SLC6A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indolalkylamine metabolic process (GO:0006586)8.62429907
2neuromuscular process controlling posture (GO:0050884)7.56527964
3amine biosynthetic process (GO:0009309)7.45174820
4cellular biogenic amine biosynthetic process (GO:0042401)7.45174820
5indole-containing compound metabolic process (GO:0042430)7.26614369
6dopamine biosynthetic process (GO:0042416)7.11200978
7toxin metabolic process (GO:0009404)6.80976082
8response to insecticide (GO:0017085)6.75713056
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.41534227
10proline transport (GO:0015824)6.38067033
11angiotensin maturation (GO:0002003)6.32510669
12oxygen transport (GO:0015671)5.64638982
13phenol-containing compound biosynthetic process (GO:0046189)5.52859227
14synaptic vesicle maturation (GO:0016188)5.24505741
15regulation of guanylate cyclase activity (GO:0031282)5.08799670
16regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.08463331
17regulation of short-term neuronal synaptic plasticity (GO:0048172)5.04520944
18regulation of respiratory gaseous exchange by neurological system process (GO:0002087)5.01028459
19dopamine transport (GO:0015872)4.98853483
20cellular response to lithium ion (GO:0071285)4.93687704
21synaptic vesicle exocytosis (GO:0016079)4.71927760
22neurotransmitter secretion (GO:0007269)4.62144854
23catecholamine biosynthetic process (GO:0042423)4.51234600
24catechol-containing compound biosynthetic process (GO:0009713)4.51234600
25positive regulation of guanylate cyclase activity (GO:0031284)4.42114342
26righting reflex (GO:0060013)4.41835583
27regulation of synapse structural plasticity (GO:0051823)4.38744060
28neurotransmitter catabolic process (GO:0042135)4.36819731
29catecholamine transport (GO:0051937)4.32613191
30regulation of bile acid biosynthetic process (GO:0070857)4.27588474
31regulation of dopamine metabolic process (GO:0042053)4.27411267
32regulation of catecholamine metabolic process (GO:0042069)4.27411267
33epoxygenase P450 pathway (GO:0019373)4.27241792
34exploration behavior (GO:0035640)4.21485801
35intestinal absorption (GO:0050892)4.20479098
36multicellular organismal aging (GO:0010259)4.19763219
37lipoprotein transport (GO:0042953)4.18017433
38startle response (GO:0001964)4.16342136
39dopamine metabolic process (GO:0042417)4.15018385
40regulation of synaptic vesicle exocytosis (GO:2000300)4.08357353
41* neurotransmitter transport (GO:0006836)4.05531086
42regulation of synaptic vesicle transport (GO:1902803)4.02991414
43peptide hormone processing (GO:0016486)3.98482059
44regulation of respiratory system process (GO:0044065)3.95238279
45negative regulation of glycogen metabolic process (GO:0070874)3.93259057
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.88959791
47vocalization behavior (GO:0071625)3.85169401
48negative regulation of neurotransmitter transport (GO:0051589)3.84565850
49* regulation of neurotransmitter levels (GO:0001505)3.83651118
50neuron maturation (GO:0042551)3.82852656
51digestion (GO:0007586)3.79683640
52L-fucose catabolic process (GO:0042355)3.79477246
53fucose catabolic process (GO:0019317)3.79477246
54L-fucose metabolic process (GO:0042354)3.79477246
55glutamate secretion (GO:0014047)3.76166938
56regulation of transmission of nerve impulse (GO:0051969)3.70574174
57phenol-containing compound catabolic process (GO:0019336)3.68754744
58endocrine process (GO:0050886)3.68241944
59regulation of systemic arterial blood pressure by hormone (GO:0001990)3.68241944
60regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.68241944
61auditory receptor cell differentiation (GO:0042491)3.67939738
62neurotransmitter metabolic process (GO:0042133)3.62710039
63behavioral response to cocaine (GO:0048148)3.59751949
64establishment of synaptic vesicle localization (GO:0097480)3.56397308
65synaptic vesicle transport (GO:0048489)3.56397308
66fat-soluble vitamin biosynthetic process (GO:0042362)3.56281842
67regulation of cGMP biosynthetic process (GO:0030826)3.55777720
68drug metabolic process (GO:0017144)3.52711700
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.48448655
70cerebellar Purkinje cell differentiation (GO:0021702)3.46967726
71negative regulation of synaptic transmission, GABAergic (GO:0032229)3.46342481
72high-density lipoprotein particle remodeling (GO:0034375)3.44660936
73layer formation in cerebral cortex (GO:0021819)3.38574530
74peptidyl-arginine omega-N-methylation (GO:0035247)3.37070557
75cellular response to ammonium ion (GO:0071242)3.36530573
76reverse cholesterol transport (GO:0043691)3.36137563
77activation of protein kinase A activity (GO:0034199)3.35389104
78cellular response to nitric oxide (GO:0071732)3.33205078
79neuron cell-cell adhesion (GO:0007158)3.30059635
80response to pheromone (GO:0019236)3.28710105
81regulation of systemic arterial blood pressure (GO:0003073)3.26875547
82relaxation of smooth muscle (GO:0044557)3.26839196
83peptide catabolic process (GO:0043171)3.25548660
84negative regulation of amino acid transport (GO:0051956)3.24911580
85drug catabolic process (GO:0042737)3.24508269
86locomotory exploration behavior (GO:0035641)3.22797360
87exogenous drug catabolic process (GO:0042738)3.18460326
88regulation of triglyceride catabolic process (GO:0010896)3.18125580
89bile acid and bile salt transport (GO:0015721)3.17668092
90gas transport (GO:0015669)3.16338214
91thrombin receptor signaling pathway (GO:0070493)3.16197072
92triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.13930402
93* monoamine transport (GO:0015844)3.13342597
94regulation of respiratory gaseous exchange (GO:0043576)3.11662225
95heme transport (GO:0015886)3.09506454
96positive regulation of cGMP biosynthetic process (GO:0030828)3.06524356
97aromatic amino acid family metabolic process (GO:0009072)3.06294000
98L-ascorbic acid metabolic process (GO:0019852)3.06190873
99response to histamine (GO:0034776)3.04588093
100regulation of glutamate receptor signaling pathway (GO:1900449)3.02938440
101response to lithium ion (GO:0010226)2.98655851
102transepithelial transport (GO:0070633)2.98300789
103phenol-containing compound metabolic process (GO:0018958)2.97311406
104catecholamine metabolic process (GO:0006584)2.94566297
105catechol-containing compound metabolic process (GO:0009712)2.94566297
106cerebellar Purkinje cell layer development (GO:0021680)2.93288618
107regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.91954438
108regulation of cGMP metabolic process (GO:0030823)2.91704293
109regulation of Rac protein signal transduction (GO:0035020)2.91131333
110regulation of lipoprotein metabolic process (GO:0050746)2.90462794
111peptidyl-arginine N-methylation (GO:0035246)2.89949644
112peptidyl-arginine methylation (GO:0018216)2.89949644
113inner ear receptor cell differentiation (GO:0060113)2.89940335
114vitamin biosynthetic process (GO:0009110)2.89251595
115cGMP biosynthetic process (GO:0006182)2.89133650
116phosphate ion homeostasis (GO:0055062)2.86969118
117trivalent inorganic anion homeostasis (GO:0072506)2.86969118
118cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86401937
119positive regulation of endothelial cell differentiation (GO:0045603)2.85076664
120regulation of vesicle fusion (GO:0031338)2.84674577
121cobalamin metabolic process (GO:0009235)2.83547619
122sulfate transmembrane transport (GO:1902358)2.82982947
123regulation of neuronal synaptic plasticity (GO:0048168)2.82177138
124protein localization to synapse (GO:0035418)2.80827037
125synaptic vesicle endocytosis (GO:0048488)2.79252441
126arginine metabolic process (GO:0006525)2.79221347
127adult walking behavior (GO:0007628)2.78743196
128hormone catabolic process (GO:0042447)2.78048528
129regulation of calcium ion-dependent exocytosis (GO:0017158)2.75726433
130response to cocaine (GO:0042220)2.75720187
131serotonin receptor signaling pathway (GO:0007210)2.75623164
132regulation of autophagic vacuole assembly (GO:2000785)2.75275925
133flavonoid metabolic process (GO:0009812)2.73974724
134cellular glucuronidation (GO:0052695)2.73602181
135neuron recognition (GO:0008038)2.72863473
136endocytic recycling (GO:0032456)2.72014517
137low-density lipoprotein particle remodeling (GO:0034374)2.71030270
138glucuronate metabolic process (GO:0019585)2.70331556
139uronic acid metabolic process (GO:0006063)2.70331556
140phosphatidylinositol acyl-chain remodeling (GO:0036149)2.70309109
141purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.69834499
1423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.69834499
143gamma-aminobutyric acid transport (GO:0015812)2.69526061
144regulation of cAMP-dependent protein kinase activity (GO:2000479)2.68994577
145glycerophospholipid catabolic process (GO:0046475)2.68515139
146sphingomyelin metabolic process (GO:0006684)2.68088164
147fat-soluble vitamin metabolic process (GO:0006775)2.66020038
148alanine transport (GO:0032328)2.65004035
149diacylglycerol metabolic process (GO:0046339)2.64960055
150cellular potassium ion homeostasis (GO:0030007)2.64578650
151phenylpropanoid metabolic process (GO:0009698)2.64324193
152phospholipid homeostasis (GO:0055091)2.64102285
153nitric oxide biosynthetic process (GO:0006809)2.63949332
154secondary metabolic process (GO:0019748)2.63259248
155establishment of vesicle localization (GO:0051650)2.62727022
156positive regulation of potassium ion transmembrane transport (GO:1901381)2.62345993
157regulation of glutamate secretion (GO:0014048)2.61859723
158regulation of protein glycosylation (GO:0060049)2.61720038
159vitamin D metabolic process (GO:0042359)2.61418284
160acrosome reaction (GO:0007340)2.61149879
161lipoprotein metabolic process (GO:0042157)2.60327238
162regulation of endothelial cell differentiation (GO:0045601)2.59901056
163phosphatidylserine acyl-chain remodeling (GO:0036150)2.59322749
164endocrine pancreas development (GO:0031018)2.57867806
165regulation of cholesterol esterification (GO:0010872)2.57475401
166cellular ketone body metabolic process (GO:0046950)2.56894850
167glycosylceramide metabolic process (GO:0006677)2.56664918
168plasma lipoprotein particle remodeling (GO:0034369)2.55358430
169protein-lipid complex remodeling (GO:0034368)2.55358430
170macromolecular complex remodeling (GO:0034367)2.55358430
171vitamin transport (GO:0051180)2.54505115
172xenobiotic catabolic process (GO:0042178)2.54048467
173surfactant homeostasis (GO:0043129)2.53271876
174virion attachment to host cell (GO:0019062)2.52953300
175adhesion of symbiont to host cell (GO:0044650)2.52953300
176very-low-density lipoprotein particle assembly (GO:0034379)2.51340179
177sulfation (GO:0051923)2.51066227
178iron coordination entity transport (GO:1901678)2.48998367
179renal system process involved in regulation of blood volume (GO:0001977)2.47979499
180mRNA modification (GO:0016556)2.47844827
181phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.47157271
182drug transmembrane transport (GO:0006855)2.46742591
183cytidine deamination (GO:0009972)2.45486301
184cytidine metabolic process (GO:0046087)2.45486301
185cytidine catabolic process (GO:0006216)2.45486301
186bile acid metabolic process (GO:0008206)2.44968551
187receptor guanylyl cyclase signaling pathway (GO:0007168)2.44448668
188serotonin metabolic process (GO:0042428)16.7283489
189primary amino compound metabolic process (GO:1901160)14.2262825
190alkaloid metabolic process (GO:0009820)11.6511223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.32800920
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.88486302
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.47573334
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.11148069
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03824232
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97456502
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91187554
8GBX2_23144817_ChIP-Seq_PC3_Human2.86870890
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70021886
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.64319903
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53502627
12ZNF274_21170338_ChIP-Seq_K562_Hela2.48276773
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.47723980
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44905894
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43646873
16REST_21632747_ChIP-Seq_MESCs_Mouse2.43267481
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.41440307
18* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40918783
19* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40918783
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38504258
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35652372
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32544152
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24188257
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23798728
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14829799
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.11297980
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.00184050
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97212041
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.94043369
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92187686
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.91329368
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.87839449
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.84540341
34VDR_22108803_ChIP-Seq_LS180_Human1.82737830
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.80653506
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79471411
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.78469311
38GATA1_22025678_ChIP-Seq_K562_Human1.78081683
39IGF1R_20145208_ChIP-Seq_DFB_Human1.71334333
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70565722
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.68024011
42DROSHA_22980978_ChIP-Seq_HELA_Human1.67242327
43SMAD4_21799915_ChIP-Seq_A2780_Human1.66543253
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66271215
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.65403191
46GATA4_25053715_ChIP-Seq_YYC3_Human1.65235138
47BCAT_22108803_ChIP-Seq_LS180_Human1.64298506
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62702468
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.61481862
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58070520
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55501423
52AR_21572438_ChIP-Seq_LNCaP_Human1.51059122
53* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50829997
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48394769
55* P300_19829295_ChIP-Seq_ESCs_Human1.48126787
56CDX2_22108803_ChIP-Seq_LS180_Human1.47497873
57RNF2_27304074_Chip-Seq_NSC_Mouse1.41808261
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36296855
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35778984
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.32969692
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.31869436
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31683515
63ER_23166858_ChIP-Seq_MCF-7_Human1.30890938
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30383872
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30113350
66* RING1B_27294783_Chip-Seq_ESCs_Mouse1.29937663
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.29856610
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26459388
69TAF15_26573619_Chip-Seq_HEK293_Human1.26275944
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25426262
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23544174
72TCF4_22108803_ChIP-Seq_LS180_Human1.23106222
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.22876567
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22272738
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.21482616
76NANOG_19829295_ChIP-Seq_ESCs_Human1.21183872
77SOX2_19829295_ChIP-Seq_ESCs_Human1.21183872
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21093772
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.21093772
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18652268
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18023201
82SOX2_20726797_ChIP-Seq_SW620_Human1.17938888
83RXR_22108803_ChIP-Seq_LS180_Human1.17932914
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17644455
85STAT3_23295773_ChIP-Seq_U87_Human1.17484346
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.17357975
87AR_25329375_ChIP-Seq_VCAP_Human1.17076498
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.16031534
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15814164
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15307230
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15191098
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.15002165
93P53_22387025_ChIP-Seq_ESCs_Mouse1.14710518
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.14706663
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14536546
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.14277438
97FUS_26573619_Chip-Seq_HEK293_Human1.13830651
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.11802846
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10050924
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09960874
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09834641
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.09547656
103* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09287665
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08355152
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08060535
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07886502
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07475787
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.07411689
109HTT_18923047_ChIP-ChIP_STHdh_Human1.06959721
110EWS_26573619_Chip-Seq_HEK293_Human1.06733263
111AR_20517297_ChIP-Seq_VCAP_Human1.06703785
112* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05797745
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05767818
114* TAL1_26923725_Chip-Seq_HPCs_Mouse1.05248978
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05218069
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05016246
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04321072
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04262172
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03374764
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02563340
121GATA3_21878914_ChIP-Seq_MCF-7_Human1.02250165
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02145024
123* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01489612
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01228893
125AR_19668381_ChIP-Seq_PC3_Human1.01089593
126CRX_20693478_ChIP-Seq_RETINA_Mouse0.99856742
127FOXA1_25552417_ChIP-Seq_VCAP_Human0.99762032
128GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99356398
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.99126788
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98772135
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98606593
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98423902
133STAT3_18555785_Chip-Seq_ESCs_Mouse0.98412674
134TP53_22573176_ChIP-Seq_HFKS_Human0.98410486
135IRF8_22096565_ChIP-ChIP_GC-B_Human0.98249828
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97304819
137RXR_22158963_ChIP-Seq_LIVER_Mouse0.97227589
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96589582
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.96504437
140SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95943907
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95501541
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95460898
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94534404
144JUN_21703547_ChIP-Seq_K562_Human0.94377152
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94003989
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.93788813
147TP53_18474530_ChIP-ChIP_U2OS_Human0.92618141
148* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91057594
149* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90389847
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89339478
151CBP_20019798_ChIP-Seq_JUKART_Human0.87111307
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87111307
153RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86656561
154TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86620946
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86377908
156CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86154610
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85229002
158* FLI1_21867929_ChIP-Seq_TH2_Mouse0.84803872
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.83819278
160SMAD_19615063_ChIP-ChIP_OVARY_Human0.83586174
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.83177953
162YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82679852
163AHR_22903824_ChIP-Seq_MCF-7_Human0.81860748
164TCF4_23295773_ChIP-Seq_U87_Human0.80642273

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006276_abnormal_autonomic_nervous7.20600010
2MP0003122_maternal_imprinting5.41958158
3* MP0001501_abnormal_sleep_pattern4.13483384
4MP0005085_abnormal_gallbladder_physiolo3.89632756
5MP0004147_increased_porphyrin_level3.80088930
6MP0003123_paternal_imprinting3.72029992
7MP0004859_abnormal_synaptic_plasticity3.71514023
8MP0004019_abnormal_vitamin_homeostasis3.64018601
9MP0009046_muscle_twitch3.48833477
10MP0005365_abnormal_bile_salt3.44733099
11MP0005645_abnormal_hypothalamus_physiol3.42500434
12MP0001666_abnormal_nutrient_absorption3.37699329
13MP0003635_abnormal_synaptic_transmissio2.98139315
14MP0010329_abnormal_lipoprotein_level2.95440456
15* MP0002572_abnormal_emotion/affect_behav2.72942295
16MP0003787_abnormal_imprinting2.45198560
17MP0004142_abnormal_muscle_tone2.43387685
18MP0002064_seizures2.43381288
19MP0009745_abnormal_behavioral_response2.41927889
20MP0005332_abnormal_amino_acid2.37576107
21MP0003329_amyloid_beta_deposits2.35741992
22MP0000569_abnormal_digit_pigmentation2.31842533
23MP0002909_abnormal_adrenal_gland2.28255259
24* MP0002272_abnormal_nervous_system2.26304090
25* MP0005535_abnormal_body_temperature2.18024203
26MP0002557_abnormal_social/conspecific_i2.13989927
27MP0001905_abnormal_dopamine_level2.13713823
28MP0003121_genomic_imprinting2.10779290
29MP0005386_behavior/neurological_phenoty2.09098535
30MP0004924_abnormal_behavior2.09098535
31MP0001486_abnormal_startle_reflex2.08027313
32MP0003183_abnormal_peptide_metabolism2.07975919
33* MP0002063_abnormal_learning/memory/cond2.07809554
34MP0003195_calcinosis2.07643629
35* MP0002733_abnormal_thermal_nociception2.00021811
36MP0004782_abnormal_surfactant_physiolog1.99076598
37MP0004270_analgesia1.96580167
38MP0009840_abnormal_foam_cell1.86831015
39MP0001440_abnormal_grooming_behavior1.85672679
40MP0005423_abnormal_somatic_nervous1.82112347
41MP0001765_abnormal_ion_homeostasis1.81037020
42MP0009643_abnormal_urine_homeostasis1.78587373
43MP0002184_abnormal_innervation1.76594091
44MP0001664_abnormal_digestion1.74658743
45MP0004264_abnormal_extraembryonic_tissu1.69916999
46MP0001756_abnormal_urination1.69445884
47MP0008877_abnormal_DNA_methylation1.68166405
48MP0005503_abnormal_tendon_morphology1.65727386
49MP0005646_abnormal_pituitary_gland1.65324231
50MP0005636_abnormal_mineral_homeostasis1.61923187
51MP0004145_abnormal_muscle_electrophysio1.61045646
52MP0008872_abnormal_physiological_respon1.56852694
53MP0001968_abnormal_touch/_nociception1.54735207
54MP0002118_abnormal_lipid_homeostasis1.53217138
55MP0001764_abnormal_homeostasis1.51010649
56MP0002067_abnormal_sensory_capabilities1.48679794
57MP0003880_abnormal_central_pattern1.45521148
58MP0000013_abnormal_adipose_tissue1.43468880
59MP0005448_abnormal_energy_balance1.41383445
60MP0004742_abnormal_vestibular_system1.38666783
61MP0005174_abnormal_tail_pigmentation1.38358207
62MP0002638_abnormal_pupillary_reflex1.37405793
63MP0002734_abnormal_mechanical_nocicepti1.36814694
64MP0001970_abnormal_pain_threshold1.36577167
65MP0000604_amyloidosis1.36155163
66MP0004043_abnormal_pH_regulation1.34738152
67MP0003724_increased_susceptibility_to1.33666298
68MP0005084_abnormal_gallbladder_morpholo1.31817898
69MP0005464_abnormal_platelet_physiology1.30127859
70MP0005551_abnormal_eye_electrophysiolog1.28880944
71MP0004085_abnormal_heartbeat1.25519161
72MP0002736_abnormal_nociception_after1.24542190
73MP0000230_abnormal_systemic_arterial1.21017147
74MP0000383_abnormal_hair_follicle1.20935384
75MP0003868_abnormal_feces_composition1.20650781
76MP0001502_abnormal_circadian_rhythm1.19586692
77* MP0002066_abnormal_motor_capabilities/c1.18843216
78MP0001485_abnormal_pinna_reflex1.17026752
79MP0003718_maternal_effect1.16413867
80MP0002136_abnormal_kidney_physiology1.15949445
81MP0000427_abnormal_hair_cycle1.15129040
82MP0010155_abnormal_intestine_physiology1.13853612
83MP0002693_abnormal_pancreas_physiology1.10339909
84MP0002078_abnormal_glucose_homeostasis1.10146557
85MP0010678_abnormal_skin_adnexa1.10001385
86* MP0002882_abnormal_neuron_morphology1.09722093
87* MP0008775_abnormal_heart_ventricle1.06317989
88MP0003632_abnormal_nervous_system1.05679857
89MP0003172_abnormal_lysosome_physiology1.05202543
90MP0005409_darkened_coat_color1.04577485
91MP0003879_abnormal_hair_cell1.04522392
92MP0005410_abnormal_fertilization1.03162186
93MP0005167_abnormal_blood-brain_barrier1.02095423
94MP0000015_abnormal_ear_pigmentation1.01577647
95MP0008874_decreased_physiological_sensi1.01391575
96MP0001348_abnormal_lacrimal_gland1.00911747
97MP0010234_abnormal_vibrissa_follicle1.00811785
98MP0004510_myositis1.00308819
99MP0001986_abnormal_taste_sensitivity0.99409039
100MP0002139_abnormal_hepatobiliary_system0.99289214
101MP0003638_abnormal_response/metabolism_0.97415713
102MP0004811_abnormal_neuron_physiology0.95892870
103MP0005379_endocrine/exocrine_gland_phen0.94992246
104MP0006054_spinal_hemorrhage0.93517954
105MP0000751_myopathy0.93156979
106MP0008875_abnormal_xenobiotic_pharmacok0.93071013
107MP0002138_abnormal_hepatobiliary_system0.92355295
108MP0009642_abnormal_blood_homeostasis0.91854684
109MP0004885_abnormal_endolymph0.89730598
110MP0002876_abnormal_thyroid_physiology0.88888046
111MP0000538_abnormal_urinary_bladder0.88639986
112MP0001944_abnormal_pancreas_morphology0.85616121
113MP0002102_abnormal_ear_morphology0.85463815
114MP0001299_abnormal_eye_distance/0.84678813
115MP0003866_abnormal_defecation0.84066276
116MP0002229_neurodegeneration0.83511927
117MP0008995_early_reproductive_senescence0.83462115
118MP0010386_abnormal_urinary_bladder0.83376305
119MP0000778_abnormal_nervous_system0.83220417
120MP0003075_altered_response_to0.81038753
121MP0002938_white_spotting0.78451404
122MP0008569_lethality_at_weaning0.77920858
123MP0003646_muscle_fatigue0.77436628
124* MP0003953_abnormal_hormone_level0.77023452
125MP0000372_irregular_coat_pigmentation0.76727558
126MP0000955_abnormal_spinal_cord0.76521794
127MP0004233_abnormal_muscle_weight0.75307840
128MP0009780_abnormal_chondrocyte_physiolo0.72402006
129MP0001958_emphysema0.72252342
130MP0003631_nervous_system_phenotype0.70080790
131MP0000249_abnormal_blood_vessel0.69798817
132MP0002254_reproductive_system_inflammat0.69665430
133MP0001943_abnormal_respiration0.69225275
134MP0002163_abnormal_gland_morphology0.68669441
135MP0005584_abnormal_enzyme/coenzyme_acti0.67209349
136MP0000747_muscle_weakness0.64913051
137MP0003252_abnormal_bile_duct0.64554289
138MP0003690_abnormal_glial_cell0.64531014
139MP0003283_abnormal_digestive_organ0.64334174
140MP0000579_abnormal_nail_morphology0.63873805
141MP0009697_abnormal_copulation0.62865536
142MP0008004_abnormal_stomach_pH0.60916838
143MP0001188_hyperpigmentation0.59859485
144MP0002108_abnormal_muscle_morphology0.59366417
145MP0003634_abnormal_glial_cell0.56303781
146MP0005360_urolithiasis0.53778189
147MP0002837_dystrophic_cardiac_calcinosis0.53343365
148MP0001963_abnormal_hearing_physiology0.53146005
149MP0001529_abnormal_vocalization0.52902207
150MP0003633_abnormal_nervous_system0.52335297
151MP0005058_abnormal_lysosome_morphology0.51260561
152MP0004883_abnormal_blood_vessel0.51059508
153MP0005595_abnormal_vascular_smooth0.48218467
154MP0004215_abnormal_myocardial_fiber0.47757974
155* MP0002152_abnormal_brain_morphology0.47601618
156MP0005076_abnormal_cell_differentiation0.46162536
157MP0004484_altered_response_of0.45832177
158MP0002069_abnormal_eating/drinking_beha0.45821304
159MP0002269_muscular_atrophy0.44708104
160* MP0010769_abnormal_survival0.44649309
161MP0000639_abnormal_adrenal_gland0.43688602
162MP0004858_abnormal_nervous_system0.43445358

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pupillary function (HP:0007686)9.75067587
2Limb dystonia (HP:0002451)9.44138651
3Limb hypertonia (HP:0002509)9.12987835
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.67869186
5Abnormality of vitamin B metabolism (HP:0004340)4.79670995
6Abnormality of proline metabolism (HP:0010907)4.46345055
7Hydroxyprolinuria (HP:0003080)4.46345055
8Abnormality of the vitamin B12 metabolism (HP:0004341)4.42759752
9Frequent falls (HP:0002359)4.28777905
10Focal seizures (HP:0007359)4.08361412
11Choreoathetosis (HP:0001266)4.06472373
12Myokymia (HP:0002411)4.04068123
13Hypokinesia (HP:0002375)4.03731110
14Agitation (HP:0000713)4.00550252
15Supranuclear gaze palsy (HP:0000605)3.79157368
16Potter facies (HP:0002009)3.78059073
17Facial shape deformation (HP:0011334)3.78059073
18Abnormality of vitamin metabolism (HP:0100508)3.69490850
19Poor suck (HP:0002033)3.67867514
20Acanthocytosis (HP:0001927)3.64202083
21Decreased circulating renin level (HP:0003351)3.63420106
22Hypobetalipoproteinemia (HP:0003563)3.63133913
23Glycosuria (HP:0003076)3.61411014
24Abnormality of urine glucose concentration (HP:0011016)3.61411014
25Visual hallucinations (HP:0002367)3.50217737
26Postural instability (HP:0002172)3.49644097
27Progressive cerebellar ataxia (HP:0002073)3.45270302
28Spontaneous abortion (HP:0005268)3.40585331
29Congenital sensorineural hearing impairment (HP:0008527)3.33277594
30Widely patent fontanelles and sutures (HP:0004492)3.25223215
31Action tremor (HP:0002345)3.24463049
32Malnutrition (HP:0004395)3.23239884
33Diminished movement (HP:0002374)3.18769158
34Chronic diarrhea (HP:0002028)3.09982769
35Spinal muscular atrophy (HP:0007269)3.08347295
36Absence seizures (HP:0002121)3.08142566
37Ankle clonus (HP:0011448)3.04590390
38Focal motor seizures (HP:0011153)3.01610947
39Pheochromocytoma (HP:0002666)3.00496348
40Xanthomatosis (HP:0000991)2.99759273
41Atonic seizures (HP:0010819)2.99101933
42Petechiae (HP:0000967)2.97341557
43Hyperglycinuria (HP:0003108)2.97175903
44Proximal tubulopathy (HP:0000114)2.96368327
45Hyperthyroidism (HP:0000836)2.93930536
46Generalized tonic-clonic seizures (HP:0002069)2.92032745
47Pigmentary retinal degeneration (HP:0001146)2.91608512
48Fat malabsorption (HP:0002630)2.84651591
49Confusion (HP:0001289)2.81182669
50Muscular hypotonia of the trunk (HP:0008936)2.81116805
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.79191248
52Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.79127173
53Failure to thrive in infancy (HP:0001531)2.79042114
54Anxiety (HP:0000739)2.77851294
55Hypotension (HP:0002615)2.76047936
56Papilledema (HP:0001085)2.72581829
57Enlarged epiphyses (HP:0010580)2.69778073
58Methylmalonic aciduria (HP:0012120)2.67215435
59Akinesia (HP:0002304)2.66427537
60Emotional lability (HP:0000712)2.65464973
61Abnormality of magnesium homeostasis (HP:0004921)2.64736420
62Vascular calcification (HP:0004934)2.63748466
63Large for gestational age (HP:0001520)2.62417607
64Hypercortisolism (HP:0001578)2.60910680
65Abnormality of renin-angiotensin system (HP:0000847)2.59916955
66Hypomagnesemia (HP:0002917)2.59621757
67Hyperventilation (HP:0002883)2.57205406
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.56985073
69Abnormality of serine family amino acid metabolism (HP:0010894)2.54520687
70Abnormality of glycine metabolism (HP:0010895)2.54520687
71Neuroendocrine neoplasm (HP:0100634)2.53166674
72Megaloblastic anemia (HP:0001889)2.52665413
73Prolonged bleeding time (HP:0003010)2.52005982
74Metabolic alkalosis (HP:0200114)2.51847922
75Myoclonus (HP:0001336)2.51843877
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.51703538
77Menorrhagia (HP:0000132)2.51002110
78Methylmalonic acidemia (HP:0002912)2.45844490
79Ketoacidosis (HP:0001993)2.45061917
80Hyperlipoproteinemia (HP:0010980)2.41938415
81Abnormal albumin level (HP:0012116)2.41728725
82Hypoalbuminemia (HP:0003073)2.41728725
83Hyperactive renin-angiotensin system (HP:0000841)2.40816011
84Generalized hypotonia (HP:0001290)2.37794336
85Torticollis (HP:0000473)2.37515349
86Attenuation of retinal blood vessels (HP:0007843)2.36520531
87Abnormality of the renal cortex (HP:0011035)2.36270799
88Dialeptic seizures (HP:0011146)2.35639460
89Ketosis (HP:0001946)2.33296933
90Nausea (HP:0002018)2.33164591
91Tachypnea (HP:0002789)2.26920517
92Alkalosis (HP:0001948)2.26330434
93Psychosis (HP:0000709)2.26101936
94Hypoglycemic coma (HP:0001325)2.25453906
95Postural tremor (HP:0002174)2.24323497
96Cerebral palsy (HP:0100021)2.24058076
97Neurofibrillary tangles (HP:0002185)2.22830964
98Polyphagia (HP:0002591)2.22625569
99Renal cortical cysts (HP:0000803)2.21640024
100Ileus (HP:0002595)2.20798240
101Cardiovascular calcification (HP:0011915)2.19843771
102Mutism (HP:0002300)2.16546189
103Hypophosphatemic rickets (HP:0004912)2.16505953
104Abnormality of renal excretion (HP:0011036)2.15922292
105Gastroesophageal reflux (HP:0002020)2.14156178
106Poikilocytosis (HP:0004447)2.13754748
107Generalized aminoaciduria (HP:0002909)2.13037929
108Irritability (HP:0000737)2.11802838
109Interstitial pulmonary disease (HP:0006530)2.11689431
110Genetic anticipation (HP:0003743)2.11205845
111Anosmia (HP:0000458)2.10791039
112Menstrual irregularities (HP:0000858)2.10456815
113Steatorrhea (HP:0002570)2.10428133
114Febrile seizures (HP:0002373)2.07577069
115Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.07318735
116Truncal ataxia (HP:0002078)2.06371358
117Cerebral inclusion bodies (HP:0100314)2.05921445
118Abnormal glucose tolerance (HP:0001952)2.05265685
119Abnormal urine output (HP:0012590)2.03255869
120Stomatitis (HP:0010280)2.01827251
121Urinary bladder sphincter dysfunction (HP:0002839)2.01752118
122Epileptic encephalopathy (HP:0200134)2.01108294
123Epidermoid cyst (HP:0200040)2.00954356
124Hypothermia (HP:0002045)12.3370466
125Sleep apnea (HP:0010535)1.99044394
126Congenital stationary night blindness (HP:0007642)1.96934684
127Depression (HP:0000716)1.94948181
128Abnormality of the pupil (HP:0000615)1.94411011
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93710320
130Dicarboxylic aciduria (HP:0003215)1.93710320
131Alveolar cell carcinoma (HP:0006519)1.93176770
132Late onset (HP:0003584)1.92983849
133Restlessness (HP:0000711)1.92264390
134Abnormal biliary tract morphology (HP:0012440)1.91960568
135Hypolipoproteinemia (HP:0010981)1.90157506
136Abnormality of calcium-phosphate metabolism (HP:0100530)1.88896113
137Craniofacial dystonia (HP:0012179)1.88733236
138Abnormal eating behavior (HP:0100738)1.88261903
139Hyperphosphaturia (HP:0003109)1.88145333
140Status epilepticus (HP:0002133)1.87460159
141Glomerulonephritis (HP:0000099)1.86172283
142Fetal akinesia sequence (HP:0001989)1.86146949
143Abolished electroretinogram (ERG) (HP:0000550)1.85441618
144Abnormality of pain sensation (HP:0010832)1.84646691
145Impaired pain sensation (HP:0007328)1.84646691
146Joint swelling (HP:0001386)1.84573489
147Abnormality of sulfur amino acid metabolism (HP:0004339)1.84054374
148Purpura (HP:0000979)1.83737558
149Abnormal urine phosphate concentration (HP:0012599)1.82708812
150Nephrolithiasis (HP:0000787)1.82239084
151Lethargy (HP:0001254)1.81669139
152Oligomenorrhea (HP:0000876)1.81041643
153Increased mean platelet volume (HP:0011877)1.80884723
154Increased circulating renin level (HP:0000848)1.80810755
155Mitral stenosis (HP:0001718)1.79921440
156Focal dystonia (HP:0004373)1.79151642
157Hyperinsulinemic hypoglycemia (HP:0000825)1.78891007
158Urinary urgency (HP:0000012)1.77549483
159Metabolic acidosis (HP:0001942)1.77455890
160Neoplasm of the tracheobronchial system (HP:0100552)1.76900389
161Hematochezia (HP:0002573)1.76898885
162Bony spicule pigmentary retinopathy (HP:0007737)1.75644193
163Congenital, generalized hypertrichosis (HP:0004540)1.75036777
164Abnormality of the corticospinal tract (HP:0002492)1.74442820
165Broad-based gait (HP:0002136)1.74159043
166Bradykinesia (HP:0002067)1.73522462
167Polydipsia (HP:0001959)1.73442683
168Abnormal drinking behavior (HP:0030082)1.73442683
169Cubitus valgus (HP:0002967)1.72889417
170Generalized myoclonic seizures (HP:0002123)1.70972897
171Drooling (HP:0002307)1.70362305
172Excessive salivation (HP:0003781)1.70362305
173Cerebral hemorrhage (HP:0001342)1.69684177
174Progressive inability to walk (HP:0002505)1.69240677
175Hypoventilation (HP:0002791)1.67497140
176Enlarged penis (HP:0000040)1.67104974
177Esotropia (HP:0000565)1.66706689
178Rigidity (HP:0002063)1.66458937
179Neonatal onset (HP:0003623)1.65889456
180Palpitations (HP:0001962)1.65872077
181Concave nail (HP:0001598)1.65092972
182Lower limb muscle weakness (HP:0007340)1.63184985
183Amblyopia (HP:0000646)1.63109247
184Obstructive sleep apnea (HP:0002870)1.62755382
185Aplasia of the musculature (HP:0100854)1.62736213
186Striae distensae (HP:0001065)1.61907350
187EMG: neuropathic changes (HP:0003445)1.61577686
188Lower limb amyotrophy (HP:0007210)1.61064576
189Slow saccadic eye movements (HP:0000514)1.60184161
190Blue irides (HP:0000635)1.59286055
191Neoplasm of the peripheral nervous system (HP:0100007)1.59157265
192Dysmetria (HP:0001310)1.59114654
193Spastic gait (HP:0002064)1.59052804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK36.40382000
2ACVR1B5.92069302
3FRK5.48334071
4PNCK4.20673246
5MST43.70109996
6MAP3K43.43366224
7MAP3K93.43350233
8MINK13.14995169
9ADRBK22.69514039
10CDK192.47705240
11CSNK1G32.46461770
12MAP4K22.44648022
13UHMK12.37585173
14GRK12.37553875
15CSNK1G22.32780746
16PAK62.31037511
17WNK32.30012379
18BMPR1B2.26050749
19PAK32.14387250
20MAP2K42.06547810
21TAOK12.05290767
22MAP3K121.93938926
23AKT31.87638809
24MARK11.79702154
25MAP2K71.74327247
26CSNK1G11.68142163
27* CAMK2A1.68046663
28NTRK11.66642713
29LATS21.65067734
30TAOK31.64070480
31ALK1.61465692
32NTRK21.56790802
33INSRR1.47413304
34GRK51.47097987
35PTK2B1.47017944
36TIE11.43348236
37TNIK1.40212439
38CAMK1G1.37545112
39STK241.36040899
40MYLK1.30581929
41FGFR21.29679171
42EPHA31.29190009
43PRKG21.28076315
44TEC1.25836012
45STK38L1.25015679
46PRKCG1.18737081
47MAP2K61.17004030
48MAPK131.16756421
49DAPK21.14482216
50FER1.10079292
51CDK51.08384696
52TLK11.07074625
53PRKCE1.03936821
54STK111.03044519
55OXSR11.01364526
56SIK20.99685677
57LIMK10.99251819
58STK30.96248025
59FGFR30.94077189
60NUAK10.91303826
61BMX0.91273562
62SCYL20.90496395
63CSF1R0.86612312
64NLK0.86510586
65PHKG20.85134541
66PHKG10.85134541
67LMTK20.84817060
68RIPK10.83488783
69PIK3CG0.82116309
70PRKCZ0.80987641
71TRPM70.80198972
72MET0.79482697
73CAMK2G0.79320694
74STK390.78130346
75MAPKAPK50.78079712
76MAP3K130.77643375
77CAMK10.75241677
78CDK140.74958177
79PRKCH0.72785811
80GRK70.72617872
81IRAK10.72372015
82ITK0.72332157
83KSR20.71531240
84CASK0.69853615
85SYK0.69751358
86PRKAA20.67835629
87TXK0.66854667
88CAMKK10.66212684
89SIK10.64776226
90FES0.64561344
91ADRBK10.63008873
92PLK20.61472893
93WNK40.60810453
94NEK10.60741071
95BCR0.60258668
96MKNK20.59424575
97RIPK40.58186669
98JAK20.56526791
99PIK3CA0.56456675
100WNK10.55779830
101PINK10.55482651
102MOS0.55390013
103FGR0.54438241
104PDK10.54231322
105PRKACA0.53511445
106IKBKB0.52511697
107CSNK1A10.52430766
108RPS6KA30.52087110
109PKN10.51918414
110SGK10.51222707
111CDK150.50466230
112ERBB30.49269417
113MAPK150.47743439
114CDK180.47678832
115TRIM280.47645527
116STK380.47415116
117JAK10.47381533
118CAMKK20.47184670
119ERBB20.47005284
120CAMK40.46283905
121FGFR40.45771486
122CDC42BPA0.45400604
123ZAK0.44877168
124RPS6KA20.44766742
125RET0.44090475
126ARAF0.43856983
127* PRKCA0.42883605
128CDK11A0.42775855
129SGK20.42615635
130FYN0.41869025
131PRKAA10.40881124
132MST1R0.40650210
133FGFR10.40575518
134BTK0.39683327
135PDPK10.39574720
136MAP2K10.39501065
137MAPK120.39089389
138EGFR0.38703588
139MAP3K20.37474169
140PRKACG0.37260900
141IGF1R0.36814656
142MATK0.36614638
143CSNK1E0.36365827
144PRKCQ0.35704833
145MAPK40.35639147
146PDK20.35304357
147TRIB30.35112205
148MAPKAPK30.34733564
149DAPK10.34053600
150PRKACB0.34010349
151MELK0.33695441
152PRKCB0.33511660
153* PRKG10.33028099
154YES10.32746807
155MAPK80.32322320
156MAPK110.31393968
157LYN0.31309039
158TYRO30.30376908
159DAPK30.29691282
160MAPK100.29536791
161CAMK2D0.28180984

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003605.07643465
2Tryptophan metabolism_Homo sapiens_hsa003804.04818795
3Histidine metabolism_Homo sapiens_hsa003403.84762867
4Vitamin digestion and absorption_Homo sapiens_hsa049773.65449504
5Cocaine addiction_Homo sapiens_hsa050303.59914529
6* Serotonergic synapse_Homo sapiens_hsa047263.47018764
7Synaptic vesicle cycle_Homo sapiens_hsa047213.35689168
8Fat digestion and absorption_Homo sapiens_hsa049753.32770788
9Maturity onset diabetes of the young_Homo sapiens_hsa049503.31093703
10Renin-angiotensin system_Homo sapiens_hsa046143.04541274
11Tyrosine metabolism_Homo sapiens_hsa003502.86273814
12Amphetamine addiction_Homo sapiens_hsa050312.85462252
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76398264
14Linoleic acid metabolism_Homo sapiens_hsa005912.65455331
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.64835641
16Mineral absorption_Homo sapiens_hsa049782.55961990
17Dopaminergic synapse_Homo sapiens_hsa047282.33134405
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26776874
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.22089705
20GABAergic synapse_Homo sapiens_hsa047272.21608609
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15122087
22Nicotine addiction_Homo sapiens_hsa050332.08304234
23Sulfur relay system_Homo sapiens_hsa041222.07966996
24Starch and sucrose metabolism_Homo sapiens_hsa005001.92411308
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90160872
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86937059
27Chemical carcinogenesis_Homo sapiens_hsa052041.85668140
28Ether lipid metabolism_Homo sapiens_hsa005651.82068795
29Caffeine metabolism_Homo sapiens_hsa002321.81330168
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78190279
31Sulfur metabolism_Homo sapiens_hsa009201.75446123
32Retinol metabolism_Homo sapiens_hsa008301.71625927
33Protein digestion and absorption_Homo sapiens_hsa049741.71010032
34Arachidonic acid metabolism_Homo sapiens_hsa005901.62650289
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61254175
36Salivary secretion_Homo sapiens_hsa049701.61190571
37Morphine addiction_Homo sapiens_hsa050321.56544284
38Collecting duct acid secretion_Homo sapiens_hsa049661.56046818
39Insulin secretion_Homo sapiens_hsa049111.54569386
40Taste transduction_Homo sapiens_hsa047421.54082870
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52790390
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48068880
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41832649
44Olfactory transduction_Homo sapiens_hsa047401.40946550
45PPAR signaling pathway_Homo sapiens_hsa033201.40430570
46Circadian entrainment_Homo sapiens_hsa047131.34602655
47ABC transporters_Homo sapiens_hsa020101.32659983
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31955328
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23843109
50Glutamatergic synapse_Homo sapiens_hsa047241.20234716
51Vibrio cholerae infection_Homo sapiens_hsa051101.20155363
52Sphingolipid metabolism_Homo sapiens_hsa006001.17663715
53Renin secretion_Homo sapiens_hsa049241.17512049
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11945433
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11241481
56Fatty acid degradation_Homo sapiens_hsa000711.10394871
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10124960
58Butanoate metabolism_Homo sapiens_hsa006501.01849391
59Gap junction_Homo sapiens_hsa045401.01563511
60Cholinergic synapse_Homo sapiens_hsa047251.00040497
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.99838280
62Peroxisome_Homo sapiens_hsa041460.98732469
63Selenocompound metabolism_Homo sapiens_hsa004500.97673622
64Long-term depression_Homo sapiens_hsa047300.93637876
65Phototransduction_Homo sapiens_hsa047440.91832464
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91489929
67Gastric acid secretion_Homo sapiens_hsa049710.91039072
68Cardiac muscle contraction_Homo sapiens_hsa042600.90950130
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90173719
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89440950
71Galactose metabolism_Homo sapiens_hsa000520.89341572
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87789441
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87490220
74Long-term potentiation_Homo sapiens_hsa047200.84805501
75Dorso-ventral axis formation_Homo sapiens_hsa043200.84126661
76Arginine and proline metabolism_Homo sapiens_hsa003300.83196734
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82365782
78Oxytocin signaling pathway_Homo sapiens_hsa049210.81328357
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.79542381
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79252461
81Type II diabetes mellitus_Homo sapiens_hsa049300.79064231
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79037693
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.75165379
84GnRH signaling pathway_Homo sapiens_hsa049120.75109815
85Bile secretion_Homo sapiens_hsa049760.73338971
86Steroid biosynthesis_Homo sapiens_hsa001000.70824440
87Alcoholism_Homo sapiens_hsa050340.66295957
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65817814
89Fatty acid biosynthesis_Homo sapiens_hsa000610.65470332
90Propanoate metabolism_Homo sapiens_hsa006400.62615899
91Thyroid hormone synthesis_Homo sapiens_hsa049180.62085683
92Glutathione metabolism_Homo sapiens_hsa004800.59979929
93Estrogen signaling pathway_Homo sapiens_hsa049150.59825310
94Nitrogen metabolism_Homo sapiens_hsa009100.59050067
95Dilated cardiomyopathy_Homo sapiens_hsa054140.58884763
96Asthma_Homo sapiens_hsa053100.58460014
97Type I diabetes mellitus_Homo sapiens_hsa049400.56144199
98Fructose and mannose metabolism_Homo sapiens_hsa000510.56058692
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55557716
100cAMP signaling pathway_Homo sapiens_hsa040240.53778363
101Fatty acid elongation_Homo sapiens_hsa000620.53714337
102Fatty acid metabolism_Homo sapiens_hsa012120.53580548
103beta-Alanine metabolism_Homo sapiens_hsa004100.52872042
104Phagosome_Homo sapiens_hsa041450.51270227
105Choline metabolism in cancer_Homo sapiens_hsa052310.49061421
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48361315
107Platelet activation_Homo sapiens_hsa046110.47440555
108MAPK signaling pathway_Homo sapiens_hsa040100.47167700
109Calcium signaling pathway_Homo sapiens_hsa040200.47162915
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46929144
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46626982
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43151788
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.42179901
114Complement and coagulation cascades_Homo sapiens_hsa046100.41991263
115Prion diseases_Homo sapiens_hsa050200.41737678
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40191239
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39945057
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.38147305
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.37774418
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37338788
121Metabolic pathways_Homo sapiens_hsa011000.36580210
122Circadian rhythm_Homo sapiens_hsa047100.35870907
123Ovarian steroidogenesis_Homo sapiens_hsa049130.35314282
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34754831
125Protein export_Homo sapiens_hsa030600.34714091
126Axon guidance_Homo sapiens_hsa043600.34257292
127Rheumatoid arthritis_Homo sapiens_hsa053230.34075455
128ErbB signaling pathway_Homo sapiens_hsa040120.33986546
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33530735
130Arginine biosynthesis_Homo sapiens_hsa002200.33459003
131Ras signaling pathway_Homo sapiens_hsa040140.31816956
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29521094
133Insulin resistance_Homo sapiens_hsa049310.29403418
134Melanogenesis_Homo sapiens_hsa049160.28789115
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28389571
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28310228
137Folate biosynthesis_Homo sapiens_hsa007900.27718016
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27710201
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27580585
140Parkinsons disease_Homo sapiens_hsa050120.27097685
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.26243190
142Oxidative phosphorylation_Homo sapiens_hsa001900.24263017
143Pancreatic secretion_Homo sapiens_hsa049720.23586859
144Allograft rejection_Homo sapiens_hsa053300.23235845
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.22599541
146Glycerolipid metabolism_Homo sapiens_hsa005610.21632184
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.20185859
148Salmonella infection_Homo sapiens_hsa051320.20077891
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.19102981
150Pentose phosphate pathway_Homo sapiens_hsa000300.18627108
151Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18283789
152Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17429299
153Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16947411
154Glucagon signaling pathway_Homo sapiens_hsa049220.16853908

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