreatic islet cells (HP:0006476)2.60821873
50Abnormality of endocrine pancreas physiology (HP:0012093)2.60821873
51Menstrual irregularities (HP:0000858)2.57877488
52Hypoglycemic coma (HP:0001325)2.54738342
53Impaired smooth pursuit (HP:0007772)2.51819133
54Abnormality of binocular vision (HP:0011514)2.51533143
55Diplopia (HP:0000651)2.51533143
56Ketoacidosis (HP:0001993)2.51153778
57Increased circulating renin level (HP:0000848)2.48438750
58Progressive inability to walk (HP:0002505)2.39575821
59Hyperparathyroidism (HP:0000843)2.36365828
60Intestinal atresia (HP:0011100)2.34859223
61Ankle clonus (HP:0011448)2.33775467
62Amblyopia (HP:0000646)2.32307896
63Failure to thrive in infancy (HP:0001531)2.30319723
64Congenital primary aphakia (HP:0007707)2.29933425
65Dysautonomia (HP:0002459)2.24192228
66Abnormality of renin-angiotensin system (HP:0000847)2.22399916
67Poor eye contact (HP:0000817)2.20382571
68Gaze-evoked nystagmus (HP:0000640)2.19926194
69Hemiparesis (HP:0001269)2.19148943
70Lissencephaly (HP:0001339)2.18899654
71Hypercortisolism (HP:0001578)2.18291325
72Attenuation of retinal blood vessels (HP:0007843)2.17738549
73Methylmalonic acidemia (HP:0002912)2.17061285
74Status epilepticus (HP:0002133)2.15946567
75Excessive salivation (HP:0003781)2.15321302
76Drooling (HP:0002307)2.15321302
77Hyperventilation (HP:0002883)2.15153696
78Hypokalemia (HP:0002900)2.14336586
79Blue irides (HP:0000635)2.13536822
80Hemiplegia (HP:0002301)2.11750843
81Cortical visual impairment (HP:0100704)2.09724553
82Nephrogenic diabetes insipidus (HP:0009806)2.09478913
83Abnormal pancreas size (HP:0012094)2.09157711
84Hyperkalemia (HP:0002153)2.07681267
85Dysmetria (HP:0001310)2.06968908
86Dysdiadochokinesis (HP:0002075)2.06536571
87Urinary glycosaminoglycan excretion (HP:0003541)2.05724995
88Mucopolysacchariduria (HP:0008155)2.05724995
89Broad-based gait (HP:0002136)2.05709786
90Polyuria (HP:0000103)2.04282766
91Impaired vibration sensation in the lower limbs (HP:0002166)2.04062457
92Renal cortical cysts (HP:0000803)2.03261074
93Impaired social interactions (HP:0000735)2.02971720
94Abnormal social behavior (HP:0012433)2.02971720
95Dysostosis multiplex (HP:0000943)2.02486041
96Postural instability (HP:0002172)2.01204180
97Type II lissencephaly (HP:0007260)1.99987335
98Restlessness (HP:0000711)1.99932043
99Postural tremor (HP:0002174)1.99861208
100Torticollis (HP:0000473)1.99503987
101Ventricular fibrillation (HP:0001663)1.99001328
102Genital tract atresia (HP:0001827)1.98912495
103Abnormality of the corticospinal tract (HP:0002492)1.98563620
104Abnormality of potassium homeostasis (HP:0011042)1.98453570
105Cystic liver disease (HP:0006706)1.98377678
106Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98114394
107Abnormality of polysaccharide metabolism (HP:0011012)1.98114394
108Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98114394
109Abnormality of ocular smooth pursuit (HP:0000617)1.97910211
110Late onset (HP:0003584)1.96837091
111Abnormal eating behavior (HP:0100738)1.94653515
112Degeneration of the lateral corticospinal tracts (HP:0002314)1.94596708
113Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94596708
114Chronic hepatic failure (HP:0100626)1.93377167
115Abolished electroretinogram (ERG) (HP:0000550)1.92553398
116Cerebellar dysplasia (HP:0007033)1.91868937
117Vaginal atresia (HP:0000148)1.90898531
118Hyperphosphatemia (HP:0002905)1.89448876
119Abnormality of vitamin B metabolism (HP:0004340)1.88688835
120Gait imbalance (HP:0002141)1.87969809
121Bradykinesia (HP:0002067)1.87609565
122Retinal dysplasia (HP:0007973)1.87388389
123Urinary bladder sphincter dysfunction (HP:0002839)1.86867217
124Tubular atrophy (HP:0000092)1.86138464
125Neurofibrillary tangles (HP:0002185)1.86098897
126Absent speech (HP:0001344)1.85504253
127Abnormal rod and cone electroretinograms (HP:0008323)1.83458114
128Genetic anticipation (HP:0003743)1.82661267
129Osteomalacia (HP:0002749)1.82268587
130Spastic gait (HP:0002064)1.82041408
131Psychosis (HP:0000709)1.81761851
132Limb dystonia (HP:0002451)1.81578573
133Adrenal overactivity (HP:0002717)1.81039007
134Fair hair (HP:0002286)1.81006095
135Prolonged QT interval (HP:0001657)1.78301212
136Widely spaced teeth (HP:0000687)1.78106360
137Muscular hypotonia of the trunk (HP:0008936)1.77674798
138Abnormal EKG (HP:0003115)1.77581971
139Specific learning disability (HP:0001328)1.77376637
140Cerebral inclusion bodies (HP:0100314)1.77120058
141Macroorchidism (HP:0000053)1.76609654
142Focal dystonia (HP:0004373)1.76493458
143Methylmalonic aciduria (HP:0012120)1.75385221
144Abnormality of macular pigmentation (HP:0008002)1.75253600
145Abnormality of the labia minora (HP:0012880)1.74789491
146Hyperactive renin-angiotensin system (HP:0000841)1.74232771
147Protruding tongue (HP:0010808)1.73407377
148Hypotension (HP:0002615)1.73142805
149Pachygyria (HP:0001302)1.73138169
150Clumsiness (HP:0002312)1.72038361
151Decreased central vision (HP:0007663)1.71912655
152Generalized hypopigmentation of hair (HP:0011358)1.70891725
153Sleep apnea (HP:0010535)1.70166210
154Keratoconus (HP:0000563)1.69961905
155Increased corneal curvature (HP:0100692)1.69961905

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.32673945
2INSRR3.63167928
3PRKD33.04936683
4EPHA42.84066858
5MAP3K92.68245772
6NTRK12.59514229
7MAP3K42.56341924
8MAPK152.49490338
9MAP4K22.41637154
10MAP2K72.36130240
11MAP3K22.26807315
12WNK32.12773037
13ADRBK22.09958036
14MINK12.03883462
15MARK11.97919099
16TAOK31.97064722
17GRK11.94898776
18UHMK11.86819332
19PASK1.78594511
20CAMKK21.73120345
21KSR21.72097721
22OXSR11.70104215
23HIPK21.64159761
24NTRK21.55426478
25RIPK41.52715290
26TNIK1.50036119
27DAPK21.48282517
28CASK1.44638791
29BMPR1B1.44622643
30CAMKK11.44258191
31MAP3K11.41378818
32PAK61.41256216
33PNCK1.40331486
34MAP2K41.40306765
35WNK41.39349087
36MAP2K61.38632077
37GRK51.38620804
38MAP3K121.31777257
39CDK51.31472098
40FGFR21.30519148
41STK391.27631631
42ACVR1B1.22871017
43PRKCH1.21984428
44CDC42BPA1.21503757
45ARAF1.16931077
46MAPK131.14290193
47AKT31.12763041
48PRKCG1.10563108
49BMPR21.09224774
50MAPKAPK51.09199038
51SCYL21.09143568
52DAPK11.06652815
53FRK1.06263495
54WNK11.04686792
55SGK4941.03152488
56SGK2231.03152488
57SGK21.01136700
58ZAK0.97065359
59PAK30.94929239
60CAMK2B0.94515001
61CAMK2A0.92059963
62MKNK20.91590453
63STK380.90364209
64FES0.89337563
65CSNK1G30.87067712
66KSR10.86902609
67PRKCE0.86811054
68RET0.82754427
69NEK60.82384021
70CAMK2D0.79758325
71FER0.79499541
72MAPKAPK30.79355004
73PLK20.77250894
74CSNK1G10.75639297
75TLK10.74605070
76PRPF4B0.73923989
77NUAK10.72417006
78SGK30.68810530
79PTK2B0.68541001
80CSNK1A1L0.67943492
81DYRK20.67694960
82STK38L0.67175468
83CAMK10.67034206
84BRAF0.65984968
85SGK10.65769648
86MARK20.63245787
87DYRK1A0.61619788
88MAP3K130.61280561
89PKN10.60259999
90TRIM280.60183490
91PRKD20.60017569
92PINK10.59231100
93PRKCZ0.56008009
94GRK70.55782033
95CSNK1D0.53741668
96BRSK10.52898993
97TNK20.51731666
98PDGFRA0.51557004
99CCNB10.48716276
100MAP2K10.48590516
101RPS6KA20.48344568
102CSNK1G20.48309752
103PRKG10.48150260
104TRPM70.47630067
105CAMK40.47360795
106RPS6KA30.47191427
107PRKAA10.46925843
108IRAK10.46884667
109ALK0.44449467
110CDK140.44130018
111PTK20.44120347
112PHKG10.43909237
113PHKG20.43909237
114MAPK100.43265428
115PRKACA0.41976468
116CAMK1G0.41789948
117STK110.41603164
118CAMK2G0.40762460
119SIK20.40312674
120CDK180.39988294
121CSNK1A10.39636386
122TIE10.39556957
123TXK0.39194169
124PDPK10.38903935
125IRAK20.38618151
126CAMK1D0.38376866
127PDK10.37753543
128PIK3CA0.37508715
129CDK150.37386623
130ERBB30.35968192
131EPHA30.35863464
132CDK190.35584353
133PRKCQ0.35394447
134PRKCA0.35031586
135PRKACB0.34940006
136BCR0.34278160
137PRKCB0.33945461
138MAPK120.33436456
139ADRBK10.33171332

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.84797791
2Insulin secretion_Homo sapiens_hsa049113.19163570
3Synaptic vesicle cycle_Homo sapiens_hsa047212.95688087
4Nicotine addiction_Homo sapiens_hsa050332.86648407
5Amphetamine addiction_Homo sapiens_hsa050312.57048549
6GABAergic synapse_Homo sapiens_hsa047272.51720489
7Circadian entrainment_Homo sapiens_hsa047132.46063527
8Long-term potentiation_Homo sapiens_hsa047202.39771469
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31121021
10Morphine addiction_Homo sapiens_hsa050322.17429339
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17304851
12Glutamatergic synapse_Homo sapiens_hsa047242.12091479
13Dopaminergic synapse_Homo sapiens_hsa047282.11711491
14Taste transduction_Homo sapiens_hsa047422.11436277
15Cocaine addiction_Homo sapiens_hsa050302.10670215
16Olfactory transduction_Homo sapiens_hsa047402.08289140
17Type II diabetes mellitus_Homo sapiens_hsa049302.05191449
18Cholinergic synapse_Homo sapiens_hsa047251.87272459
19Type I diabetes mellitus_Homo sapiens_hsa049401.85362751
20Serotonergic synapse_Homo sapiens_hsa047261.82466416
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80731781
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76575176
23Vibrio cholerae infection_Homo sapiens_hsa051101.75352297
24Salivary secretion_Homo sapiens_hsa049701.67077211
25Collecting duct acid secretion_Homo sapiens_hsa049661.65543407
26Vitamin B6 metabolism_Homo sapiens_hsa007501.62487608
27Protein export_Homo sapiens_hsa030601.61965076
28Butanoate metabolism_Homo sapiens_hsa006501.55059535
29Nitrogen metabolism_Homo sapiens_hsa009101.51127688
30Long-term depression_Homo sapiens_hsa047301.50469111
31Renin secretion_Homo sapiens_hsa049241.50315388
32Gastric acid secretion_Homo sapiens_hsa049711.48971332
33Ether lipid metabolism_Homo sapiens_hsa005651.34606038
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33917683
35Calcium signaling pathway_Homo sapiens_hsa040201.28901995
36Linoleic acid metabolism_Homo sapiens_hsa005911.27170305
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26841112
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26452480
39Pancreatic secretion_Homo sapiens_hsa049721.26238668
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24455973
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24101820
42Oxytocin signaling pathway_Homo sapiens_hsa049211.21836159
43GnRH signaling pathway_Homo sapiens_hsa049121.18650655
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16525880
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14845477
46Selenocompound metabolism_Homo sapiens_hsa004501.14640425
47cAMP signaling pathway_Homo sapiens_hsa040241.14278206
48Estrogen signaling pathway_Homo sapiens_hsa049151.13468802
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07845533
50Thyroid hormone synthesis_Homo sapiens_hsa049181.07243633
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06534651
52Gap junction_Homo sapiens_hsa045401.04866823
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02938380
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00999132
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00442872
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.98168132
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91149510
58Circadian rhythm_Homo sapiens_hsa047100.91133818
59ABC transporters_Homo sapiens_hsa020100.90802840
60Sulfur metabolism_Homo sapiens_hsa009200.89303145
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88146343
62Glucagon signaling pathway_Homo sapiens_hsa049220.87467944
63Melanogenesis_Homo sapiens_hsa049160.84655667
64Dorso-ventral axis formation_Homo sapiens_hsa043200.81873893
65Tryptophan metabolism_Homo sapiens_hsa003800.81465119
66Parkinsons disease_Homo sapiens_hsa050120.78088225
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76445321
68Glioma_Homo sapiens_hsa052140.74986221
69Propanoate metabolism_Homo sapiens_hsa006400.73202248
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72801752
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71667290
72beta-Alanine metabolism_Homo sapiens_hsa004100.68850597
73Mineral absorption_Homo sapiens_hsa049780.67656197
74ErbB signaling pathway_Homo sapiens_hsa040120.67482020
75Prion diseases_Homo sapiens_hsa050200.65803405
76N-Glycan biosynthesis_Homo sapiens_hsa005100.64887604
77Caffeine metabolism_Homo sapiens_hsa002320.63618317
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61923287
79Alcoholism_Homo sapiens_hsa050340.61488928
80Inositol phosphate metabolism_Homo sapiens_hsa005620.61429084
81Cardiac muscle contraction_Homo sapiens_hsa042600.60687014
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60371494
83Lysosome_Homo sapiens_hsa041420.60127216
84Peroxisome_Homo sapiens_hsa041460.59699918
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59491121
86Phototransduction_Homo sapiens_hsa047440.59182011
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.58351288
88Regulation of autophagy_Homo sapiens_hsa041400.56945349
89Oocyte meiosis_Homo sapiens_hsa041140.55896566
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.54186435
91MAPK signaling pathway_Homo sapiens_hsa040100.51999456
92Bile secretion_Homo sapiens_hsa049760.51633087
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51514353
94Axon guidance_Homo sapiens_hsa043600.51404742
95Histidine metabolism_Homo sapiens_hsa003400.50917222
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.49947961
97Prolactin signaling pathway_Homo sapiens_hsa049170.49866740
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47735895
99Alzheimers disease_Homo sapiens_hsa050100.47256894
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46861458
101Choline metabolism in cancer_Homo sapiens_hsa052310.46737852
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46257546
103Ovarian steroidogenesis_Homo sapiens_hsa049130.46057944
104Dilated cardiomyopathy_Homo sapiens_hsa054140.44168720
105Insulin signaling pathway_Homo sapiens_hsa049100.42973749
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.42132443
107Ras signaling pathway_Homo sapiens_hsa040140.40830804
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40579137
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39873549
110mTOR signaling pathway_Homo sapiens_hsa041500.38963360
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37852673
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.36880941
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36058167
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36027748
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35879199
116Basal transcription factors_Homo sapiens_hsa030220.35667807
117Glycerolipid metabolism_Homo sapiens_hsa005610.35662532
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35325681
119Folate biosynthesis_Homo sapiens_hsa007900.34731747
120Arachidonic acid metabolism_Homo sapiens_hsa005900.30956449
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30644496
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.30283771
123Wnt signaling pathway_Homo sapiens_hsa043100.30089008
124Huntingtons disease_Homo sapiens_hsa050160.29495754
125Endocytosis_Homo sapiens_hsa041440.29394095
126Rheumatoid arthritis_Homo sapiens_hsa053230.29376332
127Chemical carcinogenesis_Homo sapiens_hsa052040.28945961
128Insulin resistance_Homo sapiens_hsa049310.27858149
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26247344
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26084157
131Oxidative phosphorylation_Homo sapiens_hsa001900.26008678
132VEGF signaling pathway_Homo sapiens_hsa043700.24712676
133Sphingolipid metabolism_Homo sapiens_hsa006000.24030745
134Endometrial cancer_Homo sapiens_hsa052130.23840200

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