SLC7A10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)8.87004822
2triglyceride catabolic process (GO:0019433)8.45724926
3acylglycerol catabolic process (GO:0046464)7.63490644
4neutral lipid catabolic process (GO:0046461)7.63490644
5fatty acid homeostasis (GO:0055089)7.55505642
6diacylglycerol metabolic process (GO:0046339)6.80947347
7glycerolipid catabolic process (GO:0046503)5.83665183
8biotin metabolic process (GO:0006768)5.63459885
9brown fat cell differentiation (GO:0050873)5.53226790
10plasma lipoprotein particle clearance (GO:0034381)5.38269161
11CDP-diacylglycerol biosynthetic process (GO:0016024)5.35584018
12amino acid import (GO:0043090)5.30353643
13L-amino acid import (GO:0043092)5.17472576
14fatty-acyl-CoA metabolic process (GO:0035337)5.09421956
15CDP-diacylglycerol metabolic process (GO:0046341)5.09210380
16lipid storage (GO:0019915)5.07654853
17C4-dicarboxylate transport (GO:0015740)5.00144434
18white fat cell differentiation (GO:0050872)4.96381325
19cellular potassium ion homeostasis (GO:0030007)4.89905094
20regulation of cholesterol storage (GO:0010885)4.77802526
21triglyceride metabolic process (GO:0006641)4.74766693
22negative regulation of astrocyte differentiation (GO:0048712)4.73042672
23fatty acid transmembrane transport (GO:1902001)4.71981969
24long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.66785265
25glycerol metabolic process (GO:0006071)4.64905882
26* alanine transport (GO:0032328)4.52997109
27lipid particle organization (GO:0034389)4.51608032
28acylglycerol metabolic process (GO:0006639)4.41992196
29cellular response to cholesterol (GO:0071397)4.41620924
30sodium ion export (GO:0071436)4.40224818
31proline transport (GO:0015824)4.37022382
32neutral lipid metabolic process (GO:0006638)4.36723793
33positive regulation of lipid storage (GO:0010884)4.34128950
34cell communication by electrical coupling (GO:0010644)4.33437905
35gamma-aminobutyric acid transport (GO:0015812)4.30504278
36response to dietary excess (GO:0002021)4.22805936
37regulation of cAMP-dependent protein kinase activity (GO:2000479)4.09095204
38cGMP-mediated signaling (GO:0019934)4.07218680
39low-density lipoprotein particle remodeling (GO:0034374)4.05924259
40positive regulation of cholesterol efflux (GO:0010875)4.04429988
41alditol metabolic process (GO:0019400)4.04324870
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.97823642
43positive regulation of glomerulus development (GO:0090193)3.97396231
44acetyl-CoA metabolic process (GO:0006084)3.97133044
45carnitine shuttle (GO:0006853)3.93500780
46negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.92720930
47thioester metabolic process (GO:0035383)3.92608065
48acyl-CoA metabolic process (GO:0006637)3.92608065
49response to phenylpropanoid (GO:0080184)3.90915324
50cellular sodium ion homeostasis (GO:0006883)3.89938598
51NADH metabolic process (GO:0006734)3.86707172
52central nervous system myelination (GO:0022010)3.86276705
53axon ensheathment in central nervous system (GO:0032291)3.86276705
54regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.85286027
55retinol metabolic process (GO:0042572)3.77005807
56regulation of phospholipid biosynthetic process (GO:0071071)3.75075303
57neurotransmitter uptake (GO:0001504)3.74580502
58phospholipid homeostasis (GO:0055091)3.70301052
59cellular response to sterol (GO:0036315)3.67230688
60chondroitin sulfate catabolic process (GO:0030207)3.65335204
61atrial cardiac muscle cell action potential (GO:0086014)3.62332489
62potassium ion import (GO:0010107)3.62191115
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.58257791
64regulation of heat generation (GO:0031650)3.57788124
65polyol transport (GO:0015791)3.57655837
66ethanol oxidation (GO:0006069)3.57364036
67positive regulation of sterol transport (GO:0032373)3.57336784
68positive regulation of cholesterol transport (GO:0032376)3.57336784
69acylglycerol homeostasis (GO:0055090)3.56890628
70triglyceride homeostasis (GO:0070328)3.56890628
71negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.54030116
72primary alcohol metabolic process (GO:0034308)3.53947576
73neurotransmitter-gated ion channel clustering (GO:0072578)3.53558339
74positive regulation of cellular amide metabolic process (GO:0034250)3.50700318
75regulation of macrophage derived foam cell differentiation (GO:0010743)3.48495731
76protein heterotrimerization (GO:0070208)3.42143914
77phosphatidic acid biosynthetic process (GO:0006654)3.41435531
78phosphatidic acid metabolic process (GO:0046473)3.41435531
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40026503
80negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39295780
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35237229
82positive regulation of fatty acid oxidation (GO:0046321)3.33718669
83response to auditory stimulus (GO:0010996)3.33338881
84regulation of lipid storage (GO:0010883)3.33024910
85positive regulation of fatty acid metabolic process (GO:0045923)3.32909541
86negative regulation of macrophage differentiation (GO:0045650)3.30682459
87regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.30559148
88* L-serine transport (GO:0015825)3.29711919
89locomotory exploration behavior (GO:0035641)3.28207892
90negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.26989599
91positive regulation of triglyceride biosynthetic process (GO:0010867)3.24877946
92dermatan sulfate biosynthetic process (GO:0030208)3.23816284
93oxaloacetate metabolic process (GO:0006107)3.22737756
94regulation of triglyceride catabolic process (GO:0010896)3.22705183
95glutamate receptor signaling pathway (GO:0007215)3.20755480
96regulation of beta-amyloid formation (GO:1902003)3.19695529
97adenine nucleotide transport (GO:0051503)3.19525957
98potassium ion homeostasis (GO:0055075)3.17183243
99negative regulation of protein autophosphorylation (GO:0031953)3.16306061
100positive regulation of triglyceride metabolic process (GO:0090208)3.15018045
101glial cell proliferation (GO:0014009)3.14705606
102dermatan sulfate metabolic process (GO:0030205)3.13321732
103negative regulation of response to reactive oxygen species (GO:1901032)3.12451872
104regulation of astrocyte differentiation (GO:0048710)3.11955511
105tricarboxylic acid metabolic process (GO:0072350)3.11083463
106positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.10167225
107regulation of triglyceride metabolic process (GO:0090207)3.09931892
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09526939
109negative regulation of sodium ion transport (GO:0010766)3.06679751
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01033359
111glycine transport (GO:0015816)3.00063083
112acidic amino acid transport (GO:0015800)2.98644835
113negative regulation of lipid catabolic process (GO:0050995)2.96745838
114auditory behavior (GO:0031223)2.95991371
115regulation of triglyceride biosynthetic process (GO:0010866)2.95344827
116negative regulation of smoothened signaling pathway (GO:0045879)2.92641307
117cellular response to lithium ion (GO:0071285)2.92489255
118transcytosis (GO:0045056)2.92342609
119negative regulation of gluconeogenesis (GO:0045721)2.89082764
120blood vessel maturation (GO:0001955)2.88244796
121positive regulation of fatty acid beta-oxidation (GO:0032000)2.88069399
122cellular response to epinephrine stimulus (GO:0071872)2.86476472
123ionotropic glutamate receptor signaling pathway (GO:0035235)2.86229326
124coenzyme A biosynthetic process (GO:0015937)2.85009260
125ethanol metabolic process (GO:0006067)2.84732877
126regulation of hydrogen peroxide-induced cell death (GO:1903205)2.84455138
127ovulation cycle (GO:0042698)2.83629302
128regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81657823
129linoleic acid metabolic process (GO:0043651)2.81521271
130negative regulation of lipase activity (GO:0060192)2.80469440
131fatty acid beta-oxidation (GO:0006635)2.78971738
132alpha-linolenic acid metabolic process (GO:0036109)2.76686352
133neuronal action potential propagation (GO:0019227)2.76041115
134short-term memory (GO:0007614)2.75754702
135regulation of glycogen (starch) synthase activity (GO:2000465)2.74851451
136regulation of lipid catabolic process (GO:0050994)2.74728701
137negative regulation of metanephros development (GO:0072217)2.74494822
138negative regulation of execution phase of apoptosis (GO:1900118)2.73600363
139long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.73486754
140transmission of nerve impulse (GO:0019226)2.71926843
141positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71865747
142negative regulation of glial cell differentiation (GO:0045686)2.71483967
143carnitine transmembrane transport (GO:1902603)2.71417598
144somite development (GO:0061053)2.71209247
145* serine transport (GO:0032329)2.70186628
146import into cell (GO:0098657)2.70110999
147negative regulation of DNA biosynthetic process (GO:2000279)2.69954978
148purine nucleotide transport (GO:0015865)2.69919714
149valine metabolic process (GO:0006573)2.69634314
150negative regulation of lipid storage (GO:0010888)2.68009036
151regulation of membrane repolarization (GO:0060306)2.67713422
152activation of protein kinase A activity (GO:0034199)2.67154513
153long-chain fatty acid transport (GO:0015909)2.66826673
154regulation of gonadotropin secretion (GO:0032276)2.65679363
155positive regulation of potassium ion transmembrane transport (GO:1901381)2.65367240
156response to cholesterol (GO:0070723)2.64906386
157positive regulation of lipid catabolic process (GO:0050996)2.64688645
158myelination in peripheral nervous system (GO:0022011)2.64407845
159peripheral nervous system axon ensheathment (GO:0032292)2.64407845
160positive regulation of glycolytic process (GO:0045821)2.63463772
161synaptic transmission, glutamatergic (GO:0035249)2.62099982
162purine ribonucleotide transport (GO:0015868)2.57359141
163response to gravity (GO:0009629)2.54297721
164negative regulation of adenylate cyclase activity (GO:0007194)2.54271551
165regulation of amyloid precursor protein catabolic process (GO:1902991)2.53280609
166fatty-acyl-CoA biosynthetic process (GO:0046949)2.51383584
167endothelium development (GO:0003158)2.49625131
168negative regulation of cytosolic calcium ion concentration (GO:0051481)2.47903669
169neuron cell-cell adhesion (GO:0007158)2.47781791
170triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.46815298
171lens fiber cell development (GO:0070307)2.46807743
172triglyceride biosynthetic process (GO:0019432)2.45788920
173layer formation in cerebral cortex (GO:0021819)2.45157584
174positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.43000235
175vascular smooth muscle contraction (GO:0014829)2.42973985
176polyketide metabolic process (GO:0030638)2.41830476
177doxorubicin metabolic process (GO:0044598)2.41830476
178daunorubicin metabolic process (GO:0044597)2.41830476
179negative regulation of tissue remodeling (GO:0034104)2.41298352
180thioester biosynthetic process (GO:0035384)2.40539087
181acyl-CoA biosynthetic process (GO:0071616)2.40539087
182positive regulation of alcohol biosynthetic process (GO:1902932)2.40259999
183neutral lipid biosynthetic process (GO:0046460)2.39703979
184acylglycerol biosynthetic process (GO:0046463)2.39703979
185positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.39386465
186low-density lipoprotein particle clearance (GO:0034383)10.5831770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.76024286
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.64344987
3GBX2_23144817_ChIP-Seq_PC3_Human3.19341842
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06011087
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98453480
6* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.77202023
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67666293
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65255302
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65255302
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64056393
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.62968012
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.48696136
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48351647
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48042857
15AR_21572438_ChIP-Seq_LNCaP_Human2.38883367
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36065438
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.31382958
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28251966
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.26016254
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22622422
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20447827
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17278310
23CLOCK_20551151_ChIP-Seq_293T_Human2.11844830
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.09770046
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.08963768
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03964975
27DROSHA_22980978_ChIP-Seq_HELA_Human2.02430075
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98668118
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89706394
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87710209
31* EZH2_27294783_Chip-Seq_ESCs_Mouse1.87498722
32* REST_21632747_ChIP-Seq_MESCs_Mouse1.83092495
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.82101231
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81048453
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73620963
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73471590
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71132460
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.70898071
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68612652
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62199081
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.61755585
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.60820230
43* LXR_22158963_ChIP-Seq_LIVER_Mouse1.58715550
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57632609
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57477431
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55141197
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50101051
48RXR_22108803_ChIP-Seq_LS180_Human1.48887485
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46245675
50P300_19829295_ChIP-Seq_ESCs_Human1.45105910
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40775313
52TP53_16413492_ChIP-PET_HCT116_Human1.39835391
53BCAT_22108803_ChIP-Seq_LS180_Human1.33575494
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.32819708
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.32570718
56AR_25329375_ChIP-Seq_VCAP_Human1.31720834
57* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28779396
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28457875
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.28177742
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27679898
61SMAD4_21799915_ChIP-Seq_A2780_Human1.27547647
62CTCF_27219007_Chip-Seq_Bcells_Human1.27183766
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26482314
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25814202
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24617774
66* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23945227
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.20099413
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19354578
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18718436
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18670392
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18512035
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18463867
73TP53_18474530_ChIP-ChIP_U2OS_Human1.17533658
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17389835
75TAF15_26573619_Chip-Seq_HEK293_Human1.17032821
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.16553214
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15956080
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15598812
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14209174
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.11781776
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09968243
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.07111660
83KDM2B_26808549_Chip-Seq_K562_Human1.06663656
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06497726
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05656267
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04892032
87AR_19668381_ChIP-Seq_PC3_Human1.03814740
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02945140
89* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.02410140
90RNF2_27304074_Chip-Seq_NSC_Mouse1.01982190
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01958589
92RUNX2_22187159_ChIP-Seq_PCA_Human1.00695429
93RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00290477
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00271747
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99188414
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99110781
97STAT3_23295773_ChIP-Seq_U87_Human0.98232732
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97640185
99KLF4_19829295_ChIP-Seq_ESCs_Human0.96993305
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95212108
101PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94679975
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94265505
103SA1_22415368_ChIP-Seq_MEFs_Mouse0.94124097
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.94067573
105RING1B_27294783_Chip-Seq_NPCs_Mouse0.92706392
106ESR2_21235772_ChIP-Seq_MCF-7_Human0.91711912
107TCF4_18268006_ChIP-ChIP_LS174T_Human0.91695065
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91212546
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90071143
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89921652
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89921652
112BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89701833
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89501989
114SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88732102
115EP300_21415370_ChIP-Seq_HL-1_Mouse0.88594218
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88249378
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87385011
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86655430
119TCF4_23295773_ChIP-Seq_U87_Human0.85544009
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85507213
121ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84910989
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84728136
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84605224
124AHR_22903824_ChIP-Seq_MCF-7_Human0.84340630
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.84238754
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.84182960
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84074083
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84074083
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83852317
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83720239
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81803115
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.80995475
133ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80700167
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80513235
135ER_23166858_ChIP-Seq_MCF-7_Human0.79978557
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.78787916
137MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.77643399
138TBX20_22328084_ChIP-Seq_HEART_Mouse0.77608635
139TBX20_22080862_ChIP-Seq_HEART_Mouse0.77608635
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77297452
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77037635
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75234694
143ZNF263_19887448_ChIP-Seq_K562_Human0.74984933
144PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72642015
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.72519701
146GATA1_26923725_Chip-Seq_HPCs_Mouse0.70543720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.02588023
2MP0003690_abnormal_glial_cell3.90135072
3MP0005670_abnormal_white_adipose3.42400335
4MP0002254_reproductive_system_inflammat3.28041895
5MP0009780_abnormal_chondrocyte_physiolo3.15204270
6MP0005423_abnormal_somatic_nervous2.75481492
7MP0005171_absent_coat_pigmentation2.70225224
8MP0002970_abnormal_white_adipose2.66263252
9MP0004885_abnormal_endolymph2.63503670
10MP0001486_abnormal_startle_reflex2.54029262
11MP0003329_amyloid_beta_deposits2.51387164
12MP0004859_abnormal_synaptic_plasticity2.43434103
13MP0005448_abnormal_energy_balance2.32749608
14MP0003959_abnormal_lean_body2.26584366
15MP0000566_synostosis2.20567506
16MP0002638_abnormal_pupillary_reflex2.12727267
17* MP0003635_abnormal_synaptic_transmissio2.12319424
18MP0004270_analgesia2.10480793
19MP0005377_hearing/vestibular/ear_phenot2.04733770
20MP0003878_abnormal_ear_physiology2.04733770
21MP0002118_abnormal_lipid_homeostasis2.02259318
22MP0005646_abnormal_pituitary_gland1.97540622
23MP0001440_abnormal_grooming_behavior1.94694107
24MP0005666_abnormal_adipose_tissue1.93652471
25MP0001501_abnormal_sleep_pattern1.93213670
26MP0004858_abnormal_nervous_system1.92854877
27MP0003880_abnormal_central_pattern1.86042216
28MP0009745_abnormal_behavioral_response1.83880698
29MP0004130_abnormal_muscle_cell1.82598400
30MP0005452_abnormal_adipose_tissue1.79905743
31MP0009384_cardiac_valve_regurgitation1.73572684
32MP0006138_congestive_heart_failure1.73434395
33MP0000003_abnormal_adipose_tissue1.71421619
34MP0002572_abnormal_emotion/affect_behav1.68344388
35* MP0002064_seizures1.59724933
36MP0008569_lethality_at_weaning1.57977562
37MP0002063_abnormal_learning/memory/cond1.57776053
38MP0001502_abnormal_circadian_rhythm1.56134656
39MP0003075_altered_response_to1.53834562
40MP0003634_abnormal_glial_cell1.50946363
41MP0003279_aneurysm1.46390208
42* MP0009046_muscle_twitch1.45973100
43MP0003868_abnormal_feces_composition1.43484135
44MP0002733_abnormal_thermal_nociception1.43098611
45MP0005379_endocrine/exocrine_gland_phen1.41986493
46MP0002078_abnormal_glucose_homeostasis1.40539634
47MP0001485_abnormal_pinna_reflex1.39959207
48MP0005645_abnormal_hypothalamus_physiol1.39836839
49MP0001968_abnormal_touch/_nociception1.39410169
50MP0004215_abnormal_myocardial_fiber1.38545164
51MP0002272_abnormal_nervous_system1.37589388
52MP0000604_amyloidosis1.36956325
53MP0002734_abnormal_mechanical_nocicepti1.35585577
54MP0006276_abnormal_autonomic_nervous1.34424772
55MP0002736_abnormal_nociception_after1.32180608
56MP0002067_abnormal_sensory_capabilities1.31243226
57MP0003186_abnormal_redox_activity1.29801798
58* MP0003633_abnormal_nervous_system1.27083480
59MP0002557_abnormal_social/conspecific_i1.24589428
60MP0003137_abnormal_impulse_conducting1.22494237
61MP0002876_abnormal_thyroid_physiology1.22301121
62MP0005503_abnormal_tendon_morphology1.22041218
63MP0000343_altered_response_to1.21144596
64MP0005375_adipose_tissue_phenotype1.18672539
65MP0003183_abnormal_peptide_metabolism1.18514790
66MP0010329_abnormal_lipoprotein_level1.18405781
67MP0005584_abnormal_enzyme/coenzyme_acti1.17123101
68MP0002971_abnormal_brown_adipose1.16465017
69MP0001986_abnormal_taste_sensitivity1.15353310
70MP0002909_abnormal_adrenal_gland1.14601969
71MP0004924_abnormal_behavior1.13741292
72MP0005386_behavior/neurological_phenoty1.13741292
73MP0005595_abnormal_vascular_smooth1.13623869
74MP0003011_delayed_dark_adaptation1.13424511
75MP0001970_abnormal_pain_threshold1.12237714
76MP0001984_abnormal_olfaction1.11114312
77MP0004142_abnormal_muscle_tone1.10627290
78MP0005551_abnormal_eye_electrophysiolog1.10216644
79MP0009115_abnormal_fat_cell1.09809244
80MP0000013_abnormal_adipose_tissue1.09012556
81MP0002249_abnormal_larynx_morphology1.07645120
82* MP0003631_nervous_system_phenotype1.07021693
83MP0001963_abnormal_hearing_physiology1.06788884
84MP0003828_pulmonary_edema1.05527947
85MP0009379_abnormal_foot_pigmentation1.03806734
86MP0003948_abnormal_gas_homeostasis1.03462456
87MP0006036_abnormal_mitochondrial_physio1.03029420
88MP0004782_abnormal_surfactant_physiolog1.02441229
89MP0005535_abnormal_body_temperature1.01542357
90MP0003646_muscle_fatigue1.00733037
91MP0002653_abnormal_ependyma_morphology1.00512157
92MP0003953_abnormal_hormone_level1.00360896
93MP0009840_abnormal_foam_cell1.00080477
94MP0003632_abnormal_nervous_system0.99908652
95MP0005647_abnormal_sex_gland0.99820911
96MP0003283_abnormal_digestive_organ0.99566347
97MP0004043_abnormal_pH_regulation0.98673267
98MP0001853_heart_inflammation0.97937425
99MP0004185_abnormal_adipocyte_glucose0.97809656
100MP0005167_abnormal_blood-brain_barrier0.97175193
101MP0005365_abnormal_bile_salt0.96339559
102MP0000026_abnormal_inner_ear0.95745249
103MP0002139_abnormal_hepatobiliary_system0.94777094
104MP0001661_extended_life_span0.94399199
105MP0000751_myopathy0.94206537
106MP0000750_abnormal_muscle_regeneration0.94092456
107MP0001905_abnormal_dopamine_level0.92868665
108MP0000778_abnormal_nervous_system0.91639072
109MP0005253_abnormal_eye_physiology0.91394289
110MP0003950_abnormal_plasma_membrane0.91231812
111MP0000049_abnormal_middle_ear0.90421823
112MP0006292_abnormal_olfactory_placode0.89313886
113MP0003724_increased_susceptibility_to0.88947108
114MP0001958_emphysema0.88896796
115MP0003879_abnormal_hair_cell0.88357245
116MP0002089_abnormal_postnatal_growth/wei0.87594666
117MP0000609_abnormal_liver_physiology0.86842419
118MP0001544_abnormal_cardiovascular_syste0.85602899
119MP0005385_cardiovascular_system_phenoty0.85602899
120MP0002069_abnormal_eating/drinking_beha0.85492096
121MP0009672_abnormal_birth_weight0.83740092
122MP0002882_abnormal_neuron_morphology0.82226491
123MP0001944_abnormal_pancreas_morphology0.81947156
124MP0002837_dystrophic_cardiac_calcinosis0.80518836
125* MP0002066_abnormal_motor_capabilities/c0.80418310
126MP0001664_abnormal_digestion0.79746846
127MP0000920_abnormal_myelination0.77905836
128MP0002090_abnormal_vision0.77399130
129MP0004272_abnormal_basement_membrane0.76712314
130MP0001177_atelectasis0.76265570
131MP0002108_abnormal_muscle_morphology0.73721219
132MP0001299_abnormal_eye_distance/0.73139980
133MP0005334_abnormal_fat_pad0.72022579
134MP0001881_abnormal_mammary_gland0.71706393
135MP0004742_abnormal_vestibular_system0.71683900
136MP0002229_neurodegeneration0.71467419
137MP0001764_abnormal_homeostasis0.67689427
138MP0001879_abnormal_lymphatic_vessel0.65140576
139MP0008775_abnormal_heart_ventricle0.61319686
140MP0003122_maternal_imprinting0.59616068
141MP0000230_abnormal_systemic_arterial0.59158997
142MP0002822_catalepsy0.57732654
143MP0001542_abnormal_bone_strength0.54438891
144* MP0005332_abnormal_amino_acid0.54397578
145MP0005388_respiratory_system_phenotype0.51686481
146MP0002133_abnormal_respiratory_system0.51686481
147MP0000249_abnormal_blood_vessel0.51535106
148MP0000759_abnormal_skeletal_muscle0.49601640
149MP0008438_abnormal_cutaneous_collagen0.48295334

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the phalanges of the hand (HP:0009802)7.01986856
2Aplasia involving bones of the extremities (HP:0009825)7.01986856
3Aplasia involving bones of the upper limbs (HP:0009823)7.01986856
4Oligomenorrhea (HP:0000876)6.43992923
5Megalencephaly (HP:0001355)5.61653944
6Neurofibrillary tangles (HP:0002185)4.77351429
7Hemiparesis (HP:0001269)4.66143411
8Abnormality of secondary sexual hair (HP:0009888)4.57264787
9Abnormality of the axillary hair (HP:0100134)4.57264787
10Long foot (HP:0001833)4.46880783
11Diplopia (HP:0000651)4.35831787
12Abnormality of binocular vision (HP:0011514)4.35831787
13Hemiplegia (HP:0002301)4.20592566
14Epidermoid cyst (HP:0200040)4.17442636
15Hypoplastic left heart (HP:0004383)4.16526161
16Bone cyst (HP:0012062)4.04215190
17Prominent supraorbital ridges (HP:0000336)4.00530185
18Growth hormone excess (HP:0000845)3.90599254
19Xanthomatosis (HP:0000991)3.78192273
20Insulin resistance (HP:0000855)3.71888707
21Cerebral inclusion bodies (HP:0100314)3.66632869
22Humeroradial synostosis (HP:0003041)3.55212517
23Synostosis involving the elbow (HP:0003938)3.55212517
24Nausea (HP:0002018)3.52890223
25Insulin-resistant diabetes mellitus (HP:0000831)3.38189048
26Increased serum pyruvate (HP:0003542)3.34978543
27Pigmentary retinal degeneration (HP:0001146)3.31314222
28Mixed hearing impairment (HP:0000410)3.28636043
29Focal motor seizures (HP:0011153)3.21307377
30Increased muscle lipid content (HP:0009058)3.20658956
31Hyperalaninemia (HP:0003348)3.19727589
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.19727589
33Abnormality of alanine metabolism (HP:0010916)3.19727589
34Hypercholesterolemia (HP:0003124)3.15510349
35Tetraparesis (HP:0002273)3.14291319
36Hypoplastic heart (HP:0001961)3.11960675
37Clumsiness (HP:0002312)3.10284828
38Onycholysis (HP:0001806)3.09042017
39Axonal loss (HP:0003447)3.04358372
40Difficulty running (HP:0009046)2.99756920
41Skin nodule (HP:0200036)2.95642343
42Hyperglycinuria (HP:0003108)2.91036423
43Myocardial infarction (HP:0001658)2.86157387
44Mesangial abnormality (HP:0001966)2.85986583
45Back pain (HP:0003418)2.76675047
46Hypoalphalipoproteinemia (HP:0003233)2.76324288
47Epileptic encephalopathy (HP:0200134)2.76267545
48Split foot (HP:0001839)2.76200425
49Narrow nasal bridge (HP:0000446)2.75804920
50Increased variability in muscle fiber diameter (HP:0003557)2.73068106
51Absent hair (HP:0002298)2.71999617
52Large for gestational age (HP:0001520)2.68757207
53Abnormality of glycolysis (HP:0004366)2.66314121
54Myoglobinuria (HP:0002913)2.64273628
55Long nose (HP:0003189)2.63400792
56Hemorrhage of the eye (HP:0011885)2.61348755
57Abnormality of fatty-acid metabolism (HP:0004359)2.60434644
58Short middle phalanx of the 5th finger (HP:0004220)2.59088607
59Rhabdomyolysis (HP:0003201)2.56705395
60Protrusio acetabuli (HP:0003179)2.56270365
61Abnormality of the dental pulp (HP:0006479)2.55479881
62Abnormality of glycine metabolism (HP:0010895)2.53502784
63Abnormality of serine family amino acid metabolism (HP:0010894)2.53502784
64Confusion (HP:0001289)2.51076798
65Abnormal eating behavior (HP:0100738)2.49609728
66Accelerated skeletal maturation (HP:0005616)2.46922522
67Supranuclear gaze palsy (HP:0000605)2.44532482
68Complement deficiency (HP:0004431)2.42795297
69Maternal diabetes (HP:0009800)2.41196103
70Infantile muscular hypotonia (HP:0008947)2.40280290
71Broad metatarsal (HP:0001783)2.39867554
72Short hallux (HP:0010109)2.39840144
73Bronchomalacia (HP:0002780)2.39254009
74Abnormal hemoglobin (HP:0011902)2.38671873
75Broad alveolar ridges (HP:0000187)2.38155923
76Status epilepticus (HP:0002133)2.34848723
77Paraparesis (HP:0002385)2.34523656
78Fibular aplasia (HP:0002990)2.34155589
79Impulsivity (HP:0100710)2.30413026
80Pseudobulbar signs (HP:0002200)2.29077652
81White forelock (HP:0002211)2.28646607
82Amyloidosis (HP:0011034)2.26755334
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.26454636
84Ectopia lentis (HP:0001083)2.26195927
85Hyperlipoproteinemia (HP:0010980)2.25933507
86Oligodactyly (hands) (HP:0001180)2.22228168
87Hypoglycemic coma (HP:0001325)2.21945913
88Acanthosis nigricans (HP:0000956)2.21108494
89Pulmonary artery stenosis (HP:0004415)2.20140299
90Large hands (HP:0001176)2.20054552
91Osteomalacia (HP:0002749)2.19120019
92Abnormality of the middle phalanges of the toes (HP:0010183)2.18801372
93Adactyly (HP:0009776)2.17112833
94Hypercortisolism (HP:0001578)2.16593821
95Focal seizures (HP:0007359)2.15729290
96Nasolacrimal duct obstruction (HP:0000579)2.14573764
97Abnormality of molar (HP:0011077)2.12702366
98Abnormality of molar morphology (HP:0011070)2.12702366
99Neonatal onset (HP:0003623)2.12654950
100Aplasia/Hypoplasia of the hallux (HP:0008362)2.11789248
101Generalized tonic-clonic seizures (HP:0002069)2.11777018
102Partial duplication of thumb phalanx (HP:0009944)2.11520019
103Abnormality of nail color (HP:0100643)2.06588227
104Dynein arm defect of respiratory motile cilia (HP:0012255)2.06247423
105Absent/shortened dynein arms (HP:0200106)2.06247423
106Neonatal short-limb short stature (HP:0008921)2.05710256
107Hypertriglyceridemia (HP:0002155)2.05128248
108Ileus (HP:0002595)2.05037333
109Taurodontia (HP:0000679)2.05033407
110Abnormality of permanent molar morphology (HP:0011071)2.05033407
111Abnormality of the dental root (HP:0006486)2.05033407
112Polyphagia (HP:0002591)2.04692948
113Patchy hypopigmentation of hair (HP:0011365)2.04219560
114Action tremor (HP:0002345)2.04014609
115Opisthotonus (HP:0002179)2.03872787
116Turricephaly (HP:0000262)2.03835344
117Subcapsular cataract (HP:0000523)1.98569330
118Facial shape deformation (HP:0011334)1.96470060
119Potter facies (HP:0002009)1.96470060
120Craniofacial hyperostosis (HP:0004493)1.96108512
121Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.94198410
122Easy fatigability (HP:0003388)1.93888708
123Mutism (HP:0002300)1.93559392
124Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93096037
125Dicarboxylic aciduria (HP:0003215)1.93096037
126Multifactorial inheritance (HP:0001426)1.91783232
127Abnormality of the lacrimal duct (HP:0011481)1.90944406
128Abnormality of skeletal muscle fiber size (HP:0012084)1.90542000
129Retinal atrophy (HP:0001105)1.89583855
130Renal tubular acidosis (HP:0001947)1.88922239
131Dysdiadochokinesis (HP:0002075)1.88586066
132Myokymia (HP:0002411)1.87564030
133Progressive cerebellar ataxia (HP:0002073)1.87041626
134Aplasia/Hypoplasia of the fibula (HP:0006492)1.86234453
135Vascular tortuosity (HP:0004948)1.85527356
136Rickets (HP:0002748)1.85357333
137Inability to walk (HP:0002540)1.84740603
138Gowers sign (HP:0003391)1.83795735
139Partial duplication of the phalanx of hand (HP:0009999)1.83727508
140Coronal craniosynostosis (HP:0004440)1.83026808
141Spastic paraparesis (HP:0002313)1.83005888
142Abnormality of hair growth rate (HP:0011363)1.82681044
143Slow-growing hair (HP:0002217)1.82681044
144Polar cataract (HP:0010696)1.82460610
145Polygenic inheritance (HP:0010982)1.80996671
146Sprengel anomaly (HP:0000912)1.79386397
147Abnormality of the periventricular white matter (HP:0002518)1.79325453
148Arterial tortuosity (HP:0005116)1.78858632
149Abnormality of the labia (HP:0000058)1.77126502
150Hypoplastic pelvis (HP:0008839)1.76708153
151Alacrima (HP:0000522)1.74464334
152Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.74196435
153Limb dystonia (HP:0002451)1.74139660
154Vertebral compression fractures (HP:0002953)1.73839254
155Impaired social interactions (HP:0000735)1.73529940
156Abnormal social behavior (HP:0012433)1.73529940
157Postural instability (HP:0002172)1.73172663
158Prenatal maternal abnormality (HP:0002686)1.72228757
159Abnormality of the nasolacrimal system (HP:0000614)1.71983029
160Cranial hyperostosis (HP:0004437)1.70474026
161Absent toe (HP:0010760)1.69420027
162Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.69068611
163Megalocornea (HP:0000485)1.68885359
164Thyroid-stimulating hormone excess (HP:0002925)1.68289411
165Soft skin (HP:0000977)1.67134180
166Thickened helices (HP:0000391)1.67067433
167Polycythemia (HP:0001901)1.66999740
168Dry hair (HP:0011359)1.66644301
169Abnormality of the diencephalon (HP:0010662)1.66381686
170Spastic tetraparesis (HP:0001285)1.66358527
171Atonic seizures (HP:0010819)1.66218417
172Hydroxyprolinuria (HP:0003080)1.65892221
173Abnormality of proline metabolism (HP:0010907)1.65892221
174Tetraplegia (HP:0002445)1.65501034
175Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.65153407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.76155954
2TNIK4.55066619
3LMTK24.40824180
4PHKG23.73976019
5PHKG13.73976019
6PRKD33.35739862
7MAPK153.29076874
8NTRK22.60956160
9SIK12.46956899
10PNCK2.41775104
11CASK2.27161042
12CAMK1D2.20618984
13NTRK31.99655264
14CAMK1G1.98567204
15LATS21.87751067
16TRIB31.83406440
17MAPK131.80387893
18MUSK1.80363620
19MAP3K131.79783075
20BMPR1B1.72061067
21CAMKK11.69472867
22TIE11.63949635
23MAPK41.63758435
24MAPK121.56883645
25INSRR1.51516902
26IRAK31.50573183
27ABL21.48378425
28MINK11.42789157
29TNK21.41867730
30TGFBR21.40176608
31MKNK21.36782314
32MAP2K71.35054819
33SGK21.31920236
34WNK41.30588987
35MAP3K111.26611126
36MARK11.19650568
37PIK3CA1.19324136
38SGK2231.18799075
39SGK4941.18799075
40PRKAA21.16450292
41MAP3K41.11788928
42FGFR21.08344479
43MAP2K11.06336143
44SGK31.05811798
45GRK11.04378885
46DYRK21.02857933
47GSK3A1.02096293
48EPHA30.98545864
49TSSK60.97945806
50PRKD20.97541727
51NEK60.96925603
52CDK30.96892371
53TESK10.96525908
54BLK0.96210079
55PRKCG0.94921800
56PRKCE0.89984620
57FGR0.87227024
58DDR20.85964692
59CDK60.84603820
60CDK50.84065116
61PRKCH0.83712900
62DYRK1A0.80870835
63RIPK10.80311769
64PINK10.80039314
65FES0.79752613
66PAK60.79091633
67MYLK0.77041967
68FGFR30.76137152
69CAMK40.74197051
70ADRBK10.74194034
71AKT30.72507230
72NLK0.71815108
73MAPK70.70471463
74MAP3K70.69994916
75MAP2K40.67038419
76PDK30.66575047
77PDK40.66575047
78STK110.65988247
79CDC42BPA0.65285202
80CAMK2A0.64242236
81CDK90.63696519
82NTRK10.63053109
83WNK30.62749590
84CAMK10.61725678
85MAPKAPK50.61236611
86PKN20.60971618
87PDGFRB0.60589732
88ARAF0.60570785
89SGK10.60305269
90ROCK10.60048630
91PDPK10.58838285
92IGF1R0.58133083
93STK380.57889295
94ILK0.57048882
95PKN10.55241666
96DAPK30.55240431
97DYRK30.52549306
98TYRO30.51124979
99PRKACG0.48845188
100FLT30.48322815
101PAK30.48022838
102PDGFRA0.47814993
103FGFR10.46885574
104MAP2K20.46747272
105GRK50.46102555
106PRKACA0.46056739
107RIPK40.46003366
108PRKCA0.45893023
109JAK20.45862865
110DAPK20.44692732
111MAPK30.44017496
112DMPK0.43808849
113PRKACB0.43577209
114PRKAA10.43408172
115ROCK20.43270559
116SRC0.43187151
117BMX0.42951512
118PRKD10.42198177
119PRKCQ0.41966535
120ERN10.41835806
121MAP3K90.41590965
122ADRBK20.41551611
123RPS6KA30.41346103
124ICK0.41002199
125PAK20.40871384
126MAP3K60.40664126
127WNK10.40643045
128CAMK2G0.40175879
129BCKDK0.39726231
130PRPF4B0.39227295
131PRKG10.38536558
132RPS6KA60.38226209
133PDK10.38048575
134AKT20.37162547
135CDK40.36172598
136CDK80.35479204
137EPHB20.35350798
138IRAK10.34960686
139AKT10.34730219
140RPS6KA20.33878228
141SIK20.33172741
142ERBB40.33125936
143PRKCZ0.32958383
144FER0.32762732
145FYN0.32442621
146CAMKK20.30539298
147MARK20.30257584

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.81284411
2Nitrogen metabolism_Homo sapiens_hsa009104.17453329
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.59928298
4Fatty acid metabolism_Homo sapiens_hsa012122.84411360
5Phenylalanine metabolism_Homo sapiens_hsa003602.71857806
6Nicotine addiction_Homo sapiens_hsa050332.65228594
7PPAR signaling pathway_Homo sapiens_hsa033202.35372416
8Sulfur relay system_Homo sapiens_hsa041222.24938583
9Fatty acid degradation_Homo sapiens_hsa000712.24038026
10Fat digestion and absorption_Homo sapiens_hsa049752.12794402
11GABAergic synapse_Homo sapiens_hsa047271.88765868
12Salivary secretion_Homo sapiens_hsa049701.86523246
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.82800335
14Propanoate metabolism_Homo sapiens_hsa006401.77623296
15Glutamatergic synapse_Homo sapiens_hsa047241.70381473
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.69963998
17Tyrosine metabolism_Homo sapiens_hsa003501.66543492
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.62618266
19Gastric acid secretion_Homo sapiens_hsa049711.50231741
20Morphine addiction_Homo sapiens_hsa050321.49064092
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48916574
22Histidine metabolism_Homo sapiens_hsa003401.38046871
23Glycerolipid metabolism_Homo sapiens_hsa005611.33551971
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33083951
25Tryptophan metabolism_Homo sapiens_hsa003801.32671446
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.31815412
27Insulin secretion_Homo sapiens_hsa049111.30194277
28Circadian entrainment_Homo sapiens_hsa047131.29147984
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25086046
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24972164
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23138398
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21582880
33Steroid biosynthesis_Homo sapiens_hsa001001.19846940
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19065487
35Renin secretion_Homo sapiens_hsa049241.18112070
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15706825
37Calcium signaling pathway_Homo sapiens_hsa040201.15157878
38Bile secretion_Homo sapiens_hsa049761.12309067
39Olfactory transduction_Homo sapiens_hsa047401.03795170
40Cocaine addiction_Homo sapiens_hsa050301.00266704
41cAMP signaling pathway_Homo sapiens_hsa040240.98476905
42Long-term potentiation_Homo sapiens_hsa047200.97894481
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97755957
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97528339
45Taste transduction_Homo sapiens_hsa047420.97494970
46Fatty acid elongation_Homo sapiens_hsa000620.97160901
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96220308
48Ovarian steroidogenesis_Homo sapiens_hsa049130.95515484
49Folate biosynthesis_Homo sapiens_hsa007900.94268621
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91783509
51Peroxisome_Homo sapiens_hsa041460.90744496
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90505532
53Mineral absorption_Homo sapiens_hsa049780.88316318
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.85082468
55Pancreatic secretion_Homo sapiens_hsa049720.84025333
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83299290
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81846704
58Circadian rhythm_Homo sapiens_hsa047100.81088245
59beta-Alanine metabolism_Homo sapiens_hsa004100.80426433
60Melanogenesis_Homo sapiens_hsa049160.80372831
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77886427
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77332508
63Amphetamine addiction_Homo sapiens_hsa050310.75658377
64Long-term depression_Homo sapiens_hsa047300.74503122
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73777333
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71309802
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69626341
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69070250
69Butanoate metabolism_Homo sapiens_hsa006500.68917776
70Serotonergic synapse_Homo sapiens_hsa047260.67528021
71Basal cell carcinoma_Homo sapiens_hsa052170.67513013
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65101901
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.64132996
74Dorso-ventral axis formation_Homo sapiens_hsa043200.63262287
75Thyroid hormone synthesis_Homo sapiens_hsa049180.62987173
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62860324
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59452460
78Cholinergic synapse_Homo sapiens_hsa047250.58749855
79Glucagon signaling pathway_Homo sapiens_hsa049220.57892740
80Sulfur metabolism_Homo sapiens_hsa009200.57753774
81Synaptic vesicle cycle_Homo sapiens_hsa047210.57252135
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56460944
83Vitamin B6 metabolism_Homo sapiens_hsa007500.55747737
84Gap junction_Homo sapiens_hsa045400.55560045
85Dopaminergic synapse_Homo sapiens_hsa047280.52729389
86Pyruvate metabolism_Homo sapiens_hsa006200.52636238
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52567572
88Cardiac muscle contraction_Homo sapiens_hsa042600.51449556
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48567351
90Dilated cardiomyopathy_Homo sapiens_hsa054140.47280815
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47205958
92Retinol metabolism_Homo sapiens_hsa008300.46884341
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46865507
94Type II diabetes mellitus_Homo sapiens_hsa049300.46794529
95Fructose and mannose metabolism_Homo sapiens_hsa000510.46743680
96Oxytocin signaling pathway_Homo sapiens_hsa049210.46724909
97Vitamin digestion and absorption_Homo sapiens_hsa049770.46163173
98Insulin signaling pathway_Homo sapiens_hsa049100.45688196
99Ether lipid metabolism_Homo sapiens_hsa005650.45444292
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44989711
101African trypanosomiasis_Homo sapiens_hsa051430.44428368
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42958538
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42413535
104Sphingolipid metabolism_Homo sapiens_hsa006000.42292653
105Arginine biosynthesis_Homo sapiens_hsa002200.41318474
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.41258110
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40746750
108Arginine and proline metabolism_Homo sapiens_hsa003300.40675715
109AMPK signaling pathway_Homo sapiens_hsa041520.40164663
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39777623
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.39776406
112ABC transporters_Homo sapiens_hsa020100.39148167
113Insulin resistance_Homo sapiens_hsa049310.39064647
114Caffeine metabolism_Homo sapiens_hsa002320.38910796
115Protein digestion and absorption_Homo sapiens_hsa049740.37553794
116Glutathione metabolism_Homo sapiens_hsa004800.37467128
117Rap1 signaling pathway_Homo sapiens_hsa040150.37262609
118Axon guidance_Homo sapiens_hsa043600.36871166
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36589761
120ECM-receptor interaction_Homo sapiens_hsa045120.36350189
121Carbon metabolism_Homo sapiens_hsa012000.34911639
122Choline metabolism in cancer_Homo sapiens_hsa052310.34435824
123Renin-angiotensin system_Homo sapiens_hsa046140.33093619
124GnRH signaling pathway_Homo sapiens_hsa049120.32228447
125Hedgehog signaling pathway_Homo sapiens_hsa043400.30577177
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30027356
127Notch signaling pathway_Homo sapiens_hsa043300.28529676
128Alzheimers disease_Homo sapiens_hsa050100.27418206
129Estrogen signaling pathway_Homo sapiens_hsa049150.27339267
130Parkinsons disease_Homo sapiens_hsa050120.22247381
131Metabolic pathways_Homo sapiens_hsa011000.20356756
132Oxidative phosphorylation_Homo sapiens_hsa001900.20351794
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19919800

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