SLC6A15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.78787410
2synaptic vesicle exocytosis (GO:0016079)5.38885731
3vocalization behavior (GO:0071625)5.30703945
4neuron cell-cell adhesion (GO:0007158)5.17453528
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.11581693
6protein localization to synapse (GO:0035418)5.11042024
7synaptic vesicle maturation (GO:0016188)5.09212771
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08564784
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.95068992
10glutamate secretion (GO:0014047)4.88870271
11locomotory exploration behavior (GO:0035641)4.85980759
12regulation of glutamate receptor signaling pathway (GO:1900449)4.72257364
13regulation of synaptic vesicle exocytosis (GO:2000300)4.72205140
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.49515981
15exploration behavior (GO:0035640)4.48678384
16layer formation in cerebral cortex (GO:0021819)4.40367894
17neuronal action potential propagation (GO:0019227)4.33808732
18neurotransmitter secretion (GO:0007269)4.32887633
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.30771947
20regulation of synaptic vesicle transport (GO:1902803)4.17984832
21glutamate receptor signaling pathway (GO:0007215)4.17582695
22neurotransmitter-gated ion channel clustering (GO:0072578)4.16014426
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.15555922
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01871823
25neuron recognition (GO:0008038)4.01428972
26pyrimidine nucleobase catabolic process (GO:0006208)4.00244801
27synaptic transmission, glutamatergic (GO:0035249)3.99639307
28neuron-neuron synaptic transmission (GO:0007270)3.95651961
29regulation of neuronal synaptic plasticity (GO:0048168)3.92328445
30regulation of synapse structural plasticity (GO:0051823)3.90941961
31positive regulation of synapse maturation (GO:0090129)3.88675241
32positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.81812145
33negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.78642612
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.70320592
35cell migration in hindbrain (GO:0021535)3.68256946
36gamma-aminobutyric acid transport (GO:0015812)3.67036449
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.63518188
38* neurotransmitter transport (GO:0006836)3.63413322
39axonal fasciculation (GO:0007413)3.56147656
40DNA double-strand break processing (GO:0000729)3.55016452
41dendritic spine morphogenesis (GO:0060997)3.53678599
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53377124
43cellular potassium ion homeostasis (GO:0030007)3.52748602
44postsynaptic membrane organization (GO:0001941)3.52471836
45regulation of synaptic transmission, glutamatergic (GO:0051966)3.52225181
46melanin biosynthetic process (GO:0042438)3.49410255
47long-term memory (GO:0007616)3.48753890
48regulation of postsynaptic membrane potential (GO:0060078)3.48655318
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40458800
50behavioral fear response (GO:0001662)3.40031788
51behavioral defense response (GO:0002209)3.40031788
52transmission of nerve impulse (GO:0019226)3.40014624
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39928739
54* proline transport (GO:0015824)3.37427017
55synaptic vesicle endocytosis (GO:0048488)3.36145294
56innervation (GO:0060384)3.36038384
57regulation of neurotransmitter levels (GO:0001505)3.34639730
58positive regulation of membrane potential (GO:0045838)3.34407271
59negative regulation of microtubule polymerization (GO:0031115)3.31513477
60regulation of neurotransmitter secretion (GO:0046928)3.30480822
61response to histamine (GO:0034776)3.29555071
62presynaptic membrane assembly (GO:0097105)3.28991350
63long-term synaptic potentiation (GO:0060291)3.28864540
64regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.28352420
65sodium ion export (GO:0071436)3.27777328
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26427689
67regulation of synaptic plasticity (GO:0048167)3.25237185
68hemidesmosome assembly (GO:0031581)3.23705124
69regulation of dendritic spine morphogenesis (GO:0061001)3.23701259
70fear response (GO:0042596)3.22315181
71synapse assembly (GO:0007416)3.22130582
72cerebellar Purkinje cell differentiation (GO:0021702)3.21498811
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21029544
74membrane depolarization during action potential (GO:0086010)3.19330090
75regulation of vesicle fusion (GO:0031338)3.19247984
76neuromuscular process controlling posture (GO:0050884)3.12821715
77membrane depolarization (GO:0051899)3.12772391
78positive regulation of dendritic spine morphogenesis (GO:0061003)3.12570934
79activation of protein kinase A activity (GO:0034199)3.12436482
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11710717
81organelle transport along microtubule (GO:0072384)3.11663752
82nucleobase catabolic process (GO:0046113)3.11303892
83secondary metabolite biosynthetic process (GO:0044550)3.10941104
84dendrite morphogenesis (GO:0048813)3.09206197
85regulation of neurotransmitter transport (GO:0051588)3.07377318
86mating behavior (GO:0007617)3.06275937
87presynaptic membrane organization (GO:0097090)3.06264886
88vesicle transport along microtubule (GO:0047496)3.05764842
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05607490
90sympathetic nervous system development (GO:0048485)3.05467900
91negative regulation of dendrite development (GO:2000171)3.04727412
92synaptic transmission (GO:0007268)3.02866630
93regulation of synapse maturation (GO:0090128)3.01481707
94positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00226764
95cullin deneddylation (GO:0010388)2.99736144
96cell communication by electrical coupling (GO:0010644)2.99515704
97positive regulation of neurotransmitter secretion (GO:0001956)2.98966829
98learning (GO:0007612)2.98580216
99auditory behavior (GO:0031223)2.97559078
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97481334
101regulation of mitotic spindle checkpoint (GO:1903504)2.97481334
102neuromuscular process controlling balance (GO:0050885)2.97295136
103melanin metabolic process (GO:0006582)2.96522786
104social behavior (GO:0035176)2.96125801
105intraspecies interaction between organisms (GO:0051703)2.96125801
106negative regulation of dendrite morphogenesis (GO:0050774)2.94922363
107membrane hyperpolarization (GO:0060081)2.94807867
108G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.94148171
109positive regulation of neurotransmitter transport (GO:0051590)2.93453408
110response to pheromone (GO:0019236)2.93254278
111prepulse inhibition (GO:0060134)2.92897174
112DNA damage response, detection of DNA damage (GO:0042769)2.92696335
113positive regulation of dendritic spine development (GO:0060999)2.92584754
114regulation of synaptic transmission (GO:0050804)2.91475887
115ganglion development (GO:0061548)2.90448261
116negative regulation of DNA recombination (GO:0045910)2.90324571
117chromatin remodeling at centromere (GO:0031055)2.79429031
118nuclear pore complex assembly (GO:0051292)2.77630901
119central nervous system projection neuron axonogenesis (GO:0021952)2.73678854
120olfactory bulb development (GO:0021772)2.70288912
121nuclear pore organization (GO:0006999)2.67950940
122protein localization to kinetochore (GO:0034501)2.67040052
123regulation of collateral sprouting (GO:0048670)2.64923313
124CENP-A containing nucleosome assembly (GO:0034080)2.64488901
125establishment of mitochondrion localization (GO:0051654)2.63059816
126behavioral response to nicotine (GO:0035095)2.62796070
127protein deneddylation (GO:0000338)2.62738559
128glial cell proliferation (GO:0014009)2.54890841
129histone exchange (GO:0043486)2.54702175
130retinal ganglion cell axon guidance (GO:0031290)2.53998401
131regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53231745
132establishment of integrated proviral latency (GO:0075713)2.52833893
133negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.52137076
134negative regulation of translation, ncRNA-mediated (GO:0040033)2.52137076
135regulation of translation, ncRNA-mediated (GO:0045974)2.52137076
136spindle checkpoint (GO:0031577)2.51621657
137negative regulation of DNA-dependent DNA replication (GO:2000104)2.49834961
138central nervous system neuron axonogenesis (GO:0021955)2.49722740
139somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48082386
140somatic hypermutation of immunoglobulin genes (GO:0016446)2.48082386
141mitotic spindle checkpoint (GO:0071174)2.44897017
142mitotic sister chromatid cohesion (GO:0007064)2.43745297
143replication fork processing (GO:0031297)2.41994672
144ephrin receptor signaling pathway (GO:0048013)2.41862778
145sister chromatid segregation (GO:0000819)2.38940761
146mitotic sister chromatid segregation (GO:0000070)2.36247149
147negative regulation of axon guidance (GO:1902668)2.34731866
148negative regulation of mitotic sister chromatid separation (GO:2000816)2.33044981
149negative regulation of sister chromatid segregation (GO:0033046)2.33044981
150negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.33044981
151negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.33044981
152negative regulation of mitotic sister chromatid segregation (GO:0033048)2.33044981
153pore complex assembly (GO:0046931)2.32499596
154glycosphingolipid biosynthetic process (GO:0006688)2.31008963
155negative regulation of chromosome segregation (GO:0051985)2.30614757
156limb bud formation (GO:0060174)2.29924253
157non-recombinational repair (GO:0000726)2.27305309
158double-strand break repair via nonhomologous end joining (GO:0006303)2.27305309
159neuromuscular synaptic transmission (GO:0007274)2.24994929
160behavioral response to ethanol (GO:0048149)2.22276802
161microtubule polymerization or depolymerization (GO:0031109)2.21840567
162neuron projection extension involved in neuron projection guidance (GO:1902284)2.20611164
163axon extension involved in axon guidance (GO:0048846)2.20611164
164L-serine metabolic process (GO:0006563)2.20584441
165negative chemotaxis (GO:0050919)2.20574451
166neurofilament cytoskeleton organization (GO:0060052)2.19041248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.86669353
2GBX2_23144817_ChIP-Seq_PC3_Human3.91865760
3E2F7_22180533_ChIP-Seq_HELA_Human3.58905005
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.29477760
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17128743
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10454400
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99156639
8REST_21632747_ChIP-Seq_MESCs_Mouse2.79932153
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64048231
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62199293
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62199293
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57280154
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.56843298
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49353959
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48817068
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46927750
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43430772
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41514126
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36197732
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29123240
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.28462973
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27496961
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24606423
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.18459117
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.17684521
26* EWS_26573619_Chip-Seq_HEK293_Human2.17359405
27* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17343487
28* TAF15_26573619_Chip-Seq_HEK293_Human2.16134803
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.15863170
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13788583
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10460555
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.07980267
33* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98332657
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97366938
35* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96354472
36DROSHA_22980978_ChIP-Seq_HELA_Human1.91627808
37AR_21572438_ChIP-Seq_LNCaP_Human1.90813262
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90653738
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87573724
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.82607403
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.82334046
42* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72495257
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.71333905
44* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70711604
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69996462
46ZNF274_21170338_ChIP-Seq_K562_Hela1.69844711
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.67361102
48* P300_19829295_ChIP-Seq_ESCs_Human1.66756032
49* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60061401
50IGF1R_20145208_ChIP-Seq_DFB_Human1.59976945
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59762456
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.53348572
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46683098
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46342333
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.46019137
56AR_25329375_ChIP-Seq_VCAP_Human1.45186033
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45027671
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44105641
59RNF2_27304074_Chip-Seq_NSC_Mouse1.43518092
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43341785
61* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40492288
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40254107
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.39654147
64ELK1_19687146_ChIP-ChIP_HELA_Human1.38696992
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38061521
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37213892
67MYC_18940864_ChIP-ChIP_HL60_Human1.36194847
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35505465
69FUS_26573619_Chip-Seq_HEK293_Human1.34878740
70* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34062340
71* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33613700
72* PIAS1_25552417_ChIP-Seq_VCAP_Human1.31925555
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31725977
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30856995
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.30687180
76* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30202142
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29772964
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.29752771
79* SOX9_26525672_Chip-Seq_HEART_Mouse1.29331686
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28796338
81STAT3_23295773_ChIP-Seq_U87_Human1.28745427
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27452990
83VDR_22108803_ChIP-Seq_LS180_Human1.26111216
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.25017831
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23392324
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22892621
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22646670
88* RING1B_27294783_Chip-Seq_ESCs_Mouse1.21154536
89AR_21909140_ChIP-Seq_LNCAP_Human1.20720580
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20341581
91MYC_18555785_ChIP-Seq_MESCs_Mouse1.16418012
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16251022
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16010060
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15316902
95JUN_21703547_ChIP-Seq_K562_Human1.15264563
96* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15231228
97AR_19668381_ChIP-Seq_PC3_Human1.14682880
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13912744
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13665459
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.12653976
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11002142
102ETS1_20019798_ChIP-Seq_JURKAT_Human1.10894454
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.10330911
104TCF4_23295773_ChIP-Seq_U87_Human1.09214375
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07902036
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07159996
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06317058
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06192979
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04942273
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04899597
111* RUNX2_22187159_ChIP-Seq_PCA_Human1.04640633
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04419702
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.04386978
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04330083
115* RING1B_27294783_Chip-Seq_NPCs_Mouse1.03989786
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02847727
117ER_23166858_ChIP-Seq_MCF-7_Human1.01968203
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01690065
119RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01535704
120* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01394045
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00973065
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00666261
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00197641
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.00073245
125AHR_22903824_ChIP-Seq_MCF-7_Human0.99109901
126E2F1_21310950_ChIP-Seq_MCF-7_Human0.99048433
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98830258
128TP63_19390658_ChIP-ChIP_HaCaT_Human0.98752081
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.98535118
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.98338480
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.98258646
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97995028
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97995028
134P53_22387025_ChIP-Seq_ESCs_Mouse0.96773121
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96563720
136WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93458312
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93147938
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93097111
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.92405169
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91447061
141BCAT_22108803_ChIP-Seq_LS180_Human0.91276999
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90875205
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89112542
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.88759123
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88642538
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87350036
147CBP_20019798_ChIP-Seq_JUKART_Human0.87350036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.62375187
2MP0003880_abnormal_central_pattern4.74527284
3MP0003635_abnormal_synaptic_transmissio3.94523771
4MP0004270_analgesia3.75729589
5MP0001968_abnormal_touch/_nociception3.52182466
6MP0009745_abnormal_behavioral_response3.33996396
7MP0002063_abnormal_learning/memory/cond3.24606314
8MP0002735_abnormal_chemical_nociception3.19235540
9MP0009046_muscle_twitch3.07723281
10MP0002064_seizures3.04340716
11MP0002736_abnormal_nociception_after2.90772065
12MP0002734_abnormal_mechanical_nocicepti2.88930280
13MP0002572_abnormal_emotion/affect_behav2.82150735
14MP0006276_abnormal_autonomic_nervous2.71807044
15MP0002822_catalepsy2.71585159
16MP0000579_abnormal_nail_morphology2.67794892
17MP0005423_abnormal_somatic_nervous2.64187545
18MP0002272_abnormal_nervous_system2.56855106
19MP0000372_irregular_coat_pigmentation2.47790753
20MP0002733_abnormal_thermal_nociception2.47087169
21MP0001440_abnormal_grooming_behavior2.34004613
22MP0001486_abnormal_startle_reflex2.31041258
23MP0001501_abnormal_sleep_pattern2.30155265
24MP0001970_abnormal_pain_threshold2.21433334
25MP0002067_abnormal_sensory_capabilities2.17079517
26MP0002184_abnormal_innervation2.13705803
27MP0000778_abnormal_nervous_system2.09776442
28MP0004858_abnormal_nervous_system1.99259757
29MP0003329_amyloid_beta_deposits1.98461965
30MP0003136_yellow_coat_color1.97027734
31MP0005386_behavior/neurological_phenoty1.95602593
32MP0004924_abnormal_behavior1.95602593
33MP0002234_abnormal_pharynx_morphology1.91757970
34MP0005171_absent_coat_pigmentation1.88798805
35MP0010094_abnormal_chromosome_stability1.84398492
36MP0008058_abnormal_DNA_repair1.78159329
37MP0004811_abnormal_neuron_physiology1.77617370
38MP0002557_abnormal_social/conspecific_i1.76620638
39MP0002938_white_spotting1.69112785
40MP0000955_abnormal_spinal_cord1.66745164
41MP0001905_abnormal_dopamine_level1.63391321
42MP0001529_abnormal_vocalization1.59472775
43MP0008932_abnormal_embryonic_tissue1.58966420
44MP0008569_lethality_at_weaning1.56101815
45* MP0002882_abnormal_neuron_morphology1.46310985
46MP0009780_abnormal_chondrocyte_physiolo1.44710483
47MP0004142_abnormal_muscle_tone1.43979034
48MP0001984_abnormal_olfaction1.43557078
49MP0002066_abnormal_motor_capabilities/c1.42124580
50MP0003111_abnormal_nucleus_morphology1.41508369
51MP0003879_abnormal_hair_cell1.39814771
52MP0005646_abnormal_pituitary_gland1.38564434
53MP0001188_hyperpigmentation1.38128145
54MP0003890_abnormal_embryonic-extraembry1.35981613
55MP0002909_abnormal_adrenal_gland1.34851559
56MP0003941_abnormal_skin_development1.33710932
57MP0005075_abnormal_melanosome_morpholog1.30511044
58MP0004957_abnormal_blastocyst_morpholog1.29390099
59MP0008057_abnormal_DNA_replication1.28876119
60MP0003937_abnormal_limbs/digits/tail_de1.28238710
61MP0003122_maternal_imprinting1.26169950
62MP0000537_abnormal_urethra_morphology1.25790693
63MP0004885_abnormal_endolymph1.25493682
64MP0003787_abnormal_imprinting1.25273823
65MP0005645_abnormal_hypothalamus_physiol1.22641695
66MP0008789_abnormal_olfactory_epithelium1.17635727
67MP0001293_anophthalmia1.17317608
68MP0005253_abnormal_eye_physiology1.15138521
69MP0003755_abnormal_palate_morphology1.14777093
70MP0005248_abnormal_Harderian_gland1.14192157
71MP0008877_abnormal_DNA_methylation1.14043126
72MP0002152_abnormal_brain_morphology1.12794577
73MP0003693_abnormal_embryo_hatching1.12541535
74MP0002095_abnormal_skin_pigmentation1.11751674
75MP0001502_abnormal_circadian_rhythm1.09001063
76MP0003077_abnormal_cell_cycle1.08000386
77MP0005408_hypopigmentation1.06861267
78MP0001324_abnormal_eye_pigmentation1.05833229
79MP0002233_abnormal_nose_morphology1.05628050
80MP0003633_abnormal_nervous_system1.05497552
81MP0008872_abnormal_physiological_respon1.04817637
82MP0003119_abnormal_digestive_system1.03763644
83MP0000647_abnormal_sebaceous_gland1.03272593
84MP0000751_myopathy1.00913700
85MP0003631_nervous_system_phenotype0.99818710
86MP0002229_neurodegeneration0.98062932
87MP0002697_abnormal_eye_size0.97290975
88MP0000015_abnormal_ear_pigmentation0.93820298
89MP0003567_abnormal_fetal_cardiomyocyte0.93789265
90MP0000569_abnormal_digit_pigmentation0.92921289
91MP0005551_abnormal_eye_electrophysiolog0.92391246
92MP0002752_abnormal_somatic_nervous0.92270068
93MP0001963_abnormal_hearing_physiology0.92254187
94MP0000631_abnormal_neuroendocrine_gland0.90853969
95MP0004145_abnormal_muscle_electrophysio0.90831664
96MP0002837_dystrophic_cardiac_calcinosis0.90825290
97MP0008007_abnormal_cellular_replicative0.89975350
98MP0002069_abnormal_eating/drinking_beha0.89503810
99MP0004742_abnormal_vestibular_system0.87533834
100MP0003385_abnormal_body_wall0.87498155
101MP0002876_abnormal_thyroid_physiology0.86486161
102MP0010386_abnormal_urinary_bladder0.85555474
103MP0000427_abnormal_hair_cycle0.85339029
104MP0000566_synostosis0.84556831
105MP0003632_abnormal_nervous_system0.84161747
106MP0000049_abnormal_middle_ear0.84021412
107MP0000604_amyloidosis0.84001134
108MP0005499_abnormal_olfactory_system0.82987139
109MP0005394_taste/olfaction_phenotype0.82987139
110MP0003123_paternal_imprinting0.82693775
111MP0000762_abnormal_tongue_morphology0.82615418
112MP0002177_abnormal_outer_ear0.82282772
113MP0003718_maternal_effect0.81124559
114MP0004085_abnormal_heartbeat0.81019435
115MP0010030_abnormal_orbit_morphology0.80960750
116MP0003634_abnormal_glial_cell0.80808670
117MP0005535_abnormal_body_temperature0.80376137
118MP0005391_vision/eye_phenotype0.79710215
119MP0002081_perinatal_lethality0.79158406
120MP0003935_abnormal_craniofacial_develop0.78943505
121MP0004233_abnormal_muscle_weight0.78769124
122MP0002160_abnormal_reproductive_system0.77334103
123MP0010234_abnormal_vibrissa_follicle0.76904721
124MP0004484_altered_response_of0.76235568
125MP0008874_decreased_physiological_sensi0.74990445
126MP0004215_abnormal_myocardial_fiber0.73712314
127MP0001986_abnormal_taste_sensitivity0.73474136
128MP0001664_abnormal_digestion0.71966247
129MP0002638_abnormal_pupillary_reflex0.70973898
130MP0003861_abnormal_nervous_system0.70894629
131MP0002751_abnormal_autonomic_nervous0.66496786
132MP0005187_abnormal_penis_morphology0.63486358
133MP0001177_atelectasis0.61818322
134MP0000026_abnormal_inner_ear0.61397268
135MP0005623_abnormal_meninges_morphology0.60988422
136MP0001299_abnormal_eye_distance/0.60005511
137MP0006072_abnormal_retinal_apoptosis0.55340854
138MP0001943_abnormal_respiration0.54795635
139MP0001348_abnormal_lacrimal_gland0.54755174
140MP0003283_abnormal_digestive_organ0.53711312
141MP0003121_genomic_imprinting0.53651343
142MP0003137_abnormal_impulse_conducting0.53001936
143MP0002090_abnormal_vision0.52620935
144MP0010770_preweaning_lethality0.52356409
145MP0002082_postnatal_lethality0.52356409
146MP0010769_abnormal_survival0.51977800
147MP0001485_abnormal_pinna_reflex0.51165986
148MP0002102_abnormal_ear_morphology0.50945334
149MP0003646_muscle_fatigue0.50106028

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.79935393
2Myokymia (HP:0002411)6.35814682
3Focal seizures (HP:0007359)5.23838697
4Visual hallucinations (HP:0002367)5.07507764
5Atonic seizures (HP:0010819)4.87250097
6Epileptic encephalopathy (HP:0200134)4.43393183
7Febrile seizures (HP:0002373)4.29688098
8Progressive cerebellar ataxia (HP:0002073)4.29571895
9Absence seizures (HP:0002121)4.15056288
10Action tremor (HP:0002345)3.79219850
11Dialeptic seizures (HP:0011146)3.71113094
12Generalized tonic-clonic seizures (HP:0002069)3.64064054
13Broad-based gait (HP:0002136)3.51491553
14Hyperventilation (HP:0002883)3.49822135
15Supranuclear gaze palsy (HP:0000605)3.34226290
16Abnormality of the labia minora (HP:0012880)3.33412364
17Limb dystonia (HP:0002451)3.25561443
18Mutism (HP:0002300)3.24025100
19Termporal pattern (HP:0011008)3.10062506
20Insidious onset (HP:0003587)3.10062506
21Ankle clonus (HP:0011448)3.09967449
22Abnormal eating behavior (HP:0100738)3.06248694
23Truncal ataxia (HP:0002078)2.99907182
24Impaired vibration sensation in the lower limbs (HP:0002166)2.99667652
25Amblyopia (HP:0000646)2.99130369
26Progressive inability to walk (HP:0002505)2.94170719
27Poor eye contact (HP:0000817)2.93917374
28Pheochromocytoma (HP:0002666)2.91367793
29Fragile nails (HP:0001808)2.91301830
30Abnormality of the corticospinal tract (HP:0002492)2.89484507
31Drooling (HP:0002307)2.85341857
32Excessive salivation (HP:0003781)2.85341857
33Amyotrophic lateral sclerosis (HP:0007354)2.83861517
34Polyphagia (HP:0002591)2.83235385
35Dysdiadochokinesis (HP:0002075)2.81356298
36Gaze-evoked nystagmus (HP:0000640)2.81328254
37Urinary bladder sphincter dysfunction (HP:0002839)2.79689495
38Fetal akinesia sequence (HP:0001989)2.77123474
39Astrocytoma (HP:0009592)2.74994870
40Abnormality of the astrocytes (HP:0100707)2.74994870
41Anxiety (HP:0000739)2.74982583
42Depression (HP:0000716)2.73264565
43Urinary urgency (HP:0000012)2.72465272
44Cerebral inclusion bodies (HP:0100314)2.67013506
45Abnormal social behavior (HP:0012433)2.66428966
46Impaired social interactions (HP:0000735)2.66428966
47Ependymoma (HP:0002888)2.63775579
48Gait imbalance (HP:0002141)2.60569426
49Neuroendocrine neoplasm (HP:0100634)2.58867019
50Dysmetria (HP:0001310)2.56208065
51Abnormality of binocular vision (HP:0011514)2.53461786
52Diplopia (HP:0000651)2.53461786
53Spastic gait (HP:0002064)2.50085673
54Abnormality of the lower motor neuron (HP:0002366)2.48372895
55Inability to walk (HP:0002540)2.44562956
56Esophageal atresia (HP:0002032)2.44333546
57Glioma (HP:0009733)2.41214316
58Epileptiform EEG discharges (HP:0011182)2.40604545
59Neurofibrillary tangles (HP:0002185)2.40256798
60Abnormal lung lobation (HP:0002101)2.37303480
61Cortical dysplasia (HP:0002539)2.37138863
62Scanning speech (HP:0002168)2.35215166
63Birth length less than 3rd percentile (HP:0003561)2.34746859
64Intestinal atresia (HP:0011100)2.34233410
65EEG with generalized epileptiform discharges (HP:0011198)2.31013761
66Bradykinesia (HP:0002067)2.30605795
67Hemiparesis (HP:0001269)2.30202345
68Torticollis (HP:0000473)2.28673617
69Failure to thrive in infancy (HP:0001531)2.28362256
70Papilledema (HP:0001085)2.27071764
71Onycholysis (HP:0001806)2.26504613
72Genetic anticipation (HP:0003743)2.24437502
73Akinesia (HP:0002304)2.24083496
74Impaired smooth pursuit (HP:0007772)2.22850041
75Abnormality of glycolysis (HP:0004366)2.19989758
76Volvulus (HP:0002580)2.19861663
77Postural instability (HP:0002172)2.18275767
78Delusions (HP:0000746)2.18248562
79Poor suck (HP:0002033)2.17160562
80Hypsarrhythmia (HP:0002521)2.16941016
81Cerebral hypomyelination (HP:0006808)2.16228785
82Labial hypoplasia (HP:0000066)2.15808951
83Focal dystonia (HP:0004373)2.13278721
84Hypoplastic female external genitalia (HP:0012815)2.11331936
85Absent speech (HP:0001344)2.11322184
86Gastrointestinal atresia (HP:0002589)2.10995016
87Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.10900875
88Ulnar claw (HP:0001178)2.10004734
89Milia (HP:0001056)2.08964666
90Specific learning disability (HP:0001328)2.07433780
91Lower limb muscle weakness (HP:0007340)2.06757161
92Hypoplasia of the brainstem (HP:0002365)2.05814023
93Aplasia/Hypoplasia of the brainstem (HP:0007362)2.05814023
94Medulloblastoma (HP:0002885)2.04939967
95Agitation (HP:0000713)2.04438315
96Hypoplastic labia majora (HP:0000059)2.02181383
97CNS hypomyelination (HP:0003429)2.01669841
98Hypoventilation (HP:0002791)1.98809163
99Congenital primary aphakia (HP:0007707)1.98050111
100Megalencephaly (HP:0001355)1.97607463
101Craniofacial dystonia (HP:0012179)1.97282344
102Generalized myoclonic seizures (HP:0002123)1.97085141
103Abnormality of ocular smooth pursuit (HP:0000617)1.96151548
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.94951741
105Morphological abnormality of the pyramidal tract (HP:0002062)1.94622336
106Impaired pain sensation (HP:0007328)1.94307838
107Abnormality of pain sensation (HP:0010832)1.94307838
108Stereotypic behavior (HP:0000733)1.93714292
109White forelock (HP:0002211)1.93526737
110Abnormal hair whorl (HP:0010721)1.93043548
111Colon cancer (HP:0003003)1.92916342
112Inappropriate behavior (HP:0000719)1.92719218
113Plantar hyperkeratosis (HP:0007556)1.92529362
114Patchy hypopigmentation of hair (HP:0011365)1.91525411
115Neoplasm of the peripheral nervous system (HP:0100007)1.90585743
116Intention tremor (HP:0002080)1.88961962
117Rhabdomyosarcoma (HP:0002859)1.88570742
118Abnormality of chromosome stability (HP:0003220)1.88414924
119Cutaneous finger syndactyly (HP:0010554)1.88035297
120Genital tract atresia (HP:0001827)1.87987566
121Gait ataxia (HP:0002066)1.86634121
122Incomplete penetrance (HP:0003829)1.86121979
123Freckling (HP:0001480)1.85679428
124Esotropia (HP:0000565)1.85035795
125Abnormality of salivation (HP:0100755)1.84783486
126Meckel diverticulum (HP:0002245)1.83615818
127Nephrogenic diabetes insipidus (HP:0009806)1.82818327
128Impaired vibratory sensation (HP:0002495)1.81957211
129Dysmetric saccades (HP:0000641)1.81218462
130Degeneration of the lateral corticospinal tracts (HP:0002314)1.80967595
131Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80967595
132Facial cleft (HP:0002006)1.80887455
133Increased serum pyruvate (HP:0003542)1.80559769
134Status epilepticus (HP:0002133)1.80342562
135Aqueductal stenosis (HP:0002410)1.79990525
136Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79725208
137Blue irides (HP:0000635)1.79171085
138Abnormality of the labia majora (HP:0012881)1.77178464
139Abnormality of the ileum (HP:0001549)1.76143782
140Small intestinal stenosis (HP:0012848)1.73191288
141Duodenal stenosis (HP:0100867)1.73191288
142Agnosia (HP:0010524)1.71653318
143Vaginal atresia (HP:0000148)1.70511859
144Bifid tongue (HP:0010297)1.68623239
145Chromsome breakage (HP:0040012)1.67719277
146Hepatoblastoma (HP:0002884)1.67666990
147Retinal dysplasia (HP:0007973)1.66791501
148Hypoplasia of the fovea (HP:0007750)1.65591058
149Aplasia/Hypoplasia of the fovea (HP:0008060)1.65591058
150Atrophic scars (HP:0001075)1.64724009
151Oligodactyly (hands) (HP:0001180)1.64049427
152Abnormality of the preputium (HP:0100587)1.64010061
153Exotropia (HP:0000577)1.63324340
154Atrophy/Degeneration involving motor neurons (HP:0007373)1.63261129
155Abnormality of the labia (HP:0000058)1.62826647
156Sleep apnea (HP:0010535)1.62318819
157Abnormality of the duodenum (HP:0002246)1.62242659
158Narrow forehead (HP:0000341)1.61563714
159Medial flaring of the eyebrow (HP:0010747)1.61494627
160Astigmatism (HP:0000483)1.61088964
161Cutaneous syndactyly (HP:0012725)1.59568048
162Absent eyebrow (HP:0002223)1.59198592
163Aplasia/Hypoplasia of the macula (HP:0008059)1.58949754
164Neoplasm of the adrenal cortex (HP:0100641)1.58447227
165Small hand (HP:0200055)1.57826711
166Patellar aplasia (HP:0006443)1.57105995
167Hypopigmentation of the fundus (HP:0007894)1.56553679
168Abnormality of the fovea (HP:0000493)1.55145901
169Increased nuchal translucency (HP:0010880)1.54030709
170Lissencephaly (HP:0001339)1.53798047
171Abnormality of midbrain morphology (HP:0002418)1.53614478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.18349409
2NTRK34.00345728
3MAP3K93.83653876
4MAP3K43.59399414
5TRIM283.42975102
6MAP2K73.22968189
7EPHA43.12132701
8MINK13.04794585
9CASK2.75563026
10MAP3K122.59291413
11BUB12.48565251
12SRPK12.40260688
13MAP2K42.21737939
14NTRK22.09131966
15KSR22.04037004
16PNCK1.96254511
17TSSK61.94872354
18NTRK11.94617891
19WEE11.92657429
20PAK61.91223697
21PLK31.88755133
22TTK1.85295027
23PLK21.79443220
24FRK1.79255750
25MKNK21.79120522
26DAPK21.78902959
27CDC71.75813196
28MAPK131.74343896
29GRK51.70880007
30MKNK11.67503405
31LATS21.66177568
32KSR11.65154983
33PLK41.55579831
34DAPK11.41085240
35CDK51.40394400
36PHKG11.37822286
37PHKG21.37822286
38ZAK1.36897394
39CAMKK11.30630085
40ARAF1.24499234
41RIPK41.24303830
42MAP4K21.22590365
43CDK191.22202417
44PRKCG1.19743031
45FGFR21.17945842
46CSNK1A1L1.16418661
47PLK11.15449875
48TNIK1.10346140
49CSNK1G21.09870978
50EIF2AK31.09130151
51SIK21.09011768
52CAMK2A1.06732365
53CAMKK21.02483385
54WNK31.01025383
55STK380.97248749
56OXSR10.96897770
57EPHB20.96076912
58EIF2AK10.93364055
59CDK30.93338143
60SIK30.92007432
61CDK140.91035192
62CDK180.90033866
63RET0.88449089
64PRPF4B0.88080318
65SGK4940.88075633
66SGK2230.88075633
67BMPR1B0.86861248
68CDK150.86581105
69DYRK30.85633405
70UHMK10.84933887
71MAP3K20.84660300
72PTK2B0.83136558
73NME10.82897825
74LMTK20.81911890
75DYRK20.79084514
76ATR0.78531260
77PBK0.78283369
78PAK30.77583775
79VRK10.76603506
80DYRK1A0.76456519
81BRD40.76130884
82CDK11A0.73830644
83SGK20.73653479
84MAP3K60.73627828
85CSNK1G30.70292036
86FES0.69220168
87MAP3K130.69050194
88INSRR0.68505822
89NEK10.67464345
90ADRBK20.67218325
91CAMK2B0.67028972
92PRKD30.65984310
93STK110.65979878
94BMPR20.65865495
95RPS6KA40.64783520
96STK38L0.64435956
97RAF10.63000068
98CHEK20.62905500
99GRK70.61653448
100ATM0.60818928
101PRKCE0.60751076
102BRSK10.60074928
103PINK10.59711065
104PDK40.59008407
105PDK30.59008407
106TYRO30.58059226
107CAMK10.57632464
108TAOK10.57528250
109FGR0.56222251
110ADRBK10.54299045
111AKT30.53364170
112BRSK20.51925498
113MUSK0.51832649
114CSNK1E0.51014432
115MAP2K10.50764818
116SGK10.50429183
117TGFBR10.50061558
118FER0.49609678
119PRKCZ0.49339070
120ERBB30.48841469
121STK160.47388652
122MARK20.47032051
123CCNB10.46540329
124YES10.46254340
125PRKCH0.46245035
126LIMK10.44586430
127ALK0.43641044
128PKN10.43211772
129SGK30.42624026
130PRKDC0.42296764
131TNK20.42047337
132CDK10.41120811
133BRAF0.40871571
134MET0.40190651
135EIF2AK20.39801919
136AURKB0.38869067
137SCYL20.38842087
138CAMK2G0.38731471
139CSNK1D0.38161890
140RPS6KA30.38130834
141CHEK10.38039920
142CAMK2D0.37274158
143CSNK1G10.37096660
144BCR0.37018365
145WNK10.36684426
146PDK10.36370379
147MAPK100.36246299
148RPS6KA20.36039271
149CDK20.34592648
150AURKA0.33880662
151LATS10.32534789
152CSNK1A10.30454182

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.09927814
2Synaptic vesicle cycle_Homo sapiens_hsa047213.71612200
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79291955
4Non-homologous end-joining_Homo sapiens_hsa034502.78066798
5GABAergic synapse_Homo sapiens_hsa047272.64841461
6Olfactory transduction_Homo sapiens_hsa047402.61715985
7Long-term potentiation_Homo sapiens_hsa047202.54541346
8Circadian entrainment_Homo sapiens_hsa047132.54161981
9Morphine addiction_Homo sapiens_hsa050322.43651361
10Glutamatergic synapse_Homo sapiens_hsa047242.43505022
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38212388
12Amphetamine addiction_Homo sapiens_hsa050312.36839968
13Mismatch repair_Homo sapiens_hsa034302.33800064
14Dopaminergic synapse_Homo sapiens_hsa047282.26357709
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23426422
16Collecting duct acid secretion_Homo sapiens_hsa049662.20295851
17Taste transduction_Homo sapiens_hsa047422.07243339
18Salivary secretion_Homo sapiens_hsa049702.02766950
19Serotonergic synapse_Homo sapiens_hsa047261.96290622
20Steroid biosynthesis_Homo sapiens_hsa001001.88432448
21DNA replication_Homo sapiens_hsa030301.83897516
22Cholinergic synapse_Homo sapiens_hsa047251.83756299
23Fanconi anemia pathway_Homo sapiens_hsa034601.81460762
24Insulin secretion_Homo sapiens_hsa049111.80090047
25Protein export_Homo sapiens_hsa030601.79442135
26Long-term depression_Homo sapiens_hsa047301.75883688
27Gastric acid secretion_Homo sapiens_hsa049711.74555446
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66795317
29Cocaine addiction_Homo sapiens_hsa050301.65119023
30Renin secretion_Homo sapiens_hsa049241.64291831
31Cell cycle_Homo sapiens_hsa041101.64073553
32Homologous recombination_Homo sapiens_hsa034401.62201197
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59739988
34RNA polymerase_Homo sapiens_hsa030201.56737420
35Calcium signaling pathway_Homo sapiens_hsa040201.53916499
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53800601
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53719896
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53035845
39RNA transport_Homo sapiens_hsa030131.52445392
40Proteasome_Homo sapiens_hsa030501.50262452
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49254259
42Oxytocin signaling pathway_Homo sapiens_hsa049211.48033212
43Basal transcription factors_Homo sapiens_hsa030221.43026034
44Vitamin B6 metabolism_Homo sapiens_hsa007501.40509942
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38979209
46Gap junction_Homo sapiens_hsa045401.37795396
47GnRH signaling pathway_Homo sapiens_hsa049121.35846933
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30911343
49Vibrio cholerae infection_Homo sapiens_hsa051101.30052984
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26359584
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25819011
52Cardiac muscle contraction_Homo sapiens_hsa042601.25597276
53RNA degradation_Homo sapiens_hsa030181.24763581
54Spliceosome_Homo sapiens_hsa030401.24335599
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21440442
56Axon guidance_Homo sapiens_hsa043601.20602394
57Nucleotide excision repair_Homo sapiens_hsa034201.19877531
58Oxidative phosphorylation_Homo sapiens_hsa001901.19357270
59Base excision repair_Homo sapiens_hsa034101.17229208
60Propanoate metabolism_Homo sapiens_hsa006401.16683345
61One carbon pool by folate_Homo sapiens_hsa006701.12908143
62Fatty acid elongation_Homo sapiens_hsa000621.11532636
63cAMP signaling pathway_Homo sapiens_hsa040241.10105558
64Estrogen signaling pathway_Homo sapiens_hsa049151.07836874
65Oocyte meiosis_Homo sapiens_hsa041141.04632535
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.04459808
67Phototransduction_Homo sapiens_hsa047441.03962802
68ErbB signaling pathway_Homo sapiens_hsa040121.02799971
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02227352
70Alzheimers disease_Homo sapiens_hsa050100.99848037
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99133168
72mRNA surveillance pathway_Homo sapiens_hsa030150.98690194
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98565834
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98241466
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97145124
76Parkinsons disease_Homo sapiens_hsa050120.96993932
77Glioma_Homo sapiens_hsa052140.94973886
78Hippo signaling pathway_Homo sapiens_hsa043900.94350916
79Melanogenesis_Homo sapiens_hsa049160.93259923
80Type II diabetes mellitus_Homo sapiens_hsa049300.93077628
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92101784
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91907521
83Pyruvate metabolism_Homo sapiens_hsa006200.90888617
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86121937
85Hedgehog signaling pathway_Homo sapiens_hsa043400.86045916
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83991144
87Biosynthesis of amino acids_Homo sapiens_hsa012300.81582274
88Purine metabolism_Homo sapiens_hsa002300.79504082
89p53 signaling pathway_Homo sapiens_hsa041150.77709725
90Pyrimidine metabolism_Homo sapiens_hsa002400.75619645
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.74948042
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72640757
93Choline metabolism in cancer_Homo sapiens_hsa052310.71800224
94Dorso-ventral axis formation_Homo sapiens_hsa043200.71394561
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69902697
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68656235
97Pancreatic secretion_Homo sapiens_hsa049720.68624960
98Basal cell carcinoma_Homo sapiens_hsa052170.67928523
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67561120
100Huntingtons disease_Homo sapiens_hsa050160.64431144
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.64096403
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63828796
103Thyroid hormone synthesis_Homo sapiens_hsa049180.63589959
104MAPK signaling pathway_Homo sapiens_hsa040100.63306974
105Selenocompound metabolism_Homo sapiens_hsa004500.61968552
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61427483
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57829288
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.56457912
109Ras signaling pathway_Homo sapiens_hsa040140.56028858
110Alcoholism_Homo sapiens_hsa050340.55150527
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54835101
112Carbon metabolism_Homo sapiens_hsa012000.53809562
113Glucagon signaling pathway_Homo sapiens_hsa049220.51411954
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50995349
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49886157
116Dilated cardiomyopathy_Homo sapiens_hsa054140.49781098
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47327047
118Melanoma_Homo sapiens_hsa052180.46430207
119Rap1 signaling pathway_Homo sapiens_hsa040150.46304500
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46234288
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46135035
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.45325521
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44832703
124VEGF signaling pathway_Homo sapiens_hsa043700.43452607
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43009261
126Tight junction_Homo sapiens_hsa045300.42845876
127Endometrial cancer_Homo sapiens_hsa052130.41889034
128mTOR signaling pathway_Homo sapiens_hsa041500.41485541
129Colorectal cancer_Homo sapiens_hsa052100.41482980
130Renal cell carcinoma_Homo sapiens_hsa052110.41047941
131TGF-beta signaling pathway_Homo sapiens_hsa043500.40985507
132Rheumatoid arthritis_Homo sapiens_hsa053230.40044842
133Wnt signaling pathway_Homo sapiens_hsa043100.39121887
134Metabolic pathways_Homo sapiens_hsa011000.38632660
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38605435
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38140125
137Bile secretion_Homo sapiens_hsa049760.38082018
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37910041
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37673007
140Insulin signaling pathway_Homo sapiens_hsa049100.37595799
141Fatty acid metabolism_Homo sapiens_hsa012120.37331507
142Inositol phosphate metabolism_Homo sapiens_hsa005620.36700101
143Prion diseases_Homo sapiens_hsa050200.36171295
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35711035
145Endocytosis_Homo sapiens_hsa041440.32712628
146Circadian rhythm_Homo sapiens_hsa047100.32578472
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32543334
148Butanoate metabolism_Homo sapiens_hsa006500.30672516
149Ovarian steroidogenesis_Homo sapiens_hsa049130.30259300
150Phagosome_Homo sapiens_hsa041450.29198943
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28555101
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.28164525
153Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27785391

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