SLC6A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.19712805
2virion attachment to host cell (GO:0019062)4.70112931
3adhesion of symbiont to host cell (GO:0044650)4.70112931
4very-low-density lipoprotein particle assembly (GO:0034379)4.70058483
5plasma membrane repair (GO:0001778)4.62194970
6regulation of cardioblast differentiation (GO:0051890)4.60134388
7labyrinthine layer development (GO:0060711)4.56675469
8intestinal epithelial cell development (GO:0060576)4.45842989
9proline biosynthetic process (GO:0006561)4.35910109
10negative regulation of potassium ion transmembrane transport (GO:1901380)4.34121316
11bundle of His cell to Purkinje myocyte communication (GO:0086069)4.32398544
12ventricular cardiac muscle cell action potential (GO:0086005)4.12497311
13glucose 6-phosphate metabolic process (GO:0051156)4.08139631
14plasma lipoprotein particle assembly (GO:0034377)4.08031169
15protein-lipid complex assembly (GO:0065005)4.05052717
16sarcomere organization (GO:0045214)4.02207480
17regulation of cholesterol homeostasis (GO:2000188)3.84088939
18hemidesmosome assembly (GO:0031581)3.74610421
19proline metabolic process (GO:0006560)3.74356451
20desmosome organization (GO:0002934)3.73847351
21fructose metabolic process (GO:0006000)3.67780053
22cell communication involved in cardiac conduction (GO:0086065)3.59446949
23anterior/posterior axis specification, embryo (GO:0008595)3.58014345
24planar cell polarity pathway involved in neural tube closure (GO:0090179)3.57658486
25protein localization to endosome (GO:0036010)3.55149543
26cytoskeletal anchoring at plasma membrane (GO:0007016)3.53832551
27actin filament depolymerization (GO:0030042)3.53724616
28regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.51887186
29adhesion of symbiont to host (GO:0044406)3.51718926
30sodium ion export (GO:0071436)3.50559518
31regulation of cholesterol biosynthetic process (GO:0045540)3.42849724
32epithelial cell-cell adhesion (GO:0090136)3.42542550
33regulation of early endosome to late endosome transport (GO:2000641)3.38120420
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35446193
35cardiac myofibril assembly (GO:0055003)3.33255663
36angiotensin maturation (GO:0002003)3.23619243
37CDP-diacylglycerol metabolic process (GO:0046341)3.23503264
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22032285
39regulation of bile acid biosynthetic process (GO:0070857)3.21611901
40positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.20822736
41protein retention in ER lumen (GO:0006621)3.20338142
42interferon-gamma secretion (GO:0072643)3.16948554
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16222533
444-hydroxyproline metabolic process (GO:0019471)3.15269605
45positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.07761925
46actomyosin structure organization (GO:0031032)3.06130371
47regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.04205242
48cardiac muscle cell development (GO:0055013)3.02725683
49positive regulation of synapse maturation (GO:0090129)2.97808075
50muscle filament sliding (GO:0030049)2.95525726
51actin-myosin filament sliding (GO:0033275)2.95525726
52convergent extension (GO:0060026)2.94944260
53regulation of cholesterol metabolic process (GO:0090181)2.93933338
54NADH metabolic process (GO:0006734)2.92698867
55receptor guanylyl cyclase signaling pathway (GO:0007168)2.92320941
56regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.91242068
57cell-cell junction maintenance (GO:0045217)2.91097809
58regulation of skeletal muscle contraction (GO:0014819)2.89743504
59cell communication by electrical coupling (GO:0010644)2.89730259
60myofibril assembly (GO:0030239)2.89456072
61regulation of translational fidelity (GO:0006450)2.88842603
62glutamine family amino acid biosynthetic process (GO:0009084)2.87218513
63positive regulation of sodium ion transport (GO:0010765)2.86047580
64negative regulation of protein localization to cell surface (GO:2000009)2.85284759
65oxaloacetate metabolic process (GO:0006107)2.83058721
66ectoderm development (GO:0007398)2.82938956
67cellular potassium ion homeostasis (GO:0030007)2.81759070
68* modified amino acid transport (GO:0072337)2.79796403
69cell junction maintenance (GO:0034331)2.78996801
70gluconeogenesis (GO:0006094)2.77817209
71cardiac cell development (GO:0055006)2.77741004
72vitamin A metabolic process (GO:0006776)2.77482783
73intestinal absorption (GO:0050892)2.77182644
74cardiac muscle cell action potential involved in contraction (GO:0086002)2.76505851
75layer formation in cerebral cortex (GO:0021819)2.75976468
76CDP-diacylglycerol biosynthetic process (GO:0016024)2.74079361
77regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.73647781
78axon ensheathment in central nervous system (GO:0032291)2.73106683
79central nervous system myelination (GO:0022010)2.73106683
80tricarboxylic acid cycle (GO:0006099)2.71720857
81actin-mediated cell contraction (GO:0070252)2.71346937
82cardiac muscle contraction (GO:0060048)2.71126596
83regulation of water loss via skin (GO:0033561)2.70790112
84glycolytic process (GO:0006096)2.69636219
85heterochromatin organization (GO:0070828)2.68288988
86cardiac muscle cell action potential (GO:0086001)2.67968175
87positive regulation of sodium ion transmembrane transport (GO:1902307)2.67031623
88regulation of hippo signaling (GO:0035330)2.66518371
89homocysteine metabolic process (GO:0050667)2.65459710
90stress fiber assembly (GO:0043149)2.64297714
91hexose biosynthetic process (GO:0019319)2.64188639
92cellular sodium ion homeostasis (GO:0006883)2.61975256
93lung-associated mesenchyme development (GO:0060484)2.61153733
94regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.60267380
95diacylglycerol metabolic process (GO:0046339)2.59858360
96potassium ion homeostasis (GO:0055075)2.59348420
97potassium ion import (GO:0010107)2.58603504
98regulation of tight junction assembly (GO:2000810)2.58559375
99cell-substrate junction assembly (GO:0007044)2.58540253
100protein-lipid complex subunit organization (GO:0071825)2.58435012
101protoporphyrinogen IX metabolic process (GO:0046501)2.58304545
102low-density lipoprotein particle clearance (GO:0034383)2.57099845
103lipoprotein transport (GO:0042953)2.56038614
104regulation of actin filament-based movement (GO:1903115)2.55098504
105regulation of phospholipid biosynthetic process (GO:0071071)2.54304960
106Golgi transport vesicle coating (GO:0048200)2.54086125
107COPI coating of Golgi vesicle (GO:0048205)2.54086125
108L-amino acid import (GO:0043092)2.53704179
109regulation of clathrin-mediated endocytosis (GO:2000369)2.53118345
110cardiac conduction (GO:0061337)2.52931475
111establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.52839230
112adherens junction assembly (GO:0034333)2.52269547
113retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51189402
114plasma lipoprotein particle organization (GO:0071827)2.50513071
115folic acid transport (GO:0015884)2.50283413
116monosaccharide biosynthetic process (GO:0046364)2.49721355
117endocytic recycling (GO:0032456)2.49622573
118peptidyl-proline hydroxylation (GO:0019511)2.48696202
119membrane tubulation (GO:0097320)2.47796920
120trophectodermal cell differentiation (GO:0001829)2.47310341
121regulation of heart rate by cardiac conduction (GO:0086091)2.46915942
122actin filament-based movement (GO:0030048)2.46635936
123establishment or maintenance of bipolar cell polarity (GO:0061245)2.45469620
124establishment or maintenance of apical/basal cell polarity (GO:0035088)2.45469620
125heart trabecula formation (GO:0060347)2.45281572
126regulation of p38MAPK cascade (GO:1900744)2.44860585
127nucleoside diphosphate biosynthetic process (GO:0009133)2.44329481
128apoptotic process involved in morphogenesis (GO:0060561)2.44018175
129axon ensheathment (GO:0008366)2.41791863
130ensheathment of neurons (GO:0007272)2.41791863
131negative regulation of nucleotide catabolic process (GO:0030812)2.41698905
132regulation of RNA export from nucleus (GO:0046831)2.41087310
133cochlea morphogenesis (GO:0090103)2.40325068
134membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.39853483
135cell-substrate adherens junction assembly (GO:0007045)2.39643271
136focal adhesion assembly (GO:0048041)2.39643271
137negative regulation of catenin import into nucleus (GO:0035414)2.39309205
138sexual reproduction (GO:0019953)2.37594955
139growth hormone secretion (GO:0030252)2.37110936
140paraxial mesoderm development (GO:0048339)2.37092929
141regulation of sodium ion transmembrane transporter activity (GO:2000649)2.36673861
142negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.36536711
143regulation of sodium ion transmembrane transport (GO:1902305)2.36520058
144cellular response to epidermal growth factor stimulus (GO:0071364)2.36491236
145regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.36233816
146regulation of sodium ion transport (GO:0002028)2.36109941
147lung epithelium development (GO:0060428)2.35184187
148ribosomal small subunit biogenesis (GO:0042274)2.34722231
149peripheral nervous system axon ensheathment (GO:0032292)2.34376392
150myelination in peripheral nervous system (GO:0022011)2.34376392
151Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.34153222
152negative regulation of fatty acid biosynthetic process (GO:0045717)2.33913302
153regulation of nucleobase-containing compound transport (GO:0032239)2.33230152
154regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.32920025
155cerebellar granule cell differentiation (GO:0021707)2.32721691
156response to epidermal growth factor (GO:0070849)2.31927349
157sphingomyelin metabolic process (GO:0006684)2.31385348
158regulation of guanylate cyclase activity (GO:0031282)2.30832970
159labyrinthine layer blood vessel development (GO:0060716)2.30714015
160basement membrane organization (GO:0071711)2.29927450
161regulation of G0 to G1 transition (GO:0070316)2.29481395
162regulation of cholesterol esterification (GO:0010872)2.29232523
163neural tube development (GO:0021915)2.28153584
164viral transcription (GO:0019083)2.27844022
165regulation of response to osmotic stress (GO:0047484)2.26778145
166drinking behavior (GO:0042756)2.26607489
167midgut development (GO:0007494)2.26335179
168regulation of mitotic spindle organization (GO:0060236)2.24651951
169cellular protein complex localization (GO:0034629)2.23933652
170tricarboxylic acid metabolic process (GO:0072350)2.23548867
171positive regulation of dendritic spine morphogenesis (GO:0061003)2.23045195
172regulation of mammary gland epithelial cell proliferation (GO:0033599)2.22589234
173mitotic chromosome condensation (GO:0007076)2.21536655
174RNA stabilization (GO:0043489)2.21275627
175mRNA stabilization (GO:0048255)2.21275627
176DNA unwinding involved in DNA replication (GO:0006268)2.20863915
177cell migration in hindbrain (GO:0021535)2.20043059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.30595905
2ZNF263_19887448_ChIP-Seq_K562_Human3.10941461
3ESR2_21235772_ChIP-Seq_MCF-7_Human2.82258856
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.78913015
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.64127165
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.56577609
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.51661466
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20688497
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19111848
10RACK7_27058665_Chip-Seq_MCF-7_Human1.98338908
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94756010
12* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.92247481
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89617153
14CDX2_20551321_ChIP-Seq_CACO-2_Human1.88607580
15SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.86362507
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83268332
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.75762823
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75337760
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74885066
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68428851
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68428851
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68428851
23ATF3_27146783_Chip-Seq_COLON_Human1.67455379
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.66717313
25* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65886894
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.65213505
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61822332
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.60119430
29SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58869305
30KDM2B_26808549_Chip-Seq_K562_Human1.58512029
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58387913
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57924468
33* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.57829211
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57149221
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56796013
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.56764563
37* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54988793
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.53918118
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.51339079
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50681745
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50048824
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.49955217
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49848703
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49692010
45E2F7_22180533_ChIP-Seq_HELA_Human1.48974604
46P68_20966046_ChIP-Seq_HELA_Human1.48859897
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48723829
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48418811
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46443799
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.45604496
51* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44381943
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.42370825
53LXR_22292898_ChIP-Seq_THP-1_Human1.42036783
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41547970
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41304436
56NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40733255
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.39328836
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.39145501
59AR_21909140_ChIP-Seq_LNCAP_Human1.38739978
60* NCOR1_26117541_ChIP-Seq_K562_Human1.38712510
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37786256
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36657843
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36250714
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35397488
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34729646
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33749557
67RXR_22158963_ChIP-Seq_LIVER_Mouse1.33494209
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33390900
69KLF5_25053715_ChIP-Seq_YYC3_Human1.33273877
70CREB1_26743006_Chip-Seq_LNCaP_Human1.31995981
71* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31721937
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31388709
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30559745
74MYC_22102868_ChIP-Seq_BL_Human1.29415140
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28801384
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28091566
77TCF7_22412390_ChIP-Seq_EML_Mouse1.27962307
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.27702634
79* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27585947
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27088719
81PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27053366
82DROSHA_22980978_ChIP-Seq_HELA_Human1.25764310
83XRN2_22483619_ChIP-Seq_HELA_Human1.25528910
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.24932841
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.24446336
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.24342779
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.24342779
88VDR_21846776_ChIP-Seq_THP-1_Human1.23994434
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23536476
90TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22840578
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22744634
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22737699
93GATA6_25053715_ChIP-Seq_YYC3_Human1.22609048
94NANOG_18692474_ChIP-Seq_MEFs_Mouse1.20581016
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19837630
96TP63_22573176_ChIP-Seq_HFKS_Human1.19743015
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18410742
98MYC_18555785_ChIP-Seq_MESCs_Mouse1.18331590
99NANOG_18692474_ChIP-Seq_MESCs_Mouse1.18069677
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16926690
101SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16921344
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16448830
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16349135
104KDM2B_26808549_Chip-Seq_DND41_Human1.15791924
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14997159
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14892055
107GATA1_19941826_ChIP-Seq_K562_Human1.13167937
108SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12842684
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12556509
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12230513
111STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.11545216
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11468168
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11444755
114HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11316769
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11015976
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10471970
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10020850
118GATA4_25053715_ChIP-Seq_YYC3_Human1.09860361
119ESR1_20079471_ChIP-ChIP_T-47D_Human1.08043348
120PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06853686
121RARA_24833708_ChIP-Seq_LIVER_Mouse1.06779058
122* SOX2_20726797_ChIP-Seq_SW620_Human1.06770543
123CLOCK_20551151_ChIP-Seq_293T_Human1.06291759
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06073977
125CTCF_27219007_Chip-Seq_Bcells_Human1.06069948
126SMAD3_21741376_ChIP-Seq_HESCs_Human1.06018667
127SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05702911
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05492854
129NANOG_21062744_ChIP-ChIP_HESCs_Human1.03443121
130TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03218173
131RARB_27405468_Chip-Seq_BRAIN_Mouse1.02547471
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01625837
133P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01560291
134SA1_27219007_Chip-Seq_Bcells_Human1.01183043
135SMC4_20622854_ChIP-Seq_HELA_Human1.00262105
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99491284
137OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99278500
138RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98943682
139THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98656740
140DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98505777
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97842832
142TP53_22127205_ChIP-Seq_IMR90_Human0.97501080
143ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97461522
144POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97405257
145KDM2B_26808549_Chip-Seq_JURKAT_Human0.97401298
146OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94886813
147AHR_22903824_ChIP-Seq_MCF-7_Human0.94463348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.58254444
2MP0000751_myopathy3.31641226
3MP0009379_abnormal_foot_pigmentation3.13194752
4MP0004084_abnormal_cardiac_muscle3.07377213
5MP0003123_paternal_imprinting3.06468014
6MP0003705_abnormal_hypodermis_morpholog3.05517773
7MP0010234_abnormal_vibrissa_follicle2.91586896
8MP0005409_darkened_coat_color2.65178562
9MP0000678_abnormal_parathyroid_gland2.63839254
10MP0009840_abnormal_foam_cell2.60855503
11MP0002837_dystrophic_cardiac_calcinosis2.51435322
12MP0003646_muscle_fatigue2.51017725
13MP0004215_abnormal_myocardial_fiber2.24860586
14MP0005330_cardiomyopathy2.18232765
15MP0005623_abnormal_meninges_morphology2.17165952
16MP0000749_muscle_degeneration2.14994765
17MP0002796_impaired_skin_barrier2.10902556
18MP0004036_abnormal_muscle_relaxation2.10173203
19MP0000747_muscle_weakness2.10148501
20MP0004147_increased_porphyrin_level2.09899984
21MP0000750_abnormal_muscle_regeneration2.04269671
22MP0003950_abnormal_plasma_membrane2.03130678
23MP0002249_abnormal_larynx_morphology2.01116977
24MP0004087_abnormal_muscle_fiber1.98163179
25MP0003122_maternal_imprinting1.88493846
26MP0004858_abnormal_nervous_system1.84163814
27MP0010352_gastrointestinal_tract_polyps1.78618353
28MP0004484_altered_response_of1.78220279
29MP0004185_abnormal_adipocyte_glucose1.77451705
30MP0004043_abnormal_pH_regulation1.77083743
31MP0000537_abnormal_urethra_morphology1.73192771
32MP0004233_abnormal_muscle_weight1.67740763
33MP0002269_muscular_atrophy1.64049742
34MP0000462_abnormal_digestive_system1.62118715
35MP0005670_abnormal_white_adipose1.59272657
36MP0005275_abnormal_skin_tensile1.59063380
37MP0006138_congestive_heart_failure1.58016203
38MP0010678_abnormal_skin_adnexa1.56975035
39MP0003566_abnormal_cell_adhesion1.55317507
40MP0005377_hearing/vestibular/ear_phenot1.53711974
41MP0003878_abnormal_ear_physiology1.53711974
42MP0004145_abnormal_muscle_electrophysio1.51320538
43MP0005058_abnormal_lysosome_morphology1.50529384
44MP0001849_ear_inflammation1.50405621
45MP0008438_abnormal_cutaneous_collagen1.48762202
46MP0005423_abnormal_somatic_nervous1.48502633
47MP0005076_abnormal_cell_differentiation1.48343958
48MP0003879_abnormal_hair_cell1.48240379
49MP0002972_abnormal_cardiac_muscle1.44901555
50MP0008775_abnormal_heart_ventricle1.44759451
51MP0005620_abnormal_muscle_contractility1.44528415
52MP0005257_abnormal_intraocular_pressure1.41704151
53MP0003137_abnormal_impulse_conducting1.41636895
54MP0000733_abnormal_muscle_development1.41417278
55MP0003136_yellow_coat_color1.41347575
56MP0004270_analgesia1.40563880
57MP0002106_abnormal_muscle_physiology1.38455630
58MP0004859_abnormal_synaptic_plasticity1.36972587
59MP0002139_abnormal_hepatobiliary_system1.36348175
60MP0008260_abnormal_autophagy1.35920990
61MP0003315_abnormal_perineum_morphology1.33623629
62MP0010630_abnormal_cardiac_muscle1.32567892
63MP0004885_abnormal_endolymph1.29104663
64MP0000759_abnormal_skeletal_muscle1.27568712
65MP0005385_cardiovascular_system_phenoty1.26095686
66MP0001544_abnormal_cardiovascular_syste1.26095686
67MP0004264_abnormal_extraembryonic_tissu1.25520252
68MP0001958_emphysema1.23698371
69MP0009672_abnormal_birth_weight1.23205595
70MP0003283_abnormal_digestive_organ1.22716058
71MP0005369_muscle_phenotype1.22445830
72MP0003329_amyloid_beta_deposits1.20474402
73MP0000762_abnormal_tongue_morphology1.16695874
74MP0005666_abnormal_adipose_tissue1.13978921
75MP0005501_abnormal_skin_physiology1.13531268
76MP0000383_abnormal_hair_follicle1.12403983
77MP0003385_abnormal_body_wall1.12336319
78MP0004130_abnormal_muscle_cell1.11957457
79MP0004957_abnormal_blastocyst_morpholog1.11344957
80MP0003942_abnormal_urinary_system1.10365917
81MP0003941_abnormal_skin_development1.10315848
82MP0003828_pulmonary_edema1.10091282
83MP0000920_abnormal_myelination1.09946165
84MP0002089_abnormal_postnatal_growth/wei1.08626389
85MP0001730_embryonic_growth_arrest1.07203210
86MP0010329_abnormal_lipoprotein_level1.05596661
87MP0005451_abnormal_body_composition1.04805464
88MP0003111_abnormal_nucleus_morphology1.04146377
89MP0001666_abnormal_nutrient_absorption1.04060647
90MP0005365_abnormal_bile_salt1.02315261
91MP0000516_abnormal_urinary_system1.02234898
92MP0005367_renal/urinary_system_phenotyp1.02234898
93MP0003221_abnormal_cardiomyocyte_apopto0.99276525
94MP0004272_abnormal_basement_membrane0.98708412
95MP0002234_abnormal_pharynx_morphology0.97436709
96MP0003938_abnormal_ear_development0.96662976
97MP0005375_adipose_tissue_phenotype0.95886965
98MP0000579_abnormal_nail_morphology0.95751483
99MP0003634_abnormal_glial_cell0.94717516
100MP0005360_urolithiasis0.94168708
101MP0001346_abnormal_lacrimal_gland0.93913526
102MP0005171_absent_coat_pigmentation0.93603714
103MP0000467_abnormal_esophagus_morphology0.92908368
104MP0002697_abnormal_eye_size0.92713475
105MP0009780_abnormal_chondrocyte_physiolo0.91516394
106MP0004085_abnormal_heartbeat0.90873276
107MP0003453_abnormal_keratinocyte_physiol0.90226221
108MP0000534_abnormal_ureter_morphology0.89445774
109MP0002108_abnormal_muscle_morphology0.88522820
110MP0003091_abnormal_cell_migration0.87581909
111MP0008569_lethality_at_weaning0.87273098
112MP0001502_abnormal_circadian_rhythm0.86273203
113MP0003861_abnormal_nervous_system0.85817570
114MP0005380_embryogenesis_phenotype0.84541412
115MP0001672_abnormal_embryogenesis/_devel0.84541412
116MP0008932_abnormal_embryonic_tissue0.82997741
117MP0003045_fibrosis0.82291713
118MP0003984_embryonic_growth_retardation0.81941379
119MP0004019_abnormal_vitamin_homeostasis0.79988128
120MP0000003_abnormal_adipose_tissue0.79246433
121MP0003119_abnormal_digestive_system0.78604677
122MP0002090_abnormal_vision0.77670822
123MP0001756_abnormal_urination0.77493381
124MP0002254_reproductive_system_inflammat0.76815556
125MP0001765_abnormal_ion_homeostasis0.75450345
126MP0005023_abnormal_wound_healing0.75349579
127MP0002088_abnormal_embryonic_growth/wei0.74740073
128MP0002085_abnormal_embryonic_tissue0.74613936
129MP0002971_abnormal_brown_adipose0.73484440
130MP0003690_abnormal_glial_cell0.73451597
131MP0001440_abnormal_grooming_behavior0.73427100
132MP0002092_abnormal_eye_morphology0.72579869
133MP0002896_abnormal_bone_mineralization0.71052550
134MP0003567_abnormal_fetal_cardiomyocyte0.70738455
135MP0005636_abnormal_mineral_homeostasis0.70686088
136MP0002086_abnormal_extraembryonic_tissu0.70478887
137MP0002332_abnormal_exercise_endurance0.70281362
138MP0003693_abnormal_embryo_hatching0.69970408
139MP0002080_prenatal_lethality0.69476339
140MP0002295_abnormal_pulmonary_circulatio0.69173406
141MP0010030_abnormal_orbit_morphology0.69169237
142MP0000538_abnormal_urinary_bladder0.68746619
143MP0000428_abnormal_craniofacial_morphol0.68738192
144MP0001697_abnormal_embryo_size0.68235664
145MP0003115_abnormal_respiratory_system0.68099458
146MP0001299_abnormal_eye_distance/0.67905055
147MP0002098_abnormal_vibrissa_morphology0.67517211
148MP0000377_abnormal_hair_follicle0.67187576
149MP0002111_abnormal_tail_morphology0.65536730

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.00016700
2Muscle fiber splitting (HP:0003555)4.89109716
3Cholecystitis (HP:0001082)4.08480363
4Abnormal gallbladder physiology (HP:0012438)4.08480363
5Hyporeflexia of lower limbs (HP:0002600)4.03552616
6Sudden death (HP:0001699)3.98051281
7Ventricular tachycardia (HP:0004756)3.82944288
8Bundle branch block (HP:0011710)3.59920452
9Difficulty running (HP:0009046)3.55458014
10Increased connective tissue (HP:0009025)3.54013694
11Difficulty climbing stairs (HP:0003551)3.48309737
12Exercise-induced muscle cramps (HP:0003710)3.32708622
13Truncus arteriosus (HP:0001660)3.32164388
14Exercise-induced myalgia (HP:0003738)3.30186534
15Reticulocytosis (HP:0001923)3.23825991
16Premature rupture of membranes (HP:0001788)3.20763464
17Ventricular fibrillation (HP:0001663)3.19023263
18Syncope (HP:0001279)3.03799173
19Deep venous thrombosis (HP:0002625)2.88533982
20Abnormality of reticulocytes (HP:0004312)2.79284182
21Ventricular arrhythmia (HP:0004308)2.78427265
22Abnormality of the calf musculature (HP:0001430)2.77087020
23Calf muscle hypertrophy (HP:0008981)2.66312910
24Partial duplication of thumb phalanx (HP:0009944)2.65502743
25Bowel incontinence (HP:0002607)2.64081610
26Muscle hypertrophy of the lower extremities (HP:0008968)2.63096296
27Insomnia (HP:0100785)2.61694092
28EMG: myopathic abnormalities (HP:0003458)2.61152372
29Ankyloglossia (HP:0010296)2.56878174
30Abnormal atrioventricular conduction (HP:0005150)2.56297369
31Mildly elevated creatine phosphokinase (HP:0008180)2.52960962
32Heart block (HP:0012722)2.51410788
33Abnormality of glycolysis (HP:0004366)2.46764671
34Type 1 muscle fiber predominance (HP:0003803)2.46511083
35Hemorrhage of the eye (HP:0011885)2.45601792
36Achilles tendon contracture (HP:0001771)2.44931466
37Upper limb amyotrophy (HP:0009129)2.44861227
38Distal upper limb amyotrophy (HP:0007149)2.44861227
39Atrioventricular block (HP:0001678)2.44432793
40Abnormal large intestine physiology (HP:0012700)2.43804101
41Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43651919
42Muscle fiber inclusion bodies (HP:0100299)2.40182732
43Acanthocytosis (HP:0001927)2.37946013
44Disproportionate tall stature (HP:0001519)2.37724725
45Atrophic scars (HP:0001075)2.34900946
46Abnormality of the aortic arch (HP:0012303)2.34163079
47Centrally nucleated skeletal muscle fibers (HP:0003687)2.33267624
48Cholelithiasis (HP:0001081)2.32061902
49Shallow orbits (HP:0000586)2.30897733
50Broad metatarsal (HP:0001783)2.28963440
51Scapular winging (HP:0003691)2.27941921
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.27924645
53Atrial fibrillation (HP:0005110)2.24804797
54Partial duplication of the phalanx of hand (HP:0009999)2.23921024
55Increased variability in muscle fiber diameter (HP:0003557)2.23421095
56Round ear (HP:0100830)2.21060675
57Prolonged QT interval (HP:0001657)2.20097176
58Neck muscle weakness (HP:0000467)2.19491797
59Hyperacusis (HP:0010780)2.18712263
60Primary atrial arrhythmia (HP:0001692)2.15638856
61Athetosis (HP:0002305)2.15497585
62Hyperthyroidism (HP:0000836)2.14632553
63Hypercholesterolemia (HP:0003124)2.12846840
64Xanthomatosis (HP:0000991)2.09815214
65Hip contracture (HP:0003273)2.09093623
66Distal lower limb muscle weakness (HP:0009053)2.07776877
67Segmental peripheral demyelination/remyelination (HP:0003481)2.07640632
68Abnormality of the Achilles tendon (HP:0005109)2.07487152
69Obstructive sleep apnea (HP:0002870)2.06250677
70Malnutrition (HP:0004395)2.05778045
71Abnormality of carpal bone ossification (HP:0006257)2.05423215
72Turricephaly (HP:0000262)2.05050302
73Lipoatrophy (HP:0100578)2.04556493
74Metabolic alkalosis (HP:0200114)2.03728540
75Nemaline bodies (HP:0003798)2.03576269
76Increased serum pyruvate (HP:0003542)2.03557869
77Alacrima (HP:0000522)2.03017588
78Polycythemia (HP:0001901)2.02743244
79Supraventricular arrhythmia (HP:0005115)2.02473820
80Hyperglycinuria (HP:0003108)2.02344909
81Renal duplication (HP:0000075)2.02033126
82Supraventricular tachycardia (HP:0004755)2.01411651
83Hypoplastic ischia (HP:0003175)2.00926494
84Broad palm (HP:0001169)2.00760448
85Increased circulating renin level (HP:0000848)1.99153382
86Ankle contracture (HP:0006466)1.98349562
87Vaginal fistula (HP:0004320)1.97840965
88Asymmetric septal hypertrophy (HP:0001670)1.95270711
89Distal lower limb amyotrophy (HP:0008944)1.94117779
90Myoglobinuria (HP:0002913)1.93651066
91Thin ribs (HP:0000883)1.93487705
92Poikilocytosis (HP:0004447)1.93347146
93Coronal craniosynostosis (HP:0004440)1.92493874
94Axonal loss (HP:0003447)1.91111546
95Peripheral hypomyelination (HP:0007182)1.90854148
96Hepatoblastoma (HP:0002884)1.90594987
97Abnormality of skeletal muscle fiber size (HP:0012084)1.90411036
98Ankle clonus (HP:0011448)1.90004187
99Palpitations (HP:0001962)1.89146000
100Pili torti (HP:0003777)1.88377646
101Abnormal gallbladder morphology (HP:0012437)1.88305556
102Aplasia involving bones of the extremities (HP:0009825)1.88287867
103Aplasia involving bones of the upper limbs (HP:0009823)1.88287867
104Aplasia of the phalanges of the hand (HP:0009802)1.88287867
105Abnormality of the tricuspid valve (HP:0001702)1.87790285
106Foot dorsiflexor weakness (HP:0009027)1.87584167
107Reticulocytopenia (HP:0001896)1.85251473
108Dilated cardiomyopathy (HP:0001644)1.85138415
109Abnormality of the shoulder girdle musculature (HP:0001435)1.84976029
110Increased cerebral lipofuscin (HP:0011813)1.84564343
111Fragile skin (HP:0001030)1.84352077
112Hand muscle atrophy (HP:0009130)1.82941513
113Abnormal ossification of hand bones (HP:0005921)1.82713184
114Abnormality of the umbilical cord (HP:0010881)1.82707411
115Milia (HP:0001056)1.82396839
116Dysmetric saccades (HP:0000641)1.82162973
117* Myopathic facies (HP:0002058)1.81502401
118Cerebral aneurysm (HP:0004944)1.80433988
119Protrusio acetabuli (HP:0003179)1.79271931
120Diaphragmatic weakness (HP:0009113)1.78811509
121Abnormality of the salivary glands (HP:0010286)1.78515411
122Abnormality of the foot musculature (HP:0001436)1.78358120
123Rapidly progressive (HP:0003678)1.78096190
124Choanal stenosis (HP:0000452)1.78062672
125Cerebral inclusion bodies (HP:0100314)1.77704017
126Gowers sign (HP:0003391)1.77217776
127Abnormal ventriculo-arterial connection (HP:0011563)1.76871633
128Transposition of the great arteries (HP:0001669)1.76871633
129Abnormal connection of the cardiac segments (HP:0011545)1.76871633
130Fragile nails (HP:0001808)1.76838016
131Hyperparathyroidism (HP:0000843)1.76533336
132Gout (HP:0001997)1.76464922
133Duplication of thumb phalanx (HP:0009942)1.75396021
134Neonatal death (HP:0003811)1.75304364
135Hyperactive renin-angiotensin system (HP:0000841)1.75278169
136Myotonia (HP:0002486)1.74712238
137Abnormal tarsal ossification (HP:0008369)1.74243064
138Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73020501
139Onion bulb formation (HP:0003383)1.72690723
140Abnormality of nail color (HP:0100643)1.72628784
141Cupped ribs (HP:0000887)1.70660856
142Flat acetabular roof (HP:0003180)1.70385193
143Abnormality of the gallbladder (HP:0005264)1.70144431
144Skin nodule (HP:0200036)1.69719900
145Ulnar bowing (HP:0003031)1.69341717
146Rhabdomyolysis (HP:0003201)1.68206407
147Neurofibrillary tangles (HP:0002185)1.66644309
148Abnormality of proline metabolism (HP:0010907)1.66405296
149Hydroxyprolinuria (HP:0003080)1.66405296
150Aplasia/Hypoplasia of the hallux (HP:0008362)1.65251710
151Confusion (HP:0001289)1.65249670
152Increased nuchal translucency (HP:0010880)1.65018300
153Short hallux (HP:0010109)1.64485429
154Abnormal EKG (HP:0003115)1.64342763
155Abnormality of glycolipid metabolism (HP:0010969)1.61854175
156Abnormality of liposaccharide metabolism (HP:0010968)1.61854175
157Abnormality of glycosphingolipid metabolism (HP:0004343)1.61854175
158Abnormality of oral frenula (HP:0000190)1.61763866
159Bronchomalacia (HP:0002780)1.61647146
160Shawl scrotum (HP:0000049)1.61495798
161Small epiphyses (HP:0010585)1.61154626
162Muscle stiffness (HP:0003552)1.60789507
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.60650969
164Absent epiphyses (HP:0010577)1.60650969
165Abnormality of serine family amino acid metabolism (HP:0010894)1.60169306
166Abnormality of glycine metabolism (HP:0010895)1.60169306
167Abnormality of the ischium (HP:0003174)1.59869384
168Lower limb amyotrophy (HP:0007210)1.59515258
169Seborrheic dermatitis (HP:0001051)1.59348049
170Hammertoe (HP:0001765)1.59302941
171Arnold-Chiari malformation (HP:0002308)1.58545152
172Supranuclear gaze palsy (HP:0000605)1.58181584
173Palmoplantar keratoderma (HP:0000982)1.57429479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.38291142
2TTN3.28094580
3EEF2K3.15605604
4AKT32.80881948
5FGFR42.69960825
6TRIB32.58250632
7SMG12.39215905
8DDR22.30421536
9LMTK22.22614860
10DMPK2.15672862
11MAP3K102.12067066
12STK392.09654803
13ICK2.04048779
14PDK22.02595584
15EPHB11.92375154
16PHKG21.89630647
17PHKG11.89630647
18RIPK11.88925129
19NEK11.88879022
20PRPF4B1.86608931
21SIK11.85180131
22MAP3K91.83281780
23PDK41.81341197
24PDK31.81341197
25MET1.72888279
26TYRO31.72442502
27NME11.69545291
28OXSR11.64036483
29WNK41.60742889
30NTRK31.50293221
31IRAK31.47023852
32MAP2K21.45059699
33MST1R1.45035595
34ERN11.44727033
35BMX1.44087278
36LATS21.42976926
37PAK31.40882669
38PAK61.40560149
39TAOK11.39798257
40MAP3K21.36401730
41KSR21.33845801
42FER1.25951017
43EIF2AK11.25119130
44LATS11.24929669
45PDGFRA1.24501954
46STK381.23833820
47PTK21.20173748
48FGFR31.19548340
49OBSCN1.15898186
50MAP3K31.14858537
51WNK11.14248588
52MYLK1.07117718
53CAMK2D1.04638149
54TAOK21.02521457
55PKN21.02336674
56PAK40.96800960
57KSR10.96719177
58EPHB20.96403166
59ROCK20.95355295
60PNCK0.94667420
61CAMK1D0.90866091
62ALK0.89930437
63PTK60.87313842
64NTRK10.87196378
65MAP3K10.86299913
66BRAF0.85961579
67MARK20.83343610
68PDPK10.82227838
69PRKD30.81849694
70DYRK1B0.79715400
71PRKD10.78565822
72FRK0.76119814
73RET0.75321624
74MST40.75214495
75PRKCI0.74529074
76ROCK10.74390263
77BRSK10.73890120
78CAMK2G0.71586498
79MAP2K10.71176129
80TTK0.70820216
81PIK3CA0.69819259
82SCYL20.69531714
83FGFR20.69165218
84UHMK10.69055985
85PRKG20.68516018
86MTOR0.66386212
87STK38L0.65898086
88STK110.64105585
89CDC42BPA0.63996816
90PINK10.63957826
91NEK20.63299165
92ERBB20.62686163
93PAK20.61024416
94PAK10.60950306
95NTRK20.60928975
96LIMK10.59875772
97CAMKK10.58532745
98DAPK30.57464119
99CDK180.56804412
100CAMK1G0.56376315
101EPHA40.56220700
102CDK70.55432562
103ILK0.54921661
104CAMK2B0.54885173
105MAP3K110.52291703
106PRKAA10.51027820
107ARAF0.49838833
108FGR0.49469598
109CDK120.47786715
110SIK20.46850688
111MAP3K60.46723202
112AKT20.46686625
113MAP2K30.46506265
114GSK3A0.46475652
115RPS6KA20.46372025
116MAP3K70.45479577
117SGK10.45381671
118MAPK100.44952575
119SGK30.44386864
120MAPK110.44247376
121PRKAA20.44244450
122RAF10.43629515
123PKN10.43268391
124MAP3K80.39973546
125SGK2230.39338061
126SGK4940.39338061
127NEK60.37433156
128CSNK1E0.37277361
129CDK20.37194161
130CDK140.36877007
131FGFR10.36672960
132CDK50.36397689
133CDK150.35585340
134MARK10.35339053
135PDK10.33346797
136CAMK2A0.32143898
137PRKCE0.30730444
138TESK20.30345727
139CDK11A0.29999167
140LRRK20.29514036

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049782.87165024
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.53498790
3Arginine biosynthesis_Homo sapiens_hsa002202.53023303
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.48048158
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11032065
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.08198355
7Tight junction_Homo sapiens_hsa045302.05231933
8Fat digestion and absorption_Homo sapiens_hsa049752.03807210
9Biosynthesis of amino acids_Homo sapiens_hsa012302.02625507
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.00749082
11Dilated cardiomyopathy_Homo sapiens_hsa054141.99940058
12Renin-angiotensin system_Homo sapiens_hsa046141.82953451
13Cardiac muscle contraction_Homo sapiens_hsa042601.79673668
14Fructose and mannose metabolism_Homo sapiens_hsa000511.72091383
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51192143
16Vitamin digestion and absorption_Homo sapiens_hsa049771.50918221
17Fatty acid biosynthesis_Homo sapiens_hsa000611.49320571
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.49255387
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48915098
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47689014
21Galactose metabolism_Homo sapiens_hsa000521.44775637
22Protein digestion and absorption_Homo sapiens_hsa049741.44638818
23Sphingolipid metabolism_Homo sapiens_hsa006001.37001481
24Pentose phosphate pathway_Homo sapiens_hsa000301.32822414
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32539297
26Prion diseases_Homo sapiens_hsa050201.31218689
27Lysosome_Homo sapiens_hsa041421.27788310
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26712745
29Hippo signaling pathway_Homo sapiens_hsa043901.25006045
30Collecting duct acid secretion_Homo sapiens_hsa049661.23981679
31Pyruvate metabolism_Homo sapiens_hsa006201.18182061
32Gastric acid secretion_Homo sapiens_hsa049711.17500887
33Renal cell carcinoma_Homo sapiens_hsa052111.15204399
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14781915
35Synaptic vesicle cycle_Homo sapiens_hsa047211.13089707
36Focal adhesion_Homo sapiens_hsa045101.10561341
37Sulfur relay system_Homo sapiens_hsa041221.08519641
38ECM-receptor interaction_Homo sapiens_hsa045121.06951022
39PPAR signaling pathway_Homo sapiens_hsa033201.06300449
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04746127
41Carbon metabolism_Homo sapiens_hsa012001.03844873
42Steroid biosynthesis_Homo sapiens_hsa001001.02611567
43Adherens junction_Homo sapiens_hsa045201.01402081
44Phenylalanine metabolism_Homo sapiens_hsa003601.01239128
45Vitamin B6 metabolism_Homo sapiens_hsa007501.00274679
46Proteoglycans in cancer_Homo sapiens_hsa052050.99894828
47Notch signaling pathway_Homo sapiens_hsa043300.99666763
48Arginine and proline metabolism_Homo sapiens_hsa003300.99543915
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99512244
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.98629616
51Bile secretion_Homo sapiens_hsa049760.98288381
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.96744615
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96656564
54Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96426530
55GnRH signaling pathway_Homo sapiens_hsa049120.96208209
56Gap junction_Homo sapiens_hsa045400.95487624
57Endocytosis_Homo sapiens_hsa041440.94110533
58mTOR signaling pathway_Homo sapiens_hsa041500.93996066
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93847715
60Histidine metabolism_Homo sapiens_hsa003400.91635637
61Hedgehog signaling pathway_Homo sapiens_hsa043400.91248053
62Axon guidance_Homo sapiens_hsa043600.89650129
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88441791
64Glucagon signaling pathway_Homo sapiens_hsa049220.85881094
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85223064
66Choline metabolism in cancer_Homo sapiens_hsa052310.84499029
67Salivary secretion_Homo sapiens_hsa049700.84088699
68Thyroid cancer_Homo sapiens_hsa052160.83807176
69Chronic myeloid leukemia_Homo sapiens_hsa052200.83640997
70Ribosome_Homo sapiens_hsa030100.82192815
71Oxytocin signaling pathway_Homo sapiens_hsa049210.82071135
72VEGF signaling pathway_Homo sapiens_hsa043700.80044177
73Other glycan degradation_Homo sapiens_hsa005110.78744389
74Vibrio cholerae infection_Homo sapiens_hsa051100.77839681
75Folate biosynthesis_Homo sapiens_hsa007900.77616679
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.75751465
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.74623275
78Bladder cancer_Homo sapiens_hsa052190.74479792
79Endometrial cancer_Homo sapiens_hsa052130.74300015
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.71916496
81Butanoate metabolism_Homo sapiens_hsa006500.70467403
82Long-term depression_Homo sapiens_hsa047300.70391893
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69587772
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69368503
85Inositol phosphate metabolism_Homo sapiens_hsa005620.67822822
86Glutathione metabolism_Homo sapiens_hsa004800.67787411
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66854121
88Amoebiasis_Homo sapiens_hsa051460.66037695
89Long-term potentiation_Homo sapiens_hsa047200.66017669
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65653506
91mRNA surveillance pathway_Homo sapiens_hsa030150.65501412
92AMPK signaling pathway_Homo sapiens_hsa041520.65149288
93Non-small cell lung cancer_Homo sapiens_hsa052230.64972560
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64822638
95Starch and sucrose metabolism_Homo sapiens_hsa005000.63208702
96ErbB signaling pathway_Homo sapiens_hsa040120.63123073
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60609296
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.59975243
99Type II diabetes mellitus_Homo sapiens_hsa049300.59952444
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59353805
101Lysine degradation_Homo sapiens_hsa003100.59156365
102Glioma_Homo sapiens_hsa052140.58666563
103Dorso-ventral axis formation_Homo sapiens_hsa043200.58247978
104Nitrogen metabolism_Homo sapiens_hsa009100.58117005
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58027009
106Pancreatic secretion_Homo sapiens_hsa049720.57734892
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.57694023
108Estrogen signaling pathway_Homo sapiens_hsa049150.56739414
109Melanogenesis_Homo sapiens_hsa049160.56525272
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.56415428
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55569308
112Insulin signaling pathway_Homo sapiens_hsa049100.55186888
113Regulation of autophagy_Homo sapiens_hsa041400.54144530
114Glycerolipid metabolism_Homo sapiens_hsa005610.54026148
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53365097
116HIF-1 signaling pathway_Homo sapiens_hsa040660.52819657
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51777680
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51573213
119Wnt signaling pathway_Homo sapiens_hsa043100.51182074
120MicroRNAs in cancer_Homo sapiens_hsa052060.50499071
121Renin secretion_Homo sapiens_hsa049240.50416282
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49741011
123Basal cell carcinoma_Homo sapiens_hsa052170.49692828
124Insulin resistance_Homo sapiens_hsa049310.49339078
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48627775
126Fatty acid metabolism_Homo sapiens_hsa012120.48250243
127Thyroid hormone synthesis_Homo sapiens_hsa049180.47839211
128Caffeine metabolism_Homo sapiens_hsa002320.46992055
129Glutamatergic synapse_Homo sapiens_hsa047240.46577277
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46552666
131Rap1 signaling pathway_Homo sapiens_hsa040150.46520958
132Ether lipid metabolism_Homo sapiens_hsa005650.46461843
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45330492
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44751869
135Insulin secretion_Homo sapiens_hsa049110.44157865
136Tyrosine metabolism_Homo sapiens_hsa003500.40581630
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.39487319
138Fatty acid degradation_Homo sapiens_hsa000710.37204506

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