SLC7A13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.64937250
2urate metabolic process (GO:0046415)9.46263465
3aminoglycoside antibiotic metabolic process (GO:0030647)9.07347714
4drug transport (GO:0015893)7.75697793
5organic cation transport (GO:0015695)7.08278349
6exogenous drug catabolic process (GO:0042738)7.03180069
7phosphate ion transport (GO:0006817)6.73721671
8drug catabolic process (GO:0042737)6.68590170
9glyoxylate metabolic process (GO:0046487)5.77103851
10quaternary ammonium group transport (GO:0015697)5.66624008
11nonribosomal peptide biosynthetic process (GO:0019184)5.61349706
12phosphate ion transmembrane transport (GO:0035435)5.58164839
13behavioral response to nicotine (GO:0035095)5.41944638
14response to pheromone (GO:0019236)5.35541469
15lysine catabolic process (GO:0006554)5.31706272
16lysine metabolic process (GO:0006553)5.31706272
17glutathione biosynthetic process (GO:0006750)5.04817444
18axon ensheathment in central nervous system (GO:0032291)4.88945292
19central nervous system myelination (GO:0022010)4.88945292
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.87852987
21L-phenylalanine catabolic process (GO:0006559)4.87852987
22cysteine metabolic process (GO:0006534)4.85886855
23response to mercury ion (GO:0046689)4.85285272
24metanephric tubule development (GO:0072170)4.80347784
25metanephric nephron tubule development (GO:0072234)4.80347784
26short-chain fatty acid metabolic process (GO:0046459)4.79074675
27excretion (GO:0007588)4.77169290
28phosphate ion homeostasis (GO:0055062)4.57975763
29trivalent inorganic anion homeostasis (GO:0072506)4.57975763
30L-phenylalanine metabolic process (GO:0006558)4.55268298
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.55268298
32toxin transport (GO:1901998)4.48458516
33behavioral response to ethanol (GO:0048149)4.40581716
34metanephric nephron epithelium development (GO:0072243)4.38786833
35branched-chain amino acid metabolic process (GO:0009081)4.34593439
36sodium-independent organic anion transport (GO:0043252)4.33404037
37peptide biosynthetic process (GO:0043043)4.32069993
38aspartate family amino acid catabolic process (GO:0009068)4.26213151
39renal absorption (GO:0070293)4.20689342
40vitamin D metabolic process (GO:0042359)4.13806366
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.07608488
42water-soluble vitamin biosynthetic process (GO:0042364)4.07400294
43metanephric epithelium development (GO:0072207)4.07320736
44negative regulation of cytosolic calcium ion concentration (GO:0051481)4.05309488
45aromatic amino acid family catabolic process (GO:0009074)4.00910787
46opioid receptor signaling pathway (GO:0038003)3.94109507
47hindbrain development (GO:0030902)3.91323133
48nephron tubule development (GO:0072080)3.88018924
49tricarboxylic acid metabolic process (GO:0072350)3.87427751
50oligosaccharide catabolic process (GO:0009313)3.85119247
51glycoside metabolic process (GO:0016137)3.81758266
52cilium or flagellum-dependent cell motility (GO:0001539)3.77516984
53branched-chain amino acid catabolic process (GO:0009083)3.73887219
54L-fucose catabolic process (GO:0042355)3.73782634
55fucose catabolic process (GO:0019317)3.73782634
56L-fucose metabolic process (GO:0042354)3.73782634
57response to lead ion (GO:0010288)3.73130803
58carnitine transport (GO:0015879)3.70488729
59amino-acid betaine transport (GO:0015838)3.70488729
60cellular modified amino acid catabolic process (GO:0042219)3.66419590
61response to phenylpropanoid (GO:0080184)3.63572546
62epithelial cilium movement (GO:0003351)3.59062324
63polyol transport (GO:0015791)3.57423921
64proline metabolic process (GO:0006560)3.55314903
65piRNA metabolic process (GO:0034587)3.54824915
66serine family amino acid metabolic process (GO:0009069)3.49292870
67DNA deamination (GO:0045006)3.47326736
68glutathione metabolic process (GO:0006749)3.45102714
69neuronal action potential (GO:0019228)3.44739951
70fatty acid beta-oxidation (GO:0006635)3.41479768
71neural tube formation (GO:0001841)3.40952169
72renal tubule development (GO:0061326)3.40831466
73glutathione derivative metabolic process (GO:1901685)3.40648251
74glutathione derivative biosynthetic process (GO:1901687)3.40648251
75adult feeding behavior (GO:0008343)3.40343504
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39174818
77mitochondrial respiratory chain complex I assembly (GO:0032981)3.39174818
78NADH dehydrogenase complex assembly (GO:0010257)3.39174818
79modified amino acid transport (GO:0072337)3.37863675
80positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.37017285
81acetyl-CoA metabolic process (GO:0006084)3.33907644
82nephron epithelium development (GO:0072009)3.33523387
83cellular ketone body metabolic process (GO:0046950)3.33435973
84tryptophan catabolic process (GO:0006569)3.31121151
85indole-containing compound catabolic process (GO:0042436)3.31121151
86indolalkylamine catabolic process (GO:0046218)3.31121151
87serine family amino acid catabolic process (GO:0009071)3.30586575
88negative regulation of telomere maintenance (GO:0032205)3.29531938
89cornea development in camera-type eye (GO:0061303)3.25145625
90homocysteine metabolic process (GO:0050667)3.24486462
91protein complex biogenesis (GO:0070271)3.23916283
92cellular response to ATP (GO:0071318)3.18093838
93cilium morphogenesis (GO:0060271)3.14211207
94tryptophan metabolic process (GO:0006568)3.14147281
95fatty acid oxidation (GO:0019395)3.11034908
96amino-acid betaine metabolic process (GO:0006577)3.09887718
97regulation of action potential (GO:0098900)3.09829207
98dopamine biosynthetic process (GO:0042416)3.08434618
99lipid oxidation (GO:0034440)3.06032080
100negative regulation of DNA-dependent DNA replication (GO:2000104)3.05531172
101somite development (GO:0061053)3.05118131
102drug metabolic process (GO:0017144)3.03982420
103resolution of meiotic recombination intermediates (GO:0000712)3.03783702
104mitochondrial respiratory chain complex assembly (GO:0033108)3.03034217
105epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02327914
106rRNA catabolic process (GO:0016075)3.02025520
107positive regulation of cellular amine metabolic process (GO:0033240)2.99239081
108gamma-aminobutyric acid transport (GO:0015812)2.97755435
109myelin maintenance (GO:0043217)2.97449921
110valine metabolic process (GO:0006573)2.97361205
111phosphatidylinositol acyl-chain remodeling (GO:0036149)2.96649971
112replication fork processing (GO:0031297)2.96285691
113detection of light stimulus involved in sensory perception (GO:0050962)2.95977451
114detection of light stimulus involved in visual perception (GO:0050908)2.95977451
115neurotransmitter biosynthetic process (GO:0042136)2.94847993
116cellular amino acid catabolic process (GO:0009063)2.94138562
117serine family amino acid biosynthetic process (GO:0009070)2.93798036
118fructose metabolic process (GO:0006000)2.92766261
119regulation of telomere maintenance (GO:0032204)2.92678314
120positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.92588972
121protein prenylation (GO:0018342)2.92516705
122prenylation (GO:0097354)2.92516705
123fatty acid catabolic process (GO:0009062)2.89913419
124aldehyde catabolic process (GO:0046185)2.89846616
125ketone body metabolic process (GO:1902224)2.88694126
126sodium ion transport (GO:0006814)2.85759298
127aromatic amino acid family metabolic process (GO:0009072)2.85712886
128platelet dense granule organization (GO:0060155)2.84923088
129regulation of rhodopsin mediated signaling pathway (GO:0022400)2.84545256
130cilium movement (GO:0003341)2.83778789
131polyol catabolic process (GO:0046174)2.81141743
132carnitine metabolic process (GO:0009437)2.81035437
133alpha-amino acid catabolic process (GO:1901606)2.79794450
134L-amino acid import (GO:0043092)2.79346780
135nephron tubule morphogenesis (GO:0072078)2.78879795
136nephron epithelium morphogenesis (GO:0072088)2.78879795
137cobalamin metabolic process (GO:0009235)2.78723547
138sulfur compound transport (GO:0072348)2.77609666
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.77000560
140preassembly of GPI anchor in ER membrane (GO:0016254)2.74667508
141indole-containing compound metabolic process (GO:0042430)2.74573552
142glutamate metabolic process (GO:0006536)2.74240648
143beta-amyloid metabolic process (GO:0050435)2.74187928
144glycerol metabolic process (GO:0006071)2.73999474
145RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73759891
146pyrimidine nucleobase catabolic process (GO:0006208)2.73345899
147axoneme assembly (GO:0035082)2.72875852
148carboxylic acid catabolic process (GO:0046395)2.72359127
149organic acid catabolic process (GO:0016054)2.72359127
150regulation of cilium movement (GO:0003352)2.72217101
151protein K11-linked deubiquitination (GO:0035871)2.71745466
152protein neddylation (GO:0045116)2.71586305
153anterograde synaptic vesicle transport (GO:0048490)2.69522207
154embryonic epithelial tube formation (GO:0001838)2.67420248
155cAMP catabolic process (GO:0006198)2.67367213
156neurotransmitter metabolic process (GO:0042133)2.67325360
157GPI anchor metabolic process (GO:0006505)2.67245861
158neurotransmitter catabolic process (GO:0042135)2.66555125
159multicellular organism reproduction (GO:0032504)2.66032526
160cell proliferation in forebrain (GO:0021846)2.63925586
161rhodopsin mediated signaling pathway (GO:0016056)2.63578698
162maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63362562
163fucosylation (GO:0036065)2.62364535
164nucleobase catabolic process (GO:0046113)2.61236216
165nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61015501
166cilium organization (GO:0044782)2.59552840
167negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58455001
168retinal cone cell development (GO:0046549)2.57753532
169ubiquinone biosynthetic process (GO:0006744)2.57015414
170sulfation (GO:0051923)2.55197209
171photoreceptor cell maintenance (GO:0045494)2.54745554
172single strand break repair (GO:0000012)2.54743197
173detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.53345107
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51816604
175meiotic chromosome segregation (GO:0045132)2.51113958
176vitamin biosynthetic process (GO:0009110)2.50782220
177cilium assembly (GO:0042384)2.49944027
178protein-cofactor linkage (GO:0018065)2.48817229
179epithelial tube formation (GO:0072175)2.47933226
180negative regulation of mast cell activation (GO:0033004)2.47555163
181male meiosis I (GO:0007141)2.47464264
182kynurenine metabolic process (GO:0070189)2.46945152
183regulation of acrosome reaction (GO:0060046)2.46154652
184positive regulation of action potential (GO:0045760)2.45405396
185adenosine metabolic process (GO:0046085)2.43963314
186respiratory chain complex IV assembly (GO:0008535)2.42734131
187positive regulation of oligodendrocyte differentiation (GO:0048714)2.42370641
188ncRNA catabolic process (GO:0034661)2.40511609
189nonmotile primary cilium assembly (GO:0035058)2.39878620
190regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.39743905
191action potential (GO:0001508)2.38871949
192protein polyglutamylation (GO:0018095)2.38146165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.02620732
2GBX2_23144817_ChIP-Seq_PC3_Human2.94702444
3VDR_22108803_ChIP-Seq_LS180_Human2.44991676
4FUS_26573619_Chip-Seq_HEK293_Human2.31837258
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15048673
6IRF1_19129219_ChIP-ChIP_H3396_Human2.13308903
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.11212001
8TAF15_26573619_Chip-Seq_HEK293_Human2.08625987
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06212765
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04792773
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04301695
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02131881
13EZH2_27304074_Chip-Seq_ESCs_Mouse1.90375324
14EWS_26573619_Chip-Seq_HEK293_Human1.88084177
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85674115
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84519126
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83953824
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.82703899
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.82002233
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78384180
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78384180
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78376847
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77274752
24RXR_22158963_ChIP-Seq_LIVER_Mouse1.72149630
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.68048185
26CBP_20019798_ChIP-Seq_JUKART_Human1.66258053
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66258053
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66094145
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65146721
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64178865
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63476007
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.62157956
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61505773
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.60401773
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59807023
36AR_25329375_ChIP-Seq_VCAP_Human1.58340370
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.57452739
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56818916
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56385658
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56385658
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55114009
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.53767919
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53532348
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52836156
45STAT3_23295773_ChIP-Seq_U87_Human1.51054239
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48933044
47TCF4_23295773_ChIP-Seq_U87_Human1.48116749
48BCAT_22108803_ChIP-Seq_LS180_Human1.47116822
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45261072
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.42843477
51ER_23166858_ChIP-Seq_MCF-7_Human1.42205265
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41963205
53TP53_22573176_ChIP-Seq_HFKS_Human1.39458200
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38983859
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.38943910
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38254345
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38242591
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36556026
59AR_21572438_ChIP-Seq_LNCaP_Human1.36113345
60MYC_18940864_ChIP-ChIP_HL60_Human1.35257688
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34395656
62SMAD3_21741376_ChIP-Seq_HESCs_Human1.34146237
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33616667
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32307241
65CDX2_20551321_ChIP-Seq_CACO-2_Human1.31247342
66* RUNX2_22187159_ChIP-Seq_PCA_Human1.27777787
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.27730797
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26283956
69IGF1R_20145208_ChIP-Seq_DFB_Human1.26083777
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25557608
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.25428931
72P300_19829295_ChIP-Seq_ESCs_Human1.25274812
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.24677316
74TCF4_22108803_ChIP-Seq_LS180_Human1.24631643
75NCOR_22424771_ChIP-Seq_293T_Human1.24046951
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23590317
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23148744
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.23024275
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22930793
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22374118
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.21116647
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20591902
83REST_21632747_ChIP-Seq_MESCs_Mouse1.20447320
84PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19956233
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.19885144
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19662667
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19210371
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.19210371
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.19110061
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.18572508
91* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17175788
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16878347
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16641692
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15049062
95GATA3_21878914_ChIP-Seq_MCF-7_Human1.13732795
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.13692264
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13061814
98DROSHA_22980978_ChIP-Seq_HELA_Human1.12596225
99HTT_18923047_ChIP-ChIP_STHdh_Human1.12517563
100AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12323007
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.11522478
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11157274
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10889795
104* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10228619
105* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10064147
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09708394
107SMAD4_21799915_ChIP-Seq_A2780_Human1.09142679
108AHR_22903824_ChIP-Seq_MCF-7_Human1.08588452
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.05916329
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05704295
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05661974
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05584942
113NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05383443
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05383443
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04786020
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04782150
117EZH2_22144423_ChIP-Seq_EOC_Human1.04583595
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03562240
119PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03287533
120NANOG_20526341_ChIP-Seq_ESCs_Human1.02975846
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02136658
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01726708
123TAL1_26923725_Chip-Seq_HPCs_Mouse1.01471502
124CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01273275
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.01256910
126HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01217163
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.01014387
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.01012148
129TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00694305
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00534634
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00465794
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.99929207
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.99218319
134* CDX2_22108803_ChIP-Seq_LS180_Human0.98967893
135HOXB7_26014856_ChIP-Seq_BT474_Human0.98784595
136SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98736286
137NANOG_19829295_ChIP-Seq_ESCs_Human0.98218500
138SOX2_19829295_ChIP-Seq_ESCs_Human0.98218500
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97963046
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97090036
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97014363
142TP53_16413492_ChIP-PET_HCT116_Human0.96879639
143* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94458977
144CMYC_18555785_Chip-Seq_ESCs_Mouse0.93473612
145* SMAD4_21741376_ChIP-Seq_EPCs_Human0.93251054
146P53_22387025_ChIP-Seq_ESCs_Mouse0.92129391
147P300_18555785_Chip-Seq_ESCs_Mouse0.91792033
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91630985
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91368312
150OCT4_18555785_Chip-Seq_ESCs_Mouse0.90607555
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90417491
152E2F1_18555785_Chip-Seq_ESCs_Mouse0.90123785
153TP53_18474530_ChIP-ChIP_U2OS_Human0.89317670
154* RNF2_27304074_Chip-Seq_NSC_Mouse0.89258811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation6.63009716
2MP0005360_urolithiasis5.83093024
3MP0005332_abnormal_amino_acid4.32419432
4MP0004019_abnormal_vitamin_homeostasis4.29615494
5MP0003195_calcinosis3.64799431
6MP0002139_abnormal_hepatobiliary_system3.54191366
7MP0001765_abnormal_ion_homeostasis3.49140368
8MP0009643_abnormal_urine_homeostasis3.22773290
9MP0001968_abnormal_touch/_nociception3.14316579
10MP0002138_abnormal_hepatobiliary_system3.06124960
11MP0000569_abnormal_digit_pigmentation2.96262158
12MP0005636_abnormal_mineral_homeostasis2.63446436
13MP0004885_abnormal_endolymph2.59509860
14MP0005377_hearing/vestibular/ear_phenot2.58352344
15MP0003878_abnormal_ear_physiology2.58352344
16MP0008875_abnormal_xenobiotic_pharmacok2.56096510
17MP0001958_emphysema2.52470963
18MP0002136_abnormal_kidney_physiology2.36549078
19MP0000920_abnormal_myelination2.26423647
20MP0003646_muscle_fatigue2.24074994
21MP0002736_abnormal_nociception_after2.17842240
22MP0008877_abnormal_DNA_methylation2.17455665
23MP0001501_abnormal_sleep_pattern2.13726072
24MP0005174_abnormal_tail_pigmentation2.13514429
25MP0001756_abnormal_urination2.12849410
26MP0004742_abnormal_vestibular_system2.10909517
27MP0003787_abnormal_imprinting1.96826815
28MP0005058_abnormal_lysosome_morphology1.94370806
29MP0001529_abnormal_vocalization1.93436940
30MP0004133_heterotaxia1.91581486
31MP0008872_abnormal_physiological_respon1.88428933
32MP0002638_abnormal_pupillary_reflex1.83759576
33MP0002938_white_spotting1.80873688
34MP0000427_abnormal_hair_cycle1.78683548
35MP0001485_abnormal_pinna_reflex1.77133646
36MP0005451_abnormal_body_composition1.73282141
37MP0003252_abnormal_bile_duct1.73032043
38MP0003283_abnormal_digestive_organ1.71299915
39MP0001986_abnormal_taste_sensitivity1.70046441
40MP0001661_extended_life_span1.69005967
41MP0005085_abnormal_gallbladder_physiolo1.68801589
42MP0006292_abnormal_olfactory_placode1.56643951
43MP0004147_increased_porphyrin_level1.49945096
44MP0002234_abnormal_pharynx_morphology1.49815239
45MP0005646_abnormal_pituitary_gland1.49119742
46MP0005389_reproductive_system_phenotype1.48618287
47MP0005253_abnormal_eye_physiology1.47976826
48MP0003136_yellow_coat_color1.47151286
49MP0003186_abnormal_redox_activity1.45488594
50MP0005084_abnormal_gallbladder_morpholo1.44650400
51MP0002837_dystrophic_cardiac_calcinosis1.41800925
52MP0001919_abnormal_reproductive_system1.41422710
53MP0000383_abnormal_hair_follicle1.38492120
54MP0003690_abnormal_glial_cell1.37943461
55MP0002733_abnormal_thermal_nociception1.37736052
56MP0006276_abnormal_autonomic_nervous1.37296311
57MP0008058_abnormal_DNA_repair1.30964962
58MP0005584_abnormal_enzyme/coenzyme_acti1.29570960
59MP0001970_abnormal_pain_threshold1.27204164
60MP0000372_irregular_coat_pigmentation1.27042673
61MP0002876_abnormal_thyroid_physiology1.26474965
62MP0004924_abnormal_behavior1.22288457
63MP0005386_behavior/neurological_phenoty1.22288457
64MP0001293_anophthalmia1.21964026
65MP0002160_abnormal_reproductive_system1.20116072
66MP0003329_amyloid_beta_deposits1.19485892
67MP0000566_synostosis1.18654401
68MP0005365_abnormal_bile_salt1.18379626
69MP0000538_abnormal_urinary_bladder1.18055054
70MP0005187_abnormal_penis_morphology1.17376586
71MP0001486_abnormal_startle_reflex1.16087108
72MP0002572_abnormal_emotion/affect_behav1.15905582
73MP0006072_abnormal_retinal_apoptosis1.15458026
74MP0009046_muscle_twitch1.14758423
75MP0002734_abnormal_mechanical_nocicepti1.14730393
76MP0001963_abnormal_hearing_physiology1.13893045
77MP0003718_maternal_effect1.12759734
78MP0002557_abnormal_social/conspecific_i1.12365060
79MP0008260_abnormal_autophagy1.12177144
80MP0002095_abnormal_skin_pigmentation1.11544291
81MP0003011_delayed_dark_adaptation1.10400871
82MP0004130_abnormal_muscle_cell1.09096487
83MP0005647_abnormal_sex_gland1.08027312
84MP0000230_abnormal_systemic_arterial1.07670134
85MP0005409_darkened_coat_color1.06624458
86MP0001324_abnormal_eye_pigmentation1.05731300
87MP0003121_genomic_imprinting1.05407944
88MP0003806_abnormal_nucleotide_metabolis1.05005102
89MP0002063_abnormal_learning/memory/cond1.04349220
90MP0000015_abnormal_ear_pigmentation1.04228985
91MP0004142_abnormal_muscle_tone1.03975683
92MP0005075_abnormal_melanosome_morpholog1.03437320
93MP0003938_abnormal_ear_development1.02967335
94MP0005670_abnormal_white_adipose1.02316327
95MP0005195_abnormal_posterior_eye1.00326536
96MP0000026_abnormal_inner_ear0.96652035
97MP0003937_abnormal_limbs/digits/tail_de0.96607898
98MP0003880_abnormal_central_pattern0.95984672
99MP0005535_abnormal_body_temperature0.95632552
100MP0006035_abnormal_mitochondrial_morpho0.94711876
101MP0004270_analgesia0.93272051
102MP0002064_seizures0.93175787
103MP0005666_abnormal_adipose_tissue0.93108912
104MP0002896_abnormal_bone_mineralization0.91348404
105MP0003635_abnormal_synaptic_transmissio0.90274070
106MP0002229_neurodegeneration0.88733320
107MP0003950_abnormal_plasma_membrane0.88130933
108MP0002277_abnormal_respiratory_mucosa0.87331010
109MP0008775_abnormal_heart_ventricle0.85197265
110MP0002168_other_aberrant_phenotype0.84922079
111MP0006036_abnormal_mitochondrial_physio0.84545356
112MP0000647_abnormal_sebaceous_gland0.84034256
113MP0005645_abnormal_hypothalamus_physiol0.82700265
114MP0003119_abnormal_digestive_system0.81963528
115MP0000049_abnormal_middle_ear0.81545389
116MP0002102_abnormal_ear_morphology0.81179142
117MP0002909_abnormal_adrenal_gland0.80666612
118MP0005391_vision/eye_phenotype0.78947359
119MP0002272_abnormal_nervous_system0.77830156
120MP0002796_impaired_skin_barrier0.77536848
121MP0002098_abnormal_vibrissa_morphology0.77097382
122MP0000747_muscle_weakness0.76135856
123MP0000762_abnormal_tongue_morphology0.75751246
124MP0002067_abnormal_sensory_capabilities0.75469619
125MP0001440_abnormal_grooming_behavior0.75306404
126MP0003122_maternal_imprinting0.75160285
127MP0003634_abnormal_glial_cell0.75137156
128MP0003698_abnormal_male_reproductive0.74896508
129MP0002254_reproductive_system_inflammat0.74753900
130MP0002118_abnormal_lipid_homeostasis0.71562592
131MP0003172_abnormal_lysosome_physiology0.71417650
132MP0004381_abnormal_hair_follicle0.70949114
133MP0005408_hypopigmentation0.70610437
134MP0009745_abnormal_behavioral_response0.70008233
135MP0003633_abnormal_nervous_system0.69040359
136MP0005319_abnormal_enzyme/_coenzyme0.68830150
137MP0000778_abnormal_nervous_system0.68804342
138MP0001905_abnormal_dopamine_level0.66824832
139MP0002928_abnormal_bile_duct0.64822886
140MP0005501_abnormal_skin_physiology0.62276767
141MP0001664_abnormal_digestion0.60874512
142MP0002066_abnormal_motor_capabilities/c0.58321911
143MP0003631_nervous_system_phenotype0.57584042
144MP0009780_abnormal_chondrocyte_physiolo0.57264391
145MP0001764_abnormal_homeostasis0.56768537
146MP0002249_abnormal_larynx_morphology0.56351496
147MP0005595_abnormal_vascular_smooth0.55747273
148MP0001727_abnormal_embryo_implantation0.55535786
149MP0000163_abnormal_cartilage_morphology0.55168358
150MP0003879_abnormal_hair_cell0.54903243
151MP0008961_abnormal_basal_metabolism0.54684219
152MP0005551_abnormal_eye_electrophysiolog0.54220932
153MP0005165_increased_susceptibility_to0.53835026
154MP0002135_abnormal_kidney_morphology0.53609986
155MP0002115_abnormal_skeleton_extremities0.53483332
156MP0002089_abnormal_postnatal_growth/wei0.53367657
157MP0003724_increased_susceptibility_to0.52682093
158MP0002069_abnormal_eating/drinking_beha0.52649522
159MP0010386_abnormal_urinary_bladder0.52640265
160MP0002735_abnormal_chemical_nociception0.52261813
161MP0003638_abnormal_response/metabolism_0.51392505
162MP0010678_abnormal_skin_adnexa0.50754423
163MP0000631_abnormal_neuroendocrine_gland0.49357482

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.67202266
2Metabolic alkalosis (HP:0200114)7.52206365
3Hypokalemic alkalosis (HP:0001949)7.27096430
4Hypomagnesemia (HP:0002917)7.03329297
5Hyperactive renin-angiotensin system (HP:0000841)6.02555155
6Abnormality of chloride homeostasis (HP:0011422)5.96306864
7Polyuria (HP:0000103)5.96007901
8Abnormality of magnesium homeostasis (HP:0004921)5.78152075
9Gout (HP:0001997)5.66523814
10Abnormal urine output (HP:0012590)5.51514600
11Abnormality of renal excretion (HP:0011036)5.41531353
12Abnormal drinking behavior (HP:0030082)4.93635796
13Polydipsia (HP:0001959)4.93635796
14Proximal tubulopathy (HP:0000114)4.91531754
15Abnormality of renin-angiotensin system (HP:0000847)4.72477481
16Alkalosis (HP:0001948)4.64973448
17Hyperaldosteronism (HP:0000859)4.50191816
18Renal salt wasting (HP:0000127)4.44251220
19Tetany (HP:0001281)4.42345894
20Hyperuricemia (HP:0002149)4.04441153
21Increased purine levels (HP:0004368)4.04441153
22Congenital stationary night blindness (HP:0007642)4.01662180
23Pancreatic cysts (HP:0001737)3.98071490
24Molar tooth sign on MRI (HP:0002419)3.88679734
25Abnormality of midbrain morphology (HP:0002418)3.88679734
26True hermaphroditism (HP:0010459)3.88583263
27Hyperglycinuria (HP:0003108)3.81864521
28Generalized aminoaciduria (HP:0002909)3.75884829
29Pancreatic fibrosis (HP:0100732)3.74483074
30Abnormality of urine glucose concentration (HP:0011016)3.69652113
31Glycosuria (HP:0003076)3.69652113
32Abnormality of purine metabolism (HP:0004352)3.69646386
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.68836764
34Hypercalciuria (HP:0002150)3.57266778
35Hypokalemia (HP:0002900)3.51419402
36Abnormality of serine family amino acid metabolism (HP:0010894)3.48734769
37Abnormality of glycine metabolism (HP:0010895)3.48734769
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.37162839
39Abnormality of alanine metabolism (HP:0010916)3.37162839
40Hyperalaninemia (HP:0003348)3.37162839
41Nephronophthisis (HP:0000090)3.35415495
42Abnormal urine phosphate concentration (HP:0012599)3.26782554
43Abnormality of the renal cortex (HP:0011035)3.26324846
44Abnormality of potassium homeostasis (HP:0011042)3.22912847
45Delayed epiphyseal ossification (HP:0002663)3.18621232
46Hyperphosphaturia (HP:0003109)3.16220729
47Renal cortical cysts (HP:0000803)3.09938121
48Ketoacidosis (HP:0001993)3.09639633
49Renal tubular acidosis (HP:0001947)3.04855955
50Abnormality of the renal medulla (HP:0100957)2.99630515
51Vascular calcification (HP:0004934)2.93980615
52Rickets (HP:0002748)2.90280638
53Congenital, generalized hypertrichosis (HP:0004540)2.88259159
54Thyroid-stimulating hormone excess (HP:0002925)2.83475495
55Hypophosphatemia (HP:0002148)2.80158464
56Ketosis (HP:0001946)2.78689063
57Abnormality of renal resorption (HP:0011038)2.77214565
58Nephrocalcinosis (HP:0000121)2.75261303
593-Methylglutaconic aciduria (HP:0003535)2.74841557
60Medial flaring of the eyebrow (HP:0010747)2.74348618
61Abnormality of nucleobase metabolism (HP:0010932)2.61511499
62Type II lissencephaly (HP:0007260)2.60587790
63Cystic liver disease (HP:0006706)2.59795351
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.59328585
65Confusion (HP:0001289)2.58304798
66Progressive inability to walk (HP:0002505)2.56716269
67Cardiovascular calcification (HP:0011915)2.56306781
68Enlarged kidneys (HP:0000105)2.54103188
69Nephrogenic diabetes insipidus (HP:0009806)2.53313767
70Chronic hepatic failure (HP:0100626)2.52649835
71Broad-based gait (HP:0002136)2.50661347
72Hypophosphatemic rickets (HP:0004912)2.50373111
73Inability to walk (HP:0002540)2.49963598
74Hyperglycinemia (HP:0002154)2.48759505
75Nephrolithiasis (HP:0000787)2.48573689
76Vacuolated lymphocytes (HP:0001922)2.45806005
77Abnormality of macular pigmentation (HP:0008002)2.42103433
78Attenuation of retinal blood vessels (HP:0007843)2.40932050
79Lissencephaly (HP:0001339)2.40395698
80Large for gestational age (HP:0001520)2.39242186
81Intestinal atresia (HP:0011100)2.38915108
82Abnormal rod and cone electroretinograms (HP:0008323)2.38544278
83Gait imbalance (HP:0002141)2.36225278
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.33766836
85Widely patent fontanelles and sutures (HP:0004492)2.33055630
86Abnormality of proline metabolism (HP:0010907)2.31964749
87Hydroxyprolinuria (HP:0003080)2.31964749
88Renal tubular dysfunction (HP:0000124)2.29737944
89Decreased central vision (HP:0007663)2.25574749
90Dehydration (HP:0001944)2.24733226
91Delayed CNS myelination (HP:0002188)2.24257010
92Sclerocornea (HP:0000647)2.23969876
93Gaze-evoked nystagmus (HP:0000640)2.23936603
94Colon cancer (HP:0003003)2.22831729
95Abnormal enzyme/coenzyme activity (HP:0012379)2.21523433
96Methylmalonic aciduria (HP:0012120)2.21130460
97Abnormal respiratory motile cilium morphology (HP:0005938)2.20992590
98Abnormal respiratory epithelium morphology (HP:0012253)2.20992590
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20737823
100Volvulus (HP:0002580)2.20562608
101Anencephaly (HP:0002323)2.19614714
102Fair hair (HP:0002286)2.19387220
103Hyponatremia (HP:0002902)2.17792673
104Furrowed tongue (HP:0000221)2.17771953
105Congenital primary aphakia (HP:0007707)2.16746646
106Metaphyseal dysplasia (HP:0100255)2.16710615
107Abnormality of alkaline phosphatase activity (HP:0004379)2.16664792
108Male pseudohermaphroditism (HP:0000037)2.13538513
109Protruding tongue (HP:0010808)2.13243584
110Hyperkalemia (HP:0002153)2.12285796
111Abnormality of aromatic amino acid family metabolism (HP:0004338)2.12184824
112Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11323378
113Dicarboxylic aciduria (HP:0003215)2.11323378
114Drooling (HP:0002307)2.11123836
115Increased corneal curvature (HP:0100692)2.10510424
116Keratoconus (HP:0000563)2.10510424
117Metabolic acidosis (HP:0001942)2.08544174
118Abnormality of fatty-acid metabolism (HP:0004359)2.06278456
119Metaphyseal irregularity (HP:0003025)2.03275334
120Methylmalonic acidemia (HP:0002912)2.03208820
121Hyperventilation (HP:0002883)2.03122436
122Abnormality of sodium homeostasis (HP:0010931)2.02952576
123Pendular nystagmus (HP:0012043)2.02932481
124Focal motor seizures (HP:0011153)2.00982689
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.97596057
126Vomiting (HP:0002013)1.96738520
127Aplasia/Hypoplasia of the fovea (HP:0008060)1.96250366
128Hypoplasia of the fovea (HP:0007750)1.96250366
129Increased CSF lactate (HP:0002490)1.96217266
130Partial agenesis of the corpus callosum (HP:0001338)1.95266631
131Stomach cancer (HP:0012126)1.94998950
132Abnormality of the fovea (HP:0000493)1.94832984
133Optic disc pallor (HP:0000543)1.93259208
134Abnormal tarsal ossification (HP:0008369)1.93245665
135Oligodactyly (hands) (HP:0001180)1.93189066
136Generalized hypopigmentation of hair (HP:0011358)1.91962731
137Abolished electroretinogram (ERG) (HP:0000550)1.91509726
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.91398346
139Absent/shortened dynein arms (HP:0200106)1.91398346
140Excessive salivation (HP:0003781)1.89264430
141Mitochondrial inheritance (HP:0001427)1.89241764
142Hypoplasia of the uterus (HP:0000013)1.89138284
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.88412002
144Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88412002
145Severe muscular hypotonia (HP:0006829)1.86602551
146Bile duct proliferation (HP:0001408)1.86356216
147Abnormal biliary tract physiology (HP:0012439)1.86356216
148Genetic anticipation (HP:0003743)1.86238358
149Axonal loss (HP:0003447)1.85973343
150Elevated alkaline phosphatase (HP:0003155)1.85910609
151Lethargy (HP:0001254)1.85177601
152Hemiparesis (HP:0001269)1.85052973
153Absent speech (HP:0001344)1.84371839
154Hyperammonemia (HP:0001987)1.83546049
155Congenital hepatic fibrosis (HP:0002612)1.82332030
156Agitation (HP:0000713)1.79712805
157Tubulointerstitial fibrosis (HP:0005576)1.79676924
158Abnormality of the costochondral junction (HP:0000919)1.79185258
159Abnormality of calcium-phosphate metabolism (HP:0100530)1.78000710
160Enlarged epiphyses (HP:0010580)1.77892779
161Metaphyseal cupping (HP:0003021)1.77183878
162Bilateral microphthalmos (HP:0007633)1.76254083
163Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76018684
164Short tibia (HP:0005736)1.76015862
165Cerebellar dysplasia (HP:0007033)1.75792282
166Prolonged neonatal jaundice (HP:0006579)1.75600329
167Abnormality of B cell number (HP:0010975)1.74427977
168Decreased circulating renin level (HP:0003351)1.74132609
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74039130
170Focal seizures (HP:0007359)1.73207177
171Genital tract atresia (HP:0001827)1.72570417
172Vaginal atresia (HP:0000148)1.71862057
173Adrenal overactivity (HP:0002717)1.70061556
174Tubular atrophy (HP:0000092)1.69857482
175Abnormality of the vitamin B12 metabolism (HP:0004341)1.67300470
176Malnutrition (HP:0004395)1.63511567
177Glomerulosclerosis (HP:0000096)1.63384064
178Abnormal auditory evoked potentials (HP:0006958)1.63345662
179Parakeratosis (HP:0001036)1.63082741
180Abnormality of serum amino acid levels (HP:0003112)1.62730411
181Increased serum pyruvate (HP:0003542)1.62518029
182Abnormality of glycolysis (HP:0004366)1.62518029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.08095485
2OXSR17.35938375
3STK396.41734644
4WNK35.36493929
5FRK4.25356630
6MAP4K23.26580503
7NUAK12.49943481
8WNK12.42945893
9BLK2.36803232
10ZAK2.30005137
11TLK12.05782854
12MAPK131.99058890
13EPHB11.92544212
14VRK21.78226799
15BCKDK1.71378152
16CASK1.69582404
17TAOK31.67994879
18SGK2231.65062514
19SGK4941.65062514
20PLK41.62234207
21MST41.60213185
22MAP3K41.46724615
23PKN11.44367084
24DAPK21.41623110
25ACVR1B1.41141356
26TAF11.34398350
27TGFBR11.31807384
28ADRBK11.26521939
29PRKCG1.23754204
30PRKCI1.20311546
31STK38L1.17533455
32PBK1.10184321
33PLK21.10069771
34PDK31.05853847
35PDK41.05853847
36MET1.03940196
37INSRR1.03636463
38VRK11.03575017
39DYRK20.99709112
40TNIK0.97256800
41BCR0.95482240
42PNCK0.93711099
43MAP2K70.93253640
44PDK20.89749118
45WEE10.88875007
46NEK60.83233180
47MST1R0.79458801
48EIF2AK20.76928784
49MAPK150.76547980
50TXK0.74098375
51GSK3A0.72320423
52MAPKAPK50.67510069
53IRAK10.67167684
54MKNK20.66982301
55EPHA40.65375021
56BRSK20.64865896
57NTRK10.63932281
58PAK30.63746133
59CCNB10.63329733
60ROCK20.63057630
61CAMK2B0.62821841
62TRPM70.62626352
63CSNK1G10.62451328
64STK30.62385209
65NLK0.61908923
66IRAK20.61044737
67SGK10.60521262
68CSNK1A1L0.59009198
69CAMKK20.58426156
70PDPK10.57974294
71DYRK30.56588630
72FGR0.56274504
73ERBB30.55727990
74PINK10.54234332
75STK240.54173282
76PRKAA20.52967966
77MAP3K140.52613010
78PRKCQ0.52117649
79CHEK20.50605430
80STK380.50485021
81NTRK30.50455595
82CSNK1G30.49749084
83FLT30.49031305
84GRK10.48370776
85OBSCN0.48097534
86PLK30.47465400
87FGFR20.46910292
88CSNK1G20.46682560
89CDK190.45940289
90FER0.45129376
91MAPKAPK30.45116490
92KIT0.44443802
93PLK10.44081824
94MAP2K20.43561498
95IKBKB0.43242364
96PTK20.43237172
97ERBB40.43209189
98GRK50.43099964
99CAMK1G0.42735292
100STK110.42652310
101CLK10.42156596
102PRKAA10.40966141
103PRKCE0.40534989
104CSNK1A10.40359702
105MAP3K70.39939071
106MAP3K130.38677662
107PRKD20.38661243
108TIE10.38110781
109MARK20.37200147
110MAP2K10.36981713
111GRK70.36688354
112CSNK1D0.36490647
113EIF2AK30.36369515
114CAMK2A0.36354205
115TRIM280.36196321
116CAMK2D0.35674666
117MAP2K60.35305918
118SGK20.34487608
119ABL20.34437375
120UHMK10.34428849
121CAMK2G0.32739332
122ADRBK20.32508071
123MKNK10.32258888
124SYK0.31607725
125PDK10.30283982
126PRKACA0.30236152
127PIK3CA0.30216845
128CDK50.29748532
129PRKD10.29554787
130PAK60.29242001
131FYN0.28064674
132TEC0.27753691
133BMPR1B0.27550727
134LIMK10.26176419
135GRK60.25809476
136PTK2B0.25495566
137FES0.24843240
138CHUK0.24482970
139PRKACB0.24208583
140INSR0.23784799
141NME10.23716149
142DYRK1A0.23610896
143MUSK0.23595667
144PHKG10.22724033
145PHKG20.22724033
146MARK10.21037866
147FGFR40.20427888
148CSK0.20251897
149ROCK10.20154568
150PRKCA0.19397717
151PRKCZ0.19006328
152STK160.18659757
153SGK30.18113369
154MAPK120.17450156

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.35646354
2Butanoate metabolism_Homo sapiens_hsa006504.08792748
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.16627891
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.97736382
5Propanoate metabolism_Homo sapiens_hsa006402.87895045
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73789835
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.71378797
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.68002069
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.61204966
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.48122066
11Peroxisome_Homo sapiens_hsa041462.36907991
12Collecting duct acid secretion_Homo sapiens_hsa049662.26011679
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18214432
14Sulfur metabolism_Homo sapiens_hsa009202.13200551
15Pyruvate metabolism_Homo sapiens_hsa006202.12050840
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.11000120
17Homologous recombination_Homo sapiens_hsa034402.07359480
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00069127
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96444739
20Nicotine addiction_Homo sapiens_hsa050331.91356975
21Vitamin digestion and absorption_Homo sapiens_hsa049771.87329539
22Olfactory transduction_Homo sapiens_hsa047401.85646021
23beta-Alanine metabolism_Homo sapiens_hsa004101.85635265
24Tryptophan metabolism_Homo sapiens_hsa003801.84623189
25Fatty acid degradation_Homo sapiens_hsa000711.82781219
26Arginine and proline metabolism_Homo sapiens_hsa003301.81018454
27Fatty acid elongation_Homo sapiens_hsa000621.80272168
28Histidine metabolism_Homo sapiens_hsa003401.74463549
29Steroid biosynthesis_Homo sapiens_hsa001001.68169015
30Caffeine metabolism_Homo sapiens_hsa002321.65756681
31Fatty acid metabolism_Homo sapiens_hsa012121.63001980
32Glutathione metabolism_Homo sapiens_hsa004801.52663869
33Basal transcription factors_Homo sapiens_hsa030221.47816925
34RNA polymerase_Homo sapiens_hsa030201.46837235
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44110230
36Fanconi anemia pathway_Homo sapiens_hsa034601.37594296
37Mineral absorption_Homo sapiens_hsa049781.37144290
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.35968632
39Protein export_Homo sapiens_hsa030601.31570513
40Morphine addiction_Homo sapiens_hsa050321.31106790
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29930959
42Other glycan degradation_Homo sapiens_hsa005111.29364980
43Oxidative phosphorylation_Homo sapiens_hsa001901.29361163
44Bile secretion_Homo sapiens_hsa049761.27566476
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27480905
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24344860
47RNA degradation_Homo sapiens_hsa030181.14447970
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12830733
49Ovarian steroidogenesis_Homo sapiens_hsa049131.07221050
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.05985105
51Protein digestion and absorption_Homo sapiens_hsa049741.05938652
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04410304
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96924271
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96539713
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.95210991
56Insulin secretion_Homo sapiens_hsa049110.94190935
57Circadian entrainment_Homo sapiens_hsa047130.92939449
58PPAR signaling pathway_Homo sapiens_hsa033200.92796585
59Sphingolipid metabolism_Homo sapiens_hsa006000.92449502
60Starch and sucrose metabolism_Homo sapiens_hsa005000.89656740
61Basal cell carcinoma_Homo sapiens_hsa052170.89093882
62Hedgehog signaling pathway_Homo sapiens_hsa043400.88899146
63Folate biosynthesis_Homo sapiens_hsa007900.88847154
64Phenylalanine metabolism_Homo sapiens_hsa003600.88774632
65Carbon metabolism_Homo sapiens_hsa012000.88202691
66Glycerolipid metabolism_Homo sapiens_hsa005610.87669034
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85738070
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82679619
69Arachidonic acid metabolism_Homo sapiens_hsa005900.81311841
70Lysine degradation_Homo sapiens_hsa003100.80102931
71Fat digestion and absorption_Homo sapiens_hsa049750.79361320
72Calcium signaling pathway_Homo sapiens_hsa040200.77162456
73Circadian rhythm_Homo sapiens_hsa047100.75483985
74Primary immunodeficiency_Homo sapiens_hsa053400.75370127
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73876417
76Ether lipid metabolism_Homo sapiens_hsa005650.73241076
77Glutamatergic synapse_Homo sapiens_hsa047240.72692701
78Gastric acid secretion_Homo sapiens_hsa049710.71684382
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71478767
80Parkinsons disease_Homo sapiens_hsa050120.71363587
81Retinol metabolism_Homo sapiens_hsa008300.71053200
82Purine metabolism_Homo sapiens_hsa002300.67852378
83Nitrogen metabolism_Homo sapiens_hsa009100.66182094
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65978360
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65187010
86Chemical carcinogenesis_Homo sapiens_hsa052040.62750762
87Sulfur relay system_Homo sapiens_hsa041220.62146172
88Metabolic pathways_Homo sapiens_hsa011000.61954558
89Lysosome_Homo sapiens_hsa041420.58690747
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57799364
91Dorso-ventral axis formation_Homo sapiens_hsa043200.57711524
92Fatty acid biosynthesis_Homo sapiens_hsa000610.57592373
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.56735768
94Arginine biosynthesis_Homo sapiens_hsa002200.54485515
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52675132
96Regulation of autophagy_Homo sapiens_hsa041400.52101836
97Alzheimers disease_Homo sapiens_hsa050100.51961205
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51697943
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51535541
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.48363495
101Asthma_Homo sapiens_hsa053100.47558674
102Vibrio cholerae infection_Homo sapiens_hsa051100.45912485
103Rheumatoid arthritis_Homo sapiens_hsa053230.45121610
104Cardiac muscle contraction_Homo sapiens_hsa042600.43460254
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42967697
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42707794
107Oxytocin signaling pathway_Homo sapiens_hsa049210.41788347
108One carbon pool by folate_Homo sapiens_hsa006700.41613572
109Long-term depression_Homo sapiens_hsa047300.41433776
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.39678963
111Thyroid hormone synthesis_Homo sapiens_hsa049180.39274326
112Selenocompound metabolism_Homo sapiens_hsa004500.39224152
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38181761
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38134055
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37372618
116Tyrosine metabolism_Homo sapiens_hsa003500.36980695
117Renin-angiotensin system_Homo sapiens_hsa046140.35385021
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33764346
119Choline metabolism in cancer_Homo sapiens_hsa052310.33698069
120Cholinergic synapse_Homo sapiens_hsa047250.33103149
121Dopaminergic synapse_Homo sapiens_hsa047280.30591087
122Non-homologous end-joining_Homo sapiens_hsa034500.30562502
123cAMP signaling pathway_Homo sapiens_hsa040240.28646771
124Synaptic vesicle cycle_Homo sapiens_hsa047210.25598082
125Axon guidance_Homo sapiens_hsa043600.23416792
126Salivary secretion_Homo sapiens_hsa049700.22571258
127ABC transporters_Homo sapiens_hsa020100.21873387
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.21703822
129GABAergic synapse_Homo sapiens_hsa047270.21191492
130Fructose and mannose metabolism_Homo sapiens_hsa000510.19414417
131Linoleic acid metabolism_Homo sapiens_hsa005910.18977085
132Pancreatic secretion_Homo sapiens_hsa049720.18944778
133Serotonergic synapse_Homo sapiens_hsa047260.18091697
134Biosynthesis of amino acids_Homo sapiens_hsa012300.17502085
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16844970
136Inositol phosphate metabolism_Homo sapiens_hsa005620.16805790
137Huntingtons disease_Homo sapiens_hsa050160.16247606
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13315691
139Taste transduction_Homo sapiens_hsa047420.11094098
140Phototransduction_Homo sapiens_hsa047440.10653600

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